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18 results on '"Na, Seong-Kyun"'

3. Prognosis Following Sustained Virologic Response in Korean Chronic Hepatitis C Patients Treated with Sofosbuvir-Based Treatment: Data from a Multicenter Prospective Observational Study up to 7 Years.

Author

Park, Yewan, Na, Seong-Kyun, Yoon, Jae-Hyun, Kim, Sung-Eun, Park, Ji-Won, Kim, Gi-Ae, Lee, Hyo-Young, Lee, Young-Sun, and Kim, Jeong-Han

Subjects
CHRONIC hepatitis C, OLDER patients, LONGITUDINAL method, SCIENTIFIC observation, PROGNOSIS
Abstract

Background and Objectives: Chronic hepatitis C (CHC) can be cured with direct-acting antiviral (DAA) therapy. In Korea, sofosbuvir (SOF) and ledipasvir (LDV)/SOF were launched in 2016. Patients who achieve a sustained virologic response (SVR) following DAA treatment are predicted to have a favorable prognosis. Nevertheless, little is known regarding the prognosis of Korean CHC patients who receive SOF-based treatment and achieve SVR. Therefore, the purpose of this study was to look into the long-term outcomes for these patients. Materials and Methods: This was a prospective, multicenter observational study. CHC patients were enrolled who, following SOF or LDV/SOF treatment, had achieved SVR. The last day for follow-up was December 2023. The primary endpoint was HCC occurrence, which was checked at least once per year. Results: A total of 516 patients were included in this analysis, with a median follow-up duration of 39.0 months. Among them, 231 were male patients (44.8%), with a median age of 62.0 years. Genotypes were 1 (90, 17.4%), 2 (423, 82.0%), and 3 (3, 0.6%). The combination of SOF plus ribavirin was the most common treatment (394, 76.4%). In total, 160 patients were cirrhotic (31.0%), and the mean Child–Pugh score was 5.1. Within a maximum of 7 years, 21 patients (4.1%) developed HCC. Patients with HCC were older (69 vs. 61 years, p = 0.013) and had a higher cirrhosis incidence (81.0 vs. 28.9%, p < 0.001), higher AFP (6.0 vs. 3.3, p = 0.003) and higher APRI (0.8 vs. 0.5, p = 0.005). Age over 65 (p = 0.016) and cirrhosis (p = 0.005) were found to be significant risk factors for HCC by Cox regression analysis. Conclusions: Patients who achieved SVR with SOF-based treatment had a relatively favorable prognosis. However, the risk of HCC was not eliminated, especially in older and cirrhotic patients. Therefore, routine follow-up, surveillance, and early treatment are required. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Outcome of Intermittent Thoracentesis versus Pigtail Catheter Drainage for Hepatic Hydrothorax

Author

Han, Seul-Ki, primary, Kang, Seong-Hee, additional, Kim, Moon-Young, additional, Na, Seong-Kyun, additional, Kim, Taehyung, additional, Lee, Minjong, additional, Jun, Baek-Gyu, additional, Kim, Tae-Suk, additional, Choi, Dae-Hee, additional, Suk, Ki-Tae, additional, Kim, Young-Don, additional, Cheon, Gab-Jin, additional, Yim, Hyung-Joon, additional, Kim, Dong-Joon, additional, and Baik, Soon-Koo, additional

Published
2022
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10. Prognostic assessment using a new substaging system for Barcelona clinic liver cancer stage C hepatocellular carcinoma: A nationwide study

Author

Lee, Dong‐won, primary, Yim, Hyung Joon, additional, Seo, Yeon Seok, additional, Na, Seong Kyun, additional, Kim, Seung Young, additional, Suh, Sang Jun, additional, Hyun, Jong Jin, additional, Jung, Sung Woo, additional, Jung, Young Kul, additional, Koo, Ja Seol, additional, Kim, Ji Hoon, additional, Yeon, Jong Eun, additional, Lee, Sang Woo, additional, Byun, Kwan Soo, additional, and Um, Soon Ho, additional

Published
2019
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14. Mo1488 Subclassification of Barcelona Clinic Liver Cancer Stage C Hepatocellular Carcinoma by Major Vessel Invasion and Distant Metastasis

Author

Na, Seong Kyun, primary, Lee, Dongwon, additional, Yim, Hyung Joon, additional, Kim, Seung Young, additional, Suh, Sang Jun, additional, Hyun, Jong Jin, additional, Jung, Sung Woo, additional, Jung, Young Kul, additional, Koo, Ja Seol, additional, Kim, Ji Hoon, additional, Seo, Yeon Seok, additional, Yeon, Jong Eun, additional, Lee, Sang Woo, additional, Byun, Kwan Soo, additional, and Um, Soon Ho, additional

Published
2016
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18. A Case of Bilateral ACTH-independent Adrenal Adenomas with Cushing's Syndrome Treated by Ipsilateral Total and Contralateral Partial Laparoscopic Adrenalectomy

Author

Park, Seung Ah, primary, Jung, Dong min, additional, Kim, Soon young, additional, Choi, Nan Young, additional, Kim, Tae-jun, additional, Kim, Yong kyun, additional, Na, Seong kyun, additional, Kim, Chul Sik, additional, Lee, Seong Jin, additional, Ihm, Sung-Hee, additional, and Kang, Jun Goo, additional

Published
2013
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