260 results on '"Naccache, Jean-Marc"'
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2. French recommendations for the diagnosis and management of lymphangioleiomyomatosis
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Cottin, Vincent, Blanchard, Elodie, Kerjouan, Mallorie, Lazor, Romain, Reynaud-Gaubert, Martine, Taille, Camille, Uzunhan, Yurdagül, Wemeau, Lidwine, Andrejak, Claire, Baud, Dany, Bonniaud, Philippe, Brillet, Pierre-Yves, Calender, Alain, Chalabreysse, Lara, Court-Fortune, Isabelle, Desbaillets, Nicolas Pierre, Ferretti, Gilbert, Guillemot, Anne, Hardelin, Laurane, Kambouchner, Marianne, Leclerc, Violette, Lederlin, Mathieu, Malinge, Marie-Claire, Mancel, Alain, Marchand-Adam, Sylvain, Maury, Jean-Michel, Naccache, Jean-Marc, Nasser, Mouhamad, Nunes, Hilario, Pagnoux, Gaële, Prévot, Grégoire, Rousset-Jablonski, Christine, Rouviere, Olivier, Si-Mohamed, Salim, Touraine, Renaud, Traclet, Julie, Turquier, Ségolène, Vagnarelli, Stéphane, and Ahmad, Kaïs
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- 2023
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3. French practical guidelines for the diagnosis and management of idiopathic pulmonary fibrosis – 2021 update. Full-length version
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Cottin, Vincent, Bonniaud, Philippe, Cadranel, Jacques, Crestani, Bruno, Jouneau, Stéphane, Marchand-Adam, Sylvain, Nunes, Hilario, Wémeau-Stervinou, Lidwine, Bergot, Emmanuel, Blanchard, Elodie, Borie, Raphaël, Bourdin, Arnaud, Chenivesse, Cécile, Clément, Annick, Gomez, Emmanuel, Gondouin, Anne, Hirschi, Sandrine, Lebargy, François, Marquette, Charles-Hugo, Montani, David, Prévot, Grégoire, Quetant, Sébastien, Reynaud-Gaubert, Martine, Salaun, Mathieu, Sanchez, Olivier, Trumbic, Bruno, Berkani, Karim, Brillet, Pierre-Yves, Campana, Marion, Chalabreysse, Lara, Chatté, Gérard, Debieuvre, Didier, Ferretti, Gilbert, Fourrier, Jean-Michel, Just, Nicolas, Kambouchner, Marianne, Legrand, Bertrand, Le Guillou, Frédéric, Lhuillier, Jean-Pierre, Mehdaoui, Anas, Naccache, Jean-Marc, Paganon, Catherine, Rémy-Jardin, Martine, Si-Mohamed, Salim, and Terrioux, Philippe
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- 2023
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4. Diagnosis Yield and Safety of Surgical Biopsy in Interstitial Lung Diseases: A Prospective Study
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Radu, Dana, Freynet, Olivia, Kambouchner, Marianne, Boubaya, Marouane, Nunes, Hilario, Uzunhan, Yurdagül, Brillet, Pierre-Yves, Guiraudet, Patrice, Noorah, Mohammad Zaahid, Israël-Biet, Dominique, Le Pimpec-Barthes, Françoise, Juvin, Karine, Charpentier, Anne, Gibault, Laure, Assouad, Jalal, Naccache, Jean-Marc, Antoine, Martine, Tavolaro, Sebastian, Alifano, Marco, Honoré, Isabelle, L’Huillier, Jean Pierre, Debrosse, Denis, Dupin, Clairelyne, Pradère, Pauline, Debray, Marie-Pierre, Cazes, Aurélie, Mordant, Pierre, Castier, Yves, Beloucif, Sadek, Crestani, Bruno, Lévy, Vincent, Martinod, Emmanuel, and Valeyre, Dominique
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- 2022
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5. Inhaled ciclesonide for outpatient treatment of COVID-19 in adults at risk of adverse outcomes: a randomised controlled trial (COVERAGE)
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Duvignaud, Alexandre, Lhomme, Edouard, Onaisi, Racha, Sitta, Rémi, Gelley, Ambre, Chastang, Julie, Piroth, Lionel, Binquet, Christine, Dupouy, Julie, Makinson, Alain, Lefèvre, Benjamin, Naccache, Jean-Marc, Roussillon, Caroline, Landman, Roland, Wallet, Cédrick, Karcher, Sophie, Journot, Valérie, Nguyen, Duc, Pistone, Thierry, Bouchet, Stéphane, Lafon, Marie-Edith, Molimard, Mathieu, Thiébaut, Rodolphe, de Lamballerie, Xavier, Joseph, Jean-Philippe, Richert, Laura, Saint-Lary, Olivier, Djabarouti, Sarah, Wittkop, Linda, Anglaret, Xavier, and Malvy, Denis
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- 2022
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6. Cyclophosphamide added to glucocorticoids in acute exacerbation of idiopathic pulmonary fibrosis (EXAFIP): a randomised, double-blind, placebo-controlled, phase 3 trial
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Naccache, Jean-Marc, Jouneau, Stéphane, Didier, Morgane, Borie, Raphaël, Cachanado, Marine, Bourdin, Arnaud, Reynaud-Gaubert, Martine, Bonniaud, Philippe, Israël-Biet, Dominique, Prévot, Grégoire, Hirschi, Sandrine, Lebargy, François, Marchand-Adam, Sylvain, Bautin, Nathalie, Traclet, Julie, Gomez, Emmanuel, Leroy, Sylvie, Gagnadoux, Frédéric, Rivière, Frédéric, Bergot, Emmanuel, Gondouin, Anne, Blanchard, Elodie, Parrot, Antoine, Blanc, François-Xavier, Chabrol, Alexandre, Dominique, Stéphane, Gibelin, Aude, Tazi, Abdellatif, Berard, Laurence, Brillet, Pierre Yves, Debray, Marie-Pierre, Rousseau, Alexandra, Kerjouan, Mallorie, Freynet, Olivia, Dombret, Marie-Christine, Gamez, Anne-Sophie, Nieves, Ana, Beltramo, Guillaume, Pastré, Jean, Le Borgne-Krams, Aurélie, Dégot, Tristan, Launois, Claire, Plantier, Laurent, Wémeau-Stervinou, Lidwine, Cadranel, Jacques, Chenivesse, Cécile, Valeyre, Dominique, Crestani, Bruno, Cottin, Vincent, Simon, Tabassome, and Nunes, Hilario
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- 2022
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7. Dysregulation of neutrophil oxidant production and interleukin-1–related cytokines in granulomatosis with polyangiitis.
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Amsler, Jennifer, Everts-Graber, Judith, Martin, Katherine R, Roccabianca, Arnaud, Lopes, Chloé, Tourneur, Léa, Mocek, Julie, Karras, Alexandre, Naccache, Jean-Marc, Bonnotte, Bernard, Samson, Maxime, Hanslik, Thomas, Puéchal, Xavier, Terrier, Benjamin, Guillevin, Loïc, Néel, Antoine, Mouthon, Luc, and Witko-Sarsat, Véronique
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PROTEIN metabolism ,RESEARCH funding ,NEUTROPHILS ,DISEASE remission ,GRANULOMATOSIS with polyangiitis ,REACTIVE oxygen species ,ANTIGENS ,LONGITUDINAL method ,CYTOKINES ,INFLAMMATION ,INTERLEUKINS ,GLUCOCORTICOIDS - Abstract
Objectives Neutrophils play a key role in ANCA-associated vasculitis, both as targets of autoimmunity and as facilitators of vascular damage. In granulomatosis with polyangiitis (GPA), the data regarding the production of reactive oxygen species (ROS) in neutrophils are unclear. Further, recent data suggests that ROS production could have an anti-inflammatory effect through the regulation of inflammasomes and IL-1–related cytokines. We aimed to analyse ROS production in neutrophils from patients with GPA and investigate its association with IL-1–related cytokines and the autoantigen PR3. Methods Seventy-two GPA patients with disease flare were included in the NEUTROVASC prospective cohort study. ROS production in whole blood of patients with active GPA was evaluated and compared with that in the same patients in remission or healthy controls. Associations between ROS production, PR3 membrane expression on neutrophils, serum levels of IL-1–related cytokines as well as inflammasome-related proteins were analysed. Results We observed a robust defect in ROS production by neutrophils from patients with active GPA compared with healthy controls, independent of glucocorticoid treatment. Serum levels of IL-1–related cytokines were significantly increased in GPA patients, particularly in patients with kidney involvement, and levels of these cytokines returned to normal after patients achieved remission. Further, inflammasome-related proteins were significantly dysregulated in the cytosol of neutrophils as well as the serum from GPA patients. Conclusion Our data suggests that ROS production and regulation of inflammasomes in neutrophils from patients with GPA are disturbed and may be a potential therapeutic target. Trial registration ClinicalTrials.gov, https://www.clinicaltrials.gov , NCT01862068. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Anakinra for severe forms of COVID-19: a cohort study
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Huet, Thomas, Beaussier, Hélène, Voisin, Olivier, Jouveshomme, Stéphane, Dauriat, Gaëlle, Lazareth, Isabelle, Sacco, Emmanuelle, Naccache, Jean-Marc, Bézie, Yvonnick, Laplanche, Sophie, Le Berre, Alice, Le Pavec, Jérôme, Salmeron, Sergio, Emmerich, Joseph, Mourad, Jean-Jacques, Chatellier, Gilles, and Hayem, Gilles
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- 2020
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9. Usual interstitial pneumonia in ANCA-associated vasculitis: A poor prognostic factor
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Maillet, Thibault, Goletto, Tiphaine, Beltramo, Guillaume, Dupuy, Henry, Jouneau, Stéphane, Borie, Raphael, Crestani, Bruno, Cottin, Vincent, Blockmans, Daniel, Lazaro, Estibaliz, Naccache, Jean-Marc, Pugnet, Grégory, Nunes, Hilario, de Menthon, Mathilde, Devilliers, Hervé, Bonniaud, Philippe, Puéchal, Xavier, Mouthon, Luc, Bonnotte, Bernard, Guillevin, Loïc, Terrier, Benjamin, and Samson, Maxime
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- 2020
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10. Proteomic analysis of neutrophils in ANCA-associated vasculitis reveals a dysregulation in proteinase 3-associated proteins such as annexin-A1 involved in apoptotic cell clearance
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Everts-Graber, Judith, Martin, Katherine R., Thieblemont, Nathalie, Mocek, Julie, Roccabianca, Arnaud, Chafey, Philippe, Le Gall, Morgane, Tacnet-Delorme, Pascale, Reutelingsperger, Chris P., Naccache, Jean-Marc, Bonnotte, Bernard, Karras, Alexandre, Puéchal, Xavier, Guillevin, Loïc, Terrier, Benjamin, Frachet, Philippe, Perretti, Mauro, Mouthon, Luc, and Witko-Sarsat, Véronique
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- 2019
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11. Dysregulation of neutrophil oxidant production and interleukin-1-related cytokines in granulomatosis with polyangiitis
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Amsler, Jennifer, primary, Everts-Graber, Judith, additional, Martin, Katherine R, additional, Roccabianca, Arnaud, additional, Lopes, Chloé, additional, Tourneur, Léa, additional, Mocek, Julie, additional, Karras, Alexandre, additional, Naccache, Jean-Marc, additional, Bonnotte, Bernard, additional, Samson, Maxime, additional, Hanslik, Thomas, additional, Puéchal, Xavier, additional, Terrier, Benjamin, additional, Guillevin, Loïc, additional, Néel, Antoine, additional, Mouthon, Luc, additional, and Witko-Sarsat, Véronique, additional
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- 2023
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12. Liver disease in germline mutations of telomere-related genes: Prevalence, clinical, radiological, pathological features, outcome, and risk factors
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Sidali, Sabrina, primary, Borie, Raphaël, additional, de Fontbrune, Flore Sicre, additional, El Husseini, Kinan, additional, Rautou, Pierre-Emmanuel, additional, Lainey, Elodie, additional, Goria, Odile, additional, Crestani, Bruno, additional, Cadrane, Jacques, additional, Cottin, Vincent, additional, Bune, Vincent, additional, Dumortier, Jérôme, additional, Jacquemin, Emmanuel, additional, Reboux, Noémi, additional, Hirschi, Sandrine, additional, Bourdin, Arnaud, additional, Meszaros, Magdalena, additional, Dharancy, Sebastien, additional, Hilaire, Sophie, additional, Mallet, Vincent, additional, Reynaud-Gaubert, Martine, additional, Terriou, Louis, additional, Gottrand, Frédéric, additional, Abou Chahla, Wadih, additional, Khan, Jean-Emmanuel, additional, Carrier, Paul, additional, Saliba, Faouzi, additional, Rubbia-Brandt, Laura, additional, Aubert, John-David, additional, Elkrief, Laure, additional, de Lédinghen, Victor, additional, Abergel, Armand, additional, Olivier, Tournilhac, additional, Houssel, Pauline, additional, Jouneau, Stephane, additional, Wemeau, Lidwine, additional, Bergeron, Anne, additional, Leblanc, Thierry, additional, Ollivier-Hourmand, Isabelle, additional, Nguyen Khac, Eric, additional, Morisse-Pradier, Hélène, additional, Ba, Ibrahima, additional, Boileau, Catherine, additional, Roudot-Thoraval, Françoise, additional, Vilgrain, Valérie, additional, Bureau, Christophe, additional, Nunes, Hilario, additional, Naccache, Jean-Marc, additional, Durand, François, additional, Francoz, Claire, additional, Roulot, Dominique, additional, Valla, Dominique, additional, Paradis, Valérie, additional, Kannengiesser, Caroline, additional, and Plessier, Aurélie, additional
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- 2023
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13. Hémorragies intra-alvéolaires auto-immune en rhumatologie
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Canellas, Anthony, Naccache, Jean-Marc, Parrot, Antoine, and Cadranel, Jacques
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- 2018
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14. Metastatic gestational choriocarcinoma revealed by reduced fetal movements
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Pfannstiel, Laurena, primary, Daoun, Cécile, additional, Naccache, Jean-Marc, additional, Bintein, Flore, additional, Adam, Julien, additional, and Azria, Elie, additional
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- 2023
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15. Rituximab and mycophenolate mofetil combination in patients with interstitial lung disease (EVER-ILD): a double-blind, randomised, placebo-controlled trial
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Mankikian, Julie, primary, Caille, Agnès, additional, Reynaud-Gaubert, Martine, additional, Agier, Marie-Sara, additional, Bermudez, Julien, additional, Bonniaud, Philippe, additional, Borie, Raphael, additional, Brillet, Pierre-Yves, additional, Cadranel, Jacques, additional, Court-Fortune, Isabelle, additional, Crestani, Bruno, additional, Debray, Marie-Pierre, additional, Gomez, Emmanuel, additional, Gondouin, Anne, additional, Hirschi-Santelmo, Sandrine, additional, Israel-Biet, Dominique, additional, Jouneau, Stéphane, additional, Juvin, Karine, additional, Leger, Julie, additional, Kerjouan, Mallorie, additional, Marquette, Charles-Hugo, additional, Naccache, Jean-Marc, additional, Nunes, Hilario, additional, Plantier, Laurent, additional, Prevot, Grégoire, additional, Quetant, Sébastien, additional, Traclet, Julie, additional, Valentin, Victor, additional, Uzunhan, Yurdagul, additional, Wémeau-Stervinou, Lidwine, additional, Bejan-Angoulvant, Theodora, additional, Cottin, Vincent, additional, and Marchand-Adam, Sylvain, additional
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- 2023
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16. Differential diagnosis of pulmonary sarcoidosis: a review
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Valeyre, Dominique, primary, Brauner, Michel, additional, Bernaudin, Jean-François, additional, Carbonnelle, Etienne, additional, Duchemann, Boris, additional, Rotenberg, Cécile, additional, Berger, Ingrid, additional, Martin, Antoine, additional, Nunes, Hilario, additional, Naccache, Jean-Marc, additional, and Jeny, Florence, additional
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- 2023
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17. Study protocol: exploring the efficacy of cyclophosphamide added to corticosteroids for treating acute exacerbation of idiopathic pulmonary fibrosis; a randomized double-blind, placebo-controlled, multi-center phase III trial (EXAFIP)
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Naccache, Jean-Marc, Montil, Melissa, Cadranel, Jacques, Cachanado, Marine, Cottin, Vincent, Crestani, Bruno, Valeyre, Dominique, Wallaert, Benoit, Simon, Tabassome, and Nunes, Hilario
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- 2019
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18. Severe hematologic complications after lung transplantation in patients with telomerase complex mutations
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Borie, Raphael, Kannengiesser, Caroline, Hirschi, Sandrine, Le Pavec, Jérôme, Mal, Hervé, Bergot, Emmanuel, Jouneau, Stéphane, Naccache, Jean-Marc, Revy, Patrick, Boutboul, David, Peffault de la Tour, Régis, Wemeau-Stervinou, Lidwine, Philit, Francois, Cordier, Jean-François, Thabut, Gabriel, Crestani, Bruno, and Cottin, Vincent
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- 2015
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19. Germline Mutations of Telomere-Related Genes are a Major Risk Factor for Liver Disease: A Multicentric Transversal Study
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Sidali, Sabrina, primary, Borie, Raphaël, additional, Sicre de Fontbrune, Flore, additional, El Husseini, Kinan, additional, Rautou, Pierre-Emmanuel, additional, Lainey, Elodie, additional, Goria, Odile, additional, Crestani, Bruno, additional, Cadranel, Jacques, additional, Cottin, Vincent, additional, Bunel, Vincent, additional, Dumortier, Jérôme, additional, Jacquemin, Emmanuel, additional, Reboux, Noémi, additional, Hirschi, Sandrine, additional, Bourdin, Arnaud, additional, Meszaros, Magdalena, additional, Dharancy, Sébastien, additional, Hilaire, Sophie, additional, Mallet, Vincent, additional, Reynaud-Gaubert, Martine, additional, Terriou, Louis, additional, Gottrand, Frédéric, additional, Abou Chahla, Wadih, additional, Kahn, Jean-Emmanuel, additional, Carrier, Paul, additional, Saliba, Faouzi, additional, Rubbia-Brandt, Laura, additional, Aubert, John-David, additional, Elkrief, Laure, additional, de Ledinghen, Victor, additional, Abergel, Armand, additional, Tournilhac, Olivier, additional, Houssel, Pauline, additional, Jouneau, Stéphane, additional, Wemeau, Ludivine, additional, Bergeron, Anne, additional, Leblanc, Thierry, additional, Ollivier-Hourmand, Isabelle, additional, Nguyen-Khac, Eric, additional, Morisse-Pradier, Hélène, additional, Ba, Ibrahima, additional, Boileau, Catherine, additional, Roulot-Thoraval, Françoise, additional, Vilgrain, Valérie, additional, Bureau, Christophe, additional, Nunes, Hilario, additional, Naccache, Jean-Marc, additional, Durand, François, additional, Francoz, Claire, additional, Roulot, Dominique, additional, Valla, Dominique-Charles, additional, Paradis, Valérie, additional, Kannengiesser, Caroline, additional, and Plessier, Aurélie, additional
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- 2023
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20. Lung Cancer in Combined Pulmonary Fibrosis and Emphysema: A Series of 47 Western Patients
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Girard, Nicolas, Marchand-Adam, Sylvain, Naccache, Jean-Marc, Borie, Raphael, Urban, Thierry, Jouneau, Stéphane, Marchand, Eric, Ravel, Anne-Claire, Kiakouama, Lize, Etienne-Mastroianni, Bénédicte, Cadranel, Jacques, Cottin, Vincent, and Cordier, Jean-François
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- 2014
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21. Invasive mechanical ventilation in patients with fibrosing interstitial pneumonia
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Gaudry, Stephane, Vincent, François, Rabbat, Antoine, Nunes, Hilario, Crestani, Bruno, Naccache, Jean Marc, Wolff, Michel, Thabut, Gabriel, Valeyre, Dominique, Cohen, Yves, and Mal, Hervé
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- 2014
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22. Rituximab for auto-immune alveolar proteinosis, a real life cohort study
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Soyez, Berenice, Borie, Raphael, Menard, Cedric, Cadranel, Jacques, Chavez, Leonidas, Cottin, Vincent, Gomez, Emmanuel, Marchand-Adam, Sylvain, Leroy, Sylvie, Naccache, Jean-Marc, Nunes, Hilario, Reynaud-Gaubert, Martine, Savale, Laurent, Tazi, Abdellatif, Wemeau-Stervinou, Lidwine, Debray, Marie-Pierre, and Crestani, Bruno
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- 2018
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23. Endobronchial ultrasound-guided transbronchial needle aspiration is feasible, safe, and reaches a 90 % diagnostic yield in patients with hypoxemic acute respiratory failure
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Decavèle, Maxens, Gounant, Valérie, Fleury Feith, Jocelyne, Febvre, Michel, Naccache, Jean-Marc, Parrot, Antoine, and Fartoukh, Muriel
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Acute respiratory distress syndrome -- Care and treatment -- Diagnosis ,Health care industry - Abstract
Author(s): Maxens Decavèle [sup.1] [sup.2], Valérie Gounant [sup.2] [sup.3] [sup.4], Jocelyne Fleury Feith [sup.2] [sup.5], Michel Febvre [sup.2] [sup.3], Jean-Marc Naccache [sup.2] [sup.3], Antoine Parrot [sup.1] [sup.2] [sup.3], Muriel Fartoukh [...]
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- 2016
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24. Recommandations pratiques pour le diagnostic et la prise en charge de la fibrose pulmonaire idiopathique – Actualisation 2021. Version intégrale
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Cottin, Vincent, Bonniaud, Philippe, Cadranel, Jacques, Crestani, Bruno, Jouneau, Stéphane, Marchand-Adam, Sylvain, Nunes, Hilario, Wémeau-Stervinou, Lidwine, Bergot, Emmanuel, Blanchard, Elodie, Borie, Raphaël, Bourdin, Arnaud, Chenivesse, Cécile, Clément, Annick, Gomez, Emmanuel, Gondouin, Anne, Hirschi, Sandrine, Lebargy, François, Marquette, Charles-Hugo, Montani, David, Prévot, Grégoire, Quetant, Sébastien, Reynaud-Gaubert, Martine, Salaun, Mathieu, Sanchez, Olivier, Trumbic, Bruno, Berkani, Karim, Brillet, Pierre-Yves, Campana, Marion, Chalabreysse, Lara, Chatté, Gérard, Debieuvre, Didier, Ferretti, Gilbert, Fourrier, Jean-Michel, Just, Nicolas, Kambouchner, Marianne, Legrand, Bertrand, Le Guillou, Frédéric, Lhuillier, Jean-Pierre, Mehdaoui, Anas, Naccache, Jean-Marc, Paganon, Catherine, Rémy-Jardin, Martine, Si-Mohamed, Salim, Terrioux, Philippe, Infections Virales et Pathologie Comparée - UMR 754 (IVPC), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre national de référence des maladies pulmonaires rares [Lyon] (CRMPM), Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Agro Dijon, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Service de Pneumologie Soins Intensifs, Appareillage Respiratoire [CHU de Dijon], CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Hôpital Avicenne [AP-HP], Institut Coeur Poumon [CHU Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), CHU Pessac, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Maladies génétiques d'expression pédiatrique (U933), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Nouvel Hôpital Civil de Strasbourg, Centre Hospitalier Universitaire de Reims (CHU Reims), Hôpital Pasteur [Nice] (CHU), Institut de Recherche sur le Cancer et le Vieillissement (IRCAN), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Hypertension arterielle pulmonaire physiopathologie et innovation thérapeutique, Centre Chirurgical Marie Lannelongue (CCML)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre Hospitalier Universitaire [Grenoble] (CHU), CHU Marseille, Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA), Centre d'Investigation Clinique [CHU Rouen] (CIC Rouen), Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Hypoxie et Poumon : pneumopathologies fibrosantes, modulations ventilatoires et circulatoires (H&P), UFR SMBH-Université Sorbonne Paris Nord, Centre Hospitalier Régional d'Orléans (CHRO), Hospices Civils de Lyon (HCL), Centre Hospitalier Emile Muller [Mulhouse] (CH E.Muller Mulhouse), Groupe Hospitalier de Territoire Haute Alsace (GHTHA), Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier Eure-Seine - Hôpital d'Evreux - Vernon (Evreux), Groupe Hospitalier Paris Saint-Joseph (hpsj), Services de Pneumologie, Exploration Fonctionnelle Respiratoire et Cardiologie (Hôpital Louis Pradel), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Association pour l’amélioration de la prise en charge des maladies pulmonaires rares, Hospices Civils de Lyon, and Université Claude Bernard Lyon 1.
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Biopsy ,Biopsie ,[SDV]Life Sciences [q-bio] ,Fibrose pulmonaire ,Pneumopathie interstitielle commune ,Interstitial lung disease ,Common interstitial lung disease ,Pneumopathie interstitielle diffuse ,Pulmonary fibrosis - Abstract
National audience; BACKGROUND: Since the previous French guidelines were published in 2017, substantial additional knowledge about idiopathic pulmonary fibrosis has accumulated. METHODS: Under the auspices of the French-speaking Learned Society of Pulmonology and at the initiative of the coordinating reference center, practical guidelines for treatment of rare pulmonary diseases have been established. They were elaborated by groups of writers, reviewers and coordinators with the help of the OrphaLung network, as well as pulmonologists with varying practice modalities, radiologists, pathologists, a general practitioner, a head nurse, and a patients’ association. The method was developed according to rules entitled "Good clinical practice" in the overall framework of the "Guidelines for clinical practice" of the official French health authority (HAS), taking into account the results of an online vote using a Likert scale. RESULTS: After analysis of the literature, 54 recommendations were formulated, improved, and validated by the working groups. The recommendations covered a wide-ranging aspects of the disease and its treatment: epidemiology, diagnostic modalities, quality criteria and interpretation of chest CT, indication and modalities of lung biopsy, etiologic workup, approach to familial disease entailing indications and modalities of genetic testing, evaluation of possible functional impairments and prognosis, indications for and use of antifibrotic therapy, lung transplantation, symptom management, comorbidities and complications, treatment of chronic respiratory failure, diagnosis and management of acute exacerbations of fibrosis. CONCLUSION: These evidence-based guidelines are aimed at guiding the diagnosis and the management in clinical practice of idiopathic pulmonary fibrosis.; Contexte :Depuis les précédentes recommandations françaises publiées en 2017, les connaissances concernant la fibrose pulmonaire idiopathique ont évolué sur de nombreux aspects.Méthodes :Des recommandations pratiques ont été établies à l’initiative du Centre coordonnateur de référence des maladies pulmonaires rares, sous l’égide de la Société de Pneumologie de Langue Française, par un groupe de coordination, un groupe de rédaction, et un groupe de lecture, impliquant l’ensemble du réseau OrphaLung, des pneumologues de divers modes d’exercice, des radiologues, des pathologistes, un médecin généraliste, un cadre de santé, et une association de patients. La méthode a respecté les règles d’élaboration des « Bonnes pratiques cliniques » selon la méthode des « Recommandations pour la pratique clinique » de la Haute Autorité de Santé, incluant un vote en ligne selon une échelle Likert.Résultats :Après une analyse bibliographique, 54 recommandations ont été formulées, améliorées, puis validées par les groupes de travail, portant sur des aspects multiples de la maladie : épidémiologie, modalités diagnostiques, critères de qualité et interprétation du scanner thoracique, indication et réalisation de la biopsie pulmonaire, bilan étiologique, modalités et indications de l’enquête familiale et de l’analyse génétique, évaluation du retentissement fonctionnel et du pronostic, indication et emploi des médicaments antifibrosants, transplantation pulmonaire, prise en charge des symptômes, comorbidités et complications, traitement de l’insuffisance respiratoire chronique, diagnostic et prise en charge des exacerbations aiguës de fibrose.Conclusion :Ces recommandations fondées sur les preuves sont destinées à guider le diagnostic et la prise en charge pratique de la fibrose pulmonaire idiopathique.
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- 2022
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25. Outcome and prognostic factors in a French cohort of patients with myositis-associated interstitial lung disease
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Obert, Julie, Freynet, Olivia, Nunes, Hilario, Brillet, Pierre-Yves, Miyara, Makoto, Dhote, Robin, Valeyre, Dominique, and Naccache, Jean-Marc
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- 2016
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26. Acute Exacerbation of Idiopathic Pulmonary Fibrosis
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Naccache, Jean-Marc, Cadranel, Jacques, and Nunes, Hilario
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- 2017
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27. Determinants of survival after lung transplantation in telomerase-related gene mutation carriers: A retrospective cohort
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Phillips-Houlbracq, Mathilde, Mal, Hervé, Cottin, Vincent, Gauvain, Clément, Beier, Fabian, Sicre de Fontbrune, Flore, Sidali, Sabrina, Mornex, Jean François, Hirschi, Sandrine, Roux, Antoine, Weisenburger, Gaelle, Roussel, Arnaud, Wémeau-Stervinou, Lidwine, Le Pavec, Jérôme, Pison, Christophe, Marchand Adam, Sylvain, Froidure, Antoine, Lazor, Romain, Naccache, Jean-Marc, Jouneau, Stéphane, Nunes, Hilario, Reynaud-Gaubert, Martine, Le Borgne, Aurélie, Boutboul, David, Ba, Ibrahima, Boileau, Catherine, Crestani, Bruno, Kannengiesser, Caroline, and Borie, Raphaël
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- 2022
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28. Determinants of survival after lung transplantation in telomerase-related gene mutation carriers: A retrospective cohort.
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UCL - (SLuc) Service de pneumologie, Phillips-Houlbracq, Mathilde, Mal, Hervé, Cottin, Vincent, Gauvain, Clément, Beier, Fabian, Sicre de Fontbrune, Flore, Sidali, Sabrina, Mornex, Jean François, Hirschi, Sandrine, Roux, Antoine, Weisenburger, Gaelle, Roussel, Arnaud, Wémeau-Stervinou, Lidwine, Le Pavec, Jérôme, Pison, Christophe, Marchand Adam, Sylvain, Froidure, Antoine, Lazor, Romain, Naccache, Jean-Marc, Jouneau, Stéphane, Nunes, Hilario, Reynaud-Gaubert, Martine, Le Borgne, Aurélie, Boutboul, David, Ba, Ibrahima, Boileau, Catherine, Crestani, Bruno, Kannengiesser, Caroline, Borie, Raphaël, OrphaLung Network, UCL - (SLuc) Service de pneumologie, Phillips-Houlbracq, Mathilde, Mal, Hervé, Cottin, Vincent, Gauvain, Clément, Beier, Fabian, Sicre de Fontbrune, Flore, Sidali, Sabrina, Mornex, Jean François, Hirschi, Sandrine, Roux, Antoine, Weisenburger, Gaelle, Roussel, Arnaud, Wémeau-Stervinou, Lidwine, Le Pavec, Jérôme, Pison, Christophe, Marchand Adam, Sylvain, Froidure, Antoine, Lazor, Romain, Naccache, Jean-Marc, Jouneau, Stéphane, Nunes, Hilario, Reynaud-Gaubert, Martine, Le Borgne, Aurélie, Boutboul, David, Ba, Ibrahima, Boileau, Catherine, Crestani, Bruno, Kannengiesser, Caroline, Borie, Raphaël, and OrphaLung Network
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Carriers of germline telomerase-related gene (TRG) mutations can show poor prognosis, with an increase in common hematological complications after lung transplantation (LT) for pulmonary fibrosis. The aim of this study was to describe the outcomes after LT in recipients carrying a germline TRG mutation and to identify the predictors of survival. In a multicenter cohort of LT patients, we retrospectively reviewed those carrying pathogenic TRG variations (n = 38; TERT, n = 23, TERC, n = 9, RTEL1, n = 6) between 2009 and 2018. The median age at LT was 54 years (interquartile range [IQR] 46-59); 68% were male and 71% had idiopathic pulmonary fibrosis. During the diagnosis of pulmonary fibrosis, 28 (74%) had a hematological disease, including eight with myelodysplasia. After a median follow-up of 26 months (IQR 15-46), 38 patients received LT. The overall post-LT median survival was 3.75 years (IQR 1.8-NA). The risk of death after LT was increased for patients with myelodysplasia (HR 4.1 [95% CI 1.5-11.5]) or short telomere (HR 2.2 [1.0-5.0]) before LT. After LT, all patients had anemia, 66% had thrombocytopenia, and 39% had neutropenia. Chronic lung allograft dysfunction frequency was 29% at 4 years. The present findings support the use of LT in TRG mutation carriers without myelodysplasia. Hematological evaluation should be systematically performed before LT.
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- 2022
29. Interstitial lung diseases associated with mutations of poly(A)-specific ribonuclease: A multicentre retrospective study
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Philippot, Quentin, Kannengiesser, Caroline, Debray, Marie Pierre, Gauvain, Clément, Ba, Ibrahima, Vieri, Margherita, Gondouin, Anne, Naccache, Jean Marc, Reynaud-Gaubert, Martine, Uzunhan, Yurdagul, Bondue, Benjamin, Israël-Biet, Dominique, Dieudé, Philippe, Fourrage, Cécile, Lainey, Elodie, Manali, Effrosyne, Papiris, Spyridon, Wemeau, Lidwine, Hirschi, Sandrine, Mal, Hervé, Nunes, Hilario, Schlemmer, Frédéric, Blanchard, Elodie, Beier, Fabian, Cottin, Vincent, Crestani, Bruno, Borie, Raphael, Philippot, Quentin, Kannengiesser, Caroline, Debray, Marie Pierre, Gauvain, Clément, Ba, Ibrahima, Vieri, Margherita, Gondouin, Anne, Naccache, Jean Marc, Reynaud-Gaubert, Martine, Uzunhan, Yurdagul, Bondue, Benjamin, Israël-Biet, Dominique, Dieudé, Philippe, Fourrage, Cécile, Lainey, Elodie, Manali, Effrosyne, Papiris, Spyridon, Wemeau, Lidwine, Hirschi, Sandrine, Mal, Hervé, Nunes, Hilario, Schlemmer, Frédéric, Blanchard, Elodie, Beier, Fabian, Cottin, Vincent, Crestani, Bruno, and Borie, Raphael
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Background and objective: Poly(A)-specific ribonuclease (PARN) mutations have been associated with familial pulmonary fibrosis. This study aims to describe the phenotype of patients with interstitial lung disease (ILD) and heterozygous PARN mutations. Methods: We performed a retrospective, observational, non-interventional study of patients with an ILD diagnosis and a pathogenic heterozygous PARN mutation followed up in a centre of the OrphaLung network. Results: We included 31 patients (29 from 16 kindreds and two sporadic patients). The median age at ILD diagnosis was 59 years (range 54 to 63). In total, 23 (74%) patients had a smoking history and/or fibrogenic exposure. The pulmonary phenotypes were heterogenous, but the most frequent diagnosis was idiopathic pulmonary fibrosis (n = 12, 39%). Haematological abnormalities were identified in three patients and liver disease in two. In total, 21 patients received a specific treatment for ILD: steroids (n = 13), antifibrotic agents (n = 11), immunosuppressants (n = 5) and N-acetyl cysteine (n = 2). The median forced vital capacity decline for the whole sample was 256 ml/year (range −363 to −148). After a median follow-up of 32 months (range 18 to 66), 10 patients had died and six had undergone lung transplantation. The median transplantation-free survival was 54 months (95% CI 29 to ∞). Extra-pulmonary features were less frequent with PARN mutation than telomerase reverse transcriptase (TERT) or telomerase RNA component (TERC) mutation. Conclusion: IPF is common among individuals with PARN mutation, but other ILD subtypes may be observed., SCOPUS: ar.j, info:eu-repo/semantics/published
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- 2022
30. Effect of diagnosis level of certainty on adherence to antibiotics' guidelines in ED patients with pneumonia: a post-hoc analysis of an interventional trial.
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Tubiana, Sarah, Epelboin, Loïc, Casalino, Enrique, Naccache, Jean-Marc, Feydy, Antoine, Khalil, Antoine, Hausfater, Pierre, Duval, Xavier, and Claessens, Yann-Erick
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- 2023
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31. Sarcoïdose médiastinopulmonaire
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Nunes, Hilario, Uzunhan, Yurdagul, Freynet, Olivia, Naccache, Jean-Marc, Bouvry, Diane, Brillet, Pierre-Yves, and Valeyre, Dominique
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- 2010
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32. Authors' reply
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Naccache, Jean-Marc, primary, Cachanado, Marine, additional, Rousseau, Alexandra, additional, and Nunes, Hilario, additional
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- 2022
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33. Early Chest Computed Tomography Scan to Assist Diagnosis and Guide Treatment Decision for Suspected Community-acquired Pneumonia
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Claessens, Yann-Erick, Debray, Marie-Pierre, Tubach, Florence, Brun, Anne-Laure, Rammaert, Blandine, Hausfater, Pierre, Naccache, Jean-Marc, Ray, Patrick, Choquet, Christophe, Carette, Marie-France, Mayaud, Charles, Leport, Catherine, and Duval, Xavier
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- 2015
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34. FoxP3 + Regulatory T Cells Suppress Early Stages of Granuloma Formation but Have Little Impact on Sarcoidosis Lesions
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Taflin, Cécile, Miyara, Makoto, Nochy, Dominique, Valeyre, Dominique, Naccache, Jean-Marc, Altare, Frédéric, Salek-Peyron, Pascale, Badoual, Cécile, Bruneval, Patrick, Haroche, Julien, Mathian, Alexis, Amoura, Zahir, Hill, Gary, and Gorochov, Guy
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- 2009
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35. Exposure to inorganic particles in paediatric sarcoidosis: the PEDIASARC study
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Nathan, Nadia, primary, Montagne, Marie-Emeline, additional, Macchi, Odile, additional, Rosental, Paul-André, additional, Chauveau, Simon, additional, Jeny, Florence, additional, Sesé, Lucile, additional, Abou Taam, Rola, additional, Brocvielle, Manon, additional, Brouard, Jacques, additional, Catinon, Mickaël, additional, Chapelon-Abric, Catherine, additional, Cohen-Aubart, Fleur, additional, Delacourt, Christophe, additional, Delestrain, Céline, additional, Deschildre, Antoine, additional, Dossier, Antoine, additional, Epaud, Ralph, additional, Haroche, Julien, additional, Houdouin, Véronique, additional, Israel-Biet, Dominique, additional, Juvin, Karine, additional, Le Jeune, Sylvain, additional, Lionnet, Francois, additional, Meinzer, Ulrich, additional, Mittaine, Marie, additional, Nunes, Hilario, additional, Mattioni, Sarah, additional, Naccache, Jean-Marc, additional, Odièvre, Marie-Hélène, additional, Vincent, Michel, additional, Clement, Annick, additional, Valeyre, Dominique, additional, and Cavalin, Catherine, additional
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- 2021
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36. RCT Abstract - Cyclophosphamide added to glucocorticoids in acute exacerbation of idiopathic pulmonary fibrosis (EXAFIP): a randomized, double-blind, placebo-controlled, phase 3 trial
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Naccache, Jean-Marc, primary, Jouneau, Stephane, additional, Didier, Morgane, additional, Borie, Raphaël, additional, Cachanado, Marine, additional, Bourdin, Arnaud, additional, Reynaud-Gaubert, Martine, additional, Bonniaud, Philippe, additional, Israel-Biet, Dominique, additional, Prevot, Gregoire, additional, Hirschi, Sandrine, additional, Lebargy, Francois, additional, Marchand-Adam, Sylvain, additional, Bautin, Nathalie, additional, Traclet, Julie, additional, Gomez, Emmanuel, additional, Leroy, Sylvie, additional, Gagnadoux, Frederic, additional, Rivière, Frederic, additional, Bergot, Emmanuel, additional, Gondouin, Anne, additional, Blanchard, Elodie, additional, Parrot, Antoine, additional, Blanc, Francois-Xavier, additional, Chabrol, Alexandre, additional, Dominique, Stephane, additional, Gibelin, Aude, additional, Tazi, Abdellatif, additional, Berard, Laurence, additional, Brillet, Pierre-Yves, additional, Debray, Marie-Pierre, additional, Rousseau, Alexandra, additional, Kerjouan, Malorie, additional, Freynet, Olivia, additional, Dombret, Marie-Christine, additional, Gamez, Anne-Sophie, additional, Nieves, Ana, additional, Beltramo, Guillaume, additional, Pastré, Jean, additional, Le Borgne-Krams, Aurélie, additional, Dégot, Tristan, additional, Launois, Claire, additional, Plantier, Laurent, additional, Wémeau-Stervinou, Lidwine, additional, Cadranel, Jacques, additional, Chenivesse, Cécile, additional, Valeyre, Dominique, additional, Crestani, Bruno, additional, Cottin, Vincent, additional, Simon, Tabassome, additional, and Nunes, Hilario, additional
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- 2021
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37. Mineral exposures in pediatric sarcoidosis
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Nathan, Nadia, primary, Montagne, Marie-Emeline, additional, Macchi, Odile, additional, Rosental, Paul-André, additional, Chauveau, Simon, additional, Jeny, Florence, additional, Sesé, Lucile, additional, Abou Taam, Rola, additional, Brouard, Jacques, additional, Catinon, Mickaël, additional, Chapelon-Abric, Catherine, additional, Cohen Aubart, Fleur, additional, Delacourt, Christophe, additional, Delestrain, Céline, additional, Deschildre, Antoine, additional, Dossier, Antoine, additional, Epaud, Ralph, additional, Haroche, Julien, additional, Houdouin, Véronique, additional, Israel-Biet, Dominique, additional, Juvin, Karine, additional, Le Jeune, Sylvain, additional, Lionnet, François, additional, Meinzer, Ulrich, additional, Mittaine, Marie, additional, Nunes, Hilario, additional, Mattioni, Sarah, additional, Naccache, Jean-Marc, additional, Odièvre, Marie-Hélène, additional, Vincent, Michel, additional, Clement, Annick, additional, Valeyre, Dominique, additional, and Cavalin, Catherine, additional
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- 2021
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38. Is Telomeropathy the Explanation for Combined Pulmonary Fibrosis and Emphysema Syndrome?: Report of a Family with TERT Mutation
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Nunes, Hilario, Monnet, Isabelle, Kannengiesser, Caroline, Uzunhan, Yurdagul, Valeyre, Dominique, Kambouchner, Marianne, and Naccache, Jean-Marc
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- 2014
39. Safety and efficacy of pirfenidone and nintedanib in patients with idiopathic pulmonary fibrosis and carrying a telomere-related gene mutation
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Justet, Aurelien Klay, Dymph Porcher, Raphael Cottin, Vincent Ahmad, Kais Molina, Maria Molina Nunes, Hilario and Reynaud-Gaubert, Martine Naccache, Jean Marc Manali, Effrosyni and Froidure, Antoine Jouneau, Stephane Wemeau, Lidwine and Andrejak, Claire Gondouin, Anne Hirschi, Sandrine Blanchard, Elodie Bondue, Benjamin Bonniaud, Philippe Tromeur, Cecile and Prevot, Gregoire Marchand-Adam, Sylvain Funke-Chambour, Manuela Gamez, Anne Sophie Ba, Ibrahima Papiris, Spyridon and Grutters, Jan Crestani, Bruno van Moorsel, Coline and Kannengiesser, Caroline Borie, Raphael OrphaLung Network
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- 2021
40. ESSAI RANDOMISÉ POUR ÉVALUER L’EFFICACITÉ ET LA SÉCURITÉ DE TRAITEMENTS CHEZ DES PATIENTS AMBULATOIRES ATTEINTS DE COVID-19 AYANT DES FACTEURS DE RISQUE ESSAI COVERAGE FRANCE : PRÉSENTATION DU PROTOCOLE
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Onaisi, Racha, Duvignaud, Alexandre, Nguyen Binh, Antoine, Dupouy, Julie, Chastang, Julie, Le Bel, Josselin, Landman, Roland, Naccache, Jean Marc, Lefèvre, Benjamin, Piroth, Lionel, Binquet, C, Makinson, Alain, Darnaud, Thomas, Begue, Cyril, Weiss, Laurence, Richert, Laura, Anglaret, Xavier, Denis, Malvy, Joseph, Jean Philippe, Druais, Pierre Louis, Darmon, David, Ral, Cedric, Lhomme, Edouard, Saint-Lary, Olivier, Université de Bordeaux (UB), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Groupe hospitalier Pellegrin, Global Health in the Global South (GHiGS), Institut de Recherche pour le Développement (IRD)- Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Sorbonne Université (SU), Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'investigation clinique de Toulouse (CIC 1436), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Pôle Santé publique et médecine publique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre hospitalier Saint-Joseph [Paris], Centre Hospitalier Universitaire de Nancy (CHU Nancy), CHU Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques (CIC-EC), Université de Bourgogne (UB)-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre Hospitalier Bastia (CHB), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Immunologie humaine, physiopathologie & immunothérapie (HIPI (UMR_S_976 / U976)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), CIC Bordeaux, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Statistics In System biology and Translational Medicine (SISTM), Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)- Bordeaux population health (BPH), Haute Autorité de Santé [Saint-Denis La Plaine] (HAS), Université Côte d'Azur (UCA), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Nantes (UN), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, and Dupuis, Christine
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treatment ,[SDV]Life Sciences [q-bio] ,protocols ,trial ,Internal ,controlled ,clinical ,[SDV] Life Sciences [q-bio] ,early ,randomized ,outpatient ,Medicine ,General ,Covid-19 - Abstract
Context. The Covid-19 pandemic is of unprecedented magnitude and has had major social and health consequences. Primary care professionals, mainly general practitioners, ensure the care of most patients with Covid-19. An early-stage treatment administered to patients with risk factors for developing a severe disease could reduce hospitalization and death rates. No treatment is currently validated in this indication. Objectives. To evaluate the safety and efficacy of experimental candidate agents delivered in outpatient settings to reduce the risk of hospitalization or death in at-risk patients with early-stage proven Covid-19 and no indication for hospital admission. Methods. Multicentric, open-label, multi-arm, multi-stage (MAMS) randomized controlled trial with a pilot tolerability and safety phase, and a clinical efficacy phase. Efficacy will be determined by the proportion of participants who have an indication for hospital admission, administration of acute oxygen therapy (because of Covid-19) or who decease between D0 and D14 in the experimental treatment group compared to the control group. Expected results. This trial will assess the tolerance and efficacy of diverse treatments administered at an early stage of Covid-19, in patients with risk factors of developing a severe disease. It will also provide information that can contribute to increase primary care actors' ability to conduct clinical trials at the national level., Contexte. La pandémie de Covid-19 a eu d’importantes répercussions sanitaires et sociales. Les acteurs de soins primaires, en particulier les spécialistes de médecine générale, prennent en charge la majorité des patients atteints de Covid-19. Un traitement précoce initié en première ligne, notamment chez les patients à risque d’aggravation, pourrait réduire les taux d’hospitalisation et de décès. Aucun traitement n’est actuellement validé dans cette indication.Objectif. Évaluer l’efficacité et la tolérance de traitements expérimentaux administrés à un stade précoce, en ambulatoire, dans le but de diminuer le risque de développer une forme sévère de la maladie chez des patients atteints de Covid-19 ayant des facteurs de risque d’aggravation et qui n’ont pas de critères d’hospitalisation.Méthodes. Essai thérapeutique contrôlé randomisé multicentrique, en ouvert, multi-bras, multi-étapes (MAMS) comprenant une phase pilote d’évaluation de la tolérance et une phase d’évaluation de l’efficacité. L’efficacité sera évaluée par la proportion de participants ayant eu une indication d’hospitalisation, une indication d’oxygénothérapie aiguë (en raison de la Covid-19), ou décédés entre J0 et J14 dans le groupe traitement expérimental par rapport au groupe témoin. Résultats attendus. Cet essai permettra d’évaluer la tolérance et l’efficacité de l’administration précoce de divers traitements dans le cadre de la Covid-19 chez des patients à risque de développer des formes graves. Il fournira également des informations susceptibles d’améliorer la recherche clinique interventionnelle impliquant la personne humaine en soins primaires et sa structuration.
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- 2021
41. Determinants of survival after lung transplantation in telomerase-related gene mutation carriers: A retrospective cohort
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Phillips-Houlbracq, Mathilde, Mal, Hervé, Cottin, Vincent, Gauvain, Clément, Beier, Fabian, Sicre de Fontbrune, Flore, Sidali, Sabrina, Mornex, Jean François, Hirschi, Sandrine, Roux, Antoine, Weisenburger, Gaelle, Roussel, Arnaud, Wémeau-Stervinou, Lidwine, Le Pavec, Jérôme, Pison, Christophe, Marchand Adam, Sylvain, Froidure, Antoine, Lazor, Romain, Naccache, Jean-Marc, Jouneau, Stéphane, Nunes, Hilario, Reynaud-Gaubert, Martine, Le Borgne, Aurélie, Boutboul, David, Ba, Ibrahima, Boileau, Catherine, Crestani, Bruno, Kannengiesser, Caroline, Borie, Raphaël, OrphaLung Network, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service de pneumologie, Physiopathologie et Epidémiologie des Maladies Respiratoires (PHERE (UMR_S_1152 / U1152)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Référence des Maladies Pulmonaires Rares [Hôpital Louis Pradel - HCL], Hôpital Louis Pradel [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Infections Virales et Pathologie Comparée - UMR 754 (IVPC), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Lille, Rheinisch-Westfälische Technische Hochschule Aachen University (RWTH), Hopital Saint-Louis [AP-HP] (AP-HP), Hôpital Beaujon [AP-HP], Les Hôpitaux Universitaires de Strasbourg (HUS), Hôpital Foch [Suresnes], Université Paris-Saclay, Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Cliniques Universitaires Saint-Luc [Bruxelles], Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Hôpital Avicenne [AP-HP], Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Hôpital Nord [CHU - APHM], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Rheinisch-Westfälische Technische Hochschule Aachen (RWTH), Hypertension arterielle pulmonaire physiopathologie et innovation thérapeutique, Centre chirurgical Marie Lannelongue-Institut National de la Santé et de la Recherche Médicale (INSERM), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), Hôpital Larrey [Toulouse], CHU Toulouse [Toulouse], Université d'Angers (UA)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
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Male ,medicine.medical_specialty ,lung disease ,Anemia ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,transplant social worker ,030204 cardiovascular system & hematology ,Neutropenia ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Interquartile range ,Internal medicine ,Pulmonary fibrosis ,medicine ,lung transplantation ,Immunology and Allergy ,Lung transplantation ,Humans ,Pharmacology (medical) ,Telomerase ,pulmonology ,Retrospective Studies ,Transplantation ,Lung ,business.industry ,fibrosis ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Idiopathic Pulmonary Fibrosis ,practice ,3. Good health ,medicine.anatomical_structure ,030228 respiratory system ,clinical research ,Cohort ,Mutation ,business - Abstract
Carriers of germline telomerase-related gene (TRG) mutations can show poor prognosis, with an increase in common hematological complications after lung transplantation (LT) for pulmonary fibrosis. The aim of this study was to describe the outcomes after LT in recipients carrying a germline TRG mutation and to identify the predictors of survival. In a multicenter cohort of LT patients, we retrospectively reviewed those carrying pathogenic TRG variations (n = 38; TERT, n = 23, TERC, n = 9, RTEL1, n = 6) between 2009 and 2018. The median age at LT was 54 years (interquartile range [IQR] 46-59); 68% were male and 71% had idiopathic pulmonary fibrosis. During the diagnosis of pulmonary fibrosis, 28 (74%) had a hematological disease, including eight with myelodysplasia. After a median follow-up of 26 months (IQR 15-46), 38 patients received LT. The overall post-LT median survival was 3.75 years (IQR 1.8-NA). The risk of death after LT was increased for patients with myelodysplasia (HR 4.1 [95% CI 1.5-11.5]) or short telomere (HR 2.2 [1.0-5.0]) before LT. After LT, all patients had anemia, 66% had thrombocytopenia, and 39% had neutropenia. Chronic lung allograft dysfunction frequency was 29% at 4 years. The present findings support the use of LT in TRG mutation carriers without myelodysplasia. Hematological evaluation should be systematically performed before LT.
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- 2021
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42. Determinants of survival after lung transplantation in telomerase-related gene mutation carriers: A retrospective cohort.
- Author
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UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service de pneumologie, Phillips-Houlbracq, Mathilde, Mal, Hervé, Cottin, Vincent, Gauvain, Clément, Beier, Fabian, Sicre de Fontbrune, Flore, Sidali, Sabrina, Mornex, Jean François, Hirschi, Sandrine, Roux, Antoine, Weisenburger, Gaelle, Roussel, Arnaud, Wémeau-Stervinou, Lidwine, Le Pavec, Jérôme, Pison, Christophe, Marchand Adam, Sylvain, Froidure, Antoine, Lazor, Romain, Naccache, Jean-Marc, Jouneau, Stéphane, Nunes, Hilario, Reynaud-Gaubert, Martine, Le Borgne, Aurélie, Boutboul, David, Ba, Ibrahima, Boileau, Catherine, Crestani, Bruno, Kannengiesser, Caroline, Borie, Raphaël, OrphaLung Network, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service de pneumologie, Phillips-Houlbracq, Mathilde, Mal, Hervé, Cottin, Vincent, Gauvain, Clément, Beier, Fabian, Sicre de Fontbrune, Flore, Sidali, Sabrina, Mornex, Jean François, Hirschi, Sandrine, Roux, Antoine, Weisenburger, Gaelle, Roussel, Arnaud, Wémeau-Stervinou, Lidwine, Le Pavec, Jérôme, Pison, Christophe, Marchand Adam, Sylvain, Froidure, Antoine, Lazor, Romain, Naccache, Jean-Marc, Jouneau, Stéphane, Nunes, Hilario, Reynaud-Gaubert, Martine, Le Borgne, Aurélie, Boutboul, David, Ba, Ibrahima, Boileau, Catherine, Crestani, Bruno, Kannengiesser, Caroline, Borie, Raphaël, and OrphaLung Network
- Abstract
Carriers of germline telomerase-related gene (TRG) mutations can show poor prognosis, with an increase in common hematological complications after lung transplantation (LT) for pulmonary fibrosis. The aim of this study was to describe the outcomes after LT in recipients carrying a germline TRG mutation and to identify the predictors of survival. In a multicenter cohort of LT patients, we retrospectively reviewed those carrying pathogenic TRG variations (n = 38; TERT, n = 23, TERC, n = 9, RTEL1, n = 6) between 2009 and 2018. The median age at LT was 54 years (interquartile range [IQR] 46-59); 68% were male and 71% had idiopathic pulmonary fibrosis. During the diagnosis of pulmonary fibrosis, 28 (74%) had a hematological disease, including eight with myelodysplasia. After a median follow-up of 26 months (IQR 15-46), 38 patients received LT. The overall post-LT median survival was 3.75 years (IQR 1.8-NA). The risk of death after LT was increased for patients with myelodysplasia (HR 4.1 [95% CI 1.5-11.5]) or short telomere (HR 2.2 [1.0-5.0]) before LT. After LT, all patients had anemia, 66% had thrombocytopenia, and 39% had neutropenia. Chronic lung allograft dysfunction frequency was 29% at 4 years. The present findings support the use of LT in TRG mutation carriers without myelodysplasia. Hematological evaluation should be systematically performed before LT.
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- 2021
43. Safety and efficacy of pirfenidone and nintedanib in patients with idiopathic pulmonary fibrosis and carrying a telomere-related gene mutation.
- Author
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UCL - (SLuc) Service de pneumologie, Justet, Aurélien, Klay, Dymph, Porcher, Raphaël, Cottin, Vincent, Ahmad, Kais, Molina Molina, Maria, Nunes, Hilario, Reynaud-Gaubert, Martine, Naccache, Jean Marc, Manali, Effrosyni, Froidure, Antoine, Jouneau, Stéphane, Wemeau, Lidwine, Andrejak, Claire, Gondouin, Anne, Hirschi, Sandrine, Blanchard, Elodie, Bondue, Benjamin, Bonniaud, Philippe, Tromeur, Cécile, Prévot, Grégoire, Marchand-Adam, Sylvain, Funke-Chambour, Manuela, Gamez, Anne Sophie, Ba, Ibrahima, Papiris, Spyridon, Grutters, Jan, Crestani, Bruno, van Moorsel, Coline, Kannengiesser, Caroline, Borie, Raphaël, OrphaLung Network, UCL - (SLuc) Service de pneumologie, Justet, Aurélien, Klay, Dymph, Porcher, Raphaël, Cottin, Vincent, Ahmad, Kais, Molina Molina, Maria, Nunes, Hilario, Reynaud-Gaubert, Martine, Naccache, Jean Marc, Manali, Effrosyni, Froidure, Antoine, Jouneau, Stéphane, Wemeau, Lidwine, Andrejak, Claire, Gondouin, Anne, Hirschi, Sandrine, Blanchard, Elodie, Bondue, Benjamin, Bonniaud, Philippe, Tromeur, Cécile, Prévot, Grégoire, Marchand-Adam, Sylvain, Funke-Chambour, Manuela, Gamez, Anne Sophie, Ba, Ibrahima, Papiris, Spyridon, Grutters, Jan, Crestani, Bruno, van Moorsel, Coline, Kannengiesser, Caroline, Borie, Raphaël, and OrphaLung Network
- Abstract
No abstract available
- Published
- 2021
44. Safety and efficacy of pirfenidone and nintedanib in patients with idiopathic pulmonary fibrosis and carrying a telomere-related gene mutation.
- Author
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Justet, Aurélien, Klay, Dymph, Porcher, Raphaël, Cottin, Vincent, Ahmad, Kais, Molina Molina, Maria, Nunes, Hilario, Reynaud-Gaubert, Martine, Naccache, Jean Marc, Manali, Effrosyni E.D., Froidure, Antoine, Jouneau, Stéphane, Stervinou-Wemeau, Lidwine, Andrejak, Claire, Gondouin, Anne, Hirschi, Sandrine, Blanchard, Elodie, Bondue, Benjamin, Bonniaud, Philippe, Tromeur, Cécile, Prévot, Grégoire, Marchand-Adam, Sylvain, Funke-Chambour, Manuela, Gamez, Anne Sophie, Ba, Ibrahima, Papiris, Spyridon, Grutters, Jan JC, Crestani, Bruno, Van Moorsel, Coline, Kannengiesser, Caroline, Borie, Raphael, OrphaLung Network, Justet, Aurélien, Klay, Dymph, Porcher, Raphaël, Cottin, Vincent, Ahmad, Kais, Molina Molina, Maria, Nunes, Hilario, Reynaud-Gaubert, Martine, Naccache, Jean Marc, Manali, Effrosyni E.D., Froidure, Antoine, Jouneau, Stéphane, Stervinou-Wemeau, Lidwine, Andrejak, Claire, Gondouin, Anne, Hirschi, Sandrine, Blanchard, Elodie, Bondue, Benjamin, Bonniaud, Philippe, Tromeur, Cécile, Prévot, Grégoire, Marchand-Adam, Sylvain, Funke-Chambour, Manuela, Gamez, Anne Sophie, Ba, Ibrahima, Papiris, Spyridon, Grutters, Jan JC, Crestani, Bruno, Van Moorsel, Coline, Kannengiesser, Caroline, Borie, Raphael, and OrphaLung Network
- Abstract
SCOPUS: le.j, info:eu-repo/semantics/published
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- 2021
45. Sarcoidosis in HIV-infected patients in the era of highly active antiretroviral therapy
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Foulon, Guillaume, Wislez, Marie, Naccache, Jean-Marc, Blanc, Francois-Xavier, Rabbat, Antoine, Israel-Biet, Dominique, Valeyre, Dominique, Mayaud, Charles, and Cadranel, Jacques
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Health ,Health care industry - Published
- 2004
46. Acute Exacerbation of Idiopathic Pulmonary Fibrosis: Outcome and Prognostic Factors
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Simon-Blancal, Virginie V., Freynet, Olivia O., Nunes, Hilario H., Bouvry, Diane D., Naggara, Nicolas N., Brillet, Pierre-Yves P.-Y., Denis, Damien D., Cohen, Yves Y., Vincent, François F., Valeyre, Dominique D., and Naccache, Jean-Marc J.-M.
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- 2012
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47. Safety and efficacy of pirfenidone and nintedanib in patients with idiopathic pulmonary fibrosis and carrying a telomere-related gene mutation
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Justet, Aurélien, primary, Klay, Dymph, additional, Porcher, Raphaël, additional, Cottin, Vincent, additional, Ahmad, Kais, additional, Molina Molina, Maria, additional, Nunes, Hilario, additional, Reynaud-Gaubert, Martine, additional, Naccache, Jean Marc, additional, Manali, Effrosyni, additional, Froidure, Antoine, additional, Jouneau, Stéphane, additional, Wemeau, Lidwine, additional, Andrejak, Claire, additional, Gondouin, Anne, additional, Hirschi, Sandrine, additional, Blanchard, Elodie, additional, Bondue, Benjamin, additional, Bonniaud, Philippe, additional, Tromeur, Cécile, additional, Prévot, Grégoire, additional, Marchand-Adam, Sylvain, additional, Funke-Chambour, Manuela, additional, Gamez, Anne Sophie, additional, Ba, Ibrahima, additional, Papiris, Spyridon, additional, Grutters, Jan, additional, Crestani, Bruno, additional, van Moorsel, Coline, additional, Kannengiesser, Caroline, additional, and Borie, Raphaël, additional
- Published
- 2020
- Full Text
- View/download PDF
48. Interstitial lung diseases associated with mutations of poly(A)-specific ribonuclease: a multicentric retrospective cohort study
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Philippot, Quentin, primary, Kannengiesser, Caroline, additional, Ba, Ibrahima, additional, Gondouin, Anne, additional, Naccache, Jean-Marc, additional, Reynaud-Gobert, Martine, additional, Uzunhan, Yurdagul, additional, Bondue, Benjamin, additional, Israel Biet, Dominique, additional, Manali, Effrosyne, additional, Papiris, Spyros, additional, Wemeau, Lidwine, additional, Hirschi, Sandrine, additional, Mal, Hervé, additional, Nunes, Hilario, additional, Schlemmer, Frédéric, additional, Rigaud, Matthieu, additional, Cottin, Vincent, additional, Crestani, Bruno, additional, and Borie, Raphaël, additional
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- 2020
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49. Liver involvement in patients with telomere-related genes mutations: prevalence, clinical, radiological, pathological features, outcome and risk factors
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Sidali, Sabrina, primary, Borie, Raphaël, additional, Flore, Sicre, additional, Lainey, Elodie, additional, Rautou, Pierre-Emmanuel, additional, Cadranel, Jacques, additional, Naccache, Jean-marc, additional, Cottin, Vincent, additional, Dumortier, Jérôme, additional, Jacquemin, Emmanuel, additional, Baptiste, Nousbaum Jean, additional, Hirschi, Sandrine, additional, Bourdin, Arnaud, additional, Meszaros, Magdalena, additional, Dharancy, Sebastien, additional, Hilaire, Sophie, additional, Mallet, Vincent, additional, Martine, Reynaud-Gaubert, additional, Terriou, Louis, additional, Gottrand, Frédéric, additional, Chahla, Wadih Abou, additional, Khan, Jean Emmanuel, additional, Carrier, Paul, additional, Saliba, Faouzi, additional, Rubbia-Brandt, Laura, additional, Elkrief, Laure, additional, de Lédinghen, Victor, additional, Abergel, Armand, additional, Olivier, Tournilhac, additional, Chouik, Yasmina, additional, Coupier, Antoine, additional, Leblanc, Thierry, additional, Ollivier-Hourmand, Isabelle, additional, Khac, Eric Nguyen, additional, Morisse-Pradier, Hélène, additional, El Husseini, Kinan, additional, Goria, Odile, additional, Ibrahima, Ba, additional, Roulot, Dominique, additional, Bureau, Christophe, additional, Nunes, Hilario, additional, Valla, Dominique, additional, Paradis, Valérie, additional, Caroline, Kannengiesser, additional, and Plessier, Aurélie, additional
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- 2020
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50. Interstitial Lung Disease Associated with Lung Cancer: A Case–Control Study
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Gibiot, Quentin, primary, Monnet, Isabelle, additional, Levy, Pierre, additional, Brun, Anne-Laure, additional, Antoine, Martine, additional, Chouaïd, Christos, additional, Cadranel, Jacques, additional, and Naccache, Jean-Marc, additional
- Published
- 2020
- Full Text
- View/download PDF
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