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205 results on '"Naegel, Steffen"'

1. Quantitative whole-body muscle MRI in idiopathic inflammatory myopathies including polymyositis with mitochondrial pathology: indications for a disease spectrum

Author

Zierer, Lea-Katharina, Naegel, Steffen, Schneider, Ilka, Kendzierski, Thomas, Kleeberg, Kathleen, Koelsch, Anna Katharina, Scholle, Leila, Schaefer, Christoph, Naegel, Arne, Zierz, Stephan, Otto, Markus, Stoltenburg-Didinger, Gisela, Kraya, Torsten, Stoevesandt, Dietrich, and Mensch, Alexander

Published
2024
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3. Long-term efficacy and safety of nusinersen in adults with 5q spinal muscular atrophy: a prospective European multinational observational study

Author

Günther, René, Wurster, Claudia Diana, Brakemeier, Svenja, Osmanovic, Alma, Schreiber-Katz, Olivia, Petri, Susanne, Uzelac, Zeljko, Hiebeler, Miriam, Thiele, Simone, Walter, Maggie C., Weiler, Markus, Kessler, Tobias, Freigang, Maren, Lapp, Hanna Sophie, Cordts, Isabell, Lingor, Paul, Deschauer, Marcus, Hahn, Andreas, Martakis, Kyriakos, Steinbach, Robert, Ilse, Benjamin, Rödiger, Annekathrin, Bellut, Julia, Nentwich, Julia, Zeller, Daniel, Muhandes, Mohamad Tareq, Baum, Tobias, Christoph Koch, Jan, Schrank, Bertold, Fischer, Sophie, Hermann, Andreas, Kamm, Christoph, Naegel, Steffen, Mensch, Alexander, Weber, Markus, Neuwirth, Christoph, Lehmann, Helmar C., Wunderlich, Gilbert, Stadler, Christian, Tomforde, Maike, George, Annette, Groß, Martin, Pechmann, Astrid, Kirschner, Janbernd, Türk, Matthias, Schimmel, Mareike, Bernert, Günther, Martin, Pascal, Rauscher, Christian, Meyer zu Hörste, Gerd, Baum, Petra, Löscher, Wolfgang, Flotats-Bastardas, Marina, Köhler, Cornelia, Probst-Schendzielorz, Kristina, Goldbach, Susanne, Schara-Schmidt, Ulrike, Müller-Felber, Wolfgang, Lochmüller, Hanns, von Velsen, Otgonzul, Kleinschnitz, Christoph, Ludolph, Albert C., and Hagenacker, Tim

Published
2024
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11. Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache: a multicentre, double-blind, randomised controlled trial

Author

Obermann, Mark, Nägel, Steffen, Ose, Claudia, Sonuc, Nilüfer, Scherag, André, Storch, Peter, Gaul, Charly, Böger, Andreas, Kraya, Torsten, Jansen, Jan-Peter, Straube, Andreas, Freilinger, Tobias, Kaube, Holger, Jürgens, Tim P, Diener, Hans-Christoph, Katsarava, Zaza, Kleinschnitz, Christoph, and Holle, Dagny

Published
2021
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18. Role of Functional Neuroimaging in Primary Headache Disorders

Author

Naegel, Steffen and Obermann, Mark

Subjects
Headache -- Diagnosis -- Development and progression, Neuroimaging -- Methods, Health
Abstract

Byline: Steffen. Naegel, Mark. Obermann Background: Key structures for the pathophysiology of primary headache disorders such as migraine, cluster headache, and other trigeminal autonomic cephalalgias were identified by imaging in [...]

Published
2021

19. Improvements in walking distance during nusinersen treatment : a prospective 3-year SMArtCARE registry study

Author

Pechmann, Astrid, Naegel, Steffen, and [Und Viele Weitere]

Abstract

Background and objectives: Disease progression in patients with spinal muscular atrophy (SMA) has changed dramatically within the past years due to the approval of three different disease-modifying treatments. Nusinersen was the first drug to be approved for the treatment of SMA patients. Clinical trials provided data from infants with SMA type 1 and children with SMA type 2, but there is still insufficient evidence and only scarcely reported long-term experience for nusinersen treatment in ambulant patients. Here, we report data from the SMArtCARE registry of ambulant patients under nusinersen treatment with a follow-up period of up to 38 months. Methods: SMArtCARE is a disease-specific registry in Germany, Austria and Switzerland. Data are collected as real-world data during routine patient visits. Our analysis included all patients under treatment with nusinersen able to walk independently before start of treatment with focus on changes in motor function. Results: Data from 231 ambulant patients were included in the analysis. During the observation period, 31 pediatric walkers (27.2%) and 31 adult walkers (26.5%) experienced a clinically meaningful improvement of≥30 m in the 6-Minute-Walk-Test. In contrast, only five adult walkers (7.7%) showed a decline in walking distance≥30 m, and two pediatric walkers (1.8%) lost the ability to walk unassisted under treatment with nusinersen. HFMSE and RULM scores improved in pediatric and remained stable in adult patients. Conclusion: Our data demonstrate a positive effect of nusinersen treatment in most ambulant pediatric and adult SMA patients. We not only observed a stabilization of disease progression or lack of deterioration, but clinically meaningful improvements in walking distance.

Published
2023
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20. Cognitive deficits in patients with peripheral vestibular dysfunction

Author

Obermann, Mark, Gebauer, Alexander, Arweiler-Harbeck, Diana, Lang, Stephan, Seilheimer, Bernd, Kleinschnitz, Christoph, Diener, Hans Christoph, Holle, Dagny, and Naegel, Steffen

Subjects
Medizin
Abstract

Background and purpose: Previous studies demonstrated cognitive deficits in patients with peripheral vestibulopathy (PVP) with dysfunction of spatial navigation and orientation, but also documented cognitive decline in nonspatial abilities. This study evaluates cognitive deficits in patients with unilateral vestibulopathy (UVP) as well as bilateral vestibulopathy (BVP) in multiple cognitive domains using common screening tests to reliably detect these deficits in clinical practice. Methods: This prospective study compared patients with UVP and BVP to age- and sex-matched healthy controls (HC). Tests included the Alzheimer's Disease Assessment Scale (ADAS), Mini-Mental Status Examination (MMSE), Trail Making Test Part A and B, Clock Drawing Task, Executive Interview-25 (EXIT25), Dementia Detection (DemTect), and the Judgment of Line Orientation (JLO). The Montgomery-Åsberg Depression Rating Scale was used to control for depression. Videonystagmography objectively reconfirmed PVP. The Vertigo Symptoms Scale and the Dizziness Handicap Inventory were used to assess for symptom severity and restrictions of activities of daily living. Results: Eighty-one patients (65 UVP, 16 BVP) were compared to 55 HC. Patients showed impairment in ADAS, MMSE, DemTect, EXIT25, and JLO. No differences between UVP and BVP were detected. The relative risk (RR) estimates of developing cognitive deficits following PVP were increased. The RR for the ADAS was higher in BVP (RR = 4.91, 95% confidence interval [CI] = 1.87–12.9, p = 0.001) than in UVP (RR = 3.75, 95% CI = 1.65–8.51, p = 0.002), but was similar for the MMSE and DemTect between groups. Conclusions: Patients with PVP showed deficits in multiple cognitive domains including nonspatial cognitive abilities. Vestibulopathy could be a risk factor for the development of cognitive impairment. in press

Published
2023

24. Study Design and Protocol of a Randomized Controlled Trial of the Efficacy of a Smartphone-Based Therapy of Migraine (SMARTGEM)

Author

Oliveira Gonçalves, Ana Sofia, primary, Laumeier, Inga, additional, Hofacker, Maxi Dana, additional, Raffaelli, Bianca, additional, Burow, Philipp, additional, Dahlem, Markus A., additional, Heintz, Simon, additional, Jürgens, Tim Patrick, additional, Naegel, Steffen, additional, Rimmele, Florian, additional, Scholler, Simon, additional, Kurth, Tobias, additional, Reuter, Uwe, additional, and Neeb, Lars, additional

Published
2022
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35. Additional file 1 of Efficacy and safety of fremanezumab in clinical trial participants aged ≥60 years with episodic or chronic migraine: pooled results from 3 randomized, double-blind, placebo-controlled phase 3 studies

Author

Nahas, Stephanie J., Naegel, Steffen, Cohen, Joshua M., Ning, Xiaoping, Janka, Lindsay, Campos, Verena Ramirez, Krasenbaum, Lynda J., Holle-Lee, Dagny, Kudrow, David, and Lampl, Christian

Abstract

Additional file 1. Types of CV Medical History at Baseline.

Published
2021
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38. No structural brain alterations in new daily persistent headache – a cross sectional VBM/SBM study.

Author

Naegel, Steffen, Zeller, Julia, Hougard, Anders, Weise, Christopher Michael, Zuelow, Stefan, Kleinschnitz, Christoph, Obermann, Mark, Solbach, Kasja, and Holle, Dagny

Subjects
*PRIMARY headache disorders, *HEADACHE, *VOXEL-based morphometry
Abstract

Objective: To identify grey matter alterations in patients suffering new daily persistent headache to enrich the pathophysiological concept of this rare headache disorder characterised by a distinct, clearly remembered onset and its instant chronification. Method: Magnetic resonance-based voxel-based and surface-based morphometry was used to investigate 23 patients suffering from new daily persistent headache and 23 age- and gender-matched healthy controls with 1.5 Tesla MRI. Independent statistical analysis was performed at three sites using statistical parametric mapping, as well as FSL(FMRIB Software Library)-based approaches. Results: No grey matter changes were detected using this sophisticated and cross-checked method. Conclusion: The absence of structural brain changes in patients with new daily persistent headache contribute to the recent discussion regarding structural alterations in primary headache disorders in general and does not provide evidence for grey matter changes being associated with the pathophysiology of new daily persistent headache. Future research will have to determine the underlying pathophysiological mechanisms of this disorder. [ABSTRACT FROM AUTHOR]

Published
2022
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41. sj-pdf-2-cep-10.1177_0333102420977183 - Supplemental material for Prevalence and risk factors of migraine and non-migraine headache in older people – results of the Heinz Nixdorf Recall study

Author

Schramm, Sara, Tenhagen, Isabell, Schmidt, Börge, Holle-Lee, Dagny, Naegel, Steffen, Katsarava, Zaza, Karl-Heinz Jöckel, and Moebus, Susanne

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), 110306 Endocrinology, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-pdf-2-cep-10.1177_0333102420977183 for Prevalence and risk factors of migraine and non-migraine headache in older people – results of the Heinz Nixdorf Recall study by Sara Schramm, Isabell Tenhagen, Börge Schmidt, Dagny Holle-Lee, Steffen Naegel, Zaza Katsarava, Karl-Heinz Jöckel and Susanne Moebus in Cephalalgia

Published
2020
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42. sj-pdf-1-cep-10.1177_0333102420977183 - Supplemental material for Prevalence and risk factors of migraine and non-migraine headache in older people – results of the Heinz Nixdorf Recall study

Author

Schramm, Sara, Tenhagen, Isabell, Schmidt, Börge, Holle-Lee, Dagny, Naegel, Steffen, Katsarava, Zaza, Karl-Heinz Jöckel, and Moebus, Susanne

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), 110306 Endocrinology, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-pdf-1-cep-10.1177_0333102420977183 for Prevalence and risk factors of migraine and non-migraine headache in older people – results of the Heinz Nixdorf Recall study by Sara Schramm, Isabell Tenhagen, Börge Schmidt, Dagny Holle-Lee, Steffen Naegel, Zaza Katsarava, Karl-Heinz Jöckel and Susanne Moebus in Cephalalgia

Published
2020
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47. Contributors

Author

Adams, Harold P., Jr., Adeoye, Opeolu, Albers, Gregory W., Alexandrov, Andrei V., Amin-Hanjani, Sepideh, An, Hongyu, Anderson, Craig S., Anrather, Josef, Aparicio, Hugo J., Arai, Ken, Aronowski, Jaroslaw, Atchaneeyasakul, Kunakorn, Audebert, Heinrich, Auer, Roland N., Awad, Issam A., Ay, Hakan, Baltan, Selva, Balu, Ramani, Behbahani, Mandana, Benavente, Oscar R., Bershad, Eric M., Berthaud, Jimmy V., Blackburn, Spiros L., Bonati, Leo H., Bösel, Julian, Bousser, Marie Germaine, Broderick, Joseph P., Brown, Martin M., Brown, Wendy, Brust, John C.M., Bushnell, Cheryl, Canhão, Patrícia, Caplan, Louis R., Carrión-Penagos, Julián, Castellanos, Mar, Caunca, Michelle R., Chabriat, Hugues, Chamorro, Angel, Chen, Jieli, Chen, Jun, Chopp, Michael, Christorforids, Greg, Connolly, E. Sander, Jr., Cramer, Steven C., Cucchiara, Brett L., Czap, Alexandra L., Dannenbaum, Mark J., Davis, Patricia H., Dawson, Ted M., Dawson, Valina L., Day, Arthur L., De Silva, T. Michael, de Sousa, Diana Aguiar, Del Brutto, Victor J., del Zoppo, Gregory J., Derdeyn, Colin P., Di Tullio, Marco R., Diener, Hans Christoph, Diringer, Michael N., Dobkin, Bruce H., Dzialowski, Imanuel, Elkind, Mitchell S.V., Elm, Jordan, Feigin, Valery L., Ferro, José Manuel, Field, Thalia S., Fischer, Marlene, Fornage, Myriam, Furie, Karen L., Garcia-Bonilla, Lidia, Giannotta, Steven L., Gobin, Y. Pierre, Goldberg, Mark P., Goldstein, Larry B., Gonzales, Nicole R., Greer, David M., Grotta, James C., Guo, Ruiming, Gutierrez, Jose, Harmel, Peter, Howard, George, Howard, Virginia J., Hwang, Jee-Yeon, Iadecola, Costantino, Jahan, Reza, Jickling, Glen C., Joutel, Anne, Kasner, Scott E., Katan, Mira, Kellner, Christopher P., Khan, Muhib, Kidwell, Chelsea S., Kim, Helen, Kim, Jong S., Kircher, Charles E., Krings, Timo, Krishnamurthi, Rita V., Kurth, Tobias, Lansberg, Maarten G., Levy, Elad I., Liebeskind, David S., Liew, Sook-Lei, Lin, David J., Lisle, Benjamin, Lo, Eng H., Lyden, Patrick D., Maki, Takakuni, Maragkos, Georgios A., Marosfoi, Miklos, McCullough, Louise D., Meckler, Jason M., Meschia, James Frederick, Messé, Steven R., Mocco, J, Mokin, Maxim, Mooney, Michael A., Morgenstern, Lewis B., Moskowitz, Michael A., Mullen, Michael T., Nägel, Steffen, Nedergaard, Maiken, Neira, Justin A., Newman, Sarah, Nicholson, Patrick J., Norrving, Bo, O’Donnell, Martin, Ofengeim, Dimitry, Ogata, Jun, Ogilvy, Christopher S., Orrù, Emanuele, Ortega-Gutiérrez, Santiago, Padrick, Matthew Maximillian, Parsha, Kaushik, Parsons, Mark, Patel, Neil V., Patel, Virendra I., Pawlikowska, Ludmila, Pérez, Adriana, Perez-Pinzon, Miguel A., Picard, John M., Polster, Sean P., Powers, William J., Puetz, Volker, Putaala, Jukka, Rabinovich, Margarita, Ransom, Bruce R., Roa, Jorge A., Rosenberg, Gary A., Rossitto, Christina P., Rundek, Tatjana, Russin, Jonathan J., Sacco, Ralph L., Safouris, Apostolos, Samaniego, Edgar A., Sansing, Lauren H., Satani, Nikunj, Sattenberg, Ronald J., Saver, Jeffrey L., Savitz, Sean I., Schmidt, Christian, Seshadri, Sudha, Sharma, Vijay K., Sharp, Frank R., Sheth, Kevin N., Siddiqi, Omar K., Singhal, Aneesh B., Sobey, Christopher G., Sommer, Clemens J., Spetzler, Robert F., Stapleton, Christopher J., Strickland, Ben A., Su, Hua, Suarez, José I., Takayama, Hiroo, Tarsia, Joseph, Tatlisumak, Turgut, Thomas, Ajith J., Thompson, John W., Tsivgoulis, Georgios, Tournier-Lasserve, Elizabeth, Vidal, Gabriel, Wakhloo, Ajay K., Weksler, Babette B., Willey, Joshua Z., Wintermark, Max, Wong, Lawrence K.S., Xi, Guohua, Xu, Jinchong, Yaghi, Shadi, Yamaguchi, Takenori, Yang, Tuo, Yasaka, Masahiro, Zahuranec, Darin B., Zhang, Feng, Zhang, John H., Zheng, Zhitong, Zukin, R. Suzanne, and Zweifler, Richard M.

Published
2022
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