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137 results on '"Nagarajan, Arun"'

2. Genomic Predictors Associated With Exceptional Response to Systemic Therapy in Advanced Pancreatic Cancer

Author

Kamath, Suneel D., Roopkumar, Joanna, Ni, Ying, Shen, Minqian, Bejarano, Pablo, Allende, Daniela, Nagarajan, Arun, Nguyen, Tim, Dergham, Bachar, Shepard, Dale, Shapiro, Marc A., McNamara, Michael J., Estfan, Bassam N., Nair, Kanika G., and Khorana, Alok A.

Subjects
Oncology, Experimental -- Health aspects -- Analysis, Metastasis -- Care and treatment -- Development and progression, Cancer -- Care and treatment -- Genetic aspects -- Research, Pancreatic cancer -- Development and progression -- Care and treatment, Health, Cleveland Clinic
Abstract

Introduction: Exceptional response to therapy is rare in patients with advanced pancreatic cancer. This study explored potential genomic differences between typical and exceptional responses that could confer more favorable biology. Methods: We included exceptional responders and controls with advanced pancreatic cancer from Cleveland Clinic from April 2013 to August 2017. Exceptional responders were defined as patients with an overall survival of more than 18 months for metastatic disease and more than 24 months for locally advanced disease. Clinical data were obtained, and next-generation sequencing was performed. Statistical analyses comparing the 2 groups were performed using descriptive statistics, the Kaplan-Meier method, and the log-rank test. Results: The study comprised 4 exceptional responders and 6 controls. Both groups were well balanced in age, sex, race, and treatment regimens. Exceptional responders had significantly fewer nonsynonymous mutations than controls (2.25 vs 5.17; P = .014). A mutation count of less than 3 was associated with significantly better progression-free survival (17.2 vs 2.3 months; P = .002) and overall survival (29.4 vs 4.6 months; P = .013). Tumor mutational burden did not differ between exceptional responders and controls (4.88 vs 5.70 mut/Mb; P = .39). Conclusion: A lower number of nonsynonymous mutations may correlate with exceptional outcomes in patients with pancreatic cancer. These findings should encourage future studies into genomic signatures of exceptional response., Introduction Pancreatic cancer is associated with poor outcomes at any stage. However, a very small number of patients--approximately 3% of those with metastatic disease--experience long-term survival through 5 years and [...]

Published
2023

11. Prognostic value of circulating tumor DNA (ctDNA) testing in patients (pts) with rectal cancer after neoadjuvant therapy (NAT) and surgery.

Author

Chakrabarti, Sakti, primary, Cohen, Stacey A., additional, Tin, Antony, additional, Dangl, Autumn, additional, Aushev, Vasily N., additional, Tejani, Mohamedtaki Abdulaziz, additional, Chandana, Sreenivasa R, additional, Malla, Midhun, additional, Landmann, Ron G., additional, Sharma, Vivek R., additional, Botta, Gregory P., additional, Nagarajan, Arun, additional, Azzi, Georges, additional, Cho, May Thet, additional, Dayyani, Farshid, additional, Hanna, Diana L., additional, Jurdi, Adham A, additional, Liu, Minetta C., additional, Dasari, Arvind, additional, and Kasi, Pashtoon Murtaza, additional

Published
2024
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12. Mechanically Tunable Slippery Behavior on Soft Poly(dimethylsiloxane) (PDMS) Based Anisotropic Wrinkles Infused with Lubricating Fluid

Author

Roy, Pritam Kumar, Pant, Reeta, Nagarajan, Arun Kumar, and Khare, Krishnacharya

Subjects
Condensed Matter - Soft Condensed Matter, Physics - Chemical Physics
Abstract

We demonstrate a novel technique to fabricate mechanically tunable slippery surfaces using one dimensional (anisotropic) elastic wrinkles. Such wrinkles show tunable topography (amplitude) on the application of mechanical strain. Following Nepenthes pitcher plants, lubricating fluid infused solid surfaces show excellent slippery behavior for test liquid drops. Therefore combining the above two i.e. infusing suitable lubricating fluid on elastic wrinkles would enable us to fabricate mechanically tunable slippery surfaces. Completely stretched (flat) wrinkles have uniform coating of lubricating fluid whereas completely relaxed (full amplitude) wrinkles have most of the lubricating oil in the wrinkle grooves. Therefore water drops on completely stretched surface show excellent slippery behavior whereas on completely relaxed surface they show very poor slippery behavior. Therefore continuous variation of wrinkle stretching provide reversibly tunable slippery behavior on such system. Since the winkles are one dimensional, they show anisotropic tunability of slippery behavior depending upon whether test liquid drops slip parallel or perpendicular to the wrinkles., Comment: 18 pages, 5 figures

Published
2016

13. Enhanced Slippery Behavior and Stability of Lubricating Fluid Infused Nanostructured Surfaces

Author

Pant, Reeta, Ujjain, Sanjeev Kumar, Nagarajan, Arun Kumar, and Khare, Krishnacharya

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

Stability of lubricating fluid infused slippery surfaces is a concern for scientists and engineers and attempts are being made for its improvement. Lubricating oil coated slippery surface for aqueous drops is one of the important candidates in this class and their stability needs be improved to make them useful for practical applications. Cloaking of water drops with thin lubricant layer results in the loss of lubricant leading to deterioration of slippery behavior. Surface roughness or porosity provides larger surface area to the lubricating fluid and would to affect the stability of the lubricating film. Here we report the effect of surface roughness, from tens of nanometer to few microns, on the stability of slippery surface. Samples with small nanoscale roughness show improved performance in terms of contact angle hysteresis, critical tilt angle and slip velocity. Whereas large roughness samples show poorer performance compared to small nanoscale roughness and smooth samples. Small nanoscale roughness samples also show relatively slower deterioration against loss of lubricant during water flow. Once completely lost, the slippery behavior can be restored again simply by coating the sample again by the lubricating fluid., Comment: 19 pages, 6 figures

Published
2016
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14. Investigation of slippery behaviour of lubricating fluid coated smooth hydrophilic surfaces

Author

Pant, Reeta, Roy, Pritam Kumar, Nagarajan, Arun Kumar, and Khare, Krishnacharya

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

In the recent years many research groups have studied slippery properties on lubricating fluid infused rough surfaces using hydrophobic substrates. These surfaces show excellent slippery behaviour for water and other liquids. Here we demonstrate a simple method to fabricate stable slippery surfaces based on silicone oil coated hydrophilic samples. At room temperature, as prepared samples exhibit non-slippery behaviour due to sinking of water drops inside silicone oil layer because of inherently hydrophilic silicon substrate. Subsequent annealing at higher temperatures provides covalent bonding of silicone molecules at silicon surface making the surface hydrophobic which was confirmed by lubricant wash tests. So the silicone oil coated annealed samples show excellent water repellency, very low contact angle hysteresis and very good slippery behavior. But these surfaces show poor oil stability against drops flow due to cloaking of the oil around water drops which can be prevented by using drops of larger volume or continuous flow of water., Comment: 14 pages, 5 figures

Published
2015

15. Electrowetting on dielectrics on lubricating fluid based slippery surfaces with negligible hysteresis

Author

Barman, Jitesh, Nagarajan, Arun Kumar, and Khare, Krishnacharya

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

Low voltage electrowetting on dielectrics on substrates with thin layer of lubricating fluid to reduce contact angle hysteresis is reported here. On smooth and homogeneous solid surfaces, it is extremely difficult to reduce contact angle hysteresis (contact angle difference between advancing and receding drop volume cycle) and the electrowetting hysteresis (contact angle difference between advancing and receding voltage cycle) below 10{\deg}. On the other hand, electrowetting hysteresis on rough surfaces can be relatively large (>30{\deg}) therefore they are of no use for most of the fluidic devices. In the present report we demonstrate that using a thin layer of dielectric lubricating fluid on top of the solid dielectric surface results in drastic reduction in contact angle hysteresis as well as electrowetting hysteresis (< 2{\deg}) on smooth as well as rough surfaces. Subsequently fitting the Lippmann-Young electrowetting equation to the experimental electrowetting data reveal that the dielectric lubricating fluid layer is only responsible for smooth movement of the three phase contact line of the liquid drop and does not affect the effective specific capacitance of the system., Comment: 10 pages, 2 figures

Published
2015

20. Data from E3611—A Randomized Phase II Study of Ipilimumab at 3 or 10 mg/kg Alone or in Combination with High-Dose Interferon-α2b in Advanced Melanoma

Author

Tarhini, Ahmad A., primary, Lee, Sandra J., primary, Li, Xiaoxue, primary, Rao, Uma N.M., primary, Nagarajan, Arun, primary, Albertini, Mark R., primary, Mitchell, Jerry W., primary, Wong, Stuart J., primary, Taylor, Mark A., primary, Laudi, Noel, primary, Truong, Phu V., primary, Conry, Robert M., primary, and Kirkwood, John M., primary

Published
2023
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21. Table S1, Table S2 from E3611—A Randomized Phase II Study of Ipilimumab at 3 or 10 mg/kg Alone or in Combination with High-Dose Interferon-α2b in Advanced Melanoma

Author

Tarhini, Ahmad A., primary, Lee, Sandra J., primary, Li, Xiaoxue, primary, Rao, Uma N.M., primary, Nagarajan, Arun, primary, Albertini, Mark R., primary, Mitchell, Jerry W., primary, Wong, Stuart J., primary, Taylor, Mark A., primary, Laudi, Noel, primary, Truong, Phu V., primary, Conry, Robert M., primary, and Kirkwood, John M., primary

Published
2023
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22. Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer: ASCO Guideline

Author

Shah, Manish A., primary, Kennedy, Erin B., additional, Alarcon-Rozas, Ashley E., additional, Alcindor, Thierry, additional, Bartley, Angela N., additional, Malowany, Aubrey Belk, additional, Bhadkamkar, Nishin A., additional, Deighton, Dana C., additional, Janjigian, Yelena, additional, Karippot, Asha, additional, Khan, Uqba, additional, King, Daniel A., additional, Klute, Kelsey, additional, Lacy, Jill, additional, Lee, James J., additional, Mehta, Rutika, additional, Mukherjee, Sarbajit, additional, Nagarajan, Arun, additional, Park, Haeseong, additional, Saeed, Anwaar, additional, Semrad, Thomas J., additional, Shitara, Kohei, additional, Smyth, Elizabeth, additional, Uboha, Natalia V., additional, Vincelli, Melani, additional, Wainberg, Zev, additional, and Rajdev, Lakshmi, additional

Published
2023
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23. Liver Venous Deprivation for Rapid Liver Hypertrophy Before Major Hepatectomy: A Case Report

Author

John, Nathan, Montorfano, Lisandro, Nagarajan, Arun, Simpfendorfer, Conrad H, Wexner, Steven D, Amin, Parag, and Roy, Mayank

Abstract

Liver venous deprivation (LVD) is an emerging, minimally invasive strategy to induce rapid liver hypertrophy of the future liver remnant (FLR) before a major hepatectomy. LVD (aka “double vein embolization”) entails same-session percutaneous embolization of the portal and hepatic veins of the planned liver resection. This report discusses LVD’s utilization and technical challenges in managing a 49-year-old male with recurrent multifocal colorectal liver metastases (CRLM). The patient initially underwent neoadjuvant FOLFOX chemotherapy followed by a simultaneous laparoscopic sigmoid colectomy and liver surgery (microwave ablation of segment V and wedge resections of segment one and IVb), followed by completion of chemotherapy. The patient had an R0 resection with clear colon and liver surgical margins. Nine months after the initial surgery, the patient had a rise in tumor markers, and surveillance imaging demonstrated recurrence of liver metastases in segments I and V. LVD was performed by interventional radiology, which led to a 28% increase in FLR (segments II, III, and IV); initially measuring 464 cm3before LVD and measuring 594 cm3on post-procedure day 21. The patient underwent right hemi-hepatectomy and caudate resection on post-procedure day 29. The patient did not have any complications and was discharged on postoperative day 6. The patient remains disease-free with no evidence of recurrence at 12 months follow-up.

Published
2023
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31. Further structural characterization of ovine forestomach matrix and multi-layered extracellular matrix composites for soft tissue repair

Author

Smith, Matthew J, primary, Dempsey, Sandi G, additional, Veale, Robert WF, additional, Duston-Fursman, Claudia G, additional, Rayner, Chloe A F, additional, Javanapong, Chettha, additional, Gerneke, Dane, additional, Dowling, Shane G, additional, Bosque, Brandon A, additional, Karnik, Tanvi, additional, Jerram, Michael J, additional, Nagarajan, Arun, additional, Rajam, Ravinder, additional, Jowsey, Alister, additional, Cutajar, Samuel, additional, Mason, Isaac, additional, Stanley, Roderick G, additional, Campbell, Andrew, additional, Malmstrom, Jenny, additional, Miller, Chris H, additional, and May, Barnaby C H, additional

Published
2021
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34. Number of nonsynonymous genomic variants may correlate with prognosis in advanced pancreatic cancer.

Author

Kamath, Suneel Deepak, primary, Roopkumar, Joanna, additional, Ni, Ying, additional, Shen, Minqian, additional, Bejarano, Pablo, additional, Allende, Daniela, additional, Nagarajan, Arun, additional, Nguyen, Tim, additional, Dergham, Bachar, additional, Shepard, Dale Randall, additional, Shapiro, Marc A., additional, McNamara, Michael J., additional, Estfan, Bassam N., additional, Nair, Kanika G., additional, and Khorana, Alok A., additional

Published
2021
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37. Further structural characterization of ovine forestomach matrix and multi-layered extracellular matrix composites for soft tissue repair.

Author

Smith, Matthew J, Dempsey, Sandi G, Veale, Robert WF, Duston-Fursman, Claudia G, Rayner, Chloe A F, Javanapong, Chettha, Gerneke, Dane, Dowling, Shane G, Bosque, Brandon A, Karnik, Tanvi, Jerram, Michael J, Nagarajan, Arun, Rajam, Ravinder, Jowsey, Alister, Cutajar, Samuel, Mason, Isaac, Stanley, Roderick G, Campbell, Andrew, Malmstrom, Jenny, and Miller, Chris H

Subjects
EXTRACELLULAR matrix, HYALURONIC acid, COMPOSITE materials, CLINICAL indications, TISSUES
Abstract

Decellularized extracellular matrix (dECM)–based biomaterials are of great clinical utility in soft tissue repair applications due to their regenerative properties. Multi-layered dECM devices have been developed for clinical indications where additional thickness and biomechanical performance are required. However, traditional approaches to the fabrication of multi-layered dECM devices introduce additional laminating materials or chemical modifications of the dECM that may impair the biological functionality of the material. Using an established dECM biomaterial, ovine forestomach matrix, a novel method for the fabrication of multi-layered dECM constructs has been developed, where layers are bonded via a physical interlocking process without the need for additional bonding materials or detrimental chemical modification of the dECM. The versatility of the interlocking process has been demonstrated by incorporating a layer of hyaluronic acid to create a composite material with additional biological functionality. Interlocked composite devices including hyaluronic acid showed improved in vitro bioactivity and moisture retention properties. [ABSTRACT FROM AUTHOR]

Published
2022
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38. E3611—A Randomized Phase II Study of Ipilimumab at 3 or 10 mg/kg Alone or in Combination with High-Dose Interferon-α2b in Advanced Melanoma

Author

Tarhini, Ahmad A., primary, Lee, Sandra J., additional, Li, Xiaoxue, additional, Rao, Uma N.M., additional, Nagarajan, Arun, additional, Albertini, Mark R., additional, Mitchell, Jerry W., additional, Wong, Stuart J., additional, Taylor, Mark A., additional, Laudi, Noel, additional, Truong, Phu V., additional, Conry, Robert M., additional, and Kirkwood, John M., additional

Published
2019
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40. Total Neoadjuvant Treatment for Rectal Cancer: Preliminary Experience

Author

Gilshtein, Hayim, Ghuman, Amandeep, Dawoud, Mirelle, Yellinek, Shlomo, Kent, Ilan, Sharp, Stephen P., Nagarajan, Arun, and Wexner, Steven D.

Abstract

Introduction Administration of chemotherapeutic regimens such as FOLFOX or CAPEOX with chemoradiation in the neoadjuvant setting, termed total neoadjuvant treatment (TNT), was introduced in recent years. By increasing the complete pathologic and clinical responses, patients with locally advanced rectal cancer may have better oncologic outcomes and potentially abstain from undergoing a proctectomy.Methods All patients who underwent TNT at a single National Accreditation Program for Rectal Cancer accredited referral center were included. A retrospective analysis was performed using a computerized Institutional Review Board-approved database. Patient demographics, diagnostic workup, treatment regimens, and surgical and pathological reports were reviewed. Complete pathological response was the primary outcome. Univariable and multivariable logistic regression analyses were performed to identify potential factors predisposing to complete pathological response.Results Thirty patients met the inclusion criteria, 14(46.6%) of whom had complete pathologic response. There was no difference in baseline demographic characteristics between patients who achieved complete pathological response and those who did not. Pathology revealed a 92% intact mesorectum rate in the complete pathologic response group and a mean of 24 harvested lymph nodes in the entire study cohort. Both univariable and multivariable logistic regression analyses failed to demonstrate statistically significant factors predicting complete pathologic response, magnetic resonance imaging (MRI) tumor size, and posttreatment MRI lymph node positivity.Conclusion TNT is safe and efficient for patients with locally advanced rectal cancer. It increases complete pathological and clinical response rates and may more widely evolve to be the treatment of choice in this group of patients in the near future.

Published
2021
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41. A randomized phase II study of ipilimumab at 3 (ipi3) or 10 mg/kg (ipi10) alone or in combination with high dose interferon-alfa (HDI) in advanced melanoma (E3611).

Author

Tarhini, Ahmad A., primary, Lee, Sandra J., additional, Rao, Uma N. M., additional, Nagarajan, Arun, additional, Albertini, Mark R., additional, Mitchell, Jerry W, additional, Wong, Stuart J., additional, Taylor, Mark A., additional, Laudi, Noel, additional, Truong, Phu Van, additional, Conry, Robert Martin, additional, and Kirkwood, John M., additional

Published
2017
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