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Introduction: COVID-19 started in Wuhan, China. About 36.5% manifest with CNS symptoms like- Acute Ischemic Stroke, Guillain-barre Syndrome, Seizures and Encephalopathy. Since the pandemic has started many newer treatment modalities have been incorporated like antibiotics, antiviral agents and also as an adjuvant therapy with vitamin supplements are being used. Knowing the above treatment modalities various complications was noted and one of the major unpredictable events such as seizures/ convulsions, so to deduce the reason this study was taken up. Patients studied: COVID isolation ward with history of high grade fever, headache, breathlessness and myalgia for 4 days On the Day 5 of illness (2nd post admission day) they developed first episode of Seizure of General Tonic Clonic Seizures. The confirmed COVID-19 - RT PCR positive patients were admitted with history of high grade fever, headache, breathlessness and myalgia for 3-4 days, with the age of the patients being in the range of 40- 55 years, with no past history of seizures/ trauma/ head injury / ear discharge, whose vitals were stable and no neurological deficits found on physical examination done on the day of admission. An initially Empirical antibiotic was started with Tab. Azithromycin 500mg OD- PO for 5days with Cap. Oseltamivir 75mg BD for 3 days followed by supportive medication such as Tab. Cetirizine 10mg, Vitamin supplementation with Tab. Vit C 500mg and Tab. Zinc 50mg were given to the RT PCR positive patients. Conclusion: The probability of alternative diagnosis is unlikely and low with the background of the pandemic setting. The temporal association positive RT PCR and the onset of seizures coinciding 2 days after onset of symptoms and the mild laboratory changes may be one of the contributory factors to the seizures, with zinc supplementation being the other causative factor suspected to potentiate seizure activity.

Background: Vaccines used in vaccination program are considered safe and effective but immunization safety has become as important as the efficacy of vaccination program. The objective of the study was to detect Adverse Events Following Immunization (AEFIs) to inactivated COVID vaccine administered to a Health Care worker in Karnataka. Methods: The prospective active vaccine safety surveillance study enrolled eligible Health Care workers (HCWs) in the age group 18–60 years receiving vaccination from the immunization centre at HIMS Hospital, Hassan. Study participants were monitored at the site for 30min following vaccination and a telephonic survey was made till 7 days to identify all AEFIs. Causality assessments of the AEFIs were done using a new algorithm developed by the safety and vigilance department of the World Health Organization (WHO). Results: The incidence of reported AEFIs was 11.4% The most frequently reported AEFI within 1st 30minutes was vomiting [33%] and after 30 minutes waspain at injection site (n=26) with an incidence of 20.4% of vaccine administered, followed by fever (n=25, 19.6% of vaccine), headache (n=21) and giddiness (n=23 of vaccine). Consistent causal association to vaccination was observed in 93.4% of cases. Conclusions: AEFIs observed among Health Care Workers (HCWs) were non-serious. Hence, inactivated COVID vaccine used in the Vaccine program were found to be safe. Similarly, active multi-centric studies will help to generate more safety data about the inactivated COVID vaccine. Understanding vaccine safety issues among HCWs provide feedback to concerns of vaccine safety, which will enable them to communicate effectively with the public to maintain their confidence/trust in vaccines.