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419 results on '"Nagata, Yasuhiro"'

6. Prognostic significance of NY-ESO-1 antigen and PIGR expression in esophageal tumors of CHP-NY-ESO-1-vaccinated patients as adjuvant therapy

Author

Nagata, Yasuhiro, Kageyama, Shinichi, Ishikawa, Takeshi, Kokura, Satoshi, Okayama, Tetsuya, Abe, Tetsuya, Murakami, Masahiko, Otsuka, Koji, Ariyoshi, Tomotake, Kojima, Takashi, Taniguchi, Ken, Kobayashi, Shinichiro, Shimada, Hideaki, Yajima, Satoshi, Suzuki, Takashi, Hirano, Satoshi, Tsuchikawa, Takahiro, Shichinohe, Toshiaki, Ueda, Shugo, Kanetaka, Kengo, Yoneda, Akira, Wada, Hisashi, Doki, Yuichiro, Yamaue, Hiroki, Katsuda, Masahiro, Ohi, Masaki, Yasuda, Hiromi, Kondo, Ken, Kataoka, Masato, Kodera, Yasuhiro, Koike, Masahiko, Shiraishi, Taizo, Miyahara, Yoshihiro, Goshima, Naoki, Fukuda, Eriko, Yamaguchi, Kei, Sato, Eiichi, Ikeda, Hiroaki, Yamada, Tomomi, Osako, Masaharu, Hirai, Kaoru, Miyamoto, Hiroshi, Watanabe, Takashi, and Shiku, Hiroshi

Published
2022
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10. Feeling of incomplete bladder emptying and angiogenesis‐related polymorphism rs3025020 among older community‐dwelling individuals.

Author

Shimizu, Yuji, Kawashiri, Shin‐Ya, Noguchi, Yuko, Sasaki, Nagisa, Nakamichi, Seiko, Arima, Kazuhiko, Nagata, Yasuhiro, and Maeda, Takahiro

Subjects
VASCULAR endothelial growth factors, RISK assessment, CROSS-sectional method, INDEPENDENT living, RESEARCH funding, DESCRIPTIVE statistics, GENETIC polymorphisms, ODDS ratio, RETENTION of urine, PATHOLOGIC neovascularization, CONFIDENCE intervals, DISEASE progression, DISEASE risk factors, SYMPTOMS, OLD age
Abstract

Aim: To clarify the association between genetic factors related to angiogenesis and feeling of incomplete bladder emptying among older community‐dwelling individuals. Method: A cross‐sectional study of 1762 (607 men and 1155 women) older Japanese individuals aged 60–79 years with data on rs3025020 was conducted, because vascular endothelial growth factor (VEGF), which contributes to the progression of angiogenesis, has been reported to be positively associated with the minor allele (T) of polymorphism rs3025020. Results: In the study population, 155 (103 men and 52 women) had feeling of incomplete bladder emptying. With rs3025020 (C/C) as the reference group, rs3025020 (T/T) was associated with a significantly higher odds ratio (OR) for feeling of incomplete bladder emptying. The adjusted ORs and 95% confidence intervals were 3.01(1.53, 5.93) in men and 2.48 (1.09, 5.66) in women, respectively. Conclusion: VEGF polymorphism rs3025020 was associated with feeling of incomplete bladder emptying among older community‐dwelling individuals. Development of angiogenesis could be associated with feeling of incomplete bladder emptying in older individuals. Geriatr Gerontol Int 2024; 24: 1039–1044. [ABSTRACT FROM AUTHOR]

Published
2024
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11. O16-2 Phase I trial of NY-ESO-1 TCR-T cell therapy combined with nanoparticulate vaccine but without lymphodepletion for STS

Author

Ishihara, Mikiya, primary, Nishida, Yoshihiro, additional, Kitano, Shigehisa, additional, Kawai, Akira, additional, Harada, Naozumi, additional, Miyahara, Yoshihiro, additional, Hattori, Hiroyoshi, additional, Takada, Kohichi, additional, Emori, Makoto, additional, Kakunaga, Shigeki, additional, Endo, Makoto, additional, Matsumoto, Yoshihiro, additional, Sasada, Tetsuro, additional, Sato, Eiichi, additional, Yamada, Tomomi, additional, Matsumine, Akihiko, additional, Nagata, Yasuhiro, additional, Kageyama, Shinichi, additional, and Shiku, Hiroshi, additional

Published
2023
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21. Association between mental health and bone mass among community-dwelling adults: Nagasaki Islands Study on bone health

Author

Okawachi, Tetsuji, Arima, Kazuhiko, Mizukami, Satoshi, Koto, Serina, Suiko, Masahiro, Kit, Ayano, Nakashima, Hiroki, Uchiyama, Michiko, Honda, Yuzo, Tanaka, Natsumi, Tsujimoto, Ritsu, Nishimura, Takayuki, Tomita, Yoshihito, Abe, Yasuyo, Kusano, Yosuke, Kawashiri, Shin-Ya, Tamai, Mami, Yamanashi, Hirotomo, Nagata, Yasuhiro, Kawakami, Atsushi, Maeda, Takahiro, and Aoyagi, Kiyoshi

Subjects
Bone ultrasound, Kessler Psychological Distress Scale, community-dwelling adults, osteoporosis, human association studies
Abstract

Osteoporosis and its related fractures are important public health issues. This study examined the association between the Kessler Psychological Distress Scale (K6) and low bone mass in middle-aged community-dwelling men and women. A crosssectional study was nested in a prospective observational study of 1,101 participants (median age: 57 [49-62] years in men and 58 [50-62] years in women) residing in a rural city in western Japan. Participants were recruited during medical check-ups in 2016 and 2017 from the community-dwelling population. The bone mass of the calcaneus was evaluated using quantitative ultrasound. Of the participants, 56 men (14.9%) and 144 women (19.9%) had a bone mass of less than 70% of the mean of young adults. Univariate analysis revealed that there was a trend toward lower body mass index (BMI) and higher prevalence of low bone mass with an increase in K6 scores in men but not in women. Logistic regression analysis, adjusting for possible confounders (age, BMI, smoking, drinking habits, exercise habits, diabetes, hyperlipidemia, and hypertension), showed significant associations between the K6 scores and low bone mass (odds ratio (OR) = 2.66 for the men with 5 to 12 points of K6, OR = 7.51 for men with ≥ 13 of K6, not for women). We showed an association between psychological distress and low bone mass independent of cofounders among community-dwelling middle-aged men but not women. This suggests that healthy mental health in middle-aged men may be a possible target for the prevention of consequent osteoporosis or fragile bone fractures., Acta medica Nagasakiensia, 66(2), pp.81-86; 2023

Published
2023

23. Association between self-reported walking speed and calcaneal stiffness index in postmenopausal Japanese women

Author

Tomita, Yoshihito, Arima, Kazuhiko, Mizukami, Satoshi, Tsujimoto, Ritsu, Kawashiri, Shin-ya, Nishimura, Takayuki, Okabe, Takuhiro, Tanaka, Natsumi, Honda, Yuzo, Nakahara, Kazumi, Yamamoto, Naoko, Ohmachi, Izumi, Goto, Hisashi, Hasegawa, Maiko, Sou, Youko, Horiguchi, Itsuko, Kanagae, Mitsuo, Abe, Yasuyo, Nonaka, Fumiaki, Tamai, Mami, Yamanashi, Hirotomo, Nagata, Yasuhiro, Kawakami, Atsushi, Maeda, Takahiro, and Aoyagi, Kiyoshi

Published
2020
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37. A phase 1 trial of NY‐ESO ‐1‐specific TCR ‐engineered T‐cell therapy combined with a lymph node‐targeting nanoparticulate peptide vaccine for the treatment of advanced soft tissue sarcoma

Author

Ishihara, Mikiya, primary, Nishida, Yoshihiro, additional, Kitano, Shigehisa, additional, Kawai, Akira, additional, Muraoka, Daisuke, additional, Momose, Fumiyasu, additional, Harada, Naozumi, additional, Miyahara, Yoshihiro, additional, Seo, Naohiro, additional, Hattori, Hiroyoshi, additional, Takada, Kohichi, additional, Emori, Makoto, additional, Kakunaga, Shigeki, additional, Endo, Makoto, additional, Matsumoto, Yoshihiro, additional, Sasada, Tetsuro, additional, Sato, Eiichi, additional, Yamada, Tomomi, additional, Matsumine, Akihiko, additional, Nagata, Yasuhiro, additional, Watanabe, Takashi, additional, Kageyama, Shinichi, additional, and Shiku, Hiroshi, additional

Published
2023
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38. Serum Concentration of Growth Differentiation Factor 15 and Atherosclerosis among General Older Japanese Individuals with Normal Weight

Author

Shimizu, Yuji, Hayashida, Naomi, Yamanashi, Hirotomo, Noguchi, Yuko, Kawashiri, Shin-Ya, Takada, Midori, Arima, Kazuhiko, Nakamichi, Seiko, Nagata, Yasuhiro, Maeda, Takahiro, Shimizu, Yuji, Hayashida, Naomi, Yamanashi, Hirotomo, Noguchi, Yuko, Kawashiri, Shin-Ya, Takada, Midori, Arima, Kazuhiko, Nakamichi, Seiko, Nagata, Yasuhiro, and Maeda, Takahiro

Abstract

Biomedicines, 11(6), art. no. 1572; 2023

Published
2023

39. Association of FTO genotype with obesity and bone health among communitydwelling adults ; Goto Island study on bone health

Author

Xiao, Xu, Mizukami, Satoshi, Arima, Kazuhiko, Morikawa, Kyoya, Motoi, Midori, Iwamoto, Naoki, Tomita, Yoshihito, Uchiyama, Michiko, Honda, Yuzo, Tanaka, Natsumi, Goto, Hisashi, Hasegawa, Maiko, Sou, Youko, Tsujimoto, Ritsu, Nishimura, Takayuki, Kawashiri, Shin-ya, Tamai, Mami, Yamanashi, Hirotomo, Abe, Yasuyo, Origuchi, Tomoki, Nagata, Yasuhiro, Kawakami, Atsushi, Maeda, Takahiro, and Aoyagi, Kiyoshi

Subjects
Bone ultrasound, Human association studies, General population studies, Osteoporosis, FTO gene
Abstract

Bone mass is tuned by various factors, including aging, menopause, low body weight, and genetic variations. Here, we showed an independent association between a genotype on the fat mass- and obesity-associated FTO gene (#610966 on OMIM) and bone loss after adjusting for age and body mass index (BMI). A cross-sectional study was nested in a prospective observational study of 1,828 participants (median age: 69 [62-76] years in men and 68 [61-75] years in women) residing in a rural city in western Japan (Goto Island study). Participants were recruited during medical checkups in 2014 and 2016 from the community-dwelling population. The bone mass of the calcaneus was evaluated using quantitative ultrasound. The single nucleotide polymorphism (SNP) rs1421085 was genotyped using a hydrolysis probe. The chi-squared test was used to determine whether the variants were in equilibrium in this population. There were differences in medians of BMI among the genotypes (24.3 in CC, 23.0 in CT, and 22.6 in TT, P = 0.01), but not in those of bone mass. There was a significant association between the minor allele (C) and being overweight in a gene dosage-dependent manner (BMI > 25, OR per allele =1.52, 95% CI = 1.07-2.14, P = 0.02 in men, OR = 1.48, 95% CI = 1.16-1.95, P = 0.01 in women). Logistic regression analysis showed a significant protective association in male carriers of the minor allele against low bone mass (QUS T-score less than -2.0) after adjusting for age and BMI in men aged 65-75 years (OR = 0.50, 95% CI = 0.27-0.96, P = 0.036), with no significant association in women.Our study indicated an association between the genetic polymorphism of FTO and bone mass among community-dwelling men aged 65-75 years. The polymorphism may play a role in bone health with higher BMI and other beneficial functions., Acta medica Nagasakiensia, 65(3), pp.77-87; 2022

Published
2022

43. Subclinical hypothyroidism and hypertension in relation to thyroid cysts: A cross-sectional study

Author

Ozasa, Souichiroh, Kawashiri, Shin-Ya, Noguchi, Yuko, Nagata, Yasuhiro, Maeda, Takahiro, Hayashida, Naomi, and Shimizu, Yuji

Subjects
endocrine system, thyroid cyst, endocrine system diseases, thyroid-stimulating hormone, thyroid hormone, subclinical hypothyroidism
Abstract

Subclinical hypothyroidism is a condition characterized by a normal range of thyroid hormone [triiodothyronine (T 3) and thyroxine (T 4)] but with an elevated level of thyroid stimulating hormone (TSH) . It is also reported to be associated with hypertension. Since thyroid cysts could have a beneficial effect on the activation of thyroid hormone as reported in our previous study, their presence could influence the association between subclinical hypothyroidism and hypertension. To clarify those associations, a cross-sectional study of 1,724 Japanese within normal range of thyroid hormone (i.e., normal range of free T 3 and free T 4), aged 40-74 years, who participated in an annual health checkup in 2014 was conducted. Among the study population, 98 were diagnosed as having sublicnical hypothyroidism. For participants without a thyroid cyst, hypertension had a significant positive association with subclinical hypothyroidism, while for participants with a thyroid cyst, even though the power could not reach a significant value, an inverse tendency between hypertension and subclinical hypothyroidism was observed. The adjusted odd ratios (ORs) and 95% confidence intervals (CIs) were 1.91 (1.08, 3.37) for participants without thyroid cysts and 0.63 (0.26, 1.55) for participants with thyroid cysts, respectively. The status of thyroid cysts could act as a determining factor in the association between subclinical hypothyroidism and hypertension among participants within normal range of thyroid hormone., Acta medica Nagasakiensia, 65(2), pp.57−62; 2022

Published
2022

46. Chimeric antigen receptor T-cell therapy targeting a MAGE A4 peptide and HLA-A*02:01 complex for unresectable advanced or recurrent solid cancer: protocol for a multi-institutional phase 1 clinical trial

Author

Okumura, Satoshi, primary, Ishihara, Mikiya, additional, Kiyota, Naomi, additional, Yakushijin, Kimikazu, additional, Takada, Kohichi, additional, Kobayashi, Shinichiro, additional, Ikeda, Hiroaki, additional, Endo, Makoto, additional, Kato, Koji, additional, Kitano, Shigehisa, additional, Matsumine, Akihiko, additional, Nagata, Yasuhiro, additional, Kageyama, Shinichi, additional, Shiraishi, Taizo, additional, Yamada, Tomomi, additional, Horibe, Keizo, additional, Takesako, Kazuto, additional, Miwa, Hiroshi, additional, Watanabe, Takashi, additional, Miyahara, Yoshihiro, additional, and Shiku, Hiroshi, additional

Published
2022
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