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44 results on '"Nagatomo, Itsugi"'

41. Influences of caffeine to nitric oxide production and zonisamide concentration in the brain of seizure-susceptible EL mice.

Author

Nagatomo, Itsugi, Hashiguchi, Wataru, Akasaki, Yasuaki, Uchida, Masahiro, Tominaga, Masataka, and Takigawa, Morikuni

Subjects
*NITRIC oxide, *MICE, *PHYSIOLOGICAL effects of caffeine, *SCIENTIFIC experimentation
Abstract

Abstract To investigate changes of nitric oxide (NO) productions and zonisamide (ZNS) concentrations in the brain of seizure-susceptible EL mice given caffeine orally, mice were given caffeine (600 μg/mL) solution ad libitum as a drinking fluid for 1–3 weeks. Nitric oxide production in the brain was determined by measuring levels of nitrite plus nitrate (NOx). The brain NOx levels of mice treated with caffeine for 3 weeks were significantly higher than the control. Seizures in mice treated with caffeine for 2 and 3 weeks were not suppressed by ZNS at a dose of 75 mg/kg. Serum ZNS concentrations of mice with caffeine intake for 1–3 weeks were higher than in untreated mice. Conversely, brain ZNS concentrations of mice with caffeine intake for the same periods were significantly lower than in untreated mice. These results suggested that caffeine influenced brain NO production and ZNS concentrations in the seizure susceptibility of EL mice. [ABSTRACT FROM AUTHOR]

Published
2001
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42. Alterations of nitric oxide and monoamines in the brain of the EL mouse treated with phenobarbital and zonisamide.

Author

Nagatomo, Itsugi, Tominaga, Masataka, Uchida, Masahiro, Hashiguchi, Wataru, Akasaki, Yasuaki, and Takigawa, Morikuni

Subjects
*MICE, *NITRIC oxide, *ANTICONVULSANTS, *SEIZURES (Medicine), *SCIENTIFIC experimentation
Abstract

Abstract The effects of phenobarbital (PB; doses, 5, 10, and 25 mg/kg, intraperitoneally (i.p.)) and zonisamide (ZNS; doses, 30, 75, and 150 mg/kg, i.p.) on nitric oxide (NO) production, and those of coadministration of PB (5 mg/kg, i.p.) and ZNS (75 mg/kg, i.p.) on monoamines in the brain of the seizure-susceptible EL mouse were investigated. Nitric oxide production was obtained by measuring the combined level of nitrite plus nitrate (NOx). Zonisamide and PB dose-dependently suppressed the seizure of the EL mouse, and coadministration of PB (5 mg/kg) and ZNS (75 mg/kg) induced a greater degree of seizure suppression than treatment with ZNS or PB alone. Although PB (5 mg/kg) had no effect on brain NOx levels, ZNS (150 mg/kg) and coadministration of ZNS (75 mg/kg) and PB (5 mg/kg) decreased NOx levels significantly. Phenobarbital (5 mg/kg) did not influence monoamines, while coadministration of PB (5 mg/kg) and ZNS (75 mg/kg) decreased dihydroxyphenylacetic acid and increased 5-HT concentrations. The effect of the coadministration of two drugs on monoamines were similar to that of ZNS alone. These results suggest that one of the anticonvulsant effects of coadministration of PB and ZNS may be caused by changes in NOx levels. [ABSTRACT FROM AUTHOR]

Published
2001
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43. BLOOD FLOW VELOCITY WAVEFORM IN THE COMMON CAROTID ARTERY IN ADVANCED AGE AND CLINICAL OUTCOME--A 1-YEAR FOLLOW-UP.

Author

Nagatomo, Itsugi, Nomaguchi, Mitsuo, and Matsumoto, Kei

Subjects
*DISEASES in older people, *BLOOD flow, *CAROTID artery, *HEALTH of older people, *MORTALITY, *GERIATRICS
Abstract

We investigated the common carotid arterial blood blow in 70 patients of advanced age (80 and older) in a nursing home using an ultrasonic quantitative blood flow measurement system. Systolic and end-diastolic velocities were obtained from the waveform, and using these two velocities, subjects were classified into three groups according to increasing severity. We then determined mortality rates and changes in the modified Stockton Geriatric Rating Scale (SGRS) over a 1-year period. The mortality of group 1 was significantly lower than that of group 3. the groups with more severely impaired carotid blood flow also demonstrated as groups change in the sequence 1→2→3 a worsening on some subscales of the modified SGRS over the year. These results suggest that carotid arterial blood flow velocity waveform can serve to predict some aspects of clinical outcome in very old age. [ABSTRACT FROM AUTHOR]

Published
1993
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