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Your search keyword '"Naidu, B. N."' showing total 30 results
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30 results on '"Naidu, B. N."'

1. Digit ratio and its implications on exercise capacity among non-athlete Indian male subjects

Author

Naidu B N A M, Arjun Maitra, Vinita Ailani, and Nitin Srivastava

Subjects
medicine.medical_specialty, Digit ratio, Physiology, business.industry, medicine.drug_class, medicine.disease, Androgen, Metabolic equivalent, Correlation, Bruce protocol, Internal medicine, Cardiology, Medicine, Myocardial infarction, General Pharmacology, Toxicology and Pharmaceutics, Treadmill, business, Aerobic capacity
Abstract

Background: The index (2D)-to-ring (4D) finger length ratio (2D:4D) commonly known as digit ratio has been the subject of recent interest and is thought to be related to sports ability, endurance running, disease susceptibility, and myocardial infarction at early age. Sexually dimorphic digit ratio is widely accepted as a putative marker for prenatal androgen exposure with men tends to have smaller ratio. Aim and Objective: The present study was conducted to evaluate any relation between digit ratio and exercise capacity in non-athlete Indian males. Materials and Methods: The study was conducted in the Department of Physiology of Mayo Institute of Medical Sciences, Barabanki, with 50 clinically normal healthy male volunteers. Finger lengths were measured directly using digital Vernier calipers. Exercise tolerance testing was done as per Bruce protocol with Allengers Gemini A-DX treadmill. Results: Two groups of higher (n = 26) and lower (n = 24) finger length ratio (right hand) were formed using median split. Significant difference observed (P = 0.0012, P < 0.05) for exercise capacity or percentage of predicated metabolic equivalents (METs) achieved having higher percentage by the low finger length ratio group. No significant difference observed for METs achieved for the groups. Correlation study shows a significant moderate negative correlation between digit ratio (right) and exercise capacity. Similar correlation was not significant for the left hand. Conclusion: These results suggest that a low digit ratio (right hand) is related to better aerobic capacity and exercise capacity in the males although the exact role of prenatal androgen exposure is unclear.

Published
2021
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2. Fatehgarh lacustrine turbidite potential, Barmer Basin, India

Author

Chatterjee, Priyabrata, primary, Kuila, Utpalendu, additional, Naidu, B. N. S., additional, Bora, Hriday Jyoti, additional, Malkani, Anil, additional, Dutta, Sandipan, additional, Mandal, Arpita, additional, Mishra, Premanand, additional, and Mohapatra, Pinakadhar, additional

Published
2019
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20. Stereoselective formation and rearrangement of morpholinium ylides derived from copper carbenoids

Author

Glaeske, Kevin W., Naidu, B. N., and West, F. G.

Subjects
*ACETATES, *CARBENES
Abstract

Amino diazoacetoacetates 4a–e and 7a,b were prepared from readily available amino alcohols and subjected to copper-catalyzed carbene-transfer reaction. Substrates 4c–e furnished the morpholin-2-ones 5c–e in good yield via the corresponding cyclic ammonium ylides, albeit with poor diastereoselectivity. Substrates 4a,b failed to provide the corresponding morpholinones, perhaps as a result of steric congestion. Cyclic substrates 7a,b underwent conversion to bicyclic morpholinones 8 and 9 in good yield and with moderate to good diastereoselectivity. This result is rationalized via control of the transiently stereogenic ammonium center of the intermediate bicyclic ylides. [Copyright &y& Elsevier]

Published
2003
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21. Developments in Antiviral Drug Design, Discovery and Development in 2004

Author

Meanwell, Nicholas A., Belema, Makonen, Carini, David J., D'Andrea, Stanley V., Kadow, John F., Krystal, Mark, Naidu, B. N., Regueiro-Ren, Alicia, Scola, Paul M., Sit, Sing-Yuen, Walker, Michael A., Wang, Tao, and Yeung, Kap-Sun

Abstract

This article summarizes key aspects of progress made during 2004 toward the design, discovery and development of antiviral agents for clinical use. Important developments in the identification, characterization and clinical utility of inhibitors of human immunodeficiency virus; the hepatitis viruses, hepatitis B, hepatitis C; the herpes family of viruses, herpes simplex viruses 1 and 2, varicella zoster virus, Epstein-Barr virus and human cytomegalovirus; the respiratory viruses, influenza, respiratory syncytial virus, human metapneumovirus, picornaviruses, measles and the severe acute respiratory syndrome coronavirus; human papilloma virus; rotavirus; Ebola virus and West Nile virus, are reviewed.

Published
2005

22. Discovery of a Fluoroindolo[2,3-a]carbazole Clinical Candidate with Broad Spectrum Antitumor Activity in Preclinical Tumor Models Superior to the Marketed Oncology Drug, CPT-11

Author

Saulnier, M. G., Balasubramanian, B. N., Long, B. H., Frennesson, D. B., Ruediger, E., Zimmermann, K., Eummer, J. T., Laurent, D. R. St., Stoffan, K. M., Naidu, B. N., Mahler, M., Beaulieu, F., Bachand, C., Lee, F. Y., Fairchild, C. R., Stadnick, L. K., Rose, W. C., Solomon, C., Wong, H., Martel, A., Wright, J. J., Kramer, R., Langley, D. R., and Vyas, D. M.

Abstract

A series of fluoroglycosylated fluoroindolocarbazoles was examined with respect to their topoisomerase I activity, cytotoxicity, and selectivity. The lead clinical candidate from this series, BMS-250749, displays broad spectrum antitumor activity superior to CPT-11 against some preclinical xenograft models, including curative antitumor activity against Lewis lung carcinoma.

Published
2005

23. Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β- <SCP>d</SCP>-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6H)-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model

Author

Balasubramanian, B. N., Laurent, D. R. St., Long, B. H., Bachand, C., Beaulieu, F., Clarke, W., Deshpande, M., Eummer, J., Fairchild, C. R., Frennesson, D. B., Kramer, R., Lee, F. Y., Mahler, M., Martel, A., Naidu, B. N., Rose, W. C., Russell, J., Ruediger, E., Saulnier, M. G., Solomon, C., Stoffan, K. M., Wong, H., Zimmermann, K., and Vyas, D. M.

Abstract

A series of fluoroindolocarbazoles were studied with respect to their topoisomerase I activity, cytotoxicity, selectivity, and in vivo antitumor activity. Emerging from this series was BMS-251873, a potential clinical candidate possessing a robust pharmacological profile including curative antitumor activity against prostate carcinoma.

Published
2004

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