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3. A Dose-Finding Study to Guide Use of Verapamil as an Adjunctive Therapy in Tuberculosis.

Author

Padmapriyadarsini, Chandrasekaran, Szumowski, John, Akbar, Nabila, Shanmugasundaram, Prema, Jain, Anilkumar, Bathragiri, Marasamy, Pattnaik, Manoranjan, Turuk, Jyotirmayee, Karunaianantham, Ramesh, Balakrishnan, Senthilkumar, Pati, Sanghamitra, Kumar, A, Rathore, Manoj, Raja, Jegadeesh, Naidu, K, Horn, John, Whitworth, Laura, Sewell, Roger, Ramakrishnan, Lalita, Swaminathan, Soumya, and Edelstein, Paul

Subjects
Humans, Antitubercular Agents, Mycobacterium tuberculosis, Rifampin, Tuberculosis, Verapamil
Abstract

Induction of mycobacterial efflux pumps is a cause of Mycobacterium tuberculosis (Mtb) drug tolerance, a barrier to shortening antitubercular treatment. Verapamil inhibits Mtb efflux pumps that mediate tolerance to rifampin, a cornerstone of tuberculosis (TB) treatment. Verapamils mycobacterial efflux pump inhibition also limits Mtb growth in macrophages in the absence of antibiotic treatment. These findings suggest that verapamil could be used as an adjunctive therapy for TB treatment shortening. However, verapamil is rapidly and substantially metabolized when co-administered with rifampin. We determined in a dose-escalation clinical trial of persons with pulmonary TB that rifampin-induced clearance of verapamil can be countered without toxicity by the administration of larger than usual doses of verapamil. An oral dosage of 360 mg sustained-release (SR) verapamil given every 12 hours concomitantly with rifampin achieved median verapamil exposures of 903.1 ng.h/mL (area under the curve (AUC)0-12 h ) in the 18 participants receiving this highest studied verapamil dose; these AUC findings are similar to those in persons receiving daily doses of 240 mg verapamil SR but not rifampin. Moreover, norverapamil:verapamil, R:S verapamil, and R:S norverapamil AUC ratios were all significantly greater than those of historical controls receiving SR verapamil in the absence of rifampin. Thus, rifampin administration favors the less-cardioactive verapamil metabolites and enantiomers that retain similar Mtb efflux inhibitory activity to verapamil, increasing overall benefit. Finally, rifampin exposures were 50% greater after verapamil administration, which may also be advantageous. Our findings suggest that a higher dosage of verapamil can be safely used as adjunctive treatment in rifampin-containing treatment regimens.

Published
2024

25. Frequency Control of Wind Integrated Isolated Power System with I-PD Controller

Author

Appala Naidu, K., Shaw, Binod, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Namrata, Kumari, editor, Priyadarshi, Neeraj, editor, Bansal, Ramesh C., editor, and Kumar, Jitendra, editor

Published
2023
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43. Water-borne Polyurethane-Metal Oxide Nanocomposite Applications

Author

Banerjee, Prasun, Franco, Adolfo, Chandra Babu Naidu, K., Suresh Kumar, N., Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Inamuddin, editor, Boddula, Rajender, editor, and Khan, Anish, editor

Published
2021
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44. Electrochemical Green Synthesis

Author

Suresh Kumar, N., Padma Suvarna, R., Chandra Babu Naidu, K., Manjunatha, H., Ratnamala, A., Ajay Kumar, M., Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Inamuddin, editor, Boddula, Rajender, editor, Ahamed, Mohd Imran, editor, and Khan, Anish, editor

Published
2021
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46. Experimental Investigation of Aerodynamic Coefficients of NACA 4412 Aerofoil

Author

Sharma, Vikas, Dutta, Sushanta, Shashi Kumar Naidu, K., Ajay Kumar, M., Cavas-Martínez, Francisco, Series Editor, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Haddar, Mohamed, Series Editor, Ivanov, Vitalii, Series Editor, Kwon, Young W., Series Editor, Trojanowska, Justyna, Series Editor, di Mare, Francesca, Series Editor, Prabu, T., editor, Viswanathan, P., editor, Agrawal, Amit, editor, and Banerjee, Jyotirmay, editor

Published
2021
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47. The Characteristics of Heat and Mass Transfer on MHD Fluid Flow over a Moving Melting Surface

Author

Harinath Reddy, S., Harish Babu, D., Kumaraswamy Naidu, K., Raju, M. C., Satya Narayana, P. V., Chaari, Fakher, Series Editor, Haddar, Mohamed, Series Editor, Kwon, Young W., Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Trojanowska, Justyna, Series Editor, Rushi Kumar, B., editor, Sivaraj, R., editor, and Prakash, J., editor

Published
2021
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48. A Machine Learning Approach for Air Pollution Analysis

Author

Lalitha, R. V. S., Kavitha, Kayiram, Vijaya Durga, Y., Sowbhagya Naidu, K., Uma Manasa, S., Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Bhattacharyya, Siddhartha, editor, Nayak, Janmenjoy, editor, Prakash, Kolla Bhanu, editor, Naik, Bighnaraj, editor, and Abraham, Ajith, editor

Published
2021
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49. Phase Change Materials for Thermal Energy Storage: A Concise Review.

Author

Prasad, N. V. Krishna, Naidu, K. Chandra Babu, and Basha, D. Baba

Subjects
*HEAT storage, *PHASE change materials, *ENERGY storage, *THERMAL conductivity, *PHASE transitions, *LATENT heat, *HEAT capacity
Abstract

Thermal energy and its storage systems play an extensive role in day-to-day life. They store renewable energy and are capable of recovering generated heat from different systems. Storage of thermal energy can be classified into three types: sensible, latent and sorption heat storages. Thermal heat storages use different types of materials based on their capacity of heat storage, stability of duration and thermal conductivity. Various phase change materials (PCMs) that are suitable for thermal storage are reported. Low conversion ability limits their effectiveness. We reviewed some of the traditional materials synthesized recently that are used for thermal energy storage (TES). Recently developed TES materials exhibit high thermal conductivity, reduced super cooling and multiple phase change temperatures. Nano-enhanced PCMs produced an increase in thermal conductivity up to 32% with a reduction in latent heat by 32%. At this juncture, MXenes with high performance and extraordinary properties (thermal, mechanical, etc.) are of special significance. MXenes displayed an increased thermal conductivity up to 16% and 94% efficiency. In view of their structure and adaptability to be used in thermal storage systems, an attempt was made to review their role also in thermal storage applications. It is observed that MXenes highly impact storage and efficiency. Apart from MXenes, various types of PCMs along with their thermal characteristics are presented. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Structural, optical and multiferroic properties of (1-x)BiFeO3-xNa0.5Bi0.5TiO3, x = 0.00, 0.05, 0.10 and 0.15.

Author

Sudhadhar, M., Rao, T. Durga, Lakshmi, Ch. Komala, Bhavani, G., Pal, B. Munendra, Sattibabu, B., Naidu, K. Lakshun, Bharadwaj, S., Sudharshan, V., Karthik, T., and Asthana, Saket

Subjects
ELECTRIC measurements, DIELECTRIC measurements, OPTICAL properties, MAGNETIC anomalies, X-ray diffraction measurement
Abstract

The polycrystalline (1-x)BiFeO3-xNa0.5Bi0.5TiO3, x = 0.00, 0.05, 0.10 and 0.15, ceramics were prepared using conventional solid-state route. The structural studies using X-ray diffraction and Raman measurements confirmed the rhombohedral R3c structure of the compounds. The scanning electron micrographs showed that grain size decreased, and the density of the compounds increased with the higher Na0.5Bi0.5TiO3 content. The weak ferromagnetism was induced in the solid solution of antiferromagnetic BiFeO3 compound with Na0.5Bi0.5TiO3 content. The structural distortions were increased with the increase of x, which favours the increase of weak ferromagnetism in the antiferromagnetic compound. The electric polarisation measurements indicated that leakage character decreased with the increase in Na0.5Bi0.5TiO3 fraction. The temperature and frequency-dependent dielectric measurements showed that the dielectric constant was improved and loss tangent was decreased in Na0.5Bi0.5TiO3 rich compounds. The temperature dependence of dielectric constant data showed a dielectric anomaly near the magnetic transition of BiFeO3, which shifted towards the lower temperature side with the increase of x. The UV-VIS-NIR spectroscopy measurements evidenced an increase in band gap energy for higher Na0.5Bi0.5TiO3 concentration.. [ABSTRACT FROM AUTHOR]

Published
2024
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