Search

Your search keyword '"Naik, Marcel"' showing total 156 results
Start Over Author "Naik, Marcel"
156 results on '"Naik, Marcel"'

1. This Patient Looks Like That Patient: Prototypical Networks for Interpretable Diagnosis Prediction from Clinical Text

Author

van Aken, Betty, Papaioannou, Jens-Michalis, Naik, Marcel G., Eleftheriadis, Georgios, Nejdl, Wolfgang, Gers, Felix A., and Löser, Alexander

Subjects
Computer Science - Computation and Language
Abstract

The use of deep neural models for diagnosis prediction from clinical text has shown promising results. However, in clinical practice such models must not only be accurate, but provide doctors with interpretable and helpful results. We introduce ProtoPatient, a novel method based on prototypical networks and label-wise attention with both of these abilities. ProtoPatient makes predictions based on parts of the text that are similar to prototypical patients - providing justifications that doctors understand. We evaluate the model on two publicly available clinical datasets and show that it outperforms existing baselines. Quantitative and qualitative evaluations with medical doctors further demonstrate that the model provides valuable explanations for clinical decision support., Comment: AACL-IJCNLP 2022 Main Conference (Long Paper)

Published
2022

2. A Medical Information Extraction Workbench to Process German Clinical Text

Author

Roller, Roland, Seiffe, Laura, Ayach, Ammer, Möller, Sebastian, Marten, Oliver, Mikhailov, Michael, Alt, Christoph, Schmidt, Danilo, Halleck, Fabian, Naik, Marcel, Duettmann, Wiebke, and Budde, Klemens

Subjects
Computer Science - Computation and Language
Abstract

Background: In the information extraction and natural language processing domain, accessible datasets are crucial to reproduce and compare results. Publicly available implementations and tools can serve as benchmark and facilitate the development of more complex applications. However, in the context of clinical text processing the number of accessible datasets is scarce -- and so is the number of existing tools. One of the main reasons is the sensitivity of the data. This problem is even more evident for non-English languages. Approach: In order to address this situation, we introduce a workbench: a collection of German clinical text processing models. The models are trained on a de-identified corpus of German nephrology reports. Result: The presented models provide promising results on in-domain data. Moreover, we show that our models can be also successfully applied to other biomedical text in German. Our workbench is made publicly available so it can be used out of the box, as a benchmark or transferred to related problems., Comment: Paper under review since 2021

Published
2022

3. Novel approaches to sarcopenic obesity and weight management before and after kidney transplantation.

Author

Tantisattamo, Ekamol, Kalantar-Zadeh, Kamyar, Halleck, Fabian, Duettmann, Wiebke, Naik, Marcel, and Budde, Klemens

Subjects
Humans, Kidney Failure, Chronic, Obesity, Weight Loss, Treatment Outcome, Exercise, Perioperative Care, Kidney Transplantation, Living Donors, Waiting Lists, Bariatric Surgery, Renal Insufficiency, Chronic, Muscle Strength, Sarcopenia, Nutrition, Transplantation, Clinical Research, Prevention, Organ Transplantation, Kidney Disease, Stroke, Cancer, Renal and urogenital, Cardiovascular, Oral and gastrointestinal, Metabolic and endocrine, Generic health relevance, epidemiology, kidney transplantation, obesity, obesity paradox, outcome, reverse epidemiology, sarcopenia, sarcopenic obesity, waitlist candidate, Clinical Sciences, Urology & Nephrology
Abstract

Purpose of reviewAlthough a widely recognized and complex pathophysiological condition, sarcopenic obesity remains less appreciated and may elude diagnosis and workup in both kidney transplant waitlisted candidates and kidney transplant recipients. The lack of consensus definition, and practical diagnostic tools for evaluating waitlisted candidates and transplant recipients are barriers to early detect and initiate therapeutic management for sarcopenic obesity. Although sarcopenia leads to poor clinical outcomes, posttransplant obesity yields conflicting results. Exercise and nutritional managements are common therapies for sarcopenic obese patients; however, surgery weight loss or bariatric surgery in both transplant candidates and potential living kidney donors shows promising benefits for kidney transplant access in waitlist obese candidates but may require to be selected for appropriate patients.Recent findingsPathogenesis and management for sarcopenia and obesity are interconnected. The benefits of exercise to improve muscle mass and function is clear in waitlist kidney transplant candidates and transplant recipients. However, there are several barriers for those to increase exercise and improve physical activity including patient, provider, and healthcare or environmental factors. The advantages of fat mass reduction to lose weight can promote muscle mass and strength. However, epidemiological data regarding the obesity paradox in dialysis-dependent patients when overnutrition provides survival benefits for this population should be taken into account when performing weight loss especially bariatric surgery.SummaryBarriers in providing optimal care to kidney transplant waitlisted candidates and transplant recipients may partly result from underdiagnosis of sarcopenic obesity; notwithstanding that this entity has increasingly been more recognized. Mechanistic studies to better understand pathogenesis of sarcopenic obesity will help determine pathogenesis and clinical tools for diagnosis of this entity, which can facilitate further studies related to the outcomes and weight management to ultimately improve kidney transplant outcomes.

Published
2021

4. Immunsuppression

Author

Budde, Klemens, Naik, Marcel, Rahmel, Axel, editor, Hahnenkamp, Klaus, editor, and Middel, Claus-Dieter, editor

Published
2022
Full Text
View/download PDF

6. #2933 Quality of care in patients after kidney transplantation with or without telemedicine

Author

Duettmann, Wiebke, primary, Pohl, Nathan Andreas, additional, Zukunft, Bianca, additional, Osmanodja, Bilgin, additional, Halleck, Fabian, additional, Naik, Marcel, additional, Eleftheriadis, Georgios, additional, Hansen, Carla Maria, additional, Choi, Mira, additional, Bachmann, Friederike, additional, Hoegl, Caroline, additional, and Budde, Klemens, additional

Published
2024
Full Text
View/download PDF

7. SGAIN, WSGAIN-CP and WSGAIN-GP: Novel GAN Methods for Missing Data Imputation

Author

Neves, Diogo Telmo, Naik, Marcel Ganesh, Proença, Alberto, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Paszynski, Maciej, editor, Kranzlmüller, Dieter, editor, Krzhizhanovskaya, Valeria V., editor, Dongarra, Jack J., editor, and Sloot, Peter M. A., editor

Published
2021
Full Text
View/download PDF

8. Office or home versus 24-hour blood pressure measurement in stable kidney transplant recipients

Author

Eleftheriadis, Georgios, primary, Naik, Marcel G, additional, Osmanodja, Bilgin, additional, Halleck, Fabian, additional, Schrezenmeier, Eva, additional, Liefeldt, Lutz, additional, Choi, Mira, additional, Bachmann, Friederike, additional, Avaniadi, Despina Parthenopi, additional, von Hoerschelmann, Ellen, additional, Lücht, Christian, additional, Zaks, Marina, additional, Duettmann, Wiebke, additional, and Budde, Klemens, additional

Published
2024
Full Text
View/download PDF

10. Letermovir Rescue Therapy in Kidney Transplant Recipients with Refractory/Resistant CMV Disease

Author

von Hoerschelmann, Ellen, primary, Münch, Johannes, additional, Gao, Linde, additional, Lücht, Christian, additional, Naik, Marcel G., additional, Schmidt, Danilo, additional, Pitzinger, Paul, additional, Michel, Detlef, additional, Avaniadi, Parthenopi, additional, Schrezenmeier, Eva, additional, Choi, Mira, additional, Halleck, Fabian, additional, and Budde, Klemens, additional

Published
2023
Full Text
View/download PDF

11. NephroCAGE—German-Canadian Consortium on AI for Improved Kidney Transplantation Outcome: Protocol for an Algorithm Development and Validation Study

Author

Schapranow, Matthieu-P, primary, Bayat, Mozhgan, additional, Rasheed, Aadil, additional, Naik, Marcel, additional, Graf, Verena, additional, Schmidt, Danilo, additional, Budde, Klemens, additional, Cardinal, Héloïse, additional, Sapir-Pichhadze, Ruth, additional, Fenninger, Franz, additional, Sherwood, Karen, additional, Keown, Paul, additional, Günther, Oliver P, additional, Pandl, Konstantin D, additional, Leiser, Florian, additional, Thiebes, Scott, additional, Sunyaev, Ali, additional, Niemann, Matthias, additional, Schimanski, Andreas, additional, and Klein, Thomas, additional

Published
2023
Full Text
View/download PDF

13. Plasma NGAL levels in stable kidney transplant recipients and the risk of allograft loss.

Author

Swolinsky, Jutta S, Hinz, Ricarda M, Markus, Carolin E, Singer, Eugenia, Bachmann, Friederike, Halleck, Fabian, Kron, Susanne, Naik, Marcel G, Schmidt, Danilo, Obermeier, Martin, Gebert, Pimrapat, Rauch, Geraldine, Kropf, Siegfried, Haase, Michael, Budde, Klemens, Eckardt, Kai-Uwe, Westhoff, Timm H, and Schmidt-Ott, Kai M

Subjects
KIDNEY transplantation, LIPOCALIN-2, HOMOGRAFTS, RECEIVER operating characteristic curves, CALPROTECTIN, DEAD
Abstract

Background The objective of this study was to investigate the utility of neutrophil gelatinase-associated lipocalin (NGAL) and calprotectin (CPT) to predict long-term graft survival in stable kidney transplant recipients (KTR). Methods A total of 709 stable outpatient KTR were enrolled >2 months post-transplant. The utility of plasma and urinary NGAL (pNGAL, uNGAL) and plasma and urinary CPT at enrollment to predict death-censored graft loss was evaluated during a 58-month follow-up. Results Among biomarkers, pNGAL showed the best predictive ability for graft loss and was the only biomarker with an area under the curve (AUC) > 0.7 for graft loss within 5 years. Patients with graft loss within 5 years (n  = 49) had a median pNGAL of 304 [interquartile range (IQR) 235–358] versus 182 (IQR 128–246) ng/mL with surviving grafts (P  < .001). Time-dependent receiver operating characteristic analyses at 58 months indicated an AUC for pNGAL of 0.795, serum creatinine–based Chronic Kidney Disease Epidemiology Collaboration estimated glomerular filtration rate (eGFR) had an AUC of 0.866. pNGAL added to a model based on conventional risk factors for graft loss with death as competing risk (age, transplant age, presence of donor-specific antibodies, presence of proteinuria, history of delayed graft function) had a strong independent association with graft loss {subdistribution hazard ratio (sHR) for binary log-transformed pNGAL [log2(pNGAL)] 3.4, 95% confidence interval (CI) 2.24–5.15, P  < .0001}. This association was substantially attenuated when eGFR was added to the model [sHR for log2(pNGAL) 1.63, 95% CI 0.92–2.88, P  = .095]. Category-free net reclassification improvement of a risk model including log2(pNGAL) in addition to conventional risk factors and eGFR was 54.3% (95% CI 9.2%–99.3%) but C-statistic did not improve significantly. Conclusions pNGAL was an independent predictor of renal allograft loss in stable KTR from one transplant center but did not show consistent added value when compared with baseline predictors including the conventional marker eGFR. Future studies in larger cohorts are warranted. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

14. Predictors of graft failure after first detection of de novo donor-specific HLA antibodies in kidney transplant recipients.

Author

Moral, Covadonga López del, Wu, Kaiyin, Naik, Marcel, Osmanodja, Bilgin, Akifova, Aylin, Lachmann, Nils, Stauch, Diana, Hergovits, Sabine, Choi, Mira, Bachmann, Friederike, Halleck, Fabian, Schrezenmeier, Eva, Schmidt, Danilo, and Budde, Klemens

Subjects
KIDNEY transplantation, RECEIVER operating characteristic curves, ASYMPTOMATIC patients, GRAFT rejection, GLOMERULAR filtration rate
Abstract

Background De novo donor-specific antibodies (dnDSAs) may cause antibody-mediated rejection and graft dysfunction. Little is known about the clinical course after first detection of dnDSAs during screening in asymptomatic patients. We aimed to assess the value of estimated glomerular filtration rate (eGFR) and proteinuria to predict graft failure in patients with dnDSAs and their potential utility as surrogate endpoints. Methods All 400 kidney transplant recipients with dnDSAs at our centre (1 March 2000–31 May 2021) were included in this retrospective study. The dates of graft loss, rejection, doubling of creatinine, ≥30% eGFR decline, proteinuria ≥500 mg/g and ≥1000 mg/g were registered from the first dnDSA appearance. Results During 8.3 years of follow-up, graft failure occurred in 33.3% of patients. Baseline eGFR and proteinuria correlated with 5-year graft loss (area under the receiver operating characteristics curve 0.75 and 0.80, P  < .001). Creatinine doubled after a median of 2.8 years [interquartile range (IQR) 1.5–5.0] from dnDSA and the time from doubling creatinine to graft failure was 1.0 year (IQR 0.4–2.9). Analysing eGFR reduction ≥30% as a surrogate endpoint (148/400), the time from dnDSA to this event was 2.0 years (IQR 0.6–4.2), with a positive predictive value (PPV) of 45.9% to predict graft loss, which occurred after 2.0 years (IQR 0.8–3.2). The median time from proteinuria ≥500 mg/g and ≥1000 mg/g to graft failure was identical, 1.8 years, with a PPV of 43.8% and 49.0%, respectively. Composite endpoints did not improve PPV. Multivariable analysis showed that rejection was the most important independent risk factor for all renal endpoints and graft loss. Conclusions Renal function, proteinuria and rejection are strongly associated with graft failure in patients with dnDSA and may serve as surrogate endpoints. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

15. Letermovir Rescue Therapy in Kidney Transplant Recipients with Refractory/Resistant CMV Disease.

Author

von Hoerschelmann, Ellen, Münch, Johannes, Gao, Linde, Lücht, Christian, Naik, Marcel G., Schmidt, Danilo, Pitzinger, Paul, Michel, Detlef, Avaniadi, Parthenopi, Schrezenmeier, Eva, Choi, Mira, Halleck, Fabian, and Budde, Klemens

Subjects
KIDNEY transplantation, CYTOMEGALOVIRUS diseases, REFRACTORY materials, VIRAL load, TREATMENT failure
Abstract

(1) Background: CMV infections remain a problem after kidney transplantation, particularly if patients are refractory or resistant (r/r) to treatment with valganciclovir (VGCV) or ganciclovir (GCV). (2) Methods: In a single-center retrospective study, kidney transplant recipients (KTR) receiving letermovir (LTV) as rescue therapy for VGCV-/GCV-r/r CMV disease were analyzed regarding CMV history, immunosuppression, and outcomes. (3) Results: Of 201 KTR treated for CMV between 2017 and 2022, 8 patients received LTV following treatment failure with VGCV/GCV. All patients received CMV prophylaxis with VGCV according to the center's protocol, and 7/8 patients had a high-risk (D+/R−) CMV constellation. In seven of eight cases, rising CMV levels occurred during prophylaxis. In seven of eight patients, a mutation in UL97 associated with a decreased response to VGCV/GCV was detected. In four of eight patients, LTV resulted in CMV clearance after 24 ± 10 weeks (16–39 weeks), two of eight patients stabilized at viral loads <2000 cop/mL (6–20 weeks), and two of eight patients developed LTV resistance (range 8–10 weeks). (4) Conclusion: LTV, which is currently evaluated for CMV prophylaxis in kidney transplantation, also shows promising results for the treatment of patients with VGCV/GCV resistance despite the risk of developing LTV resistance. Additional studies are needed to further define its role in the treatment of patients with CMV resistance. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

16. COVID-19 Outcomes in Kidney Transplant Recipients in a German Transplant Center

Author

Mikhailov, Michael, primary, Budde, Klemens, additional, Halleck, Fabian, additional, Eleftheriadis, Georgios, additional, Naik, Marcel G., additional, Schrezenmeier, Eva, additional, Bachmann, Friederike, additional, Choi, Mira, additional, Duettmann, Wiebke, additional, von Hoerschelmann, Ellen, additional, Koch, Nadine, additional, Liefeldt, Lutz, additional, Lücht, Christian, additional, Straub-Hohenbleicher, Henriette, additional, Waiser, Johannes, additional, Weber, Ulrike, additional, Zukunft, Bianca, additional, and Osmanodja, Bilgin, additional

Published
2023
Full Text
View/download PDF

19. NephroCAGE—German-Canadian Consortium on AI for Improved Kidney Transplantation Outcome: Protocol for an Algorithm Development and Validation Study (Preprint)

Author

Schapranow, Matthieu-P, primary, Bayat, Mozhgan, additional, Rasheed, Aadil, additional, Naik, Marcel, additional, Graf, Verena, additional, Schmidt, Danilo, additional, Budde, Klemens, additional, Cardinal, Héloïse, additional, Sapir-Pichhadze, Ruth, additional, Fenninger, Franz, additional, Sherwood, Karen, additional, Keown, Paul, additional, Günther, Oliver P, additional, Pandl, Konstantin D, additional, Leiser, Florian, additional, Thiebes, Scott, additional, Sunyaev, Ali, additional, Niemann, Matthias, additional, Schimanski, Andreas, additional, and Klein, Thomas, additional

Published
2023
Full Text
View/download PDF

22. A single centre in-depth analysis of death with a functioning kidney graft and reasons for overall graft failure.

Author

Mayrdorfer, Manuel, Liefeldt, Lutz, Osmanodja, Bilgin, Naik, Marcel G, Schmidt, Danilo, Duettmann, Wiebke, Hammett, Charlotte, Schrezenmeier, Eva, Friedersdorff, Frank, Wu, Kaiyin, Halleck, Fabian, and Budde, Klemens

Subjects
SUDDEN death, KIDNEY transplantation, DEATH rate, CARDIOVASCULAR diseases
Abstract

Background High numbers of unknown classifications and inconsistent methodologies in previous studies make the interpretation of causes leading to graft loss difficult. In addition, data on a holistic view looking at both death with a functioning graft (DWFG) and death-censored graft failure (DCGF) are sparse. Methods In this single-centre study we included 1477 adult kidney transplants performed between 1997 and 2017, of which all 286 DWFGs until the end of observation were analysed and causes for death assigned. Additionally, the results were compared with the causes of 303 DCGFs of the same cohort to evaluate the impact of causes for overall graft loss. Results The most frequent causes for DWFG were cardiovascular disease (CVD) in 30.8%, malignancy in 28.3% and infections in 21%. Only 9.4% of reasons for DWFG were unknown. Sudden death occurred in 40% (35/88) of patients classified as DWFG due to CVD. Overall graft loss was related to the effect of immunosuppression in 36.2% [infection 20.9% (123/589), malignancy 15.3% (90/589)] and CVD in 22.4% (132/589). In 27.4% (161/589), graft failure was associated with underimmunosuppression (rejection). For infections (60 DWFG, 63 DCGF) and CVD (88 DWFG, 44 DCGF), a considerable overlap was observed between DWFG and DCGF. For patients >70 years of age at transplantation, medical events accounted for 78% of overall graft losses and only 6.5% were associated with rejection. Conclusions DWFG and DCGF share more causes for graft loss than previously reported and sudden death plays an underestimated role in death with a functioning graft. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

23. A single centre in-depth analysis of death with a functioning kidney graft and reasons for overall graft failure

Author

Mayrdorfer, Manuel, primary, Liefeldt, Lutz, additional, Osmanodja, Bilgin, additional, Naik, Marcel G, additional, Schmidt, Danilo, additional, Duettmann, Wiebke, additional, Hammett, Charlotte, additional, Schrezenmeier, Eva, additional, Friedersdorff, Frank, additional, Wu, Kaiyin, additional, Halleck, Fabian, additional, and Budde, Klemens, additional

Published
2022
Full Text
View/download PDF

24. Evaluation of a clinical decision support system for detection of patients at risk after kidney transplantation

Author

Roller, Roland, primary, Mayrdorfer, Manuel, additional, Duettmann, Wiebke, additional, Naik, Marcel G., additional, Schmidt, Danilo, additional, Halleck, Fabian, additional, Hummel, Patrik, additional, Burchardt, Aljoscha, additional, Möller, Sebastian, additional, Dabrock, Peter, additional, Osmanodja, Bilgin, additional, and Budde, Klemens, additional

Published
2022
Full Text
View/download PDF

25. The natural history of de novo donor-specific HLA antibodies after kidney transplantation

Author

López del Moral, Covadonga, primary, Wu, Kaiyin, additional, Naik, Marcel, additional, Osmanodja, Bilgin, additional, Akifova, Aylin, additional, Lachmann, Nils, additional, Stauch, Diana, additional, Hergovits, Sabine, additional, Choi, Mira, additional, Bachmann, Friederike, additional, Halleck, Fabian, additional, Schrezenmeier, Eva, additional, Schmidt, Danilo, additional, and Budde, Klemens, additional

Published
2022
Full Text
View/download PDF

28. Poor Outcomes in Patients With Transplant Glomerulopathy Independent of Banff Categorization or Therapeutic Interventions

Author

Wu, Kaiyin, primary, Schmidt, Danilo, additional, López del Moral, Covadonga, additional, Osmanodja, Bilgin, additional, Lachmann, Nils, additional, Halleck, Fabian, additional, Choi, Mira, additional, Bachmann, Friederike, additional, Ronicke, Simon, additional, Duettmann, Wiebke, additional, Naik, Marcel, additional, Schrezenmeier, Eva, additional, Rudolph, Birgit, additional, and Budde, Klemens, additional

Published
2022
Full Text
View/download PDF

30. Sirolimus in renal transplant recipients with malignancies in Germany

Author

Naik, Marcel G., Arns, Wolfgang, Budde, Klemens, Diekmann, Fritz, Eitner, Frank, Gwinner, Wilfried, Heyne, Nils, Jürgensen, Jan Steffen, Morath, Christian, Riester, Udo, Heller, Katharina M., Fischereder, Michael, and German Sirolimus Study Group

Subjects
immunosuppression, sirolimus, graft survival, cancer, kidney transplantation, Original Articles, AcademicSubjects/MED00340, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, multicentre study, survival analysis
Abstract

Clinical kidney journal 14(9), 2047-2058 (2021). doi:10.1093/ckj/sfaa262, Published by Oxford Univ. Press, Oxford

Published
2020

31. Initial Experience With SARS-CoV-2-Neutralizing Monoclonal Antibodies in Kidney or Combined Kidney-Pancreas Transplant Recipients

Author

Bachmann, Friederike, primary, Budde, Klemens, additional, Suttorp, Norbert, additional, Lingscheid, Tilman, additional, Stegemann, Miriam Songa, additional, Osmanodja, Bilgin, additional, Schrezenmeier, Eva, additional, Duettmann, Wiebke, additional, Weber, Ulrike, additional, Naik, Marcel, additional, Lehner, Lukas Johannes, additional, Kahl, Andreas, additional, Duerr, Michael, additional, Eckardt, Kai-Uwe, additional, Waiser, Johannes, additional, Choi, Mira, additional, and Halleck, Fabian, additional

Published
2022
Full Text
View/download PDF

33. Waiting Time for Second Kidney Transplantation and Mortality

Author

Kainz, Alexander, primary, Kammer, Michael, additional, Reindl-Schwaighofer, Roman, additional, Strohmaier, Susanne, additional, Petr, Vojtěch, additional, Viklicky, Ondrej, additional, Abramowicz, Daniel, additional, Naik, Marcel, additional, Mayer, Gert, additional, and Oberbauer, Rainer, additional

Published
2022
Full Text
View/download PDF

34. Poor Long-Term Renal Allograft Survival in Patients with Chronic Antibody-Mediated Rejection, Irrespective of Treatment—A Single Center Retrospective Study

Author

Wu, Kaiyin, primary, Schmidt, Danilo, additional, López del Moral, Covadonga, additional, Osmanodja, Bilgin, additional, Lachmann, Nils, additional, Zhang, Qiang, additional, Halleck, Fabian, additional, Choi, Mira, additional, Bachmann, Friederike, additional, Ronicke, Simon, additional, Duettmann, Wiebke, additional, Naik, Marcel G., additional, Schrezenmeier, Eva, additional, Rudolph, Birgit, additional, and Budde, Klemens, additional

Published
2021
Full Text
View/download PDF

35. Clinicopathologic Features and Risk Factors of Proteinuria in Transplant Glomerulopathy

Author

Zhang, Qiang, Budde, Klemens, Schmidt, Danilo, Halleck, Fabian, Duerr, Michael, Naik, Marcel G., Mayrdorfer, Manuel, Duettmann, Wiebke, Klauschen, Frederick, Rudolph, Birgit, and Wu, Kaiyin

Subjects
renal biopsy, graft function, Medicine, blood pressure, kidney transplantation, proteinuria, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, Original Research
Abstract

Background: Transplant glomerulopathy (TG) is one of the main causes of post-transplant proteinuria (PU). The features and possible risk factors for proteinuria in TG patients are uncertain. Methods: We investigated all patients who had biopsy-proven TG from 2000 to 2018 in our center. The clinical and histological data were compared between two groups with or without PU (cut-off = 0.3 g/day). Spearman correlation analysis was used to evaluate the relationship between PU and pathological changes. The risk factors for PU in TG patients were determined by multivariable logistic regression analysis. Results: One hundred and twenty-five (75.76%) of all enrolled 165 TG patients had proteinuria ≥0.3 g/day at the time of biopsy. TG patients' PU level was significantly correlated with Banff lesion score cg (ρ = 0.247, P = 0.003), and mm (ρ = 0.257, P = 0.012). Systolic blood pressure ≥140 mmHg (OR 2.72, 95% CI 1.04-7.10, P = 0.041), diastolic blood pressure ≥90 mmHg (OR 4.84, 95% CI 1.39-16.82, P = 0.013), peak PRA ≥5% (OR 6.47, 95% CI 1.67-25.01, P = 0.007), positive C4d staining (OR 4.55, 95% CI 1.29-16.11, 0.019), tacrolimus-based regimen (OR 3.5, 95% CI 1.28-9.54, P = 0.014), and calcium channel blocker usage (OR 4.38, 95% CI 1.59-12.09, P = 0.004) were independent risk factors for PU. Conclusions: Proteinuria is common in TG patients. systolic blood pressure ≥140 mmHg, diastolic blood pressure ≥90 mmHg, peak PRA ≥5%, positive C4d staining, tacrolimus-based regimen, and calcium channel blocker usage are associated with proteinuria in TG patients.

Published
2021

37. Exploring the Complexity of Death-Censored Kidney Allograft Failure

Author

Mayrdorfer, Manuel, primary, Liefeldt, Lutz, additional, Wu, Kaiyin, additional, Rudolph, Birgit, additional, Zhang, Qiang, additional, Friedersdorff, Frank, additional, Lachmann, Nils, additional, Schmidt, Danilo, additional, Osmanodja, Bilgin, additional, Naik, Marcel G., additional, Duettmann, Wiebke, additional, Halleck, Fabian, additional, Merkel, Marina, additional, Schrezenmeier, Eva, additional, Waiser, Johannes, additional, Duerr, Michael, additional, and Budde, Klemens, additional

Published
2021
Full Text
View/download PDF

38. Accuracy of a Novel SARS-CoV-2 Antigen-Detecting Rapid Diagnostic Test from Standardized Self-Collected Anterior Nasal Swabs

Author

Osmanodja, Bilgin, primary, Budde, Klemens, additional, Zickler, Daniel, additional, Naik, Marcel G., additional, Hofmann, Jörg, additional, Gertler, Maximilian, additional, Hülso, Claudia, additional, Rössig, Heike, additional, Horn, Philipp, additional, Seybold, Joachim, additional, Lunow, Stephanie, additional, Bothmann, Melanie, additional, Barrera-Pesek, Astrid, additional, and Mayrdorfer, Manuel, additional

Published
2021
Full Text
View/download PDF

41. MO105TELEMEDICAL SURVEILLANCE AND OPTIMIZED TREATMENT OF BLOOD PRESSURE IN KIDNEY TRANSPLANT RECIPIENTS

Author

Duettmann, Wiebke, primary, Naik, Marcel, additional, Zukunft, Bianca, additional, Schmidt, Danilo, additional, Glander, Petra, additional, Osmanodja, Bilgin, additional, Mayrdorfer, Manuel, additional, Choi, Mira, additional, Bachmann, Friederike, additional, Weber, Ulrike, additional, Graf, Verena, additional, Dürr, Michael, additional, Halleck, Fabian, additional, and Budde, Klemens, additional

Published
2021
Full Text
View/download PDF

42. Diagnostic accuracy of a novel SARS-CoV-2 antigen-detecting rapid diagnostic test from standardized self-collected anterior nasal swabs

Author

Osmanodja, Bilgin, primary, Budde, Klemens, additional, Zickler, Daniel, additional, Naik, Marcel G., additional, Hofmann, Jörg, additional, Gertler, Maximilian, additional, Hülso, Claudia, additional, Rössig, Heike, additional, Horn, Philipp, additional, Seybold, Joachim, additional, Lunow, Stephanie, additional, Bothmann, Melanie, additional, Barrera-Pesek, Astrid, additional, and Mayrdorfer, Manuel, additional

Published
2021
Full Text
View/download PDF

43. Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Author

Duettmann, Wiebke, primary, Naik, Marcel G., primary, Schmidt, Danilo, primary, Pfefferkorn, Matthias, primary, Kurz, Matthias, primary, Graf, Verena, primary, Kreichgauer, Andrea, primary, Hoegl, Severin, primary, Haenska, Max, primary, Gielsdorf, Tim, primary, Breitenstein, Tillmann, primary, Osmanodja, Bilgin, primary, Glander, Petra, primary, Bakker, Jannis, primary, Mayrdorfer, Manuel, primary, Gethmann, Carolin J., primary, Bachmann, Friederike, primary, Choi, Mira, primary, Schrezenmeier, Eva, primary, Zukunft, Bianca, primary, Halleck, Fabian, primary, and Budde, Klemens, primary

Published
2021
Full Text
View/download PDF

45. What happens after graft loss? A large, long‐term, single‐center observation

Author

Schrezenmeier, Eva, primary, Lehner, Lukas J., additional, Merkel, Marina, additional, Mayrdorfer, Manuel, additional, Duettmann, Wiebke, additional, Naik, Marcel G., additional, Fröhlich, Felix, additional, Liefeldt, Lutz, additional, Pigorsch, Mareen, additional, Friedersdorff, Frank, additional, Schmidt, Danilo, additional, Niemann, Matthias, additional, Lachmann, Nils, additional, Budde, Klemens, additional, and Halleck, Fabian, additional

Published
2021
Full Text
View/download PDF

46. The relationship between proteinuria and allograft survival in patients with transplant glomerulopathy: a retrospective single‐center cohort study

Author

Zhang, Qiang, primary, Rudolph, Birgit, additional, Choi, Mira, additional, Bachmann, Friederike, additional, Schmidt, Danilo, additional, Duerr, Michael, additional, Naik, Marcel G., additional, Duettmann, Wiebke, additional, Schrezenmeier, Eva, additional, Mayrdorfer, Manuel, additional, Halleck, Fabian, additional, Wu, Kaiyin, additional, and Budde, Klemens, additional

Published
2021
Full Text
View/download PDF

48. Determinants of Successful Use of Sirolimus in Renal Transplant Patients

Author

Naik, Marcel G., primary, Jürgensen, Jan Steffen, additional, Arns, Wolfgang, additional, Basic, Edin, additional, Budde, Klemens, additional, Eitner, Frank, additional, Fischereder, Michael, additional, Goßmann, Jan, additional, Heller, Katharina M., additional, Heyne, Nils, additional, Morath, Christian, additional, Riester, Udo, additional, Diekmann, Fritz, additional, and Gwinner, Wilfried, additional

Published
2020
Full Text
View/download PDF

50. eHealth in transplantation

Author

Duettmann, Wiebke, primary, Naik, Marcel G., additional, Zukunft, Bianca, additional, Osmonodja, Bilgin, additional, Bachmann, Friederike, additional, Choi, Mira, additional, Roller, Roland, additional, Mayrdorfer, Manuel, additional, Halleck, Fabian, additional, Schmidt, Danilo, additional, and Budde, Klemens, additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results