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3. A multi-center study on safety and efficacy of immune checkpoint inhibitors in cancer patients with kidney transplant

Author

Murakami, Naoka, Mulvaney, Patrick, Danesh, Melissa, Abudayyeh, Ala, Diab, Adi, Abdel-Wahab, Noha, Abdelrahim, Maen, Khairallah, Pascale, Shirazian, Shayan, Kukla, Aleksandra, Owoyemi, Itunu O, Alhamad, Tarek, Husami, Samir, Menon, Madhav, Santeusanio, Andrew, Blosser, Christopher D, Zuniga, Sandra Carias, Soler, Maria Jose, Moreso, Francesc, Mithani, Zain, Ortiz-Melo, David, Jaimes, Edgar A, Gutgarts, Victoria, Lum, Erik, Danovitch, Gabriel M, Cardarelli, Francesca, Drews, Reed E, Bassil, Claude, Swank, Jennifer L, Westphal, Scott, Mannon, Roslyn B, Shirai, Keisuke, Kitchlu, Abhijat, Ong, Song, Machado, Shana M, Mothi, Suraj S, Ott, Patrick A, Rahma, Osama, Hodi, F Stephen, Sise, Meghan E, Gupta, Shruti, Leaf, David E, Devoe, Craig E, Wanchoo, Rimda, Nair, Vinay V, Schmults, Chrysalyne D, Hanna, Glenn J, Sprangers, Ben, Riella, Leonardo V, Jhaveri, Kenar D, and Consortium, Immune Checkpoint Inhibitors in Solid Organ Transplant

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Immunology, Organ Transplantation, Kidney Disease, Transplantation, Cancer, Rare Diseases, Clinical Research, Prevention, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, 6.4 Surgery, Renal and urogenital, Carcinoma, Squamous Cell, Humans, Immune Checkpoint Inhibitors, Kidney Transplantation, Prospective Studies, Retrospective Studies, Skin Neoplasms, immune checkpoint inhibitors, kidney transplant, onconephrology, rejection, Immune Checkpoint Inhibitors in Solid Organ Transplant Consortium, Urology & Nephrology, Clinical sciences
Abstract

Immune checkpoint inhibitors (ICIs) are widely used for various malignancies. However, their safety and efficacy in patients with a kidney transplant have not been defined. To delineate this, we conducted a multicenter retrospective study of 69 patients with a kidney transplant receiving ICIs between January 2010 and May 2020. For safety, we assessed the incidence, timing, and risk factors of acute graft rejection. For efficacy, objective response rate and overall survival were assessed in cutaneous squamous cell carcinoma and melanoma, the most common cancers in our cohort, and compared with stage-matched 23 patients with squamous cell carcinoma and 14 with melanoma with a kidney transplant not receiving ICIs. Following ICI treatment, 29 out of 69 (42%) patients developed acute rejection, 19 of whom lost their allograft, compared with an acute rejection rate of 5.4% in the non-ICI cohort. Median time from ICI initiation to rejection was 24 days. Factors associated with a lower risk of rejection were mTOR inhibitor use (odds ratio 0.26; 95% confidence interval, 0.09-0.72) and triple-agent immunosuppression (0.67, 0.48-0.92). The objective response ratio was 36.4% and 40% in the squamous cell carcinoma and melanoma subgroups, respectively. In the squamous cell carcinoma subgroup, overall survival was significantly longer in patients treated with ICIs (median overall survival 19.8 months vs. 10.6 months), whereas in the melanoma subgroup, overall survival did not differ between groups. Thus, ICIs were associated with a high risk of rejection in patients with kidney transplants but may lead to improved cancer outcomes. Prospective studies are needed to determine optimal immunosuppression strategies to improve patient outcomes.

Published
2021

4. Posoleucel in Kidney Transplant Recipients with BK Viremia: Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial

Author

Chandraker, Anil, Regmi, Anil, Gohh, Reginald, Sharma, Akhil, Woodle, E. Steve, Ansari, Mohammed J., Nair, Vinay, Chen, Ling-Xin, Alhamad, Tarek, Norman, Silas, Cibrik, Diane, Singh, Manpreet, Alper, Arnold, Jain, Divya, Zaky, Ziad, Knechtle, Stuart, Sharfuddin, Asif, Gupta, Gaurav, Lonze, Bonnie E., Young, Jo-Anne H., Adey, Deborah, Faravardeh, Arman, Dadhania, Darshana M., Rossi, Ana P., Florescu, Diana, Cardarelli, Francesca, Ma, Julie, Gilmore, Sarah, Vasileiou, Spyridoula, Jindra, Peter T., and Wojciechowski, David

Published
2024
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8. An early experience on the effect of solid organ transplant status on hospitalized COVID-19 patients

Author

Nair, Vinay, Jandovitz, Nicholas, Hirsch, Jamie S., Abate, Mersema, Satapathy, Sanjaya K., Roth, Nitzan, Miyara, Santiago J., Guevara, Sara, Kressel, Adam M., Xiang, Alec, Wu, Grace, Butensky, Samuel D., Lin, David, Williams, Stephanie, Bhaskaran, Madhu C., Majure, David T., Grodstein, Elliot, Lau, Lawrence, Nair, Gayatri, Fahmy, Ahmed E., Winnick, Aaron, Breslin, Nadine, Berlinrut, Ilan, Molmenti, Christine, Becker, Lance B., Malhotra, Prashant, Gautam-Goyal, Pranisha, Lima, Brian, Maybaum, Simon, Shah, Samit K., Takegawa, Ryosuke, Hayashida, Kei, Shinozaki, Koichiro, Teperman, Lewis W., and Molmenti, Ernesto P.

Published
2021
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9. Outcomes Among Patients Hospitalized With COVID-19 and Acute Kidney Injury

Author

Abate, Mersema, Andrade, Hugo Paz, Barnett, Richard L., Bellucci, Alessandro, Bhaskaran, Madhu C., Corona, Antonio G., Flores Chang, Bessy Suyin, Finger, Mark, Fishbane, Steven, Gitman, Michael, Halinski, Candice, Hasan, Shamir, Hazzan, Azzour D., Hirsch, Jamie S., Hong, Susana, Jhaveri, Kenar D., Khanin, Yuriy, Kuan, Aireen, Madireddy, Varun, Malieckal, Deepa, Muzib, Abdulrahman, Nair, Gayatri, Nair, Vinay V., Ng, Jia Hwei, Parikh, Rushang, Ross, Daniel W., Sakhiya, Vipulbhai, Sachdeva, Mala, Schwarz, Richard, Shah, Hitesh H., Sharma, Purva, Singhal, Pravin C., Uppal, Nupur N., Wanchoo, Rimda, Ng, Jia H., Hazzan, Azzour, and Malieckal, Deepa A.

Published
2021
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11. Outcomes of patients with end-stage kidney disease hospitalized with COVID-19

Author

Abate, Mersema, Andrade, Hugo Paz, Barnett, Richard L., Bellucci, Alessandro, Bhaskaran, Madhu C., Corona, Antonio G., Flores Chang, Bessy Suyin, Finger, Mark, Fishbane, Steven, Gitman, Michael, Halinski, Candice, Hasan, Shamir, Hazzan, Azzour D., Hong, Susana, Khanin, Yuriy, Kuan, Aireen, Madireddy, Varun, Malieckal, Deepa, Muzib, Abdulrahman, Nair, Gayatri, Ng, Jia Hwei, Parikh, Rushang, Ross, Daniel W., Sakhiya, Vipulbhai, Sachdeva, Mala, Schwarz, Richard, Shah, Hitesh H., Sharma, Purva, Singhal, Pravin C., Uppal, Nupur N., Wanchoo, Rimda, Hirsch, Jamie S., Jhaveri, Kenar D., Nair, Vinay V., and Ng, Jia H.

Published
2020
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13. COVID-19 in kidney transplant recipients

Author

Nair, Vinay, Jandovitz, Nicholas, Hirsch, Jamie S., Nair, Gayatri, Abate, Mersema, Bhaskaran, Madhu, Grodstein, Elliot, Berlinrut, Ilan, Hirschwerk, David, Cohen, Stuart L., Davidson, Karina W., Dominello, Andrew J., Osorio, Gabrielle A., Richardson, Safiya, Teperman, Lewis W., and Molmenti, Ernesto P.

Published
2020
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14. Acute kidney injury in patients hospitalized with COVID-19

Author

Abate, Mersema, Andrade, Hugo Paz, Barnett, Richard L., Bellucci, Alessandro, Bhaskaran, Madhu C., Corona, Antonio G., Chang, Bessy Flores, Finger, Mark, Fishbane, Steven, Gitman, Michael, Halinski, Candice, Hasan, Shamir, Hazzan, Azzour D., Hirsch, Jamie S., Hong, Susana, Jhaveri, Kenar D., Khanin, Yuriy, Kuan, Aireen, Madireddy, Varun, Malieckal, Deepa, Muzib, Abdulrahman, Nair, Gayatri, Nair, Vinay V., Ng, Jia H., Parikh, Rushang, Ross, Daniel W., Sakhiya, Vipulbhai, Sachdeva, Mala, Schwarz, Richard, Shah, Hitesh H., Sharma, Purva, Singhal, Pravin C., Uppal, Nupur N., Wanchoo, Rimda, Bessy Suyin Flores Chang, and Ng, Jia Hwei.

Published
2020
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18. The SAP Activate Method and Corresponding SPICE Models

Author

Scheck, Ansgar, Siemens, Gerhard, Schweigert, Tomas, Nair, Vinay, Barbosa, Simone Diniz Junqueira, Editorial Board Member, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Kotenko, Igor, Editorial Board Member, Yuan, Junsong, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Walker, Alastair, editor, O'Connor, Rory V., editor, and Messnarz, Richard, editor

Published
2019
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23. Rapid Biolayer Interferometry Measurements of Urinary CXCL9 to Detect Cellular Infiltrates Noninvasively After Kidney Transplantation

Author

Gandolfini, Ilaria, Harris, Cynthia, Abecassis, Michael, Anderson, Lisa, Bestard, Oriol, Comai, Giorgia, Cravedi, Paolo, Cremaschi, Elena, Duty, J. Andrew, Florman, Sander, Friedewald, John, La Manna, Gaetano, Maggiore, Umberto, Moran, Thomas, Piotti, Giovanni, Purroy, Carolina, Jarque, Marta, Nair, Vinay, Shapiro, Ron, Reid-Adam, Jessica, and Heeger, Peter S.

Published
2017
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26. Glowworm Swarm Based Informative Attribute Selection Using Support Vector Machines for Simultaneous Feature Selection and Classification

Author

Gurav, Aniket, Nair, Vinay, Gupta, Utkarsh, Valadi, Jayaraman, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Panigrahi, Bijaya Ketan, editor, Suganthan, Ponnuthurai Nagaratnam, editor, and Das, Swagatam, editor

Published
2015
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28. Contributors for Volume 2

Author

Agarwal, Anil Kumar, Al lami, Zahraa, Ala, Aftab, Anand, Anil C., Anirvan, Prajna, Arab, Juan P., Bagwan, Izhar, Bahure, Upasna, Baloji, Abhiman, Bataller, Ramon, Batsis, Irini, Behera, Manas Kumar, Berlinrut, Ilan, Bhamidimarri, Kalyan Ram, Bhongade, Megha, Bhujade, Harish, Bucuvalas, John C., Chayanupatkul, Maneerat, Clemente-Sanchez, Ana, Cussen, Christopher, De, Arka, Dieterich, Douglas T., DiNorcia, Joseph, Dunn, Winston, Duseja, Ajay, El Sabagh, Ahmed, El Talkhan, Mohamed, Em, Makkalon, Gupta, Sunita, Huisman, Tsipora M., Ilyas, Fariha, Jain, Shilpa, Jalal, Prasun K., Kalra, Naveen, Kamani, Lubna, Khandelwal, R., Khuroo, Mohammad Sultan, Khuroo, Naira Sultan, Kim, Edward, Liu Yin, James, Maiwall, R., Mallakmir, Snehal, Mehta, Heer, Mohamed, Islam B., Molmenti, Alexia, Molmenti, Ernesto P., Nagral, Aabha, Nair, Vinay, Odin, Joseph A, Panigrahi, Manas, Pena Polanco, Nathalie A., Prachanronarong, Kristina, Praharaj, Dibya L., Raja, Kishor, Satapathy, Sanjaya K., Schiano, Thomas D., Schilsky, Michael L., Singal, Ashwani K., Singh, Shivaram Prasad, Smith, Rachel W., To, Uyen, Vanatta, Jason M., Wallach, Frances, and ZainAloor, Fuad

Published
2025
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30. Life-Threatening Hematuria as Initial Presentation of a Complicated Transplant Renal Artery Pseudoaneurysm.

Author

Miyara, Santiago J., Becker, Lance B., Guevara, Sara, Lau, Lawrence, Nair, Vinay V., Jandovitz, Nicholas, Fahmy, Ahmed E., Grodstein, Elliot, Winnick, Aaron M., Kirsch, Claudia, Rolston, Daniel M., Bhaskaran, Madhu C., Hayashida, Kei, Shinozaki, Koichiro, Takegawa, Ryosuke, Cho, Young Min, Cagliani, Joaquin A., Isa, Arton, Al-Roubaie, Mustafa, and Krishnasastry, K. V.

Published
2023
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36. Targeting Medium-Chain Acyl-CoA Dehydrogenase for Glioblastoma

Author

Yu, Fei, primary, Leonard, Paul, additional, Hamilton, Matthew, additional, Puca, Francesca, additional, Pham, Nhung, additional, Rogers, Norma, additional, Alvarez, Fernando, additional, Rodriguez, C, additional, Nair, Vinay, additional, Akkaladevi, Narahari, additional, Thapar, Roopa, additional, Vaccaro, Scott, additional, Mendiola, Andrea, additional, Xu, Quanyun, additional, Do, Mary Geck, additional, Cross, Jason, additional, Soth, Mick, additional, Jiang, Yongying, additional, Draetta, Giulio, additional, and Jones, Philip, additional

Published
2022
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39. Right Ventricle Embolization of IVC Filter Fragments: An Incidental Finding

Author

Miyara, Santiago J., additional, Guevara, Sara, additional, Shore-Lesserson, Linda, additional, Shoaib, Muhammad, additional, Kirsch, Claudia, additional, Metz, Christine N., additional, Nair, Vinay, additional, Lau, Lawrence, additional, Choudhary, Rishabh C., additional, McCann-Molmenti, Alexia, additional, Baez, Anthony M., additional, Hayashida, Kei, additional, Takegawa, Ryosuke, additional, Shinozaki, Koichiro, additional, Aoki, Tomoaki, additional, Nishikimi, Mitsuaki, additional, Cho, Young Min, additional, Morell, Alexis, additional, Zafeiropoulos, Stefanos, additional, Zanos, Stavros, additional, Watt, Stacey, additional, Montorfano, Lisandro, additional, Bartoc, Cristian D., additional, Lumermann, Claudio M., additional, Aronsohn, Judith, additional, Becker, Lance B., additional, and Molmenti, Ernesto P., additional

Published
2021
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40. Immune checkpoint inhibitors in kidney transplant patients: a multi-center study

Author

Murakami, Naoka, Mulvaney, Patrick, Danesh, Melissa, Abudayyeh, Ala, Diab, Adi, Abdel-Wahab, Noha, Abdelrahim, Maen, Khairallah, Pascale, Shirazian, Shayan, Kukla, Aleksandra, Owoyemi, Itunu O., Alhamad, Tarek, Husami, Samir, Menon, Madhav, Santeusanio, Andrew, Blosser, Christopher, Zuniga, Sandra Carias, Soler, Maria Jose, Moreso, Francesc, Mithani, Zain, Ortiz-Melo, David, Jaimes, Edgar A., Gutgarts, Victoria, Lum, Erik, Danovitch, Gabriel M., Cardarelli, Francesca, Drews, Reed E., Bassil, Claude, Swank, Jennifer L., Westphal, Scott, Mannon, Roslyn B., Shirai, Keisuke, Kitchlu, Abhijat, Ong, Song, Machado, Shana M., Mothi, Suraj S., Ott, Patrick A., Rahma, Osama, Hodi, F. Stephen, Sise, Meghan E., Gupta, Shruti, Leaf, David E., Devoe, Craig E., Wanchoo, Rimda, Nair, Vinay V., Schmults, Chrysalyne D., Hanna, Glenn J., Sprangers, Ben, Riella, Leonardo V., and Jhaveri, Kenar D.

Subjects
Skin Neoplasms, Carcinoma, Squamous Cell, Humans, Prospective Studies, Immune Checkpoint Inhibitors, Kidney Transplantation, Article, Retrospective Studies
Abstract

Immune checkpoint inhibitors (ICIs) are widely used for various malignancies. However, their safety and efficacy in patients with a kidney transplant have not been defined. To delineate this, we conducted a multicenter retrospective study of 69 patients with a kidney transplant receiving ICIs between January 2010 and May 2020. For safety, we assessed the incidence, timing, and risk factors of acute graft rejection. For efficacy, objective response rate and overall survival were assessed in cutaneous squamous cell carcinoma and melanoma, the most common cancers in our cohort, and compared with stage-matched 23 patients with squamous cell carcinoma and 14 with melanoma with a kidney transplant not receiving ICIs. Following ICI treatment, 29 out of 69 (42%) patients developed acute rejection, 19 of whom lost their allograft, compared with an acute rejection rate of 5.4% in the non-ICI cohort. Median time from ICI initiation to rejection was 24 days. Factors associated with a lower risk of rejection were mTOR inhibitor use (odds ratio 0.26; 95% confidence interval, 0.09-0.72) and triple-agent immunosuppression (0.67, 0.48-0.92). The objective response ratio was 36.4% and 40% in the squamous cell carcinoma and melanoma subgroups, respectively. In the squamous cell carcinoma subgroup, overall survival was significantly longer in patients treated with ICIs (median overall survival 19.8 months vs. 10.6 months), whereas in the melanoma subgroup, overall survival did not differ between groups. Thus, ICIs were associated with a high risk of rejection in patients with kidney transplants but may lead to improved cancer outcomes. Prospective studies are needed to determine optimal immunosuppression strategies to improve patient outcomes.

Published
2020

41. Pneumatosis Intestinalis in the Setting of COVID-19: A Single Center Case Series From New York

Author

Miyara, Santiago J., primary, Becker, Lance B., additional, Guevara, Sara, additional, Kirsch, Claudia, additional, Metz, Christine N., additional, Shoaib, Muhammad, additional, Grodstein, Elliot, additional, Nair, Vinay V., additional, Jandovitz, Nicholas, additional, McCann-Molmenti, Alexia, additional, Hayashida, Kei, additional, Takegawa, Ryosuke, additional, Shinozaki, Koichiro, additional, Yagi, Tsukasa, additional, Aoki, Tomoaki, additional, Nishikimi, Mitsuaki, additional, Choudhary, Rishabh C., additional, Cho, Young Min, additional, Zanos, Stavros, additional, Zafeiropoulos, Stefanos, additional, Hoffman, Hannah B., additional, Watt, Stacey, additional, Lumermann, Claudio M., additional, Aronsohn, Judith, additional, Shore-Lesserson, Linda, additional, and Molmenti, Ernesto P., additional

Published
2021
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43. Governance mechanisms and equity prices

Author

Cremers, Martijn K.J. and Nair, Vinay B.

Subjects
Corporate governance -- Management, Shareholder activism -- Management, Equity (Finance) -- Prices and rates, Company business management, Company pricing policy, Banking, finance and accounting industries, Business
Abstract

The interaction and effects of corporate external governance and internal shareholder governance on the firm's equity prices are evaluated.

Published
2005

44. Kidney transplantation in patients with multiple myeloma: narrative analysis and review of the last two decades.

Author

Chitty, David W, Hartley-Brown, Monique A, Abate, Mersema, Thakur, Richa, Wanchoo, Rimda, Jhaveri, Kenar D, and Nair, Vinay

Subjects
MULTIPLE myeloma, KIDNEY transplantation, KIDNEY diseases, PARAPROTEINEMIA, TREATMENT effectiveness, OVERALL survival
Abstract

There have been significant advances in the treatment of multiple myeloma in the last two decades. Approximately 25% of patients with newly diagnosed myeloma have some degree of kidney impairment. During the course of illness, nearly 50% of myeloma patients will develop kidney disease. Moreover, ∼10% of myeloma patients have advanced kidney disease requiring dialysis at presentation. Hemodialysis is associated with a significantly reduced overall survival (OS). In the setting of prolonged long-term OS due to the use of newer immunotherapeutic agents in the treatment of myeloma, patients with myeloma and advanced kidney disease may benefit from more aggressive management with kidney transplantation (KTx). Unfortunately, most data regarding outcomes of KTx in patients with myeloma come from single-center case series. With the advent of novel treatment choices, it remains unclear if outcomes of kidney transplant recipients with myeloma have improved in recent years. In this descriptive systematic review, we coalesced published patient data over the last 20 years to help inform clinicians and patients on expected hematologic and KTx outcomes in this complex population. We further discuss the future of KTx in patients with paraproteinemia. [ABSTRACT FROM AUTHOR]

Published
2022
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48. Outcomes Among Patients Hospitalized With COVID-19 and Acute Kidney Injury

Author

Ng, Jia H., primary, Hirsch, Jamie S., additional, Hazzan, Azzour, additional, Wanchoo, Rimda, additional, Shah, Hitesh H., additional, Malieckal, Deepa A., additional, Ross, Daniel W., additional, Sharma, Purva, additional, Sakhiya, Vipulbhai, additional, Fishbane, Steven, additional, Jhaveri, Kenar D., additional, Abate, Mersema, additional, Andrade, Hugo Paz, additional, Barnett, Richard L., additional, Bellucci, Alessandro, additional, Bhaskaran, Madhu C., additional, Corona, Antonio G., additional, Flores Chang, Bessy Suyin, additional, Finger, Mark, additional, Gitman, Michael, additional, Halinski, Candice, additional, Hasan, Shamir, additional, Hazzan, Azzour D., additional, Hong, Susana, additional, Khanin, Yuriy, additional, Kuan, Aireen, additional, Madireddy, Varun, additional, Malieckal, Deepa, additional, Muzib, Abdulrahman, additional, Nair, Gayatri, additional, Nair, Vinay V., additional, Ng, Jia Hwei, additional, Parikh, Rushang, additional, Sachdeva, Mala, additional, Schwarz, Richard, additional, Singhal, Pravin C., additional, and Uppal, Nupur N., additional

Published
2021
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