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205 results on '"Naito, Masafumi"'

1. Clinical Outcomes in Biopsy-Proven Nonalcoholic Fatty Liver Disease Patients: A Multicenter Registry-based Cohort Study

Author

Fujii, Hideki, Iwaki, Michihiro, Hayashi, Hideki, Toyoda, Hidenori, Oeda, Satoshi, Hyogo, Hideyuki, Kawanaka, Miwa, Morishita, Asahiro, Munekage, Kensuke, Kawata, Kazuhito, Yamamura, Sakura, Sawada, Koji, Maeshiro, Tatsuji, Tobita, Hiroshi, Yoshida, Yuichi, Naito, Masafumi, Araki, Asuka, Arakaki, Shingo, Kawaguchi, Takumi, Noritake, Hidenao, Ono, Masafumi, Masaki, Tsutomu, Yasuda, Satoshi, Tomita, Eiichi, Yoneda, Masato, Kawada, Norifumi, Tokushige, Akihiro, Kamada, Yoshihiro, Takahashi, Hirokazu, Ueda, Shinichiro, Aishima, Shinichi, Sumida, Yoshio, Nakajima, Atsushi, and Okanoue, Takeshi

Published
2023
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2. Validation of Noninvasive Markers for HCC Risk Stratification in 1389 Patients With Biopsy-proven NAFLD

Author

Toyoda, Hidenori, Fujii, Hideki, Iwaki, Michihiro, Hayashi, Hideki, Oeda, Satoshi, Hyogo, Hideyuki, Kawanaka, Miwa, Morishita, Asahiro, Munekage, Kensuke, Kawata, Kazuhito, Yamamura, Sakura, Sawada, Koji, Maeshiro, Tatsuji, Tobita, Hiroshi, Yoshida, Yuichi, Naito, Masafumi, Araki, Asuka, Arakaki, Shingo, Kawaguchi, Takumi, Noritake, Hidenao, Ono, Masafumi, Masaki, Tsutomu, Yasuda, Satoshi, Tomita, Eiichi, Yoneda, Masato, Kawada, Norifumi, Tokushige, Akihiro, Kamada, Yoshihiro, Takahashi, Hirokazu, Ueda, Shinichiro, Aishima, Shinichi, Sumida, Yoshio, Nakajima, Atsushi, and Okanoue, Takeshi

Published
2023
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3. Validation study of age‐independent fibrosis score (Fibrosis‐3 index) in patients with metabolic dysfunction‐associated steatotic liver disease.

Author

Nouso, Kazuhiro, Kawanaka, Miwa, Fujii, Hideki, Kariyama, Kazuya, Toyoda, Hidenori, Iwaki, Michihiro, Hayashi, Hideki, Oeda, Satoshi, Hyogo, Hideyuki, Morishita, Asahiro, Munekage, Kensuke, Kawata, Kazuhito, Tsutsumi, Tsubasa, Sawada, Koji, Maeshiro, Tatsuji, Tobita, Hiroshi, Yoshida, Yuichi, Naito, Masafumi, Araki, Asuka, and Arakaki, Shingo

Subjects
HEPATIC fibrosis, RECEIVER operating characteristic curves, TREATMENT effectiveness, AGE groups, LIVER diseases
Abstract

Background and Aims: Because the accuracy of the Fibrosis‐4 (FIB‐4) index for predicting liver fibrosis changes with age, the need for different cut‐offs in various age groups has frequently been discussed. We developed the age‐independent score, the Fibrosis‐3 (FIB‐3) index, and have shown its usefulness in patients with metabolic dysfunction‐associated steatotic liver disease (MASLD). This study aimed to validate the diagnostic ability of the FIB‐3 index to predict fibrosis progression using a large new patient cohort. Methods: The ability of the FIB‐3 index to predict liver fibrosis was analyzed by comparing it with that of the FIB‐4 index using data from 1398 patients with MASLD enrolled in the Asia‐based clinical outcome NAFLD study. Results: The areas under the receiver operating characteristic curves for predicting fibrosis stage F3 or higher were not different between the FIB‐3 and FIB‐4 indices in the entire cohort. Using the single ideal cut‐offs of the indices (3.41 for FIB‐3 index and 2.01 for FIB‐4 index), the predictive accuracy of the FIB‐3 index was not significantly different from that of the FIB‐4 index among patients aged <60 years; however, the accuracy of the FIB‐3 index was significantly higher than that of the FIB‐4 index in those aged ≥60 years (0.645 and 0.529, respectively; p < 0.0001). Conclusion: The high ability of the FIB‐3 index with a single cut‐off to predict liver fibrosis in patients with MASLD was confirmed. The FIB‐3 index could serve as a useful tool for assessing liver fibrosis regardless of age. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Hepatic inflammation and fibrosis are profiles related to mid‐term mortality in biopsy‐proven MASLD: A multicenter study in Japan

Author

Tsutsumi, Tsubasa, primary, Kawaguchi, Takumi, additional, Fujii, Hideki, additional, Kamada, Yoshihiro, additional, Takahashi, Hirokazu, additional, Kawanaka, Miwa, additional, Sumida, Yoshio, additional, Iwaki, Michihiro, additional, Hayashi, Hideki, additional, Toyoda, Hidenori, additional, Oeda, Satoshi, additional, Hyogo, Hideyuki, additional, Morishita, Asahiro, additional, Munekage, Kensuke, additional, Kawata, Kazuhito, additional, Sawada, Koji, additional, Maeshiro, Tatsuji, additional, Tobita, Hiroshi, additional, Yoshida, Yuichi, additional, Naito, Masafumi, additional, Araki, Asuka, additional, Arakaki, Shingo, additional, Noritake, Hidenao, additional, Ono, Masafumi, additional, Masaki, Tsutomu, additional, Yasuda, Satoshi, additional, Tomita, Eiichi, additional, Yoneda, Masato, additional, Tokushige, Akihiro, additional, Ueda, Shinichiro, additional, Aishima, Shinichi, additional, Nakajima, Atsushi, additional, and Okanoue, Takeshi, additional

Published
2024
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6. Age‐dependent effects of diabetes and obesity on liver‐related events in non‐alcoholic fatty liver disease: Subanalysis of CLIONE in Asia

Author

Seko, Yuya, Kawanaka, Miwa, Fujii, Hideki, Iwaki, Michihiro, Hayashi, Hideki, Toyoda, Hidenori, Oeda, Satoshi, Hyogo, Hideyuki, Morishita, Asahiro, Munekage, Kensuke, Kawata, Kazuhito, Yamamura, Sakura, Sawada, Koji, Maeshiro, Tatsuji, Tobita, Hiroshi, Yoshida, Yuichi, Naito, Masafumi, Araki, Asuka, Arakaki, Shingo, Kawaguchi, Takumi, Noritake, Hidenao, Ono, Masafumi, Masaki, Tsutomu, Yasuda, Satoshi, Tomita, Eiichi, Yoneda, Masato, Tokushige, Akihiro, Kamada, Yoshihiro, Takahashi, Hirokazu, Ueda, Shinichiro, Aishima, Shinichi, Sumida, Yoshio, Okanoue, Takeshi, Itoh, Yoshito, Nakajima, Atsushi, and Japan Study Group of Nonalcoholic Fatty Liver Disease

Subjects
2型糖尿病, nonalcoholic fatty liver disease, Carcinoma, Hepatocellular, 肝細胞癌, type 2 diabetes mellitus, CLIONE in Asia, 肥満, BMI, Non-alcoholic Fatty Liver Disease, Humans, Animals, Obesity, nonalcoholic steatohepatitis, Retrospective Studies, 線維症, Clione, Hepatology, Liver Neoplasms, Gastroenterology, hepatocellular carcinoma, 非アルコール性脂肪性肝疾患, Middle Aged, Fibrosis, age, Diabetes Mellitus, Type 2, 非アルコール性脂肪性肝炎, liver-related events
Abstract

Older age, type 2 diabetes mellitus (T2DM), and obesity are known risk factors for liver-related events (LREs). We investigated the impacts of T2DM and obesity on LRE according to age in Japanese patients with non-alcoholic fatty liver disease (NAFLD).We performed a subanalysis of a retrospective cohort study (CLIONE in Asia), including 1395 patients with biopsy-proven NAFLD. The median follow-up was 4.6 years.The median age was 57 years, and 36.2% had T2DM. The median body mass index (BMI) was 27.4, and 28.5% were severely obese (BMI ≥ 30). During follow-up, 37 patients developed hepatocellular carcinoma (HCC), and 58 patients developed LRE. In patients younger than 65 years, advanced fibrosis (hazard ratio [HR] 7.69, P 0.001) and T2DM (HR 3.37, P = 0.017) were HCC risk factors, and advanced fibrosis (HR 9.40, P 0.001) and T2DM (HR 2.51, P = 0.016) were LRE risk factors. In patients 65 years and older, advanced fibrosis (HR 4.24, P = 0.010) and obesity (HR 4.60, P = 0.006) were HCC risk factors, and advanced fibrosis (HR 4.22, P = 0.002) and obesity (HR 4.22, P = 0.002) were LRE risk factors.Type 2 diabetes mellitus and obesity contributed to LRE in younger and older patients, respectively, along with advanced fibrosis. Therefore, controlling T2DM in patients younger than 65 years and controlling weight in patients 65 years and older could prevent LRE. The development of age-dependent screening and management strategies is necessary for patients with NAFLD.

Published
2022
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7. Serum levels of type IV collagen 7S can predict liver-related mortality and events as well as advanced fibrosis: a multi-center study

Author

Ishiba, Hiroshi, primary, Sumida, Yoshio, additional, Kamada, Yoshihiro, additional, Fujii, Hideki, additional, Iwaki, Michihiro, additional, Hayashi, Hideki, additional, Toyoda, Hidenori, additional, Oeda, Satoshi, additional, Hyogo, Hideyuki, additional, Kawanaka, Miwa, additional, Morishita, Asahiro, additional, Munekage, Kensuke, additional, Kawata, Kazuhito, additional, Tsutsumi, Tsubasa, additional, Sawada, Koji, additional, Maeshiro, Tatsuji, additional, Tobita, Hiroshi, additional, Yoshida, Yuichi, additional, Naito, Masafumi, additional, Araraki, Shingo, additional, Kawaguchi, Takumi, additional, Noritake, Hiedenao, additional, Ono, Masafumi, additional, Masaki, Tsutomu, additional, Yasuda, Satoshi, additional, Tomita, Eiichi, additional, Yoneda, Masato, additional, Tokushige, Akihiro, additional, Takahashi, Hirokazu, additional, Ueda, Shinichiro, additional, Nakajima, Atsushi, additional, and Okanoue, Takeshi, additional

Published
2023
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8. A multicenter, retrospective, cohort study shows platelet counts predict HCC development in patients with NAFLD

Author

Fujii, Hideki, primary, Fujii, Makoto, additional, Iwaki, Michihiro, additional, Hayashi, Hideki, additional, Toyoda, Hidenori, additional, Oeda, Satoshi, additional, Hyogo, Hideyuki, additional, Kawanaka, Miwa, additional, Morishita, Asahiro, additional, Munekage, Kensuke, additional, Kawata, Kazuhito, additional, Tsutsumi, Tsubasa, additional, Sawada, Koji, additional, Maeshiro, Tatsuji, additional, Tobita, Hiroshi, additional, Yoshida, Yuichi, additional, Naito, Masafumi, additional, Araki, Asuka, additional, Arakaki, Shingo, additional, Kawaguchi, Takumi, additional, Noritake, Hidenao, additional, Ono, Masafumi, additional, Masaki, Tsutomu, additional, Yasuda, Satoshi, additional, Tomita, Eiichi, additional, Yoneda, Masato, additional, Kawada, Norifumi, additional, Tokushige, Akihiro, additional, Kamada, Yoshihiro, additional, Takahashi, Hirokazu, additional, Ueda, Shinichiro, additional, Aishima, Shinichi, additional, Sumida, Yoshio, additional, Nakajima, Atsushi, additional, and Okanoue, Takeshi, additional

Published
2023
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9. Association of serum albumin levels and long-term prognosis in patients with biopsy- confirmed nonalcoholic fatty liver disease

Author

Takahashi, Hirokazu, primary, Kawanaka, Miwa, additional, Fujii, Hideki, additional, Iwaki, Michihiro, additional, Hayashi, Hideki, additional, Toyoda, Hidenori, additional, Oeda, Satoshi, additional, Hyogo, Hideyuki, additional, Morishita, Asahiro, additional, Munekage, Kensuke, additional, Kawata, Kazuhito, additional, Tsutsumi, Tsubasa, additional, Sawada, Koji, additional, Maeshiro, Tatsuji, additional, Tobita, Hiroshi, additional, Yoshida, Yuichi, additional, Naito, Masafumi, additional, Araki, Asuka, additional, Arakaki, Shingo, additional, Kawaguch, Takumi, additional, Noritake, Hidenao, additional, Ono, Masafumi, additional, Masaki, Tsutomu, additional, Yasuda, Satoshi, additional, Tomita, Eiichi, additional, Yoneda, Masato, additional, Tokushige, Akihiro, additional, Kamada, Yoshihiro, additional, Ueda, Shinichiro, additional, Aishima, Shinichi, additional, Sumida, Yoshio, additional, Nakajima, Atsushi, additional, and Okanoue, Takeshi, additional

Published
2022
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10. Identification of clinical phenotypes associated with poor prognosis in patients with nonalcoholic fatty liver disease via unsupervised machine learning.

Author

Ito, Takanori, Morooka, Hikaru, Takahashi, Hirokazu, Fujii, Hideki, Iwaki, Michihiro, Hayashi, Hideki, Toyoda, Hidenori, Oeda, Satoshi, Hyogo, Hideyuki, Kawanaka, Miwa, Morishita, Asahiro, Munekage, Kensuke, Kawata, Kazuhito, Tsutsumi, Tsubasa, Sawada, Koji, Maeshiro, Tatsuji, Tobita, Hiroshi, Yoshida, Yuichi, Naito, Masafumi, and Araki, Asuka

Subjects
FATTY liver, NON-alcoholic fatty liver disease, MACHINE learning, GAUSSIAN mixture models, BODY mass index, MEDIAN (Mathematics)
Abstract

Background and Aims: Both fibrosis status and body weight are important for assessing prognosis in nonalcoholic fatty liver disease (NAFLD). The aim of this study was to identify population clusters for specific clinical outcomes based on fibrosis‐4 (FIB‐4) index and body mass index (BMI) using an unsupervised machine learning method. Methods: We conducted a multicenter study of 1335 biopsy‐proven NAFLD patients from Japan. Using the Gaussian mixture model to divide the cohort into clusters based on FIB‐4 index and BMI, we investigated prognosis for these clusters. Results: The cohort consisted of 223 cases (16.0%) with advanced fibrosis (F3–4) as assessed from liver biopsy. Median values of BMI and FIB‐4 index were 27.3 kg/m2 and 1.67. The patients were divided into four clusters by Bayesian information criterion, and all‐cause mortality was highest in cluster d, followed by cluster b (P = 0.001). Regarding the characteristics of each cluster, clusters d and b presented a high FIB‐4 index (median 5.23 and 2.23), cluster a presented the lowest FIB‐4 index (median 0.78), and cluster c was associated with moderate FIB‐4 level (median 1.30) and highest BMI (median 34.3 kg/m2). Clusters a and c had lower mortality rates than clusters b and d. However, all‐cause of death in clusters a and c was unrelated to liver disease. Conclusions: Our clustering approach found that the FIB‐4 index is an important predictor of mortality in NAFLD patients regardless of BMI. Additionally, non‐liver‐related diseases were identified as the causes of death in NAFLD patients with low FIB‐4 index. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Noninvasive tests predict liver‐related events and mortality in patients with nonalcoholic fatty liver disease: sub‐analysis of the CLIONE‐Asia study.

Author

Ishiba, Hiroshi, Sumida, Yoshio, Kamada, Yoshihiro, Fujii, Hideki, Iwaki, Michihiro, Hayashi, Hideki, Toyoda, Hidenori, Oeda, Satoshi, Hyogo, Hideyuki, Kawanaka, Miwa, Morishita, Asahiro, Munekage, Kensuke, Kawata, Kazuhito, Tsutsumi, Tsubasa, Sawada, Koji, Maeshiro, Tatsuji, Tobita, Hiroshi, Yoshida, Yuichi, Naito, Masafumi, and Araki, Asuka

Subjects
NON-alcoholic fatty liver disease, FATTY liver, LIVER biopsy, JAPANESE people, REFERENCE values
Abstract

Background and Aims: Noninvasive tests (NITs) have prognostic potential, but whether NITs are comparable with liver biopsy is unclear. This study aimed to examine the prognostic accuracy of NITs for liver‐related mortality (LRM) and events (LREs) in patients with biopsy‐proven nonalcoholic fatty liver disease (NAFLD). Methods: We investigated 1313 patients with NAFLD. Patients were assigned to low‐risk, indeterminate‐risk, and high‐risk groups using conventional cutoff values of each FIB‐4 and NAFLD fibrosis score (NFS) and to stage 0–2 and stage 3–4 groups using the fibrosis stage. Survival and Cox regression analyses of the prognostic potential of NITs for LRM/LREs were conducted. Results: During a median follow‐up of 4.5 years, regarding to FIB‐4, the incidence rate (/1000 person‐years) in the low risk was zero for LRM and 0.5 for LREs. In contrast, the rate in stage 0–2 was 1.3 for LRM and 2.8 for LRE. The adjusted hazard ratios (aHRs) for LREs in the high risk compared with the low risk were 32.85 (P < 0.01). The aHRs in stage 3–4 compared with stage 0–2 were 2.68 (P = 0.02) for LREs and 2.26 (P = 0.582) for LRM. In the same fibrosis stage, the incidence of LRM/LREs was more frequent with a higher risk stratification. The same trend was observed for NFS. Conclusions: NITs accurately predict LRM and LREs as well as a liver biopsy in Japanese patients with NAFLD. Patients in the low risk may not require close follow‐up for at least 5 years. The simple NITs could be an acceptable alternative method to performing a liver biopsy for the prognosis of NAFLD. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Multicenter, retrospective, cohort study shows platelet counts predict hepatocellular carcinoma development in patients with nonalcoholic fatty liver disease.

Author

Fujii, Hideki, Fujii, Makoto, Iwaki, Michihiro, Hayashi, Hideki, Toyoda, Hidenori, Oeda, Satoshi, Hyogo, Hideyuki, Kawanaka, Miwa, Morishita, Asahiro, Munekage, Kensuke, Kawata, Kazuhito, Tsutsumi, Tsubasa, Sawada, Koji, Maeshiro, Tatsuji, Tobita, Hiroshi, Yoshida, Yuichi, Naito, Masafumi, Araki, Asuka, Arakaki, Shingo, and Kawaguchi, Takumi

Subjects
NON-alcoholic fatty liver disease, FATTY liver, PLATELET count, HEPATOCELLULAR carcinoma, PROGNOSIS, COHORT analysis
Abstract

Aim: Impacts of platelet counts at the time of liver biopsy on hepatocellular carcinoma (HCC) development in patients with nonalcoholic fatty liver disease (NAFLD) remain unknown. The aim of this study was to investigate the prognostic value of platelet counts in patients with biopsy‐confirmed NAFLD using data from a multicenter study. Methods: One thousand three hundred ninety‐eight patients were included in this subanalysis of the CLIONE (Clinical Outcome Nonalcoholic Fatty Liver Disease) in Asia study. Liver biopsy specimens were pathologically diagnosed, and histologically scored using the NASH Clinical Research Network system. Demographic, clinical, laboratory, and pathological data were collected. Results: During a median follow‐up period of 4.6 years (range, 0.3–21.6 years), which corresponds to 8874 person‐years, 37 patients developed HCC. Using a cut‐off baseline platelet count of 192 × 109/L, the lower platelet group had a higher HCC rate than the higher platelet group (6.7% vs. 0.4%; p < 0.001). This cut‐off value significantly stratified the event‐free rate for HCC. Lower platelet counts were associated with an increased risk of HCC development. Relative to patients with platelet counts of 192 × 109/L, patients with platelet counts of 100 × 109/L had an unadjusted hazard ratio (HR) for HCC development of 7.37 (95% confidence interval [CI], 3.81–14.2) and an adjusted HR of 11.2 (95% CI, 3.81–32.7; p < 0.001), adjusting for age, sex, NASH, and diabetes. Conclusions: Baseline platelet counts of 192 × 109/L and lower are associated with a higher risk of developing HCC in patients with biopsy‐confirmed NAFLD and require active surveillance. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Association of Serum Albumin Levels and Long-Term Prognosis in Patients with Biopsy-Confirmed Nonalcoholic Fatty Liver Disease.

Author

Takahashi, Hirokazu, Kawanaka, Miwa, Fujii, Hideki, Iwaki, Michihiro, Hayashi, Hideki, Toyoda, Hidenori, Oeda, Satoshi, Hyogo, Hideyuki, Morishita, Asahiro, Munekage, Kensuke, Kawata, Kazuhito, Tsutsumi, Tsubasa, Sawada, Koji, Maeshiro, Tatsuji, Tobita, Hiroshi, Yoshida, Yuichi, Naito, Masafumi, Araki, Asuka, Arakaki, Shingo, and Kawaguchi, Takumi

Abstract

The relationship between baseline serum albumin level and long-term prognosis of patients with nonalcoholic fatty liver disease (NAFLD) remains unknown. This is a sub-analysis of the CLIONE (Clinical Outcome Nonalcoholic Fatty Liver Disease) study. The main outcomes were: death or orthotopic liver transplantation (OLT), liver-related death, and liver-related events (hepatocellular carcinoma [HCC], decompensated cirrhosis, and gastroesophageal varices/bleeding). 1383 Japanese patients with biopsy-confirmed NAFLD were analyzed. They were divided into 3 groups based on serum albumin: high (>4.0 g/dL), intermediate (3.5–4.0 g/dL), and low (<3.5 g/dL). Unadjusted hazard ratio [HR] of the intermediate albumin group, compared with the high albumin group, were 3.6 for death or OLT, 11.2 for liver-related death, 4.6 for HCC, 8.2 for decompensated cirrhosis, and 6.2 for gastroesophageal varices (all risks were statistically significant). After adjusting confounding factors, albumin remained significantly associated with death or OLT (intermediate vs. high albumin group: HR 3.06, 95% confidence interval [CI] 1.59–5.91, p < 0.001; low vs. high albumin group: HR 22.9, 95% CI 8.21–63.9, p < 0.001). Among biopsy-confirmed NAFLD patients, those with intermediate or low serum albumin had a significantly higher risk of death or OLT than those with high serum albumin. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Spontaneous regression of lung metastases after transarterial chemoembolization for hepatocellular carcinoma

Author

Kakuta, Naoko, primary, Yasumoto, Taku, additional, Yoshida, Yuichi, additional, Tsuda, Manabu, additional, Miyazaki, Akito, additional, Miyamoto, Satoshi, additional, Inada, Reiko, additional, Yorifuji, Hideki, additional, Higami, Yuichi, additional, Tetsumoto, Satoshi, additional, Miyazaki, Masaki, additional, Katada, Yoshinori, additional, and Naito, Masafumi, additional

Published
2021
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17. SAT-448 - Serum levels of type IV collagen 7S can predict liver-related mortality and events as well as advanced fibrosis: a multi-center study

Author

Ishiba, Hiroshi, Sumida, Yoshio, Kamada, Yoshihiro, Fujii, Hideki, Iwaki, Michihiro, Hayashi, Hideki, Toyoda, Hidenori, Oeda, Satoshi, Hyogo, Hideyuki, Kawanaka, Miwa, Morishita, Asahiro, Munekage, Kensuke, Kawata, Kazuhito, Tsutsumi, Tsubasa, Sawada, Koji, Maeshiro, Tatsuji, Tobita, Hiroshi, Yoshida, Yuichi, Naito, Masafumi, Araraki, Shingo, Kawaguchi, Takumi, Noritake, Hiedenao, Ono, Masafumi, Masaki, Tsutomu, Yasuda, Satoshi, Tomita, Eiichi, Yoneda, Masato, Tokushige, Akihiro, Takahashi, Hirokazu, Ueda, Shinichiro, Nakajima, Atsushi, and Okanoue, Takeshi

Published
2023
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22. The significance of interferon and ribavirin combination therapy followed by interferon monotherapy for patients with chronic hepatitis C in Japan

Author

Hiramatsu, Naoki, Kasahara, Akinori, Nakanishi, Fumihiko, Toyama, Takashi, Tsujii, Masahiko, Tsuji, Shingo, Kanto, Tatsuya, Takehara, Tetsuo, Kato, Michio, Yoshihara, Harumasa, Naito, Masafumi, Katayama, Kazuhiro, Hijioka, Taizo, Hagiwara, Hideki, Kubota, Shinji, Oshita, Masahide, Meren, Haruya, Masuzawa, Manabu, Haruna, Yoshimichi, Mita, Eiji, Suzuki, Kunio, and Hayashi, Norio

Published
2004
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33. Baseline quasispecies selection and novel mutations contribute to emerging resistance-associated substitutions in hepatitis C virus after direct-acting antiviral treatment

Author

Kai, Yugo, primary, Hikita, Hayato, additional, Morishita, Naoki, additional, Murai, Kazuhiro, additional, Nakabori, Tasuku, additional, Iio, Sadaharu, additional, Hagiwara, Hideki, additional, Imai, Yasuharu, additional, Tamura, Shinji, additional, Tsutsui, Syusaku, additional, Naito, Masafumi, additional, Nishiuchi, Meiko, additional, Kondo, Yasuteru, additional, Kato, Takanobu, additional, Suemizu, Hiroshi, additional, Yamada, Ryoko, additional, Oze, Tsugiko, additional, Yakushijin, Takayuki, additional, Hiramatsu, Naoki, additional, Sakamori, Ryotaro, additional, Tatsumi, Tomohide, additional, and Takehara, Tetsuo, additional

Published
2017
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34. A case of ferroportin disease B complicated with hepatocellular carcinoma

Author

Hibino, Chihiro, primary, Naito, Masafumi, additional, Kawasaki, Yosuke, additional, Tokuda, Takaaki, additional, Sato, Yu, additional, Matsushita, Megumi, additional, Kusakabe, Akira, additional, Sakai, Ayako, additional, Tatsumi, Yasuaki, additional, Kato, Koichi, additional, Kato, Ayako, additional, Kasugai, Tsutomu, additional, and Ito, Toshifumi, additional

Published
2017
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35. Clinical characteristics of hospitalized acute pancreatitis patients in our hospital

Author

Kawasaki, Yosuke, primary, Tokuda, Takaaki, additional, Sato, Yu, additional, Matsushita, Megumi, additional, Sakai, Ayako, additional, Kusakabe, Akira, additional, Kato, Mina, additional, Hibino, Chihiro, additional, Saiki, Hirotsugu, additional, Tokuda, Yuki, additional, Ishimi, Aya, additional, Kawai, Tomoyo, additional, Hamano, Mina, additional, Chiba, Miho, additional, Maeda, Kosaku, additional, Yamamoto, Katsumi, additional, Naito, Masafumi, additional, and Ito, Toshifumi, additional

Published
2016
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36. A case of chronic pancreatitis with difficult control of persistent pancreatic ascites

Author

Sato, Yu, primary, Kawasaki, Yosuke, additional, Tokuda, Takaaki, additional, Matsushita, Megumi, additional, Kusakabe, Akira, additional, Sakai, Ayako, additional, Saiki, Hirotsugu, additional, Kato, Mina, additional, Hibino, Chihiro, additional, Tokuda, Yuki, additional, Ishimi, Aya, additional, Kawai, Tomoyo, additional, Hamano, Mina, additional, Chiba, Miho, additional, Maeda, Kosaku, additional, Yamamoto, Katsumi, additional, Naito, Masafumi, additional, and Ito, Toshifumi, additional

Published
2016
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38. Safety and short-term outcomes of endoscopic submucosal dissection for early gastric cancer in elderly patients

Author

Kato, Minoru, additional, Michida, Tomoki, additional, Kusakabe, Akira, additional, Sakai, Ayako, additional, Hibino, Chihiro, additional, Kato, Mina, additional, Tokuda, Yuki, additional, Kawai, Tomoyo, additional, Hamano, Mina, additional, Chiba, Miho, additional, Maeda, Kosaku, additional, Yamamoto, Katsumi, additional, Naito, Masafumi, additional, and Ito, Toshifumi, additional

Published
2016
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39. Density analysis of hepatitis C virus particle population in the circulation of infected hosts: implications for virus neutralization or persistence

Author

Mita Eiji, Tatsuya Kanto, Kasahara Akinori, Tetsuo Takehara, Naito Masafumi, Fusamoto Hideyuki, Hayashi Norio, Kamada Takenobu, and Hagiwara Hideki

Subjects
Adult, Male, Adolescent, viruses, Hepatitis C virus, Population, Immunoglobulins, Hepacivirus, medicine.disease_cause, Liver disease, Immune system, medicine, Humans, Centrifugation, education, Aged, education.field_of_study, Hepatology, biology, Virion, Middle Aged, medicine.disease, Hepatitis C, Precipitin Tests, Virology, Reverse transcriptase, Immune complex, Antibodies, Anti-Idiotypic, Acute Disease, Chronic Disease, biology.protein, Female, Antibody
Abstract

Hepatitis C virus has a low buoyant density in sucrose, but high-density particles are often observed in hepatitis C virus infection. To investigate the characteristics of circulating hepatitis C virus particles and their association with liver disease progression, we examined sera from two histologically normal hepatitis C virus carriers, 20 chronic hepatitis patients and five acute hepatitis C patients. The supernatants obtained after immunoprecipitation with anti-immunoglobulins antibody were subjected to sucrose equilibrium centrifugation. HCV-RNA positive fractions separated after the treatments were further examined for immunoprecipitation with anti-core hepatitis C virus antibody. We separated hepatitis C virus particle populations according to the density difference on 35% sucrose with centrifugation. The proportions of high and low density particles in hepatitis C virus populations were determined by means of competitive reverse transcription and polymerase chain reaction. Circulating hepatitis C virus particles in chronically infected patients could be separated into two populations: those immunoglobulin-bound with high densities and -unbound with low densities. Patients with severe liver inflammation had high-density hepatitis C virus that did not precipitate with anti-immunoglobulins but with anti-core hepatitis C virus antibodies. Thus, hepatitis C virus particle populations consist of low-density virions and high-density immune complexes and/or nucleocapsids. Among the chronic hepatitis patients, the dominant population shifted from low-density to high-density particles with the progression of liver disease. In acute hepatitis patients, this density shift was observed with alanine aminotransferase normalizations. Therefore, the major hepatitis C virus populations change from virion to immune complex and/or nucleocapsid with the progression of liver disease or inflammation.

Published
1995
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44. 2 救命救急センターの現状と課題 : 他圏域に患者を出さない!(シンポジウム 救命救急センターの現状と課題 : 効率的な運用を目指して, 第660回新潟医学会)

Author

江部, 克也, 内藤, 万砂文, 小林, 和紀, Ebe, Katsuya, Naito, Masafumi, Kobayashi, Kazuki, 江部, 克也, 内藤, 万砂文, 小林, 和紀, Ebe, Katsuya, Naito, Masafumi, and Kobayashi, Kazuki

Abstract

長岡赤十字病院救命救急センターは, 魚沼から中越地区の, 医療の最後の砦として, 救急患者を他圏域に出さないことを目標にしている. 救命センターの効率化を図るため, (1)長岡救急懇談会の立ち上げ, (2)一部の三次救急患者も含めた病院輪番制, (3)休日・夜間診療所の長岡市による立ち上げ, などを進めてきた. 他病院・他施設との話し合いと連携により維持されるものであるが, 今後はさらに広範な連携を模索していきたい.

Published
2012

45. Tu1288 Prospective Study of Management of Perforation Caused by Endoscopic Submucosal Dissection (ESD) for Early Gastric Cancer (EGC)

Author

Michida, Tomoki, primary, Kita, Hisaaki, additional, Kanno, Tomoyo, additional, Takeda, Risato, additional, Murai, Kazuhiro, additional, Shiode, Yuto, additional, Kai, Yugo, additional, Matsumura, Yuki, additional, Jo, Hisashi, additional, Nakada, Yuki, additional, Chiba, Miho, additional, Maeda, Kosaku, additional, Naito, Masafumi, additional, Ito, Toshifumi, additional, and Yoshio, Toshiyuki, additional

Published
2013
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46. Sa1573 Endoscopic Submucosal Dissection (ESD) -Prospective Study for the Expanded Indication- for Undifferentiated Early Gastric Cancer (Ud-EGC)

Author

Takeda, Risato, primary, Michida, Tomoki, additional, Murai, Kazuhiro, additional, Shiode, Yuto, additional, Jo, Hisashi, additional, Kai, Yugo, additional, Matsumura, Yuki, additional, Morita, Rie, additional, Kita, Hisaaki, additional, Saito, Tamiko, additional, Kanno, Tomoyo, additional, Nakada, Yuki, additional, Chiba, Miho, additional, Maeda, Kosaku, additional, Naito, Masafumi, additional, and Ito, Toshifumi, additional

Published
2013
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47. A case of HCC occurred 5 years and 17 years after sustained virological response of interferon therapy for chronic hepatitis C

Author

Kato, Minoru, primary, Naito, Masafumi, additional, Kita, Hisaaki, additional, Kato, Mina, additional, Hibino, Chihiro, additional, Shiode, Yuto, additional, Murai, Kazuhiro, additional, Kai, Yugo, additional, Jo, Hisashi, additional, Matumura, Yuki, additional, Takeda, Risato, additional, Kanno, Tomoyo, additional, Saito, Tamiko, additional, Nakada, Yuki, additional, Chiba, Miho, additional, Maeda, Kosaku, additional, Michida, Tomoki, additional, and Ito, Toshifumi, additional

Published
2013
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48. Diuretics aggravate zinc deficiency in patients with liver cirrhosis by increasing zinc excretion in urine

Author

Chiba, Miho, primary, Katayama, Kazuhiro, additional, Takeda, Risato, additional, Morita, Rie, additional, Iwahashi, Kiyoshi, additional, Onishi, Yoshiki, additional, Kita, Hisaaki, additional, Nishio, Akira, additional, Kanno, Tomoyo, additional, Saito, Tamiko, additional, Maeda, Kosaku, additional, Naito, Masafumi, additional, Michida, Tomoki, additional, and Ito, Toshifumi, additional

Published
2012
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49. Mo1251 Clinical Characteristics and Management of Delayed Perforation Occurring After Endoscopic Submucosal Dissection for Early Gastric Cancer

Author

Kita, Hisaaki, primary, Michida, Tomoki, additional, Murai, Kazuhiro, additional, Shiode, Yuto, additional, Jo, Hisashi, additional, Kai, Yugo, additional, Matsumura, Yuki, additional, Morita, Rie, additional, Takeda, Risato, additional, Saito, Tamiko, additional, Kanno, Tomoyo, additional, Nakada, Yuki, additional, Chiba, Miho, additional, Maeda, Kosaku, additional, Naito, Masafumi, additional, and Ito, Toshifumi, additional

Published
2012
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