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Background: Rosai-Dorfman disease (RDD) is a rare non-Langerhans cell histiocytosis characterized by massive lymphadenopathy and systemic extranodal lesions. Case presentation: We present a case of 28-year-old female who presented with recurrent blurred vision in her right eye for 3 months. Her left eye had been blinded and atrophied a decade prior. She subsequently developed a headache, fever, and impaired mental status. Cranial MRI indicated hypertrophic pachymeningitis (HP), and 18F-FDG PET/CT revealed significant FDG uptake in the left dura mater. Autoimmune testing revealed elevated anti-nuclear, anti-SS-A, and anti-SS-B antibodies. Incisional biopsy of the atrophic eyeball revealed RDD with marked polyclonal plasmacytosis. The patient was diagnosed with RDD accompanied by multisystem involvement, including Sjögren’s syndrome (SS), panuveitis, and HP. Treatment with methylprednisolone over several weeks resulted in significant improvement. Conclusions: This is the first reported case of RDD presenting with SS in combination with panuveitis and HP. Although RDD is rarely diagnosed in young patients, interdisciplinary collaboration is essential to prevent delayed diagnosis.

Hydrogen isotope separation within the metal–organic framework material known as Cu(I)-MFU-4l is investigated using a combination of breakthrough analysis, equilibrium measurements, and infrared sp...

Introduction: Inadequate myocardial coronary perfusion is a major cause of cardiac dysfunction in several clinical settings including congenital heart disease and cardiopulmonary bypass surgery (CPB). Blood flow to the myocardium (i.e. coronary perfusion) is primarily controlled by the coronary microvasculature (vessels < 500 μm) which plays a key part in coronary perfusion autoregulation. Until recently, direct quantitative coronary perfusion assessment had been infeasible due to limitations in spatial and/or temporal resolution of clinical imaging modalities. The study objective is to assess if ultrafast ultrasound-mediated power Doppler (PD) can approximate changes in myocardial perfusion in humans. Methods: We used a 6.9 MHz linear array probe connected to a programmable ultrafast ultrasound scanner (Verasonics Vantage®). We included 7 neonates with transposition of the great arteries (TGA) and acquired epicardial ultrafast acquisitions immediately before and after CPB (arterial switch operation) via open chest. The acquisitions were acquired at 2000 fps (PRF=10000Hz, 5 sources). Tissue clutter was separated from coronary signals with a sliding spatiotemporal filter. PD was measured as a representative of blood volume that scales with hematocrit. Fractional moving blood volume (FMBV) was calculated to normalize the PD signal: mean PD divided by the PD of the ventricular blood pool, a region with 100% vascular amplitude. Results and Conclusions: The FMBV post-operatively increased by a factor of two compared to pre-operative assessment, a reflection of hyperemia. These values returned to baseline on repeat assessment prior to discharge. Our findings suggest that ultrafast PD is a reliable tool in approximating changes in myocardial perfusion in the operating room and beyond. Thus, ultrafast power Doppler can be utilized to quantitatively assess the impact of CPB on coronary perfusion in humans.

The auxiliary external power Qinfang 2P70 of Fangjiashan NPP need to be shutdown, which makes one way the external power unavailable, thus affecting the safety level of the plant. In this paper, Through the internal event level PSA model, internal event LERF model, internal fire model and internal water flooded model, during Fangjiashan at power, 2P70 shut down caused one way the external power unavailable, gives the safety assessment results, And put forward the close attention of the important equipment such as the main power grid and the diesel engine. The test and maintenance of the diesel engine and the SEC/RRI heat exchanger are prohibited. The risk of the unit is managed and controlled by a series of other measures. The risk monitor is used to supervise the unit in real time. Finally, the application risk monitor of the power plant is discussed. The necessity and the PSA method to evaluate the possibility of auxiliary transformer shutdown to generalize to generating units.

Identification and separation of microseismic (MS) events and blasting signals is typically a challenging issue. In particular, the extraction of features from large amounts of data using shallow neural networks is inefficient and not always complete. To address this, the use of a deep belief network model to identify MS events and blasting signals during construction processes is proposed. The aim is to take advantage of the strong learning and feature extraction abilities of such models. Using data recorded during the construction of the Jinping Hydropower Station II in China, nine typical source parameters are selected to use as characteristic parameters. This is accomplished by comparing and analyzing the differences and probability density distribution ranges of the different source parameters associated with MS and blasting events. The model uses the data collected for the source parameters to learn, train, and test. A classification accuracy of 94.4% was thus achieved, which is superior to that obtained using traditional support vector machine and Fisher classifiers. The results also show that the method has other advantages compared to the other methods: false positive rates are low, the characteristic parameters are easy to acquire, and the calculation speed is fast. It is thus an effective method of identifying MS and blasting events when using MS monitoring techniques.

Additional file 1: Table S1. Information and abbreviations of DLSM algorithms.

Salinity-stressed plants of salinity sensitive ('Qx096') and tolerant ('Qx097') chrysanthemum cultivar were treated with a range of concentrations of spermidine (Spd). Plant performance, as indicated by various parameters associated with growth, was improved by the treatment, as was the tissue content of soluble protein and proline. The extent of both Na(+) accumulation and K(+) loss was reduced. Activity levels of the stress-related enzymes SOD, POD, APX and CAT were significantly increased and the production of malondialdehyde (MDA) decreased. The suggestion was that treatment with 1.5 mM Spd would be an effective means alleviating salinity-stress induced injury through its positive effect on photosynthetic efficiency, reactive oxygen species scavenging ability and the control of ionic balance and osmotic potential. Its protective capacity was more apparent in 'Qx096' than in 'Qx097'.

Pore structure of carbonate reservoirs is complex and multimodal. In order to characterize the pore structure of complex carbonate, a modified multimodal Thomeer pore size distribution (PSD) function was developed, which was based on the multimodal Gaussian density function and three controlling parameters including peak position, peak height and full width at half maximum (FWHM). The Expectation-Maximization algorithm for Gaussian mixture model was utilized to obtain three controlling parameters for the calculation of Thomeer parameters, namely the extrapolated displacement pressure, the percent bulk volume occupied by mercury at infinite capillary pressure and the pore geometrical factor. Three permeability models were proposed based on the Thomeer parameters and compared with the previous models. The results show that PSD curve of 55% samples need more than two Gaussian density function, which illustrates the multimodal characteristic. Thomeer parameters relate to the controlling parameters of Gaussian density function. The peak position moved toward larger capillary pressure with the increase of extrapolated displacement pressure and pore geometrical factor. The peak height has positive correlation with the percent bulk volume occupied by mercury at infinite capillary pressure and negative correlation with pore geometrical factor respectively. FWHM has positive correlation with pore geometrical factor. The extrapolated displacement pressure derived from the first Gaussian density function has a high correlation with permeability, which demonstrates that permeability is mainly controlled by the maximum pore throat radius. We found that when the sample has the percentage occupied by the first porous system larger enough than 21.64%, its permeability is dominated by the first porous system with the maximum pore throat radius; otherwise, it would be influenced by the second porous system. The comparative study shows that permeability models that has considered the influence of second porous system could improve the accuracy of permeability estimation for the complicated carbonate samples.

In the physical model experiment, the polymer is usually manufactured by means of distilled water and sewage. In this paper, it was found by scanning electron microscopy that Ca2+ and Mg2+ contained in the formulated water reacted with -COO in the polymer. A sharp drop in the viscosity capacity of the solution, And the effect of Mg2+ on the viscosity of the solution is about 1.2 to 1.5 times than Ca2+. Metal ions have a negative impact on the extraction of polymers., The polymer’s adaptability to three ply of oil layers is reduced. Under the condition of high extent of mineralization, the displacement characteristics of the high-efficiency, Viscosity and Salt-resisting polymer is better than middle-divided HPAM, and the enhanced oil recovery value is 3.13% higher than middle-point HPAM.

Box culverts are common small structures in highway engineering. According to domestic and foreign practical experience in recent years, component factory prefabrication combined with on-site assembly can effectively improve production efficiency and construction quality. It will become the main trend in the box culvert structure and gradually replace the traditional cast-in-place process. Based on the project of 03A design section of Daqing to Guangzhou Expressway, this paper expounds in detail the assembly process and key operation points of prefabricated components. It also compared with the traditional culvert construction technique, which demonstrates the superiority of prefabricated box culvert assembly technology.

Aryl alkynes containing strongly electron-withdrawing or strongly electron-donating substituents provide low yields in comparison to other aryl or alkyl substituted alkynes.

Linear iodoniums are widely used as arylating reagents. However, cyclic diaryl idodoniums are ignored despite their potential to initiate dual arylations, atom and step economically. In our current work, a three-component cascade reaction of cyclic diaryliodoniums, sodium azide, and alkynes has been successfully achieved under mild conditions, catalyzed by cheap copper species. The regioselectivity associated with unsymmetrical iodoniums was enhanced by installing two methyls ortho and para to the I(III) center. The reaction enables a rapid access to a variety of complex molecules, triazolophenanthridine derivatives.