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Your search keyword '"Nakagawa, Masayo"' showing total 25 results
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25 results on '"Nakagawa, Masayo"'

2. A case report of acquired reactive perforating collagenosis involving a patient with type 2 diabetes and end-stage kidney disease successfully treated with minocycline

Author

Katsuoka, Yoji, primary, Maruyama, Izumi, additional, Ono, Kaoru, additional, Kobayashi, Yoshiko, additional, Nakagawa, Masayo, additional, Sato, Mihoko, additional, Sasaki, Hiroaki, additional, Kobashi, Kazuya, additional, Tsuneyama, Shigeto, additional, Koyama, Makoto, additional, and Honda, Yusuke, additional

Published
2023
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10. Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2

Author

Nakagawa, Osamu, Arnold, Michael, Nakagawa, Masayo, Shelton, John M., Hamada, Hideaki, Kusano, Hajime, Harris, Thomas M., Childs, Geoffrey, Campbell, Kevin P., Richardson, James A., Nishino, Ichizo, and Olson, Eric N.

Subjects
Central core myopathy -- Diagnosis, Homeostasis -- Analysis, Rats -- Genetic aspects, Rats -- Physiological aspects, Rattus -- Genetic aspects, Rattus -- Physiological aspects, DNA microarrays, Biological sciences
Abstract

A microarray analysis of a myocyte enhancer factor 2 (MEF2) lacking mouse embryos is carried out, to find a novel MEF2-regulated gene encoding a muscle-specific protein kinase, known as serine arginine protein kinase (Srpk3). The results show that normal muscle growth and homeostasis require MEF2-dependent signaling by Srpk3.

Published
2005

11. Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling

Author

Nakagawa, Osamu, McFadden, David G., Nakagawa, Masayo, Yanagisawa, Hiromi, Hu, Tonghuan, Srivastava, Deepak, and Olson, Eric N.

Subjects
Genetic transcription -- Regulation, Genetic research -- Analysis, Gene expression -- Research, Science and technology
Abstract

The Hairy-related transcription-factor (HRT) genes encode three related basic helix-loop-helix transcription factors that show sequence similarity to the Hairy and Enhancer of split family of transcriptional repressors. HRT proteins are expressed in specific regions of the developing heart, vasculature, pharyngeal arches and somites, and the periodicity of their expression in somitic precursors mirrors that of Notch signaling-related molecules. In the present study, we show that the intracellular domain of the Notch1 receptor (Notch1 IC), which is constitutively active, up-regulates HRT2 expression in 10T 1/2 fibroblasts. Luciferase reporter assays using the regulatory regions of the mouse HRT genes revealed that transcription of all three genes is stimulated by Notch1 IC. The promoters of the HRT genes share homology in a binding site for Suppressor of Hairless [Su(H)], a transcriptional mediator of Notch signaling. A dominant-negative Su(H) mutant abolished Notch-activated HRT2 expression, and mutation of the conserved Su(H) consensus site in the HRT2 promoter attenuated transcriptional activation by Notch. Ectopic expression of HRT proteins also blocked activation of HRT2 expression by Notch1 IC through a mechanism requiring the basic region, but not the conserved carboxyl-terminal YQPW-TEVGAF motif of HRT2. These findings identify HRT genes as downstream targets for Notch signaling and reveal a negative autoregulatory loop whereby HRT proteins repress their own expression through interference with Notch signaling.

Published
2000

14. Nihon Nyugan Kenshin Gakkaishi (Journal of Japan Association of Breast Cancer Screening)

Author

Nakayama, Takashi, primary, Kotsuma, Yoshikazu, additional, Hiramatsu, Sawako, additional, Kanai, Nobuhiro, additional, Kanai, Mariko, additional, Fujiwara, Yasuhisa, additional, Akahori, Taiichiro, additional, Hara, Takahiko, additional, Sakamoto, Yasuo, additional, Yamamoto, Hitomi, additional, Nakagawa, Masayo, additional, Abe, Noriko, additional, Kotsuma, Yasuyuki, additional, and Nakajima, Tadashi, additional

Published
2007
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15. Aldosterone Induces Angiotensin-Converting-Enzyme Gene Expression in Cultured Neonatal Rat Cardiocytes

Author

Harada, Eisaku, primary, Yoshimura, Michihiro, additional, Yasue, Hirofumi, additional, Nakagawa, Osamu, additional, Nakagawa, Masayo, additional, Harada, Masaki, additional, Mizuno, Yuji, additional, Nakayama, Masafumi, additional, Shimasaki, Yukio, additional, Ito, Teruhiko, additional, Nakamura, Shota, additional, Kuwahara, Koichiro, additional, Saito, Yoshihiko, additional, Nakao, Kazuwa, additional, and Ogawa, Hisao, additional

Published
2001
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17. Ameliorated Glomerular Injury in Mice Overexpressing Brain Natriuretic Peptide with Renal Ablation

Author

KASAHARA, MASATO, primary, MUKOYAMA, MASASHI, additional, SUGAWARA, AKIRA, additional, MAKINO, HISASHI, additional, SUGANAMI, TAKAYOSHI, additional, OGAWA, YOSHIHIRO, additional, NAKAGAWA, MASAYO, additional, YAHATA, KENSEI, additional, GOTO, MASAHISA, additional, ISHIBASHI, RIEKO, additional, TAMURA, NAOHISA, additional, TANAKA, ISSEI, additional, and NAKAO, KAZUWA, additional

Published
2000
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20. ALTERED GENE EXPRESSION OF NATRIURETIC PEPTIDE RECEPTOR SUBTYPES IN THE KIDNEY OF STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE RATS

Author

Goto, Masahisa, primary, Itoh, Hiroshi, additional, Tanaka, Issei, additional, Suga, Shin‐ichi, additional, Ogawa, Yoshihiro, additional, Kishimoto, Ichiro, additional, Nakagawa, Masayo, additional, Sugawara, Akira, additional, Yoshimasa, Takaaki, additional, Mukoyama, Masashi, additional, and Nakao, Kazuwa, additional

Published
1995
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23. HRT1, HRT2,and HRT3:A New Subclass of bHLH Transcription Factors Marking Specific Cardiac, Somitic, and Pharyngeal Arch Segments

Author

Nakagawa, Osamu, Nakagawa, Masayo, Richardson, James A., Olson, Eric N., and Srivastava, Deepak

Abstract

Members of the Hairy/Enhancer of Split family of basic helix-loop-helix (bHLH) transcription factors are regulated by the Notch signaling pathway in vertebrate and Drosophilaembryos and control cell fates and establishment of sharp boundaries of gene expression. Here, we describe a new subclass of bHLH proteins, HRT1 (Hairy-related transcription factor 1), HRT2, and HRT3, that share high homology with the Hairy family of proteins yet have characteristics that are distinct from those of Hairy and other bHLH proteins. Each HRTgene was expressed in distinct cell types within numerous organs, particularly in those patterned along the anterior–posterior axis. HRT1and HRT2were expressed in atrial and ventricular precursors, respectively, and were also expressed in the cardiac outflow tract and aortic arch arteries. HRT1and HRT2transcripts were also detected in precursors of the pharyngeal arches and subsequently in the pharyngeal clefts. Within somitic precursors, HRT1and HRT3exhibited dynamic expression in the presomitic mesoderm, mirroring the expression of other components of Notch–Delta signaling pathways. The HRTgenes were expressed in other sites of epithelial–mesenchymal interactions, including the developing kidneys, brain, limb buds, and vasculature. The unique and complementary expression patterns of this novel subfamily of bHLH proteins suggest a previously unrecognized role for Hairy-related pathways in segmental patterning of the heart and pharyngeal arches, among other organs.

Published
1999
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