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26 results on '"Nakajima, Takehisa"'

16. Effects of lower alcohols on nanocomposite particles for inhalation prepared using O/W emulsion.

Author

Takeuchi, Issei, Kimura, Yukie, Nakajima, Takehisa, and Makino, Kimiko

Subjects
NANOCOMPOSITE materials, EMULSIONS, PARTICULATE matter, ALCOHOL, AQUEOUS solutions, LEUCINE
Abstract

BACKGROUND: Inhalable nanocomposite particles using O/W emulsions were studied. The effect of the composition of the dispersed phase on the nanoparticles in the nanocomposite particles was reported, however, the effect on the inhalation characteristics of nanocomposite particles has not been investigated. OBJECTIVE: The aim of this study was to study the effects of lower alcohols in the dispersed phase of O/W emulsions on inhalable nanocomposite particles. METHODS: Nanocomposite particles were prepared using a spray dryer from O/W emulsion. A mixed solution of dichloromethane and lower alcohols in which rifampicin (RFP) and poly(L-lactide-co-glycolide) were dissolved was used as a dispersed phase, and an aqueous solution in which arginine and leucine were dissolved was used as a continuous phase. RESULTS: We succeeded in preparing non-spherical nanocomposite particles with an average diameter of 9.01–10.91 μm. The results of the fine particle fraction (FPF) measurement showed that the higher the hydrophobicity of the lower alcohol mixed in the dispersed phase, the higher the FPF value. The FPF value of the nanocomposite particles was significantly increased by using ethanol and 1-propanol. CONCLUSIONS: The results were revealed that mixing 1-propanol with the dispersed phase increased the amount of RFP delivered to the lungs. [ABSTRACT FROM AUTHOR]

Published
2022
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22. Selective delivery of rifampicin incorporated into poly(dl-lactic-co-glycolic) acid microspheres after phagocytotic uptake by alveolar macrophages, and the killing effect against intracellular Mycobacterium bovis Calmette–Guérin

Author

Yoshida, Aya, primary, Matumoto, Makoto, additional, Hshizume, Hiroyuki, additional, Oba, Yoshiro, additional, Tomishige, Tatuo, additional, Inagawa, Hiroyuki, additional, Kohchi, Chie, additional, Hino, Mami, additional, Ito, Fuminori, additional, Tomoda, Keishiro, additional, Nakajima, Takehisa, additional, Makino, Kimiko, additional, Terada, Hiroshi, additional, Hori, Hitoshi, additional, and Soma, Gen-Ichiro, additional

Published
2006
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26. [Transdermal Delivery of NSAIDs].

Author

Nakajima T and Makino K

Subjects
Administration, Cutaneous, Humans, Permeability, Skin Absorption, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Anti-Inflammatory Agents, Non-Steroidal metabolism, Skin metabolism
Abstract

Skin has been studied as administration site of drug for its systemic effects, since systemic therapeutic agents can be delivered for long time with a controlled ratio, escaping from the first pass effect by liver by the transdermal delivery, which can decrease the dosage form. The low permeability of drug molecules through stratum corneum has been the limiting factor for developing transdermal delivery system of therapeutic agents. To enhance the permeability of drug molecules, many studies have been reported.

Published
2015

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