15 results on '"Nakajo, Shinobu"'
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2. Abstracts of selected papers presented at the 78th general meeting of the Japanese Society of Gastroenterology
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Kusano, Motoyasu, Sekiguchi, Toshikazu, Hanyu, Nobuyoshi, Aoki, Teruaki, Matsushima, Yasuhiro, Okamoto, Eizo, Takeda, Yasuo, Takeda, Ryoyu, Miyachi, Masahiko, Nimura, Yuji, Arai, Taidoh, Masuda, Jun, Tanaka, Masao, Ogawa, Yoshiaki, Ura, Kazuhide, Matsumoto, Teiji, Taniyama, K., Kurosawa, Susumu, Owyang, Chung, Baba, Hiroshi, Fujimura, Masaki, Hamada, Eiji, Shimada, Tadahito, Kabemura, Teppei, Chijiiwa, Yoshiharu, Sato, T., Koito, K., Matsuda, Hiroko, Kawasaki, Tsunehisa, Obara, Katsutoshi, Kasukawa, Reiji, Miyoshi, Hirofumi, Matsumoto, Akio, Yamamoto, Manabu, Ohmasa, Ryouji, Kokubu, Shigehiro, Shibata, Hisao, Tajiri, Takashi, Onda, Masahiko, Hashizume, Makoto, Sugimachi, Keizo, Kobayashi, Kenji, Shiozaki, Hitoshi, Fujisaki, Junko, Shimoda, Tadakazu, Hase, Satoshi, Tsukamoto, Yoshihisa, Atsumi, M., Konishi, H., Nakajo, Shinobu, Fujiyama, Yoshihide, Taruishi, Masaki, Ayabe, Tokiyoshi, Morise, Kimitomo, Yamaguchi, Takeo, Makiyama, Kazuya, Itsuno, Minoru, Matsui, T., Okabe, N., Okabe, Nobuo, Matsui, Toshiyuki, Sakatani, Arata, Koizumi, Koichi, Imai, Yutaka, Sugino, Yoshinori, Masaki, Tadahiko, Sawada, Toshio, Nishigami, Takashi, Satomi, Masamichi, Hatada, Yasumasa, Saito, Hiroshi, Kobayshi, Kiyonori, Katsumata, Tomoe, Sugimoto, Kenji, Itabashi, Tsukasa, Kitagawa, Motoji, Hayakawa, Tetsuo, Okazaki, Kazuichi, Yamamoto, Yasuro, Funakoshi, Akihiro, Miyasaka, Kyoko, Soejima, Kazuhiko, Kanda, Mikio, Sugiyama, Masanori, Kuroda, Akira, Inoue, Hisayuki, Bamba, Tadao, Hamanaka, Y., Suzuki, T., Suzuki, Mamoru, Hanyu, Fujio, Tamura, Katsuhiro, Nakase, Akira, Noguchi, M., Hiwatashi, N., Murata, Yuhji, Suzuki, Kazuo, Ohtani, Haruo, Watanabe, Yoshihisa, Zeniya, Mikio, Aizawa, Yoshio, Masumoto, T., Onji, M., Hamasaki, Keisuke, Nakata, Keisuke, Fukui, Hiroshi, Tsujii, Tadasu, Yamashiki, Masayoshi, Nishimura, Akira, Tsutsui, Hiroko, Mizoguchi, Yasuhiro, Kimura, Fumio, Miyazaki, Masaru, Kiyota, Keisuke, Inokuchi, Hideto, Yamamoto, Yoshihiro, Oka, Hiroshi, Horikoshi, Tsutomu, Sekiguchi, Toshikazu, Takayasu, H., Shirai, T., Hongo, Michio, Okuno, Yo, Okano, H., Aoyama, N., Ohsuki, Masao, Maeda, Kenji, Haruma, Ken, Sumii, Koji, Nakai, Yoshihide, Fukunaga, Mikihiko, Kaneko, Hiroshi, Morise, Kimitomo, Okumura, Toshikatsu, Uehara, Akira, Fukuda, Yoshihiro, Satomi, Masamichi, Joh, Takashi, Itoh, Makoto, Kitagawa, Yuko, Kitajima, Masaki, Iwao, Tadashi, Toyonaga, Atsushi, Nakamura, Masahiko, Oda, Masaya, Kawamura, Yukimitsu, Dohden, Kenji, Kamiyama, Yasuhiko, Matsuno, Seiki, Hirano, Morihisa, Otsuka, Sachio, Ito, Masahiro, Sekine, Ichiro, Ogihara, Tatsuo, Sato, Nobuhiro, Uehara, Akira, Namiki, Masayoshi, Sugiura, Nobuyuki, Ebara, Masaaki, Matsuo, Naoki, Uchida, Hideo, Okada, Shuichi, Okazaki, Nobuo, Tsujii, Hirohiko, Ohsuga, Toshiaki, Abe, M., Nagata, Y., Yamasaki, Susumu, Kosuge, Tomoo, Kitamoto, Mikiya, Nakanishi, Toshio, Ichikawa, Yuzo, Mizoguchi, Yasuhiro, Ohtake, Yoshio, Hirasawa, Hiroyuki, Sugihara, Junichi, Muto, Yasutoshi, Yasunaga, Mitsuru, Okita, Kiwamu, Ukida, Minoru, Tsuji, Takao, Isai, Hideya, Uchino, Junichi, Suzuki, Katsuhiko, Komatsu, Kanji, Ohtomo, Yumiko, Idezuki, Yasuo, Sakuramachi, Shunji, Kimura, Taizo, Kitano, Seigo, Sugimachi, Keizo, Moriyama, Masaaki, Yazaki, Yasuyuki, and Saito, Takashige
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- 1993
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3. Abstracts of selected papers presented at the 77th General Meeting of the Japanese Society of Gastroenterology: March 28–30, 1991, Tokyo, Japan
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Kijima, Hiroshi, Watanabe, Hidenobu, Tomatsu, Sei, Oi, Itaru, Nagaiwa, Jiro, Ariyama, Jo, Mitake, Masahiro, Naitoh, Yasuo, Ono, Yoshiki, Yokomizo, Seiji, Nakayama, Toshimichi, Sugimura, Fumiaki, Matsuo, Yutaka, Murayama, Isao, Tanaka, Takashi, Hanyu, Nobuyoshi, Aoki, Teruaki, Shiraha, Sei, Shiraha, Sei, Hiura, Akihito, Satake, Katsusuke, Suda, Koichi, Sakamoto, Yoshiya, Okazaki, Kazuichi, Kondo, Takaharu, Hayakawa, Tetsuo, Kanoh, Makoto, Kohashi, Etsu, Kataoka, Keisho, Kashima, Kei, Yokotani, Kunihiko, Yamada, Tadataka, Mieno, Hiroshi, Shirakawa, Toshio, Komatsu, Hirokazu, Oda, Masaya, Nakamura, Keiya, Aoike, Akira, Takagi, Yoji, Inoue, Yoshifumi, Kasahara, Hiroshi, Saitoh, Yoichi, Tashiro, T., Mashima, Y., Sasaki, Fumiaki, Uchino, Junichi, Haraguchi, Yoshikura, Kirita, Manabu, Iwasa, Masato, Ogoshi, Shohei, Sato, Nobuaki, Matsubara, Youichi, Kinouchi, Y., Hiwatashi, N., Chikamochi, Nobuo, Nakajo, Shinobu, Yoshida, Takashi, Muto, Yasutoshi, Suzuki, Kazutomo, Arakawa, Yasuyuki, Takahashi, Hiroaki, Noguchi, Takashi, Suzuki, Hiroshi, Okabe, Kazuhiko, Azuma, Megumu, Koizumi, Masaru, Kawaguchi, Shinya, Matsuno, Seiki, Tsuji, Shingo, Kawano, Sunao, Oda, Masaya, Nakamura, Masahiko, Nakamura, Hajime, Kobayashi, Kenzo, Kashiwagi, Hideyuki, Aoki, Teruaki, Nishikawa, Masahiro, and Suzuki, Takashi
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- 1992
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4. Abstracts of Selected Papers Presented at the 76th General Meeting of the Japanese Society of Gastroenterology
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Watanabe, Yasuyuki, Nakanishi, Toshi, Mori, Yoshio, Oto, Masao, Onji, Morikazu, Ohta, Yasuyuki, Kuroki, Tetsuo, Yamamoto, Sukeo, Iwasaki, Yoshiaki, Tsuji, Takao, Ikeda, Yusei, Toda, Gotaro, Saitoh, T., Asakura, H., Onishi, Saburo, Iwasaki, Shinji, Oda, M., Azuma, T., Ikeda, Takaaki, Hasumura, Yasushi, Usui, K., Ishii, H., Nakano, Hitoshi, Tanikawa, Kyuichi, Inoue, Kyoichi, Higuchi, Kiyohiro, Hasumura, Satoshi, Nagamori, Scishi, Okanoue, Takeshi, Morimoto, Michio, Koide, Norio, Tsuji, Takao, Hayashi, Norio, Sato, Nobuhiro, Ono, Shigeki, Moriyasu, Fuminori, Miyazaki, Kohji, Hisatsugu, Takeharu, Kawamura, Yasuhito, Nakanuma, Yasuni, Tarao, Kazuo, Shimizu, Akio, Nishida, Jiro, Oda, Masaya, Okabayashi, Yoshinori, Otsuki, Makoto, Hosotani, Ryo, Tobe, Takayoshi, Sumii, Kimura, Toshinari, Mutoh, Hiroyuki, Terano, Akira, Terashima, H., Yabana, T., Yakabe, Koji, Nakamura, Takashi, Yamada, Tadataka, Chiba, T., Fujita, T., Ikeda, Yoshitake, Kitajima, Masaki, Nakajo, Shinobu, Minemori, Kiyoharu, Nakanishi, Takashi, and Okuno, Masaru
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- 1992
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5. Abstracts of selected papers presented at the 30th Annual Meeting of the Japanese Society of Gastroenterology October 20–22, 1988 — Kagoshima, Japan
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Oda, Ichiro, Ogawa, Kaoru, Okada, Shuichi, Ueno, Keiichi, Itoh, Tohru, Horiguchi, Yuji, Kijima, Hiroshi, Inui, Kazuo, Koga, Akitoshi, Hamamoto, Tetsuro, Tsukada, Hideaki, Tamada, Takashi, Nakamura, Takahiko, Okanoue, T., Koike, Daisuke, Abe, Hirohiko, Miura, Tsutomu, Hashimoto, Shuji, Oda, M., Azuma, T., Nagata, Shigeyuki, Ishii, Hiromasa, Kawada, Norifumi, Mizoguchi, Yasuhiro, Yoshikawa, Yuji, Oka, Hiroshi, Ichida, Takafumi, Ichida, Fumihiro, Ueno, Takato, Tanikawa, Kyuichi, Kokudo, Norihiro, Kawasaki, Seiji, Onji, Morikazu, Miyaoka, Hiroaki, Yokosuka, Osamu, Omata, Masao, Ikeda, Hiroshi, Tsuji, Takao, Hayashi, Shigeki, Fujiwara, Kenji, Yasunaga, Mitsuru, Okita, Kiwamu, Takase, Koujirou, Tameda, Yukihiko, Ohnishi, Hiroo, Sugihara, Jun-ichi, Kojima, Hideo, Kamimura, Tomoteru, Tanaka, Eiji, Yoda, Hidetoshi, Kanno, Atsushi, Ohtsuki, Masao, Miyata, Yasuji, Koga, Shunichi, Unoura, Masashi, Tanaka, Nobuyoshi, Kodama, Takahiro, Nishimura, Hideo, Suzuki, Kazuyuki, Madarame, Takeo, Komatsu, Masafumi, Ookubo, Shunji, Nishiyama, Masataka, Saito, Shozo, Kumashiro, Ryukichi, Tanikawa, Kyuichi, Ikeda, Kenji, Kumada, Hiromitsu, Nishiguchi, Shuhei, Kuroki, Tetsuo, Yoshiba, Makoto, Takeuchi, Yukari, Morito, Takao, Kasukawa, Reiji, Takeda, Isao, Nakano, Satoshi, Matsumura, Kenzo, Imanari, Tomohiro, Lee, Shigeki, Fujita, Naotaka, Mine, Tetsuya, Sato, Eiichi, Suyama, Masafumi, Ariyama, Jo, Takahashi, Toshihisa, Hirano, Masanori, Hirai, Atsushi, Yamakawa, Tatsuo, Kamiya, Junichi, Nimura, Yuji, Yoshimoto, Hideo, Ikeda, Seiyo, Yamasuji, Tadashi, Saeki, Keizo, Itoh, Masaki, Kajiyama, Goro, Seki, Hideichi, Kimura, Ken, Nakamura, Hiroshi, Tsuchiya, Yukihiro, Omura, Ryosuke, Tanaka, Shinya, Shimakura, Katsuhide, Matsuda, Yoshiaki, Wakabayashi, Tokio, Morimoto, Hideo, Kamiya, Yasutaka, Okayama, Yasutaka, Kobayashl, Masao, Fujimoto, Sotaro, Yamaguchi, Atsumasa, Shibue, Tadashi, Akashi, Ryukichi, Hattori, Masahiro, Takehira, Yasunori, Tsugane, Yasutoshi, Tashiro, Yoshinori, Kuwayama, Hajime, Kon, Yoichi, Higuchi, Tsugio, Hirata, Nobuto, Kano, Tomoyuki, Kurimoto, Kumiko, Kubota, Y., Seki, T., Kamura, Yoshimine, Nakayama, Toshimichi, Yoshimura, Hitoshi, Yoshioka, Tetsuya, Akimoto, Kimihiko, Mine, Tetsuya, Sato, Eiichi, Ohnishi, Hirohide, Ogata, Etsuro, Igarashi, Atsushi, Kadowaki, Atsushi, Yaoita, Tsutomu, Sato, Naoki, Monma, Kimitsune, Kogure, Hiroaki, Tajima, Yoshio, Takanashi, Hideki, Tsuchiya, Yukihiro, Haniya, Kazuo, Ohto, Masao, Murata, Ikuo, Tanaka, Takashi, Sakabe, Takashi, Kato, Takashi, Koike, Tadashi, Watanabe, Tetsuya, Nakamura, Tetsuo, Kato, H., Ikai, I., Nishimura, N., Kobayashi, N., Ozawa, K., Ono, Katsuyuki, Sata, Michio, Abe, Hirohiko, Tanikawa, Kyuichi, Kadowaki, Ken, Ikoma, Jiro, Kojima, Yuji, Murata, Tetsuya, Kakehashi, Ryuichi, Ibe, Toshio, Kano, Uichiro, Ito, Tetsuo, Tanaka, Takeshi, Watanabe, Shozo, Suzuki, Shiro, Nakazawa, Osamu, Kohda, Kyuhei, Ohyama, Kohzo, Terada, Shoki, Sazaki, Katsuhiko, Kure, Teikichi, Morita, Koetsu, Shida, Osamu, Muramatsu, Hiroshi, Niitsu, Yoshiro, Tozuka, Shinichi, Sakai, Yoshinori, Ikeda, Takaaki, Koyama, Wataru, Sakamoto, Shigemi, Kanayama, Masaaki, Tanaka, Naohide, Arakawa, Yasuyuki, Matsuo, Yutaka, Takaguchi, Kouichi, Yamada, Gotaro, Matsuura, Kazuharu, Ikeda, Hirosi, Iwasaki, Yoshiaki, Nouso, Kazuhiro, Matsueda, Kazuhiro, Sawahara, Masahiko, Fujiki, Shigeatsu, Mizuno, Motowo, Yama, Shingo Kino, Tsuji, Takao, Nadano, Seijin, Horiike, Norio, Michitaka, Kojiro, Kumon, Izumi, Ogawa, Yasushi, Yamaguchi, Shuji, Onji, Morikazu, Ohta, Yasuyuki, Nishi, Masaaki, Matsuzaki, Yasushi, Tanaka, Naomi, Matsumoto, Hisashi, Chuganji, Yoshimichi, Osuga, Toshiaki, Shoji, S., Kurata, M., Wakashima, M., Itoh, Y., Hagiri, M., Kondou, T., Katayama, M., Nishizawa, K., Takikawa, H., Ohsawa, H., Miyake, M., Yamanaka, M., Ooka, Teruji, Akita, Masahiko, Kim, Hogen, Kato, Michio, Masuzawa, Manabu, Okuyama, Takumasa, Akiyama, Masahiko, Ishigami, Yoshitaka, Tamura, Kazuya, Fukui, Osamu, Abe, Hiroshi, Kamada, Takenobu, Arai, Ken, Shindo, Michiko, Okuno, Tadao, Matsumoto, Masayuki, Takeda, Makoto, Takino, Tatsuro, Sokawa, Yoshihiro, Omata, M., Yokosuka, O., Ito, Y., Hosoda, K., Ohto, M., Fuse, Yoshinobu, Kodama, Tadashi, Sugiyama, Kenji, Nakajo, Shinobu, Ajitsu, Shin, Takahashi, Tsuneo, Kuroe, K., Murata, Y., Ikeda, Hideo, and Tanikawa, Kyuichi
- Published
- 1990
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6. Serum total bile acid level as a sensitive indicator of hepatic histological improvement in chronic hepatitis C patients responding to interferon treatment
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SHIMA, TOSHIHIDE, TADA, HISASHI, MORIMOTO, MICHIO, NAKAGAWA, YOSHIHIRO, OBATA, HIROZUMI, SASAKI, TOSHIYUKI, PARK, HYOHUN, NAKAJO, SHINOBU, NAKASHIMA, TOSHIAKI, OKANOUE, TAKESHI, and KASHIMA, KEI
- Published
- 2000
7. Interleukin-28B polymorphisms are associated with an early viral response in patients receiving hepatitis C therapy
- Author
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OSAKI, RIE, primary, NISHIMURA, TAKASHI, additional, TAKEUCHI, TAKAYUKI, additional, IMAEDA, HIROTSUGU, additional, OKUMURA, YOSHIAKI, additional, SHIOYA, MAKOTO, additional, NAKAHARA, TAMIO, additional, BAMBA, SHIGEKI, additional, NAKAJO, SHINOBU, additional, FUJIYAMA, YOSHIHIDE, additional, and ANDOH, AKIRA, additional
- Published
- 2011
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8. Basic and Clinical Studies of Pazufloxacin on Infectious Enteritis Research Group of T-3761 on Infectious Enteritis (Manager; Shoichiro IRIMAJIRI)
- Author
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SAGARA, Hiroko, primary, YOSHIKAWA, Kouji, additional, TOMIZAWA, Isao, additional, TAKIZAWA, Yoshihiko, additional, NITTA, Yoshiro, additional, TSUNODA, Takafumi, additional, FUKUDA, Hiroyuki, additional, YAMAGUCHI, Tsuyoshi, additional, MASUDA, Gohta, additional, NEGISHI, Masayoshi, additional, AJISAWA, Atsushi, additional, MURATA, Misako, additional, OHNISHI, Kenji, additional, IRIMAJIRI, Shoichiro, additional, OBANA, Mitsuo, additional, MATSUMOTO, Fumio, additional, IMAI, Takero, additional, SAKURAI, Iwao, additional, TAKAHASHI, Takayuki, additional, MORI, Masamiki, additional, MIZUNO, Yoshiki, additional, KATOH, Kohji, additional, HOSODA, Shiro, additional, BAMBA, Tadao, additional, SASAKI, Masaya, additional, YOSHIKAWA, Kunio, additional, HIROTANI, Shuichi, additional, OGASAWARA, Takeshi, additional, SAKUMOTO, Hitoshi, additional, KOMAI, Yasunobu, additional, OOKUBO, Hideo, additional, KIM, Young Ki, additional, NAKAJO, Shinobu, additional, OBATA, Hirozumi, additional, SAKAUE, Yoshihiro, additional, YOSHIDA, Hideki, additional, GOTO, Tetsushi, additional, AISAKA, Tadakazu, additional, MIKAMI, Motoko, additional, KAGAWA, Kazunori, additional, IMAGAWA, Yatsuka, additional, FUKUYAMA, Masafumi, additional, MATSUBARA, Yoshio, additional, and SAITO, Makoto, additional
- Published
- 1996
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9. Basic and Clinical Studies of Fleroxacin on Infectious Enteritis
- Author
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SAGARA, Hiroko, primary, TOMIZAWA, Isao, additional, TAKIZAWA, Yoshihiko, additional, NITTA, Yoshiro, additional, TSUNODA, Takafumi, additional, YAMAGUCHI, Tsuyoshi, additional, MASUDA, Gohta, additional, NEGISHI, Masayoshi, additional, AJISAWA, Atsushi, additional, MURATA, Misako, additional, OHNISHI, Kenji, additional, IRIMAJIRI, Shoichiro, additional, MATSUOKA, Yasuo, additional, OBANA, Mitsuo, additional, MATSUMOTO, Fumio, additional, IMAI, Takeo, additional, AMANO, Fukiko, additional, NAKAMURA, Chie, additional, MURAMOTO, Akira, additional, KANOH, Hideyuki, additional, HOSODA, Shiro, additional, BABA, Tadao, additional, NAKAJO, Shinobu, additional, YOSHIKAWA, Kunio, additional, NAKAGAWA, Masao, additional, YASUDA, Norimasa, additional, KIM, Young-Ki, additional, AKAO, Mitsuru, additional, SAKAUE, Yoshihiro, additional, YAMADA, Junko, additional, YOSHIDA, Hideki, additional, KAWAGUCHI, Yoshio, additional, TAMURA, Kazuya, additional, MURAI, Masami, additional, AISAKA, Tadakazu, additional, TSUKIYAMA, Fumiaki, additional, MIKAMI, Motoko, additional, KURIMURA, Osamu, additional, TAMURA, Ritsu, additional, MIURA, Kousuke, additional, IMAGAWA, Yatsuka, additional, MATSUBARA, Yoshio, additional, SAITO, Makoto, additional, and NAKAYA, Rintaro, additional
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- 1994
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10. A Case of Turner's Syndrome with Crohn's Disease
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BAMBA, Tadao, primary, HASHIGUCHI, Masahiro, additional, DOI, Hisakazu, additional, SASAKI, Masaya, additional, KOYAMA, Shigeki, additional, FUJIYAMA, Yoshihide, additional, NAKAJO, Shinobu, additional, HOSODA, Shiro, additional, and CHIKAMOCHI, Nobuo, additional
- Published
- 1993
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11. The Clinical Usefulness of 13C-Triolein Breath Test for the Evaluation of Malabsorption Syndrome.
- Author
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BAMBA, Tadao, primary, CHIKAMOCHI, Nobuo, additional, FUSE, Kenji, additional, FUJIYAMA, Yoshihide, additional, NAKAJO, Shinobu, additional, HOSODA, Shiro, additional, WATANABE, Hiroyuki, additional, and MORIKAWA, Junji, additional
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- 1993
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12. Effect of Pectin on Formyl Methionyl-Leucyl-Phenylalanine(FMLP)-injured Intestinal Mucosa of Rat.
- Author
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BAMBA, Tadao, primary, CHUN, Woo, additional, NAKAJO, Shinobu, additional, and HOSODA, Shiro, additional
- Published
- 1992
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13. Interleukin-28B genotypes determine response to pegylated-interferon plus ribavirin therapy in patients with hepatitis C virus infection.
- Author
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Osaki R, Nishimura T, Shioya M, Takeuchi T, Okumura Y, Nakahara T, Bamba S, Nakajo S, Fujiyama Y, and Andoh A
- Subjects
- Adult, Aged, Alleles, Drug Therapy, Combination, Female, Genotype, Heterozygote, Humans, Interferon alpha-2, Interferons, Male, Middle Aged, Polymorphism, Single Nucleotide, Recombinant Proteins therapeutic use, Serotyping, Antiviral Agents therapeutic use, Hepatitis C drug therapy, Hepatitis C genetics, Interferon-alpha therapeutic use, Interleukins genetics, Polyethylene Glycols therapeutic use, Ribavirin therapeutic use
- Abstract
We recently reported that the interleukin (IL)-28B major genotype is a predictor of early suppression of the hepatitis C virus (HCV) at 12 weeks in response to pegylated interferon (PEG-IFN) plus ribavirin (RBV) therapy. The present study investigated the relationship between IL-28 genotypes and the virological response to PEG-IFN/RBV therapy at 24 and 48 weeks. Genotypes of the IL-28B rs8099917 T>G single nucleotide polymorphism were determined in 177 patients with HCV infection. Among them, 56 patients with HCV1 infection were treated with PEG-IFN/RBV. The frequency of the IL-28B major allele (TT) was 73.8% in patients with HCV serotype 1 and 86.3% in patients with HCV serotype 2. The rate of HCV-RNA positivity was significantly lower at 48 weeks in patients with the IL-28B major allele compared to patients with the IL-28B minor allele (TG or GG). The rate of HCV-RNA positivity at 24 weeks tended to be lower in patients with the IL-28B major allele, but there was no statistical significance (P=0.059). The sustained virological response (SVR) rate was 45.9% in patients with the IL-28B major allele, but 13.3% in patients with the IL-28B minor allele. The SVR correlated with the IL-28B major allele (OR=7.13, P=0.010), early virological response (OR=33.3, P=0.008), HCV-RNA ≤ 6.3 log IU/ml (OR=81.2, P=0.009) and γ-GTP ≤ 47 IU/l (OR=49.4, P=0.027). The IL-28B genotype is a significant pre-treatment predictor of the response to PEG-IFN/RBV therapy at 48 weeks in patients with HCV infection.
- Published
- 2012
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14. [A case of advanced gastric cancer attaining histological CR of paraaortic lymph node after TS-1/CDDP neoadjuvant chemotherapy].
- Author
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Koizumi Y, Hara A, Tomita M, Sakamoto K, Obata H, Shiomi T, Nakajo S, and Hashimoto K
- Subjects
- Aorta, Chemotherapy, Adjuvant, Cisplatin administration & dosage, Drug Administration Schedule, Drug Combinations, Gastrectomy, Gastric Mucosa pathology, Humans, Lymphatic Metastasis, Male, Middle Aged, Oxonic Acid administration & dosage, Pyridines administration & dosage, Remission Induction, Stomach Neoplasms pathology, Stomach Neoplasms surgery, Tegafur administration & dosage, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Lymph Nodes pathology, Stomach Neoplasms drug therapy
- Abstract
A 60-year-old male complaining of anemic symptoms went through examinations and was diagnosed with gastric cancer (cardia, type 3', cT2, cN3, cH0, cP0, cM0, cStage IV). Further inspection showed multiple lymph node metastases, including, No. 1, 3, 7, 11, and 16 (paraaortic LNs). Poor prognosis was predicted, yet we tried neoadjuvant chemotherapy (NAC) expecting down staging of the tumor. With the efficacy and safety previously proven, we chose TS-1 + CDDP as NAC regimen. TS-1 (tegafur gimestat otastat potassium, = 80 mg/m2) was administered orally for 21 days, followed by CDDP (cisplatin, = 60 mg/m2) i.v. on day 9. One course was completed without any significant adverse effects. The tumor itself showed PR-MR to the chemotherapy, but all the lymph nodes were expected to attain PR from CT findings. Total gastrectomy, lymph node dissection (D3) with Roux-en-Y reconstruction was performed, and histological re-evaluation was made. Macroscopically, the stomach seemed to be penetrated into serosa by the tumor, i.e., se invasion was suggested, yet histologically no cancerous cells were detected within mp and ss layer. Many of the lymph nodes were replaced with fibrosis, some with normal lymph node structure remained. Definitely no malignant cells were detected throughout all the lymph node specimens (Grade 3). Because pathological CR of paraaortic lymph nodes has never been reported previously, this case shows TS-1 + CDDP as a promising NAC regimen for advanced gastric cancer, in a sense that tumors once diagnosed as inoperable would still have the possibility of CR.
- Published
- 2003
15. [A case of stomach cancer in which TS-1 neoadjuvant therapy was effective against multiple hepatic metastasis, allowing a radical cure A surgery].
- Author
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Tanino M, Mizuno C, Shiomi T, Shima T, Nakajo S, Hara A, and Hashimoto K
- Subjects
- Adenocarcinoma, Scirrhous secondary, Drug Administration Schedule, Drug Combinations, Humans, Liver Neoplasms secondary, Male, Middle Aged, Neoadjuvant Therapy, Stomach Neoplasms pathology, Adenocarcinoma, Scirrhous drug therapy, Antimetabolites, Antineoplastic therapeutic use, Gastrectomy, Liver Neoplasms drug therapy, Oxonic Acid therapeutic use, Pyridines therapeutic use, Stomach Neoplasms drug therapy, Stomach Neoplasms surgery, Tegafur therapeutic use
- Abstract
It is believed that multiple hepatic metastases from stomach cancer are highly refractory, and resistant to clinical treatment. In the present study, TS-1 neoadjuvant therapy administered orally in a single course brought about CR in the hepatic metastatic foci and PR in the primary foci, thus enabling grade A radical extirpation in a case of advanced stomach cancer. The patient continued to be treated on an ambulatory basis. His peri- and post-operative courses were satisfactory and the treatment was completed without the development of adverse effects.
- Published
- 2002
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