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570 results on '"Nakao, Makoto"'

10. Sasa veitchii extract alleviates nonalcoholic steatohepatitis in methionine–choline deficient diet‐induced mice by regulating peroxisome proliferator‐activated receptor alpha

Author

Yoshioka, Hiroki, primary, Wu, Sixun, additional, Moriishi, Takeshi, additional, Tsukiboshi, Yosuke, additional, Yokota, Satoshi, additional, Miura, Nobuhiko, additional, Yoshikawa, Masae, additional, Inagaki, Naoki, additional, Matsushita, Yuki, additional, and Nakao, Makoto, additional

Published
2023
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13. 1K PUR Dispersion to 2K Waterbome Coatings: with Comparable Performance

Author

Nakao, Makoto

Subjects
Polyurethanes -- Properties -- Usage, Paints -- Properties -- Research, Polymer crosslinking -- Chemical properties, Business, Chemicals, plastics and rubber industries
Abstract

INTRODUCTION Two-component waterborne polyurethane (2KWB PU) coatings have been recognized as coatings with excellent performance properties, and they are used in a wide variety of applications. (1) However, they require [...]

Published
2019

16. Lung Cancer Complicated by Relapsing Polychondritis

Author

Arakawa, Sosuke, primary, Nakao, Makoto, additional, Sone, Kazuki, additional, Hayashi, Shuntaro, additional, Sugihara, Masahiro, additional, Hirata, Yuya, additional, Kuriyama, Mamiko, additional, Takeda, Norihisa, additional, Ohtakara, Kazuhiro, additional, Horikawa, Yoshimi, additional, and Muramatsu, Hideki, additional

Published
2023
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20. HIGH-PERFORMANCE Waterborne Wood Floor Coatings: An Easy-to-Apply, One-Component Formulation with the Physical Properties of o Two-Component Formulation

Author

Rosales, Eva Tejada, Sanchez, Berta Vega, Nakao, Makoto, Reinstadtler, Steven, and Miller, Adam

Subjects
Polyurethanes, Wood flooring, Business, Chemicals, plastics and rubber industries
Abstract

Site-applied polyurethane coatings for wood flooring are forecast to grow at a 5.5% CAGR rate for 2018-2023. This is more than double the estimated U.S. GDP rate during the same [...]

Published
2020

23. Treatment of Cryptococcus gattii Infection Using Voriconazole

Author

Nakao, Makoto, Fujita, Kohei, Arakawa, Sousuke, Hayashi, Shuntaro, Tomita, Saori, Sato, Hidefumi, and Muramatsu, Hideki

Subjects
Adult, Male, Antifungal Agents, fluconazole, voriconazole, Cryptococcus neoformans, Humans, Case Report, Cryptococcus gattii, Cryptococcosis, Microbial Sensitivity Tests
Abstract

We previously reported a 39-year-old man who presented with pulmonary and cerebral Cryptococcus gattii (genotype VGIIa) infection and was successfully treated with liposomal amphotericin B and flucytosine induction therapy. Following induction therapy, oral fluconazole treatment was initiated as consolidation therapy. However, the patient complained of progressively worsening headache, presenting an elevated cerebrospinal fluid (CSF) cell count. The minimum inhibitory concentrations of the CSF isolate were 8 and 0.12 μg/mL for fluconazole and voriconazole, respectively. The oral administration of voriconazole for more than 18 months alleviated his symptoms. Voriconazole might be useful for controlling refractory cases of C. gattii infection.

Published
2021

28. Sasa veitchii extract induces anticancer effects via inhibition of cyclin D1 expression in MCF-7 cells

Author

Ichimaru, Yoshimi, Kanaeda, Natsuki, Tominaga, Sarah, Suzui, Masumi, Maeda, Tohru, Fujii, Hirohisa, Nakao, Makoto, and Yoshioka, Hiroki

Subjects
breast cancer, sodium copper chlorophyllin, cyclin D1, Sasa veitchii
Abstract

Sasa veitchii and other Sasa species are traditional medicinal herbs belonging to a group of Japanese bamboos collectively called Kumazasa, and these species possess the potential for a wide variety of uses. The present study aimed to elucidate the anticancer mechanisms exerted by S. veitchii extract (SE) against a human breast cancer cell line, MCF-7 cells. Freeze-dried Sunchlon® was used as the SE, and cell proliferation activity was measured using the [3H]-thymidine incorporation assay. Induction of apoptosis was assessed via Annexin V and caspase-3 fluorescent staining, the induction of necrosis was measured via propidium iodide staining, and cell cycle-related protein expression was determined using western blot-ting. The IC50 value of the SE was 7.7 μg/mL in MCF-7 cells. Although the primary active ingredient in Sunchlon® is sodium copper chlorophyllin (0.25%), the present results indicated that ingredients other than SCC exert anti-cancer activities (the IC50 value of SCC was 715 μg/mL), and late apoptosis or necrosis was induced in an SE dose-dependent manner. The expression levels of cyclin D1 and Cdk6 were decreased after SE treatment, and there was no change in the Cdk1/2 expression levels. Additionally, the expression of the necrosis-related cell death indicators RIP1 and RIP3 was increased in response to high-dose SE treatments, and this was indicative of cells preparing for programmed cell death. SE induces cell death in MCF-7 cells via the inhibition of cyclin D1 expression at low concentrations, and this extract induces programmed necrosis (necroptosis) by potentiating RIP1/RIP3 expression.

Published
2020

29. Enhanced monopole and dipole transitions in nuclei induced by α cluster structures

Author

Ito Makoto, Nakao Makoto, Okuno Tomoyuki, and Ebata Syuuichiro

Subjects
Physics, QC1-999
Abstract

Enhancement of the monopole and dipole transitions in the low-lying state is discussed on the basis of the microscopic and macroscopic α cluster models. Theoretical calculation clearly demonstrates that the strength of the monopole and dipole transitions are strongly enhanced by the excitation in the relative motion of the α cluster and the residual nucleus. The transition strength induced by the α excitation appears as the discrete distribution, and its excitation energy is much lower than the excitation energy of the single nucleon excitation, which is expected from the naive mean field picture.

Published
2019
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31. A Case of Diffuse Large B-Cell Lymphoma Successfully Diagnosed Using Multiple Modalities to Evaluate Specimens From Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration

Author

KINOSHITA, Ryosuke, primary, NAKAO, Makoto, additional, TOMITA, Saori, additional, HAYASHI, Syuntaro, additional, SUGIHARA, Masahiro, additional, HIRATA, Yuya, additional, ARAKAWA, Sosuke, additional, KURIYAMA, Mamiko, additional, FUJITA, Kohei, additional, SONE, Kazuki, additional, ASAO, Yu, additional, and MURAMATSU, Hideki, additional

Published
2022
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36. Evidence of enhanced three α radius in α + 12C inelastic scattering

Author

Ito Makoto and Nakao Makoto

Subjects
Physics, QC1-999
Abstract

The microscopic coupled-channels calculations (MCC), which is based on precise internal wave functions and a realistic nucleon-nucleon interaction, is performed for the α + 12C inelastic scattering in the energy range of Eα = 80 to 400 MeV. The MCC calculations nicely reproduce the observed differential cross sections for the elastic and inelastic scattering, which goes to the 21+, 31−, 02+ states. The partial wave analysis for the differential cross sections has also performed. From the partial wave analysis, the nuclear radius of three α rotational state in 12C with a life time of 10-21 second, which has been expected to have much more extended radius than the ground 12C nucleus, is speculated. Present analysis predicts about 1.0 fm enhancement in the matter radius of the three α rotational state in comparison to the normal radius of the ground state, which is known to be proportional to the mass number to the one third. The spatial extension of the three α rotational state is comparable to the extended radius observed in the neutron halo phenomena. Constraint on the recent ab-initio calculation for the 3α states in 12C is also discussed.

Published
2017
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