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2. Dietary magnesium intake and risk of incident coronary heart disease in men: A prospective cohort study

Author

Tsugane, S., Sawada, N., Iwasaki, M., Sasazuki, S., Yamaji, T., Shimazu, T., Hanaoka, T., Ogata, J., Baba, S., Mannami, T., Okayama, A., Kokubo, Y., Miyakawa, K., Saito, F., Koizumi, A., Sano, Y., Hashimoto, I., Ikuta, T., Tanaba, Y., Sato, H., Roppongi, Y., Takashima, T., Suzuki, H., Miyajima, Y., Suzuki, N., Nagasawa, S., Furusugi, Y., Nagai, N., Ito, Y., Komatsu, S., Minamizono, T., Sanada, H., Hatayama, Y., Kobayashi, F., Uchino, H., Shirai, Y., Kondo, T., Sasaki, R., Watanabe, Y., Miyagawa, Y., Kobayashi, Y., Machida, M., Kobayashi, K., Tsukada, M., Kishimoto, Y., Takara, E., Fukuyama, T., Kinjo, M., Irei, M., Sakiyama, H., Imoto, K., Yazawa, H., Seo, T., Seiko, A., Ito, F., Shoji, F., Saito, R., Murata, A., Minato, K., Motegi, K., Fujieda, T., Yamato, S., Matsui, K., Abe, T., Katagiri, M., Suzuki, M., Doi, M., Terao, A., Ishikawa, Y., Tagami, T., Sueta, H., Doi, H., Urata, M., Okamoto, N., Ide, F., Goto, H., Fujita, R., Onga, N., Takaesu, H., Uehara, M., Nakasone, T., Yamakawa, M., Horii, F., Asano, I., Yamaguchi, H., Aoki, K., Maruyama, S., Ichii, M., Takano, M., Tsubono, Y., Suzuki, K., Honda, Y., Yamagishi, K., Sakurai, S., Tsuchiya, N., Kabuto, M., Yamaguchi, M., Matsumura, Y., Sasaki, S., Watanabe, S., Akabane, M., Kadowaki, T., Inoue, M., Noda, M., Mizoue, T., Kawaguchi, Y., Takashima, Y., Yoshida, Y., Nakamura, K., Takachi, R., Ishihara, J., Matsushima, S., Natsukawa, S., Shimizu, H., Sugimura, H., Tominaga, S., Hamajima, N., Iso, H., Sobue, T., Iida, M., Ajiki, W., Ioka, A., Sato, S., Maruyama, E., Konishi, M., Okada, K., Saito, I., Yasuda, N., Kono, S., Akiba, S., Isobe, T., Kokubo, Yoshihiro, Saito, Isao, Iso, Hiroyasu, Yamagishi, Kazumasa, Yatsuya, Hiroshi, Ishihara, Junko, Maruyama, Koutatsu, Inoue, Manami, Sawada, Norie, and Tsugane, Shoichiro

Published
2018
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3. Dietary patterns and colorectal cancer risk in middle-aged adults: A large population-based prospective cohort study

Author

Tsugane, S., Sawada, N., Iwasaki, M., Sasazuki, S., Yamaji, T., Shimazu, T., Hanaoka, T., Ogata, J., Baba, S., Mannami, T., Okayama, A., Kokubo, Y., Miyakawa, K., Saito, F., Koizumi, A., Sano, Y., Hashimoto, I., Ikuta, T., Tanaba, Y., Sato, H., Roppongi, Y., Takashima, T., Suzuki, H., Miyajima, Y., Suzuki, N., Nagasawa, S., Furusugi, Y., Nagai, N., Ito, Y., Komatsu, S., Minamizono, T., Sanada, H., Hatayama, Y., Kobayashi, F., Uchino, H., Shirai, Y., Kondo, T., Sasaki, R., Watanabe, Y., Miyagawa, Y., Kobayashi, Y., Machida, M., Kobayashi, K., Tsukada, M., Kishimoto, Y., Takara, E., Fukuyama, T., Kinjo, M., Irei, M., Sakiyama, H., Imoto, K., Yazawa, H., Seo, T., Seiko, A., Ito, F., Shoji, F., Saito, R., Murata, A., Minato, K., Motegi, K., Fujieda, T., Yamato, S., Matsui, K., Abe, T., Katagiri, M., Suzuki, M., Doi, M., Terao, A., Ishikawa, Y., Tagami, T., Sueta, H., Doi, H., Urata, M., Okamoto, N., Ide, F., Goto, H., Fujita, R., Onga, N., Takaesu, H., Uehara, M., Nakasone, T., Yamakawa, M., Horii, F., Asano, I., Yamaguchi, H., Aoki, K., Maruyama, S., Ichii, M., Takano, M., Tsubono, Y., Suzuki, K., Honda, Y., Yamagishi, K., Sakurai, S., Tsuchiya, N., Kabuto, M., Yamaguchi, M., Matsumura, Y., Sasaki, S., Watanabe, S., Akabane, M., Kadowaki, T., Inoue, M., Noda, M., Mizoue, T., Kawaguchi, Y., Takashima, Y., Yoshida, Y., Nakamura, K., Takachi, R., Ishihara, J., Matsushima, S., Natsukawa, S., Shimizu, H., Sugimura, H., Tominaga, S., Hamajima, N., Iso, H., Sobue, T., Iida, M., Ajiki, W., Ioka, A., Sato, S., Maruyama, E., Konishi, M., Okada, K., Saito, I., Yasuda, N., Kono, S., Akiba, S., Isobe, T., Sato, Y., Shin, Sangah, Saito, Eiko, Sawada, Norie, Ishihara, Junko, Takachi, Ribeka, Nanri, Akiko, Shimazu, Taichi, Yamaji, Taiki, Iwasaki, Motoki, Sasazuki, Shizuka, Inoue, Manami, and Tsugane, Shoichiro

Published
2018
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4. Plasma levels of n-3 fatty acids and risk of coronary heart disease among Japanese: The Japan Public Health Center-based (JPHC) study

Author

Tsugane, S., Sawada, N., Iwasaki, M., Sasazuki, S., Yamaji, T., Shimazu, T., Goto, A., Hidaka, A., Hanaoka, T., Ogata, J., Baba, S., Mannami, T., Okayama, A., Kokubo, Y., Miyakawa, K., Saito, F., Koizumi, A., Sano, Y., Hashimoto, I., Ikuta, T., Tanaba, Y., Sato, H., Roppongi, Y., Takashima, T., Suzuki, H., Miyajima, Y., Suzuki, N., Nagasawa, S., Furusugi, Y., Nagai, N., Ito, Y., Komatsu, S., Minamizono, T., Sanada, H., Hatayama, Y., Kobayashi, F., Uchino, H., Shirai, Y., Kondo, T., Sasaki, R., Watanabe, Y., Miyagawa, Y., Kobayashi, Y., Machida, M., Kobayashi, K., Tsukada, M., Kishimoto, Y., Takara, E., Fukuyama, T., Kinjo, M., Irei, M., Sakiyama, H., Imoto, K., Yazawa, H., Seo, T., Seiko, A., Ito, F., Shoji, F., Saito, R., Murata, A., Minato, K., Motegi, K., Fujieda, T., Yamato, S., Doi, M., Matsui, K., Abe, T., Katagiri, M., Suzuki, M., Terao, A., Ishikawa, Y., Tagami, T., Sueta, H., Doi, H., Urata, M., Okamoto, N., Ide, F., Goto, H., Fujita, R., Sou, Y., Onga, N., Takaesu, H., Uehara, M., Nakasone, T., Yamakawa, M., Horii, F., Asano, I., Yamaguchi, H., Aoki, K., Maruyama, S., Ichii, M., Takano, M., Tsubono, Y., Suzuki, K., Honda, Y., Yamagishi, K., Sakurai, S., Tsuchiya, N., Kabuto, M., Yamaguchi, M., Matsumura, Y., Sasaki, S., Watanabe, S., Akabane, M., Kadowaki, T., Inoue, M., Noda, M., Mizoue, T., Kawaguchi, Y., Takashima, Y., Yoshida, Y., Nakamura, K., Takachi, R., Ishihara, J., Matsushima, S., Natsukawa, S., Shimizu, H., Sugimura, H., Tominaga, S., Hamajima, N., Iso, H., Sobue, T., Iida, M., Ajiki, W., Ioka, A., Sato, S., Maruyama, E., Konishi, M., Okada, K., Saito, I., Yasuda, N., Kono, S., Akiba, S., Isobe, T., Sato, Y., Hamazaki, Kei, Iso, Hiroyasu, Eshak, Ehab S., Ikehara, Satoyo, Ikeda, Ai, Iwasaki, Motoki, Hamazaki, Tomohito, and Tsugane, Shoichiro

Published
2018
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9. Association of green tea consumption with mortality due to all causes and major causes of death in a Japanese population: the Japan Public Health Center-based Prospective Study (JPHC Study)

Author

Tsugane, S., Sawada, N., Iwasaki, M., Sasazuki, S., Yamaji, T., Shimazu, T., Hanaoka, T., Ogata, J., Baba, S., Mannami, T., Okayama, A., Kokubo, Y., Miyakawa, K., Saito, F., Koizumi, A., Sano, Y., Hashimoto, I., Ikuta, T., Tanaba, Y., Sato, H., Roppongi, Y., Takashima, T., Miyajima, Y., Suzuki, N., Nagasawa, S., Furusugi, Y., Nagai, N., Ito, Y., Komatsu, S., Minamizono, T., Sanada, H., Hatayama, Y., Kobayashi, F., Uchino, H., Shirai, Y., Kondo, T., Sasaki, R., Watanabe, Y., Miyagawa, Y., Kobayashi, Y., Machida, M., Kobayashi, K., Tsukada, M., Kishimoto, Y., Takara, E., Fukuyama, T., Kinjo, M., Irei, M., Sakiyama, H., Imoto, K., Yazawa, H., Seo, T., Seiko, A., Ito, F., Shoji, F., Saito, R., Murata, A., Minato, K., Motegi, K., Fujieda, T., Yamato, S., Matsui, K., Abe, T., Katagiri, M., Suzuki, M., Doi, M., Terao, A., Ishikawa, Y., Tagami, T., Sueta, H., Doi, H., Urata, M., Okamoto, N., Ide, F., Goto, H., Onga, N., Takaesu, H., Uehara, M., Nakasone, T., Yamakawa, M., Horii, F., Asano, I., Yamaguchi, H., Aoki, K., Maruyama, S., Ichii, M., Takano, M., Tsubono, Y., Suzuki, K., Honda, Y., Yamagishi, K., Sakurai, S., Tsuchiya, N., Kabuto, M., Yamaguchi, M., Matsumura, Y., Sasaki, S., Watanabe, S., Akabane, M., Kadowaki, T., Inoue, M., Noda, M., Mizoue, T., Kawaguchi, Y., Takashima, Y., Yoshida, Y., Nakamura, K., Takachi, R., Ishihara, J., Matsushima, S., Natsukawa, S., Shimizu, H., Sugimura, H., Tominaga, S., Hamajima, N., Iso, H., Sobue, T., Iida, M., Ajiki, W., Ioka, A., Sato, S., Maruyama, E., Konishi, M., Okada, K., Saito, I., Yasuda, N., Kono, S., Akiba, S., Saito, Eiko, Inoue, Manami, Sawada, Norie, Shimazu, Taichi, Yamaji, Taiki, Iwasaki, Motoki, Sasazuki, Shizuka, Noda, Mitsuhiko, Iso, Hiroyasu, and Tsugane, Shoichiro

Published
2015
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10. Alcohol consumption and bladder cancer risk with or without the flushing response: The Japan Public Health Center‐based Prospective Study

Author

Masaoka, Hiroyuki, Matsuo, Keitaro, Sawada, Norie, Yamaji, Taiki, Goto, Atsushi, Shimazu, Taichi, Iwasaki, Motoki, Inoue, Manami, Eto, Masatoshi, Tsugane, Shoichiro, Tsugane, S., Sawada, N., Iwasaki, M., Sasazuki, S., Yamaji, T., Shimazu, T., Hanaoka, T., Ogata, J., Baba, S., Mannami, T., Okayama, A., Kokubo, Y., Miyakawa, K., Saito, F., Koizumi, A., Sano, Y., Hashimoto, I., Ikuta, T., Tanaba, Y., Sato, H., Roppongi, Y., Takashima, T., Suzuki, H., Miyajima, Y., Suzuki, N., Nagasawa, S., Furusugi, Y., Nagai, N., Ito, Y., Komatsu, S., Minamizono, T., Sanada, H., Hatayama, Y., Kobayashi, F., Uchino, H., Shirai, Y., Kondo, T., Sasaki, R., Watanabe, Y., Miyagawa, Y., Kobayashi, Y., Machida, M., Kobayashi, K., Tsukada, M., Kishimoto, Y., Takara, E., Fukuyama, T., Kinjo, M., Irei, M., Sakiyama, H., Imoto, K., Yazawa, H., Seo, T., Seiko, A., Ito, F., Shoji, F., Saito, R., Murata, A., Minato, K., Motegi, K., Fujieda, T., Yamato, S., Matsui, K., Abe, T., Katagiri, M., Suzuki, M., Matsui, K., Doi, M., Terao, A., Ishikawa, Y., Tagami, T., Sueta, H., Doi, H., Urata, M., Okamoto, N., Ide, F., Goto, H., Fujita, R, Sakiyama, H., Onga, N., Takaesu, H., Uehara, M., Nakasone, T., Yamakawa, M., Horii, F., Asano, I., Yamaguchi, H., Aoki, K., Maruyama, S., Ichii, M., Takano, M., Tsubono, Y., Suzuki, K., Honda, Y., Yamagishi, K., Sakurai, S., Tsuchiya, N., Kabuto, M., Yamaguchi, M., Matsumura, Y., Sasaki, S., Watanabe, S., Akabane, M., Kadowaki, T., Inoue, M., Noda, M., Mizoue, T., Kawaguchi, Y., Takashima, Y., Yoshida, Y., Nakamura, K., Takachi, R., Ishihara, J., Matsushima, S., Natsukawa, S., Shimizu, H., Sugimura, H., Tominaga, S., Hamajima, N., Iso, H., Sobue, T., Iida, M., Ajiki, W., Ioka, A., Sato, S., Maruyama, E., Konishi, M., Okada, K., Saito, I., Yasuda, N., Kono, S., Akiba, S., Isobe, T., and Sato, Y.

Published
2017
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11. Smoking and alcohol and subsequent risk of myelodysplastic syndromes in Japan: the Japan Public Health Centre‐based Prospective Study

Author

Ugai, Tomotaka, Matsuo, Keitaro, Sawada, Norie, Iwasaki, Motoki, Yamaji, Taiki, Shimazu, Taichi, Sasazuki, Shizuka, Inoue, Manami, Kanda, Yoshinobu, Tsugane, Shoichiro, Hanaoka, T., Ogata, J., Baba, S., Mannami, T., Okayama, A., Kokubo, Y., Miyakawa, K., Saito, F., Koizumi, A., Sano, Y., Hashimoto, I., Ikuta, T., Tanaba, Y., Sato, H., Roppongi, Y., Takashima, T., Suzuki, H., Miyajima, Y., Suzuki, N, Nagasawa, S., Furusugi, Y., Nagai, N., Ito, Y., Komatsu, S., Minamizono, T., Sanada, H., Hatayama, Y., Kobayashi, F., Uchino, H., Shirai, Y., Kondo, T., Sasaki, R., Watanabe, Y., Miyagawa, Y., Kobayashi, Y., Machida, M., Kobayashi, K., Tsukada, M., Kishimoto, Y., Takara, E., Fukuyama, T., Kinjo, M., Irei, M., Sakiyama, H., Imoto, K., Yazawa, H., Seo, T., Seiko, A., Ito, F., Shoji, F., Saito, R., Murata, A., Minato, K., Motegi, K., Fujieda, T., Yamato, S., Matsui, K., Abe, T., Katagiri, M., Suzuki, M., Matsui, K., Doi, M., Terao, A., Ishikawa, Y., Tagami, T., Sueta, H., Doi, H., Urata, M., Okamoto, N., Ide, F., Goto, H., Fujita, R., Sakiyama, H., Onga, N., Takaesu, H., Uehara, M., Nakasone, T., Yamakawa, M., Horii, F., Asano, I., Yamaguchi, H., Aoki, K., Maruyama, S., Ichii, M., Takano, M., Tsubono, Y., Suzuki, K., Honda, Y., Yamagishi, K., Sakurai, S., Tsuchiya, N., Kabuto, M., Yamaguchi, M., Matsumura, Y., Sasaki, S., Watanabe, S., Akabane, M., Kadowaki, T., Noda, M., Mizoue, T., Kawaguchi, Y., Takashima, Y., Yoshida, Y., Nakamura, K., Takachi, R., Ishihara, J., Matsushima, S., Natsukawa, S., Shimizu, H., Sugimura, H., Tominaga, S., Hamajima, N., Iso, H., Sobue, T., Iida, M., Ajiki, W., Ioka, A., Sato, S., Maruyama, E., Konishi, M., Okada, K., Saito, I., Yasuda, N., Kono, S., Akiba, S., Isobe, T., and Sato, Y.

Published
2017
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12. High serum total cholesterol is associated with suicide mortality in Japanese women

Author

Svensson, T., Inoue, M., Sawada, N., Charvat, H., Mimura, M., Tsugane, S., Iwasaki, M., Sasazuki, S., Yamaji, T., Shimazu, T., Hanaoka, T., Ogata, J., Baba, S., Mannami, T., Okayama, A., Kokubo, Y., Miyakawa, K., Saito, F., Koizumi, A., Sano, Y., Hashimoto, I., Ikuta, T., Tanaba, Y., Sato, H., Roppongi, Y., Takashima, T., Suzuki, H., Miyajima, Y., Suzuki, N., Nagasawa, S., Furusugi, Y., Nagai, N., Ito, Y., Komatsu, S., Minamizono, T., Sanada, H., Hatayama, Y., Kobayashi, F., Uchino, H., Shirai, Y., Kondo, T., Sasaki, R., Watanabe, Y., Miyagawa, Y., Kobayashi, Y., Machida, M., Kobayashi, K., Tsukada, M., Kishimoto, Y., Takara, E., Fukuyama, T., Kinjo, M., Irei, M., Sakiyama, H., Imoto, K., Yazawa, H., Seo, T., Seiko, A., Ito, F., Shoji, F., Saito, R., Murata, A., Minato, K., Motegi, K., Fujieda, T., Yamato, S., Matsui, K., Abe, T., Katagiri, M., Suzuki, M., Matsui, K., Doi, M., Terao, A., Ishikawa, Y., Tagami, T., Sueta, H., Doi, H., Urata, M., Okamoto, N., Ide, F., Goto, H., Fujita, R, Sakiyama, H., Onga, N., Takaesu, H., Uehara, M., Nakasone, T., Yamakawa, M., Horii, F, Asano, I., Yamaguchi, H., Aoki, K., Maruyama, S., Ichii, M, Ichii, M, Takano, M., Tsubono, Y., Honda, Y., Yamagishi, K., Sakurai, S., Tsuchiya, N., Kabuto, M., Yamaguchi, M., Matsumura, Y., Sasaki, S., Watanabe, S., Akabane, M., Kadowaki, T., Noda, M., Mizoue, T., Kawaguchi, Y., Takashima, Y., Yoshida, Y., Nakamura, K., Takachi, R., Ishihara, J., Matsushima, S., Natsukawa, S., Shimizu, H., Sugimura, H., Tominaga, S., Hamajima, N., Iso, H., Sobue, T., Iida, M., Ajiki, W., Ioka, A., Sato, S., Maruyama, E., Konishi, M., Okada, K., Saito, I., Yasuda, N., Kono, S., Akiba, S., Isobe, T., and Sato, Y.

Published
2017
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13. Coping strategies and risk of cardiovascular disease incidence and mortality: the Japan Public Health Center-based prospective Study

Author

Svensson, Thomas, Inoue, Manami, Sawada, Norie, Yamagishi, Kazumasa, Charvat, Hadrien, Saito, Isao, Kokubo, Yoshihiro, Iso, Hiroyasu, Kawamura, Noriyuki, Shibuya, Kenji, Mimura, Masaru, Tsugane, Shoichiro, Tsugane, S., Tsugane, S., Sawada, N., Iwasaki, M., Sasazuki, S., Shimazu, T., Yamaji, T., Hanaoka, T., Ogata, J., Baba, S., Mannami, T., Okayama, A., Kokubo, Y., Miyakawa, K., Saito, F., Koizumi, A., Sano, Y., Hashimoto, I., Ikuta, T., Tanaba, Y., Sato, H., Roppongi, Y., Takashima, T., Miyajima, Y., Suzuki, N., Nagasawa, S., Furusugi, Y., Nagai, N., Ito, Y., Komatsu, S., Minamizono, T., Sanada, H., Hatayama, Y., Kobayashi, F., Uchino, H., Shirai, Y., Kondo, T., Sasaki, R., Watanabe, Y., Miyagawa, Y., Kobayashi, Y., Machida, M., Kobayashi, K., Tsukada, M., Kishimoto, Y., Takara, E., Fukuyama, T., Kinjo, M., Irei, M., Sakiyama, H., Imoto, K., Yazawa, H., Seo, T., Seiko, A., Ito, F., Shoji, F., Saito, R., Murata, A., Minato, K., Motegi, K., Fujieda, T., Yamato, S., Matsui, K., Abe, T., Katagiri, M., Suzuki, M., Matsui, K., Doi, M., Terao, A., Ishikawa, Y., Tagami, T., Sueta, H., Doi, H., Urata, M., Okamoto, N., Ide, F., Goto, H., Sakiyama, H., Onga, N., Takaesu, H., Uehara, M., Nakasone, T., Yamakawa, M., Horii, F., Asano, I., Yamaguchi, H., Aoki, K., Maruyama, S., Ichii, M., Takano, M., Tsubono, Y., Suzuki, K., Honda, Y., Yamagishi, K., Sakurai, S., Tsuchiya, N., Kabuto, M., Yamaguchi, M., Matsumura, Y., Sasaki, S., Watanabe, S., Akabane, M., Kadowaki, T., Inoue, M., Noda, M., Mizoue, T., Kawaguchi, Y., Takashima, Y., Yoshida, Y., Nakamura, K., Takachi, R., Ishihara, J., Matsushima, S., Natsukawa, S., Shimizu, H., Sugimura, H., Tominaga, S., Hamajima, N., Iso, H., Sobue, T., Iida, M., Ajiki, W., Ioka, A., Sato, S., Maruyama, E., Konishi, M., Okada, K., Saito, I., Yasuda, N., Kono, S., and Akiba, S.

Published
2016
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19. Benign epithelial inclusion consisting of squamous metaplasia and small glandular elements in regional lymph node of a patient with tongue cancer : a case report and literature review

Author

Maruyama, T., Nakasone, T., Saio, M., Nishihara, K., Akira Matayoshi, Goto, T., Yoshimi, N., and Arasaki, A.

Subjects
Tongue cancer, cytokeratin 13, benign inclusions, metastasis, lymph node, cytokeratin 17
Abstract

There are occasional reports of unexpected pathological findings during neck dissection, including benign inclusions (BIs) in cervical lymph nodes, comprising squamous epithelial, glandular, thyroid, neval and mesothelial cells. BIs can mimic regional lymph node metastases, therefore, pathological diagnosis is important. However, criteria for immunohistochemical diagnosis of BIs are not established. We report a 73-year-old woman with tongue cancer with squamous metaplasia and a glandular BI in a regional lymph node. Clinical and radiographic assessment of the lesion led to diagnosis of tongue squamous cell carcinoma (T3N2bM0, Stage IVa). The patient underwent right-side total neck dissection with wide local excision of the tongue tumor. All the lymph nodes in the dissection specimen were pathologically negative. In contrast, one BI in a level III lymph node was found incidentally. We could not diagnose this lesion clearly by routine pathological examination because of the lack of criteria for immunohistochemical diagnosis of BIs. To the best of our knowledge, BIs comprising squamous metaplasia and small glandular elements in the regional lymph nodes of patients with head and neck cancer have not been reported. We histologically predicted the lesion as BI, which was confirmed by additional immunohistochemical staining for cytokeratin 13 and 17. Clinicians should avoid misdiagnosis of metastases, which could lead to incorrect tumor staging and inadequate adjuvant therapy for patients with lymph node BIs. To distinguish BIs from metastases clearly, we recommend additional immunohistochemical staining for cytokeratin 13 and 17 in routinely stained sections of regional lymph nodes in patients with squamous cell carcinoma., 論文

Published
2016

21. Dietary magnesium intake and risk of incident coronary heart disease in men: A prospective cohort study

Author

Kokubo, Yoshihiro, primary, Saito, Isao, additional, Iso, Hiroyasu, additional, Yamagishi, Kazumasa, additional, Yatsuya, Hiroshi, additional, Ishihara, Junko, additional, Maruyama, Koutatsu, additional, Inoue, Manami, additional, Sawada, Norie, additional, Tsugane, Shoichiro, additional, Tsugane, S., additional, Sawada, N., additional, Iwasaki, M., additional, Sasazuki, S., additional, Yamaji, T., additional, Shimazu, T., additional, Hanaoka, T., additional, Ogata, J., additional, Baba, S., additional, Mannami, T., additional, Okayama, A., additional, Kokubo, Y., additional, Miyakawa, K., additional, Saito, F., additional, Koizumi, A., additional, Sano, Y., additional, Hashimoto, I., additional, Ikuta, T., additional, Tanaba, Y., additional, Sato, H., additional, Roppongi, Y., additional, Takashima, T., additional, Suzuki, H., additional, Miyajima, Y., additional, Suzuki, N., additional, Nagasawa, S., additional, Furusugi, Y., additional, Nagai, N., additional, Ito, Y., additional, Komatsu, S., additional, Minamizono, T., additional, Sanada, H., additional, Hatayama, Y., additional, Kobayashi, F., additional, Uchino, H., additional, Shirai, Y., additional, Kondo, T., additional, Sasaki, R., additional, Watanabe, Y., additional, Miyagawa, Y., additional, Kobayashi, Y., additional, Machida, M., additional, Kobayashi, K., additional, Tsukada, M., additional, Kishimoto, Y., additional, Takara, E., additional, Fukuyama, T., additional, Kinjo, M., additional, Irei, M., additional, Sakiyama, H., additional, Imoto, K., additional, Yazawa, H., additional, Seo, T., additional, Seiko, A., additional, Ito, F., additional, Shoji, F., additional, Saito, R., additional, Murata, A., additional, Minato, K., additional, Motegi, K., additional, Fujieda, T., additional, Yamato, S., additional, Matsui, K., additional, Abe, T., additional, Katagiri, M., additional, Suzuki, M., additional, Doi, M., additional, Terao, A., additional, Ishikawa, Y., additional, Tagami, T., additional, Sueta, H., additional, Doi, H., additional, Urata, M., additional, Okamoto, N., additional, Ide, F., additional, Goto, H., additional, Fujita, R., additional, Onga, N., additional, Takaesu, H., additional, Uehara, M., additional, Nakasone, T., additional, Yamakawa, M., additional, Horii, F., additional, Asano, I., additional, Yamaguchi, H., additional, Aoki, K., additional, Maruyama, S., additional, Ichii, M., additional, Takano, M., additional, Tsubono, Y., additional, Suzuki, K., additional, Honda, Y., additional, Yamagishi, K., additional, Sakurai, S., additional, Tsuchiya, N., additional, Kabuto, M., additional, Yamaguchi, M., additional, Matsumura, Y., additional, Sasaki, S., additional, Watanabe, S., additional, Akabane, M., additional, Kadowaki, T., additional, Inoue, M., additional, Noda, M., additional, Mizoue, T., additional, Kawaguchi, Y., additional, Takashima, Y., additional, Yoshida, Y., additional, Nakamura, K., additional, Takachi, R., additional, Ishihara, J., additional, Matsushima, S., additional, Natsukawa, S., additional, Shimizu, H., additional, Sugimura, H., additional, Tominaga, S., additional, Hamajima, N., additional, Iso, H., additional, Sobue, T., additional, Iida, M., additional, Ajiki, W., additional, Ioka, A., additional, Sato, S., additional, Maruyama, E., additional, Konishi, M., additional, Okada, K., additional, Saito, I., additional, Yasuda, N., additional, Kono, S., additional, Akiba, S., additional, and Isobe, T., additional

Published
2018
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22. Dietary patterns and colorectal cancer risk in middle-aged adults: A large population-based prospective cohort study

Author

Shin, Sangah, primary, Saito, Eiko, additional, Sawada, Norie, additional, Ishihara, Junko, additional, Takachi, Ribeka, additional, Nanri, Akiko, additional, Shimazu, Taichi, additional, Yamaji, Taiki, additional, Iwasaki, Motoki, additional, Sasazuki, Shizuka, additional, Inoue, Manami, additional, Tsugane, Shoichiro, additional, Tsugane, S., additional, Sawada, N., additional, Iwasaki, M., additional, Sasazuki, S., additional, Yamaji, T., additional, Shimazu, T., additional, Hanaoka, T., additional, Ogata, J., additional, Baba, S., additional, Mannami, T., additional, Okayama, A., additional, Kokubo, Y., additional, Miyakawa, K., additional, Saito, F., additional, Koizumi, A., additional, Sano, Y., additional, Hashimoto, I., additional, Ikuta, T., additional, Tanaba, Y., additional, Sato, H., additional, Roppongi, Y., additional, Takashima, T., additional, Suzuki, H., additional, Miyajima, Y., additional, Suzuki, N., additional, Nagasawa, S., additional, Furusugi, Y., additional, Nagai, N., additional, Ito, Y., additional, Komatsu, S., additional, Minamizono, T., additional, Sanada, H., additional, Hatayama, Y., additional, Kobayashi, F., additional, Uchino, H., additional, Shirai, Y., additional, Kondo, T., additional, Sasaki, R., additional, Watanabe, Y., additional, Miyagawa, Y., additional, Kobayashi, Y., additional, Machida, M., additional, Kobayashi, K., additional, Tsukada, M., additional, Kishimoto, Y., additional, Takara, E., additional, Fukuyama, T., additional, Kinjo, M., additional, Irei, M., additional, Sakiyama, H., additional, Imoto, K., additional, Yazawa, H., additional, Seo, T., additional, Seiko, A., additional, Ito, F., additional, Shoji, F., additional, Saito, R., additional, Murata, A., additional, Minato, K., additional, Motegi, K., additional, Fujieda, T., additional, Yamato, S., additional, Matsui, K., additional, Abe, T., additional, Katagiri, M., additional, Suzuki, M., additional, Doi, M., additional, Terao, A., additional, Ishikawa, Y., additional, Tagami, T., additional, Sueta, H., additional, Doi, H., additional, Urata, M., additional, Okamoto, N., additional, Ide, F., additional, Goto, H., additional, Fujita, R., additional, Onga, N., additional, Takaesu, H., additional, Uehara, M., additional, Nakasone, T., additional, Yamakawa, M., additional, Horii, F., additional, Asano, I., additional, Yamaguchi, H., additional, Aoki, K., additional, Maruyama, S., additional, Ichii, M., additional, Takano, M., additional, Tsubono, Y., additional, Suzuki, K., additional, Honda, Y., additional, Yamagishi, K., additional, Sakurai, S., additional, Tsuchiya, N., additional, Kabuto, M., additional, Yamaguchi, M., additional, Matsumura, Y., additional, Sasaki, S., additional, Watanabe, S., additional, Akabane, M., additional, Kadowaki, T., additional, Inoue, M., additional, Noda, M., additional, Mizoue, T., additional, Kawaguchi, Y., additional, Takashima, Y., additional, Yoshida, Y., additional, Nakamura, K., additional, Takachi, R., additional, Ishihara, J., additional, Matsushima, S., additional, Natsukawa, S., additional, Shimizu, H., additional, Sugimura, H., additional, Tominaga, S., additional, Hamajima, N., additional, Iso, H., additional, Sobue, T., additional, Iida, M., additional, Ajiki, W., additional, Ioka, A., additional, Sato, S., additional, Maruyama, E., additional, Konishi, M., additional, Okada, K., additional, Saito, I., additional, Yasuda, N., additional, Kono, S., additional, Akiba, S., additional, Isobe, T., additional, and Sato, Y., additional

Published
2018
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23. Plasma levels of n-3 fatty acids and risk of coronary heart disease among Japanese: The Japan Public Health Center-based (JPHC) study

Author

Hamazaki, Kei, primary, Iso, Hiroyasu, additional, Eshak, Ehab S., additional, Ikehara, Satoyo, additional, Ikeda, Ai, additional, Iwasaki, Motoki, additional, Hamazaki, Tomohito, additional, Tsugane, Shoichiro, additional, Tsugane, S., additional, Sawada, N., additional, Iwasaki, M., additional, Sasazuki, S., additional, Yamaji, T., additional, Shimazu, T., additional, Goto, A., additional, Hidaka, A., additional, Hanaoka, T., additional, Ogata, J., additional, Baba, S., additional, Mannami, T., additional, Okayama, A., additional, Kokubo, Y., additional, Miyakawa, K., additional, Saito, F., additional, Koizumi, A., additional, Sano, Y., additional, Hashimoto, I., additional, Ikuta, T., additional, Tanaba, Y., additional, Sato, H., additional, Roppongi, Y., additional, Takashima, T., additional, Suzuki, H., additional, Miyajima, Y., additional, Suzuki, N., additional, Nagasawa, S., additional, Furusugi, Y., additional, Nagai, N., additional, Ito, Y., additional, Komatsu, S., additional, Minamizono, T., additional, Sanada, H., additional, Hatayama, Y., additional, Kobayashi, F., additional, Uchino, H., additional, Shirai, Y., additional, Kondo, T., additional, Sasaki, R., additional, Watanabe, Y., additional, Miyagawa, Y., additional, Kobayashi, Y., additional, Machida, M., additional, Kobayashi, K., additional, Tsukada, M., additional, Kishimoto, Y., additional, Takara, E., additional, Fukuyama, T., additional, Kinjo, M., additional, Irei, M., additional, Sakiyama, H., additional, Imoto, K., additional, Yazawa, H., additional, Seo, T., additional, Seiko, A., additional, Ito, F., additional, Shoji, F., additional, Saito, R., additional, Murata, A., additional, Minato, K., additional, Motegi, K., additional, Fujieda, T., additional, Yamato, S., additional, Doi, M., additional, Matsui, K., additional, Abe, T., additional, Katagiri, M., additional, Suzuki, M., additional, Terao, A., additional, Ishikawa, Y., additional, Tagami, T., additional, Sueta, H., additional, Doi, H., additional, Urata, M., additional, Okamoto, N., additional, Ide, F., additional, Goto, H., additional, Fujita, R., additional, Sou, Y., additional, Onga, N., additional, Takaesu, H., additional, Uehara, M., additional, Nakasone, T., additional, Yamakawa, M., additional, Horii, F., additional, Asano, I., additional, Yamaguchi, H., additional, Aoki, K., additional, Maruyama, S., additional, Ichii, M., additional, Takano, M., additional, Tsubono, Y., additional, Suzuki, K., additional, Honda, Y., additional, Yamagishi, K., additional, Sakurai, S., additional, Tsuchiya, N., additional, Kabuto, M., additional, Yamaguchi, M., additional, Matsumura, Y., additional, Sasaki, S., additional, Watanabe, S., additional, Akabane, M., additional, Kadowaki, T., additional, Inoue, M., additional, Noda, M., additional, Mizoue, T., additional, Kawaguchi, Y., additional, Takashima, Y., additional, Yoshida, Y., additional, Nakamura, K., additional, Takachi, R., additional, Ishihara, J., additional, Matsushima, S., additional, Natsukawa, S., additional, Shimizu, H., additional, Sugimura, H., additional, Tominaga, S., additional, Hamajima, N., additional, Iso, H., additional, Sobue, T., additional, Iida, M., additional, Ajiki, W., additional, Ioka, A., additional, Sato, S., additional, Maruyama, E., additional, Konishi, M., additional, Okada, K., additional, Saito, I., additional, Yasuda, N., additional, Kono, S., additional, Akiba, S., additional, Isobe, T., additional, and Sato, Y., additional

Published
2018
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24. Surgical site infection in patients with endometrial cancer undergoing open surgery.

Author

Arakaki, Y., Nakasone, T., Kinjyo, Y., Shimoji, Y., Taira, Y., Nakamoto, T., Wakayama, A., Ooyama, T., Kudaka, W., and Aoki, Y.

Subjects
*ENDOMETRIAL cancer, *SURGICAL site infections, *ENDOMETRIAL cancer risk factors, *BODY mass index, *UNIVARIATE analysis
Abstract

Purpose: Women with endometrial cancer have several risk factors for surgical site infection (SSI). The objective of this study was to determine the incidence of, and risk factors for, SSIs in endometrial carcinoma. Materials and Methods: Women with endometrial cancer who underwent primary open surgery at this institute between 2012 and 2014 were analyzed. Patients with and without SSI were compared. Results: Of all 107 patients, ten (9.3%) were diagnosed with SSI. Univariate analyses assessed age, BMI, diabetes mellitus, hypertension, postoperative body temperature, and serum albumin level as potential risk factors. There was no significant correlation between the mode of lymph node surgery and the occurrence of SSI. Multivariate analysis indicated that BMI was independently associated with a higher risk for SSI. Conclusions: Of all the tested, obesity exhibited the most significant risk factor for SSI in patients with endometrial cancer undergoing open surgery. [ABSTRACT FROM AUTHOR]

Published
2019
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27. Association of green tea consumption with mortality due to all causes and major causes of death in a Japanese population: the Japan Public Health Center-based Prospective Study (JPHC Study)

Author

Saito, Eiko, primary, Inoue, Manami, additional, Sawada, Norie, additional, Shimazu, Taichi, additional, Yamaji, Taiki, additional, Iwasaki, Motoki, additional, Sasazuki, Shizuka, additional, Noda, Mitsuhiko, additional, Iso, Hiroyasu, additional, Tsugane, Shoichiro, additional, Tsugane, S., additional, Sawada, N., additional, Iwasaki, M., additional, Sasazuki, S., additional, Yamaji, T., additional, Shimazu, T., additional, Hanaoka, T., additional, Ogata, J., additional, Baba, S., additional, Mannami, T., additional, Okayama, A., additional, Kokubo, Y., additional, Miyakawa, K., additional, Saito, F., additional, Koizumi, A., additional, Sano, Y., additional, Hashimoto, I., additional, Ikuta, T., additional, Tanaba, Y., additional, Sato, H., additional, Roppongi, Y., additional, Takashima, T., additional, Miyajima, Y., additional, Suzuki, N., additional, Nagasawa, S., additional, Furusugi, Y., additional, Nagai, N., additional, Ito, Y., additional, Komatsu, S., additional, Minamizono, T., additional, Sanada, H., additional, Hatayama, Y., additional, Kobayashi, F., additional, Uchino, H., additional, Shirai, Y., additional, Kondo, T., additional, Sasaki, R., additional, Watanabe, Y., additional, Miyagawa, Y., additional, Kobayashi, Y., additional, Machida, M., additional, Kobayashi, K., additional, Tsukada, M., additional, Kishimoto, Y., additional, Takara, E., additional, Fukuyama, T., additional, Kinjo, M., additional, Irei, M., additional, Sakiyama, H., additional, Imoto, K., additional, Yazawa, H., additional, Seo, T., additional, Seiko, A., additional, Ito, F., additional, Shoji, F., additional, Saito, R., additional, Murata, A., additional, Minato, K., additional, Motegi, K., additional, Fujieda, T., additional, Yamato, S., additional, Matsui, K., additional, Abe, T., additional, Katagiri, M., additional, Suzuki, M., additional, Doi, M., additional, Terao, A., additional, Ishikawa, Y., additional, Tagami, T., additional, Sueta, H., additional, Doi, H., additional, Urata, M., additional, Okamoto, N., additional, Ide, F., additional, Goto, H., additional, Onga, N., additional, Takaesu, H., additional, Uehara, M., additional, Nakasone, T., additional, Yamakawa, M., additional, Horii, F., additional, Asano, I., additional, Yamaguchi, H., additional, Aoki, K., additional, Maruyama, S., additional, Ichii, M., additional, Takano, M., additional, Tsubono, Y., additional, Suzuki, K., additional, Honda, Y., additional, Yamagishi, K., additional, Sakurai, S., additional, Tsuchiya, N., additional, Kabuto, M., additional, Yamaguchi, M., additional, Matsumura, Y., additional, Sasaki, S., additional, Watanabe, S., additional, Akabane, M., additional, Kadowaki, T., additional, Inoue, M., additional, Noda, M., additional, Mizoue, T., additional, Kawaguchi, Y., additional, Takashima, Y., additional, Yoshida, Y., additional, Nakamura, K., additional, Takachi, R., additional, Ishihara, J., additional, Matsushima, S., additional, Natsukawa, S., additional, Shimizu, H., additional, Sugimura, H., additional, Tominaga, S., additional, Hamajima, N., additional, Iso, H., additional, Sobue, T., additional, Iida, M., additional, Ajiki, W., additional, Ioka, A., additional, Sato, S., additional, Maruyama, E., additional, Konishi, M., additional, Okada, K., additional, Saito, I., additional, Yasuda, N., additional, Kono, S., additional, and Akiba, S., additional

Published
2015
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28. Adjuvant docetaxel and carboplatin chemotherapy for patients with high-intermediate and high-risk endometrial cancer.

Author

Kudaka, W., Nakasone, T., Arakaki, Y., Nakamoto, T., Wakayama, A., Kinjyo, Y., Taira, Y., Nagai, Y., Kaneshima, I., Nishihira, K., and Aoki, Y.

Subjects
*DOCETAXEL, *CARBOPLATIN, *CANCER chemotherapy, *ENDOMETRIAL cancer, *ADJUVANT treatment of cancer
Abstract

Purpose: A phase II study was conducted to confirm the efficacy and toxicity of docetaxel and carboplatin in patients with high-intermediate and high-risk endometrial cancer in an adjuvant setting. Materials and Methods: Eligible women had histologically verified endometrioid adenocarcinoma and Stage IC/IIG3 with deep myometrial invasion or Stage III disease. Docetaxel 70 mg/m² and carboplatin AUC 5 were administered every three weeks for six cycles. The primary end point was to evaluate the five-year PFS rate and the secondary end point was to assess adverse events. Results: The five-year OS rate was 90.8% while the five-year DFS rate was 85.4%. Because of the hypersensitivity reactions, chemotherapy regimen was changed in two patients, and the protocol therapy was discontinued in two patients by patient’s will after two cycles and four cycles, respectively. Conclusion: Docetaxel and carboplatin combination chemotherapy may be one of the applicable adjuvant treatments for this group of patients. [ABSTRACT FROM AUTHOR]

Published
2017
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29. Protective immune responses induced by secretion of a chimeric soluble protein from a recombinant Mycobacterium bovis bacillus Calmette-Guérin vector candidate vaccine for human immunodeficiency virus type 1 in small animals

Author

Yamazaki S, Y. Fukushima, Watanabe K, Kitamura K, Mitsuo Honda, Keitaro Matsuo, K. Komuro, Nakasone T, Taketo Yamada, Sugiura W, Asano T, Yamazaki A, Yoshimoto Katsura, Haga S, Tasaka H, Okamoto Y, and Yoshizaki H

Subjects
Genetic Vectors, Guinea Pigs, Molecular Sequence Data, Enzyme-Linked Immunosorbent Assay, HIV Infections, Mice, SCID, Biology, HIV Envelope Protein gp120, Antibodies, Viral, Peripheral blood mononuclear cell, Epitope, Mice, Viral Proteins, Immune system, Neutralization Tests, medicine, Cytotoxic T cell, Animals, Humans, Amino Acid Sequence, Skin Tests, Antiserum, AIDS Vaccines, Severe combined immunodeficiency, Mycobacterium bovis, Vaccines, Synthetic, Multidisciplinary, Base Sequence, Immunization, Passive, Middle Aged, medicine.disease, biology.organism_classification, Virology, Peptide Fragments, Immunization, HIV-1, Research Article, T-Lymphocytes, Cytotoxic
Abstract

A recombinant Mycobacterium bovis bacillus Calmette-Guérin (BCG) vector-based vaccine that secretes the V3 principal neutralizing epitope of human immunodeficiency virus (HIV) could induce immune response to the epitope and prevent the viral infection. By using the Japanese consensus sequence of HIV-1, we successfully constructed chimeric protein secretion vectors by selecting an appropriate insertion site of a carrier protein and established the principal neutralizing determinant (PND)-peptide secretion system in BCG. The recombinant BCG (rBCG)-inoculated guinea pigs were initially screened by delayed-type hypersensitivity (DTH) skin reactions to the PND peptide, followed by passive transfer of the DTH by the systemic route. Further, immunization of mice with the rBCG resulted in induction of cytotoxic T lymphocytes. The guinea pig immune antisera showed elevated titers to the PND peptide and neutralized HIVMN, and administration of serum IgG from the vaccinated guinea pigs was effective in completely blocking the HIV infection in thymus/liver transplanted severe combined immunodeficiency (SCID)/hu or SCID/PBL mice. In addition, the immune serum IgG was shown to neutralize primary field isolates of HIV that match the neutralizing sequence motif by a peripheral blood mononuclear cell-based virus neutralization assay. The data support the idea that the antigen-secreting rBCG system can be used as a tool for development of HIV vaccines.

Published
1995

39. Protective immune responses induced by secretion of a chimeric soluble protein from a recombinant Mycobacterium bovis bacillus Calmette-Guérin vector candidate vaccine for human immunodeficiency virus type 1 in small animals.

Author

Honda, M, primary, Matsuo, K, additional, Nakasone, T, additional, Okamoto, Y, additional, Yoshizaki, H, additional, Kitamura, K, additional, Sugiura, W, additional, Watanabe, K, additional, Fukushima, Y, additional, and Haga, S, additional

Published
1995
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40. Human T-lymphotropic virus type II in Vietnam

Author

D.D. Dao, K. Komuro, Honda M, S. Nakata, Nakasone T, Y. Fukushima, and S. Pham

Subjects
Vietnam, biology, Case-Control Studies, Population Surveillance, HTLV-II Infections, Humans, General Medicine, Human T-lymphotropic virus, Substance Abuse, Intravenous, biology.organism_classification, Virology
Published
1994
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41. Induction of CD95 ligand expression on T lymphocytes and B lymphocytes and its contribution to apoptosis of CD95-up-regulated CD4+ T lymphocytes in macaques by infection with a pathogenic simian/human immunodeficiency virus.

Author

Sasaki, Y., Ami, Y., Nakasone, T., Shinohara, K., Takahashi, E., Ando, S., Someya, K., Suzaki, Y., and Honda, M.

Subjects
APOPTOSIS, SIMIAN viruses, HIV, T cells, LIGANDS (Biochemistry)
Abstract

Using an established SIV/HIV-C2/1-infected cynomolgus monkey model displaying stable CD4+ T cell depletion, the kinetics of apoptosis and the levels of expression of CD95 membrane-associated CD95L on lymphocytes were investigated to test the involvement of the CD95/CD95L system in CD4+ T lymphocyte loss in vivo. Rapid depletion of CD4+ T cells occurred up to 2 weeks after infection, with chronic CD4+ T lymphopenia thereafter. During the initial CD4+ T cell loss, which was accompanied by viraemia, about 90% of the peripheral CD4+ T cell subset underwent spontaneous apoptotic cell death during 24 h of culture. Increased expression of CD95 was observed on both CD4+ and CD8+ T cell subsets, with CD95 expression on CD8+ cells declining rapidly, but high CD95 expression being maintained on CD4+ cells. Since CD95L was expressed on CD8+ T cells, B cells and to a lesser extent on CD4+ T cells, this suggests that CD95-mediated apoptosis might be controlled in an autocrine/paracrine fashion. [ABSTRACT FROM AUTHOR]

Published
2000
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43. Orthopedics & Traumatology

Author

Ibaraki, K., primary, Takara, H., additional, Kayo, M., additional, Inoue, O., additional, Uezato, H., additional, Arakaki, A., additional, Nakasone, T., additional, and Uezato, T., additional

Published
1982
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44. Orthopedics & Traumatology

Author

Takara, H., primary, Ibaraki, K., additional, Kayo, M., additional, Inoue, O., additional, Arakaki, A., additional, Oroku, H., additional, and Nakasone, T., additional

Published
1982
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46. Assessment of individual external exposure doses based on environmental radiation in areas affected by the Fukushima Daiichi Nuclear Power Station accident.

Author

Sato R, Yoshimura K, Sanada Y, Mikami S, Yamada T, Nakasone T, Kanaizuka S, Sato T, Mori T, and Takagi M

Subjects
Humans, Japan, Radiation Dosage, Radiation Exposure, Environmental Exposure analysis, Models, Theoretical, Fukushima Nuclear Accident, Radiation Monitoring methods
Abstract

Assessing individual external exposure doses from ambient dose equivalents is valuable for predictive and retrospective purposes when personal dosimeters are impractical. This study developed a model to assess individual external exposure doses from ambient dose equivalents, considering daily life patterns (location and time spent in various places), and evaluated parameters associated with individual external exposure doses, such as the reduction effects of radiation due to buildings and vehicles. The model parameters were evaluated using the robust datasets of environmental radiation measured in areas affected by the Fukushima Daiichi Nuclear Power Station (FDNPS) accident. The effective dose estimated by the model was compared to 106 daily personal dose equivalents measured using personal dosimeters in the residents' living environments near the FDNPS. The estimated effective dose well consists with the measured personal dose equivalents, particularly when considering natural radiation in indoor dose estimation. This model is adequate for radiation protection, enabling the predictive and retrospective estimation of individual external exposure doses using environmental radiation monitoring data., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Published
2024
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47. Cordyceps militaris fruit body activates myeloid dendritic cells via a Dectin-1-mediated pathway.

Author

Kanno T, Tada R, Nakasone T, Okamatsu S, Iwakura Y, Tamura K, Miyaoka H, and Adachi Y

Subjects
Animals, Mice, Fruiting Bodies, Fungal, Cytokines metabolism, Signal Transduction immunology, Myeloid Cells immunology, Myeloid Cells metabolism, beta-Glucans pharmacology, beta-Glucans immunology, Cordyceps, Lectins, C-Type immunology, Lectins, C-Type metabolism, Dendritic Cells immunology, Dendritic Cells drug effects, Mice, Knockout, Mice, Inbred C57BL
Abstract

Cordyceps militaris, an entomopathogenic fungus, has been traditionally used in East Asian medicine. Recent research indicates that the fruit bodies of C. militaris are rich in bioactive compounds, such as polysaccharides and nucleosides, which may offer health benefits. However, the specific components responsible for its immunostimulatory effects and the mechanisms involved remain unclear. This study explored the immunomodulatory activity of a fruit body extract from C. militaris, named Ryukyu-kaso (RK), and examined the effect of the β-glucan receptor Dectin-1 on bone marrow-derived dendritic cells (BMDCs). Our results demonstrated that RK, which contains 1,3-β-glucan, effectively stimulated BMDCs to secrete pro-inflammatory and immunoregulatory cytokines and upregulated surface markers indicative of maturation and activation. Notably, these immunostimulatory effects were completely absent in BMDCs derived from Dectin-1-knockout mice, confirming that Dectin-1 is crucial for RK-induced immunomodulation. These findings provide new insights into the immunostimulatory mechanisms of C. militaris and underscore the potential of RK as a natural immunomodulatory agent for various therapeutic applications., Competing Interests: Declaration of Competing Interest Toyokazu Nakasone and Shigemi Okamatsu are employees of Okinawa UKAMI Sericulture Co. Ltd. Takashi Kanno, Rui Tada, Yoichiro Iwakura, Kazuhiro Tamura, Hiroaki Miyaoka, and Yoshiyuki Adachi declare no conflicts of interest., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Published
2024
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48. Transcatheter Arterial Embolization for Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Retrospective Study of 44 Patients.

Author

Kubo T, Shibuya M, Miyazaki K, Tsuji Y, Nakata M, Kawabe A, Nakasone T, Sakai N, and Okuno Y

Subjects
Humans, Male, Retrospective Studies, Adult, Middle Aged, Treatment Outcome, Chronic Pain therapy, Pain Measurement, Aged, Prostate blood supply, Embolization, Therapeutic methods, Prostatitis therapy, Prostatitis complications, Pelvic Pain therapy
Abstract

Purpose: To investigate the preliminary treatment outcomes of transcatheter arterial embolization (TAE) for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)., Materials and Methods: This retrospective study included patients with refractory CP/CPPS who underwent TAE between April 2022 and February 2023. All patients had persistent pelvic pain for at least 3 months, a total score of at least 15 on the NIH-Chronic Prostatitis Symptom Index (NIH-CPSI), and lacked evidence of infection. All procedures were performed by injecting imipenem/cilastatin sodium (IPM/CS) from bilateral prostatic arteries ± internal pudendal arteries. NIH-CPSI, pain numeric rating scale (NRS), and complications were evaluated at 1, 3, and 6 months after the initial TAE and at the final follow-up., Results: Out of 48 patients, 44 were included in this study, with four excluded because of loss of follow-up. No severe procedure-related complications were observed. Pretreatment and post-treatment evaluations at 1, 3, and 6 months after the initial TAE and at the final follow-up (mean 16.6 months) revealed a decrease in the mean NIH-CPSI scores from 27 ± 6 to 21 ± 8, 20 ± 9, 17 ± 9, and 18 ± 9, respectively (all P < 0.001). Pain NRS scores were also decreased from 7.0 ± 1.6 to 4.8 ± 2.5, 4.1 ± 2.6, 3.7 ± 2.4, and 3.4 ± 2.3, respectively (all P < 0.001). The proportions of clinical success, defined as a reduction of at least 6 points from baseline in the NIH-CPSI, at 6 months after TAE and at the final follow-up were 70 and 64%, respectively., Conclusions: This study provides evidence of the feasibility of TAE using IPM/CS for CP/CPPS, suggesting both symptomatic improvement and safety., (© 2024. Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE).)

Published
2024
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49. Clinical results of ultrasound-guided intra-arterial embolization targeting abnormal neovessels for plantar fasciitis: 66 cases with up to 4 years of follow-up.

Author

Sasaki T, Shibuya M, Miyazaki K, Nakata M, Kawabe A, Nakasone T, Sakai N, and Okuno Y

Abstract

Background: Plantar fasciitis (PF) is the most common cause of chronic heel pain, affecting young and older patients., Methods: This retrospective study included patients with PF refractory to conservative treatment who underwent intra-arterial embolization of abnormal neovessels. All patients received temporary embolic material through a needle percutaneously inserted into the posterior tibial artery. The numeric rating scale (NRS) pain score, American Orthopaedic Foot and Ankle Society (AOFAS) score, and procedure-related adverse events were evaluated., Results: Between January 2020 and February 2022, 66 patients with PF were treated with intra-arterial embolization without major adverse events. The NRS pain score improved significantly, and the AOFAS score increased from 65.8 pre-treatment to 92.8 at 1 year post-treatment. The treatment effect was maintained until the final follow-up (mean duration: 30.9 months)., Conclusions: Ultrasound-guided intraarterial embolization using temporary embolic material may be effective for PF., Level of Evidence: IV., Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Yuji Okuno has received consulting fees from Asahi Intecc and lecture fees from Terumo and Daiichi Sankyo outside the submitted work. The rest of the authors declare no conflicts of interest., (Copyright © 2024 European Foot and Ankle Society. Published by Elsevier Ltd. All rights reserved.)

Published
2024
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50. Hot Water Extract of the Caterpillar Medicinal Mushroom Cordyceps militaris (Ascomycetes) Fruiting Body Activates Myeloid Dendritic Cells through A Dectin-1-Mediated Pathway.

Author

Kanno T, Tada R, Nakasone T, Okamatsu S, Iwakura Y, Tamura K, Miyaoka H, and Adachi Y

Subjects
Animals, Mice, Mice, Inbred C57BL, Water chemistry, Immunologic Factors pharmacology, Dendritic Cells drug effects, Dendritic Cells immunology, Cordyceps chemistry, Lectins, C-Type metabolism, Lectins, C-Type genetics, Fruiting Bodies, Fungal chemistry, Cytokines metabolism, beta-Glucans pharmacology
Abstract

The traditional use of Cordyceps militaris, an entomopathogenic fungus, in East Asian medicine has been well documented. Our previous study revealed that the fruiting body powder of C. militaris, referred to as Ryukyu-kaso, contains 1,3-β-glucan and stimulates bone marrow-derived dendritic cells via a dectin-1-dependent pathway. However, the immunomodulatory effects of soluble 1,3-β-glucan in Ryukyu-kaso and the underlying mechanisms remain unclear. In the present study, we aimed to investigate the immunostimulatory effects of the hot water extract of C. militaris fruiting body (RK-HWE) on bone marrow-derived dendritic cells and the involvement of the β-glucan receptor dectin-1. Our findings revealed that the hot water extract of C. militaris fruiting body contains soluble 1,3-β-glucan and potently induces bone marrow-derived dendritic cells to secrete both pro-inflammatory and immunoregulatory cytokines. Compared with the control, RK-HWE significantly increased the secretion of tumor necrosis factor (TNF)-α, interleukin (IL)-6, interfer-on-в, IL-12p70, and granulocyte-macrophage colony-stimulating factor (all ,i>p < 0.05), with TNF-α secretion increasing from 7.82 ± 1.57 (control) to 403.7 ± 59.7 pg/mL with (RK-HWE; p < 0.001). Notably, these immunostimulatory effects of RK-HWE were completely abolished in bone marrow-derived dendritic cells derived from dectin-1-knockout mice (p < 0.001, all cytokines), suggesting that dectin-1 is essential for immunomodulation induced by RK-HWE. These findings provide novel insights into the mechanisms underlying the immunostimulatory effects of RK-HWE and highlight its potential as a natural immunomodulatory agent for various therapeutic applications.

Published
2024
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