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869 results on '"Nakaya, Yutaka"'

3. Predictors for the Treatment Effect of Sodium Glucose Co-transporter 2 Inhibitors in Patients with Type 2 Diabetes Mellitus

Author

Yagi, Shusuke, Aihara, Ken-ichi, Kondo, Takeshi, Kurahashi, Kiyoe, Yoshida, Sumiko, Endo, Itsuro, Fukuda, Daiju, Nakaya, Yutaka, Suwaki, Kin-ichiro, Takeji, Takashi, Wada, Toshihiro, Salim, Hotimah Masdan, Hama, Saori, Matsuura, Tomomi, Ise, Takayuki, Kusunose, Kenya, Yamaguchi, Koji, Tobiume, Takeshi, Yamada, Hirotsugu, Soeki, Takeshi, Wakatsuki, Tetsuzo, Matsuhisa, Munehide, Shimabukuro, Michio, Akaike, Masashi, and Sata, Masataka

Published
2017
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10. Saturated fatty acids intake is associated with muscle atrophy in rheumatoid arthritis

Author

Sebe, Mayu, primary, Tsutsumi, Rie, additional, Senoura, Satoka, additional, Kishi, Jun, additional, Iuchi, Marina, additional, Mishima, Yuna, additional, Tsutsumi, Yasuo M., additional, Kuroda, Masashi, additional, Harada, Nagakatsu, additional, Nakaya, Yutaka, additional, Kinoshita, Seizo, additional, Nishioka, Yasuhiko, additional, and Sakaue, Hiroshi, additional

Published
2021
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23. BCAA-enriched snack improves nutritional state of cirrhosis

Author

Nakaya, Yutaka, Okita, Kiwamu, Suzuki, Kazuyuki, Moriwaki, Hisataka, Kato, Akinobu, Miwa, Yoshiyuki, Shiraishi, Koichi, Okuda, Hiroaki, Onji, Morikazu, Kanazawa, Hidenori, Tsubouchi, Hirohito, Kato, Shinzo, Kaito, Masahiko, Watanabe, Akiharu, Habu, Daiki, Ito, Susumu, Ishikawa, Tomohisa, Kawamura, Naohiro, and Arakawa, Yasuyuki

Published
2007
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25. Distinct Gene Expression Profile Distinguishes Increased Metabolic Activity in Spontaneously Hyperactive Rats While Sedentary from That Induced by Exercise

Author

Abe, Manami, Matsuo, Yuki, Harada-Sukeno, Akiko, Uchida, Takayuki, Kitahata, Kanako, Tomida, Chisato, Hirasaka, Katsuya, Teshima-Kondo, Shigetada, Harada, Nagakatsu, Nakaya, Yutaka, Sakaue, Hiroshi, Nakao, Reiko, and Nikawa, Takeshi

Subjects
mitochondria, myofiber type, human activities, microarray, metabolism
Abstract

The Spontaneously-Running Tokushima Shikoku (SPORTS) strain is an original line derived from Wistar rats, which spontaneously runs >6 km/day on wheels, and has better glucose tolerance and less fat than Wistar rats. However, the molecular mechanism that contributes to the increased metabolic activity in SPORTS rats is unknown. The present study aimed to characterize the gene expression profiles of skeletal muscles in SPORTS rats housed under sedentary (SED) conditions. We found that the expression levels of genes encoding mitochondrial respiratory chain enzymes such as ATP synthase 6 (mt-Atp6) and cytochrome c oxidase subunit 6c (Cox 6c), were higher in the soleus (SOL) muscles of SED SPORTS than in SED Wistar rats. The ratio of type IIa myofibers was higher and glucose tolerance was better in SED SPORTS than in Wistar rats that were sedentary and trained daily on treadmills, respectively. We then investigated candidate genes that might contribute to the better glucose tolerance of SED SPORTS rats using DNA microarray analysis. Among 116 upregulated genes in the SOL muscles of SED SPORTS rats, only 19 were also increased in trained Wistar rats. We focused on v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (Erbb3), which was associated with glucose transport in myocytes, and found higher expression levels in the SOL muscles of SED SPORTS than in SED Wistar rats. The SOL muscles of SED SPORTS rats also contained more activity of β-hydroxy-acylCoA dehydrogenase, a key enzyme of β-oxidation, indicating enhanced lipid oxidation. These findings suggest that increased metabolic activity in skeletal muscle (especially the SOL muscle) of SPORTS rats is congenital and that gene expression profiles of SPORTS rats and Trained Wistar rats are different.

Published
2018

27. Human airway trypsin-like protease stimulates human bronchial fibroblast proliferation in a protease-activated receptor-2-dependent pathway

Author

Matsushima, Rie, Takahashi, Akira, Nakaya, Yutaka, Maezawa, Hiroshi, Miki, Mari, Nakamura, Yoichi, Ohgushi, Fumitaka, and Yasuoka, Susumu

Subjects
Protein kinases -- Research, Proteases -- Research, Fibroblasts -- Research, Mast cells -- Research, Biological sciences
Abstract

Human airway trypsinlike protease (HAT) was isolated from airway secretions and localized to bronchial epithelial cells by immunohistochemistry. In the present study, we examined whether HAT could stimulate DNA synthesis and proliferation of primary human bronchial fibroblasts (HBF). HAT significantly stimulated the proliferation of HBF by 20-55%, a level similar to that of the mitogenic activity of lung mast cell tryptase (MCT). HAT also stimulated the incorporation of [[sup.3]H]thymidine in HBF, and this HAT-induced DNA synthesis was abolished by leupeptin. Protease-activated receptor-2 (PAR-2) mRNA was expressed and localized to the cell surface in HBF. PAR-2 activating peptide (AP) also enhanced DNA synthesis, and both HAT and PAR-2 AP induced receptor internalization, similar to the response to trypsin. Pretreatment of HBF with anti-PAR-2 antibody significantly suppressed both HAT and PAR-2 AP-induced DNA synthesis. In addition, HAT and PAR-2 AP induced intracellular [Ca.sup.2+] mobilization in HBF. The HAT-induced increase in [Ca.sup.2+] was desensitized by pretreatment with trypsin or PAR-2 AP. U0126, a specific MAPK inhibitor, completely inhibited HAT-induced DNA synthesis as well as HAT-induced phosphorylation of MAPK. The effect of HAT and MCT together was additive, whereas the effect of HAT and insulin together on HBF DNA synthesis was synergistic. These results indicate that HAT stimulates fibroblast proliferation in bronchial airways through a PAR-2-dependent MEK-MAPK mediated pathway and that HAT is linked to airway processes involving fibroblasts. mast cell tryptase; mitogen-activated protein kinase

Published
2006

50. Mismatch between myocardial accumulation of 123 I-MIBG and 99m Tc-MIBI and late ventricular potentials in patients after myocardial infarction: Association with the development of ventricular arrhythmias

Author

Yukinaka, Michiko, Nomura, Masahiro, Ito, Susumu, and Nakaya, Yutaka

Subjects
Arrhythmia, Heart attack, Cardiac patients, Health
Abstract

Byline: Michiko Yukinaka, Masahiro Nomura, Susumu Ito, Yutaka Nakaya Abstract: Background Late ventricular potentials are widely used to predict life-threatening arrhythmias, although the predictive value is low. To improve prediction, we correlated the incidence of ventricular arrhythmias with mismatches in myocardial.sup.99m Tc-methoxyisobutylisonitrile (MIBI)/.sup.123 I-metaiodobenzylguanidine (MIBG) accumulation and late ventricular potentials (LP). Methods and Results Fifty patients with old myocardial infarctions were divided into an LP-positive group (n = 19) and an LP-negative group (n = 31). On bull's-eye single photon emission computed tomographic MIBI and MIBG images, the heart was divided into 9 segments to evaluate the accumulation of the 2 nuclides. There was no difference in total defect score (TDS) for MIBI between the LP-positive and LP-negative groups. However, TDS for MIBG and differences TDS between MIBI and MIBG ([DELTA]TDS) were significantly greater in the LP-positive group. Conclusions The incidence of severe ventricular arrhythmias was greater among patients with an increased [DELTA]TDS in the LP-positive group. Thus the combination of these two methods may improve the prediction of ventricular arrhythmias after myocardial infarction. (Am Heart J 1998;136:859-67.) Author Affiliation: Tokushima, Japan Article History: Received 4 October 1997; Accepted 28 March 1998 Article Note: (footnote) [star] From the a Second Department of Internal Medicine and the b Department of Nutrition, School of Medicine, University of Tokushima., [star][star] Reprint requests: Michiko Yukinaka, MD, Second Department of Internal Medicine, University of Tokushima, 2-50 Kuramoto-cho, Tokushima City, 770-8503 Japan., a 4/1/90410

Published
1998

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