Search

Red Geysers are quiescent galaxies with galactic scale ionised outflows, likely due to low-luminosity Active Galactic Nuclei (AGN). We used Gemini GMOS-IFU observations of the inner $\sim 1.0-3.0$ kpc of nine Red Geysers selected from the MaNGA survey to study the gas ionisation and kinematics. The emission-line ratios suggest the presence of Seyfert/LINER (Low Ionisation Nuclear Emission Region) nuclei in all sources. Two galaxies show H$\alpha$ equivalent width (H$\alpha$ EW) larger than 3 \AA (indicative of AGN ionisation) within an aperture 2.5 arcsec of diameter ($1.3-3.7$ kpc at the distance of galaxies) for MaNGA data, while with the higher resolution GMOS data, four galaxies present H$\alpha$ EW$>3$ \AA within an aperture equal to the angular resolution ($0.3-0.9$ kpc). For two objects with GMOS-IFU data, the H$\alpha$ EW is lower than 3 \AA but larger than 1.5 \AA, most probably due to a faint AGN. The spatially resolved electron density maps show values between $100-3000$ cm$^{-3}$ and are consistent with those determined in other studies. The large (MaNGA) and the nuclear scale (GMOS-IFU) gas velocity fields are misaligned, with a kinematic position angle difference between 12$^{\circ}$ and 60$^{\circ}$. The [NII]$\lambda$6583 emission-line profiles are asymmetrical, with blue wings on the redshifted side of the velocity field and red wings on the blueshifted side. Our results support previous indications that the gas in Red Geysers is ionised by an AGN, at least in their central region, with the presence of outflows, likely originating in a precessing accretion disc., Comment: Accepted for publication in August 3, 2022

In the first billion years after the Big Bang, sources of ultraviolet (UV) photons are believed to have ionized intergalactic hydrogen, rendering the Universe transparent to UV radiation. Galaxies brighter than the characteristic luminosity $L^{*}$ do not provide enough ionizing photons to drive this cosmic reionization. Fainter galaxies are thought to dominate the photon budget; however they are surrounded by neutral gas that prevents the escape of the Lyman-$\alpha$ photons, which has been the dominant way to identify them so far. JD1 was previously identified as a triply-imaged galaxy with a magnification factor of 13 provided by the foreground cluster Abell 2744, and a photometric redshift of $z\sim10$. Here we report the spectroscopic confirmation of this very low luminosity ($\sim0.05 L^{*}$) galaxy at $z=9.79$, observed 480 Myr after the Big Bang, by means of the identification of the Lyman break and redward continuum, as well as multiple $\gtrsim4\sigma$ emission lines, with the Near-InfraRed Spectrograph (NIRSpec) and Near-InfraRed Camera (NIRCam) instruments. The combination of the James Webb Space Telescope (JWST) and gravitational lensing shows that this ultra-faint galaxy ($M_{\rm UV}=-17.35$) -- with a luminosity typical of the sources responsible for cosmic reionization -- has a compact ($\sim$150 pc) and complex morphology, low stellar mass (10$^{7.19}$ M$_\odot$), and subsolar ($\sim$0.6 $Z_{\odot}$) gas-phase metallicity., Comment: Matched to the published Nature version of the article. 19 pages, 4 main figures, 1 supplementary figure, 1 supplementary tables. This version includes an updated version of the NIRSpec spectrum and NIRCam photometry

JWST observations confirm the existence of galaxies as early as 300Myr and at a higher number density than expected based on galaxy formation models and HST observations. Yet, sources confirmed spectroscopically in the first 500Myr have estimated stellar masses $8$, we identify evidence of absorption lines (Si, C and Fe), with low confidence individual detections but SNR$>6$ when stacked. The absorption features suggest that Ly$α$ is damped by the interstellar and circumgalactic medium. Our observations provide evidence of rapid efficient build-up of mass and metals in the immediate aftermath of the Big Bang through mergers, demonstrating that massive galaxies with several billion stars exist earlier than expected., 52 pages, 10 figures

We study the spatially resolved stellar populations of 444 galaxies at $0.3, Comment: 31 pages, 18 figures, accepted for publication in ApJ. Some examples and tutorials of spatially resolved SED analysis will be available at https://github.com/aabdurrouf/JWST-HST_resolvedSEDfits

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, known as coronavirus disease 2019 (COVID-19) causes cytokine release syndrome (CRS), leading to acute respiratory distress syndrome (ARDS), acute kidney and cardiac injury, liver dysfunction, and multiorgan failure. Although several studies have discussed the role of 5-lipoxygenase (5-LOX) in viral infections, such as influenzae and SARS, it remains unexplored in the pathophysiology of COVID-19. 5-LOX acts on free arachidonic acid (AA) to form proinflammatory leukotrienes (LTs). Of note, numerous cells involved with COVID-19 (e.g., inflammatory and smooth muscle cells, platelets, and vascular endothelium) widely express leukotriene receptors. Moreover, 5-LOX metabolites induce the release of cytokines (e.g., tumour necrosis factor-α [TNF-α], interleukin-1α [IL-1α], and interleukin-1β [IL-1β]) and express tissue factor on cell membranes and activate plasmin. Since macrophages, monocytes, neutrophils, and eosinophils can express lipoxygenases, activation of 5-LOX and the subsequent release of LTs may contribute to the severity of COVID-19. This review sheds light on the potential implications of 5-LOX in SARS-CoV-2-mediated infection and the anticipated therapeutic role of 5-LOX inhibitors.

We find 132 face-on and low inclination galaxies with central star formation driven biconical gas outflows (FSFB) in the SDSS MaNGA (Mapping Nearby Galaxies at APO) survey. The FSFB galaxies show either double peaked or broadened emission line profiles at their centres. The peak and maximum outflow velocities are 58 and 212 km/s, respectively. The gas velocity dispersion reveals a mild dependence on the central star formation surface density compatible with models of gas dispersion powered by the Jeans instability in gas clumps or by gas turbulence dissipation. We estimate the gas outflow rate and conclude that the central gas depletion time does not depend on galactic mass. In turn, the ratio of the gas outflow rate to the gas consumption rate by the star formation is low in massive galaxies and high in low-mass objects, while the star formation is a more rapid process of the gas consumption. We compare properties of the FSFB galaxies with a control sample of 375 comparison galaxies and find that the FSFB objects have high central concentration of star formation, and also younger central stellar population with respect to their periphery. We analysed the environment of the galaxies and identified nearby satellites and elements of low surface brightness structure. We see that many tidal-enhanced features that can be assigned to early and intermediate stages of galactic interaction are much more frequent in the FSFB galaxies with respect to the comparison sample. We conclude that the gas should be replenished via the accretion from small satellites., 12 pages, 15 figures. Accepted for publication in MNRAS

Healthy progression of human pregnancy relies on cytotrophoblast progenitor (CTB) self-renewal and their differentiation towards multi-nucleated syncytiotrophoblasts (STBs) and invasive extravillous trophoblasts (EVTs). However, underlying molecular mechanisms that fine-tune CTB self-renewal or direct their differentiation towards STBs or EVTs during human placentation are poorly defined. Here, we show that hippo signaling cofactor WW Domain Containing Transcription Regulator 1 (WWTR1) is a master regulator of trophoblast fate choice during human placentation. Using human trophoblast stem cells (human TSCs), primary CTBs and human placental explants, we demonstrate that WWTR1 promotes self-renewal in human CTBs and is essential for their differentiation to EVTs. In contrast, WWTR1 prevents induction of STB fate in undifferentiated CTBs. Our single-cell RNA-sequencing analyses in first-trimester human placenta along with mechanistic analyses in human TSCs revealed that WWTR1 fine-tunes trophoblast fate by directly regulating Wnt signaling components. Importantly, our analyses of placentae from pathological pregnancies show that extreme preterm birth (gestational time ≤28weeks) and intrauterine growth restriction along with preeclampsia (IUGR/PE) are often associated with loss of WWTR1 expression in CTBs. In summary, our findings establish a critical importance of WWTR1 at the crossroads of human trophoblast progenitor self-renewal vs. differentiation. It plays positive instructive roles to promote CTB self-renewal and EVT differentiation and safeguards undifferentiated CTBs from obtaining the STB fate.SIGNIFICANCEHuman pregnancy relies on formation of the transient organ placenta and trophoblast cells are the major building blocks of the placenta. A defect in trophoblast progenitor self-renewal or their differentiation is associated with either pregnancy loss or pathological pregnancies, yet underlying molecular mechanisms that regulate trophoblast differentiation are poorly understood. In this study, we discovered that WWTR1, a transcription cofactor and a component of conserved Hippo signaling pathway, optimizes trophoblast progenitor self-renewal and is essential for their differentiation into the invasive extravillous trophoblast cell lineage. Our findings establish WWTR1 as a critical regulator for success in human placentation and progression of a healthy pregnancy.

Since August 2020, a growing number of confirmed SARS-CoV-2 cases, after approximately three months, in most of them, again presented a new infection episode, which has been defined as reinfection. So far, no cases have been reported in Nepal, and still there is limited the number of them, especially of those fully confirmed. Here, we report a case and discuss its multiple implications in the ongoing COVID-19 pandemic.

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the cytokine release syndrome (CRS) and leads to multiorgan dysfunction. Mitochondrial dynamics are fundamental to protect against environmental insults, but they are highly susceptible to viral infections. Defective mitochondria are potential sources of reactive oxygen species (ROS). Infection with SARS-CoV-2 damages mitochondria, alters autophagy, reduces nitric oxide (NO), and increases both nicotinamide adenine dinucleotide phosphate oxidases (NOX) and ROS. Patients with coronavirus disease 2019 (COVID-19) exhibited activated toll-like receptors (TLRs) and the Nucleotide-binding and oligomerization domain (NOD-), leucine-rich repeat (LRR-), pyrin domain-containing protein 3 (NLRP3) inflammasome. The activation of TLRs and NLRP3 by SARS‐CoV‐2 induces interleukin 6 (IL-6), IL-1β, IL-18, and lactate dehydrogenase (LDH). Herein, we outline the inflammatory circuit of COVID-19 and what occurs behind the scene, the interplay of NOX/ROS and their role in hypoxia and thrombosis, and the important role of ROS scavengers to reduce COVID-19-related inflammation.

Red geysers are a specific type of quiescent galaxy, denoted by twin jets emerging from their galactic centers. These bisymmetric jets possibly inject energy and heat into the surrounding material, effectively suppressing star formation by stabilizing cool gas. In order to confirm the presence and evolutionary consequences of these jets, this paper discusses the scaling, stacking, and conversion of 21-cm HI flux data sourced from the HI-MaNGA survey into HI gas-to-stellar mass (G/S) spectra. Our samples were dominated by non-detections, or galaxies with weak HI signals, and consequently by HI upper limits. The stacking technique discussed successfully resolved emission features in both the red geyser G/S spectrum and the control sample G/S spectrum. From these stacked spectra, we find that on average, red geyser galaxies have G/S of 0.086 $\pm$ 0.011(random)+0.029(systematic), while non-red geyser galaxies of similar stellar mass have a G/S ratio of 0.039 $\pm$ 0.018(random)+0.013(systematic). Therefore, we find no statistically significant evidence that the HI content of red geysers is different from the general quiescent population., Comment: 7 pages, 5 figures, to be published in MNRAS

The demographics of the production and escape of ionizing photons from UV-faint early galaxies is a key unknown in discovering the primary drivers of reionization. With the advent of JWST it is finally possible to observe the rest-frame optical nebular emission from individual sub-L$^*$ z>3 galaxies to measure the production of ionizing photons, $\xi_\mathrm{ion}$. Here we study a sample of 370 z~3-7 galaxies spanning -23 0.5) in our sample, based on their photometric properties, even amongst the Lyman-alpha selected galaxies. This work demonstrates that considering the full distribution of $\xi_\mathrm{ion}$ across galaxy properties is important for assessing the primary drivers of reionization., Comment: 10 pages, 7 figures, submitted to A&A

In the present study, ZnO-Fe

The use of optical fibers in astronomical instrumentation offers high-multiplex and light-gathering flexibility. However, with most previous fiber spectrographs optimized for large fields of view on modest-aperture telescopes, the performance of fibers in the context of faint targets on large telescopes remains largely untested. In this paper, we evaluate aspects of fiber stability, especially as they apply in the context of precision sky subtraction of faint sources at modest spectral resolution (R ∼ 3000). After introducing a framework for describing potential systematic errors, we use publicly available data from existing instruments, including instrumentation used by the fourth-generation Sloan Digital Sky Survey’s MaNGA project (MaNGA: Mapping Nearby Galaxies at Apache Point Observatory) and the Very Large Telescope’s FLAMES: Fiber Large Array Multi Element Spectrograph. We isolate sources of fiber systematics and estimate the observed amplitude of persistent residuals as well as stochastic noise contributions resulting from changing fiber stresses. Comparing these levels against their impact on various sky subtraction schemes demonstrates that 0.1% precision sky subtraction with fiber instruments is possible. As a demonstration, we show that the MaNGA instrument can deliver 0.2% residuals on bright near-IR sky lines with nonlocal sky subtraction, if pseudo-slit limitations are addressed by allocating 50% of its fibers to sky. We further highlight recently published deep exposures that achieved a 1σ background level of 27.6 AB per square arc second, equivalent to a precision of 0.2% of the sky background continuum.

Spatially resolved spectroscopy from SDSS-IV MaNGA survey has revealed a class of quiescent, relatively common early-type galaxies, termed "red geysers", that possibly host large scale active galactic nuclei driven winds. Given their potential importance in maintaining low level of star formation at late times, additional evidence confirming that winds are responsible for the red geyser phenomenon is critical. In this work, we present follow-up observations with the Echellette Spectrograph and Imager (ESI) at the Keck telescope of two red geysers (z$, Comment: 20 pages, 23 figures, accepted for publication in the Astrophysical journal

Accurate active galactic nucleus (AGN) identifications and spatially resolved host galaxy properties are a powerful combination for studies of the role of AGNs and AGN feedback in the coevolution of galaxies and their central supermassive black holes. Here, we present robust identifications of 406 AGNs in the first 6261 galaxies observed by the integral field spectroscopy survey Mapping Nearby Galaxies at Apache Point Observatory (MaNGA). Instead of using optical line flux ratios, which can be difficult to interpret in light of the effects of shocks and metallicity, we identify the AGNs via mid-infrared WISE colors, Swift/BAT ultra hard X-ray detections, NVSS and FIRST radio observations, and broad emission lines in SDSS spectra. We subdivide the AGNs into radio-quiet and radio-mode AGNs, and examine the correlations of the AGN classes with host galaxy star formation rates and stellar populations. When compared to the radio-quiet AGN host galaxies, we find that the radio-mode AGN host galaxies reside preferentially in elliptical galaxies, lie further beneath the star-forming main sequence (with lower star formation rates at fixed galaxy mass), have older stellar populations, and have more negative stellar age gradients with galactocentric distance (indicating inside-out quenching of star formation). These results establish a connection between radio-mode AGNs and the suppression of star formation., 13 pages, 6 figures, accepted for publication in ApJ. The AGN catalog fits file is available at https://casa.colorado.edu/~juco5173/Comerford2020/

The effects of COVID-19 on the global economy have been and will be, catastrophic. However, the full global impact, in both economic and health terms, remains unknown. The consequences in Low- and Middle-Income countries, such as Nepal, where national economies rely on a small number of services and industries, are deeply worrying.

In the present study, ZnO–Fe3O4 nanoparticles were synthesized using the leaves of Camellia sinensis and immobilized in crosslinked alginate–chitosan polymer beads and tested for their photocatalytic applications. The prepared nanocomposite was used for the simultaneous adsorption and photocatalytic degradation of acid violet 7 (AV7) dye. The optimization of reaction conditions ensured higher dye removal efficacy up to 94.21 ± 1.02% using the nanocomposite under UV-C irradiation of 365 nm. The kinetics of the adsorption study fitted well with the pseudo-first-order reaction. The Langmuir model fitted better to the adsorption isotherms compared to the Freundlich and Temkin models. The mechanism of degradation was studied by analyzing the treated AV7 solution. The removal efficiency in tap water, groundwater, and lake water was 83.23 ± 0.4%, 69.13 ± 1.6%, and 67.89 ± 0.3%, respectively. The residual toxicity of the degraded AV7 solution was tested on model organisms like freshwater algae, Scenedesmus sp., and plant model, Allium cepa, demonstrating the lower toxicity of the degraded AV7 product. Finally, a cost–benefit analysis of the experiments was also carried out.

We present 150 MHz, 1.4 GHz, and 3 GHz radio imaging (LoTSS, FIRST and VLASS) and spatially resolved ionized gas characteristics (SDSS IV-MaNGA) for 140 local ($z, 23 pages, 14 figures. Accepted for publication in The Astrophysical Journal

We present a sample of 48 nearby galaxies with central, biconical outflows identified by the Mapping Nearby Galaxies at APO (MaNGA) survey. All considered galaxies have star formation driven bi-conical central outflows (SFB), with no signs of AGN. We find that the SFB outflows require high central concentration of the star formation rate. This increases the gas velocity dispersion over the equilibrium limit and helps maintain the gas outflows. The central starbursts increase the metallicity, extinction, and the alpha/Fe ratio in the gas. Significant amount of young stellar population at the centers suggests that the SFBs are associated with the formation of young bulges in galaxies. More than 70% of SFB galaxies are group members or have companions with no prominent interaction, or show asymmetry of external isophotes. In 15% SFB cases stars and gas rotate in the opposite directions, which points at the gas infall from satellites as the primary reason for triggering the SFB phenomena., 10 pages, 10 figures. Accepted by ApJ

Diverse antibiotic drugs have been used for the treatment of bacterial infections; however, their overuse, improper handling, and limitations in treatment facilities can result in their accumulation and biotransformation in the water systems. These bio-accumulated antibiotics can lead to more detrimental effects due to the emergence of multi-resistant bacterial genes at the micro-level, which in turn enhance the chances of bacterial survival. The current review discusses the prevalence of this contaminant in India and different countries around the globe. Since prevention of antibiotic release is the most effective strategy for controlling water pollution, the importance of several governing bodies and their guidelines for antibiotic use and release have been discussed. As a solution to the increasing threat of antibiotics in treated wastewater and natural waters, various treatment strategies have been explored, of which photocatalytic degradation is one of the significant treatment options. In particular, the review focuses on the multiple approaches of photocatalytic degradation in a stand-alone system and in combination with other techniques and nanomaterials. Different photo-active materials, reactor systems, oxide molecular release, kinetic mechanisms, influence of different parameters and characterizations involved have been discussed in detail in order to understand the optimum conditions for photocatalytic degradation of antibiotics.

We compare the rise and decay timescales of $\sim$200 long-term ($\sim$weeks-months) GeV and R-band outbursts and $\sim$25 short-term ($\sim$hr-day) GeV flares in a sample of 10 blazars using light curves from the Fermi-LAT and the Yale/SMARTS monitoring project. We find that most of the long-term outbursts are symmetric, indicating that the observed variability is dominated by the crossing timescale of a disturbance, e.g., a shock. A larger fraction of short-term flares are asymmetric with an approximately equal fraction of longer and shorter decay than rise timescale. We employ the MUlti-ZOne Radiation Feedback (MUZORF) model to interpret the above results. We find that the outbursts with slow rise times indicate a gradual acceleration of the particles to GeV energy. A change in the bulk Lorentz factor of the plasma or the width of the shocked region can lead to an increase of the cooling time causing a faster rise than decay time. Parameters such as the luminosity or the distance of the broad line region (BLR) affects the cooling time strongly if a single emission mechanism, e.g., external Compton scattering of BLR photons is considered but may not if other mechanisms, e.g., synchrotron self-compton and external Compton scattering of the torus photon are included. This work carries out a systematic study of the symmetry of flares, which can be used to estimate relevant geometric and physical parameters of blazar jets in the context of the MUZORF model., 22 pages, 14 figures. Accepted for publication in MNRAS

The Wide Field Optical Spectrometer (WFOS) is a seeing limited, multi-object spectrograph and first light instrument for the Thirty Meter Telescope (TMT) scheduled for first observations in 2027. The spectrograph will deliver a minimum resolution of R~5,000 over a simultaneous wavelength range of 310 nm to 1,000 nm with a multiplexing goal of between 20 and 700 targets. The WFOS team consisting of partners in China, India, Japan, and the United States has completed a trade study of two competing concepts intended to meet the design requirements derived from the WFOS detailed science case. The first of these design concepts is a traditional slit mask instrument capable of delivering R~1,000 for up to 100 simultaneous targets using 1 x 7 arc second slits, and a novel focal plane slicing method for R~5,000 on up to 20 simultaneous targets can be achieved by reformatting the 1 arc-second wide slits into three 0.3 arc-second slits projected next to each other in the spatial direction. The second concept under consideration is a highly multiplexed fiber based system utilizing a robotic fiber positioning system at the focal plane containing 700 individual collectors, and a cluster of up to 12 replicated spectrographs with a minimum resolution of R~5,000 over the full pass band. Each collecting element will contain a bundle of 19 fibers coupled to micro-lens arrays that allow for contiguous coverage of targets and adaptation of the f/15 telescope beam to f/3.2 for feeding the fiber system. This report describes the baseline WFOS design, provides an overview of the two trade study concepts, and the process used to down-select between the two options. Also included is a risk assessment regarding the known technical challenges in the selected design concept.

A new class of quiescent galaxies harboring possible AGN-driven winds has been discovered using spatially resolved optical spectroscopy from the ongoing SDSS-IV MaNGA survey. These galaxies, termed "red geysers", constitute $5-10\%$ of the local quiescent population and are characterized by narrow bisymmetric patterns in ionized gas emission features. Cheung et al. argued that these galaxies host large-scale AGN-driven winds that may play a role in suppressing star formation at late times. In this work, we test the hypothesis that AGN activity is ultimately responsible for the red geyser phenomenon. We compare the nuclear radio activity of the red geysers to a matched control sample with similar stellar mass, redshift, rest frame $NUV-r$ color, axis ratio and presence of ionized gas. We have used the 1.4 GHz radio continuum data from VLA FIRST survey to stack the radio flux from the red geyser and control samples. In addition to a 3 times higher FIRST detection rate, we find that red geysers have a 5$\sigma$ higher level of average radio flux than control galaxies. After restricting to rest-frame $NUV-r$ color $>$ 5 and checking mid-IR WISE photometry, we rule out star formation contamination and conclude that red geysers are associated with more active AGN. Red geysers and a possibly-related class with disturbed H$\alpha$ emission account for 40\% of all radio-detected red galaxies with $\rm log~(M_\star/M_\odot) < 11$. Our results support a picture in which episodic AGN activity drives large-scale-relatively weak ionized winds that may provide a feedback mechanism for many early-type galaxies., Comment: 15 pages, 10 figures, accepted for publication in the Astrophysical journal