80 results on '"Nana, Sato"'
Search Results
2. Active Sugar Accumulation and Water Status of Watermelon Fruit Grown under Different Nutrient Concentrations in Hydroponic Culture
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Sentaro Tomiyama, Hiroshi Yakushiji, Masako Osawa, Kenta Yanagida, Nana Sato, Yusuke Matsumoto, and Takashi Ikeda
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13c ,liquid fertilizer ,osmotic pressure ,sugar analysis ,Plant culture ,SB1-1110 - Abstract
We investigated sugar (solute) accumulation in watermelon [Citrullus lanatus (Thunb.) Matsum. et Nakai] fruits at the immature stage. Watermelon plants were grown hydroponically in a nutrient solution with an electric conductivity (EC) of 1.2 S⋅m−1 (EC 1.2 regime); then, fruits were harvested 21 days after anthesis. The flesh of each fruit was divided into seven different parts to measure the sugar concentration and water status. The results indicated that the sugar concentration was higher in the center of the fruit flesh than in the other parts, such as around the pericarp. Moreover, the lowest osmotic potential was observed in the center of the fruit flesh, indicating solute accumulation. Concurrently, when the transport of photosynthates in the fruit was investigated using the 13CO2 isotope, the active solute accumulation in the center of the fruit flesh was observed, supporting the observed sugar accumulation in this part. Consequently, this active solute accumulation and distribution occurred in the center of the watermelon fruit, as demonstrated by the data of osmotic pressure and sugar concentration and supported by the observed active photosynthate accumulation. Additionally, we investigated these measurements by increasing the nutrient solution concentration 14 days after anthesis. As a result, fruit growth was slightly inhibited using the EC 3.0 regime, and 13C translocation was also inhibited in the fruit, especially in its center. Even though the sugar concentration and osmotic pressure of the fruit flesh were not clearly affected by high nutrient solution concentrations, the cell turgor of the central flesh of the fruit grown using the EC 2.0 and 3.0 regimes was lower than that of the fruit grown using the EC 1.2 regime. Treatments with higher nutrient concentrations might have negative effects on immature watermelon fruits. more...
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- 2023
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3. Future-proofing geotechnics workflows: accelerating problem-solving with large language models.
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Stephen Wu 0001, Yu Otake, Daijiro Mizutani, Chang Liu, Kotaro Asano, Nana Sato, Hidetoshi Baba, Yusuke Fukunaga, Yosuke Higo, Akiyoshi Kamura, Shinnosuke Kodama, Masataka Metoki, Tomoka Nakamura, Yuto Nakazato, Taiga Saito, Akihiro Shioi, Masahiro Takenobu, Keigo Tsukioka, and Ryo Yoshikawa more...
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- 2023
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4. Lymphatic Absorption of Microbial Plasmalogens in Rats
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Nana Sato, Aki Kanehama, Akiko Kashiwagi, Miwa Yamada, and Megumi Nishimukai
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ethanolamine plasmalogen ,Selenomonas ruminantium ,lymphatic absorption ,molecular species ,microbial plasmalogen ,Biology (General) ,QH301-705.5 - Abstract
Plasmalogens, functional glycerophospholipids with biological roles in the human body, are associated with various diseases. Although a variety of saturated and/or unsaturated fatty acids in plasmalogens are presumed to have different functions in the human body, there are limited reports validating such functions of plasmalogens. In this study, we focused on the bacterial plasmalogen derived from Selenomonas ruminantium subsp. lactilytica (NBRC No. 103574) with different main species of hydrocarbon chains at the sn-1 position and shorter fatty acids at the sn-2 position than animal plasmalogens. Optimum culture conditions of S. ruminantium for high-yield production of plasmalogens, such as pH and the concentration of caproic acid, were investigated under anaerobic conditions using a 2-L scale jar fermenter. The obtained plasmalogen mainly consisted of the ethanolamine plasmalogen (PlsEtn). The molar ratios of PlsEtn species obtained from S. ruminantium, at sn-1/sn-2 positions, were p16:1/14:0 (68.4%), p16:1/16:1 (29.2%), p16:1/16:0 (0.7%), p16:1/15:0 (0.3%), and p17:1/14:0 (0.3%). Subsequently, duodenal infusion of the emulsion carrying the lipid extracted from S. ruminantium was carried out in lymph duct-cannulated rats. In the lymphatic plasmalogen of rats, the level of PlsEtns with molar ratios p16:1/14:0 and p16:1/16:1, the main species of plasmalogens from S. ruminantium, increased gradually until 3–4 h after lipid injection and then gradually decreased. In addition, the level of PlsEtns with p16:1/20:4 and p16:1/22:6 rapidly increased, peaking at 1–1.5 h and 1.5–2 h after lipid injection, respectively. The increase in the number of PlsEtns with p16:1/20:4 and p16:1/22:6 suggested that 20:4 and 22:6, the main fatty acids at the sn-2 position in the rat lymphatic plasmalogen, were preferentially re-esterified at the sn-2 position, regardless of the types of hydrocarbon chains at the sn-1 position. Thus, we showed that bacterial PlsEtns with “unnatural” structures against rats could be absorbed into the lymph. Our findings provide insights into the association between the chemical structure of plasmalogens and their biological functions in humans. more...
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- 2022
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5. Effect of dexmedetomidine on cardiorespiratory regulation in spontaneously breathing adult rats
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Yoichiro Kitajima, Nana Sato Hashizume, Chikako Saiki, Ryoji Ide, and Toshio Imai
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Medicine ,Science - Abstract
Purpose We examined the cardiorespiratory effect of dexmedetomidine, an α2- adrenoceptor/imidazoline 1 (I1) receptor agonist, in spontaneously breathing adult rats. Methods Male rats (226−301 g, n = 49) under isoflurane anesthesia had their tail vein cannulated for drug administration and their tail artery cannulated for analysis of mean arterial pressure (MAP), pulse rate (PR), and arterial blood gases (PaO2, PaCO2, pH). After recovery, one set of rats received normal saline for control recording and was then divided into three experimental groups, two receiving dexmedetomidine (5 or 50 μg·kg−1) and one receiving normal saline (n = 7 per group). Another set of rats was divided into four groups receiving dexmedetomidine (50 μg·kg−1) followed 5 min later by 0.5 or 1 mg∙kg−1 atipamezole (selective α2-adrenoceptor antagonist) or efaroxan (α2-adrenoceptor/I1 receptor antagonist) (n = 6 or 8 per group). Recordings were performed 15 min after normal saline or dexmedetomidine administration. Results Compared with normal saline, dexmedetomidine (5 and 50 μg·kg−1) decreased respiratory frequency (fR, p = 0.04 and < 0.01, respectively), PR (both p < 0.01), and PaO2 (p = 0.04 and < 0.01), and increased tidal volume (both p = 0.049). Dexmedetomidine at 5 μg·kg−1 did not significantly change minute ventilation (V′E) (p = 0.87) or MAP (p = 0.24), whereas dexmedetomidine at 50 μg·kg−1 significantly decreased V′E (p = 0.03) and increased MAP (p < 0.01). Only dexmedetomidine at 50 μg·kg−1 increased PaCO2 (p < 0.01). Dexmedetomidine (5 and 50 μg·kg−1) significantly increased blood glucose (p < 0.01), and dexmedetomidine at 50 μg·kg−1 increased hemoglobin (p = 0.04). Supplemental atipamezole or efaroxan administration similarly prevented the 50 μg·kg−1 dexmedetomidine-related cardiorespiratory changes. Principal conclusion These results suggest that dexmedetomidine-related hypoventilation and hypertension are observed simultaneously and occur predominantly through activation of α2-adrenoceptors, but not I1 receptors, in spontaneously breathing adult rats. more...
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- 2022
6. Effectiveness of an Internet-Based Machine-Guided Stress Management Program Based on Cognitive Behavioral Therapy for Improving Depression Among Workers: Protocol for a Randomized Controlled Trial
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Norito Kawakami, Kotaro Imamura, Kazuhiro Watanabe, Yuki Sekiya, Natsu Sasaki, and Nana Sato
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Medicine ,Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
BackgroundThe effect of an unguided internet-based cognitive behavioral therapy (iCBT) stress management program on depression may be enhanced by applying artificial intelligence (AI) technologies to guide participants adopting the program. ObjectiveThe aim of this study is to describe a research protocol to investigate the effect of a newly developed iCBT stress management program adopting AI technologies on improving depression among healthy workers during the COVID-19 pandemic. MethodsThis study is a two-arm, parallel, randomized controlled trial. Participants (N=1400) will be recruited, and those who meet the inclusion criteria will be randomly allocated to the intervention or control (treatment as usual) group. A 6-week, six-module, internet-based stress management program, SMART-CBT, has been developed that includes machine-guided exercises to help participants acquire CBT skills, and it applies machine learning and deep learning technologies. The intervention group will participate in the program for 10 weeks. The primary outcome, depression, will be measured using the Beck Depression Inventory II at baseline and 3- and 6-month follow-ups. A mixed model repeated measures analysis will be used to test the intervention effect (group × time interactions) in the total sample (universal prevention) on an intention-to-treat basis. ResultsThe study was at the stage of recruitment of participants at the time of submission. The data analysis related to the primary outcome will start in January 2022, and the results might be published in 2022 or 2023. ConclusionsThis is the first study to investigate the effectiveness of a fully automated machine-guided iCBT program for improving subthreshold depression among workers using a randomized controlled trial design. The study will explore the potential of a machine-guided stress management program that can be disseminated online to a large number of workers with minimal cost in the post–COVID-19 era. Trial RegistrationUMIN Clinical Trials Registry(UMIN-CTR) UMIN000043897; https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000050125 International Registered Report Identifier (IRRID)PRR1-10.2196/30305 more...
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- 2021
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7. Analysis of Purine Metabolism to Elucidate the Pathogenesis of Acute Kidney Injury in Renal Hypouricemia
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Daisuke Miyamoto, Nana Sato, Koji Nagata, Yukinao Sakai, Hitoshi Sugihara, Yuki Ohashi, Blanka Stiburkova, Ivan Sebesta, Kimiyoshi Ichida, and Ken Okamoto
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hypouricemia ,xanthinuria ,acute kidney injury ,Biology (General) ,QH301-705.5 - Abstract
Renal hypouricemia is a disease caused by the dysfunction of renal urate transporters. This disease is known to cause exercise-induced acute kidney injury, but its mechanism has not yet been established. To analyze the mechanism by which hypouricemia causes renal failure, we conducted a semi-ischemic forearm exercise stress test to mimic exercise conditions in five healthy subjects, six patients with renal hypouricemia, and one patient with xanthinuria and analyzed the changes in purine metabolites. The results showed that the subjects with renal hypouricemia had significantly lower blood hypoxanthine levels and increased urinary hypoxanthine excretion after exercise than healthy subjects. Oxidative stress markers did not differ between healthy subjects and hypouricemic subjects before and after exercise, and no effect of uric acid as a radical scavenger was observed. As hypoxanthine is a precursor for adenosine triphosphate (ATP) production via the salvage pathway, loss of hypoxanthine after exercise in patients with renal hypouricemia may cause ATP loss in the renal tubules and consequent tissue damage. more...
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- 2022
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8. Immunobiotic Lactobacillus jensenii TL2937 Alleviates Dextran Sodium Sulfate-Induced Colitis by Differentially Modulating the Transcriptomic Response of Intestinal Epithelial Cells
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Nana Sato, Valeria Garcia-Castillo, Mao Yuzawa, Md. Aminul Islam, Leonardo Albarracin, Mikado Tomokiyo, Wakako Ikeda-Ohtsubo, Apolinaria Garcia-Cancino, Hideki Takahashi, Julio Villena, and Haruki Kitazawa more...
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immunobiotics ,intestinal inflammation ,Lactobacillus jensenii TL2937 ,PIE cells ,immunotranscriptomic response ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Immunobiotics have emerged as a promising intervention to alleviate intestinal damage in inflammatory bowel disease (IBD). However, the beneficial properties of immunobiotics are strain dependent and, therefore, each strain has to be evaluated in order to demonstrate its potential application in IBD. Our previous in vitro and in vivo studies demonstrated that Lactobacillus jensenii TL2937 attenuates gut acute inflammatory response triggered by Toll-like receptor 4 activation. However, its effect on colitis has not been evaluated before. In this work, we studied whether the TL2937 strain was able to protect against the development of colitis in a dextran sodium sulfate (DSS)-induced mouse model and we delved into the mechanisms of action by evaluating the effect of the immunobiotic bacteria on the transcriptomic response of DSS-challenged intestinal epithelial cells. L. jensenii TL2937 was administered to adult BALB/c mice before the induction of colitis by the administration of DSS. Colitis and the associated inflammatory response were evaluated for 14 days. Mice fed with L. jensenii TL2937 had lower disease activity index and alterations of colon length when compared to control mice. Reduced myeloperoxidase activity, lower production of pro-inflammatory (TNF-α, IL-1, CXCL1, MCP-1, IL-15, and IL-17), and higher levels of immunoregulatory (IL-10 and IL-27) cytokines were found in the colon of TL2937-treated mice. In addition, the treatment of porcine intestinal epithelial (PIE) cells with L. jensenii TL2937 before the challenge with DSS differentially regulated the activation of the JNK pathway, leading to an increase in epithelial cell integrity and to a differential immunotranscriptomic response. TL2937-treated PIE cells had a significant reduction in the expression of inflammatory cytokines (TNF-α, IL-1α, IL-1β, IL-6, IL-15), chemokines (CCL2, CCL4, CCL8, CXCL4, CXCL5, CXCL9, CXCL10), adhesion molecules (SELE, SELL, EPCAM), and other immune factors (NCF1, NCF2, NOS2, SAA2) when compared to control cells after the challenge with DSS. The findings of this work indicate that (a) L. jensenii TL2937 is able to alleviate DSS-induced colitis suggesting a potential novel application for this immunobiotic strain, (b) the modulation of the transcriptomic response of intestinal epithelial cells would play a key role in the beneficial effects of the TL2937 strain on colitis, and (c) the in vitro PIE cell immunoassay system could be of value for the screening and selection of new immunobiotic strains for their application in IBD. more...
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- 2020
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9. Possible Use of Non-purine Selective Xanthine Oxidoreductase Inhibitors for Prevention of Exercise-induced Acute Kidney Injury Associated with Renal Hypouricemia: A Case Report
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Chiharu Aizawa, Masahiro Okabe, Daisuke Takahashi, Makoto Sagasaki, Mao Watanabe, Toshinari Fujimoto, Yuuki Yoshioka, Ai Katsuma, Ai Kimura, Daisuke Miyamoto, Nana Sato, Ken Okamoto, Kimiyoshi Ichida, Yoichi Miyazaki, and Takashi Yokoo more...
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Internal Medicine ,General Medicine - Published
- 2023
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10. Associations Between Health Literacy and Changes in Exercise Behavior During the Coronavirus Disease 2019 State of Emergency Among Middle-Aged Adults: A Cross-Sectional Online Survey
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Yoshiaki Taniguchi, Shoma Akaida, Ryuhei Shiiba, Mana Tateishi, Hyuma Makizako, Ayumi Wada, Daijo Shiratsuchi, Saki Shono, Kazutoshi Tomioka, Yuki Nakai, Yuto Kiuchi, and Nana Sato
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Adult ,2019-20 coronavirus outbreak ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Health Behavior ,Public Health, Environmental and Occupational Health ,MEDLINE ,COVID-19 ,Health literacy ,Middle Aged ,Health Literacy ,Cross-Sectional Studies ,Surveys and Questionnaires ,Family medicine ,Humans ,Medicine ,Exercise behavior ,business ,Exercise - Published
- 2021
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11. Are satisfaction and performance of meaningful activities associated with frailty in older adults?
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Shoma Akaida, Takayuki Tabira, Yuki Nakai, Michio Maruta, Yoshiaki Taniguchi, Kazutoshi Tomioka, Nana Sato, Ayumi Wada, and Hyuma Makizako
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Aging ,Health (social science) ,Geriatrics and Gerontology ,Gerontology - Published
- 2022
12. Translation and Translation Studies in the Japanese Context
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Nana Sato-Rossberg, Nana Sato-Rossberg, Judy Wakabayashi
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- 2012
13. Associations Between Personal Values and Work Engagement
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Daisuke Nishi, Nana Sato, Norito Kawakami, and Kazuhiro Watanabe
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Value (ethics) ,Cross-sectional study ,Work engagement ,Public Health, Environmental and Occupational Health ,Sample (statistics) ,Work Engagement ,Cross-Sectional Studies ,Negatively associated ,Bayesian multivariate linear regression ,Multivariate Analysis ,Income ,Linear Models ,Openness to experience ,Humans ,Psychology ,Social psychology - Abstract
Objective This study aimed to investigate associations between personal values and work engagement among workers. Methods This cross-sectional study used data from the Japanese Study on Stratification, Health, Income, and Neighborhood (J-SHINE) in 2010 and 2017. Personal values were measured by 11 value priorities and by commitment to these values. Multivariate linear regression analyses were conducted to determine the associations between personal values and work engagement. Results A total of 1,946 workers were analyzed. Four personal values (e.g., "Improving society") and commitment to values were significantly positively associated with work engagement, while "Graduating from a famous school" was significantly negatively associated. Conclusions Some personal values relate to openness to change, self-transcendence, and self-enhancement, and commitment to values showed associations with work engagement. It could be beneficial to consider personal values to enhance work engagement. more...
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- 2021
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14. Paraimmunobiotic Bifidobacteria Modulate the Expression Patterns of Peptidoglycan Recognition Proteins in Porcine Intestinal Epitheliocytes and Antigen Presenting Cells
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Hikaru Iida, Masanori Tohno, Md. Aminul Islam, Nana Sato, Hisakazu Kobayashi, Leonardo Albarracin, AKM Humayun Kober, Wakako Ikeda-Ohtsubo, Yoshihito Suda, Hisashi Aso, Tomonori Nochi, Ayako Miyazaki, Hirohide Uenishi, Noriyuki Iwabuchi, Jin-zhong Xiao, Julio Villena, and Haruki Kitazawa more...
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paraimmunobiotics ,peptidoglycan recognition protein ,bifidobacteria ,innate immunity ,porcine intestinal epitheliocytes ,porcine antigen-presenting cells ,Cytology ,QH573-671 - Abstract
Peptidoglycan recognition proteins (PGLYRPs) are a family of pattern recognition receptors (PRRs) that are able to induce innate immune responses through their binding to peptidoglycan (PGN), lipopolysaccharide, or lipoteichoic acid, or by interacting with other PRR-ligands. Recently, progress has been made in understanding the immunobiology of PGLYRPs in human and mice, however, their functions in livestock animals have been less explored. In this study, we characterized the expression patterns of PGLYRPs in porcine intestinal epithelial (PIE) cells and antigen-presenting cells (APCs) and their modulation by the interactions of host cells with PRR-ligands and non-viable immunomodulatory probiotics referred to as paraimmunobiotics. We demonstrated that PGLYRP-1, -2, -3, and -4 are expressed in PIE cells and APCs from Peyer’s patches, being PGLYPR-3 and -4 levels higher than PGLYRP-1 and -2. We also showed that PGLYRPs expression in APCs and PIE cells can be modulated by different PRR agonists. By using knockdown PIE cells for TLR2, TLR4, NOD1, and NOD2, or the four PGLYRPs, we demonstrated that PGLYRPs expressions would be required for activation and functioning of TLR2, TLR4, NOD1, and NOD2 in porcine epitheliocytes, but PGLYRPs activation would be independent of those PRR expressions. Importantly, we reported for the first time that PGLYRPs expression can be differentially modulated by paraimmunobiotic bifidobacteria in a strain-dependent manner. These results provide evidence for the use of paraimmunobiotic bifidobacteria as an alternative for the improvement of resistance to intestinal infections or as therapeutic tools for the reduction of the severity of inflammatory damage in diseases in which a role of PGLYRPs-microbe interaction has been demonstrated. more...
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- 2019
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15. Evaluation of Porcine Intestinal Epitheliocytes as an In vitro Immunoassay System for the Selection of Probiotic Bifidobacteria to Alleviate Inflammatory Bowel Disease
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Apolinaria García-Cancino, Valeria Garcia-Castillo, Julio Villena, Mao Yuzawa, Islam Aminul, Wakako Ideka-Ohtsubo, Haruki Kitazawa, Noriyuki Iwabuchi, Jin-zhong Xiao, Leonardo Albarracin, Mikado Tomokiyo, and Nana Sato more...
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0301 basic medicine ,Bifidobacterium breve ,ved/biology ,030106 microbiology ,ved/biology.organism_classification_rank.species ,Inflammation ,Biology ,medicine.disease ,Microbiology ,CCL8 ,Inflammatory bowel disease ,In vitro ,law.invention ,03 medical and health sciences ,Probiotic ,030104 developmental biology ,law ,CXCL5 ,Immunology ,medicine ,Molecular Medicine ,CXCL10 ,medicine.symptom ,Molecular Biology - Abstract
The use of in vitro systems that allow efficient selection of probiotic candidates with immunomodulatory properties could significantly minimize the use of experimental animals. In this work, we generated an in vitro immunoassay system based on porcine intestinal epithelial (PIE) cells and dextran sodium sulfate (DSS) administration that could be useful for the selection and characterization of potential probiotic strains to be used in inflammatory bowel disease (IBD) patients. Our strategy was based on two fundamental pillars: on the one hand, the capacity of PIE cells to create a monolayer by attaching to neighboring cells and efficiently mount inflammatory responses and, on the other hand, the use of two probiotic bifidobacteria strains that have been characterized in terms of their immunomodulatory capacities, particularly in mouse IBD models and patients. Our results demonstrated that DSS administration can alter the epithelial barrier created in vitro by PIE cells and induce a potent inflammatory response, characterized by increases in the expression levels of several inflammatory factors including TNF-α, IL-1α, CCL4, CCL8, CCL11, CXCL5, CXCL9, CXCL10, SELL, SELE, EPCAM, VCAM, NCF2, and SAA2. In addition, we demonstrated that Bifidobacterium breve M-16V and B. longum BB536 are able to regulate the C-jun N-terminal kinase (JNK) intracellular signalling pathway, reducing the DSS-induced alterations of the in vitro epithelial barrier and differentially regulating the inflammatory response in a strain-dependent fashion. The good correlation between our in vitro findings in PIE cells and previous studies in animal models and IBD patients shows the potential value of our system to select new probiotic candidates in an efficient way. more...
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- 2020
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16. Modified forearm ischemic test in hypouricemic patients
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Shuichi Tsuruoka, Koji Nagata, Ken Okamoto, Daisuke Miyamoto, Blanka Stiburkova, Ivan Sebesta, Sarka Blahova, Kimiyoshi Ichida, and Nana Sato
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Adult ,Male ,medicine.medical_specialty ,Renal Tubular Transport, Inborn Errors ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Pathogenesis ,Forearm ,Ischemia ,Internal medicine ,Genetics ,medicine ,Humans ,RENAL HYPOURICEMIA ,Lactic Acid ,Hypouricemia ,Pathological ,Hypoxanthine ,010405 organic chemistry ,Chemistry ,Hereditary xanthinuria ,Acute kidney injury ,General Medicine ,Middle Aged ,medicine.disease ,Uric Acid ,0104 chemical sciences ,medicine.anatomical_structure ,Exercise Test ,Cardiology ,Molecular Medicine ,Female ,Urinary Calculi - Abstract
Renal hypouricemia sometimes leads to exercise-induced acute kidney injury (EIAKI) of unknown pathogenesis. In order to elucidate the various pathological conditions associated with hypouricemia, we analyzed the effects of low uric acid level on energy metabolism. We have modified semi-ischemic forearm exercise test and performed this test in one Japanese healthy volunteer, three patients with hereditary renal hypouricemia and one patient with hereditary xanthinuria of Czech origin. Forearm exercise was performed by squeezing a hand dynamometer with the sphygmomanometer cuff pressure kept at the mean arterial pressure. Venous blood was drawn five times (before exercise, 3, 10, 30, 45 minutes after the start of exercise) in each tests. The mean plasma lactate concentration increased from a baseline of 1.3 (range 0.7-1.8 mmol/L) to 4.0 (range 2.0-5.5 mmol/L) at 3 minutes after the start of exercise. The plasma hypoxanthine concentrations were quite low before exercise (0-2.9 μmol/L), but increased markedly to a range of 13.6-28.8 μmol/L after 10 minute forearm ischemia. Our protocol allowed us to conclude that the load was sufficient for observing metabolic changes in temporally hypoxia and in following recovery phase. The test was well tolerated and safe, we did not observe any adverse reactions including EIAKI. more...
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- 2020
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17. Efficient Anticancer Drug Delivery for Pancreatic Cancer Treatment Utilizing Supramolecular Polyethylene-Glycosylated Bromelain
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Tetsuya Kogo, Nana Sato, Daisuke Iohara, Hidetoshi Arima, Risako Onodera, Hideaki Nakamura, Taishi Higashi, Keiichi Motoyama, Shogo Misumi, and Tatsunori Hirotsu
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chemistry.chemical_classification ,Cyclodextrin ,Bromelain (pharmacology) ,Adamantane ,Biochemistry (medical) ,Biomedical Engineering ,Supramolecular chemistry ,Cancer ,General Chemistry ,medicine.disease ,Anticancer drug ,Biomaterials ,chemistry.chemical_compound ,chemistry ,Pancreatic cancer ,Extracellular ,medicine ,Cancer research - Abstract
Pancreatic cancer is one of the most difficult cancers to treat largely because of the inability of anticancer drugs to penetrate into the cancer tissue as the result of the dense extracellular matrix (ECM). On the other hand, bromelain is known to degrade the ECM in cancerous tissue. However, the half-life of bromelain in blood is short, leading to its low accumulation in tissues. Recently, we developed a reversible poly(ethylene glycol) (PEG) modification technology that is able to improve blood retention of proteins without loss of activity and termed it "Self-assembly PEGylation Retaining Activity (SPRA)" technology. Here, we prepared reversible PEGylated bromelain using SPRA technology (SPRA-bromelain) possessing high activity, long blood retention, and high tumor accumulation and evaluated its potential as a drug delivery system for pancreatic cancer. SPRA-bromelain was prepared by mixing adamantane-modified bromelain and multisubstituted-PEGylated β-cyclodextrins (β-CyDs) containing 2 or 20 kDa PEG chains in water. SPRA-bromelain was formed by a host-guest interaction between adamantane and β-CyD ( more...
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- 2020
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18. Association of self-rated health with type and frequency of social interaction during the declaration of COVID-19 state of emergency among Japanese community-dwelling oldest-old adults
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Shoma Akaida, Yuki Nakai, Daijo Shiratsuchi, Kazutoshi Tomioka, Yoshiaki Taniguchi, Nana Sato, Ayumi Wada, Yuto Kiuchi, Saki Shono, Ryuhei Shiiba, Mana Tateishi, and Hyuma Makizako
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Aged, 80 and over ,Male ,Cross-Sectional Studies ,Japan ,Health Status ,Social Interaction ,COVID-19 ,Humans ,Female ,Independent Living ,Aged - Abstract
To investigate whether the type and frequency of social interaction during the state of emergency due to coronavirus disease were associated with self-rated health (SRH) after the state of emergency.Data from a cross-sectional study were collected for 889 oldest-old adults in Bibai City, Hokkaido, Japan. In total, 612 participants (mean age: 83.0 ± 4.3 years; women: 51.8%) were included in the analysis, taking biological sex into account. The self-reported questionnaire included questions about demographic variables, SRH (July 2020, after the emergency), and the type and frequency of social interaction (March 2020, during the state of emergency).There was no significant association between social interaction and SRH in men (P 0.05). Women who had social interactions (both face-to-face and non-face-to-face) more than once a week during the state of emergency reported higher SRH after the emergency than those who did not (odds ratio 2.17, 95% confidence interval 1.07-4.41).Having both types of interaction more than once a week during the state of emergency was related to higher SRH after the emergency among oldest-old women. It is suggested that having opportunities for both types of interaction at least once a week would potentially be beneficial for high SRH in women, even in situations where the declaration of a state of emergency restricts face-to-face interaction. Geriatr Gerontol Int 2022; 22: 405-411. more...
- Published
- 2022
19. Are Satisfaction and Performance of Meaningful Activities Associated with Comprehensive Frailty in Older Adults?
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Shoma Akaida, Takayuki Tabira, Yuki Nakai, Michio Maruta, Yoshiaki Taniguchi, Kazutoshi Tomioka, Nana Sato, Ayumi Wada, and Hyuma Makizako
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- 2022
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20. Hypoxanthine Reduces Radiation Damage in Vascular Endothelial Cells and Mouse Skin by Enhancing ATP Production via the Salvage Pathway
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Megumi Fujiwara, Nana Sato, and Ken Okamoto
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Hypoxanthine ,Mice ,Radiation ,Adenosine Triphosphate ,Cell Survival ,Biophysics ,Animals ,Endothelial Cells ,Radiology, Nuclear Medicine and imaging ,Dermatitis - Abstract
An effective method that can protect radiation-damaged tissues from apoptosis and promote tissue repair has not been reported to date. Hypoxanthine (Hx) is an intermediate metabolite in the purine degradation system that serves as a substrate for ATP synthesis via the salvage pathway. In this study, we focused on the transient decrease in intracellular ATP concentration after radiation exposure and examined the protective effect of Hx against radiation-induced tissue damage. Human umbilical vein endothelial cells were X irradiated, and the cell viability and incidence of apoptosis and DNA double-strand breaks (DSBs) were evaluated at different Hx concentrations. We found that in the presence of 2-100 µM Hx, the percentages of DSBs and apoptotic cells after 2, 6 and 10 Gy dose of radiation significantly decreased, whereas cell viability increased in a concentration-dependent manner. Moreover, the addition of Hx increased the levels of AMP, ADP, and ATP in the cells at 2 h postirradiation, suggesting that Hx was used for adenine nucleotide synthesis through the salvage pathway. Administration of a xanthine oxidoreductase inhibitor to a mouse model of radiation dermatitis resulted in increased blood Hx levels that inhibited severe dermatitis and accelerated recovery. In conclusion, the findings provide evidence that increasing the levels of Hx to replenish ATP could be an effective strategy to reduce radiation-induced tissue damage and elucidating the detailed mechanisms underlying the protective effects of Hx could help develop new protective strategies against radiation. more...
- Published
- 2021
21. Effect of dexmedetomidine on cardiorespiratory regulation in spontaneously breathing adult rats
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Kitajima, Yoichiro, primary, Hashizume, Nana Sato, additional, Saiki, Chikako, additional, Ide, Ryoji, additional, and Imai, Toshio, additional
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- 2022
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22. Association between cognitive frailty and higher-level competence among community-dwelling older adults
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Ryoji Kiyama, Toshihiro Takenaka, Ayumi Wada, Takuro Kubozono, Yuto Kiuchi, Yuki Nakai, Nana Sato, Mitsuru Ohishi, Hyuma Makizako, Yoshiaki Taniguchi, and Kazutoshi Tomioka
- Subjects
Gerontology ,Male ,Aging ,Health (social science) ,Frail Elderly ,Logistic regression ,Competence (law) ,Grip strength ,Medicine ,Humans ,Cognitive Dysfunction ,Mental Competency ,Association (psychology) ,Geriatric Assessment ,Aged ,Frailty ,business.industry ,Odds ratio ,Social engagement ,Confidence interval ,Preferred walking speed ,Cross-Sectional Studies ,Female ,Independent Living ,Geriatrics and Gerontology ,business - Abstract
Objectives The purpose of this cross-sectional study was to examine the association between cognitive frailty (CF) and higher-level competence among community-dwelling older adults. Methods Data from 871 older adults (aged ≥ 65 years, mean age 74.3 years, 61.5% women) who had participated in a community-based health check survey (Tarumizu Study 2018-2019) were analyzed. CF was defined as comorbid physical frailty and mild cognitive impairment (MCI). We defined physical frailty as either slow walking speed or poor grip strength. MCI was defined as values below the age- and education-adjusted reference threshold in several tests. Participants were categorized into four groups: robust, physical frailty, MCI, and CF. Higher-level competence was assessed using the Japan Science and Technology Agency Index of Competence (JST-IC). The JST-IC consists of 16 items and four subscales (technology usage, information practice, life management and social engagement). The bottom 20–30% score of the JST-IC and each subscale corresponded to poor higher-level competence. Results The prevalence of CF was 14.4%. Multivariate logistic regression analysis showed that, CF was significantly associated with poor higher-level competence (odds ratio 1.92, 95% confidence interval 1.18–3.13) after adjusting for covariates. Using a similar analysis to assess the JST-IC subscales, CF was associated with limitations on technology usage (odds ratio 2.29, 95% confidence interval 1.36–3.85) and low social engagement (odds ratio 1.62, 95% confidence interval 1.00–2.61). Conclusions This study suggests that CF is associated with poor higher-level competence, especially limitations on technology usage and low social engagement. more...
- Published
- 2021
23. Effectiveness of an Internet-Based Machine-Guided Stress Management Program Based on Cognitive Behavioral Therapy for Improving Depression Among Workers: Protocol for a Randomized Controlled Trial
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Yuki Sekiya, Natsu Sasaki, Nana Sato, Kazuhiro Watanabe, Norito Kawakami, and Kotaro Imamura
- Subjects
Protocol (science) ,medicine.medical_specialty ,Stress management ,universal prevention ,medicine.medical_treatment ,Beck Depression Inventory ,Repeated measures design ,deep learning ,General Medicine ,law.invention ,Cognitive behavioral therapy ,Clinical trial ,workplace ,machine learning ,Randomized controlled trial ,law ,Intervention (counseling) ,unguided intervention ,depression ,medicine ,Physical therapy ,Protocol ,Psychology - Abstract
Background The effect of an unguided internet-based cognitive behavioral therapy (iCBT) stress management program on depression may be enhanced by applying artificial intelligence (AI) technologies to guide participants adopting the program. Objective The aim of this study is to describe a research protocol to investigate the effect of a newly developed iCBT stress management program adopting AI technologies on improving depression among healthy workers during the COVID-19 pandemic. Methods This study is a two-arm, parallel, randomized controlled trial. Participants (N=1400) will be recruited, and those who meet the inclusion criteria will be randomly allocated to the intervention or control (treatment as usual) group. A 6-week, six-module, internet-based stress management program, SMART-CBT, has been developed that includes machine-guided exercises to help participants acquire CBT skills, and it applies machine learning and deep learning technologies. The intervention group will participate in the program for 10 weeks. The primary outcome, depression, will be measured using the Beck Depression Inventory II at baseline and 3- and 6-month follow-ups. A mixed model repeated measures analysis will be used to test the intervention effect (group × time interactions) in the total sample (universal prevention) on an intention-to-treat basis. Results The study was at the stage of recruitment of participants at the time of submission. The data analysis related to the primary outcome will start in January 2022, and the results might be published in 2022 or 2023. Conclusions This is the first study to investigate the effectiveness of a fully automated machine-guided iCBT program for improving subthreshold depression among workers using a randomized controlled trial design. The study will explore the potential of a machine-guided stress management program that can be disseminated online to a large number of workers with minimal cost in the post–COVID-19 era. Trial Registration UMIN Clinical Trials Registry(UMIN-CTR) UMIN000043897; https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000050125 International Registered Report Identifier (IRRID) PRR1-10.2196/30305 more...
- Published
- 2021
24. Mediating Effects of Work Eudemonic Well-being for the Association Between Psychosocial Work Environment and Overall Eudemonic Well-being Among Japanese Workers: A Cross-sectional Study
- Author
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Nana Sato, Kazuhiro Watanabe, and Norito Kawakami
- Subjects
Cross-sectional study ,Job control ,Public Health, Environmental and Occupational Health ,Social Support ,Structural equation modeling ,Job Satisfaction ,Cross-Sectional Studies ,Work (electrical) ,Japan ,Surveys and Questionnaires ,Well-being ,Humans ,Association (psychology) ,Psychology ,Path analysis (statistics) ,Workplace ,Psychosocial ,Clinical psychology - Abstract
OBJECTIVE This study aimed to investigate the mediating effects of eudemonic well-being (EWB) at work for the associations between psychosocial work environment and overall EWB among Japanese workers. METHODS We conducted a cross-sectional study using data from a 2018 survey. psychosocial work environment measures included: job demands, job control, and supervisor and coworker support. Path analysis using structural equation modeling and mediation analysis were applied to examine the mediating effects of work EWB. RESULTS A total of 834 workers were analyzed. Work EWB completely mediated the associations of job control (β = 0.288, P more...
- Published
- 2021
25. Effectiveness of an Internet-Based Machine-Guided Stress Management Program Based on Cognitive Behavioral Therapy for Improving Depression Among Workers: Protocol for a Randomized Controlled Trial (Preprint)
- Author
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Nana Sato, Natsu Sasaki, Yuki Sekiya, and Norito Kawakami
- Abstract
BACKGROUND The effect of an unguided internet-based cognitive behavioral therapy (iCBT) stress management program on depression may be enhanced by applying artificial intelligence (AI) technologies to guide participants adopting the program. OBJECTIVE The aim of this study is to describe a research protocol to investigate the effect of a newly developed iCBT stress management program adopting AI technologies on improving depression among healthy workers during the COVID-19 pandemic. METHODS This study is a two-arm, parallel, randomized controlled trial. Participants (N=1400) will be recruited, and those who meet the inclusion criteria will be randomly allocated to the intervention or control (treatment as usual) group. A 6-week, six-module, internet-based stress management program, SMART-CBT, has been developed that includes machine-guided exercises to help participants acquire CBT skills, and it applies machine learning and deep learning technologies. The intervention group will participate in the program for 10 weeks. The primary outcome, depression, will be measured using the Beck Depression Inventory II at baseline and 3- and 6-month follow-ups. A mixed model repeated measures analysis will be used to test the intervention effect (group × time interactions) in the total sample (universal prevention) on an intention-to-treat basis. RESULTS The study was at the stage of recruitment of participants at the time of submission. The data analysis related to the primary outcome will start in January 2022, and the results might be published in 2022 or 2023. CONCLUSIONS This is the first study to investigate the effectiveness of a fully automated machine-guided iCBT program for improving subthreshold depression among workers using a randomized controlled trial design. The study will explore the potential of a machine-guided stress management program that can be disseminated online to a large number of workers with minimal cost in the post–COVID-19 era. CLINICALTRIAL UMIN Clinical Trials Registry(UMIN-CTR) UMIN000043897; https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000050125 INTERNATIONAL REGISTERED REPORT PRR1-10.2196/30305 more...
- Published
- 2021
- Full Text
- View/download PDF
26. Expression of nischarin, an imidazoline 1 receptor candidate protein, in the ventrolateral medulla of newborn rats
- Author
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Yukari Nagakura, Ryoji Ide, Toshio Imai, Chikako Saiki, and Nana Sato Hashizume
- Subjects
Male ,Neurons ,medicine.medical_specialty ,Medulla Oblongata ,General Neuroscience ,Solitary nucleus ,Spinal trigeminal nucleus ,Intracellular Signaling Peptides and Proteins ,Imidazoline receptor ,Rostral ventrolateral medulla ,Biology ,Rats ,medicine.anatomical_structure ,Endocrinology ,Vestibular nuclei ,Internal medicine ,medicine ,Animals ,Female ,Imidazoline Receptors ,Brainstem ,Cuneate nucleus ,Rats, Wistar ,Medulla - Abstract
The activation of imidazoline 1 (I1) receptors is suggested to stimulate the respiratory drive in newborn rats. Here, we immunohistochemically examined whether nischarin, an I1 receptor candidate protein, is expressed in the ventrolateral medulla, where cardiorespiratory centers are located. Newborn rats (age, 3–5 days) were deeply anesthetized with isoflurane; the brainstem was dissected, sectioned sagittally, and labeled with nischarin. Nischarin-associated signals were observed broadly throughout the newborn rat brainstem, including at motor nuclei (motor trigeminal nucleus and facial nucleus), sensory nuclei (lateral superior olive, medial and spinal vestibular nuclei, cuneate nucleus, spinal trigeminal nucleus, and solitary nucleus), and the rostral and caudal ventrolateral medullar regions. In particular, the rostral ventrolateral medulla included a layer of aggregated nischarin expression along the ventral surface, and the layer was in close contact with GFAP-positive processes. In addition, some Phox2b-positive neurons were positive for nischarin in the region. Our results reveal nischarin expression in the newborn rat brainstem and suggest that I1 receptor activation at the level of the ventrolateral medulla contributes to central chemoreception and respiratory control in newborn rats. more...
- Published
- 2021
27. [Collaboration between academic institutes and public health centers under a public health emergency: lessons learned during the coronavirus pandemic]
- Author
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Kaori, Sumino, Nana, Sato, Kenta, Nakashiba, Keiko, Ohisa, Kana, Fujii, Ayumi, Hashimoto, Mayumi, Kataoka, Hideko, Sato, Yumiko, Kobayashi, Rie, Masuda, Junhua, Zhang, Yuiko, Kijima, Keiko, Nakamura, and Hideki, Hashimoto more...
- Subjects
Organizations ,Japan ,COVID-19 ,Humans ,Public Health ,Intersectoral Collaboration ,Pandemics - Published
- 2021
28. List of contributors
- Author
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Kelvin Elphick, Peter Fischer, William Frost, Takayuki Fujita, Shunsuke Fukami, Akio Fukushima, Hiroshi Handa, Mutsuko Hatano, Burkard Hillebrands, Atsufumi Hirohata, Kazuyoshi Horii, Tomoyuki Irino, Yuto Ishiguro, Tomoko Ishihara, Noriaki Ishikawa, Ewa Jędryka, Balachandran Jeyadevan, Masaya Kakuta, Kensuke Kanda, Nico Kerber, Yoshitaka Kitamoto, Mathias Kläui, Hiroshi Kohno, Hitoshi Kubota, Takahide Kubota, Takahiro Kudo, Moriaki Kusakabe, Akihiro Kuwahata, Dong-Kyu Lee, Kyung-Jin Lee, Hiroaki Mamiya, Luca Marnitz, Sachiko Matsuda, Masaki Mizuguchi, Anastasiia Moskaltsova, Keita Murata, Jotaro J. Nakane, Yoshinobu Nakatani, Ulrich Nowak, Takeshi Ogasawara, Toru Ogawa, Takuo Ohkochi, Tatsuya Onishi, Teruo Ono, Mikihiko Oogane, Masaki Oura, Vincent Polewczyk, Rafael Ramos, Günter Reiss, Yoshiaki Saito, Eiji Saitoh, Nana Sato, Jan-Michael Schmalhorst, Takeshi Seki, Koji Sekiguchi, Masaki Sekino, Bethanie J.H. Stadler, Hiroaki Sukegawa, Motohiro Suzuki, Koki Takanashi, Shingo Tamaru, Kunihisa Tashiro, Gen Tatara, Satoshi Tomita, Tetsuya Ueda, Toshiyuki Ueno, Carlos A.F. Vaz, Hiroyuki Wakiwaka, Markus Weißenhofer, Marek Wójcik, Shin Yabukami, Keisuke Yamada, Akinobu Yamaguchi, Hideto Yanagihara, and Mohammad Reza Zamani Kouhpanji more...
- Published
- 2021
- Full Text
- View/download PDF
29. Evaluation of Porcine Intestinal Epitheliocytes as an In vitro Immunoassay System for the Selection of Probiotic Bifidobacteria to Alleviate Inflammatory Bowel Disease
- Author
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Nana, Sato, Mao, Yuzawa, Md Islam, Aminul, Mikado, Tomokiyo, Leonardo, Albarracin, Valeria, Garcia-Castillo, Wakako, Ideka-Ohtsubo, Noriyuki, Iwabuchi, Jin-Zhong, Xiao, Apolinaria, Garcia-Cancino, Julio, Villena, and Haruki, Kitazawa more...
- Subjects
Immunoassay ,Mice ,Swine ,Probiotics ,Animals ,Cytokines ,Humans ,Epithelial Cells ,Bifidobacterium ,Chemokines ,Inflammatory Bowel Diseases - Abstract
The use of in vitro systems that allow efficient selection of probiotic candidates with immunomodulatory properties could significantly minimize the use of experimental animals. In this work, we generated an in vitro immunoassay system based on porcine intestinal epithelial (PIE) cells and dextran sodium sulfate (DSS) administration that could be useful for the selection and characterization of potential probiotic strains to be used in inflammatory bowel disease (IBD) patients. Our strategy was based on two fundamental pillars: on the one hand, the capacity of PIE cells to create a monolayer by attaching to neighboring cells and efficiently mount inflammatory responses and, on the other hand, the use of two probiotic bifidobacteria strains that have been characterized in terms of their immunomodulatory capacities, particularly in mouse IBD models and patients. Our results demonstrated that DSS administration can alter the epithelial barrier created in vitro by PIE cells and induce a potent inflammatory response, characterized by increases in the expression levels of several inflammatory factors including TNF-α, IL-1α, CCL4, CCL8, CCL11, CXCL5, CXCL9, CXCL10, SELL, SELE, EPCAM, VCAM, NCF2, and SAA2. In addition, we demonstrated that Bifidobacterium breve M-16V and B. longum BB536 are able to regulate the C-jun N-terminal kinase (JNK) intracellular signalling pathway, reducing the DSS-induced alterations of the in vitro epithelial barrier and differentially regulating the inflammatory response in a strain-dependent fashion. The good correlation between our in vitro findings in PIE cells and previous studies in animal models and IBD patients shows the potential value of our system to select new probiotic candidates in an efficient way. more...
- Published
- 2020
30. Development and validation of the Japanese version of the team job crafting scale for nurses
- Author
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Hiroki Asaoka, Nana Sato, Asuka Sakuraya, Mako Iida, Kotaro Imamura, Kyosuke Nozawa, Kazuhiro Watanabe, and Norito Kawakami
- Subjects
Adult ,Male ,Psychometrics ,Job control ,education ,Applied psychology ,Nursing Staff, Hospital ,behavioral disciplines and activities ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Cronbach's alpha ,Japan ,Humans ,Translations ,030212 general & internal medicine ,health care economics and organizations ,General Nursing ,Patient Care Team ,030504 nursing ,Work engagement ,Reproducibility of Results ,Middle Aged ,Work Engagement ,Team nursing ,Convergent validity ,Scale (social sciences) ,Job satisfaction ,Female ,0305 other medical science ,Psychology - Abstract
Team job crafting, which refers to designing the task, relational, and cognitive aspects of a job, is thought to be beneficial for nurses working in the ward. There are no scales to assess team job crafting among nurses. This study aimed to develop and examine the reliability and validity of a scale to measure team job crafting. Based on literature reviews and interviews, potential items were created. A total of 293 nurses working on 19 wards in two hospitals in Japan were asked to complete a questionnaire twice. A series of exploratory factor analyses (EFAs) were conducted to select the final items. For convergent validity, multilevel correlations were calculated. Cronbach's α and intra-class correlation coefficients (ICCs) were calculated for reliability. A total of 190 participants responded to the baseline survey and 152 responded to the retest. The EFAs yielded a three-factor structure comprising 13 items. The three factors are task crafting considering the team's growth, cognitive crafting for members' respect and reflection of meaningfulness of work, and relational crafting for smooth information sharing. Cronbach's α ranged from .810 to .831, and test-retest ICCs ranged from 0.571 to 0.710. At the individual level, team job crafting had small-to-moderate correlations with individual levels of job crafting, job control, supervisor support, co-worker support, job satisfaction, workplace social capital, and work engagement. The ICC of the team job crafting scores of 0.125 indicated meaningful variation across wards. At the ward-level, nonsignificant but strong correlations were found with workplace social capital, job satisfaction, and psychological distress. This scale showed acceptable levels of reliability and validity. It would be useful in monitoring and improving team job crafting to increase team members' well-being and performance. more...
- Published
- 2020
31. Intention to return to the town of Tomioka in residents 7 years after the accident at Fukushima Daiichi Nuclear Power Station: a cross-sectional study
- Author
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Fumika Tateishi, Satoko Aso, Yasuyuki Taira, Takashi Kudo, Makiko Orita, Shunichi Yamashita, Nana Sato, Noboru Takamura, Keita Iyama, and Hitomi Matsunaga
- Subjects
Adult ,Male ,Fukushima Nuclear Accident ,Cross-sectional study ,Health, Toxicology and Mutagenesis ,Fukushima Daiichi Nuclear Power Station ,Logistic regression ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Risk Factors ,risk perception ,Regular Paper ,Humans ,Risk communication ,Radiology, Nuclear Medicine and imaging ,Biology ,Aged ,Aged, 80 and over ,Geography ,Middle Aged ,Radiation Exposure ,Risk perception ,Radiation exposure ,radiation ,Cross-Sectional Studies ,Logistic Models ,Fukushima daiichi ,Tomioka town ,030220 oncology & carcinogenesis ,intention to return ,Female ,Demography - Abstract
The aim of our study was to identify the factors associated with intention to return (ITR) in residents of Tomioka town, Fukushima Prefecture. We contacted approximated 8000 residents aged 20 years or older who lived in Tomioka. We invited them to take part in a written survey on ITR. In all, 1749 residents' replies were included in the analysis. We asked about ITR in former residents of Tomioka town. We also asked about relevant factors and about risk perception in relation to the health effects of radiation exposure. Of those contacted, 469 (26.8%) had an ITR. Logistic regression analysis revealed that being male (OR = 1.6, 95% Cl: 1.24-1.96, P < 0.001),the anticipation of improving shopping in the town (OR = 1.5, 95% Cl: 1.26-1.67, P < 0.001) and requests for individual consultation with experts on the health effects of radiation (OR = 2.7, 95% Cl: 2.10-3.48, P, Journal of radiation research, 60(1), pp.51-58; 2019 more...
- Published
- 2018
32. Associations of alpha-actinin-3 genotype with thigh muscle volume and physical performance in older adults with sarcopenia or pre-sarcopenia
- Author
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Ryoji Kiyama, Toshihiro Takenaka, Yuto Kiuchi, Yuki Nakai, Kazutoshi Tomioka, Takehiko Doi, Hyuma Makizako, Ayumi Wada, Yoshiaki Taniguchi, and Nana Sato
- Subjects
Male ,Sarcopenia ,Aging ,medicine.medical_specialty ,Genotype ,Timed Up and Go test ,Biochemistry ,Gastroenterology ,Grip strength ,Endocrinology ,Internal medicine ,Genetics ,medicine ,Humans ,Actinin ,Muscle, Skeletal ,Postural Balance ,Molecular Biology ,Aged ,Aged, 80 and over ,Polymorphism, Genetic ,medicine.diagnostic_test ,business.industry ,Thigh muscle ,Magnetic resonance imaging ,Cell Biology ,Physical Functional Performance ,musculoskeletal system ,medicine.disease ,Gait speed ,body regions ,Cross-Sectional Studies ,Thigh ,Physical performance ,Time and Motion Studies ,Female ,business ,human activities - Abstract
Background This cross-sectional study aimed to investigate the relationship of the ACTN3 genotype with thigh muscle volume and physical performance in older adults with sarcopenia or pre-sarcopenia. Methods Data from 64 older Japanese adults (mean age 74.4 ± 6.9 years, women 71.9%) with sarcopenia or pre-sarcopenia were analyzed. Sarcopenia and pre-sarcopenia were defined using the Asian Working Group for Sarcopenia. We collected oral mucosa samples to determine the ACTN3 genotype. Thigh muscle volumes were measured using magnetic resonance imaging. Physical performance was assessed using the usual and maximum gait speed, timed up and go test, and five-repetition sit-to-stand test. Muscle strength was assessed using grip strength. Result The ACTN3 genotype proportions were 20.3% for RR, 51.6% for RX, and 28.1% for XX. Participants with the RR genotype showed greater thigh muscle volume/ht2 compared to those with the RX and XX ACTN3 genotypes (p Conclusion The ACTN3 genotype of the X allele was associated with decreased thigh muscle volume compared to the ACTN3 genotype of RR in older adults with sarcopenia or pre-sarcopenia. more...
- Published
- 2021
- Full Text
- View/download PDF
33. Introduction to ‘Constructing Japanese translation studies’
- Author
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Nana Sato-Rossberg
- Subjects
Cultural Studies ,History ,Sociology and Political Science ,Field (Bourdieu) ,Translation studies ,Context (language use) ,Sociology ,Linguistics - Abstract
Japan has a rich tradition of research on translation, yet the discipline of Translation Studies remains somewhat underdeveloped in the Japanese context. Since the emergence of the field in the 197... more...
- Published
- 2019
- Full Text
- View/download PDF
34. Time refraction of spin waves
- Author
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Tobias Hula, P. Matthies, Katrin Schultheiss, O. Gladii, John E. Pearson, Lukas Körber, Jürgen Fassbender, Kai Wagner, Axel Hoffmann, Helmut Schultheiss, Manfred Helm, and Nana Sato
- Subjects
Length scale ,magnetization dynamics ,General Physics and Astronomy ,Physics::Optics ,FOS: Physical sciences ,spin waves ,01 natural sciences ,Light scattering ,law.invention ,Brillouin light scattering ,Optics ,time refraction ,law ,Spin wave ,Dispersion relation ,0103 physical sciences ,Mesoscale and Nanoscale Physics (cond-mat.mes-hall) ,010306 general physics ,Physics ,Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics ,business.industry ,Materials Science (cond-mat.mtrl-sci) ,Refraction ,Magnetic field ,Wavelength ,business ,Waveguide - Abstract
We present an experimental study of time refraction of spin waves propagating in microscopic waveguides under the influence of time-varying magnetic fields. Using space- and time-resolved Brillouin light scattering microscopy, we demonstrate that the broken translational symmetry along the time coordinate can be used to in- or decrease the energy of spin waves during their propagation. This allows for a broadband and controllable shift of the spin-wave frequency. Using an integrated design of spin-wave waveguide and microscopic current line for the generation of strong, nanosecond-long, magnetic field pulses, a conversion efficiency up to 39% of the carrier spin-wave frequency is achieved, significantly larger compared to photonic systems. Given the strength of the magnetic field pulses and its strong impact on the spin-wave dispersion relation, the effect of time refraction can be quantified on a length scale comparable to the spin-wave wavelength. Furthermore, we utilize time refraction to excite spin-wave bursts with pulse durations in the nanosecond range and a frequency shift depending on the pulse polarity., Comment: 5 pages, 4 figures more...
- Published
- 2020
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- View/download PDF
35. Domain wall based spin-Hall nano-oscillators (Conference Presentation)
- Author
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Jürgen Fassbender, Olav Hellwig, Nana Sato, Ahmad A. Awad, Lukas Körber, Helmut Schultheiss, Thomas Mühl, Norbert Puwenberg, Katrin Schultheiss, and Sri Sai Phani Kanth Arekapudi
- Subjects
Physics ,Domain wall (string theory) ,Presentation ,Condensed matter physics ,media_common.quotation_subject ,Nano ,Spin-½ ,media_common - Published
- 2019
- Full Text
- View/download PDF
36. Diverse Voices in Translation Studies in East Asia
- Author
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Nana Sato-Rossberg, Akiko Uchiyama, Nana Sato-Rossberg, and Akiko Uchiyama
- Subjects
- Translating and interpreting--East Asia
- Abstract
This edited volume showcases essays revolving around diverse translation discourses and practices in China, Korea and Japan. Knowledge transfer and cultural exchanges have historically flourished in East Asia and translation functions as an important social, cultural and political tool to this day. The essays in this volume discuss a wide range of historical and contemporary subjects, each examining distinctive translational activities and foregrounding their cultural significance in their respective time and place. They give a voice to various translational traditions in East Asia, where regional particularities and interlinkages are in effect. The contributors bring together different areas of expertise, such as the history of translation, political activism and translation, literary translation, transcreation and the translation profession. more...
- Published
- 2019
37. Effects of a Multicomponent Exercise Program in Physical Function and Muscle Mass in Sarcopenic/Pre-Sarcopenic Adults
- Author
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Kota Tsutsumimoto, Mitsuru Ohishi, Nana Sato, Ayumi Wada, Takuro Kubozono, Hyuma Makizako, Kazutoshi Tomioka, Yuki Nakai, Yuto Kiuchi, Ryoji Kiyama, Toshihiro Takenaka, and Yoshiaki Taniguchi
- Subjects
medicine.medical_specialty ,Flexibility (anatomy) ,lcsh:Medicine ,Physical function ,Muscle mass ,Article ,law.invention ,sarcopenia ,03 medical and health sciences ,0302 clinical medicine ,Exercise program ,Randomized controlled trial ,law ,medicine ,Aerobic exercise ,030212 general & internal medicine ,Balance (ability) ,business.industry ,lcsh:R ,General Medicine ,medicine.disease ,medicine.anatomical_structure ,Sarcopenia ,randomized controlled trial ,muscle strength ,Physical therapy ,resistance training ,business ,human activities ,030217 neurology & neurosurgery - Abstract
This study aimed to assess the effects of a multicomponent exercise program on physical function and muscle mass in older adults with sarcopenia or pre-sarcopenia. Moreover, we aim to standardize the exercise program for easy incorporation in the daily life of community-dwelling older adults as a secondary outcome. A single-blind randomized controlled trial was conducted with individuals (&ge, 60 years) who had sarcopenia or pre-sarcopenia (n = 72). Participants were randomly assigned to the exercise and control groups. The exercise program consisted of 12 weekly 60-minute sessions that included resistance, balance, flexibility, and aerobic training. Outcome measures were physical function and muscle mass. Assessments were conducted before and immediately after the intervention. Among the 72 participants (mean age: 75.0 ±, 6.9 years, 70.8% women), 67 (93.1%) completed the trial. Group-by-time interactions on the chair stand (p = 0.02) and timed &ldquo, up and go&rdquo, (p = 0.01) tests increased significantly in the exercise group. Although the exercise group showed a tendency to prevent loss of muscle mass, no significant interaction effects were observed for cross-sectional muscle area and muscle volume. The 12-week exercise program improved physical function in the intervention group. Although it is unclear whether the program is effective in increasing muscle mass, a multicomponent exercise program would be an effective treatment for physical function among older adults with sarcopenia. more...
- Published
- 2020
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38. Domain wall-based spin-Hall nano-oscillators
- Author
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Jürgen Fassbender, Thomas Mühl, Ahmad A. Awad, Lukas Körber, Helmut Schultheiss, N. Puwenberg, Nana Sato, Katrin Schultheiss, Olav Hellwig, and Sri Sai Phani Kanth Arekapudi
- Subjects
Physics ,Angular momentum ,Condensed matter physics ,Spins ,Magnetic domain ,Condensed Matter - Mesoscale and Nanoscale Physics ,General Physics and Astronomy ,FOS: Physical sciences ,01 natural sciences ,Nanomagnet ,Domain wall (magnetism) ,Ferromagnetism ,0103 physical sciences ,Mesoscale and Nanoscale Physics (cond-mat.mes-hall) ,010306 general physics ,Excitation ,Spin-½ - Abstract
In the last decade, two revolutionary concepts in nanomagnetism emerged from research for storage technologies and advanced information processing. The first suggests the use of magnetic domain walls in ferromagnetic nanowires to permanently store information in domain-wall racetrack memories. The second proposes a hardware realization of neuromorphic computing in nanomagnets using nonlinear magnetic oscillations in the gigahertz range. Both ideas originate from the transfer of angular momentum from conduction electrons to localized spins in ferromagnets, either to push data encoded in domain walls along nanowires or to sustain magnetic oscillations in artificial neurones. Even though both concepts share a common ground, they live on very different timescales which rendered them incompatible so far. Here, we bridge both ideas by demonstrating the excitation of magnetic auto-oscillations inside nanoscale domain walls using pure spin currents. This Letter will shed light on the current characteristic and spatial distribution of the excited auto-oscillations. more...
- Published
- 2019
39. Translation in oral societies and cultures
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Nana Sato-Rossberg
- Subjects
Translation (biology) ,Sociology ,Linguistics - Published
- 2018
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40. Potential Use of Thioalkylated Mannose-Modified Dendrimer (G3)/α-Cyclodextrin Conjugate as an NF-κB siRNA Carrier for the Treatment of Fulminant Hepatitis
- Author
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Irhan Ibrahim Abu Hashim, Hidetoshi Arima, Taishi Higashi, Nana Sato, Chiho Akao, Keiichi Motoyama, Takahiro Tanaka, and Ryosuke Mitsuyasu
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Lipopolysaccharides ,Male ,Dendrimers ,alpha-Cyclodextrins ,Lipopolysaccharide ,Cell Survival ,Antigen-Presenting Cells ,Pharmaceutical Science ,Mannose ,Biology ,Real-Time Polymerase Chain Reaction ,Hepatitis ,Proinflammatory cytokine ,Mice ,chemistry.chemical_compound ,In vivo ,Macrophages, Alveolar ,Drug Discovery ,medicine ,Animals ,Humans ,RNA, Small Interfering ,Fulminant hepatitis ,Drug Carriers ,Gene Transfer Techniques ,NF-kappa B ,medicine.disease ,Molecular biology ,Rats ,Mice, Inbred C57BL ,Survival Rate ,Disease Models, Animal ,chemistry ,Cell culture ,Alveolar macrophage ,Molecular Medicine - Abstract
NF-κB and its associated pathways are complicatedly concerned about hepatic homeostasis. Discriminating inhibition of NF-κB signaling has been expected to treat various liver diseases including fulminant hepatitis. To clarify the potential use of thioalkylated mannose-appended dendrimer (generation 3; G3) conjugates with α-cyclodextrin with average degree of substitution of mannose (DSM4) (Man-S-α-CDE (G3, DSM4)) as a novel antigen presenting cell (APC)-specific siRNA carrier, we evaluated the RNAi effect of NF-κB p65 siRNA (sip65) complex with Man-S-α-CDE (G3, DSM4) both in vitro and in vivo. Man-S-α-CDE (G3, DSM4)/sip65 complex significantly suppressed NF-κB p65 mRNA expression and nitric oxide (NO) production from lipopolysaccharide (LPS)-stimulated NR8383 cells, a rat alveolar macrophage cell line, by adequate physicochemical properties and mannose receptor-mediated cellular uptake. Intravenous injection of Man-S-α-CDE (G3, DSM4)/sip65 complex extended the survival rate of LPS-induced fulminant hepatitis model mice. In addition, intravenous administration of Man-S-α-CDE (G3, DSM4)/sip65 complex had the potential to induce the in vivo RNAi effect by significant suppression of mRNA expression of NF-κB p65 and inflammatory cytokines in the liver of fulminant hepatitis model mice induced by LPS/d-galactosamine (d-Gal) without any significant side effects. Also, the serum levels of enzymes were significantly attenuated by injection of Man-S-α-CDE (G3, DSM4)/sip65 complex in fulminant hepatitis model mice. Collectively, these results suggest that Man-S-α-CDE (G3, DSM4) has the potential as a novel APC-selective sip65 carrier for the treatment of LPS/d-Gal-induced fulminant hepatitis in mice. more...
- Published
- 2015
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41. Spin-wave propagation in cubic anisotropy materials
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Robert D. McMichael, Se Hyeok Oh, Seo Won Lee, Nana Sato, Kyung Jin Lee, Koji Sekiguchi, and Hiroaki Sukegawa
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010302 applied physics ,Magnonics ,Condensed Matter - Materials Science ,Materials science ,Spins ,Condensed matter physics ,Spintronics ,Materials Science (cond-mat.mtrl-sci) ,FOS: Physical sciences ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Article ,Ferromagnetism ,Spin wave ,Modeling and Simulation ,0103 physical sciences ,Group velocity ,General Materials Science ,Condensed Matter::Strongly Correlated Electrons ,0210 nano-technology ,Anisotropy ,Joule heating - Abstract
The information carrier of modern technologies is the electron charge, whose transport inevitably generates Joule heating. Spin waves, the collective precessional motion of electron spins, do not involve moving charges and thus avoid Joule heating. In this respect, magnonic devices in which the information is carried by spin waves attract interest for low-power computing. However, implementation of magnonic devices for practical use suffers from a low spin-wave signal and on/off ratio. Here, we demonstrate that cubic anisotropic materials can enhance spin-wave signals by improving spin-wave amplitude as well as group velocity and attenuation length. Furthermore, cubic anisotropic materials show an enhanced on/off ratio through a laterally localized edge mode, which closely mimics the gate-controlled conducting channel in traditional field-effect transistors. These attractive features of cubic anisotropic materials will invigorate magnonics research towards wave-based functional devices. more...
- Published
- 2017
42. Transcriptomic Analysis of the Innate Antiviral Immune Response in Porcine Intestinal Epithelial Cells: Influence of Immunobiotic Lactobacilli
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Hikaru Iida, Julio Villena, Tomonori Nochi, Susana Salva, Hisashi Aso, Haruki Kitazawa, Leonardo Albarracin, Susana Alvarez, Nana Sato, and Hisakazu Kobayashi
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0301 basic medicine ,Chemokine ,CIENCIAS MÉDICAS Y DE LA SALUD ,Immunology ,Inmunología ,CCL5 ,Microbiology ,antiviral response ,Transcriptome ,03 medical and health sciences ,Immune system ,Lactobacillus rhamnosus ,LACTOBACILLUS PLANTARUM CRL1506 ,immunotranscriptomic response ,Immunology and Allergy ,CXCL10 ,IMMUNOTRANSCRIPTOMIC RESPONSE ,TLR3 ,Original Research ,Lactobacillus plantarum CRL1506 ,biology ,ANTIVIRAL RESPONSE ,LACTOBACILLUS RHAMNOSUS CRL1505 ,purl.org/becyt/ford/3.1 [https] ,biology.organism_classification ,Medicina Básica ,030104 developmental biology ,Gene chip analysis ,biology.protein ,Lactobacillus rhamnosus CRL1505 ,purl.org/becyt/ford/3 [https] ,intestinal epithelial cells ,INTESTINAL EPITHELIAL CELLS - Abstract
Lactobacillus rhamnosus CRL1505 and Lactobacillus plantarum CRL1506 are immunobiotic strains able to increase protection against viral intestinal infections as demonstrated in animal models and humans. To gain insight into the host-immunobiotic interaction, the transcriptomic response of porcine intestinal epithelial (PIE) cells to the challenge with viral molecular associated pattern poly(I:C) and the changes in the transcriptomic profile induced by the immunobiotics strains CRL1505 and CRL1506 were investigated in this work. By using microarray technology and reverse transcription PCR, we obtained a global overview of the immune genes involved in the innate antiviral immune response in PIE cells. Stimulation of PIE cells with poly(I:C) significantly increased the expression of IFN-α and IFN-β, several interferon-stimulated genes, cytokines, chemokines, adhesion molecules, and genes involved in prostaglandin biosynthesis. It was also determined that lactobacilli differently modulated immune gene expression in poly(I:C)-challenged PIE cells. Most notable changes were found in antiviral factors (IFN-α, IFN-β, NPLR3, OAS1, OASL, MX2, and RNASEL) and cytokines/chemokines (IL-1β, IL-6, CCL4, CCL5, and CXCL10) that were significantly increased in lactobacilli-treated PIE cells. Immunobiotics reduced the expression of IL-15 and RAE1 genes that mediate poly(I:C) inflammatory damage. In addition, lactobacilli treatments increased the expression PLA2G4A, PTGES, and PTGS2 that are involved in prostaglandin E2 biosynthesis. L. rhamnosus CRL1505 and L. plantarum CRL1506 showed quantitative and qualitative differences in their capacities to modulate the innate antiviral immune response in PIE cells, which would explain the higher capacity of the CRL1505 strain when compared to CRL1506 to protect against viral infection and inflammatory damage in vivo. These results provided valuable information for the deeper understanding of the host-immunobiotic interaction and their effect on antiviral immunity. The comprehensive transcriptomic analyses successfully identified a group of genes (IFN-β, RIG1, RNASEL, MX2, A20, IL27, CXCL5, CCL4, PTGES, and PTGER4), which can be used as prospective biomarkers for the screening of new antiviral immunobiotics in PIE cells and for the development of novel functional food and feeds, which may help to prevent viral infections. Fil: Albarracín, Leonardo Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina. Tohoku University; Japón Fil: Kobayashi, Hisakazu. Tohoku University; Japón Fil: Iida, Hikaru. Tohoku University; Japón Fil: Sato, Nana. Tohoku University; Japón Fil: Nochi, Tomonori. Tohoku University; Japón Fil: Aso, Hisashi. Tohoku University; Japón Fil: Salva, Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina Fil: Alvarez, Gladis Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina Fil: Kitazawa, Haruki. Tohoku University; Japón Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina more...
- Published
- 2017
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43. Potential use of fucose-appended dendrimer/α-cyclodextrin conjugates as NF-κB decoy carriers for the treatment of lipopolysaccharide-induced fulminant hepatitis in mice
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Nana Sato, Hidetoshi Arima, Risako Onodera, Taishi Higashi, Keiichi Motoyama, Chiho Akao, Ayumu Ohyama, and Takahiro Tanaka
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Lipopolysaccharides ,Male ,Dendrimers ,alpha-Cyclodextrins ,Lipopolysaccharide ,Cell Survival ,Surface Properties ,Pharmaceutical Science ,Nitric Oxide ,Fucose ,Cell Line ,chemistry.chemical_compound ,Liver Function Tests ,Macrophages, Alveolar ,medicine ,Animals ,Fulminant hepatitis ,Drug Carriers ,Molecular Structure ,Tumor Necrosis Factor-alpha ,Kupffer cell ,NF-κB ,Liver Failure, Acute ,Molecular biology ,Rats ,Mice, Inbred C57BL ,Disease Models, Animal ,medicine.anatomical_structure ,Oligodeoxyribonucleotides ,chemistry ,Biochemistry ,Alveolar macrophage ,Tumor necrosis factor alpha ,Decoy - Abstract
The purpose of the present study is to treat lipopolysaccharide (LPS)-induced fulminant hepatitis by NF-κB decoy complex with fucose-appended dendrimer (generation 2; G2) conjugate with α-cyclodextrin (Fuc-S-α-CDE (G2)). Fuc-S-α-CDE (G2, average degree of substitution of fucose (DSF2))/NF-κB decoy complex significantly suppressed nitric oxide and tumor necrosis factor-α (TNF-α) production from LPS-stimulated NR8383 cells, a rat alveolar macrophage cell line, by adequate physicochemical properties and fucose receptor-mediated cellular uptake. Intravenous injection of Fuc-S-α-CDE (G2, DSF2)/NF-κB decoy complex extended the survival of LPS-induced fulminant hepatitis model mice. In addition, Fuc-S-α-CDE (G2, DSF2)/NF-κB decoy complex administered intravenously highly accumulated in the liver, compared to naked NF-κB decoy alone. Furthermore, the liver accumulation of Fuc-S-α-CDE (G2, DSF2)/NF-κB decoy complex was inhibited by the pretreatment with GdCl3, a specific inhibitor of Kupffer cell uptake. Also, the serum aspartate aminotransferase, alanine aminotransferase and TNF-α levels in LPS-induced fulminant hepatitis model mice were significantly attenuated by the treatment with Fuc-S-α-CDE (G2, DSF2)/NF-κB decoy complex, compared with naked NF-κB decoy alone. Taken together, these results suggest that Fuc-S-α-CDE (G2, DSF2) has the potential for a novel Kupffer cell-selective NF-κB decoy carrier for the treatment of LPS-induced fulminant hepatitis in mice. more...
- Published
- 2014
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44. Seven years post-Fukushima: overcoming the resident–specialist gap
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Makiko Orita, Noboru Takamura, Nana Sato, and Yasuyuki Taira
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Radiation ,Fukushima Nuclear Accident ,Health, Toxicology and Mutagenesis ,MEDLINE ,Radiation Exposure ,medicine.disease ,Letter to Editor ,Radiation exposure ,03 medical and health sciences ,0302 clinical medicine ,Residence Characteristics ,Surveys and Questionnaires ,030220 oncology & carcinogenesis ,Political science ,Specialization (functional) ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Medical emergency ,030217 neurology & neurosurgery ,Specialization - Published
- 2018
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45. Efficient Anticancer Drug Delivery for Pancreatic Cancer Treatment Utilizing Supramolecular Polyethylene-Glycosylated Bromelain.
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Taishi Higashi, Tetsuya Kogo, Nana Sato, Tatsunori Hirotsu, Shogo Misumi, Hideaki Nakamura, Daisuke Iohara, Risako Onodera, Keiichi Motoyama, and Hidetoshi Arima
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- 2020
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46. Excitation of Continuous Magnetostatic Surface Spin Wavein Ferromagnetic Thin Films
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Nana Sato, Yukio Nozaki, and Koji Sekiguchi
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Spin pumping ,Materials science ,Spintronics ,Spin polarization ,Condensed matter physics ,Ferromagnetic material properties ,Magnon ,Condensed Matter Physics ,Electronic, Optical and Magnetic Materials ,Spin wave ,Electrical and Electronic Engineering ,Spin (physics) ,Instrumentation ,Excitation - Published
- 2013
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47. Multiple Translation Communities in Contemporary Japan
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Beverley Curran, Nana Sato-Rossberg, Kikuko Tanabe, Beverley Curran, Nana Sato-Rossberg, and Kikuko Tanabe
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- Translating and interpreting--Japan
- Abstract
Multiple Translation Communities in Contemporary Japan offers a collection of essays that (1) deepens the understanding of the cultural and linguistic diversity of communities in contemporary Japan and how translation operates in this shifting context and circulates globally by looking at some of the ways it is theorized and approached as a significant social, cultural, or political practice, and harnessed by its multiple agents; (2) draws attention to the multi-platform translations of cultural productions such as manga, which are both particular to and popular in Japan but also culturally influential and widely circulated transnationally; (3) poses questions about the range of roles translation has in the construction, performance, and control of gender roles in Japan, and (4) enriches Translation Studies by offering essays that problematize critical notions related to translation. In short, the essays in this book highlight the diversity and ubiquity of translation in Japan as well as the range of methods being used to understand how it is being theorized, positioned, and practiced. more...
- Published
- 2015
48. Imidazoline 1 receptor activation preserves respiratory drive in spontaneously breathing newborn rats during dexmedetomidine administration
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Toshio Imai, Chikako Saiki, Katsuhisa Sunada, Nana Sato, and Junko Tamiya
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Agonist ,medicine.drug_class ,Imidazoline receptor ,Body Temperature ,03 medical and health sciences ,chemistry.chemical_compound ,Electrocardiography ,0302 clinical medicine ,030202 anesthesiology ,Heart Rate ,Pregnancy ,Adrenergic alpha-2 Receptor Agonists ,Medicine ,Animals ,Hypnotics and Sedatives ,Dexmedetomidine ,Rats, Wistar ,Drive ,business.industry ,Respiration ,Atipamezole ,Adrenergic alpha-2 Receptor Antagonists ,Efaroxan ,Receptor antagonist ,Rats ,Plethysmography ,Anesthesiology and Pain Medicine ,chemistry ,Isoflurane ,Animals, Newborn ,Anesthesia ,Pediatrics, Perinatology and Child Health ,Breathing ,Female ,Imidazoline Receptors ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
SummaryBackground Dexmedetomidine is an alpha-2 (α2) adrenoceptor and imidazoline 1 (I1) receptor agonist that provides sedation without loss of respiratory drive. Aims The aim of this study was to elucidate the involvement of α2-adrenoceptor and I1 receptor in the cardiorespiratory changes induced by dexmedetomidine in spontaneously breathing newborn rats. Methods An abdominal catheter to administer drugs and three subcutaneous electrodes to record electrocardiographic data were inserted into 2- to 5-day-old Wistar rats under isoflurane anesthesia. In individual chambers, each rat was intraperitoneally administered dexmedetomidine (50 μg·kg−1) followed 5 min later by normal saline or 1, 5, or 10 mg·kg−1 atipamezole (selective α2-adrenoceptor antagonist) or efaroxan (α2-adrenoceptor/I1 receptor antagonist). Cardiorespiratory indices were recorded before and after drug administration. Results The administration of dexmedetomidine alone resulted in significant changes to most of the cardiorespiratory indices examined. The addition of 5 or 10 mg·kg−1 atipamezole or 1 mg·kg−1 efaroxan completely ameliorated the dexmedetomidine-associated reduction in heart rate (HR). The addition of 1 mg·kg−1 atipamezole or 1 or 5 mg·kg−1 efaroxan completely ameliorated the dexmedetomidine-associated reduction in respiratory frequency. Mean inspiratory flow (VT/TI; VT is tidal volume and TI is inspiratory time), which is an index of respiratory drive, was not significantly affected by the administration of dexmedetomidine alone (P = 0.273) or dexmedetomidine + atipamezole (P = 0.605, 0.153, 0.138 for 1, 5, 10 mg·kg−1 atipamezole, respectively); however, it was significantly decreased after the administration of dexmedetomidine + efaroxan (P = 0.029 more...
- Published
- 2016
49. Draft genome sequence of Lactobacillus plantarum TL2766, a strain with the ability to ferment wakame
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Julio Villena, Yuki Masumizu, Leonardo Albarracin, Wakako Ikeda-Ohtsubo, Seiya Makino, Nana Sato, Lucila Saavedra, Elvira Maria Hebert, Katsunori Kimura, Haruki Kitazawa, Sou Ohkawara, and A. K. M. Humayun Kober more...
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0301 basic medicine ,Genetics ,Whole genome sequencing ,WAKAME ,Contig ,biology ,LACTOBACILLUS PLANTARUM TL2766 ,Strain (biology) ,Otras Ciencias Biológicas ,food and beverages ,Undaria pinnatifida ,biology.organism_classification ,Genome ,Microbiology ,Ciencias Biológicas ,03 medical and health sciences ,030104 developmental biology ,DRAFT GENOME SEQUENCE ,Prokaryotes ,Molecular Biology ,Lactobacillus plantarum ,CIENCIAS NATURALES Y EXACTAS - Abstract
The genome sequence of Lactobacillus plantarum TL2766, a strain with the ability to ferment wakame (Undaria pinnatifida), is described here. The reads were assembled into contigs, with a total size of 3,310,195 bp. The genome information will be useful for further specific genetic studies of this strain and for its biotechnological applications. Fil: Villena, Julio Cesar. Tohoku University. Food and Feed Immunology Group; Japón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina Fil: Saavedra, Maria Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina Fil: Hebert, Elvira Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina Fil: Masumizu, Yuki. Tohoku University. Food and Feed Immunology Group; Japón Fil: Sato, Nana. Tohoku University. Food and Feed Immunology Group; Japón Fil: Kober, Humayun A. K. M.. Tohoku University. Food and Feed Immunology Group; Japón Fil: Albarracín, Leonardo Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina. Tohoku University. Food and Feed Immunology Group; Japón Fil: Ikeda Ohtsubo, Wakako. Tohoku University. Food and Feed Immunology Group; Japón Fil: Makino, Seiya. Meiji Co. Ltd. Food Science Research Laboratories; Japón Fil: Kimura, Katsunori. Meiji Seika Pharma Co., Ltd. Agricultural & Veterinary Division; Japón Fil: Ohkawara, Sou. Meiji Seika Pharma Co., Ltd. Agricultural & Veterinary Division; Japón Fil: Kitazawa, Haruki. Tohoku University. Food and Feed Immunology Group; Japón more...
- Published
- 2016
50. Modulation of porcine intestinal epitheliocytes immunetranscriptome response by Lactobacillus jensenii TL2937
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Wakako Ikeda-Ohtsubo, Tomonori Nochi, Leonardo Albarracin, Julio Villena, Hiroshi Kano, Nana Sato, Sou Ohkawara, Akm Humayun Kober, Yoshihito Suda, Tadao Saito, Hisashi Aso, Seiya Makino, Hisakazu Kobayashi, Paulraj Kanmani, and Haruki Kitazawa more...
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0301 basic medicine ,Microbiology (medical) ,Chemokine ,CIENCIAS MÉDICAS Y DE LA SALUD ,Swine ,Inmunología ,LACTOBACILLUS JENSENII TL2937 ,medicine.disease_cause ,Microbiology ,law.invention ,Cell Line ,Immunomodulation ,03 medical and health sciences ,Probiotic ,law ,Lactobacillus ,Enterotoxigenic Escherichia coli ,medicine ,Animals ,IMMUNOTRANSCRIPTOMIC RESPONSE ,Inflammation ,Epitheliocyte ,PORCINE INTESTINAL EPITHELIOCYTES ,biology ,ETEC ,Lactobacillus jensenii ,Probiotics ,Epithelial Cells ,purl.org/becyt/ford/3.1 [https] ,Complement System Proteins ,Blood coagulation factors ,biology.organism_classification ,Blood Coagulation Factors ,Intestines ,Medicina Básica ,030104 developmental biology ,IMMUNOBIOTIC BIOMARKERS ,Cell culture ,biology.protein ,purl.org/becyt/ford/3 [https] ,Chemokines ,Transcriptome - Abstract
In order to evaluate probiotic strains applicable for the beneficial immunomodulation of the porcine gut (immunobiotics), we previously developed a porcine intestinal epitheliocyte cell line (PIE cells). Here, transcriptomic studies using PIE cells were performed considering that this information would be valuable for understanding the mechanisms involved in the protective activity of the immunobiotic strain Lactobacillus jensenii TL2937 against intestinal inflammatory damage in pigs. In addition, those studies would provide criteria for selecting biomarkers for the screening of new immunobiotic strains. We performed microarray analysis to investigate the transcriptomic response of PIE cells to the challenge with heat-stable Enterotoxigenic Escherichia coli (ETEC) pathogen-associated molecular patterns (PAMPs) and, the changes induced by L. jensenii TL2937 in that response. The approach allowed us to obtain a global overview of the immune genes involved in the response of PIE cells to heat-stable ETEC PAMPs. We observed that L. jensenii TL2937 differently modulated gene expression in ETEC PAMPs-challenged PIE cells. Microarray and RT-PCR analysis indicated that the most remarkable changes in PIE cells transcriptomic profile after heat-stable ETEC PAMPs challenge were observed in chemokines, adhesion molecules, complement and coagulation cascades factors. In addition, an anti-inflammatory effect triggered by TL2937 strain in PIE cells was clearly demonstrated. The decrease in the expression of chemokines (CCL8, CXCL5, CXCL9, CXCL10, and CXCL11), complement (C1R, C1S, C3, and CFB), and coagulation factors (F3) by L. jensenii TL2937 supports our previous reports on the immunoregulatory effect of this strain. These results provided clues for the better understanding of the mechanism underlying host-immunobiotic interaction in the porcine host. The comprehensive transcriptomic profiles of PIE cells provided by our analyses successfully identified a group of genes, which could be used as prospective biomarkers for the screening and evaluation of new anti-inflammatory immunobiotics for the prevention of inflammatory intestinal disorders in pigs. Fil: Kobayashi, Hisakazu. Tohoku University; Japón Fil: Albarracín, Leonardo Miguel. Tohoku University; Japón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina Fil: Sato, Nana. Tohoku University; Japón Fil: Kanmani, Paulraj. Tohoku University; Japón Fil: Kober, Humayun A.K.M.. Tohoku University; Japón. Chittagong Veterinary and Animal Sciences University. Department of Dairy and Poultry Science; Bangladesh Fil: Ikeda-Ohtsubo, Wakako. Tohoku University; Japón Fil: Suda, Yoshihito. Miyagi University; Japón Fil: Nochi, Tomonori. Tohoku University; Japón Fil: Aso, Hisashi. Tohoku University; Japón Fil: Makino, Seiya. Meiji Co., Ltd. Food Science Research Labs.; Japón Fil: Kano, Hiroshi. Meiji Co., Ltd. Food Science Research Labs.; Japón Fil: Ohkawara, Sou. Meiji Seika Pharma Co., Ltd. Agricultural and Veterinary Division; Japón Fil: Saito, Tadao. Tohoku University; Japón Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Tohoku University; Japón Fil: Kitazawa, Haruki. Tohoku University; Japón more...
- Published
- 2016
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