19 results on '"Nancy Mervish"'
Search Results
2. Phthalate Exposure Across Pregnancy: Can We Use a Single Measure to Stand in for Exposure?
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Chris Gennings, Ronald J. Wapner, Autumn M. Clemons, John D. Meeker, Shabnaz Siddiq, Nancy Mervish, Pam Factor Litvak, and Virginia Rauh
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Single measure ,Pregnancy ,chemistry.chemical_compound ,chemistry ,business.industry ,medicine ,Phthalate ,General Earth and Planetary Sciences ,Physiology ,medicine.disease ,business ,General Environmental Science - Published
- 2021
3. Predictors of phthalate metabolites exposure among healthy pregnant women in the United States
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Ronald J. Wapner, Nancy Mervish, Chris Gennings, Virginia Rauh, Pam Factor Litvak, John D. Meeker, Autumn M. Clemons, and Shabnaz Siddiq
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chemistry.chemical_compound ,chemistry ,business.industry ,Phthalate ,General Earth and Planetary Sciences ,Physiology ,Medicine ,business ,General Environmental Science - Published
- 2021
4. Phthalate metabolite exposure during pregnancy and risk of preeclampsia in an ethnically diverse nulliparous pregnancy cohort in the United States
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Chris Gennings, Autumn M. Clemons, Nancy Mervish, John D. Meeker, Shabnaz Siddiq, Ronald J. Wapner, Virginia Rauh, and Pam Factor Litvak
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medicine.medical_specialty ,Pregnancy ,Obstetrics ,business.industry ,Cohort ,medicine ,General Earth and Planetary Sciences ,Phthalate metabolite ,Ethnically diverse ,medicine.disease ,business ,General Environmental Science ,Preeclampsia - Published
- 2021
5. Human Health Exposure Analysis Resource (HHEAR): A model for incorporating the exposome into health studies
- Author
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Robert O. Wright, Susan Marie Viet, Lori S. Merrill, Elaine M. Faustman, David A. Savitz, Lisa A. Peterson, Barbara O'Brien, Nancy Mervish, Jill C. Falman, Dana B. Barr, and David M. Balshaw
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Exposome ,Computer science ,Public Health, Environmental and Occupational Health ,Sample (statistics) ,Environmental Exposure ,Environmental exposure ,010501 environmental sciences ,Ontology (information science) ,01 natural sciences ,Data science ,Article ,Data sharing ,03 medical and health sciences ,0302 clinical medicine ,Resource (project management) ,Research Design ,ACROSS Project ,Health Resources ,Humans ,030212 general & internal medicine ,Environmental Health ,0105 earth and related environmental sciences ,Exposure assessment - Abstract
Background Characterizing the complexity of environmental exposures in relation to human health is critical to advancing our understanding of health and disease throughout the life span. Extant cohort studies open the door for such investigations more rapidly and inexpensively than launching new cohort studies and the Human Health Exposure Analysis Resource (HHEAR) provides a resource for implementing life-stage exposure studies within existing study populations. Primary challenges to incorporation of environmental exposure assessment in health studies include: (1) lack of widespread knowledge of biospecimen and environmental sampling and storage requirements for environmental exposure assessment among investigators; (2) lack of availability of and access to laboratories capable of analyzing multiple environmental exposures throughout the life-course; and (3) studies lacking sufficient power to assess associations across life-stages. HHEAR includes a consortium of researchers with expertise in laboratory analyses, statistics and logistics to overcome these limitations and enable inclusion of exposomics in human health studies. Objective This manuscript describes the structure and strengths of implementing the harmonized HHEAR resource model, and our approaches to addressing challenges. We describe how HHEAR incorporates analyses of biospecimens and environmental samples and human health studies across the life span - serving as a model for incorporating environmental exposures into national and international research. We also present program successes to date. Discussion HHEAR provides a full-service laboratory and data analysis exposure assessment resource, linking scientific, life span, and toxicological consultation with both laboratory and data analysis expertise. HHEAR services are provided without cost but require NIH, NCI, NHLBI, or ECHO funding of the original cohort; internal HHEAR scientific review and approval of a brief application; and adherence to data sharing and publication policies. We describe the benefits of HHEAR's structure, collaborative framework and coordination across project investigators, analytical laboratories, biostatisticians and bioinformatics specialists; quality assurance/quality control (QA/QC) including integrated sample management; and tools that have been developed to support the research (exposure information pages, ontology, new analytical methods, common QA/QC approach across laboratories, etc.). This foundation supports HHEAR's inclusion of new laboratory and statistical analysis methods and studies that are enhanced by including targeted analysis of specific exposures and untargeted analysis of chemicals associated with phenotypic endpoints in biological and environmental samples. Conclusion HHEAR is an interdisciplinary team of toxicologists, epidemiologists, laboratory scientists, and data scientists across multiple institutions to address broad and complex questions that benefit from integrated laboratory and data analyses. HHEAR's processes, features, and tools include all life stages and analysis of biospecimens and environmental samples. They are available to the wider scientific community to augment studies by adding state of the art environmental analyses to be linked to human health outcomes.
- Published
- 2021
6. Peripubertal dietary flavonol and lignan intake and age at menarche in a longitudinal cohort of girls
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Lawrence H. Kushi, Mary S. Wolff, Susan M. Pinney, Ashley Pajak, Gayle C. Windham, Nancy Mervish, Frank M. Biro, and Susan L. Teitelbaum
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0301 basic medicine ,medicine.medical_specialty ,Flavonols ,Physiology ,Overweight ,Lignans ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Longitudinal Studies ,030212 general & internal medicine ,Child ,Prospective cohort study ,Proportional Hazards Models ,Menarche ,030109 nutrition & dietetics ,Proportional hazards model ,business.industry ,Hazard ratio ,Confidence interval ,Diet ,Endocrinology ,chemistry ,Pediatrics, Perinatology and Child Health ,Female ,Phytoestrogens ,medicine.symptom ,business ,Body mass index - Abstract
BackgroundDietary phytoestrogens may alter hormonal activity in childhood. Flavonols and lignans are the most prevalent phytoestrogens in the Western diet. We examined whether higher intake of flavonols and lignans was associated with later age at menarche in a prospective study of young girls.MethodsIn all, 1,044 girls aged 6-8 years (mean 7.3 years) with two to four 24-h dietary recalls during their baseline year were followed up for 11 years until the attainment of menarche in the Breast Cancer and Environment Research Project (BCERP). Associations of age at menarche with quintiles of phytoestrogens were assessed using hazard ratios (HR) and 95% confidence intervals (CIs) from Cox proportional hazards models, controlling for body mass index and other covariates.ResultsThe highest quintile of flavonol intake was associated with a later age at menarche, compared with the lowest quintile (adjusted HR: 0.80, 95% CI: (0.66-1.00). For lignans, there was a later age in overweight girls (HR: 0.56, 95% CI=0.40-0.80).ConclusionThese dietary bioactives may reflect a healthy diet, and foods high in phytoestrogens may influence the timing of menarche.
- Published
- 2017
7. Big and disparate data: considerations for pediatric consortia
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Deborah L. McGuinness, Patricia Kovatch, Nancy Mervish, Jeanette A. Stingone, Susan L. Teitelbaum, and Chris Gennings
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Male ,Exposure disease ,Big data ,Information Dissemination ,MEDLINE ,Information Storage and Retrieval ,010501 environmental sciences ,Pediatrics ,01 natural sciences ,Article ,Access to Information ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,030212 general & internal medicine ,Set (psychology) ,0105 earth and related environmental sciences ,Delivery of Health Care, Integrated ,business.industry ,Pediatric research ,Child Health ,food and beverages ,Data science ,United States ,Disparate system ,Work (electrical) ,Communicable Disease Control ,Pediatrics, Perinatology and Child Health ,Female ,business - Abstract
Purpose of review Increasingly, there is a need for examining exposure disease associations in large, diverse datasets to understand the complex determinants of pediatric disease and disability. Recognizing that children's health research consortia will be important sources of big data, it is crucial for the pediatric research community to be knowledgeable about the challenges and opportunities that they will face. The present review will provide examples of existing children's health consortia, highlight recent pooled analyses conducted by children's health research consortia, address common challenges of pooled analyses, and provide recommendations to advance collective research efforts in pediatric research. Recent findings Formal consortia and other collective-science initiatives are increasingly being created to share individual data from a set of relevant epidemiological studies to address a common research topic under the concept that the joint effort of many individual groups can accomplish far more than working alone. There are practical challenges to the participation of investigators within consortia that need to be addressed in order for them to work. Summary Researchers who access consortia with data centers will be able to go far beyond their initial hypotheses and potentially accomplish research that was previously thought infeasible or too costly.
- Published
- 2017
8. Thyroid Antagonists (Perchlorate, Thiocyanate, and Nitrate) and Childhood Growth in a Longitudinal Study of U.S. Girls
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Gayle C. Windham, Frank M. Biro, Ashley Pajak, Nancy Mervish, Benjamin C. Blount, Susan L. Teitelbaum, Liza Valentin-Blasini, Mary S. Wolff, Susan M. Pinney, and Lawrence H. Kushi
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0301 basic medicine ,endocrine system diseases ,Health, Toxicology and Mutagenesis ,medicine.medical_treatment ,Iodide ,California ,Body Mass Index ,chemistry.chemical_compound ,Perchlorate ,Child Development ,0302 clinical medicine ,Longitudinal Studies ,Child ,health care economics and organizations ,2. Zero hunger ,chemistry.chemical_classification ,Perchlorates ,Symporters ,Antithyroid agent ,Thyroid ,food and beverages ,3. Good health ,medicine.anatomical_structure ,Children's Health ,Female ,Waist Circumference ,Thyroid function ,Iodine ,endocrine system ,medicine.medical_specialty ,Adolescent ,Sodium ,chemistry.chemical_element ,03 medical and health sciences ,Antithyroid Agents ,030225 pediatrics ,Internal medicine ,medicine ,Humans ,Ohio ,Nitrates ,Thiocyanate ,030111 toxicology ,Public Health, Environmental and Occupational Health ,Body Height ,Endocrinology ,chemistry ,Symporter ,New York City ,Thiocyanates - Abstract
Background: Perchlorate, thiocyanate, and nitrate are sodium/iodide symporter (NIS) inhibitors that block iodide uptake into the thyroid, thus affecting thyroid function. Thyroid dysfunction can adversely affect somatic growth and development in children. To our knowledge, no studies have examined effects of NIS inhibitors on body size measures. Objective: We investigated associations between NIS inhibitors and childhood growth in 940 girls from the Puberty Study of the Breast Cancer and Environment Research Program. Methods: Urine samples collected from girls 6–8 years of age at enrollment (2004–2007) from New York City, greater Cincinnati, Ohio, and the Bay Area in California were analyzed for NIS inhibitors and creatinine (C). The longitudinal association between NIS inhibitors and anthropometric measures [height, waist circumference, and body mass index (BMI)] during at least three visits was examined using mixed effects linear models, adjusted for race and site. Results: Compared with girls in the low-exposure group (3.6, 626, and 500 mg/gC, median perchlorate, thiocyanate, and nitrate, respectively) girls with the highest NIS inhibitor exposure (9.6, 2,343, and 955 mg/gC, median perchlorate, thiocyanate, and nitrate, respectively) had slower growth in waist circumference and BMI but not height. Significant differences in the predicted mean waist circumference and BMI between the low- and high-exposure groups were observed beginning at 11 years of age. Conclusions: Higher NIS inhibitor exposure biomarkers were associated with reductions in waist circumference and BMI. These findings underscore the need to assess exposure to NIS inhibitors with respect to their influence on childhood growth. Citation: Mervish NA, Pajak A, Teitelbaum SL, Pinney SM, Windham GC, Kushi LH, Biro FM, Valentin-Blasini L, Blount BC, Wolff MS, for the Breast Cancer and Environment Research Project (BCERP). 2016. Thyroid antagonists (perchlorate, thiocyanate, and nitrate) and childhood growth in a longitudinal study of U.S. girls. Environ Health Perspect 124:542–549; http://dx.doi.org/10.1289/ehp.1409309
- Published
- 2016
9. Dietary and Physical Activity Behaviors of New York City Children From Different Ethnic Minority Subgroups
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Barbara Brenner, Mary S. Wolff, Maida P. Galvez, Nita Vangeepuram, and Nancy Mervish
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Male ,Gerontology ,Cross-sectional study ,Health Behavior ,Physical activity ,Ethnic group ,Motor Activity ,Mexican americans ,Article ,Mexican Americans ,Ethnicity ,medicine ,Humans ,Obesity ,Motor activity ,Child ,Minority Groups ,Sedentary lifestyle ,Dominican Republic ,Puerto Rico ,Hispanic or Latino ,medicine.disease ,Diet ,Black or African American ,Cross-Sectional Studies ,Multivariate Analysis ,Pediatrics, Perinatology and Child Health ,Female ,New York City ,Sedentary Behavior ,Health behavior ,Psychology - Abstract
To examine racial/ethnic differences in diet and physical activity behaviors in ethnic minority New York City children.Cross-sectional data from a community-based study of 486 6- to 8-year-old children were used. Race/ethnicity was derived using a caregiver's report of child's race and Hispanic ancestry. Dietary intake was obtained by 24-hour diet recalls using the Nutrition Data System for Research. Physical activity was assessed with pedometers and caregiver interviews. We compared diet and activity measures across racial/ethnic subgroups using chi-square and analysis of variance tests. Multivariate analyses adjusted for age, gender, body mass index, and caregiver education (with breastfeeding history and total energy intake included in diet models).Participants (N = 486) were categorized as Mexican (29.4%), Dominican (8.4%), Puerto Rican (20.6%), other/mixed Hispanic (14.0%), or non-Hispanic black (27.6%). Obesity rates were lower in non-Hispanic blacks (18%) than in Hispanics (31%). Mexicans had the lowest obesity rates among Hispanic subgroups (25%), and Dominicans had the highest (39%). There were differences in mean daily servings of food groups, with Mexicans having healthier diets and Puerto Ricans and non-Hispanic Blacks having less healthy diets. Sedentary time was lower in Mexicans than in other groups in adjusted models. Examination of additional models, including home language, did not show significant differences in the estimates.Diet and activity behaviors varied across racial/ethnic subgroups. Specifically, Mexican children had healthier diets, the least amount of sedentary time, and the lowest rates of obesity among the Hispanic subgroups examined. Targeted interventions in ethnic subgroups may be warranted to address specific behaviors.
- Published
- 2012
10. Associations between phthalate metabolite urinary concentrations and body size measures in New York City children
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Susan L. Teitelbaum, Antonia M. Calafat, Nita Vangeepuram, Maida P. Galvez, Manori J. Silva, Mary S. Wolff, Barbara Brenner, Erin Moshier, and Nancy Mervish
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Male ,medicine.medical_specialty ,Urinary system ,Phthalic Acids ,Physiology ,Phthalate metabolite ,Body size ,Biochemistry ,Article ,Cohort Studies ,Internal medicine ,medicine ,Body Size ,Humans ,Prospective Studies ,Child ,General Environmental Science ,Dose-Response Relationship, Drug ,business.industry ,Extramural ,Follow up studies ,Data interpretation ,Hispanic or Latino ,medicine.disease ,Obesity ,Black or African American ,Endocrinology ,Data Interpretation, Statistical ,Environmental Pollutants ,Female ,New York City ,business ,Body mass index ,Follow-Up Studies - Abstract
To examine prospectively associations between urinary phthalate metabolite concentrations and body size measures in children.Urinary concentrations of nine phthalate metabolites: monoethyl (MEP); mono-n-butyl (MBP); mono-(3-carboxypropyl) (MCPP); monobenzyl (MBzP); mono-isobutyl (MiBP); mono-(2-ethylhexyl) (MEHP); mono-(2-ethyl-5-oxohexyl) (MEOHP); mono-(2-ethyl-5-carboxypentyl) (MECPP); and mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and the molar sum of the low molecular-weight phthalate metabolites (low MWP: MEP, MBP and MiBP) and high molecular-weight phthalate metabolites (high MWP: MECPP, MEHHP, MEOHP, MEHP and MBzP) and of four di-(2-ethylhexyl) phthalate (DEHP) metabolites (ΣDEHP: MEHP, MEHHP, MEOHP, MECPP) and anthropometry, including body mass index and waist circumference were measured among 387 Hispanic and Black, New York City children who were between six and eight years at cohort enrollment (2004-2007). Relationships between baseline metabolite concentrations and body size characteristics obtained one year later were examined using multivariate-adjusted geometric means for each body size characteristic by continuous and categories of phthalate metabolite concentrations. Stratified analyses by body size (age/sex specific) were conducted.No significant associations are reported among all girls or boys. Dose response relationships were seen with monoethyl phthalate and the sum of low molecular-weight phthalates and body mass index and waist circumference among overweight children; for increasing monoethyl phthalate concentration quartiles among girls, adjusted mean body mass indexes were as follows: 21.3, 21.7, 23.8, 23.5 and adjusted mean waist circumference (cm) were as follows: 73.4, 73.5, 79.2, 78.8 (p-trend0.001 for both).In this prospective analysis we identified positive relationships between urinary concentrations of monoethyl phthalate and the sum of low molecular-weight phthalates and body size measures in overweight children. These are metabolites with concentrations above 1 μM.
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- 2012
11. Mercury derived from dental amalgams and neuropsychologic function
- Author
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Jennie Kline, Jamie K. Geier, Sonia Schoenholtz, Gunnar Hasselgren, Nancy Mervish, Melissa D. Begg, Diane M. Jacobs, Pam Factor-Litvak, and Joseph H. Graziano
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Adult ,Male ,Cross-sectional study ,Health, Toxicology and Mutagenesis ,Dentistry ,chemistry.chemical_element ,Urine ,engineering.material ,Neuropsychological Tests ,Dental Amalgam ,stomatognathic system ,Medicine ,Humans ,Fine motor ,business.industry ,Confounding ,Public Health, Environmental and Occupational Health ,Mercury ,Middle Aged ,Dental amalgams ,Mercury (element) ,Amalgam (dentistry) ,Motor Skills Disorders ,stomatognathic diseases ,Cross-Sectional Studies ,chemistry ,Dental examination ,engineering ,Female ,business ,Cognition Disorders ,Research Article - Abstract
There is widespread concern regarding the safety of silver-mercury amalgam dental restorations, yet little evidence to support their harm or safety. We examined whether mercury dental amalgams are adversely associated with cognitive functioning in a cross-sectional sample of healthy working adults. We studied 550 adults, 30-49 years of age, who were not occupationally exposed to mercury. Participants were representative of employees at a major urban medical center. Each participant underwent a neuropsychologic test battery, a structured questionnaire, a modified dental examination, and collection of blood and urine samples. Mercury exposure was assessed using a) urinary mercury concentration (UHg); b) the total number of amalgam surfaces; and c) the number of occlusal amalgam surfaces. Linear regression analysis was used to estimate associations between each marker of mercury exposure and each neuropsychologic test, adjusting for potential confounding variables. Exposure levels were relatively low. The mean UHg was 1.7 micro g/g creatinine (range, 0.09-17.8); the mean total number of amalgam surfaces was 10.6 (range, 0-46) and the mean number of occlusal amalgam surfaces was 6.1 (range, 0-19). No measure of exposure was significantly associated with the scores on any neuropsychologic test in analyses that adjusted for the sampling design and other covariates. In a sample of healthy working adults, mercury exposure derived from dental amalgam restorations was not associated with any detectable deficits in cognitive or fine motor functioning.
- Published
- 2003
12. Perchlorate, Thiocyanate, Nitrate and Childhood Growth
- Author
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Liza Valentin-Blasini, Susan M. Pinney, Mary S. Wolff, Susan L. Teitelbaum, Ben Blount, Gayle C. Windham, Nancy Mervish, Ashley Pajak, Frank M. Biro, and Lawrence H. Kushi
- Subjects
chemistry.chemical_compound ,Perchlorate ,Nitrate ,chemistry ,Childhood growth ,Thiocyanate ,General Earth and Planetary Sciences ,General Environmental Science ,Nuclear chemistry - Published
- 2014
13. Dietary Predictors of Urinary Environmental Biomarkers in young girls, BCERP, 2004–7
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Gayle C. Windham, Frank M. Biro, Susan L. Teitelbaum, Xiaoyun Ye, Lawrence H. Kushi, Nancy Mervish, Manori J. Silva, Kathleen McGovern, Antonia M. Calafat, Mary S. Wolff, and Susan M. Pinney
- Subjects
endocrine system ,medicine.medical_specialty ,Urinary system ,Phthalic Acids ,Parabens ,Breast Neoplasms ,Biochemistry ,Article ,chemistry.chemical_compound ,Phenols ,Environmental health ,Internal medicine ,medicine ,Humans ,Benzhydryl compounds ,Benzhydryl Compounds ,Child ,General Environmental Science ,urogenital system ,business.industry ,digestive, oral, and skin physiology ,Food Packaging ,Environmental exposure ,Environmental Exposure ,Diet ,Endocrinology ,chemistry ,Environmental Biomarkers ,Food Preservatives ,Environmental Pollutants ,Female ,business ,hormones, hormone substitutes, and hormone antagonists ,Biomarkers ,Forecasting - Abstract
Exposures of children to phthalates, parabens, and bisphenol-A (BPA) are of concern because of their hormonal potential. These agents are found in a wide range of foods and packaging. We investigated whether intake of certain foods predict exposures to these chemicals in young girls.Among 1101 girls (6-8 years at enrollment) from the Breast Cancer and Environment Research Program (BCERP) study, we measured urinary exposure biomarkers for phthalates, parabens, and BPA and assessed dietary intake using 24-h recall 2-4 times. We examined the average daily servings of major and minor food groups categorized as 0 to0.5, 0.5 to1 and ≥ 1 servings per day. Items included dairy, eggs, fats, fish, fruit, single grains, meat, non-poultry meats, pasta, poultry and vegetables. Covariate-adjusted least squares geometric means and 95% confidence intervals of creatinine-corrected phthalate and phenol metabolite concentrations in urine were calculated in relation to food intake.Grains, flour and dry mixes and total fish consumption were positively associated with BPA and the sum of four di-2-ethylhexylphthalate (DEHP) urinary metabolite concentrations. Non-fresh vegetables and poultry were both positively associated with BPA and paraben urinary concentrations. Fats, oils and poultry consumption were positively associated with BPA. Whole-fat dairy consumption was associated with ΣDEHP.Some foods may contribute to child exposures to certain chemicals, and this may constitute modifiable means to reduce these environmental exposures.
- Published
- 2014
14. Dietary flavonol intake is associated with age of puberty in a longitudinal cohort of girls
- Author
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Susan L. Teitelbaum, Maida P. Galvez, Nancy Mervish, Michael E. Rybak, Eliza W. Gardiner, Lawrence H. Kushi, Frank M. Biro, Gayle C. Windham, Susan M. Pinney, and Mary S. Wolff
- Subjects
Longitudinal study ,medicine.medical_specialty ,Flavonols ,Endocrinology, Diabetes and Metabolism ,Phytoestrogens ,Article ,Lignans ,chemistry.chemical_compound ,Endocrinology ,Breast cancer ,Enterolactone ,4-Butyrolactone ,Internal medicine ,medicine ,Humans ,Breast ,Longitudinal Studies ,Child ,Lignan ,Breast development ,Nutrition and Dietetics ,business.industry ,Plant Extracts ,Hazard ratio ,Puberty ,Age Factors ,medicine.disease ,Pubic hair ,Diet ,medicine.anatomical_structure ,chemistry ,Female ,business ,Biomarkers ,Hair - Abstract
Lignans and flavonols are dietary phytoestrogens found at high concentrations in the Western Diet. They have potential to influence the timing of puberty. We hypothesized that greater consumption of these 2 phytoestrogens would be related to later age at pubertal onset among girls. Pubertal assessment and 24-hour diet recall data were available for 1178 girls, ages 6 to 8 years (mean 7.3 years) in the Breast Cancer and Environment Research Project Puberty Study. Lignan and flavonol intakes were mainly derived from fruit and vegetable consumption. Average consumption was 6.5 mg/d for flavonols and 0.6 mg/d for lignans. Highest flavonol consumption (>5 mg/d) was associated with later breast development (adjusted hazards ratio [HR]: 0.74, 95% CI: [0.61-0.91]) compared to 2 to 5 mg/d (adjusted HR: 0.84, 95% CI: [0.70-1.0]) and
- Published
- 2013
15. Temporal variability in urinary concentrations of perchlorate, nitrate, thiocyanate and iodide among children
- Author
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Ben Blount, Nancy Mervish, Susan L. Teitelbaum, Barbara Brenner, Maida P. Galvez, Liza Valentin-Blasini, and Mary S. Wolff
- Subjects
Time Factors ,Correlation coefficient ,Epidemiology ,Intraclass correlation ,Physiology ,Urine ,Toxicology ,Article ,chemistry.chemical_compound ,Perchlorate ,Nitrate ,Humans ,Child ,Reproducibility ,Nitrates ,Perchlorates ,Thiocyanate ,Public Health, Environmental and Occupational Health ,Reproducibility of Results ,Environmental Exposure ,Hispanic or Latino ,Iodides ,Chromatography, Ion Exchange ,Pollution ,Health Surveys ,Black or African American ,chemistry ,Environmental chemistry ,Biomarker (medicine) ,New York City ,Biomarkers ,Thiocyanates - Abstract
Perchlorate, nitrate and thiocyanate are ubiquitous in the environment, and human exposure to these chemicals is accurately measured in urine. Biomarkers of these chemicals represent a person's recent exposure, however, little is known on the temporal variability of the use of a single measurement of these biomarkers. Healthy Hispanic and Black children (6–10-year-old) donated urine samples over 6 months. To assess temporal variability, we used three statistical methods (n = 29; 153 urine samples): intraclass correlation coefficient (ICC), Spearman's correlation coefficient between concentrations measured at different timepoints and surrogate category analysis to assess how well tertile ranking by a single biomarker measurement represented the average concentration over 6 months. The ICC measure of reproducibility was poor (0.10–0.12) for perchlorate, nitrate and iodide; and fair for thiocyanate (0.36). The correlations for each biomarker across multiple sampling times ranged from 0.01–0.57. Surrogate analysis showed consistent results for almost every surrogate tertile. Results demonstrate fair temporal reliability in the spot urine concentrations of the three NIS inhibitors and iodide. Surrogate analysis show that single-spot urine samples reliably categorize participant's exposure providing support for the use of a single sample as an exposure measure in epidemiological studies that use relative ranking of exposure.
- Published
- 2011
16. Varicella-zoster virus infection in children with underlying human immunodeficiency virus infection
- Author
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David S. Hodes, Vincent R. Bonagura, Shaw Hwa Lo, Anne A. Gershon, Philip LaRussa, Sharon Steinberg, Nancy Mervish, Senih Fikrig, and Saroj Bakshi
- Subjects
Male ,Herpesvirus 3, Human ,Varicella vaccine ,viruses ,New York ,HIV Infections ,CD8-Positive T-Lymphocytes ,medicine.disease_cause ,Antibodies, Viral ,Herpes Zoster ,Virus ,Herpesviridae ,Chickenpox Vaccine ,Chickenpox ,medicine ,Immunology and Allergy ,Humans ,Prospective Studies ,Child ,integumentary system ,business.industry ,Varicella zoster virus ,virus diseases ,biochemical phenomena, metabolism, and nutrition ,medicine.disease ,Virology ,CD4 Lymphocyte Count ,Infectious Diseases ,Immunization ,Case-Control Studies ,Child, Preschool ,Immunology ,Disease Progression ,Female ,Viral disease ,business - Abstract
This article describes a prospective longitudinal study of varicella-zoster virus (VZV) infections in human immunodeficiency virus (HIV) ‐ infected children, designed to determine their natural history of VZV infection and possible effects of VZV on the progression of HIV infection. Varicella was usually not a serious acute problem, and it did not seem to precede clinical deterioration. The rate of zoster was high: 70% in children with low levels of CD4 / lymphocytes at the time of development of varicella. It is predicted that immunization with live attenuated varicella vaccine is unlikely to be deleterious to HIV-infected children. Moreover, if they are immunized when they still have relatively normal levels of CD4 / lymphocytes, they may have a lower rate of reactivation of VZV than if they were allowed to develop natural varicella when their CD4 / cell counts have fallen to low levels as a result of progressive HIV infection.
- Published
- 1997
17. The protective effect of immunologic boosting against zoster: an analysis in leukemic children who were vaccinated against chickenpox
- Author
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Shaw Hwa Lo, Paul Meier, Anne A. Gershon, Philip LaRussa, Sharon Steinberg, and Nancy Mervish
- Subjects
Herpesvirus 3, Human ,Varicella vaccine ,viruses ,Immunization, Secondary ,medicine.disease_cause ,Herpes Zoster ,Herpesviridae ,Virus ,Chickenpox ,Immunology and Allergy ,Medicine ,Humans ,Child ,Chickenpox Vaccine ,Proportional Hazards Models ,integumentary system ,business.industry ,Viral Vaccine ,Incidence ,Vaccination ,Varicella zoster virus ,virus diseases ,Viral Vaccines ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,medicine.disease ,Virology ,Infectious Diseases ,Child, Preschool ,Immunology ,business - Abstract
Whether reexposure of varicella-immune persons to varicella-zoster virus would protect against or predispose to development of zoster was analyzed. The rate of zoster in 511 leukemic recipients of varicella vaccine who had 1 or1 dose of varicella vaccine and in those who did or did not have a household exposure to varicella was determined. A Kaplan-Meier life-table analysis revealed that the incidence of zoster was lower in those given1 dose of vaccine (P.05). A Cox proportional hazards analysis showed that both household exposure to varicella and receipt of1 dose of vaccine were highly protective (P.01) against zoster. Thus, the risk of zoster is decreased by reexposure to varicella-zoster virus, either by vaccination or by close exposure to varicella.
- Published
- 1996
18. P-048
- Author
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Jessica Montana, Nancy Mervish, Andrea Rothenberg, Susan L. Teitelbaum, Mary S. Wolff, Barbara Brenner, and Maida P. Galvez
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Pediatrics ,medicine.medical_specialty ,Personal care ,Epidemiology ,Family medicine ,media_common.quotation_subject ,medicine ,Psychology ,Agreement ,media_common - Published
- 2012
19. P-219
- Author
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Mary S. Wolff, Antonia M. Calafat, Lawrence H. Kushi, Xiaoyun Ye, Frank M. Biro, Susan L. Teitelbaum, Gayle C. Windham, Kathleen McGovern, Nancy Mervish, Susan M. Pinney, and Manori J. Silva
- Subjects
medicine.medical_specialty ,Epidemiology ,business.industry ,Internal medicine ,medicine ,business ,Urinary biomarkers ,Gastroenterology - Published
- 2012
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