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The prevalence of fragility sacral fractures has been increasing with the rise in the number of osteoporotic patients and the development of diagnostic imaging. Sacral fracture can cause injury to the fifth lumbar (L5) nerve, although the incidence is low. The therapeutic strategy for sacral fracture with neurological injury has not yet been established, and the surgical strategy for fragility sacral fracture is more controversial. We describe a new therapeutic method using endoscopic surgery for L5 nerve root involvement caused by far-lateral lumbar disc herniation triggered by a fragility sacral fracture. A 55-year-old woman presented with right buttock and right lower limb pain without signs of trauma. Neurological examination revealed paresis of the right lower limb and hypoesthesia in the region innervated by the right L5 nerve root. Neuroimaging demonstrated a U-shaped sacral fracture, including the sacral ala, and right L5 extra-foraminal stenosis. The L5 nerve root was located near the vertical fracture, and compressed by far-lateral L5/S1 disc herniation. Full-endoscopic spine surgery (FESS) was performed to partially remove the right S1 superior articular process and to resect the degenerated disc material. L5 radiculopathy improved partially after the surgery. We suggest that FESS is an effective and safe therapeutic method for fragility sacral fractures associated with far-lateral lumbar disc herniation.