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Resource allocation under massive connectivity is one of the most important research topics due to widespread Internet-of-Things and machine-to-machine communication. Since multiple systems share the same frequency band due to the scarcity of frequency spectrum, resource allocation that takes into account the intersystem interference is essential. In this letter, an interference detection scheme that detects the change of the intersystem interference state is proposed. The proposed scheme is based on density ratio estimation using the available information at the resource controller. For change detection, the controller generates standard samples and test samples. Estimating the density ratio between test and standard samples enables the controller to detect change of the intersystem interference state. Under long-range wide area networks and a wireless-sensor utility network coexisting environment, the numerical results elucidate that the proposed scheme can improve average packet delivery rate by 10% compared to the system without interference detection.

With the progress of internet of things (IoT), devices with a wireless ad-hoc function are being increasingly used. For future wireless communication systems, the use of millimeter waves, which are strongly affected by shadowing, is considered. We focus on energy-efficiency [bits/J] that combines throughput and energy consumption, which is expected to be important in future wireless communication systems, to realize smart IoT in a shadowing environment. In this paper, we compare the effects of two parameters, including shadowing deviation values, on energy-efficiency in three dimensions for both AODV and OLSR protocols in a shadowing environment using network simulator, ns3.

With the further development of the internet-of-things (IoT), numerous nodes are expected to be densely deployed. If multiple nodes simultaneously transmit packets on the same frequency channel, packet collision can occur at the gateway leading to packet loss. By transmitting an acknowledgment (ACK) signal to the node whose packet was correctly received by the gateway, the other nodes can initiate packet retransmission in order to resolve packet loss. However, ACK signal transmission is required from the gateway to all the nodes, increasing the gateway processing load and impacting the duty cycle (DC) restriction on the gateway. In this paper, we propose an autonomous decentralized frequency resource allocation scheme for LoRaWAN, aiming to reduce the number of packet collisions and the gateway processing load. We implement the proposed approach, and demonstrate its effectiveness through computer simulation and experimental evaluation.

Due to the wide spread of machine-to-machine (M2M) communications and Internet-of-things (IoT), large number of wireless terminals are densely deployed. Under such dense deployment, it is necessary to manage the mutual interference among wireless terminals. Carrier-sense multiple access/collision avoidance (CSMA/CA) is one of the random access schemes that allow wireless terminals to access a channel while avoiding such mutual interference. However, if two wireless terminals are in the hidden terminal relation, a packet collision may happen as the carrier sense mechanism does not work. This results in the degradation of packet delivery rate (PDR) performance. Whether or not particular two wireless terminals are in the hidden terminal relation is an unobservable information from a network controller such as an access point (AP). In this paper, we tackle this problem by using machine learning. By using machine learning, the wireless controller makes a guess of the unobservable information from the observable information. We will use the wireless terminal locations and received signal strength at APs as the observable information. Based on the estimated unobservable information, the wireless controller assigns orthogonal resources to the wireless terminals that are in the relationship of hidden terminal in order to avoid the packet collision. Numerical results confirm that the proposed approach can improve the PDR performance up to 15% compared to the random resource allocation scheme.

A low power wide area network (LPWAN) is one of the promising technologies intended for Internet of Things (IoT). The LPWAN features a wide communication area that is a few kilometers to a few tens of kilometers; low power consumption is achieved using a battery. This study measures the transmission characteristics of a LoRaWAN which is one of the LPWAN. Therefore this paper shows the measured results in field experiment of certain cases: a road along the Tamagawa river in Tokyo, inside and around campuses, and a medium city environment. These measured results indicate that it is difficult to accurately perform a carrier sensing for LoRaWAN. Subsequently, we propose a method to realize the accurate spectrum sensing for spectrum sharing considering sensing sensitivity.

As means of the reduction of the environmental load, the change of the materials of the product is thought about. In order to grasp the load quantitatively, life cycle assessment is performed.In this report, the matter that we should pay attention to about environmental load of the materials of the railway is explained. In addition, as examples of evaluation of CO2 reduction effect, geo-polymer concrete production and the maintenance reduction effect resulting from the use of carbon contact strips on pantograph head are shown.

The superconducting magnetically levitated transportation (Maglev) system requires ground coils suitable for long-term outdoor use along the entire length of the guideway, meaning that the assurance of stable performance and high reliability is an important consideration in developing these coils. Durability verification testing from the level of the component materials to the actual product on the assumption of commercial service is therefore necessary to guarantee total reliability. We performed flexural fatigue tests using specimens made of the epoxy resin used for actual propulsion coils. The results were used to create a fatigue limit diagram as well as a diagram to verify Miner's Law. We then confirmed the correlation between the color difference and the flexural strength by comparing the outdoor exposure test results with those of accelerated artificial exposure testing.

Intermodalism has become one of the most important ways of transporting freight with the development of social economy and industry. In order to correspond to the changing nature of freight transport and to improve railway transport effectively, it is essential to upgrade conventional freight stations to provide sophisticated facilities where loading/ unloading services are directly handled on siding tracks for arrival and departure. In this paper, we discuss the improvements of railway freight stations based on advantage analysis by comparing the conventional type with the new one. We then cover the development of a mode-share model using stochastic distribution of freight time value. Next, we estimate the modal shift of freight resulting from improvements to station facilities, and finally we investigate the related environmental effects such as reduction in CO2 emissions.

This paper describes the environmental burden associated with various transportation modalities in Japan between 1985 and 2000 by employing an input-output type analysis. Measured greenhouse gases in the study included carbon dioxide, sulfur oxide, and nitrogen oxide. The modalities assessed that produced these gases were road traffic, aviation, railways, and coastal vehicles. It was found that, in the given time frame, the amount of such gases released from the railway modality was lower per unit than that of other modalities. Analysis of infrastructure burden took into account both construction and maintenance. For vehicular analysis, researchers considered both production and maintenance and, to determine the burden from operational energy, researchers analyzed both supply as well as consumption.

MAGLEV coils are moulded in resins such as epoxy and sheet moulding compounds. But the durability of resins is not yet sufficiently known well enough. Moreover, the mechanical strength of their moulding resin is degraded by the alkaline content in the concrete component of the guideway to which propulsion coils are attached. We performed bending fatigue tests using test pieces compliant pursuant to ASTM, and examined the flexural properties of test pieces immersed in an alkaline solution.

Bile salts can be cytotoxic to mucosal surfaces, because of their detergent properties. This is not normally seen under physiological circumstances in the gall-bladder. To further study normal mucosal defence mechanisms, the present study was performed to examine the effects of liposomes and hydrophilic bile salts on hydrophobic bile salt-induced release of radiolabelled glycoproteins from explants of guinea-pig gall-bladder. Glycoprotein release was correlated with the degree of hydrophobicity of bile salts, as determined by the retention factor in reversed-phase high-performance liquid chromatography. Hydrophobic bile salt-induced release of glycoproteins was reduced by liposomes and hydrophilic bile salts. The inhibitory effect of liposomes was directly related to the degree of saturation of their fatty acyl chains, and that of hydrophilic bile salts was related to the degree of hydrophilicity. These findings suggest that vesicles and hydrophilic bile salts may play a cytoprotective role against membrane damage passively caused by hydrophobic bile salts in the biliary system, and that such damage may occur according to the quantitative and qualitative imbalance among these factors.

To clarify factors involved in the formation of cholesterol gallstones, we studied the relationship between the degree of fatty acyl chain unsaturation of biliary lecithin and bile metastability. We used supersaturated model bile solutions (molar taurocholate/lecithin/cholesterol ratio (73:19.5:7.5), total lipid concentration 9 g/dl) that contained equimolar egg yolk or soybean lecithins or a sn-1 palmitoyl, sn-2 linoleoyl phosphatidylcholine. Gel permeation chromatographic studies showed that the vesicular cholesterol distribution and dimension were inversely related to the degree of unsaturation of the lecithin species, estimated by reverse phase, high-performance liquid chromatography. Differential interference contrast microscopy and assay of cholesterol crystal growth showed that a higher degree of fatty acyl chain unsaturation of the lecithin species was associated with a faster nucleation time and rate of crystal growth. Our results suggest that vesicular lecithins containing more unsaturated fatty acyl chains bind less tightly to cholesterol than lecithins containing predominantly saturated fatty acids, and that the biliary lecithin species dictates, in part, the nucleation and growth of cholesterol crystals in bile.

Simultaneous determination of biliary lipids was performed by alkaline hydrolysis, the formation of the methyl ester derivatives of fatty acids that are constituents of phospholipids and of the acetylated methyl ester derivatives of bile acids, and subsequent analysis by capillary column gas chromatography. Complete separation and satisfactory recovery of cholesterol, bile acids, and fatty acids were achieved. Also, the accuracy of the calculation of the bile cholesterol saturation index was enhanced by computation. Since the degree of acyl chain unsaturation affects the cholesterol-holding capacity in vesicles, this method provides a unique insight into bile metastability by the quantitative assessment of fatty acids in lecithin.

コレステロール過飽和人工胆汁を用いて,アポ蛋白A1のコレステロール結晶析出抑制の作用機序を検討した.アポ蛋白A1を添加した人工胆汁(A1+群)と無添加人工胆汁(A1-群)の脂質粒子をカラムクロマトグラフィー法にて分画採取し,両群の脂質粒子の形態変化を透過型電子顕微鏡にて経時的に比較検討した.両群において胆汁中脂質粒子は,ミセル分画と非ミセル分画に分離でき,A1+群においてアポ蛋白A1は,ミセル分画のピークよりわずかに高分子量領域にピークを有して溶出された.A1+, A1-両群において,同分画を透過型電子顕微鏡で観察すると,直径200～400Åのdisc様粒子が認められ,A1-群では,粒子の迅速な凝集と融合が観察されたのに対し,A1+群では,その変化は極めて緩徐であった.以上,コレステロール過飽和人工胆汁において,アポ蛋白A1のdisc様粒子安定化による,コレステロール結晶析出の抑制が示唆された.

We tested the possibility that pravastatin, a competitive inhibitor of hepatic hydroxymethyl glutaryl coenzyme A (HMG CoA) reductase, would alter cholesterol saturation of gallbladder bile by decreasing its cholesterol saturation index and/or degree of fatty acyl chain unsaturation in lecithin. Eighteen patients with type IIa hyperlipoproteinemia were treated with pravastatin 10 mg/d for 12 months. Gallbladder bile samples were aspirated with a duodenal tube by stimulating gallbladder contraction with intramuscular administration of cerulein before and after treatment. Serum cholesterol level was significantly reduced by 20% after 3 months, and this level was maintained after 12 months. In contrast, the cholesterol saturation index of gallbladder bile was not altered after 3 months (1.52 +/- 0.20 v 1.70 +/- 0.24), but it decreased significantly after 12 months (0.95 +/- 0.11, P.01). The degree of fatty acyl chain unsaturation tended to decrease, although this was not statistically significant except for the decrease in molar percent of linoleate after 3 months. These findings suggest that long-term treatment with an inhibitor of HMG CoA reductase improves bile lithogenicity even at a comparatively low dose, and can decrease the incidence and complications of cholesterol gallstones.

The effect of a concomitant infusion of organic anions, structurally related phthaleins, on bile flow was studied in anaesthetized dogs. A combination of rose bengal and sulfobromophthalein was found to uniquely and synergistically produce an acute, reversible form of intrahepatic cholestasis (< 10% of control level). This phenomenon was not observed with the administration of those individual organic anions at concentrations previously associated with the induction of intrahepatic cholestasis. The infusion of either a micelle forming bile salt, sodium taurocholate, or a non-micelle forming bile salt, sodium dehydrocholate, rapidly reversed the intrahepatic cholestasis (within 20 min after bile salt infusion). During the choleretic phase immediately following the bile salt infusion, a transient but marked hypersecretion, a disproportionately increased output in relation to that of bile acids, of biliary phospholipid (176% of control level by taurocholate and 138% of control level by dehydrocholate), and an even more striking amount of biliary protein hypersecretion were observed (392% of control level by taurocholate and 357% of control leverl by dehydrocholate). Although the significance of these new post-cholestatic observations requires clarification, it is suggested that the intrahepatic cholestasis induced by organic anions reflects a reversible defect in the mechanism(s) involved in transcellular transport.

This study was performed to explore the mechanisms by which sulphobromophthalein (BSP) reduces the secretion of biliary lipid using Sprague-Dawley rats (SDR) and mutant rats with congenital conjugated hyperbilirubinaemia bred from SDR (EHBR). We infused the bile-salt-pool-depleted rats with sodium taurocholate at a constant rate of 160 nmol/min per 100 g body wt. with BSP (12.5, 25 and 50 nmol/min per 100 g body wt.) or BSP-GSH (12.5, 25 and 50 nmol/min per 100 g body wt.). The biliary secretion of BSP and BSP-GSH was markedly impaired in EHBR as compared with that in SDR. BSP reduced the biliary secretion of cholesterol and phospholipids in a dose-dependent manner without affecting the secretion of bile salts and composition of fatty acids in phospholipids in SDR, but had no effect on lipid secretion in EHBR. In contrast, BSP-GSH had no such effect on biliary lipids, either in the SDR or EHBR. In addition, the amount of BSP in the liver of EHBR was in the same range as that of SDR. Therefore it is unlikely that an intracellular mechanism is involved in the phenomenon of uncoupling by BSP. We conclude that the uncoupling of biliary lipids from bile-salt secretion by BSP occurs at the level of the bile canaliculus following the secretion of unconjugated BSP.

The effects of pravastatin on cholesterol gallstone formation were determined in prairie dogs. We fed 10 prairie dogs 1% cholesterol with or without 0.05% (w/w) pravastatin (n = 5, each) for 4 weeks. In addition, another 5 prairie dogs were fed a standard rodent chow as a control. Only the animals fed 1% cholesterol without pravastatin treatment formed cholesterol gallstones. Gallbladder bile from cholesterol-fed animals contained cholesterol monohydrate crystals, whereas those treated with pravastatin contained no crystal. Furthermore, marked increases in tissue cholesterol levels (serum, liver and bile), and in biliary mucous glycoprotein levels were evident in cholesterol-fed animals, whereas pravastatin treatment normalized these levels. These findings raise the possibility that such inhibitors might have a future role to play in the prevention of cholesterol gallstone formation and/or recurrence.