1. Teratomas of the cranial vault: a systematic analysis of clinical outcomes stratified by histopathological subtypes
- Author
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Carlito Lagman, Mark Robert Libowitz, Courtney Duong, Lawrance K. Chung, Daniel T. Nagasawa, Naomi E. Walker, Timothy T. Bui, David J. Seo, Brittany L. Voth, and Isaac Yang
- Subjects
Male ,endocrine system ,medicine.medical_specialty ,endocrine system diseases ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Cranial vault ,medicine ,Adjuvant therapy ,Humans ,neoplasms ,Neuroradiology ,Univariate analysis ,medicine.diagnostic_test ,business.industry ,Brain Neoplasms ,Teratoma ,Magnetic resonance imaging ,medicine.disease ,Surgery ,030220 oncology & carcinogenesis ,Histopathology ,Female ,Neurology (clinical) ,Neurosurgery ,business ,030217 neurology & neurosurgery - Abstract
Teratomas of the cranial vault are divided into histopathological subtypes and grouped by prognoses: mature (good prognosis), mixed/malignant and immature teratomas (intermediate prognosis). This schema also includes non-teratomatous tumors. The authors of this study sought to elucidate histologically dependent predictors of survival and further clarify the classification system of intracranial teratomas. We performed a systematic analysis of the published literature to identify studies describing patients with intracranial teratomas diagnosed with magnetic resonance imaging (MRI) and presenting definite information on histologies, therapies, and outcomes at a minimum follow-up of 2 years. Disease-free (DFS) and overall survival (OS) were evaluated. A total of 18 articles comprised of 134 patients were included. On univariate analysis, male sex and gross-total resection (GTR) were associated with high mean DFS (p = 0.0362 and p
- Published
- 2016