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473 results on '"Narciso, Pasquale"'

3. Study of Genotypic and Phenotypic HIV-1 Dynamics of Integrase Mutations During Raltegravir Treatment: A Refined Analysis by Ultra-Deep 454 Pyrosequencing

Author

Armenia, Daniele, Vandenbroucke, Ina, Fabeni, Lavinia, Van Marck, Herwig, Cento, Valeria, D'Arrigo, Roberta, Van Wesenbeeck, Liesbeth, Scopelliti, Fernanda, Micheli, Valeria, Bruzzone, Bianca, Caputo, Sergio Lo, Aerssens, Jeroen, Rizzardini, Giuliano, Tozzi, Valerio, Narciso, Pasquale, Antinori, Andrea, Stuyver, Lieven, Perno, Carlo Federico, and Ceccherini-Silberstein, Francesca

Published
2012
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5. Specific Enfuvirtide-Associated Mutational Pathways in HIV-1 Gp41 Are Significantly Correlated with an Increase in CD4⁺ Cell Count, despite Virological Failure

Author

Svicher, Valentina, Aquaro, Stefano, D'Arrigo, Roberta, Artese, Anna, Dimonte, Salvatore, Alcaro, Stefano, Santoro, Maria Mercedes, Di Perri, Giovanni, Lo Caputo, Sergio, Bellagamba, Rita, Zaccarelli, Mauro, Visco-Comandini, Ubaldo, Antinori, Andrea, Narciso, Pasquale, Ceccherini-Silberstein, Francesca, and Perno, Carlo-Federico

Published
2008
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7. A Comparison between Abacavir and Efavirenz as the Third Drug Used in Combination with a Background Therapy Regimen of 2 Nucleoside Reverse-Transcriptase Inhibitors in Patients with Initially Suppressed Viral Loads

Author

ICoNA Study Group, UCSC-Roma HIV Cohort Study Group, IMIT Study Group, Cozzi-Lepri, Alessandro, De Luca, Andrea, Phillips, Andrew N., Bongiovanni, Marco, Di Giambenedetto, Simona, Mena, Maurizio, Moioli, Maria Cristina, Arlotti, Massimo, Sighinolfi, Laura, Narciso, Pasquale, Lichtner, Miriam, Cauda, Roberto, and Monforte, Antonella d'Arminio

Published
2006

8. Mutations in HIV-l Reverse Transcriptase Potentially Associated with Hypersusceptibility to Nonnucleoside Reverse-Transcriptase Inhibitors: Effect on Response to Efavirenz-Based Therapy in an Urban Observational Cohort

Author

Tozzi, Valerio, Zaccarelli, Mauro, Narciso, Pasquale, Trotta, Maria Paola, Ceccherini-Silberstein, Francesca, De Longis, Patrizio, D'Offizi, Giampiero, Forbici, Federica, D'Arrigo, Roberta, Boumis, Evangelo, Bellagamba, Rita, Bonfigli, Sandro, Carvelli, Chiarina, Antinori, Andrea, and Perno, Carlo Federico

Published
2004

15. Evaluating adherence to highly active antiretroviral therapy with use of pill counts and viral load measurement in the drug resources enhancement against AIDS and malnutrition program in Mozambique

Author

Magnano San Lio, Massimo, Carbini, Riccardo, Germano, Paola, Guidotti, Giovanni, Mancinelli, Sandro, Magid, Noorjehan Abdul, Narciso, Pasquale, Palombi, Leonardo, Renzi, Elsa, Zimba, Ines, and Marazzi, Maria Cristina

Subjects
Patient compliance -- Research, Highly active antiretroviral therapy -- Dosage and administration, AIDS (Disease) -- Care and treatment, Health, Health care industry
Published
2008

16. HIV-related pneumococcal lung disease: does highly active antiretroviral therapy or bacteremia modify radiologic appearance?

Author

Rizzi, Elisa Busi, Schinina, Vincenzo,Rovighi, Laura, Cristofaro, Massimo, Bordi, Eugenio, Narciso, Pasquale, and Bibbolino, Corrado

Subjects
HIV patients -- Physiological aspects, HIV patients -- Medical examination, Lung diseases -- Risk factors, Lung diseases -- Diagnosis, Lung diseases -- Care and treatment, Lung diseases -- Research, Highly active antiretroviral therapy -- Health aspects, Highly active antiretroviral therapy -- Research, Health
Abstract

We reviewed chest radiographs of 57 HIV-infected patients with pulmonary diseases in whom Streptococcus pneumoniae was the sole respiratory pathogen isolated to evaluate whether highly active antiretroviral therapy (HAART) or bacteremia modify radiographic appearance. Pneumococcal lung disease presented as lobar pneumonia in 40% of the cases, 54% of whom were on HAART; as bronchopneumonia in 42%, 58% on HAART; as interstitial infiltrates in 17%, 60% on HAART. Bacteremia was observed 38 times in 23 patients with CD4 less than 200/[mm.sup.3], and in 15 with CD4 greater than 200/[mm.sup.3] (p > 0.05). HAART does not significantly influences radiographic appearances of lung disease caused by Streptococcus pneumoniae (p > 0.05). Immunosuppression induced by HIV infection was a major risk factor for development of pneumococcal lung disease (p = 0.04) and influences radiographic appearance; bronchopneumonia (p = 0.006), in particular multifocal (p = 0.008), which was more frequent in subjects with CD4 less than 200/[mm.sup.3]. Bacteremia influences radiographic appearance of pneumococcal lung disease; lobar pneumonia was more frequent (p = 0.003), and considering CD4 cell count, was more frequent if CD4 cell count was above 200/[mm.sup.3]. An original finding of this study was the frequency of interstitial changes. This pattern of pneumonia, found in 17% of our patients, could represent a difference between HIV-seropositive and -seronegative subject in displaying pneumococcal lung disease.

Published
2008

17. Viro-immunologic response to ritonavir-boosted or unboosted atazanavir in a large cohort of multiply treated patients: the care study

Author

Santoro, Maria Mercedes, Bertoli, Ada, Lorenzini, Patrizia, Lazzarin, Adriano, Esposito, Roberto, Carosi, Giampiero, Di Perri, Giovanni, Filice, Gaetano, Moroni, Mauro, Rizzardini, Giuliano, Caramello, Pietro, Maserati, Renato, Narciso, Pasquale, Cargnel, Antonietta, Antinori, Andrea, and Perno, Carlo Federico

Subjects
Atazanavir -- Dosage and administration, Atazanavir -- Comparative analysis, HIV infection -- Drug therapy, HIV infection -- Comparative analysis, Health
Abstract

Currently, comparative data able to define the potency of boosted versus unboosted atazanavir in highly pretreated HIV-infected patients are limited. Specifically, in clinical practice it is very important to establish whether atazanavir-boosting with ritonavir warrants potency and efficacy that overcome the profile of unboosted drug. For this reason, our goal was to evaluate viro-immunologic determinants of response to atazanavir, in unboosted ATV400 or boosted ATV300/r formulation, from baseline to week 48 in highly pretreated HIV-infected patients enrolled in a prospective observational Italian study. Data from 354 patients included in an atazanavir 'Early Access Program' (AI424-900) with baseline viremia 500 copies per milliliter or more and with an available virologic follow-up were examined using as-treated analysis. Of these, 200 (56.5%) and 154 (43.5%), respectively, received regimens containing ATV300/r or ATV400. Virologic success (VS) was defined as reaching viremia of less than 500 copies per milliliter during follow-up. Estimated median rime to VS was 8 weeks in the ATV300/r group and 13 weeks in the ATV400 group. Proportion of patients achieving VS was higher in the ATV300/r group than in ATV400 group at week 12 (66% versus 47%), as well as at week 48 (86% versus 64%). At mulfivariate Cox regression, receiving ATV300/r dosing was independently associated with increased probability of achieving VS [adjusted hazard ratio (AHR): 1.57; 95% confidence interval (CI): 1.19-2.061. Conversely, CDC stage C, higher base line viral load, and more experience with protease inhibitors (PIs) were associated with poorer virologic response. In an unselected population of highly pretreated HIV-infected individuals, receiving atazanavir as part of antiretroviral regimen results in effective virologic response and immunologic recovery. The antiviral efficacy of atazanavir is greater when boosted with low-dose ritonavir.

Published
2008

18. Persistence of neuropsychologic deficits despite long-term highly active antiretroviral therapy in patients with HIV-related neurocognitive impairment

Author

Tozzi, Valerio, Balestra, Pietro, Bellagamba, Rita, Corpolongo, Angela, Salvatori, Maria Flora, Visco-Comandini, Ubaldo, Vlassi, Chrysoula, Giudianelli, Marinella, Galgani, Simonetta, Antinori, Andrea, and Narciso, Pasquale

Subjects
Highly active antiretroviral therapy -- Health aspects, HIV patients -- Psychological aspects, HIV patients -- Health aspects, Health
Abstract

The prevalence and predictors of persistent neuro psychologic (NP) deficits despite long-term highly active antiretroviral therapy (HAART) in patients with HIV-related neurocognitive impairment (NCI) are assessed. It is observed that 59 percent of the patients had persistent NP deficits.

Published
2007

19. Prevalence and risk factors for human immunodeficiency virus-associated neurocognitive impairment, 1996 to 2002: Results from an urban observational cohort

Author

Tozzi, Valerio, Balestra, Pietro, Lorenzini, Patrizia, Bellagamba, Rita, Galgani, Simonetta, Corpolongo, Angela, Vlassi, Chrysoula, Larussa, Dora, Zaccarelli, Mauro, Noto, Pasquale, Visco-Comandini, Ubaldo, Giulianelli, Marinella, Ippolito, Giuseppe, Antinori, Andrea, and Narciso, Pasquale

Published
2005
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20. Neuroactive antiretroviral drugs do not influence neurocognitive performance in less advanced HIV-infected patients responding to highly active antiretroviral therapy

Author

Giancola, Maria Letizia, Lorenzini, Patrizia, Balestra, Pietro, Larussa, Dora, Baldini, Francesco, Corpolongo, Angela, Narciso, Pasquale, Bellagamba, Rita, Tozzi, Valerio, and Antinori, Andrea

Subjects
HIV patients -- Care and treatment, HIV patients -- Health aspects, Highly active antiretroviral therapy -- Patient outcomes, Cerebrospinal fluid -- Health aspects, Health
Abstract

The effect of antiretroviral therapy, including drugs that have good penetration in cerebrospinal fluid (CSF), on neuropsychologic performance is analyzed. It was found that the use of stable highly active antiretroviral therapy including multiple drugs that have good CSF penetration, was not associated with neuropsychologic performance.

Published
2006

22. Highly active antiretroviral therapy restores CD4(super +) V beta T-cell repertoire in patients with primary acute HIV infection but not in treatment-naive HIV(super +) patients with severe chronic infection

Author

Cossarizza, Andrea, Poccia, Fabrizio, Agrati, Chiara, D'Offizi, Gianpiero, Bugarini, Roberto, Pinti, Marcello, Borghi, Vanni, Mussini, Cristina, Esposito, Roberto, Ippolito, Giuseppe, and Narciso, Pasquale

Subjects
HIV infection -- Research, CD4 lymphocytes -- Research, Highly active antiretroviral therapy -- Research, Highly active antiretroviral therapy -- Dosage and administration, Health
Abstract

The effects of highly active antiretroviral therapy on the reconstitution of the T-cell receptor repertoire in drug-naive HIV(super +) patients were analyzed. The results indicated that highly active antiretroviral therapy can restore the T-cell receptor repertoirein individuals whose immune system is not severely compromised by the infection.

Published
2004

29. Correlates and predictors of adherence to highly active antiretroviral therapy: overview of published literature

Author

Ammassari, Adriana, Trotta, Maria Paola, Murri, Rita, Castelli, Francesco, Narciso, Pasquale, Noto, Pasquale, Vecchiet, Jacopo, Monforte, Antonella d'Arminio, Wu, Albert W., and Antinori, Andrea

Subjects
Drug therapy -- Analysis, Epidemiology -- Statistics, Epidemiology -- Research, HIV patients -- Health aspects, HIV patients -- Care and treatment, HIV infection -- Prevention, HIV infection -- Research, HIV infection -- Health aspects, Antiviral agents -- Physiological aspects, AIDS (Disease) -- Research, Health
Abstract

The authors discuss the publications on the factors associated with medication adherence in HIV-infected patients. The topics of interest include the existing barriers to optimal highly active antiretroviral therapy which include adherence measurement and adherence correlates and predictors assessment.

Published
2002

32. Self-reported symptoms and medication side effects influence adherence to highly active antiretroviral therapy in persons with HIV infection

Author

Ammassari, Adriana, Murri, Rita, Pezzotti, Patrizio, Trotta, Maria Paola, Ravasio, Laura, Longis, Patrizio De, Caputo, Sergio Lo, Narciso, Pasquale, Pauluzzi, Sergio, Carosi, Giampiero, Nappa, Salvatore, Piano, Paola, Izzo, Crescenzo M., Lichtner, Miriam, Rezza, Giovanni, Monforte, Andonella d'Arminio, Ippolito, Giuseppe, Moroni, Mauro, Wu, Albert W., and Antinori, Andrea

Subjects
AIDS (Disease) -- Care and treatment, HIV infection -- Drug therapy, Highly active antiretroviral therapy -- Usage, Drugs -- Adverse and side effects, Patient compliance -- Research, Health
Abstract

Self-reported symptoms and medication side effects have been found to influence adherence to highly active antiretroviral therapy (HAART) in those with HIV infection. Of 358 persons enrolled in the study, 22% reported nonadherence in a study to identify variables predictive of nonadherence to HAART and to assess whether self-reported symptoms or medication side effects are related to adherence.

Published
2001

33. Changes in neurocognitive performance in a cohort of patients treated with HAART for 3 years

Author

Tozzi, Valerio, Balestra, Pietro, Galgani, Simonetta, Narciso, Pasquale, Sampaolesi, Alessandro, Antinori, Andrea, Giulianelli, Marinella, Serraino, Diego, and Ippolito, Giuseppe

Subjects
Epidemiology -- Statistics, Epidemiology -- Research, HIV patients -- Case studies, HIV patients -- Health aspects, HIV patients -- Care and treatment, HIV infection -- Prevention, HIV infection -- Research, HIV infection -- Health aspects, Highly active antiretroviral therapy -- Methods, Protease inhibitors -- Physiological aspects, AIDS dementia -- Care and treatment, AIDS dementia -- Health aspects, AIDS dementia -- Causes of, AIDS (Disease) -- Research, Health
Abstract

Research has been conducted on HIV-associated neurocognitive inpairment in patients treated with highly active antiretroviral therapy. The authors have investigated the changes in these patients after the treatment, and they have concluded that the ongoing HIV-related neurologic damage can occur even during the antiretroviral treatment.

Published
2001

34. ‘Sentinel’ mutations in standard population sequencing can predict the presence of HIV-1 reverse transcriptase major mutations detectable only by ultra-deep pyrosequencing

Author

Alteri, Claudia, Santoro, Maria Mercedes, Abbate, Isabella, Rozera, Gabriella, Bruselles, Alessandro, Bartolini, Barbara, Gori, Caterina, Forbici, Federica, Orchi, Nicoletta, Tozzi, Valerio, Palamara, Guido, Antinori, Andrea, Narciso, Pasquale, Girardi, Enrico, Svicher, Valentina, Ceccherini-Silberstein, Francesca, Capobianchi, Maria Rosaria, and Perno, Carlo Federico

Published
2011
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