31 results on '"Nario, K."'
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2. The effect of adenosine on cochlear potentials in the guinea pig
- Author
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Nario, K., Kitano, I., Mori, N., and Matsunaga, T.
- Published
- 1994
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3. Autoradiographic measurement of regional brainstem blood flow: occlusion of the anterior inferior cerebellar artery
- Author
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Inui, H., Miyahara, H., Nario, K., and Matsunaga, T.
- Published
- 1994
- Full Text
- View/download PDF
4. Edoxaban versus warfarin in patients with atrial fibrillation
- Author
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Robert P. Giugliano, Christian T. Ruff, Eugene Braunwald, Sabina A. Murphy, Stephen D. Wiviott, Jonathan L. Halperin, Albert L. Waldo, Michael D. Ezekowitz, Jeffrey I. Weitz, Jind?ich ?pinar, Witold Ruzyllo, Mikhail Ruda, Yukihiro Koretsune, Joshua Betcher, Minggao Shi, Laura T. Grip, Shirali P. Patel, Indravadan Patel, James J. Hanyok, Michele Mercuri, Elliott M. Antman, Braunwald E, Antman EM, Giugliano RP, Ruff CT, Morin SE, Hoffman EB, Murphy SA, Deenadayalu N, Grip L, Mercuri M, Lanz H, Patel I, Curt V, Duggal A, Hanyok J, Davé J, Morgan D, Choi Y, Shi M, Jin J, Xie J, Crerand W, Kappelhof J, Maxwell W, Skinner M, Patel S, Betcher J, Selicato G, Otto C. Jr, Reissner C, Smith K, Ostroske J, Ron A, Giugliano R, Connolly S, Camm J, Ezekowitz M, Halperin J, Waldo A, Paolasso E, Aylward P, Heidbuchel H, Nicolau JC, Goudev A, Roy D, Weitz J, Corbalán R, Yang Y, Botero R, Bergovec M, Ŝpinar J, Grande P, Hassager C, Voitk J, Huikuri H, Nieminen M, Blanc JJ, LeHeuzey JY, Mitrovic V, Alexopoulos D, Sotomora G, Kiss R, SomaRaju B, Lewis B, Merlini P, Metra M, Koretsune Y, Yamashita T, García Castillo A, Ophuis T, White H, Atar D, Horna M, Babilonia N, Ruzyllo W, Morais J, Dorobantu M, Ruda M, Ostojic M, Duris T, Dalby A, Chung N, Zamorano JL, Juul Möller S, Moccetti T, Chen SA, Sritara P, Oto A, Parkhomenko A, Senior R, Verheugt F, Skene A, Anderson J, Bauer K, Easton JD, Goto S, Wiviott S, Lowe C, Awtry E, Berger CJ, Croce K, Desai A, Gelfand E, Goessling W, Greenberger NJ, Ho C, Leeman DE, Link MS, Norden AD, Pande A, Rost N, Ruberg F, Silverman S, Singhal A, Vita JA, Vogelmann O, Gonzalez C, Ahuad Guerrero R, Rodriguez M, Albisu J, Rosales E, Allall O, Reguero M, Alvarez C, Garcia M, Ameriso S, Ameriso P, Amuchastegui M, Caceres M, Beloscar J, Petrucci J, Berli M, Budassi N, Valle M, Bustamante Labarta G, Saravia M, Caccavo A, Fracaro V, Cartasegna L, Novas V, Caruso O, Zarandon RS, Colombo H, Morandini M, Cuello J, Rosell M, Cuneo C, Bocanera M, D'Amico A, Cendali G, Dran R, Moreno V, Estol C, Davolos M, Facello A, Facello M, Falu E, Iriarte M, Femenia F, Arrieta M, Fuselli J, Zanotti A, Gant Lopez J, Meiller F, Garcia Duran R, Perlo D, Garrido M, Ceirano C, Giacomi G, Eden M, Giannaula R, Huerta M, Goicoechea R, von Wulffen M, Hominal M, Bianchini M, Jure H, Jure D, Kevorkian R, Monaco F, Lanternier G, Belcuore M, Liniado G, Iglesias M, Litvak B, Nigro A, Llanos J, Vignau S, Lorente C, Shatsky K, Lotti J, Raimondi G, Mackinnon I, Carne M, Manuale O, Calderon M, Marino J, Funes I, Muntaner J, Gandur H, Nul D, Verdini E, Piskorz D, Tommasi A, Povedano G, Casares E, Pozzer D, Fernandez E, Prado A, Venturini C, Ramos H, Navarrete S, Alvarez M, Sanchez A, Bowen L, Sanjurjo M, Codutti O, Saravia Toledo S, Formoso I, Schmidberg J, Goloboulicz A, Schygiel P, Buzzetti C, Severino P, Morara P, Sosa Liprandi M, Teves M, Vico M, Morell Y, Anderson C, Paraskevaidis T, Arstall M, Hoffmann B, Colquhoun D, Price Smith S, Crimmins D, Slattery A, Dart A, Kay S, Davis S, Silver G, Flecknoe Brown S, Roberts J, Gates P, Jones S, Lehman R, Morrison H, McKeirnan M, Li J, Paul V, Batta C, Purnell P, Perrett L, Szto G, O'Shea V, Capiau L, Banaeian F, De Bleecker J, de Koning K, De Tollenaere M, De Bruyne L, Desfontaines P, Tincani G, Meeusen K, Herzet J, Malmendier D, Mairesse G, Raepers M, Parqué J, Clinckemaille N, Scavée C, Huyberechts D, Stockman D, Jacobs C, Vandekerckhove Y, Derycker K, Vanwelden J, van Welden J, Vervoort G, Mestdagh I, Vrolix M, Beerts C, Wollaert B, Denie D, Amato Vincenzo de Paola A, Coutinho E, Andrade Lotufo P, de Melo RF, Atie J, Motta C, Augusto Alves da Costa F, Ferraz RF, Bertolim Precoma D, Sehnem E, Botelho R, Cunha S, Brondani R, Fleck N, Chaves Junior H, Silva J, Costantini C, Barroso D, De Patta M, Pereira V, Duda N, Laimer R, Dutra O, Morgado S, Faustino Saporito W, Seroqui M, Ferreira L, Araújo E, Finimundi H, Daitz C, Gagliardi R, Pereira G, Gomes M, Gomes A, Guimarães A, Ninho L, Jaeger C, Pereira L, Jorge J, Cury C, Kaiser S, Almeida A, Kalil C, Radaelli G, Kunz Sebba Barroso de Souza W, Morales K, Leaes P, Luiz RO, Pimenta Almeida J, Gozalo A, Reis G, Avellar K, Reis Katz Weiand L, Leipelt J, Rocha J, Barros R, Rodrigues L, Rocha MR, Rodrigues A, Rodrigues D, Rossi dos Santos F, Pagnan LG, Sampaio R, do Val R, Saraiva J, Vicente C, Simoes M, Carraro A, Sobral Filho D, Lustosa E, Villas Boas F, Almeida M, Zimmermann S, Zimmermann EB, Chompalova B, Parishev G, Denchev S, Milcheva N, Donova T, Gergova V, Georgiev B, Kostova E, Kinova E, Hergeldjieva V, Kamenova P, Manolova A, Vasilev I, Mihov A, Miteva B, Mincheva V, Stoyanovski V, Nikolov F, Vasilev D, Pencheva G, Kostov K, Petranov S, Milusheva T, Popov A, Staneva A, Momchilova Lozeva D, Todorov G, Nyagina M, Tumbev H, Tumbeva D, Tzekova M, Kitova M, Manoylov E, Archibald J, Antle S, Bhargava R, Stafford C, Bose S, Hundseth M, Cha J, Otis J, Chehayeb R, Lepage C, Chilvers M, Vansickle L, Cleveland D, Valley S, Constance C, Gauthier M, Costi P, Masson C, Coutu B, Denis I, du Preez M, Kubanska A, Dufresne M, Krider J, Eikelboom J, Zondag M, Fortin C, Viau C, Green M, Houbraken D, Hatheway R, Mabee J, Heath J, Scott L, Ho K, Ho V, Hoag G, Standring R, Huynh T, Perkins L, Kouz S, Roy M, Labonte R, Dewar C, Lainesse A, St Germain L, Lam S, Lam H, Lichtenstein T, Roberts P, Luton R, Douglas S, Ma P, Seib M, MacCallum C, Matthews J, Malette P, Vaillancourt T, Maranda C, Studenikow E, Mawji A, Morely A, Morrison D, Roth M, Mucha M, Najarali A, Lamoureux U, Nicholson R, O'Hara G, Banville P, O'Mahony W, Bolton R, Parkash R, Carroll L, Pesant Y, Sardin V, Polasek P, Turri L, Qureshi A, Nethercott C, Ricci J, Bozek B, Rupka D, Marchand C, Shu D, Silverio G, St Hilaire R, Morissette A, Sussman J, Kailey P, Syan G, Bobbie C, Talajic M, David D, Talbot P, Tremblay M, Teitelbaum I, Teitelbaum J, Velthuysen G, Giesbrecht L, Wahby R, Morley A, Wharton S, Caterini T, Woodford T, Balboa W, Matus LR, Bugueño C, Mondaca PM, Cobos J, Obreque C, Corbalan R, Parada A, Florenzano F, Diaz PA, Lopetegui M, Rebolledo C, Manriquez L, Silva LM, Martinez D, Llamas RR, Opazo M, Pérez MC, Pincetti C, Carrasco GT, Potthoff S, Staub JZ, Campisto Y, Stockins B, Lara CL, Yovaniniz P, Azua MG, Bai F, Xu GL, Chen JZ, Xie XD, Chen XP, Zhang X, Dong YG, Feng C, Fu GS, Zhang P, Hong K, You ZG, Hong L, Qiu Y, Jiang XJ, Qu Z, Li L, Liu H, Li TF, Kong YQ, Li WM, Liu B, Li ZQ, Liu Y, Liao DN, Gu XJ, Liu L, Lu ZH, Ma SM, Yang ZY, Wang DM, Qi SY, Wang GP, Shi XJ, Wei M, Huang D, Wu SL, Li YE, Xu JH, Gu JY, Xu YM, Liang YZ, Yang K, Li AY, Yang YJ, Zheng X, Zheng Y, Gao M, Yin YH, Xu YP, Yu B, Li LL, Yuan ZY, Qiang H, Zhang HQ, Lin YN, Zhang Z, Kang H, Zhao RP, Han RJ, Zhao XL, Wang JQ, Zheng ZQ, Li BG, Zhou SX, Zhang YL, Accini J, Accini M, Cano N, Pineda LL, Delgado Restrepo J, Arroyave C, Fernández Ruiz R, Diaz IA, Hernandez H, Delgado P, Jaramillo Muñoz C, Builes A, Manzur F, Rodriguez ER, Moncada Corredor M, Giraldo DL, Orozco Linares L, Fonseca J, Quintero A, Gonzales C, Sanchez Vallejo G, Mejia IP, Bagatin J, Carevic V, Car S, Jeric M, Ciglenecki N, Tusek S, Ferri Certic J, Romic I, Francetic I, Ausperger KM, Jelic V, Jurinjak SJ, Knezevic A, Buksa B, Samardzic P, Lukenda KC, Steiner R, Kirner D, Sutalo K, Bakliza Z, Vrazic H, Lucijanic T, Bar M, Brodova P, Berka L, Kunkelova V, Brtko M, Burianova H, Cermak O, Elbl L, Ferkl R, Florian J, Francek L, Golan L, Gregor P, Honkova M, Hubac J, Jandik J, Jarkovsky P, Jelinek Z, Jerabek O, Jirmar R, Kobza R, Kochrt M, Kostkova G, Kosek Z, Kovar P, Kuchar R, Kvasnicka J, Ludka O, Machova V, Krocova E, Melichar M, Nechanicky R, Olsr J, Peterka K, Petrova I, Havlova I, Pisova J, Podrazil P, Jirsova E, Reichert P, Slaby J, Spacek R, Spinar J, Labrova R, Vodnansky P, Samkova D, Zidkova E, Dodt K, Christensen H, Christensen L, Loof A, Ibsen H, Madsen H, Iversen H, Veng Olsen T, Nielsen H, Olsen R, Overgaard K, Petrovic V, Raymond I, Raae D, Sand N, Svenningsen A, Torp Pedersen C, Jakobsen U, Wiggers H, Serup Hansen K, Kaik J, Stern A, Kolk R, Laane E, Rivis L, Paumets M, Laheäär M, Rosenthal A, Rajasalu R, Vahula V, Ratnik E, Kaarleenkaski S, Hussi E, Valpas S, Jäkälä P, Lappalainen T, Mäenpää A, Viitaniemi J, Nyman K, Sankari T, Rasi H, Salminen O, Virtanen V, Nappila H, Le Heuzey J, Agraou B, El Jarroudi F, Amarenco P, Boursin P, Babuty D, Boyer M, Belhassane A, Berbari H, Blanc J, Dias P, Coisne D, Berger N, Decoulx E, El Jarroudi M, Dinanian S, Arfaoui M, Hermida J, Deruche E, Kacet S, Corbut S, Poulard J, Leparree S, Roudaut R, Duprat C, Al Zoebi A, Wurow A, Bernhardt P, Dichristin U, Berrouschot J, Vierbeck S, Beyer Westendorf J, Sehr B, Bouzo M, Schnelzer P, Braun R, Ladenburger K, Buhr M, Weihrauch D, Contzen C, Kara M, Daut W, Ayasse D, Degtyareva E, Kranz P, Drescher T, Herfurth B, Faghih M, Forck Boedeker K, Schneider K, Fuchs R, Manuela W, Grigat C, Otto A, Hartmann A, Peitz M, Heuer H, Dieckheuer U, Hoffmann U, Dorn S, Hoffmann S, Schuppe M, Horacek T, Fink P, Junggeburth J, Schmid S, Jungmair W, Schoen B, Kleinecke Pohl U, Meusel P, Koenig H, Bauch F, Lohrbaecher Kozak I, Grosse B, Lueders S, Venneklaas U, Luttermann M, Wulf M, Maus O, Hoefer K, Meissner G, Braemer U, Meyer Pannwitt U, Frahm E, Vogt S, Muegge A, Barbera S, Mueller Glamann M, Raddatz K, Piechatzek R, Lewinsky D, Pohl W, Proskynitopoulos N, Kuhlmann M, Rack K, Pilipenko H, Rinke A, Kühlenborg A, Schaefer A, Szymanowski N, Schellong S, Frommhold R, Schenkenberger I, Finsterbusch T, Dreykluft K, Schiewe C, Schmidt A, Schmidt M, Schreckenberg A, Hellmers J, Seibert H, Gold G, Sohn H, Baylacher M, Spitzer S, Bonin K, Stoehring R, Taggeselle J, Zarpentin C, Veltkamp R, Ludwig I, Voehringer, Buchholz M, Weyland K, Winkelmann B, Buelow Johansen B, Wolde C, Winter K, Mavronasiou E, Bourlios P, Tziortziotis A, Karamitsos C, Exarchou E, Kifnidis K, Daskalaki A, Moschos N, Dimitra K, Olympios C, Kartsagkoulis E, Pyrgakis V, Korantanis K, Ayau Milla O, Ramirez Vde L, Guzman Melgar I, Jimenez T, Ovando Lavagnino A, Guevara S, Rodas Estrada M, Sanchez M, Pozuelos JM, Sanchez Samayoa C, Guerra L, Velasquez Camas L, Almaraz SP, Dioszeghy P, Muskoczki E, Edes I, Szatmari J, Fiok J, Varga A, Kanakaridisz N, Kosztyu M, Kis E, Feil JF, Jakal A, Koczka M, Kovacs I, Baranyai M, Kovacs Z, Lupkovics G, Karakai HH, Matoltsy A, Kiss T, Medvegy M, Kiss K, Merkely B, Kolumban E, Nagy A, Palinkas A, Toth SR, Sayour A, Bognar A, Simor T, Ruzsa D, Sipos T, Szakal I, Tomcsanyi J, Marosi A, Vertes A, Kincses M, Malhan S, Abdullakutty J, Agarwal D, Ranka R, Arneja J, Memon A, Arora V, Shree R, Avvaru G, Shaikh A, Babu P, Rao B, Babu R, Reddy J, Banker D, Sheth T, Benjarge P, Surushe S, Bharani A, Solanki R, Bhargava V, Rathi A, Biniwale A, Bhuti M, Calambur N, Somaraju B, Karnwal N, Chopda M, Mali N, Goyal N, Saini A, Gupta J, Singh P, Hadan S, Savanth P, Hardas S, Thakor G, Hiremath J, Ghume A, Jain R, Pahuja M, Joseph S, Oommen D, Joseph J, Thomas R, Joshi H, Iby, Kale V, Raut N, Kandekar B, Kandekar S, Kishore R, Krishnan H, Kotiwale V, Kulkarni R, Deokar M, Kulkarni G, Lawande A, Kumar P, Karpuram M, Kumar A, Francis J, Kumbla M, Anthony A, Lavhe P, Kale M, Mardikar H, Bhaskarwar P, Mathur A, Sharma P, Menon J, Francis V, Namjoshi D, Shelke S, Narendra J, Natarajan S, Oomaan A, Gurusamy P, Angel J, Purayil MP, Shams S, Pandurangi U, Sababathi R, Parekh P, Jasani B, Patki N, Babbar A, Pinto B, Kharalkar H, Premchand R, Jambula H, Rao M, Vuriya A, Ravi Shankar A, Reddy R, Bekal S, Barai A, Saha D, Gadepalli R, Sant H, Jadhav D, Sarna M, Arora T, Sawhney J, Singh R, Sethi K, Bansal N, Sethia A, Sethia S, Shetty G, Sudheer R, Singh G, Gupta R, Srinivas A, Thankaraj L, Varma S, Kaur A, Vinod MV, Thakur B, Zanwar I, Dharmarao A, Atar S, Lasri E, Dicker D, Marcoviciu D, Elias M, Ron GA, Francis A, Ghantous R, Goldhaber A, Goldhaber M, Gottlieb S, Rouwaida S, Grossman E, Dagan T, Hasin Y, Roshrosh M, Hayek T, Majdoub A, Klainman E, Genin I, Lahav M, Gilat T, Ben Ari M, Lishner M, Karny M, Ouzan E, Givoni H, Rozenman Y, Logvinenko S, Schiff E, Sterlin J, Shochat M, Aloni I, Swissa M, Belatsky V, Tsalihin D, Kisos D, Zeltser D, Platner N, Berni A, Giovannelli F, Boriani G, Cervi E, Comi G, Peruzzotti L, Cuccia C, Forgione C, De Caterina R, De Pace D, De Servi S, Mariani M, Di Lenarda A, Mazzone C, Di Pasquale G, Di Niro M, Fattore L, Bosco B, Grassia V, Murena E, Laffi, Gaggioli G, Lo Pinto G, Raggi F, Marino P, Francalacci G, Babbolin M, Bulgari M, Penco M, Lioy E, Marciano C, Pirelli S, Paradiso G, Piseddu G, Fenu L, Raisaro A, Granzow K, Rasura M, Cannoni S, Severi S, Breschi M, Toschi V, Gagliano M, Zacà V, Furiozzi F, Hirahara T, Akihisa U, Masaki W, Ajioka M, Matsushita C, Anzai T, Mino K, Arakawa S, Tsukimine A, Endo H, Fujiwara M, Fujii K, Kozeni S, Fujii E, Kotera M, Fujimoto S, Omae K, Fujimoto K, Ichishita Y, Fujita T, Ito Y, Fukamizu S, Harada J, Fukuda N, Fujimoto C, Funazaki T, Yamaguchi A, Furukawa Y, Kamitake C, Hagiwara N, Naganuma M, Hara S, Kumagai S, Harada K, Fuki Y, Haruna T, Nakahara Y, Hashimoto Y, Shimazu Y, Hiasa Y, Oga Y, Higashikata T, Nakagawa Y, Hirayama A, Kawaguchi A, Iesaka Y, Miyamoto C, Iijima T, Higuchi K, Ino H, Noguchi H, Inomata T, Nakamura K, Ishibashi Y, Nozaki T, Ishii Y, Tomita H, Ishimaru S, Ise M, Itamoto K, Ito T, Onishi M, Iwade K, Sakuma Y, Iwasaki T, Nagatome H, Kakinoki S, Adachi C, Kamakura S, Nakahara F, Kamijo M, Iida S, Kamiyama K, Fujii R, Kato K, Ishida A, Kazatani Y, Ichikawa Y, Kitazawa H, Igarashi C, Kobayashi Y, Kikuchi R, Kohno M, Tamura S, Yumoto I, Kurabayashi M, Koya E, Masuyama T, Kaneno Y, Matsuda K, Ebina E, Meno H, Satake M, Mita T, Takeda M, Miyamoto N, Kimizu T, Miyauchi Y, Sakamoto S, Munemasa M, Murata J, Nagai Y, Sakata Y, Naito S, Oyama H, Nishi Y, Nagase T, Ochiai J, Junko H, Ogawa T, Sugeno M, Oguro H, Tanabe M, Okada K, Moriyama Y, Okajima K, Nakashima M, Okazaki O, Wada H, Okishige K, Kitani S, Okumura K, Narita Y, Onaka H, Moriyama H, Ozaki Y, Tanikawa I, Sakagami S, Nakano A, Sakuragi S, Hayashi N, Sakurai S, Ooki H, Sasaki T, Oosawa N, Satoh A, Fujimoto E, Seino Y, Narumi M, Shirai T, Shigenari M, Shoji Y, Ueda J, Sugi K, Miyazaki E, Sumii K, Asakura H, Takagi M, Mohri S, Takahashi W, Yoshida K, Takahashi A, Kishi N, Takahashi T, Sakurai Y, Takeda K, Yahata A, Takenaka T, Yamagishi K, Takeuchi S, Watanabe E, Tanaka K, Uchida M, Tanouchi J, Nishiya Y, Tsuboi H, Tsuboi N, Terakura K, Uematsu M, Yasumoto S, Ueyama Y, Usuda K, Sakai Y, Yagi M, Sato A, Yagi H, Kuroda T, Yamabe H, Sakamoto Y, Yamada T, Yamano R, Yamagishi T, Sasaki S, Yamamoto Y, Yamashina A, Takiguchi M, Yonehara T, Yoshino H, Nomura H, Yoshioka K, Fujiwara Y, Bayram Llamas E, Hurtado A, Calvo Vargas C, Limon MC, Cardona Muñoz E, Hernandez S, Carrillo J, Delgadillo T, Cásares Ramirez M, Valles JF, Garcia N, Colin MA, Garcia Castillo A, Jaramillo A, Leiva Pons J, de la Mora S, Llamas Esperón G, Grajales A, Mendez Machado G, Avila H, Ruiz LN, Magallanes G, Sánchez Díaz C, Ortiz A, Sánchez RV, Velazquez EM, Alhakim M, van Welsen I, Bruning T, Jones A, Buiks C, de Groot J, Radder I, de Vos R, Hazeleger R, Daniels R, Kietselaer B, Muijs L, Mannaerts H, Kooiman E, Mevissen H, van der Heijden D, Hofmeyer H, Anscombe R, O'Meeghan T, Kjentjes M, Benatar J, Borthwick L, Doughty R, Copley M, Fisher R, Monkley R, Green B, Scott D, Hamer A, Tomlinson J, Hart H, Turner A, Cammell R, Troughton R, Skelton L, Young C, Kennett K, Claussen H, Hofsøy K, Melbue R, Sandvik J, Thunhaug H, Tveit A, Enger S, Bustamante G, Guillen MT, Cabrera J, Mendoza RE, Chavez C, Luna C, Lema J, Carrion A, Llerena N, Bedregal SA, Medina Palomino F, Rodriguez J, Minchola J, Bautista C, Negron Miguel S, Armas BH, Rodriguez A, Romero N, Torres P, Rodriguez KF, Yanac Chavez P, Delgado S, Sambaz CM, Barcinas R, Zapanta M, Coching R, Vallenas M, Matiga G, Enad C, Rogelio G, Joaquin F, Roxas A. Jr, Gilo L, To R, Aquino M, Villamor L, Nario K, Adamus J, Korzeniowska Adamus J, Baszak J, Bronisz M, Cieslak B, Busz Papiez B, Krzystolik A, Cymerman K, Dabrowska M, Ptak A, Derlaga B, Laskowska Derlaga E, Domanska E, Guziewicz M, Gieroba A, Zajac E, Gniot J, Mroczkowski P, Januszewicz A, Makowiecka Ciesla M, Jazwinska Tarnawska E, Ciezak P, Jurowiecki J, Kaczmarek B, Pacholska A, Kaminski L, Kania G, Tymendorf K, Karczmarczyk A, Kaliszczak R, Konieczny M, Benicka E, Korzeniak R, Borowski W, Krzyzanowski W, Muzyk Osikowicz M, Kus W, Lesnik J, Wierzykowski T, Lewczuk J, Stopyra Poczatek M, Lubinski A, Szymanska K, Lysek R, Jaguszewska G, Matyszczak Toniak L, Sznajder R, Wnetrzak Michalska R, Kosmaczewska A, Mazur S, Chmielowski A, Miekus P, Kosmalska K, Mosiewicz J, Myslinski W, Napora P, Biniek D, Nessler J, Nessler B, Niezgoda K, Nej A, Nowak J, Olszewski M, Podjacka D, Janczewska D, Pogorzelska H, Polaszewska Pulkownik V, Bojanowska E, Raczak G, Zienciuk Krajka A, Rewinska H, Rozmyslowicz Szerminska W, Ronkowski R, Norwa Otto B, Sendrowski D, Spyra J, Szolkiewicz M, Malanska A, Turbak R, Wrobel W, Muzalewski P, Wysokinski A, Kudlicki J, Zarebinski M, Krauze R, Zielinski M, Nawrot M, Matias F, Correia J, Gil V, Lopes S, Madeira J, Maymone D, Martins D, Neves E, Monteiro P, Oliveira D, Marques AL, Castro C, Salgado A, Gonçalves A, Sao Marcos H, Santos O, Nunes LV, Sao Teotonio H, Santos J, Soares D, Albulescu P, Ciortea M, Apetrei E, Matei C, Bartos D, Badila E, Bengus C, Ochean V, Bobescu E, Doka B, Bolohan F, Ciobotaru G, Andor M, Coman I, Ghionea M, Constantinescu M, Creteanu M, Parasteac M, Cristea M, Anciu M, Crisu D, Jemna D, Dobre I, Voicu O, Dobreanu D, Sirbu I, Dragomir D, Jurca S, Iosipescu L, Costache L, Minescu B, Serban D, Pop C, Cozma M, Popescu M, Ardelean A, Sipciu D, Plosca P, Stamate S, Spinu C, Topolnitchi L, Topolnitchi O, Tudoran M, Tudoran C, Zhukova N, Arutyunov G, Chernyavskaya T, Ballyuzek M, Alexandrova L, Barbarash O, Bashkireva A, 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Pazier P, Riofrio K, Braun D, Robinson J, Cherrico M, Roehll W, Hollihan P, Rosado, Barnhorst M, Rosado J, Bamhorst M, Rosen R, Martin C, Ross S, Freeman R, Ruoff G, Nelson T, Sacco J, Ball E, Samal A, Schomburg J, Sandberg J, Lafave J, Savin V, Clifton R, Schaefer S, Fekete A, Schneider R, Schneider W, Schulman D, Mercer S, Seals A, Ullig T, Holt A, Seide H, Mather N, Shah G, Witt P, Shalaby A, Seese M, Shanes J, Fleets J, Shaoulian E, Hren A, Sheikh K, Hengerer T, Shih H, Browning J, Shoukfeh M, Stephenson L, Siler T, Champagne M, Simpson P, Meyer R, Singh N, Turner K, Singh V, Nelson M, Skierka R, Hughes B, Keene R, Smith R, Hodnett P, Spangenthal S, Thomason L, Sperling M, Vasquez E, Spivack E, McCartney P, Staniloae C, Liu M, Steljes A, Cox C, Struble R, Vittitow T, Suresh D, Frost J, Swerchowsky V, Freemyer D, Szulawski I, Herwehe S, Tahirkheli N, Springer K, Takata T, Bruton T, Talano J, Leo L, Tami L, Corchado D, Tatarko M, Swauger M, Tawney K, Dastoli K, Teague S, Young K, Tee H, Mitchell T, Teixeira J, Southam D, Torres M, Tucker P, Salas L, Updegrove J, Hanna K, Val Mejias J, Harrelson KG, Vemireddy D, Cardoza T, Verma S, Parsons T, Vicari R, Warren K, Vijay N, Washam M, Vossler M, Kilcup S, Walsh R, Renaud K, Ward S, Locklear T, Waxman F, Sanchez G, Weiss R, St Laurent B, Westcott J, Williams D, Gibson C, Williams R, Dowling C, Willis J, VonGerichten S, Wood K, Capasso Gulve E, Worley S, Pointer S, Yarows S, Sheehan T, Yasin M, Yi J, Dongas B, Yousuf K, Zakhary B, Curtis S, Zeig S, Mason T, Zellner C, Harden M, Roper E, Waseem M, Grammer M., PERRONE FILARDI, PASQUALE, Cardiovascular Division (SZG), Brigham and Women's Hospital [Boston], Mount Sinai Medical Center, Icahn School of Medicine at Mount Sinai [New York] (MSSM), University Hospitals Case Medical Center (CLEVELAND - UHCMC), University Hospitals Case Medical Center, Jefferson Medical College (JMC), Thomas Jefferson University Hospitals, Thrombosis and Atherosclerosis Research Institute (TARI), McMaster University [Hamilton, Ontario], University Hospital Brno, Institute of Cardiology (WARSAW - Cardiology), Institute of Cardiology, Cardiology Research Center (MOSCOU - CRC), Cardiology Research Center, National Hopital Organization (OSAKA - NHO), Osaka National Hospital, Université de Brest (UBO), Centre d'Investigation Clinique (CIC - Brest), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Graduate School, Endocrinology, ACS - Amsterdam Cardiovascular Sciences, Cardiology, Nursing, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, General Internal Medicine, Giugliano, Rp, Ruff, Ct, Braunwald, E, Murphy, Sa, Wiviott, Sd, Halperin, Jl, Waldo, Al, Ezekowitz, Md, Weitz, Ji, Špinar, J, Ruzyllo, W, Ruda, M, Koretsune, Y, Betcher, J, Shi, M, Grip, Lt, Patel, Sp, Patel, I, Hanyok, Jj, Mercuri, M, Antman, Em, Comi, Giancarlo, ENGAGE AF TIMI 48, Investigators, Robert P., Giugliano, Christian T., Ruff, Eugene, Braunwald, Sabina A., Murphy, Stephen D., Wiviott, Jonathan L., Halperin, Albert L., Waldo, Michael D., Ezekowitz, Jeffrey I., Weitz, Jind?ich, ?pinar, Witold, Ruzyllo, Mikhail, Ruda, Yukihiro, Koretsune, Joshua, Betcher, Minggao, Shi, Laura T., Grip, Shirali P., Patel, Indravadan, Patel, James J., Hanyok, Michele, Mercuri, Elliott M., Antman, Morin, Se, Hoffman, Eb, Deenadayalu, N, Grip, L, Lanz, H, Curt, V, Duggal, A, Hanyok, J, Davé, J, Morgan, D, Choi, Y, Jin, J, Xie, J, Crerand, W, Kappelhof, J, Maxwell, W, Skinner, M, Patel, S, Selicato, G, Otto C., Jr, Reissner, C, Smith, K, Ostroske, J, Ron, A, Giugliano, R, Connolly, S, Camm, J, Ezekowitz, M, Halperin, J, Waldo, A, Paolasso, E, Aylward, P, Heidbuchel, H, Nicolau, Jc, Goudev, A, Roy, D, Weitz, J, Corbalán, R, Yang, Y, Botero, R, Bergovec, M, Ŝpinar, J, Grande, P, Hassager, C, Voitk, J, Huikuri, H, Nieminen, M, Blanc, Jj, Leheuzey, Jy, Mitrovic, V, Alexopoulos, D, Sotomora, G, Kiss, R, Somaraju, B, Lewis, B, Merlini, P, Metra, M, Yamashita, T, García 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Grammer, M.
- Subjects
Male ,Pyridines ,[SDV]Life Sciences [q-bio] ,Embolism ,Kaplan-Meier Estimate ,030204 cardiovascular system & hematology ,chemistry.chemical_compound ,0302 clinical medicine ,Edoxaban ,Atrial Fibrillation ,MESH: Double-Blind Method ,030212 general & internal medicine ,MESH: Warfarin ,Stroke ,MESH: Aged ,MESH: Middle Aged ,Cardiovascular diseases [NCEBP 14] ,Hazard ratio ,General Medicine ,MESH: Follow-Up Studies ,Middle Aged ,3. Good health ,MESH: Atrial Fibrillation ,Cardiovascular Diseases ,Anesthesia ,Cardiology ,Female ,Adult ,Aged ,Anticoagulants ,Double-Blind Method ,Follow-Up Studies ,Hemorrhage ,Humans ,Thiazoles ,Warfarin ,MESH: Hemorrhage ,Andexanet alfa ,medicine.drug ,medicine.medical_specialty ,MESH: Enoxaparin ,MESH: Anticoagulants ,MESH: Stroke ,Dabigatran ,03 medical and health sciences ,Internal medicine ,medicine ,MESH: Kaplan-Meier Estimate ,Rivaroxaban ,MESH: Humans ,business.industry ,MESH: Cardiovascular Diseases ,MESH: Adult ,medicine.disease ,Confidence interval ,MESH: Male ,chemistry ,business ,MESH: Female ,MESH: Embolism - Abstract
Contains fulltext : 125374.pdf (Publisher’s version ) (Open Access) BACKGROUND: Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. METHODS: We conducted a randomized, double-blind, double-dummy trial comparing two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high-risk atrial fibrillation (median follow-up, 2.8 years). The primary efficacy end point was stroke or systemic embolism. Each edoxaban regimen was tested for noninferiority to warfarin during the treatment period. The principal safety end point was major bleeding. RESULTS: The annualized rate of the primary end point during treatment was 1.50% with warfarin (median time in the therapeutic range, 68.4%), as compared with 1.18% with high-dose edoxaban (hazard ratio, 0.79; 97.5% confidence interval [CI], 0.63 to 0.99; P
- Published
- 2013
5. Impact of Spontaneous Extracranial Bleeding Events on Health State Utility in Patients with Atrial Fibrillation: Results from the ENGAGE AF‐TIMI 48 Trial
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Senior, R., Paul, J., McKnight, T., Formoso, I., Saravia Toledo, S., Codutti, O., Sanjurjo, M., Bowen, L., Sanchez, A., Alvarez, M., Rodriguez, M., Navarrete, S., Ramos, H., Venturini, C., Prado, A., Fernandez, E., Pozzer, D., Casares, E., Povedano, G., Tommasi, A., Piskorz, D., Verdini, E., Nul, D., Gandur, H., Muntaner, J., Funes, I., Marino, J., Calderon, M., Manuale, O., Carne, M., Mackinnon, I., Raimondi, G., Lotti, J., Shatsky, K., Rodkey, K., Lorente, C., Vignau, S., Llanos, J., Nigro, A., Litvak, B., Iglesias, M., Liniado, G., Belcuore, M., Lanternier, G., Monaco, F., Kevorkian, R., Jure, D., Jure, H., Bianchini, M., Avery, D., Hominal, M., von Wulffen, M., McKenzie, M., Miranda, J., Wright, L., Pye, M., Flint, L., Newby, D., Andrews, A., Goicoechea, R., Huerta, M., Giannaula, R., Eden, M., Giacomi, G., Ceirano, C., Garrido, M., Perlo, D., Garcia Duran, R., Meiller, F., Gant Lopez, J., Zanotti, A., Fuselli, J., Arrieta, M., Femenia, F., Falu, E., Facello, M., Facello, A., Murdoch, D., Helliwell, L., More, R., Isted, C., Maxwell, T., Jones, D., Marazzi, P., McGhee, C., MacLeod, M., Ebano, P., MacCallum, P., Davolos, M., Estol, C., Moreno, V., Dran, R., Cendali, G., D'Amico, A., Bocanera, M., Cuneo, C., Rosell, M., Cuello, J., Morandini, M., Colombo, H., Brown, R., Saa Zarandon, R., Caruso, O., Novas, V., Cartasegna, L., Fracaro, V., Caccavo, A., Saravia, M., Bustamante Labarta, G., Valle, M., Budassi, N., Lip, G., Finlayson, M., Linker, N., McGuire, K., Atkinson, C., Lindsay, S., Ramasamy, V., Lie, F., Dickinson, D., Douglas, H., D'Costa, D., Wilmott, R., Cohen, A., Duff, J., Choy, A., Davies, D., Chapman, O., Dougal, K., Camm, J., Price, R., Blagden, M., Schwarz, L., McGarvey, J., Stubbs, L., McCartney, M., Hicks, T., Massin, E., Bedenko, E., Marenberg, M., Rabadi-Marar, D., Dunn, S., Beeton, I., Smith, S., Aggarwal, R., Marar, I., Hernandez, S., Berli, M., Petrucci, J., Beloscar, J., Caceres, M., Amuchastegui, M., Ameriso, P., Ameriso, S., Garcia, M., Alvarez, C., Reguero, M., Allall, O., Rosales, E., Albisu, J., Ahuad Guerrero, R., Gonzalez, C., Vogelmann, O., Magnuson, Elizabeth A., Cohen, David J., Giugliano, Robert P., Mandviwala, M., Casas, R., Makam, S., Lisiecki, B., Mainigi, S., Doctor, A., Magee, A., Bush, D., Macomber, J., Edelstein, J., Lurie, M., Wright, H., Lui, H., Ault, S., Looby, R., Davids, M., Lone, B., Shah, D., Lomnitz, D., Wofford, E., Littlefield, R., Murphy, R., Ling, L., Miller, D., Lillestol, M., Bonds, C., Lewis, D., Hartley, L., Lesser, M., Smith, D., Lentz, M., Royse, H., Ledbetter, L., Faucett, S., Langevin, E., Simmons, T., Lang, J., Ferguson, D., Landau, C., Coyle, G. 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D., Herrod, J., Batchell, K., Hermany, P., Harkins, V., Henry, S., Millard, D., Henderson, D., Dandekar, U., Heiman, M., Krater, C., Hearne, S., Bobade, M., Harris, J., Cavanna, L., Han, M., Bentivenga, L., Hamroff, G., Morelli, L., Hack, T., McLean, R., Gvora, T., Felsman, D., Guthrie, R., Foster, B., Guerrero, Guerrero, Fisher, M., Guarnieri, T., Gabela, W., Guarino, J., Mabe, K., Grove, D., Davis, A., Grossman, C., Goodman, V., Griffin, J., Aull, L., Griffin, S., Bonora, M., Graham, S., Rafala, E., Gowda, S., Goldstein, M., Latteri, J., Goldscher, D., Ewing, B., Gogia, H., Keane-Richmond, P., Gillespie, E., Hinchion, N., Gerber, J., Valentine, H., George, F., Garb, J., Jones, J., Gaffney, M., Smith, K., Friedlander, I., Morales, C., French, W., Gentry, P., Franco, M., Thrope, C., Frais, M., Solis, A., Forman, S., Slayton, C., Flores, E., Donahue, S., Fishbein, G., Drew, B., Fischell, T., Lim, G., Finkelstein, S., Shriver, D., Finkel, M., Calvo, M., Fialkow, J., Prior, J., Felten, W., Tang, N., Feldman, J., Tameron, A., Feld, L., Watkins, D., Fahmy, R., DeSalle, D., Everhart, B., Shipp, A., Ettinger, N., O'Brien, J., Johnson, C., Erenrich, N., Cristaldi, J., Ellis, J., Quick, R., Eldadah, Z., Dunn, K., Eade, J., Cullen, T., D'Souza, A., Habibi, S., Drozdiak, R., Olson, A., Dotani, I., Rodriguez, L., Donovan, D., Tisdale, L., DiGiovanna, M., Ucik, S., Dhar, S., Briscoe, C., Devenport, S., Waters, L., Desire, A., Steward, A., Desai, A., Carey, J., DeGarmo, R., Warmack, D., Dean, J., Debes, C., De Lemos, J., Ebreo, N., Davuluri, A., Dave, B., Dave, K., Wulf, A., Datta, S., Leka, G., Daniels, S., Morgan, T., Dang, N., Sarpola, N., Curtis, B., Nelson, L., Cowan, L., Masson, E., Cottiero, R., Mullinax, K., Cossu, S., Svadbik, L., Corbett, B., Martinez, E., Concha, M., Cole, J., Salpas, S., Colan, D., Bossaers, J., Cohen, R., Dutka, C., McClelland, M., Clay, A., Clapp, T., Bagby, J., Ciaramita, J., Sawaya, K., Chaturvedi, S., Tamayo, M., Charlat, M., Hatfield, G., 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L., Fedotov, S., Malynovsky, Y., Gorna, O., Lizogub, V., Kyyak, Y., Kupnovytska, I., Stets, R., Kraydashenko, O., Usan, N., Kraiz, I., Kaplan, P., Koval', O., Ohirko, O., Koval, V., Dvoieglazova, M., Kotseruba, V., Petyunina, O., Kopytsya, M., Vasylets, V., Kolomyyits, S., Gerasimenko, N., Kaydashev, I., Blihar, O., Karpenko, Y., Nevolina, I., Karpenko, O., Samburg, Y., Godlevska, O., Husyev, V., Horbach, L., Dzublik, Y., Gavrysyuk, V., Sorokivskyy, M., Faynyk, A., Vasilyeva, L., Dzyak, G., Kulynych, R., Dotsenko, S., Lebedynskaya, M., Bereznyakov, I., Vlasyuk, Z., Bazylevych, A., Azhdari, M., Batushkin, V., Zoghi, M., Yigit, Z., Yigit, F., Tandogan, I., Turgut, O., Oto, A., Kanadasi, M., Kabul, K., Ermis, C., Erdogan, D., Ceyhan, C., Cayli, M., Calik, A., Cakmak, N., Bayata, S., Ata, N., Demir, H., Akilli, H., Acikel, M., Puripun, E., Vorasettakarnkij, Y., Mekara, W., Sukonthasarn, A., Panpunuan, P., Sritara, P., Sripracha, A., Piyayotai, D., Bamrungpong, P., Laothavorn, P., Sriprasert, S., Kiatchoosakun, S., Sinthusopa, W., Kaewsuwanna, P., Pornchaiyasit, K., Jirasirirojanakorn, K., Kuo, J. Y., Yeh, H. I., Tsai, W. C., Lee, S. C., Ueng, K. C., Pan, Y. F., Tseng, W. K., Chiu, C. Z., Shyu, K. G., Lin, K. H., Pai, P. Y., Lee, J. T., Lin, T. H., Lai, W. T., Wang, C. L., Kuo, C. T., Chen, Y. F., Huang, J. L., Chen, Y. P., Hsia, C. H., Yeh, T. C., Chiou, C. W., Wu, Y. W., Chiang, F. T., Yu, W. C., Chiang, C. E., Wu, W. S., Cheng, C. C., Slater, I. Petrova, Moccetti, T., Broberg, M., Thulin, J., Gunnarsson, A., Stenberg, A., Sundholm, C., Ronn, F., Johansson, M., Rautio, A., Moodh, J., Randers, F., Eriksson, G., Malmqvist, L., Edlund, M., Kozak, P., Hakansson, E., Koskinen, P., Jernhed, H., Juul-Moller, S., Winberg, L., Herlitz, J., Karlsson, L., Engdahl, J., Ostberg, S., Dettmann, S., Bengtsson, A. Stener, Carlsson, T., Persson, L., Blomstrom, P., Andersson, R., Blom, K. Berndtsson, Akerberg, A., Appelros, P., Astier, L., Villuendas, R., Dachs Delgado, M., Terns, M., Fernandez Alvarez, R., Fernandez, M., Arias, J., Diaz-Pintado, M., Merino, J., Blanco Abril, S., Manzano, L., Barquero, R., Lopez Garcia-Aranda, V., Delgado, A., Hernandez Madrid, A., Moure, M., Gonzalez Juanatey, J., Perez Guevara, M., Diez Tejedor, E., Asensio, A., De Arce Borda, A., Calvo, G., Calvo, C., Cabero, P., Bruguera Cortada, J., Puertas, I., Blanco Coronado, J., Manzanal Rey, A., Arcocha Torres, M., Kim, J. Y., Rim, S. J., Na, J. O., Rha, S. W., Kwak, J. J., Namgung, J., Shin, D. G., Lee, S. H., Joung, B. Y., Lee, M. H., Chun, M. Y., Kim, Y. J., Seo, J. B., Kim, S. H., Park, S. J., Kim, J. S., Park, J. H., Kim, J. H., Park, M. S., Kim, J. T., Cha, M. J., Kim, H. S., Seo, J. S., Kim, D. S., Jin, E. S., Kim, C. J., Choi, K. J., Kang, D. H., Lee, J. M., Jeon, H. K., Jung, J. W., Hyon, M. S., Lee, H. W., Hong, T. J., Lee, K. H., Han, S. H., Oh, Y. S., Chung, W. S., Hong, K. S., Choi, H. H., Ryu, D. R., Cho, B. R., Kim, D. H., Cha, J. K., Han, M. G., Bae, H. J., Wessels, L., Venter, T., Le Roux, M., Van Zyl, L., Goosen, Y., Van Der Merwe, N., Johnston, H., Soma, P., Munnik, M., Snyders, F., Duki, Y., Naidoo, D., Taljaard, J., Mitha, I., Kelfkens, Y., Wilson, L., Gani, M., Nunkoo, T., Essop, M., Mostert, M., Engelbrecht, J., Botha, L., Ellis, G., Allman, J., Dalby, A., Poynton, M., Basson, M., Erasmus, L., Badenhorst, J., Bollova, D., Zareczky, P., Kokles, M., Zachar, A., Kmec, J., Slanina, M., Morsky, J., Ruffini, L., Fedacko, J., Pella, D., Mazur, J., Reptova, A., Kasperova, V., Hofmanova, J., Hranai, M., Hatala, R., Hatalova, K., Dzupinova, M., Dzupina, A., Vankova, L., Duris, T., Dulka, T., Dulkova, K., Kosmalova, V., Dukat, A., Banikova, A., Ambrovic, I., Ambrovicova, V., Tesic, M., Golshmid, M., Ruda, M., Topolnitchi, O., Castro, C., Ostojic, M., Tesic, B. 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L., Zhou, S. X., Li, B. G., Zheng, Z. Q., Wang, J. Q., Zhao, X. L., Han, R. J., Zhao, R. P., Kang, H., Zhang, Z., Lin, Y. N., Zhang, H. Q., Qiang, H., Yuan, Z. Y., Li, L. L., Yu, B., Xu, Y. P., Yin, Y. H., Gao, M., Zheng, Y., Zheng, X., Yang, Y. J., Li, A. Y., Yang, K., Liang, Y. Z., Xu, Y. M., Gu, J. Y., Xu, J. H., Li, Y. E., Wu, S. L., Huang, D., Wei, M., Shi, X. J., Wang, G. P., Qi, S. Y., Wang, D. M., Yang, Z. Y., Ma, S. M., Lu, Z. H., Liu, L., Gu, X. J., Liao, D. N., Liu, Y., Li, Z. Q., Liu, B., Li, W. M., Kong, Y. Q., Li, T. F., Liu, H., Li, L., Qu, Z., Jiang, X. J., Qiu, Y., Hong, L., You, Z. G., Hong, K., Zhang, P., Fu, G. S., Feng, C., Dong, Y. G., Zhang, X., Chen, X. P., Xie, X. D., Chen, J. Z., Xu, G. 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Burger, Zimmermann, S., Almeida, M., Boas, F. Villas, Lustosa, E., Sobral Filho, D., Carraro, A., Simoes, M., Vicente, C., Saraiva, J., do Val, R., Sampaio, R., Pagnan, L. Goncalves, dos Santos, F. Rossi, Rodrigues, D., Rodrigues, A., Rocha, M. Rubia, Rodrigues, L., Barros, R., Rocha, J., Leipelt, J., Katz Weiand, L. Reis, Avellar, K., Reis, G., Gozalo, A., Almeida, J. Pimenta, Luiz, R. Osorio, Leaes, P., Morales, K., Sebba Barroso de Souza, W. Kunz, Radaelli, G., Kalil, C., Almeida, A., Kaiser, S., Cury, C., Jorge, J., Pereira, L., Jaeger, C., Ninho, L., Guimaraes, A., Gomes, A., Gomes, M., Pereira, G., Gagliardi, R., Daitz, C., Finimundi, H., Araujo, E., Ferreira, L., Seroqui, M., Saporito, W. Faustino, Morgado, S., Dutra, O., Laimer, R., Duda, N., Pereira, V., De Patta, M., Barroso, D., Costantini, C., Silva, J., Chaves Junior, H., Fleck, N., Brondani, R., Cunha, S., Botelho, R., Sehnem, E., Precoma, D. Bertolim, Ferraz, R. Franchin, Alves da Costa, F. Augusto, Motta, C., Atie, J., de Melo, R. Ferreira, Lotufo, P. Andrade, Coutinho, E., Vincenzo de Paola, A. Amato, Denie, D., Wollaert, B., Beerts, C., Vrolix, M., Mestdagh, I., Vervoort, G., van Welden, J., Vanwelden, J., Derycker, K., Vandekerckhove, Y., Jacobs, C., Mehrle, A., Skinner, J., Meholick, A., Marti, J., Mega, J., Lack, A., Stockman, D., Huyberechts, D., Scavee, C., Clinckemaille, N., Parque, J., Raepers, M., Mairesse, G., Malmendier, D., Herzet, J., Meeusen, K., Heidbuchel, H., Tincani, G., Desfontaines, P., De Bruyne, L., De Tollenaere, M., de Koning, K., De Bleecker, J., Banaeian, F., Capiau, L., O'Shea, V., Szto, G., Perrett, L., Purnell, P., Batta, C., Paul, V., Li, J., McKeirnan, M., Morrison, H., Wright, J., Wright, A., Chung, A., Watkin, R., Gilchrist, M., Venkataraman, A., Lehman, R., Jones, S., Gates, P., Flecknoe-Brown, S., Silver, G., Davis, S., Kay, S., Dart, A., Slattery, A., Crimmins, D., Price-Smith, S., Colquhoun, D., Hoffmann, B., Arstall, M., Paraskevaidis, T., Anderson, C., Morell, Y., Vico, M., Teves, M., Sosa Liprandi, M., Morara, P., Severino, P., Buzzetti, C., Schygiel, P., Walker, M., Turner, W., Bridge, C., Storey, R., Goloboulicz, A., Schmidberg, J., Kennard, S., Sopher, M., McLaurin, B., Young, G., Kwong, Winghan J., Antman, Elliott M., Ruff, Christian T., Wang, J. H., Iriarte, M., Morissette, A., Wang, Kaijun, Li, Haiyan, and Yalcin, R.
- Subjects
Male ,medicine.medical_specialty ,Complications ,Time Factors ,Pyridines ,Health Status ,Embolism ,Hemorrhage ,Arrhythmias ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Risk Factors ,Surveys and Questionnaires ,Internal medicine ,Atrial Fibrillation ,Humans ,Medicine ,In patient ,Prospective Studies ,030212 general & internal medicine ,anticoagulation ,Blood Coagulation ,Original Research ,Aged ,Aged, 80 and over ,Quality and Outcomes ,business.industry ,Anticoagulants ,Atrial fibrillation ,Middle Aged ,bleeding ,medicine.disease ,Stroke ,Thiazoles ,Treatment Outcome ,quality of life ,utility ,Physical therapy ,Cardiology ,Female ,Warfarin ,Gastrointestinal Hemorrhage ,Cardiology and Cardiovascular Medicine ,business ,TIMI ,Health Services and Outcomes Research ,Factor Xa Inhibitors - Abstract
Background The impact of different types of extracranial bleeding events on health‐related quality of life and health‐state utility among patients with atrial fibrillation is not well understood. Methods and Results The ENGAGE AF ‐ TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation–Thrombolysis in Myocardial Infarction 48) Trial compared edoxaban with warfarin with respect to the prevention of stroke or systemic embolism in atrial fibrillation. Data from the EuroQol‐5D ( EQ ‐5D‐3L) questionnaire, prospectively collected at 3‐month intervals for up to 48 months, were used to estimate the impact of different categories of bleeding events on health‐state utility over 12 months following the event. Longitudinal mixed‐effect models revealed that major gastrointestinal bleeds and major nongastrointestinal bleeds were associated with significant immediate decreases in utility scores (−0.029 [−0.044 to −0.014; P P =0.001], respectively). These effects decreased in magnitude over time, and were no longer significant for major nongastrointestinal bleeds at 9 months, but remained borderline significant for major gastrointestinal bleeds at 12 months. Clinically relevant nonmajor and minor bleeds were associated with smaller but measurable immediate impacts on utility (−0.010 [−0.016 to −0.005] and −0.016 [−0.024 to −0.008]; P Conclusions All categories of bleeding events were associated with negative impacts on health‐state utility in patients with atrial fibrillation. Major bleeds were associated with relatively large immediate decreases in utility scores that gradually diminished over 12 months; clinically relevant nonmajor and minor bleeds were associated with smaller immediate decreases in utility that persisted over 12 months. Clinical Trial Registration URL: https://www.clinicaltrials.gov/ . Unique identifier: NCT00781391.
- Published
- 2017
6. A phase II trial of docetaxel plus cisplatin in recurrent and/or metastatic non-squamous cell carcinoma of head and neck
- Author
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Imamura, Y., primary, Kiyota, N., additional, Tanaka, K., additional, Hayashi, H., additional, Ota, I., additional, Nario, K., additional, Hirano, S., additional, Arai, A., additional, Iwae, S., additional, Onoe, T., additional, Minami, S., additional, Shimada, T., additional, Yane, K., additional, Yamazaki, T., additional, Nagatani, Y., additional, Toyoda, M., additional, Otsuki, N., additional, Nibu, K.-I., additional, and Minami, H., additional
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- 2018
- Full Text
- View/download PDF
7. Outcomes With Edoxaban Versus Warfarin in Patients With Previous Cerebrovascular Events Findings From ENGAGE AF-TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48)
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Pan, Y. F., Lim, G., Desire, A., Tseng, W. K., Rost, Natalia S., Grammer, M., Khetarpal, S., Waseem, M., Zellner, C., Roper, E., Amin, M., Harden, M., Sababathi, R., Valpas, S., Bourlios, P., Kawaguchi, A., Mavronasiou, E., Pandurangi, U., Shams, S., Dichristin, U., Purayil, M. Padinhare, Munemasa, M., Angel, J., Gurusamy, P., Berni, A., Platner, N., Zeltser, D., El Jarroudi, M., Kisos, D., Haruna, T., Bernhardt, P., Coisne, D., Nakahara, Y., Li, W. M., Karamitsos, C., Tziortziotis, A., Essop, M., Nunkoo, T., Gani, M., Wilson, L., Kelfkens, Y., Mitha, I., Taljaard, J., Naidoo, D., Duki, Y., Snyders, F., Munnik, M., Soma, P., Johnston, H., Patki, N., Jasani, B., Van Der Merwe, N., Goosen, Y., Van Zyl, L., Le Roux, M., Venter, T., Wessels, L., Bae, H. J., Han, M. G., Cha, J. K., Kim, D. H., Cho, B. R., Ryu, D. R., Choi, H. H., Hong, K. S., Chung, W. S., Oh, Y. S., Han, S. H., Lee, K. H., Hong, T. J., Lee, H. W., Hyon, M. S., Jung, J. W., Jeon, H. K., Lee, J. M., Kang, D. H., Choi, K. 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Rostasne, Palinkas, A., Berk, M., Nagy, A., Garman, V., Bensimhon, D., Swaim, D., Beinart, S., Craig, M., Bedwell, N., Luis-Valdes, M., Bedoya, R., Hoffman, T., Beasley, R., Kolumban, E., Merkely, B., Kiss, K., Wulf, M., Takeda, M., Benton, J., Bartkowiak, A., Gordon, L., Erdogan, D., Barrington, P., Faircloth, C., Barker, T., Altonen, D., Barber, M., Campbell, G., Baman, R., Batista, M., Baine, S., Thompson, B., Ayesu, K., Ermis, C., Alvarez, M., Sanchez, A., Bowen, L., Sanjurjo, M., Codutti, O., Saravia Toledo, S., Formoso, I., Schmidberg, J., Baldwin, E., Awasty, V., Cobos, D., Aude, Y., Strickland, S., Medvegy, M., Kiss, T., Attanti, S., Matoltsy, A., Rasmussen, L., Arouni, A., Shoaf, R., Arnold, T., York, T., Kabul, K., Kanadasi, M., Goloboulicz, A., Anderson, J., Schygiel, P., Buzzetti, C., Severino, P., Morara, P., Sosa Liprandi, M., Teves, M., Vico, M., Oto, A., Turgut, O., Persechino, F., Morell, Y., Amin, K., Lane, B., Alsheikh, T., MacDonald, H., Almquist, A., Anderson, C., Paraskevaidis, T., Kolk, R., Tandogan, I., Stern, A., Yigit, F., Yigit, Z., Arstall, M., Hoffmann, B., Colquhoun, D., Price-Smith, S., Crimmins, D., Slattery, A., Karakai, H. Horvathne, Lupkovics, G., Di Lenarda, A., Kovacs, Z., Gadepalli, R., Mariani, M., Kumagai, S., Luttermann, M., Krishnan, H., Dart, A., Venneklaas, U., Kay, S., Lueders, S., De Servi, S., Grosse, B., Davis, S., Baranyai, M., Silver, G., Flecknoe-Brown, S., Gates, P., Kovacs, I., Salminen, O., Koczka, M., Jakal, A., Jones, S., Pirelli, S., Lohrbaecher-Kozak, I., Bauch, F., Koenig, H., Lehman, R., Kiss, R., Saha, D., Barai, A., Roy, D., Bekal, S., Feil, J. Felfoldine, Meusel, P., Morrison, H., Biscardi, R., Kis, E., Hirayama, A., Allison, J., Godsey, W., Aliyar, P., Genova-Peeva, E., Kosztyu, M., Kleinecke-Pohl, U., Alexander, J., Brubaker, S., Akhter, F., Schoen, B., Reddy, R., Shankar, A. Ravi, Jungmair, W., Schmid, S., Junggeburth, J., De Pace, D., Ahmadpour, H., De Caterina, R., Hussain, A., Kaik, J., Ahmad, A., Beck, P., Zoghi, M., Batushkin, V., Fink, P., Reiling, S., Miyamoto, N., Adler, P., McKeirnan, M., Li, J., Paul, V., Batta, C., Serup-Hansen, K., Vuriya, A., Horacek, T., Schuppe, M., Kanakaridisz, N., Varga, A., Kimizu, T., Purnell, P., Perrett, L., Kishore, R., Szto, G., O'Shea, V., Capiau, L., Banaeian, F., De Bleecker, J., de Koning, K., De Tollenaere, M., Kara, M., Fiok, J., Szatmari, J., De Bruyne, L., Edes, I., Tsukimine, A., Muskoczki, E., Wiggers, H., Jakobsen, U., Torp-Pedersen, C., Forgione, C., Harada, K., Dioszeghy, P., Almaraz, S. Padilla, Desfontaines, P., Tincani, G., Heidbuchel, H., Camas, L. Velasquez, Cuccia, C., Meeusen, K., Herzet, J., Malmendier, D., Guerra, L., Mairesse, G., Raepers, M., Parque, J., Clinckemaille, N., Scavee, C., Samayoa, C. Sanchez, Pozuelos, J. Mayen, Arakawa, S., Huyberechts, D., Stockman, D., Jacobs, C., Vandekerckhove, Y., Svenningsen, A., Sand, N., Azhdari, M., Derycker, K., Peruzzotti, L., Comi, G., Vanwelden, J., Mino, K., Cervi, E., Sanchez, M., Gilat, T., van Welden, J., Vervoort, G., Mestdagh, I., Vrolix, M., Bazylevych, A., Vlasyuk, Z., Raae, D., Raymond, I., Beerts, C., Wollaert, B., Denie, D., Vincenzo de Paola, A. Amato, Coutinho, E., Lotufo, P. Andrade, de Melo, R. Ferreira, Atie, J., Motta, C., Alves da Costa, F. Augusto, Lahav, M., Estrada, M. Rodas, Ferraz, R. Franchin, Precoma, D. Bertolim, Guevara, S., Contzen, C., Weihrauch, D., Sehnem, E., Botelho, R., Cunha, S., Brondani, R., Fleck, N., Buhr, M., Kandekar, S., Ladenburger, K., Lavagnino, A. Ovando, Braun, R., Ishimaru, S., Chaves Junior, H., Silva, J., Costantini, C., Barroso, D., Jimenez, T., De Patta, M., Pereira, V., Duda, N., Bereznyakov, I., Laimer, R., Tomita, H., Ishii, Y., Dutra, O., Morgado, S., Saporito, W. Faustino, Seroqui, M., Ferreira, L., Araujo, E., Finimundi, H., Daitz, C., Gagliardi, R., Pereira, G., Gomes, M., Gomes, A., Guimaraes, A., Lebedynskaya, M., Petrovic, V., Overgaard, K., Ninho, L., Olsen, R., Nielsen, H., Jaeger, C., Barash, B., Veng-Olsen, T., Dotsenko, S., Pereira, L., Iversen, H., Madsen, H., Kulynych, R., Dzyak, G., Vasilyeva, L., Faynyk, A., Sorokivskyy, M., Gavrysyuk, V., Schnelzer, P., Ibsen, H., Adler, J., Dzublik, Y., Horbach, L., Husyev, V., Bouzo, M., Babbar, A., Loof, A., Blanc, J., Godlevska, O., Melgar, I. Guzman, Marcoviciu, D., Ramirez, V. de Leon, Sehr, B., Beyer-Westendorf, J., Vierbeck, S., Decoulx, E., Samburg, Y., Jorge, J., Cury, C., Karpenko, O., Hassager, C., Milla, O. Ayau, Kaiser, S., Christensen, L., Christensen, H., Dodt, K., Zidkova, E., Samkova, D., Vodnansky, P., Almeida, A., Kalil, C., Radaelli, G., Sebba Barroso de Souza, W. Kunz, Morales, K., Labrova, R., Nevolina, I., Karpenko, Y., Leaes, P., Luiz, R. Osorio, Blihar, O., Kaydashev, I., Berbari, H., Spinar, J., Spacek, R., Almeida, J. Pimenta, Gozalo, A., Slaby, J., Reichert, P., Jirsova, E., Podrazil, P., Gerasimenko, N., Pisova, J., Exarchou, E., Havlova, I., Petrova, I., Kifnidis, K., Reis, G., Kolomyyits, S., Peterka, K., Olsr, J., Bansal, N., Nechanicky, R., Vasylets, V., Kopytsya, M., Melichar, M., Krocova, E., Machova, V., Ludka, O., Petyunina, O., Kotseruba, V., Berrouschot, J., Kvasnicka, J., Avellar, K., Kuchar, R., Kovar, P., Katz Weiand, L. Reis, Korantanis, K., Kosek, Z., Kostkova, G., Leipelt, J., Rocha, J., Ishibashi, Y., Lohman, J., Panella, M., Nozaki, T., Abi-Mansour, P., Dvoieglazova, M., Pyrgakis, V., Koval, V., Ohirko, O., Kochrt, M., Kobza, R., Koval', O., Jirmar, R., Sakamoto, S., Jerabek, O., Jelinek, Z., Jarkovsky, P., Jandik, J., Hubac, J., Honkova, M., Barros, R., Gregor, P., Rao, M., Jambula, H., Golan, L., Anzai, T., Rodrigues, L., Rocha, M. Rubia, Rodrigues, A., Rodrigues, D., dos Santos, F. Rossi, Pagnan, L. Goncalves, Sampaio, R., do Val, R., Saraiva, J., Francek, L., Florian, J., Ferkl, R., Elbl, L., Cermak, O., Burianova, H., Brtko, M., Pinto, B., and Yalcin, R.
- Subjects
Male ,medicine.medical_specialty ,Pyridines ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Brain Ischemia ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Double-Blind Method ,Recurrence ,Edoxaban ,Internal medicine ,Atrial Fibrillation ,parasitic diseases ,Secondary Prevention ,medicine ,Humans ,Myocardial infarction ,cardiovascular diseases ,Stroke ,Aged ,Advanced and Specialized Nursing ,business.industry ,Hazard ratio ,Warfarin ,Anticoagulants ,Atrial fibrillation ,Thrombolysis ,Middle Aged ,medicine.disease ,nervous system diseases ,Thiazoles ,Treatment Outcome ,chemistry ,Anesthesia ,Cardiology ,Female ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,030217 neurology & neurosurgery ,TIMI ,medicine.drug - Abstract
Background and Purpose— Patients with atrial fibrillation and previous ischemic stroke (IS)/transient ischemic attack (TIA) are at high risk of recurrent cerebrovascular events despite anticoagulation. In this prespecified subgroup analysis, we compared warfarin with edoxaban in patients with versus without previous IS/TIA. Methods— ENGAGE AF-TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48) was a double-blind trial of 21 105 patients with atrial fibrillation randomized to warfarin (international normalized ratio, 2.0–3.0; median time-in-therapeutic range, 68.4%) versus once-daily edoxaban (higher-dose edoxaban regimen [HDER], 60/30 mg; lower-dose edoxaban regimen, 30/15 mg) with 2.8-year median follow-up. Primary end points included all stroke/systemic embolic events (efficacy) and major bleeding (safety). Because only HDER is approved, we focused on the comparison of HDER versus warfarin. Results— Of 5973 (28.3%) patients with previous IS/TIA, 67% had CHADS 2 (congestive heart failure, hypertension, age, diabetes, prior stroke/transient ischemic attack) >3 and 36% were ≥75 years. Compared with 15 132 without previous IS/TIA, patients with previous IS/TIA were at higher risk of both thromboembolism and bleeding (stroke/systemic embolic events 2.83% versus 1.42% per year; P P P P =0.02). No treatment subgroup interactions were found for primary efficacy ( P =0.86) or for intracranial hemorrhage ( P =0.28). Conclusions— Patients with atrial fibrillation with previous IS/TIA are at high risk of recurrent thromboembolism and bleeding. HDER is at least as effective and is safer than warfarin, regardless of the presence or the absence of previous IS or TIA. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00781391.
- Published
- 2016
8. Cardioversion of Atrial Fibrillation in ENGAGE AF-TIMI 48
- Author
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Perrone, Lioy, E., Penco, M., Bulgari, M., Metra, M., Babbolin, M., Merlini, P., Francalacci, G., Marino, P., Raggi, F., Lo Pinto, G., Gaggioli, G., Laffi, Laffi, Murena, E., Grassia, V., Bosco, B., Fattore, L., Di Niro, M., Di Pasquale, G., Mazzone, C., Di Lenarda, A., Mariani, M., De Servi, S., De Pace, D., De Caterina, R., Forgione, C., Cuccia, C., Peruzzotti, L., Comi, G., Cervi, E., Boriani, G., Giovannelli, F., Berni, A., Platner, N., Zeltser, D., Kisos, D., Tsalihin, D., Belatsky, V., Swissa, M., Aloni, I., Shochat, M., Sterlin, J., Schiff, E., Logvinenko, S., Rozenman, Y., Givoni, H., Ouzan, E., Karny, M., Lishner, M., Ben Ari, M., Lewis, B., Genin, I., Klainman, E., Majdoub, A., Hayek, T., Roshrosh, M., Hasin, Y., Dagan, T., Grossman, E., Rouwaida, S., Gottlieb, S., Goldhaber, M., Goldhaber, A., Ghantous, R., Francis, A., Ron, G. Avraham, Elias, M., Gilat, T., Lahav, M., Marcoviciu, D., Dicker, D., Lasri, E., Atar, S., Dharmarao, A., Zanwar, I., Thakur, B., Vinod, M. 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Rostasne, Palinkas, A., Nagy, A., Kolumban, E., Merkely, B., Kiss, K., Medvegy, M., Kiss, T., Matoltsy, A., Karakai, H. Horvathne, Lupkovics, G., Kovacs, Z., Baranyai, M., Kovacs, I., Koczka, M., Jakal, A., Kiss, R., Feil, J. Felfoldine, Kis, E., Kosztyu, M., Kanakaridisz, N., Varga, A., Fiok, J., Szatmari, J., Edes, I., Muskoczki, E., Dioszeghy, P., Almaraz, S. Padilla, Camas, L. Velasquez, Guerra, L., Samayoa, C. Sanchez, Pozuelos, J. Mayen, Sanchez, M., Estrada, M. Rodas, Guevara, S., Lavagnino, A. Ovando, Jimenez, T., Melgar, I. Guzman, Ramirez, V. de Leon, Milla, O. Ayau, Korantanis, K., Pyrgakis, V., Kartsagkoulis, E., Olympios, C., Dimitra, K., Moschos, N., Daskalaki, A., Kifnidis, K., Exarchou, E., Karamitsos, C., Tziortziotis, A., Bourlios, P., Mavronasiou, E., Alexopoulos, D., Winter, K., Wolde, C., Buelow-Johansen, B., Winkelmann, B., Weyland, K., Buchholz, M., Voehringer, Voehringer, Ludwig, I., Veltkamp, R., Zarpentin, C., Taggeselle, J., Stoehring, R., Bonin, K., Spitzer, S., Baylacher, M., Sohn, H., Gold, G., Hellmers, J., Schreckenberg, A., Schmidt, M., Schmidt, A., Schiewe, C., Dreykluft, K., Finsterbusch, T., Schenkenberger, I., Frommhold, R., Schellong, S., Szymanowski, N., Schaefer, A., Kuehlenborg, A., Rinke, A., Pilipenko, H., Rack, K., Kuhlmann, M., Proskynitopoulos, N., Pohl, W., Lewinsky, D., Piechatzek, R., Raddatz, K., Mueller-Glamann, M., Barbera, S., Muegge, A., Vogt, S., Mitrovic, V., Frahm, E., Meyer-Pannwitt, U., Braemer, U., Meissner, G., Hoefer, K., Maus, O., Wulf, M., Luttermann, M., Venneklaas, U., Lueders, S., Grosse, B., Lohrbaecher-Kozak, I., Bauch, F., Koenig, H., Meusel, P., Kleinecke-Pohl, U., Schoen, B., Jungmair, W., Schmid, S., Junggeburth, J., Fink, P., Horacek, T., Schuppe, M., Hoffmann, S., Dorn, S., Hoffmann, U., Bobbie, C., Dieckheuer, U., Heuer, H., Peitz, M., Hartmann, A., Otto, A., Grigat, C., Manuela, W., Fuchs, R., Schneider, K., Forck-Boedeker, K., Faghih, M., Herfurth, B., Drescher, T., Kranz, P., Degtyareva, E., Ayasse, D., Daut, W., Kara, M., Contzen, C., Weihrauch, D., Buhr, M., Ladenburger, K., Braun, R., Schnelzer, P., You, Z. 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- Published
- 2016
9. Stroke and Mortality Risk in Patients With Various Patterns of Atrial Fibrillation: Results From the ENGAGE AF-TIMI 48 Trial (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48)
- Author
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Jones, D., Gu, X. J., Liu, L., Grammer, M., Waseem, M., Roper, E., Harden, M., Zellner, C., Mason, T., Zeig, S., Curtis, S., Zakhary, B., Yousuf, K., Wharton, S., VonGerichten, S., Willis, J., Dowling, C., Williams, R., Gibson, C., Williams, D., Truva, C., Westcott, J., St Laurent, B., Weiss, R., Sanchez, G., Waxman, F., Locklear, T., Ward, S., Renaud, K., Walsh, R., Kilcup, S., Vossler, M., Washam, M., Vijay, N., Warren, K., Vicari, R., Parsons, T., Verma, S., Cardoza, T., Vemireddy, D., Harrelson, K. 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J., Sand, N., Raae, D., Raymond, I., Petrovic, V., Overgaard, K., Olsen, R., Nielsen, H., Veng-Olsen, T., Talajic, M., Iversen, H., Madsen, H., Ibsen, H., Loof, A., Hassager, C., Christensen, L., Christensen, H., Dodt, K., Zidkova, E., Samkova, D., Vodnansky, P., Labrova, R., Spinar, J., Spacek, R., Slaby, J., Reichert, P., Jirsova, E., Podrazil, P., Pisova, J., Havlova, I., Petrova, I., Peterka, K., Olsr, J., Nechanicky, R., Melichar, M., Krocova, E., Machova, V., Ludka, O., Kvasnicka, J., Kuchar, R., Kovar, P., Kosek, Z., Kostkova, G., Kochrt, M., Kobza, R., Jirmar, R., Jerabek, O., Jelinek, Z., Jarkovsky, P., Jandik, J., Hubac, J., Honkova, M., Gregor, P., Campisto, Y., Morissette, A., Sussman, J., Gao, M., Frahm, E., Golan, L., Mitrovic, V., Zheng, Y., Zapata Staub, J., Zheng, X., Francek, L., Florian, J., Ferkl, R., Elbl, L., Cermak, O., Burianova, H., Brtko, M., Kailey, P., Retamal Matus, L., Fonseca, J., Han, R. J., Velthuysen, G., Bugueno, C., Orozco Linares, L., Bobbie, C., Heath, J., Lopez Giraldo, D., Raddatz, K., Zhao, X. L., Voehringer, Voehringer, Scott, L., Ho, K., Ho, V., Chen, X. P., Car, S., Hoag, G., Bolton, R., O'Mahony, W., Banville, P., O'Hara, G., Nicholson, R., Lamoureux, U., Kunkelova, V., Najarali, A., Mucha, M., Roth, M., Morrison, D., Morely, A., Mawji, A., Studenikow, E., Maranda, C., Vaillancourt, T., Zhang, X., Dong, Y. G., Standring, R., Feng, C., Fu, G. S., Wang, J. Q., Beeton, I., Dunn, S., Blagden, M., Price, R., Camm, J., Dougal, K., Mondaca Mondaca, P., Chapman, O., Davies, D., Choy, A., Duff, J., Zheng, Z. Q., Wilmott, R., D'Costa, D., Douglas, H., Lie, F., Ramasamy, V., Lindsay, S., Atkinson, C., Moncada Corredor, M., Linker, N., Finlayson, M., Lip, G., Brown, R., MacCallum, P., Ebano, P., MacLeod, M., McGhee, C., Marazzi, P., Maxwell, T., Isted, C., More, R., Helliwell, L., Murdoch, D., Andrews, A., Newby, D., Flint, L., Pye, M., Wright, L., Avery, D., Senior, R., Young, G., Sopher, M., Kennard, S., Storey, R., Zhang, P., Bridge, C., Hong, K., Turner, W., Walker, M., Venkataraman, A., Gilchrist, M., Watkin, R., Chung, A., Wright, A., Wright, J., Cobos, J., Mueller-Glamann, M., Yang, Y. J., Jeric, M., Li, A. Y., Yang, K., Liang, Y. Z., Xu, Y. M., Gu, J. Y., Berka, L., Xu, J. H., You, Z. G., Li, Y. E., Syan, G., Hoefer, K., Rivera Rodriguez, E., Brodova, P., Ludwig, I., Obreque, C., Manzur, F., Builes, A., Hoffmann, U., Jaramillo Munoz, C., Dorn, S., Veltkamp, R., Hoffmann, S., Li, B. G., Potthoff, S., Bar, M., Vogt, S., Delgado, P., Zhou, S. X., Schuppe, M., Bergovec, M., Muegge, A., Teitelbaum, J., Barbera, S., Horacek, T., Torres Carrasco, G., Vrazic, H., Zhang, Y. L., Ciglenecki, N., Liao, D. N., Pincetti, C., Fink, P., Teitelbaum, I., Carmona Perez, M., Junggeburth, J., Liu, Y., Schmid, S., Li, Z. Q., Jungmair, W., Spitzer, S., Opazo, M., Lu, Z. H., Tusek, S., Ferri Certic, J., Romic, I., Francetic, I., Makar Ausperger, K., Jelic, V., Jaksic Jurinjak, S., Knezevic, A., Lichtenstein, T., Lam, H., Bakliza, Z., Sutalo, K., Lam, S., Romero Llamas, R., Ma, S. M., Huynh, T., St-Germain, L., Luton, R., Accini, J., Lainesse, A., Perkins, L., Douglas, S., Dewar, C., Ma, P., Kouz, S., Kirner, D., Steiner, R., Matthews, J., MacCallum, C., Cvitkusic Lukenda, K., Schoen, B., Kleinecke-Pohl, U., Meusel, P., Koenig, H., Bauch, F., Lohrbaecher-Kozak, I., Grosse, B., Lueders, S., Venneklaas, U., Luttermann, M., Wulf, M., Maus, O., Seib, M., Malette, P., Roberts, P., Yang, Z. Y., Roy, M., Labonte, R., Kong, Y. Q., Samardzic, P., Qu, Z., Hong, L., Buksa, B., Qiu, Y., Tremblay, M., Talbot, P., Accini, M., Hernandez, H., Wang, D. M., Qi, S. Y., Corbalan, R., Wang, G. P., Cano, N., Aldana Diaz, I., Shi, X. J., Martinez, D., Wu, S. L., Fernandez Ruiz, R., Manriquez Silva, L., Manriquez, L., Rebolledo, C., Wei, M., Leon Pineda, L., Arroyave, C., Lopetegui, M., Arratia Diaz, P., Huang, D., Florenzano, F., Parada, A., Bonin, K., Delgado Restrepo, J., Stoehring, R., Taggeselle, J., Zarpentin, C., Huikuri, Heikke, Puripun, E., Yarows, S., Giugliano, Robert P., Scirica, Benjamin M., Wood, K., Sheehan, T., Yasin, M., Worley, S., Ruff, Christian T., Link, Mark S., Pointer, S., Capasso-Gulve, E., Yi, J., Dongas, B., and Yalcin, R.
- Subjects
Male ,medicine.medical_specialty ,medicine.drug_mechanism_of_action ,Pyridines ,medicine.medical_treatment ,Factor Xa Inhibitor ,Hemorrhage ,030204 cardiovascular system & hematology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Edoxaban ,Risk Factors ,Physiology (medical) ,Internal medicine ,Thromboembolism ,Atrial Fibrillation ,Medicine ,Humans ,atrial fibrillation ,cardiovascular diseases ,030212 general & internal medicine ,Myocardial infarction ,Stroke ,Aged ,business.industry ,Warfarin ,Anticoagulants ,Atrial fibrillation ,Thrombolysis ,thromboembolism ,bleeding ,medicine.disease ,mortality ,stroke ,Thiazoles ,Treatment Outcome ,chemistry ,Anesthesia ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,TIMI ,medicine.drug ,Factor Xa Inhibitors - Abstract
Background— Whether the pattern of atrial fibrillation (AF) modifies the risk/benefit of anticoagulation is controversial. In ENGAGE AF-TIMI 48 trial (Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation–Thrombolysis in Myocardial Infarction 48), the factor Xa inhibitor edoxaban was noninferior to warfarin in preventing stroke or systemic embolic events and significantly reduced bleeding and cardiovascular mortality. However, detailed analyses by AF pattern have not been reported. Methods and Results— The 21 105 patients were categorized as having paroxysmal (P -adj =0.015) and permanent AF (1.95%/year; P -adj =0.004). Overall, all-cause mortality also was lower with paroxysmal (3.0%/year) compared with persistent (4.4%/year; P -adj P -adj Conclusions— In ENGAGE AF-TIMI 48 trial, patients with paroxysmal AF suffered fewer thromboembolic events and deaths compared with those with persistent and permanent AF. The efficacy and safety profile of edoxaban as compared with warfarin was consistent across the 3 patterns of AF. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00781391.
- Published
- 2016
10. Cerebrovascular events in 21 105 patients with atrial fibrillation randomized to edoxaban versus warfarin: Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48
- Author
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Dougal, K., Venkataraman, A., Murdoch, D., Blagden, M., Dunn, S., MacCallum, P., Young, G., Lip, G., Senior, R., Brown, R., Sopher, M., Ebano, P., Linker, N., Atkinson, C., Lindsay, S., MacLeod, M., More, R., Ramasamy, V., Chapman, O., Lie, F., Beeton, I., McGhee, C., Wilmott, R., Dickinson, D., Douglas, H., Davies, D., D'Costa, D., Finlayson, M., Wright, A., Avery, D., Wright, L., Pye, M., Marazzi, P., Flint, L., Newby, D., Kennard, S., Andrews, A., Storey, R., Helliwell, L., Bridge, C., Choy, A., Turner, W., Walker, M., Wright, J., Smith, S., Jones, D., Maxwell, T., Chung, A., Isted, C., Cohen, A., Camm, J., Price, R., Watkin, R., Gilchrist, M., Duff, J., Aggarwal, R., Eldred, R., Adler, P., Chehayeb, R., Vandekerckhove, Y., Gordon, L., Jones, S., Young, C., Coyle, G. Stagi, Ferguson, D., Lang, J., Simmons, T., Langevin, E., Faucett, S., Ledbetter, L., Royse, H., Lentz, M., Smith, D., Lesser, M., Hartley, L., Lewis, D., Bonds, C., Lillestol, M., Miller, D., Ling, L., Murphy, R., Littlefield, R., Wofford, E., Lomnitz, D., Shah, D., Lone, B., Davids, M., Looby, R., Ault, S., Lui, H., Wright, H., Lurie, M., Edelstein, J., Macomber, J., Bush, D., Magee, A., Doctor, A., Mainigi, S., Lisiecki, B., Makam, S., Casas, R., Mandviwala, M., Hernandez, S., Marar, I., Rabadi-Marar, D., Marenberg, M., Bedenko, E., Massin, E., Hicks, T., McCartney, M., Stubbs, L., McGarvey, J., Schwarz, L., McGuire, K., Miranda, J., McKenzie, M., Rodkey, K., McKnight, T., Paul, J., McLaurin, B., Lack, A., Mega, J., Marti, J., Meholick, A., Skinner, J., Mehrle, A., Wall, J., Mendelson, R., Cervellione, K., Mercado, A., Cajulis, C., Michlin, B., Romero-Colon, J., Milas, J., Sanders, D., Miller, R., Sanchez, S., Miller, S., Gryczan, J., Mody, F., Strugatsky, S., Moran, J., Garner, S., Morledge, J., Bowman, B., Mouhaffel, A., Parrott, N., Mounsey, P., Schuler, C., Mowdy, M., Todd, S., Mullen, P., Raziano, S., Murphy, A., Oehmann, V., Nadar, V., Parker, A., Naidu, J., West, M., Nallasivan, M., Goza, J., Nguyen, T., Nomanee, S., Nielsen, R., Wilmot, M., Oberoi, M., Thakkar, N., Oppenheimer, K., McCormick, J., Orchard, R., Garcia, L., Osborne, J., Gonzalez, M., Oza, S., Joseph, L., Patnam, S., Dennison, K., Pavon, H., Gorry, N., Pearlstein, R., Montayne, S., Pentz, W., Duncan, D., Peters, P., Chacon, L., Petruzziello, F., Morlando, F., Pettis, K., Brown, F., Pezzella, S., Kirk, D., Poulathas, A., Cush, S., Pratt, R., Neeper, L., Pribble, A., Lowe, K., Pudi, K., Sham, L., Pugeda, J., Ebert, J., Quadrel, M., Rafla, E., Quinlan, E., Reed, C., Quinn, J., Hemmen, C., Rama, P., Domingo, D., Redondo, V., Wroblewski, J., Renzi, M., Stanley, E., Richwine, R., Pazier, P., Roberts, J., Riofrio, K., Braun, D., Robinson, J., Cherrico, M., Roehll, W., Hollihan, P., Rosado, J., Barnhorst, M., Rosen, R., Martin, C., Ross, S., Freeman, R., Ruoff, G., Nelson, T., Sacco, J., Ball, E., Samal, A., Schomburg, J., Sandberg, J., Lafave, J., Savin, V., Clifton, R., Schaefer, S., Fekete, A., Schneider, R., Schneider, W., Schulman, D., Mercer, S., Seals, A., Ullig, T., Holt, A., Seide, H., Mather, N., Shah, G., Witt, P., Shalaby, A., Seese, M., Shanes, J., Fleets, J., Shaoulian, E., Hren, A., Sheikh, K., Hengerer, T., Shih, H., Browning, J., Shoukfeh, M., Stephenson, L., Siler, T., Champagne, M., Simpson, P., Meyer, R., Singh, N., Turner, K., Singh, V., Nelson, M., Skierka, R., Hughes, B., Keene, R., Smith, R., Hodnett, P., Spangenthal, S., Thomason, L., Sperling, M., Vasquez, E., Spivack, E., McCartney, P., Staniloae, C., Liu, M., Steljes, A., Cox, C., Struble, R., Vittitow, T., Suresh, D., Frost, J., Swerchowsky, V., Freemyer, D., Szulawski, I., Herwehe, S., Tahirkheli, N., Springer, K., Takata, T., Bruton, T., Talano, J., Leo, L., Tami, L., Corchado, D., Tatarko, M., Swauger, M., Tawney, K., Dastoli, K., Teague, S., Young, K., Tee, H., Mitchell, T., Teixeira, J., Southam, D., Torres, M., Romero, N., Tucker, P., Salas, L., Updegrove, J., Hanna, K., Val-Mejias, J., Harrelson, K. 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Vogelmann, O., Braunwald, Eugene, Antman, Elliott M., Mercuri, Michele, Shi, Minggao, Dave, Jay, Duggal, Anil, Betcher, Joshua M., Grip, Laura T., Murphy, Sabina A., Deenadayalu, Naveen, Lowe, Cheryl, Wiviott, Stephen D., Silverman, Scott, Gowda, S., Rafala, E., Graham, S., Bonora, M., Griffin, S., Aull, L., Griffin, J., Goodman, V., Grossman, C., Davis, A., Grove, D., Mabe, K., Guarino, J., Gabela, W., Guarnieri, T., Guerrero, Guerrero, Foster, B., Guthrie, R., Felsman, D., Gvora, T., McLean, R., Rost, Natalia S., Hack, T., Morelli, L., Hamroff, G., Bentivenga, L., Han, M., Cavanna, L., Harris, J., Bobade, M., Hearne, S., Krater, C., Heiman, M., Dandekar, U., Henderson, D., Millard, D., Henry, S., Harkins, V., Hermany, P., Batchell, K., Herrod, J., Miranda, D., Herson, S., Carey, G., Hinchman, D., Vieira, P., Hippert, R., Dutter, S., Hoekstra, J., Homan, J., Homayouni, A., Horton, K., Sloss, D., Hotchkiss, D., Turner, N., Houchin, V., Adams, K., Howard, V., Hays, D., Howard, L., 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Padinhare, Angel, J., Gurusamy, P., Oomaan, A., Natarajan, S., Narendra, J., Shelke, S., Namjoshi, D., Francis, V., Menon, J., Sharma, P., Mathur, A., Bhaskarwar, P., Mardikar, H., Kale, M., Lavhe, P., Anthony, A., Kumbla, M., Francis, J., Kumar, A., Karpuram, M., Kumar, P., Lawande, A., Kulkarni, G., Deokar, M., Kulkarni, R., Kotiwale, V., Krishnan, H., Kishore, R., Kandekar, S., Kandekar, B., Raut, N., Kale, V., Joshi, H., Thomas, R., Joseph, J., Oommen, D., Joseph, S., Pahuja, M., Jain, R., Ghume, A., Hiremath, J., Thakor, G., Hardas, S., Savanth, P., Hadan, S., Singh, P., Gupta, J., Saini, A., Goyal, N., Mali, N., Chopda, M., Karnwal, N., Somaraju, B., Calambur, N., Bhuti, M., Biniwale, A., Rathi, A., Bhargava, V., Solanki, R., Bharani, A., Surushe, S., Benjarge, P., Sheth, T., Banker, D., Reddy, J., Babu, R., Rao, B., Babu, P., Shaikh, A., Avvaru, G., Shree, R., Arora, V., Memon, A., Arneja, J., Ranka, R., Agarwal, D., Abdullakutty, J., Malhan, S., Kincses, M., Vertes, A., Marosi, A., Tomcsanyi, J., Szakal, I., Sipos, T., Ruzsa, D., Simor, T., Bognar, A., Sayour, A., Toth, S. 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Ayau, Korantanis, K., Pyrgakis, V., Kartsagkoulis, E., Olympios, C., Dimitra, K., Moschos, N., Daskalaki, A., Kifnidis, K., Exarchou, E., Karamitsos, C., Tziortziotis, A., Bourlios, P., Mavronasiou, E., Alexopoulos, D., Winter, K., Wolde, C., Buelow-Johansen, B., Winkelmann, B., Weyland, K., Buchholz, M., Voehringer, Voehringer, Ludwig, I., Veltkamp, R., Zarpentin, C., Taggeselle, J., Stoehring, R., Bonin, K., Spitzer, S., Baylacher, M., Sohn, H., Gold, G., Seibert, H., Hellmers, J., Schreckenberg, A., Schmidt, M., Schmidt, A., Schiewe, C., Dreykluft, K., Ellis, J., Cristaldi, J., Finsterbusch, T., Erenrich, N., Schenkenberger, I., Frommhold, R., Schellong, S., Szymanowski, N., Schaefer, A., Kuehlenborg, A., Rinke, A., Pilipenko, H., Rack, K., Kuhlmann, M., Proskynitopoulos, N., Pohl, W., Lewinsky, D., Piechatzek, R., Raddatz, K., Mueller-Glamann, M., Barbera, S., Muegge, A., Vogt, S., Mitrovic, V., Frahm, E., Meyer-Pannwitt, U., Braemer, U., Meissner, G., Hoefer, K., Maus, O., Wulf, M., Luttermann, M., Venneklaas, U., Lueders, S., Grosse, B., Lohrbaecher-Kozak, I., Bauch, F., Koenig, H., Meusel, P., Kleinecke-Pohl, U., Schoen, B., Jungmair, W., Schmid, S., Junggeburth, J., Fink, P., Horacek, T., Schuppe, M., Hoffmann, S., Dorn, S., Hoffmann, U., Dieckheuer, U., Heuer, H., Peitz, M., Hartmann, A., Otto, A., Grigat, C., Manuela, W., Fuchs, R., Schneider, K., Forck-Boedeker, K., Faghih, M., Herfurth, B., Drescher, T., Kranz, P., Degtyareva, E., Ayasse, D., Daut, W., Kara, M., Contzen, C., Weihrauch, D., Buhr, M., Ladenburger, K., Braun, R., Schnelzer, P., Bouzo, M., Sehr, B., Beyer-Westendorf, J., Vierbeck, S., Berrouschot, J., Dichristin, U., Bernhardt, P., Wurow, A., Al-Zoebi, A., Duprat, C., Roudaut, R., Leparree, S., Poulard, J., Corbut, S., Kacet, S., Deruche, E., Hermida, J., Arfaoui, M., Dinanian, S., El Jarroudi, M., Decoulx, E., Berger, N., Coisne, D., Dias, P., Blanc, J., Berbari, H., Belhassane, A., Boyer, M., Babuty, D., Boursin, P., Amarenco, P., El Jarroudi, F., Agraou, B., Le Heuzey, J., Nappila, H., Virtanen, V., Salminen, O., Rasi, H., Sankari, T., Nyman, K., Viitaniemi, J., Maenpaa, A., Laheaar, M., Lucijanic, T., Lappalainen, T., Jakala, P., Valpas, S., Hussi, E., Kaarleenkaski, S., Huikuri, H., Ratnik, E., Vahula, V., Rajasalu, R., Rosenthal, A., Voitk, J., Paumets, M., Rivis, L., Laane, E., Kolk, R., Stern, A., Kaik, J., Serup-Hansen, K., Wiggers, H., Jakobsen, U., Torp-Pedersen, C., Svenningsen, A., Sand, N., Raae, D., Raymond, I., Petrovic, V., Overgaard, K., Olsen, R., Nielsen, H., Veng-Olsen, T., Iversen, H., Madsen, H., Ibsen, H., Loof, A., Hassager, C., Christensen, L., Christensen, H., Dodt, K., Zidkova, E., Samkova, D., Vodnansky, P., Labrova, R., Spinar, J., Johnson, C., Spacek, R., Slaby, J., Reichert, P., Jirsova, E., Podrazil, P., Pisova, J., Havlova, I., Petrova, I., Peterka, K., Olsr, J., Nechanicky, R., Melichar, M., Krocova, E., Machova, V., Ludka, O., Kvasnicka, J., Kuchar, R., Kovar, P., Kosek, Z., Kostkova, G., Kochrt, M., Kobza, R., Jirmar, R., Jerabek, O., Jelinek, Z., Jarkovsky, P., Jandik, J., Hubac, J., Honkova, M., Gregor, P., Golan, L., Francek, L., Florian, J., Ferkl, R., Elbl, L., Cermak, O., O'Brien, J., Burianova, H., Brtko, M., Kunkelova, V., Berka, L., Brodova, P., Bar, M., Bergovec, M., Vrazic, H., Bakliza, Z., Sutalo, K., Kirner, D., Steiner, R., Cvitkusic Lukenda, K., Samardzic, P., Buksa, B., Knezevic, A., Jaksic Jurinjak, S., Ettinger, N., Shipp, A., Jelic, V., Makar Ausperger, K., Francetic, I., Romic, I., Ferri Certic, J., Tusek, S., Ciglenecki, N., Jeric, M., Car, S., Carevic, V., Bagatin, J., Perdomo Mejia, I., Sanchez Vallejo, G., Gonzales, C., Quintero, A., Fonseca, J., Orozco Linares, L., Lopez Giraldo, D., Moncada Corredor, M., Rivera Rodriguez, E., Manzur, F., Builes, A., Jaramillo Munoz, C., Delgado, P., Hernandez, H., Aldana Diaz, I., Fernandez Ruiz, R., Arroyave, C., Delgado Restrepo, J., Leon Pineda, L., Cano, N., Accini, M., Accini, J., Zhang, Y. L., Zhou, S. X., Li, B. G., Zheng, Z. Q., Wang, J. Q., Zhao, X. L., Han, R. J., Zhao, R. P., Kang, H., Zhang, Z., Lin, Y. N., Zhang, H. Q., Qiang, H., Everhart, B., DeSalle, D., Fahmy, R., Watkins, D., Yuan, Z. Y., Li, L. L., Yu, B., Xu, Y. P., Yin, Y. H., Gao, M., Zheng, Y., Feld, L., Zheng, X., Tameron, A., Feldman, J., Tang, N., Felten, W., Yang, Y. J., Li, A. Y., Yang, K., Liang, Y. Z., Xu, Y. M., Gu, J. Y., Xu, J. H., Li, Y. E., Wu, S. L., Huang, D., Wei, M., Shi, X. J., Wang, G. P., Qi, S. Y., Wang, D. M., Yang, Z. Y., Ma, S. M., Lu, Z. H., Liu, L., Gu, X. J., Liao, D. N., Liu, Y., Prior, J., Fialkow, J., Calvo, M., Li, Z. Q., Liu, B., Finkel, M., Shriver, D., Finkelstein, S., Fischell, T., Drew, B., Fishbein, G., Donahue, S., Flores, E., Slayton, C., Forman, S., Solis, A., Frais, M., Thrope, C., Franco, M., Gentry, P., French, W., Morales, C., Friedlander, I., Smith, K., Gaffney, M., Jones, J., Li, W. M., Kong, Y. Q., Li, T. F., Liu, H., Li, L., Qu, Z., Jiang, X. J., Qiu, Y., Hong, L., You, Z. G., Hong, K., Zhang, P., Fu, G. S., Feng, C., Dong, Y. G., Zhang, X., Chen, X. P., Xie, X. D., Chen, J. Z., Xu, G. L., Bai, F., Grandon Azua, M., Yovaniniz, P., Lara Lara, C., Stockins, B., Campisto, Y., Zapata Staub, J., Potthoff, S., Torres Carrasco, G., Pincetti, C., Carmona Perez, M., Opazo, M., Romero Llamas, R., Martinez, D., Manriquez Silva, L., Manriquez, L., Rebolledo, C., Lopetegui, M., Arratia Diaz, P., Florenzano, F., Parada, A., Corbalan, R., Obreque, C., Cobos, J., Mondaca Mondaca, P., Bugueno, C., Retamal Matus, L., Balboa, W., Mabee, J., Woodford, T., Caterini, T., Wharton, S., Morley, A., Wahby, R., Giesbrecht, L., Velthuysen, G., Teitelbaum, J., Teitelbaum, I., Tremblay, M., Talbot, P., David, D., Talajic, M., Bobbie, C., Syan, G., Kailey, P., Sussman, J., Morissette, A., St-Hilaire, R., Silverio, G., Shu, D., Marchand, C., Rupka, D., Bozek, B., Ricci, J., Nethercott, C., Qureshi, A., Turri, L., Polasek, P., Sardin, V., Pesant, Y., Carroll, L., Parkash, R., Bolton, R., O'Mahony, W., Banville, P., O'Hara, G., Nicholson, R., Lamoureux, U., Garb, J., Najarali, A., Krider, J., Mucha, M., Roth, M., Morrison, D., Morely, A., Mawji, A., Studenikow, E., Maranda, C., Vaillancourt, T., Malette, P., Matthews, J., MacCallum, C., Seib, M., Ma, P., Douglas, S., Luton, R., Roberts, P., Lichtenstein, T., Lam, H., Lam, S., St-Germain, L., Lainesse, A., Dewar, C., Labonte, R., Roy, M., Kouz, S., Perkins, L., Huynh, T., Standring, R., Hoag, G., Ho, V., Ho, K., Scott, L., Heath, J., Hatheway, R., Houbraken, D., Viau, C., Fortin, C., Zondag, M., Eikelboom, J., Dufresne, M., Kubanska, A., du Preez, M., Denis, I., Coutu, B., Masson, C., Costi, P., Gauthier, M., Constance, C., Valley, S., Cleveland, D., Vansickle, L., Chilvers, M., Lepage, C., Otis, J., Cha, J., Hundseth, M., Bose, S., Stafford, C., Bhargava, R., Antle, S., Archibald, J., Manoylov, E., Kitova, M., Tzekova, M., Tumbeva, D., Tumbev, H., Nyagina, M., Todorov, G., Momchilova-Lozeva, D., Staneva, A., Vasilev, I., Popov, A., Milusheva, T., Petranov, S., Kostov, K., Pencheva, G., Vasilev, D., Nikolov, F., Stoyanovski, V., Mincheva, V., Miteva, B., Mihov, A., Manolova, A., Kamenova, P., Hergeldjieva, V., Kinova, E., Goudev, A., Kostova, E., Georgiev, B., Gergova, V., Donova, T., Milcheva, N., Denchev, S., Parishev, G., Chompalova, B., Zimmermann, E. Burger, Zimmermann, S., Almeida, M., Boas, F. Villas, Lustosa, E., Sobral Filho, D., Carraro, A., Simoes, M., Vicente, C., Saraiva, J., do Val, R., Sampaio, R., Pagnan, L. Goncalves, dos Santos, F. Rossi, Rodrigues, D., Rodrigues, A., Rocha, M. Rubia, Rodrigues, L., Barros, R., Rocha, J., Leipelt, J., Katz Weiand, L. Reis, Avellar, K., Reis, G., Gozalo, A., Almeida, J. Pimenta, Luiz, R. Osorio, Leaes, P., Morales, K., Sebba Barroso de Souza, W. Kunz, Radaelli, G., Kalil, C., Almeida, A., Kaiser, S., Cury, C., Jorge, J., Pereira, L., Jaeger, C., Ninho, L., Guimaraes, A., Gomes, A., Gomes, M., Pereira, G., Gagliardi, R., Daitz, C., Finimundi, H., Araujo, E., Ferreira, L., Seroqui, M., Saporito, W. Faustino, Morgado, S., Dutra, O., Laimer, R., Duda, N., Pereira, V., De Patta, M., Barroso, D., Costantini, C., Silva, J., Chaves Junior, H., Fleck, N., Brondani, R., Cunha, S., Botelho, R., Sehnem, E., Precoma, D. Bertolim, Ferraz, R. Franchin, Alves da Costa, F. Augusto, Motta, C., Atie, J., de Melo, R. Ferreira, Lotufo, P. Andrade, Coutinho, E., Vincenzo de Paola, A. Amato, Denie, D., and Wollaert, B.
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Male ,medicine.medical_specialty ,medicine.drug_mechanism_of_action ,medicine.drug_class ,Pyridines ,Factor Xa Inhibitor ,Infarction ,chemistry.chemical_compound ,Double-Blind Method ,Edoxaban ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,Myocardial infarction ,cardiovascular diseases ,Stroke ,Aged ,Advanced and Specialized Nursing ,Dose-Response Relationship, Drug ,business.industry ,Anticoagulant ,Warfarin ,Anticoagulants ,Atrial fibrillation ,Middle Aged ,medicine.disease ,Thiazoles ,Treatment Outcome ,chemistry ,Anesthesia ,Cardiology ,Female ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
Background and Purpose— The once-daily oral factor Xa inhibitor, edoxaban, is as effective as warfarin in preventing stroke and systemic embolism while decreasing bleeding in a phase III trial of patients with atrial fibrillation at moderate–high stroke risk. Limited data regarding cerebrovascular events with edoxaban were reported previously. Methods— We analyzed the subtypes of cerebrovascular events in 21 105 patients participating in Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48 (ENGAGE AF-TIMI 48) comparing outcomes among patients randomized to warfarin versus 2 edoxaban regimens (high dose, low dose). The primary end point for this prespecified analysis of cerebrovascular events was all stroke (ischemic plus hemorrhagic), defined as an abrupt onset of focal neurological deficit because of infarction or bleeding with symptoms lasting ≥24 hours or fatal in Results— Patients randomized to high-dose edoxaban had fewer strokes on-treatment (hazard ratio, 0.80; 95% confidence interval, 0.65–0.98) than warfarin (median time-in-therapeutic range, 68.4%); patients in the low-dose edoxaban group had similar rates (hazard ratio, 1.10 versus warfarin; 95% confidence interval, 0.91–1.32). Rates of ischemic stroke or transient ischemic attack were similar with high-dose edoxaban (1.76% per year) and warfarin (1.73% per year; P =0.81), but more frequent with low-dose edoxaban (2.48% per year; P Conclusions— In patients with atrial fibrillation, once-daily edoxaban was as effective as warfarin in preventing all strokes, with significant reductions in various subtypes of intracranial bleeding. Ischemic cerebrovascular event rates were similar with high-dose edoxaban and warfarin, whereas low-dose edoxaban was less effective than warfarin. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00781391.
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- 2014
11. 1066P - A phase II trial of docetaxel plus cisplatin in recurrent and/or metastatic non-squamous cell carcinoma of head and neck
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Imamura, Y., Kiyota, N., Tanaka, K., Hayashi, H., Ota, I., Nario, K., Hirano, S., Arai, A., Iwae, S., Onoe, T., Minami, S., Shimada, T., Yane, K., Yamazaki, T., Nagatani, Y., Toyoda, M., Otsuki, N., Nibu, K.-I., and Minami, H.
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- 2018
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12. Cardiac mechanical and electrophysiologic modulations of guinea pig by caffeine and thapsigargin
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Nario, K. and Satoh, H.
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- 1996
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13. Neurovascular compression syndrome with Meniere's disease - a report of the treatment of a patient with microvascular decompression
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Fujita, N., Nario, K., Yamanaka, T., Ueda, T., and Matsunaga, T.
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- 1998
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14. The effect of protein kinase C stimulator and inhibitor on cochlear potentials in the guinea pig
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Kitano, I., Nario, K., Mori, N., and Matsunaga, T.
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- 1995
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15. Combination of head-up sleep and vertical recognition training may cure intractable motion-evoked dizziness with unknown origin.
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Kitahara T, Horinaka A, Shiozaki T, Ito T, Wada Y, Yamanaka T, and Nario K
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- Adult, Aged, Benign Paroxysmal Positional Vertigo diagnosis, Benign Paroxysmal Positional Vertigo etiology, Dizziness diagnosis, Dizziness etiology, Female, Humans, Male, Middle Aged, Patient Positioning, Treatment Outcome, Benign Paroxysmal Positional Vertigo therapy, Dizziness therapy, Head, Head Movements, Posture, Sleep
- Abstract
Background: It has been reported that head-up sleep (HUS) prevents free-floating otoliths from entering canals and that vertical recognition training (VRT) promotes vestibular compensation. Aims/objectives: We would like to assess HUS and VRT for intractable motion-evoked dizziness, including possible benign paroxysmal positional vertigo (BPPV). Materials and methods: 162 patients diagnosed with intractable motion-evoked dizziness of unknown origin were enrolled and randomly divided into the following four groups: HUS-/VRT-, HUS+/VRT-, HUS-/VRT+, and HUS+/VRT+. The at-home interventions comprised HUS with an upper head position of 45° when lying down and VRT with a right down-left down 30° head inclination while watching the vertical index. Results: At the post-treatment 6th month, visual analogue scale (VAS) scores for vertiginous sensation were significantly lower in the HUS+/VRT + group than in the HUS+/VRT - and HUS-/VRT + groups, which were in turn significantly lower than those in the HUS-/VRT - group. VAS scores in the HUS-/VRT + group of patients with abnormal subjective visual vertical (SVV) were significantly lower than those in the HUS+/VRT - group, while those in the HUS+/VRT - group of patients with normal SVV were significantly lower than those in the HUS-/VRT + group. Conclusions: HUS and/or VRT is a good initial treatment for patients with intractable undiagnosed motion-evoked dizziness, including possible BPPV.
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- 2020
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16. Head-Up Sleep May Cure Patients With Intractable Benign Paroxysmal Positional Vertigo: A six-Month Randomized Trial.
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Horinaka A, Kitahara T, Shiozaki T, Ito T, Wada Y, Yamanaka T, and Nario K
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Objectives: The aim of the present study was to assess head-position management for intractable idiopathic benign paroxysmal positional vertigo (BPPV) when lying down. We hypothesized that head-up sleep (HUS) could prevent free-floating otoliths from entering the semicircular canals., Study Design: A prospective two-arm multicenter randomized controlled trial., Methods: BPPV was diagnosed in 611 patients (611/1,520; 40.2%) according to the 2015 diagnostic guidelines issued by the International Classification of Vestibular Disorders. Among them, 201 patients were intractable (201/611; 32.9%), 88 of whom were idiopathic and subsequently enrolled in the study. Patients randomly received intervention with HUS at greater than 45° (n = 44) or head-down sleep (HDS; n = 44) when lying down. Before treatment, they completed several examinations, including subjective visual vertical (SVV). The specific diagnoses for the 88 patients with BPPV included horizontal type cupula (n = 40), horizontal type canal (n = 13), posterior type (n = 26), and probable and/or atypical BPPV (n = 9)., Results: Patient backgrounds did not differ significantly between the HUS and HDS groups. Visual analog scale (VAS) scores of vertiginous sensation were significantly lower in the HUS group than in the HDS group at both the third month and sixth month post-treatment. Positional/positioning nystagmus observed just before treatment disappeared significantly more often in the HUS group than in the HDS group until the sixth post-treatment month. Further, especially in HUS group, VAS scores in SVV- group (n = 24) were significantly lower than those in the SVV+ group (n = 20) sixth month post-treatment., Conclusions: Controlling free-floating otoliths is not easy due to aging of the otolith organs. Repeatedly returning the endless free-floating debris from the canals to the utricle through physical means is not a good strategy. Therefore, HUS when lying down at home could be recommended as an initial treatment for patients with intractable idiopathic BPPV., Level of Evidence: 1b.
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- 2019
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17. Effects of noise exposure on neonatal auditory brainstem response thresholds in pregnant guinea pigs at different gestational periods.
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Morimoto C, Nario K, Nishimura T, Shimokura R, Hosoi H, and Kitahara T
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- Acoustic Stimulation, Animals, Female, Gestational Age, Guinea Pigs, Male, Pregnancy, Evoked Potentials, Auditory, Brain Stem, Maternal Exposure adverse effects, Noise adverse effects
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Aim: Noise exposure during pregnancy has been reported to cause fetal hearing impairment. However, little is known about the effects of noise exposure during various gestational stages on postnatal hearing. In the present study, we investigated the effects of noise exposure on auditory brainstem response (ABR) at the early, mid-, and late gestational periods in newborn guinea pigs., Methods: Pregnant guinea pigs were exposed to 4-kHz pure tone at a 120-dB sound pressure level for 4 h. We divided the animals into four groups as follows: the control, early gestational exposure, mid-gestational exposure, and late gestational exposure groups. ABR thresholds and latencies in newborns were recorded using 1-, 2-, and 4-kHz tone burst on postnatal days 1, 7, 14, and 28. Changes in ABR thresholds and latencies were measured between the 4 × 4 and 4 × 3 factorial groups mentioned above (gestational periods × postnatal days, gestational periods × frequencies)., Results: The thresholds were low in the order of control group < early gestational exposure group < mid-gestational exposure group and late gestational exposure group. Noise exposure during pregnancy influenced ABR thresholds in neonatal guinea pigs., Conclusion: This is the first study to show that noise exposure during the early, mid-, and late gestational periods significantly elevated ABR thresholds in neonatal guinea pigs., (© 2016 Japan Society of Obstetrics and Gynecology.)
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- 2017
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18. Endolymphatic space size in patients with Meniere's disease and healthy controls.
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Ito T, Kitahara T, Inui H, Miyasaka T, Kichikawa K, Ota I, Nario K, Matsumura Y, and Yamanaka T
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- Adult, Aged, Aged, 80 and over, Case-Control Studies, Cochlea diagnostic imaging, Female, Humans, Injections, Intravenous, Male, Middle Aged, Vestibule, Labyrinth diagnostic imaging, Young Adult, Gadolinium, Magnetic Resonance Imaging, Meniere Disease diagnostic imaging
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Conclusions: The incident ratios of cochlear and/or vestibular endolymphatic hydrops (EH) were significantly higher in the affected ears of patients with Meniere's disease (MD) than in the ears of healthy controls. There were no significant differences between controls and the contralateral ears of MDs., Objectives: The aim was to compare the incidence ratios of EH between unilateral/bilateral MD and controls using 3T magnetic resonance imaging (MRI) with intravenous gadolinium., Methods: A total of 41 patients were diagnosed with MD: 32 with unilateral MD (uMD) and nine with bilateral MD (bMD). Fifteen healthy volunteers were enrolled as controls. The patients underwent 3T MRI 4 h after intravenous injection of gadolinium., Results: Cochlear EH was present in 3.3% of 30 ears of 15 controls, 6.3% of 32 contralateral (contra) ears of 32 uMDs, 62.5% of 32 affected ears of 32 uMDs, and 55.6% of 18 affected ears of nine bMDs. Vestibular EH was observed in 6.7% of control ears, 3.1% of contra-uMD ears, 65.6% of affected uMD ears, and in 55.6% of affected bMD ears. Either cochlear or vestibular EH was present in 10.0% of control ears, 6.3% of contra-uMD ears, 81.3% of affected uMD ears, and 44.4% of affected bMD ears.
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- 2016
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19. Chronic invasive sinus and intracerebral aspergillosis controlled by combination therapy with micafungin and a daily dose of 400 mg itraconazole oral solution.
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Ogawa T, Matsumoto K, Tsujimoto K, Hishiya N, Yamada Y, Uno K, Kasahara K, Maeda K, Nario K, Mikasa K, and Morita K
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- Aged, Aspergillosis microbiology, Aspergillosis pathology, Central Nervous System Fungal Infections diagnostic imaging, Central Nervous System Fungal Infections microbiology, Central Nervous System Fungal Infections pathology, Chronic Disease, Female, Humans, Micafungin, Paranasal Sinus Diseases microbiology, Paranasal Sinus Diseases pathology, Radiography, Antifungal Agents administration & dosage, Aspergillosis drug therapy, Central Nervous System Fungal Infections drug therapy, Echinocandins administration & dosage, Itraconazole administration & dosage, Lipopeptides administration & dosage, Paranasal Sinus Diseases drug therapy
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Chronic invasive aspergillosis of the sinus is frequently fatal in the absence of early surgical and chemotherapeutic intervention because of its invasion of vascular tissue. We attempted to control a case of inoperable invasive aspergillosis of the sinus with micafungin and itraconazole oral solution. We prescribed a daily oral dose of 400 mg of itraconazole, which is twice the usual dose, and monitored the serum concentration of the drug. Finally, we were able to control the spread of the lesion. This case indicates that combination therapy with micafungin and a daily dose of 400 mg itraconazole oral solution is an alternative treatment strategy for inoperable invasive aspergillosis of the sinus., (Copyright © 2014 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.)
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- 2015
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20. [Four cases of hypopharyngeal cancer treated with docetaxel, cisplatin, and 5-FU followed by radiotherapy and/or neck dissection].
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Miyahara H, Nario K, Matsushiro N, Sasai H, and Kajikawa H
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- Aged, Antineoplastic Combined Chemotherapy Protocols adverse effects, Chemotherapy, Adjuvant, Cisplatin administration & dosage, Cisplatin adverse effects, Docetaxel, Drug Administration Schedule, Fluorouracil administration & dosage, Fluorouracil adverse effects, Humans, Hypopharyngeal Neoplasms surgery, Leukopenia chemically induced, Male, Middle Aged, Neck Dissection, Neoadjuvant Therapy, Prognosis, Radiotherapy Dosage, Taxoids administration & dosage, Taxoids adverse effects, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Hypopharyngeal Neoplasms drug therapy, Hypopharyngeal Neoplasms radiotherapy
- Abstract
We treated 4 patients with hypopharyngeal cancer, each of whom had a complete response after 2 cycles of chemotherapy with docetaxel, cisplatin, and 5-FU followed by radiation and/or neck dissection. Twenty-one months to 2 years after this therapy, 3 patients had no recurrence and no metastasis with their laryngeal framework and function preserved. Chemotherapy including docetaxel, cisplatin, and 5-FU is a useful treatment for early head and neck cancer.
- Published
- 2004
21. [A case of neck metastasis from hypopharyngeal carcinoma successfully treated with TS-1].
- Author
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Kajikawa H, Nario K, and Miyahara H
- Subjects
- Carcinoma, Squamous Cell secondary, Carcinoma, Squamous Cell surgery, Drug Administration Schedule, Drug Combinations, Humans, Hypopharyngeal Neoplasms pathology, Hypopharyngeal Neoplasms surgery, Lymph Nodes drug effects, Lymphatic Metastasis, Male, Middle Aged, Neck, Antimetabolites, Antineoplastic therapeutic use, Carcinoma, Squamous Cell drug therapy, Hypopharyngeal Neoplasms drug therapy, Lymph Nodes pathology, Oxonic Acid therapeutic use, Pyridines therapeutic use, Tegafur therapeutic use
- Abstract
We report a case of hypopharyngeal carcinoma with recurrent neck metastasis. Preoperative chemoradiation and pharyngo-laryngo-esophagectomy with bilateral neck dissection was done as first-line therapy. Six months later, the carcinoma metastasized to the right paratracheal lymph node. Because of resistance to chemoradiation (CBDCA) as second-line therapy, we administered TS-1 for the treatment after 60 Gy radiation. The chemotherapy with TS-1 resulted in complete response by diagnostic imaging (CT). There was no sign of recurrence for 1 year after 5 courses of treatment. TS-1, which allows oral chemotherapy on an outpatient basis, would be a useful drug for treatment with radiotherapy in patients with advanced and/or recurrent head and neck cancer.
- Published
- 2004
22. Effects of intravenous administration of prostaglandin E(1) and lipo-prostaglandin E(1) on cochlear blood flow in guinea pigs.
- Author
-
Nishimura T, Nario K, and Hosoi H
- Subjects
- Alprostadil therapeutic use, Animals, Blood Pressure drug effects, Blood Pressure physiology, Carotid Artery, Common drug effects, Carotid Artery, Common physiopathology, Cochlea physiopathology, Disease Models, Animal, Dose-Response Relationship, Drug, Guinea Pigs, Hearing Loss, Sensorineural physiopathology, Infusions, Intravenous, Lipids therapeutic use, Regional Blood Flow drug effects, Regional Blood Flow physiology, Time Factors, Vasodilator Agents therapeutic use, Alprostadil administration & dosage, Alprostadil pharmacology, Cochlea blood supply, Cochlea drug effects, Hearing Loss, Sensorineural drug therapy, Lipids administration & dosage, Lipids pharmacology, Vasodilator Agents administration & dosage, Vasodilator Agents pharmacology
- Abstract
Prostaglandin E(1) (PGE(1)), a vasodilator and an inhibitor of platelet aggregation, has been used for the treatment of idiopathic sudden sensorineural hearing loss, despite the fact that its effectiveness has not been proven. Furthermore, it is rapidly metabolized in the lungs, which makes it difficult to use clinically. In an attempt to prevent this, PGE(1) was coated with a 0.2-microg lipid microsphere produced by beans; this was designated lipo-PGE(1). This coating protects PGE(1) from being rapidly metabolized. In this study, the effectiveness of the intravenous administration of lipo-PGE(1) was compared with that of PGE(1) by investigating the effects on systemic blood pressure (SBP) and cochlear blood flow (CBF) in guinea pigs with normal ears. The results of both drugs showed a dose-dependent decrease in SBP and the maintenance of CBF despite the decrease in SBP. However, no significant increase in CBF was observed for either drug. In comparing the effects of PGE(1) and lipo-PGE(1), no obvious differences in the effects on SBP and CBF were observed in this study.
- Published
- 2002
- Full Text
- View/download PDF
23. Effect of endoplasmic Ca2+-ATPase inhibitors on cochlear potentials in the guinea-pig.
- Author
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Nario K, Kitano I, Mori N, and Matsunaga T
- Subjects
- Animals, Cochlea physiology, Dose-Response Relationship, Drug, Enzyme Inhibitors pharmacology, Guinea Pigs, Indoles pharmacology, Membrane Potentials drug effects, Thapsigargin pharmacology, Calcium-Transporting ATPases antagonists & inhibitors, Cochlea drug effects
- Abstract
The effect of endoplasmic Ca2+-ATPase inhibitors on cochlear potentials was examined in the guinea-pig. Perilymphatic perfusion with thapsigargin (10[-6] M) produced a significant decrease in the amplitudes of cochlear microphonics, negative summating potential and compound action potential, and a significant prolongation of N1 latency with no change in the endocochlear potential. These changes were all dose dependent. Another endoplasmic Ca2+-ATPase inhibitor, cyclopiazonic acid (10[-5] M), produced the same effects as thapsigargin on cochlear potentials. These results suggest that endoplasmic Ca2+-ATPase inhibitors may have inhibitory functions on cochlear potentials.
- Published
- 1998
- Full Text
- View/download PDF
24. The effect of forskolin on the sound-evoked potentials in the guinea pig cochlea.
- Author
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Kitano I, Mori N, Nario K, Doi K, and Matsunaga T
- Subjects
- Animals, Cochlea physiology, Cochlear Microphonic Potentials physiology, Endolymphatic Hydrops etiology, Guinea Pigs, Ion Transport, Cochlea drug effects, Cochlear Microphonic Potentials drug effects, Colforsin pharmacology
- Abstract
The effect of forskolin (FSK) on cochlear sound-evoked potentials was examined in the guinea pig. The perfusion of the scala vestibuli (SV) with FSK (2 x 10(-4) M) produced a significant increase in the amplitude of negative summating potential (- SP) with no change in cochlear microphonics (CM) amplitude, and a significant decrease in the amplitude of compound action potential (CAP) with a significant prolongation of N1 latency and a 20 dB CAP threshold elevation. The results lead us to speculate that FSK-induced changes may be involved in the transient formation of endolymphatic hydrops.
- Published
- 1998
- Full Text
- View/download PDF
25. Inner ear blood flow in the rat after unilateral arterial occlusion in the vertebrobasilar arterial system.
- Author
-
Ueda T, Murai T, Nario K, Fujita N, Miyahara H, and Matsunaga T
- Subjects
- Animals, Arteries physiology, Cerebellum blood supply, Male, Rats, Rats, Wistar, Regional Blood Flow physiology, Cochlea blood supply, Semicircular Canals blood supply, Vertebral Artery physiology, Vertebrobasilar Insufficiency physiopathology
- Abstract
It is generally accepted that certain kinds of vertigo and hearing disturbances are caused by blood flow insufficiency in the vertebrobasilar arterial system. Using the microsphere method we investigated whether unilateral vertebral artery or unilateral posterior inferior cerebellar artery occlusion could cause an imbalance between right and left inner ear blood flow in rats. We also studied the differential vulnerability between blood flow in the cochlea and in the ampullae of the three semicircular canals. We counted the numbers of microspheres distributed to the cochlea (CO) and microspheres distributed to three ampullae of semicircular canals (SC) under a microscope with the surface preparation method. The results were as follows: i) no imbalances were observed between bilateral CO or SC even in animals with arterial occlusion, and ii) the CO/SCs of animals with arterial occlusion were not significantly different from that of the control animals. These findings suggest that total inner ear blood flow over a certain period of time was even between the ears bilaterally even in animals with arterial occlusion. The blood flow in the ampullae of the three semicircular canals was not more or less affected by arterial occlusion than the blood flow in the cochlea.
- Published
- 1998
26. Effect of intravenous vasopressin on endocochlear potential and systemic blood pressure in the guinea pig.
- Author
-
Nario K, Ueda T, Murai T, Miyahara H, and Matsunaga T
- Subjects
- Animals, Arginine Vasopressin administration & dosage, Arginine Vasopressin physiology, Blood Pressure physiology, Cochlear Microphonic Potentials physiology, Guinea Pigs, Infusions, Intravenous, Vasoconstrictor Agents administration & dosage, Arginine Vasopressin pharmacology, Blood Pressure drug effects, Cochlear Microphonic Potentials drug effects, Vasoconstrictor Agents pharmacology
- Abstract
The effects of intravenous arginine-vasopressin (AVP) on the endocochlear potential (EP) and systemic blood pressure (BP) were examined in the guinea pig. Intravenous AVP (10(-7) M) elevated BP significantly but did not change EP. AVP (10(-8) M) produced a significant decrease in the amplitude of EP but did not change mean blood pressure significantly. AVP at 10(-9) M did not affect EP or BP. These results suggest that intravenous AVP might have an inhibitory effect on EP.
- Published
- 1998
27. Failure of forskolin to elevate the endocochlear potential in experimental endolymphatic hydrops of the guinea pig.
- Author
-
Kitano I, Mori N, Nario K, Umemoto M, Sakagami M, Fukazawa K, and Matsunaga T
- Subjects
- Animals, Cochlea drug effects, Cochlea physiology, Cochlear Duct drug effects, Cochlear Duct physiology, Cochlear Microphonic Potentials physiology, Guinea Pigs, Ion Transport drug effects, Cochlear Microphonic Potentials drug effects, Colforsin pharmacology, Endolymphatic Hydrops physiopathology
- Abstract
The effect of forskolin (FSK) on the endocochlear potential (EP) in scala media (SM) was examined in experimental endolymphatic hydrops of the guinea pig. Two weeks after obliteration of the endolymphatic sac the EP of hydroptic ears and that of the contralateral control ears were measured by means of microelectrodes. The perfusion of scala vestibuli (SV) with FSK (200 microM) produced EP elevation in the contralateral control ears but failed to do so in the experimental hydroptic ears. Histological examination of experimental endolymphatic hydrops showed mild hydrops with intact appearance of outer and inner hair cells, and the stria vascularis. The mechanism underlying the failure of FSK to elevate the EP in experimental endolymphatic hydrops is discussed.
- Published
- 1998
- Full Text
- View/download PDF
28. ABR findings, electrocochleograms and caloric tests in vertebrobasilar ischemic rats.
- Author
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Nario K, Matsunaga T, Inui H, Murai T, and Miyahara H
- Subjects
- Action Potentials physiology, Animals, Arteries, Cerebellum blood supply, Hearing physiology, Male, Nystagmus, Physiologic, Rats, Rats, Wistar, Regional Blood Flow physiology, Semicircular Canals blood supply, Semicircular Canals physiopathology, Audiometry, Evoked Response, Caloric Tests, Cochlea blood supply, Evoked Potentials, Auditory, Brain Stem physiology, Ischemia physiopathology, Vertebrobasilar Insufficiency physiopathology
- Abstract
In rats with ischemia induced by occlusion of the anterior inferior cerebellar artery (AICA) or vertebral artery (VA), we investigated the auditory brainstem response (ABR), electrocochleogram and caloric test result. Upon occlusion of the VA, there was no change of the ABR, whereas in the caloric test the duration of nystagmus upon stimulation of both ears shortened. Upon occlusion of the AICA, the cochlear blood flow (CoBF) showed one of three patterns of change no change: n = 5; decrease: n = 10; and transient decrease with recovery: n = 5. The cochlear potentials were dependent on the residual CoBF. In the caloric test, when the left AICA was occluded, the duration of nystagmus induced by stimulation of the left (ipsilateral) ear was shorter than that induced by the right (contralateral) ear. Based on the functional test results, we conclude that in this model of ischemia the function of the vestibular structures including the semicircular canals is more severely affected than is the hearing function.
- Published
- 1997
29. Effect of intravenously applied canrenoate on ampullar endolymphatic potential.
- Author
-
Yura K, Mori N, Nario K, and Sakai S
- Subjects
- Aldosterone physiology, Animals, Canrenoic Acid administration & dosage, Dose-Response Relationship, Drug, Electrophysiology, Guinea Pigs, Infusions, Intravenous, Mineralocorticoid Receptor Antagonists administration & dosage, Canrenoic Acid pharmacology, Endolymph drug effects, Endolymph physiology, Mineralocorticoid Receptor Antagonists pharmacology, Semicircular Canals physiology
- Abstract
The effect of canrenoate, an aldosterone antagonist, on the ampullar endolymphatic potential (AEP) was examined to assess a possible role for aldosterone in the ampulla. Intravenous administration of canrenoate increased the AEP amplitude in a dose-dependent manner, with a significant reduction of the AEP negative component induced by anoxia. Pretreatment with aldosterone attenuated the AEP change produced by canrenoate. The results suggest that aldosterone may be involved in the modulation of ampullar function.
- Published
- 1995
- Full Text
- View/download PDF
30. [Contingent negative variation elicited by electrical taste stimulation].
- Author
-
Kitaoku Y, Yamamoto T, Nario K, and Matsunaga T
- Subjects
- Acoustic Stimulation, Adult, Female, Humans, Male, Methods, Contingent Negative Variation physiology, Electric Stimulation, Taste physiology
- Abstract
Contingent negative variation (CNV) was elicited using electrical taste stimulation as the warning stimulus. Stimuli were generated for 100 msec or 500 msec using a bipolar stainless steel electrode disc with the center portion acting as the anode and the outer portion as the cathode. The imperative stimulus was a pure tone of 1 kHz at 60 dB and the interstimulus interval of paired stimuli was 2000 msec. The electrode was gently held in contact with the tongue by a specially made fixture and electrical taste stimuli were presented at 5-sec intervals. The CNV was recorded in 10 normal subjects at the Cz site of the 10-20 International System, referred to linked earlobes with a forehead ground. The results from 20 presentations were averaged. The mean threshold measured by electrogustometry employing a monopolar electrode as the anode was -4.2 dB (0 dB = 8 microA), and the mean thresholds measured with the bipolar electrode at a stimulus duration of 100 msec and 500 msec were 0 dB and -1.4 dB, respectively. As the mean threshold obtained with a duration of 500 msec was closer to the electrogustometry findings than that obtained with a duration of 100 msec, a stimulus duration of 500 msec was useful for determining the CNV threshold. The CNV could be recorded in all 10 normal subjects, and the late component was conspicuous because of recording at the Cz site. In four subjects, the P300 could be recorded after the warning stimulus at an intensity of 40 microA.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1994
- Full Text
- View/download PDF
31. [Extratympanic electrocochleography during the glycerol dehydration test in control subjects with normal hearing].
- Author
-
Kitaoku Y, Nario K, and Matsunaga T
- Subjects
- Adolescent, Adult, Female, Humans, Male, Audiometry, Evoked Response methods, Glycerol pharmacology
- Abstract
Extratympanic electrocochleography with click stimulation at 80 dBnHL was performed in 15 subjects with normal hearing (28 ears) during the glycerol dehydration test. Testing was performed before oral administration of glycerol (1.2 ml/Kg) as well as after 1, 2, and 3 hours. The mean electrocochleography response from 12 recordings was determined to obtain stable values. Although some ear action potential (AP) amplitudes increased at 1 hour after administration, the AP amplitudes gradually decreased during the test. There were significant differences between before and at 2 and 3 hours after administration. Summating potential (SP) amplitudes increased slightly, but there were no significant differences between before and each time after glycerol administration. Negative SP/AP ratios gradually increased during the test, and there were significant differences between before and each time after glycerol administration. Laterality of the glycerol-induced changes in 13 subjects having both ears tested was positive at 1 and 2 hours after glycerol administration, but the laterality had diminished by 3 hours after administration. It was thus reasonable to compare both ears at 3 hours after glycerol administration.
- Published
- 1993
- Full Text
- View/download PDF
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