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4. A decade with anomic primary progressive aphasia

Author

Ota, Shoko, primary, Kakinuma, Kazuo, additional, Narita, Wataru, additional, Nishio, Yoshiyuki, additional, Kawakami, Nobuko, additional, Tamagake, Ayane, additional, Kanno, Shigenori, additional, Matsuda, Minoru, additional, and Suzuki, Kyoko, additional

Published
2024
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8. Mirror writing and cortical hypometabolism in Parkinson’s disease

Author

Shinohara, Mayumi, primary, Yokoi, Kayoko, additional, Hirayama, Kazumi, additional, Kanno, Shigenori, additional, Hosokai, Yoshiyuki, additional, Nishio, Yoshiyuki, additional, Ishioka, Toshiyuki, additional, Otsuki, Mika, additional, Takeda, Atsushi, additional, Baba, Toru, additional, Aoki, Masashi, additional, Hasegawa, Takafumi, additional, Kikuchi, Akio, additional, Narita, Wataru, additional, Mori, Etsuro, additional, and Suzuki, Kyoko, additional

Published
2022
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16. Echolalia in patients with primary progressive aphasia

Author

Ota, Shoko, primary, Kanno, Shigenori, additional, Morita, Ayumi, additional, Narita, Wataru, additional, Kawakami, Nobuko, additional, Kakinuma, Kazuo, additional, Saito, Yumiko, additional, Kobayashi, Erena, additional, Baba, Toru, additional, Iizuka, Osamu, additional, Nishio, Yoshiyuki, additional, Matsuda, Minoru, additional, Odagiri, Hayato, additional, Endo, Keiko, additional, Takanami, Kentaro, additional, Mori, Etsuro, additional, and Suzuki, Kyoko, additional

Published
2020
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19. Echolalia in patients with primary progressive aphasia.

Author

Ota, Shoko, Kanno, Shigenori, Morita, Ayumi, Narita, Wataru, Kawakami, Nobuko, Kakinuma, Kazuo, Saito, Yumiko, Kobayashi, Erena, Baba, Toru, Iizuka, Osamu, Nishio, Yoshiyuki, Matsuda, Minoru, Odagiri, Hayato, Endo, Keiko, Takanami, Kentaro, Mori, Etsuro, and Suzuki, Kyoko

Subjects
SINGLE-photon emission computed tomography, FRONTOTEMPORAL lobar degeneration, APHASIA, CEREBRAL circulation, MOTOR cortex
Abstract

Objective: This study aimed to examine echolalia and its related symptoms and brain lesions in primary progressive aphasia (PPA). Methods: Forty‐five patients with PPA were included: 19 nonfluent/agrammatic variant PPA (nfvPPA), 5 semantic variant PPA, 7 logopenic variant PPA, and 14 unclassified PPA patients. We detected echolalia in unstructured conversations. An evaluation of language function and the presence of parkinsonism, grasp reflex, imitation behaviour, and disinhibition were assessed. We also measured regional cerebral blood flow (rCBF) using single‐photon emission computed tomography. Results: Echolalia was observed in 12 nfvPPA and 2 unclassified PPA patients. All patients showed mitigated echolalia. We compared nfvPPA patients with echolalia (echolalia group) to those without echolalia (non‐echolalia group). The median age of the echolalia group was significantly lower than that of the non‐echolalia group, and the echolalia group showed a significantly worse auditory comprehension performance than the non‐echolalia group. In contrast, the performance of repetition tasks was not different between the two groups. The prevalence of imitation behaviour in the echolalia group was significantly higher than that in the non‐echolalia group. The rCBFs in the bilateral pre‐supplementary motor area and bilateral middle cingulate cortex in the echolalia group were significantly lower than those in the non‐echolalia group. Conclusions: These findings suggest that echolalia is characteristic of nfvPPA patients with impaired comprehension. Reduced inhibition of the medial frontal cortex with release activity of the anterior perisylvian area account for the emergence of echolalia. [ABSTRACT FROM AUTHOR]

Published
2021
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28. External dose audits for high energy X-rays used in radiotherapy by ANTM

Author

Sakata, Suoh, Fukumura, Akifumi, Mizuno, Hideyuki, Yajima, Nobuhiro Takase Saki Uesaka Tetsuro Katayose Kaori, and Yamashita, Katsuhisa Narita Wataru

Abstract

In 2007, the Association for Nuclear Technology in Medicine (ANTM) set up an external audit system to check doses of high energy X-rays used in radiotherapy. The audits are based on measurements made with glass dosimeters (GD-302M, Ashahi Technoglass, Co.) that consist of fluorescent glass of rod type. In the audit, glass dosimeters are sent to institution by delivery service according to the request. After the irradiation of certain dose glass dosimeters are returned to ANTM, and the dose given to dosimeter is evaluated at ANTM Dose Calibration Center. The dose is compared with the one stated by the institution, and results of the audit are reported to the institution. Initially, audits by ANTM were limited to outputs of standard condition. However, from 2010, objects of the audit have been expanded to field and wedge conditions. By the end of 2010, 499 beams of 187 treatment machines have been audited by this system. For 320 beams of reference condition the mean and standard deviation of the ratio of doses were 1.043 and 0.0101. In 2010 (the first year of non-reference condition service), the numbers of beams checked with wedge factor and for field factor were 53 and 126, respectively., Japan-Korea Joint Meeting on Medical Physics and 11th Asia-Osecania Congress of Medical Physics

Published
2011

30. A discriminative measure for static postural control ability to prevent in-hospital falls: Reliability and validity of the Standing Test for Imbalance and Disequilibrium (SIDE)

Author

Teranishi, Toshio, primary, Kondo, Izumi, additional, Sonoda, Shigeru, additional, Kagaya, Hitoshi, additional, Wada, Yosuke, additional, Miyasaka, Hiroyuki, additional, Tanino, Genichi, additional, Narita, Wataru, additional, Sakurai, Hiroaki, additional, Okada, Makoto, additional, and Saitoh, Eiichi, additional

Published
2010
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32. Amyloid deposits and response to shunt surgery in idiopathic normal-pressure hydrocephalus.

Author

Hiraoka, Kotaro, Narita, Wataru, Kikuchi, Hirokazu, Baba, Toru, Kanno, Shigenori, Iizuka, Osamu, Tashiro, Manabu, Furumoto, Shozo, Okamura, Nobuyuki, Furukawa, Katsutoshi, Arai, Hiroyuki, Iwata, Ren, Mori, Etsuro, and Yanai, Kazuhiko

Subjects
*AMYLOID, *SURGICAL anastomosis, *HYDROCEPHALUS, *ALZHEIMER'S patients, *BIOPSY, *CEREBROSPINAL fluid, *PATIENTS
Abstract

Objectives In previous studies, patients with idiopathic normal-pressure hydrocephalus (iNPH) occasionally showed Alzheimer's pathology in frontal lobe cortical biopsy during cerebrospinal fluid shunt surgery or intracranial pressure monitoring. In clinical practice, the differential diagnosis of iNPH from Alzheimer's disease (AD) can be problematic, particularly because some iNPH cases exhibit AD comorbidity. In this study, we evaluated amyloid deposition in the brains of patients with iNPH before shunt surgery, and investigated the association between brain amyloid deposits and clinical improvement following the surgery. Materials & methods Amyloid imaging was performed in patients with iNPH or AD and also in healthy control subjects by using positron emission tomography (PET) and a radiolabeled pharmaceutical compound, 11 C-BF227. Using the cerebellar hemispheres as reference regions, the standard uptake value ratio (SUVR) of the neocortex was estimated and used as an index for amyloid deposition. In patients with iNPH, clinical symptoms were assessed before shunt surgery and 3 months after surgery. Results Five of the 10 patients with iNPH had neocortical SUVRs that were as high as those of AD subjects, whereas the SUVRs of the 5 patients were as low as those of healthy controls. A significant inverse correlation between neocortical SUVRs and cognitive improvements after shunt surgery was observed in iNPH. Conclusions The amount of amyloid deposits ranges widely in the brains of patients with iNPH and is associated with the degree of cognitive improvement after shunt surgery. [ABSTRACT FROM AUTHOR]

Published
2015
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