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This study utilizes density functional theory (DFT) with the Tran–Blaha modified Becke–Johnson (TB-mBJ) exchange potential in the WIEN2k framework to comprehensively investigate the structural, electronic, elastic, and optical properties of Rb2TlIrF6 and Rb2TlRhF6 double perovskite compounds. Structural stability assessments affirm that both materials maintain their integrity under standard conditions, demonstrating robust frameworks. The calculated elastic constants reveal mechanical stability, elasticity, and directional anisotropy, emphasizing their resilience and adaptability in varied environments. Electronic band structure calculations categorize Rb2TlIrF6 and Rb2TlRhF6 as direct bandgap semiconductors, with respective bandgaps of 2.61 eV and 1.94 eV at the L–L symmetry points, underscoring their potential in optoelectronic applications. The optical properties were analyzed through key parameters: refractive index n(ω), optical conductivity σ(ω), reflectivity R(ω), absorption coefficient α(ω), and extinction coefficient k(ω). Additionally, the real and imaginary parts of the dielectric function ∊1(ω) and ∊2(ω) were evaluated, indicating effective light interaction and absorption properties in the visible to UV range. These findings suggest that Rb2TlIrF6 and Rb2TlRhF6 exhibit advantageous optoelectronic characteristics suitable for semiconductor and next-generation electronic devices.

The zinc-based perovskites ZnLiX3 (X = Cl or F) were investigated for their structural, electronic, and optical properties using the WIEN2k package within density functional theory (DFT). Structural properties were calculated using the generalized gradient approximation (GGA), while the modified Becke-Johnson (mBJ) potential was applied for a more accurate description of the optical and electronic properties. Both compounds are confirmed to be stable, crystallizing in the cubic Pm-3 m (No. 221) space group. ZnLiCl3 has an indirect band gap of 0.30 eV between the Γ and M symmetry points, indicating semiconducting behaviour, while ZnLiF3 exhibits an indirect band gap of 5.45 eV, typical of an insulating material. The electronic states contributing to the band structure were analyzed using the total density of states (TDOS) and partial density of states (PDOS). Optical properties, evaluated in the energy range of 0–14 eV, reveal strong optical conductivity and absorption at higher energies, while both materials show transparency to lower-energy photons. These findings suggest that ZnLiCl3 and ZnLiF3 are suitable candidates for high-frequency UV optoelectronic device applications.

Abstract Recently, MAX phases have attained considerable technological interest owing to their two inherent properties metallic and ceramic properties. This study extensively examined Nb2ScAC2 MAX phases using DFT, to assess the structural, mechanical, electronic, and Thermal characteristics. Firstly, the stability of these two compounds was confirmed through the formation energy, elastic constants (Cij), and phonon band structure, which confirmed their thermodynamic, mechanical, and dynamical stability. The optimized lattice parameters of these compounds were examined and then utilized to calculate the physical properties of the Nb2ScAC2 compound. Our compounds are brittle due to their Pugh’s ratio of less than 1.75. The covalent bonding of the structure revealed by the Poisson ratio is less than 0.25 for the two compounds. The Nb2ScAC2 material is anisotropic, and Nb2ScAlC2 is harder than Nb2ScSiC2.The metallic character of the materials was affirmed by the electronic band structure analysis. Calculated thermal properties such as Debye temperature and minimum and lattice thermal conductivity reveal that both compounds have the potential to enhance their deployment in thermal barrier coating materials. On the other hand, the high melting temperatures indicate that our compounds could potentially be utilized in demanding or severe conditions. Finally, the thermodynamic characteristics, comprising the isochoric heat capacity (Cv) and Debye temperature (ϴD) were analyzed subjected to high temperatures and pressures. The optical constants such as real and imaginary parts of the dielectric function, refractive index and reflectivity, are investigated. The current study recognizes these two compounds as promising candidates for utilization in modern technologies and diverse industries.

The authors report a scheme for enhancing the photodegradation properties of TiO2 nanoparticles (TiO2 NPs) by controlling their structural phases through cations doping (cobalt and Sulfur). Cobalt-sulfur co-doped TiO2 nanoparticles were synthesized via a hydrothermal process, with sulfur content varying at levels of 0.69, 1.37, and 2.06 atomic percent (at. %), while maintaining a constant cobalt content of 0.2 at. %. Our finding shows that the methyl blue dye loaded with pure TiO2 degraded marginally in 120 min (⁓ 10.5%) while in the presence of an optimally doped sample (Co: 0.2 at. %, S 2.06 at. %), it degraded almost 93% for the same duration. The study explores the underlying physical mechanisms that contribute to the varying levels of photoactivity, and these mechanisms are found to be influenced by the valency of the doping agents. The findings of this study demonstrate that precise control over the formation of the anatase phase through doping enables the production of a remarkably efficient TiO2-based photocatalyst. Our results indicate great prospects in enhancing TiO2-based photocatalyst development chemically, a suitable approach for large-scale nanoparticle production for industrial applications.

In this research, the approach of FP-LAPW (full potential linearized augmented plane wave) is employed within WIEN2K for the investigations of structural, thermodynamic, electronic, and mechanical properties of the V2ScSnC2 and Nb2ScSnC2 MAX-phases quaternary compounds. The V2ScSnC2 and Nb2ScSnC2 compounds exist in “α” and “β” polymorph structures. The formation energies (Eform) investigated insure that the α-polymorph is more stable than the β one. As it happens, Nb2ScSnC2 is more stable than V2ScSnC2. The Nb2ScSnC2 has an enhanced mechanical property compared to the V2ScSnC2 compound. The elastic constants (ECs) of interested materials fulfill all the conditions of mechanical stability and revealed a ductile nature. The predicted Cauchy's pressure and Poisson's ratio possess positive values signifying the ionic character of the V2ScSnC2 compound. The quaternary Nb2ScSnC2 compound exists as amalgamation of covalent and ionic bonds with a predominance of the ionic bonding character. The high melting temperature and high Debye temperature of V2ScSnC2 and Nb2ScSnC2 make them suitable for use in harsh environments. Furthermore, they exhibit potential as a promising material for thermal barrier coatings (TBCs). Electronic structure analysis confirm the metallic character of the two interested compounds. At high temperatures and pressures the thermodynamic properties including the Cv (Heat capacity) and ƟD (Debye temperature) are explored. We deem that this study of quaternary MAX-phase compounds will bring new insight for the experimentalists to employ for their future applications.

Investigating novel compounds has become necessary due to the need for sophisticated materials in optoelectronic devices and spintronics. Because of their unique properties, magnesium-based spinels MgSm2X4 (X = S and Se) are very promising for these applications. We used the spin-polarized PBEsol for structural properties and the PBEsol functional for mechanical behavior, both using the WIEN2k code. Both compounds' stability in the magnetic and non-magnetic phases was validated by the Birch-Murnaghan equation of state, and their stability in the cubic phase was verified by the Born stability criterion. Their ductile character was shown by the computation of Pugh's ratio and Poisson ratio. Both MgSm2S4 and MgSm2Se4 display metallic behavior in the spin-up channel and semiconducting behavior in the spin-down channel, indicating a half-metallic nature, according to TB-mBJ potential calculations. With total magnetic moments of 20 μB, both materials showed ferromagnetic properties. Samarium ions contributed 5.27 μB for MgSm2S4 and 5.34 μB for MgSm2Se4. Furthermore, we computed optical parameters in the energy range of 0 to 15 eV, such as absorption, extinction coefficient, reflectivity, dielectric function, and refractive index. Our results demonstrate the potential of MgSm2X4 spinels for future technological developments by revealing their prospective optoelectronic and spintronic applications.

Abstract The intensified quest for efficient materials drives us to study the alkali (Na)-based niobate (NaNbO3) and tantalate (NaTaO3) perovskites while exploiting the first-principles approach based on density functional theory, coded within WIEN2K. While using the Birch Murnaghan fit, we find these materials to be stable structurally. Similarly, the ab-initio molecular dynamics simulations (AIMD) at room temperature reveals that the compounds exhibit no structural distortion and are stable at room temperature. By using the recommended modified Becke–Johnson potential, we determine the electronic characteristics of the present materials providing insight into their nature: they are revealed to be indirect semiconductors with the calculated bandgaps of 2.5 and 3.8 eV for NaNbO3 and NaTaO3, respectively. We also determine the total and partial density of states for both materials and the results obtained for the bandgap energies of these materials are consistent with those determined by the band structure. We find that both compounds exhibit transparency to the striking photon at low energy and demonstrate absorption and optical conduction in the UV region. The elastic study shows that these compounds are mechanically stable, whereas NaNbO3 exhibits stronger ability to withstand compressive as well as shear stresses and resists change in shape while NaTaO3 demonstrates weaker ability to resist change in volume. We also find that none of the compound is perfectly isotropic and NaNbO3 and NaTaO3 are ductile and brittle in nature, respectively. By studying the optical properties of these materials, we infer that they are promising candidates for applications in optoelectronic devices. We believe that this report will invoke the experimental studies for further investigation.

In this study, the investigations of structural, electronic, optical, and magnetic properties of a scintillating double perovskite halide (Cs2LiCeCl6) by using the full-potential linearized augmented plane wave (FP-LAPW) method in the framework of density functional theory (DFT) is reported. The optimized lattice constant (a0) is fully consistent with the experimental results, and the ground state optimized energy confirms the cubic (Fm 3¯ m space group) stability of the compound. The electronic band structures and densities of states are analyzed within approximations of PBE-GGA and TB-mBJ to have precise and accurate results. In the spin-up channel the metallic behavior of the compound is confirmed, while in the spin-down channel there is a band gap of 3.83 eV with an indirect nature from Γ-X, so clarifying its behavior towards semiconductors and thus overall making the compound to be half-metallic, and hence, it is clear that the material exhibit spin polarization. The ferromagnetic behavior is verified by the asymmetric density of states in both spin channels and the optimized energy volume curve in spin-polarized calculations. The optical parameters are computed and it is found that the compound Cs2LiCeCl6 possesses high optical conductivity, absorption coefficient and compared in both approximations and analyzed in the energy range of (0–20) eV and hence predict the applications of this material in high-frequency ultraviolet devices and also for particle detection.

Herein the first-principle modeling within the DFT framework is used to investigate the structural, optoelectronic, elastic, and thermoelectric properties of BaMF3 (M = Ag and Cu) ternary halide Perovskites compounds. The computed tolerance factors for BaAgF3 and BaCuF3 are 0.919 and 0.991 respectively, indicating that the cubic crystal phase of these selected compounds is thermodynamically and mechanically stable. It is found that both the compounds are structurally stable according to the Birch-Murnaghan fit curve for optimization. The IRelast package is used for investigating the elastic properties of both cubic compounds and the findings show that these compounds are mechanically stable, scratch-resistant, ductile, anisotropic, and resistant to plastic deformation. The Trans-Blaha modified Becke-Johnson (TB-mBJ) approximation is employed to determine electronic properties with accuracy and precision. The electronic-band structure analysis depicts a narrow band gap semiconductor nature of BaAgF3 and BaCuF3 compounds which displays indirect band gaps of 0.2 eV for BaAgF3 and 0.3 eV for BaCuF3 at the high symmetrical points from (Γ–M). Furthermore, the computations of total densities of states (TDOS) and partial densities of states (PDOS) are carried out to determine how different states contribute to the various band structures. The optical characteristics of BaAgF3 and BaCuF3 are comprehensively examined in 0–40 eV energy ranges. The selected materials possess high optical conduction and absorption coefficients at the high level of photon energies and show transparency at low incident photon energy ranges. The investigations of optical properties led us to the conclusion that BaAgF3 and BaCuF3 are suitable to use in high-frequency UV devices. The thermoelectric properties show that both materials hold high-power factors, electrical conductivity, and figures of merit (ZT), indicating that they are good thermoelectric materials. This is the first theoretical computational systematic analysis of structural, optoelectronic, elastic, and thermoelectric properties of BaMF3 (M = Ag and Cu) that will be experimentally validated to our knowledge.

This work explains the first-principle computational inquiry of physical features of BWF3 (W = S and Si) halide-Perovskites compounds. With the aid of the WIEN2K code, our recent computation solely relies on Density Functional Theory (DFT). Using the equation of states made by Birch Murnaghan for optimization. The elastic factors are figure out and used to compute elastic characteristics, we found that both composites are structurally as well elastically stable. These substances exhibit strong resistance to plastic strain and are show ductility, scratch-resistant and anisotropic. BSF3 and BSiF3 are both metal-like substances, according to calculations made using the Tb-mBJ) potential approach. Density of states calculations are recycled to conclude how different energy states are involved in band structures. These compounds' band gap energies make it simple to study various optical characteristics. These chemicals exhibit strong absorption at high energy ranges. The compound BSF3 is transparent to incoming photons at low energies, while the complex BSiF3 is opaque. We have come to the conclusion that the compounds BSF3 and BSiF3 can be employed for high-frequency UV device applications as a result of our study into their optical properties. For the first time, our computational effort is calculated to investigate these substances that have not yet been experimentally proven to our satisfaction.

Al-based fluoroperovskites compounds AlMF3 (M = Cu, Mn) are researched computationally, and their various aspects are examined using TB-MBJ potential approximations for energy generation. This is due to their increasing power conversion efficiency, which has drawn a lot of attention. These compounds are cubic and stable in terms of structure, according to the Birch Murnaghan curve and tolerance factor. Computed are the optimised lattice parameters and the optimal volume Vo of the compounds matching the ideal energies. These compounds are mechanically stable, anisotropic, and ductile, according to the IRelast algorithm's predictions of elastic properties. At (X-M) symmetry points, AlCuF3 and AlMnF3 have a small indirect band gap, with band gaps of −0.54 eV for AlCuF3 and 0.45 eV for AlMnF3, respectively. The AlCuF3 compounds' narrow indirect band gap reveals their metallic character. AlMnF3, however, is a semiconductor. The offering of various elemental states to the conduction and valence bands is calculated using the partial and total density of states (TDOS & PDOS). These compounds exhibit low refractive index, high absorption coefficient, and conductivity at high energy ranges, according to an analysis of their optical properties. These compounds have applications in conducting industries because of the indirect band gap. Here, we used these compounds for the first time and used a computational method to study them, which provides a comprehensive perspective of all the various features.

The Impact of Co and Gd on the structural, magnetic and dielectric properties of ZnO nanotubes synthesized by co-precipitation is reported. The results demonstrate that incorporating Co and Gd into ZnO diminished crystallinity while retaining the optimum orientation. The outcomes of transmission electron microscopy and scanning electron microscopy examined that the Co and Gd dopants had no effect on the morphology of the produced nanotubes. It was also discovered that as the frequency and concentration of Gd co-dopant decreased, the dielectric constant and loss values increased. When doping was present, the dielectric constant and ac electrical conductivity response was found to be inversely related. Ultimately, at 300K, Co and Gd co-doped ZnO nanotubes exhibited ferromagnetic properties. When Gd doping was increased to 3%, the ferromagnetic response increased. Since then, increasing the Gd co-doping, the ferromagnetic response decreased. For the same sample (Zn0.96−xCo0.04Gd0.03O nanotubes), the electrical conductivity exhibited also superior to pure and low Gd doped ZnO. Its high ferromagnetism is usually caused by magnetic impurities replaced on the ZnO side. Therefore, considering the behaviour of these nanotubes, it can be sued spin-based electronics.

This research is being conducted to learn more about various compounds and their potential uses in various fields such as renewable energy, electrical conductivity, the study of optoelectronic properties, the use of light-absorbing materials in photovoltaic device thin-film LEDs, and field effect transistors (FETs). AgZF3 (Z = Sb, Bi) compounds, which are simple, cubic, ternary fluoro-perovskites, are studied using the FP-LAPW and low orbital algorithm, both of which are based on DFT. Structure, elasticity and electrical and optical properties are only some of the many features that can be predicted. The TB-mBJ method is used to analyze several property types. An important finding of this study is an increase in the bulk modulus value after switching Sb to Bi as the metallic cation designated as “Z” demonstrates the stiffness characteristic of a material. The anisotropy and mechanical balance of the underexplored compounds are also revealed. Our compounds are ductile, as evidenced by the calculated Poisson ratio, Cauchy pressure, and Pugh ratio values. Both compounds exhibit indirect band gaps (X-M), with the lowest points of the conduction bands located at the evenness point X and the highest points of the valence bands located at the symmetry point M. The principal peaks in the optical spectrum can be understood in light of the observed electronic structure.

This work describes an ab initio principle computational examination of the optical, structural, elastic, electronic and mechanical characteristics of aluminum-based compounds AlRF3 (R = N, P) halide-perovskites. For optimization purposes, we used the Birch–Murnaghan equation of state and discovered that the compounds AlNF3 and AlPF3 are both structurally stable. The IRelast software was used to compute elastic constants (ECs) of the elastic properties. The aforementioned compounds are stable mechanically. They exhibit strong resistance to plastic strain, possess ductile nature and anisotropic behavior and are scratch-resistant. The modified Becke–Johnson (Tb-mBJ) approximation was adopted to compute various physical properties, revealing that AlNF3 and AlPF3 are both metals in nature. From the density of states, the support of various electronic states in the band structures are explained. Other various optical characteristics have been calculated from the investigations of the band gap energy of the aforementioned compounds. These compounds absorb a significant amount of energy at high levels. At low energy levels, the compound AlNF3 is transparent to incoming photons, whereas the compound AlPF3 is somewhat opaque. The examination of the visual details led us to the deduction that the compounds AlNF3 and AlPF3 may be used in making ultraviolet devices based on high frequency. This computational effort is being made for the first time in order to investigate the aforementioned properties of these chemicals, which have yet to be confirmed experimentally.

Aims: To identify the changes in cardiovascular disease presentation, emergency room triage and inpatient diagnostic and therapeutic pathways. Methods: We conducted a retrospective cohort study at the Aga Khan University Hospital, Karachi. We collected data for patients presenting to the emergency department with cardiovascular symptoms between March–July 2019 (pre-COVID period) and March–July 2020 (COVID period). The comparison was made to quantify the differences in demographics, clinical characteristics, admission, diagnostic and therapeutic procedures, and in-hospital mortality between the two periods. Results: Of 2976 patients presenting with cardiac complaints to the emergency department (ED), 2041(69%) patients presented during the pre-COVID period, and 935 (31%) patients presented during the COVID period. There was significant reduction in acute coronary syndrome (ACS) (8% [95% CI 4–11], p < 0.001) and heart failure (↓6% [95% CI 3–8], p < 0.001). A striking surge was noted in Type II Myocardial injury (↑18% [95% CI 20–15], p < 0.001) during the pandemic. There was reduction in cardiovascular admissions (coronary care unit p < 0.01, coronary step-down unit p = 0.03), cardiovascular imaging (p < 0.001), and procedures (percutaneous coronary intervention p = 0.04 and coronary angiography p = 0.02). No significant difference was noted in mortality (4.7% vs. 3.7%). The percentage of patients presenting from rural areas declined significantly during the COVID period (18% vs. 14%, p = 0.01). In the subgroup analysis of sex, we noticed a falling trend of intervention performed in females during the COVID period (8.2% male vs. 3.3 % female). Conclusions: This study shows a significant decline in patients presenting with Type I myocardial infarction (MI) and a decrease in cardiovascular imaging and procedures during the COVID period. There was a significant increase noted in Type II MI.

Prediction of new materials is crucial for the advancement of technology. Here, in this research work, the first-principle computation has been conducted utilizing the WIEN2K package to probe the structural, electronic, mechanical, and optical properties of barium-based chloroperovskites BaMCl3 (M = Ag, Cu) compounds. The optimized lattice constants are calculated for both compounds which are 9.90 Bohr for BaAgCl3 and 9.38 Bohr for BaCuCl3. To obtain better and more precise results for the electronic band’s structure, TDOS and PDOS (total and partial density of states), and the TB-mBJ potential approximation are employed. The indirect band gap (R–Γ) is found for both compounds having values of 1.173 eV and 2.30 eV for BaCuCl3 and BaAgCl3, respectively, which depicts its semiconducting nature. The calculation of elastic properties is conducted with IRelast code. The Cauchy pressure, Bulk modulus, Young’s modulus, Shear modulus, anisotropic ratio, Kleinman parameters, and Poisson’s ratio are calculated from the obtained elastic constants. The computation of elastic parameters indicates that the interested chloroperovskites are anisotropic, mechanically stable, hard to scratch, and ductile. From 0 eV to 40 eV incident photon energy ranges, the various optical parameter such as refractive index, absorption coefficient, dielectric function, reflectivity, extinction coefficient, and optical conductivity are analyzed. These compounds absorb maximum light within 5 to 25 eV incident photon energy. Hence, these materials are good light absorbers, therefore, they can be used in optoelectronic devices for high-frequency applications.

Chloro-perovskites having attractive properties, especially lead-containing chloro-perovskites, have potential application in the electrical and electronic industry. However, the toxic nature of lead puts a constraint on its practical applications. In the present study, lead is replaced by Rh and Be in Cs-based chloro-perovskites. The mechanical, optical, electronic, structural, and magnetic properties of the compounds CsRhCl3 and CsBeCl3 are studied by using the full-potential linearized augmented plane wave method. The band structure study indicates that CsRhCl3 is half-metallic while CsBeCl3 has a semiconducting nature with an indirect bandgap of 2.27 eV. The elastic constant calculated through the IRelast package verified the ionic nature and highly anisotropic and ductile behavior of both compounds. The determined magnetic moment values show the paramagnetic nature of both materials. The investigated optical properties clarify the transmitting nature in the energy range of 0–14.5 eV and the reflecting nature in the range of 14.5–25.5 eV. The compounds are optical conductors in the ultraviolet region.

This paper explains our first-principle computational investigation regarding the structural, optical, elastic, and electrical characteristics of gallium-based GaMF3 (M = Be and Ge) perovskite-type (halide-perovskite) compounds. Our current computation is based on density functional theory (DFT) and is achieved with the help of the WIEN2k code. We used the Birch–Murnaghan equation for optimization; in both compounds, we found that both GaBeF3 and GaGeF3 compounds are structurally stable. For the computation of elastic characteristics, the IRelast package for calculating elastic constants (ECs) is utilized. These compounds are mechanically ductile, scratch-resistant, anisotropic, and mechanically stable, showing huge opposition to plastic strain. The modified Becke–Johnson (TB-mBJ) potential approximation method is used to calculate different physical characteristics and shows that GaGeF3 behaves as a metal, whereas the GaBeF3 compound is insulating in nature. The involvement of various electronic states in band structures is calculated using the theory of the density of states. The different optical properties of these compounds can be studied easily using their band gap energy. At high energy ranges, these substances demonstrate strong absorption. At low energies, the GaGeF3 compound is transparent, while the GaBeF3 compound is opaque to incoming photons. Investigation of the optical characteristics has led us to the conclusion that both GaGeF3 and GaBeF3 compounds can be used for high-frequency ultraviolet device applications. This computational work is considered to be the first time that we can study these compounds, which to our knowledge have not previously been experimentally validated.

Tin-based nanocomposite materials embedded in carbon frameworks can be used as effective negative electrode materials for lithium-ion batteries (LIBs), owing to their high theoretical capacities with stable cycle performance. In this work, a low-cost and productive facile hydrothermal method was employed for the preparation of a Sn/C nanocomposite, in which Sn particles (sized in nanometers) were uniformly dispersed in the conductive carbon matrix. The as-prepared Sn/C nanocomposite displayed a considerable reversible capacity of 877 mAhg−1 at 0.1 Ag−1 with a high first cycle charge/discharge coulombic efficiency of about 77%, and showed 668 mAh/g even at a relatively high current density of 0.5 Ag−1 after 100 cycles. Furthermore, excellent rate capability performance was achieved for 806, 697, 630, 516, and 354 mAhg−1 at current densities 0.1, 0.25, 0.5, 0.75, and 1 Ag−1, respectively. This outstanding and significantly improved electrochemical performance is attributed to the good distribution of Sn nanoparticles in the carbon framework, which helped to produce Sn/C nanocomposite next-generation negative electrodes for lithium-ion storage.

This theoretical study is performed to investigate structural, elastic, and electronic properties as well as optical response to incident photons of thallium based chloroperovskite TlXCl3 (X = Ca and Cd) compounds. Both compounds have a stable crystal structure with optimized lattice constants ranging from 5.40 Å to 5.26 Å. The elastic parameters such as elastic constants, bulk modulus, anisotropy factor, Poisson’s ratio, and Pugh’s ratio are evaluated. Poisson’s ratio describes the ductile nature of these materials. The band structure and elemental contribution to different states for all the compounds are analyzed. Materials have a wide bandgap with indirect band nature. Optical parameters such as dielectric function, refractive index, extinction coefficient, reflectivity, absorption coefficient, and optical conductivity are studied in the energy range of 0 eV–30 eV. The comparative results suggest that thallium based compounds are important to be used as scintillating materials and stimulate further experimental investigations of such compounds.

BACKGROUND:We developed and tested the effectiveness of a tailored health information technology driven intervention: "Talking Prescriptions" (Talking Rx) to improve medication adherence in a resource challenged environment. METHODS:We conducted a parallel, randomized, controlled, assessor-blinded trial at the Aga Khan University (AKU), Karachi, Pakistan. Adults with diagnosis of cerebrovascular accident (CVA) or coronary artery disease (CAD) diagnosed least one month before enrollment, on anti-platelets and statins, with access to a mobile phone were enrolled. The intervention group received a) Daily Interactive Voice Response (IVR) call services regarding specific statin and antiplatelet b) Daily tailored medication reminders for statin and antiplatelet and c) Weekly lifestyle modification messages for a period of 3 months. We assessed Medication adherence to statin and antiplatelets by a validated version of the 8-item Morisky Medication Adherence scale 8 (MMAS-8) at 3 months by a blinded assessment officer. Analysis was conducted by intention-to-treat principle (ITT). RESULTS:Between April 2015 and December 2015, 197 participants (99 in intervention and 98 in the usual care group) enrolled in the Talking Rx Study. The dropout rate was 9.6%. Baseline group characteristics were similar. At baseline, the mean MMAS-8 was 6.68 (SD = 1.28) in the intervention group and 6.77 (SD = 1.36) in usual care group. At end of follow-up, the mean MMAS-8 increased to 7.41(0.78) in the intervention group compared with 7.38 (0.99) in usual care group with mean difference of 0.03 (S.D 0.13) (95% C.I [-0.23, 0.29]), which was not statistically significant. (P-Value = 0.40) CVA patients showed a relatively greater magnitude of adherence via the MMAS-8 at the end of follow up where the mean MMAS-8 increased to 7.29 (S.D 0.82) in the intervention group as compared to 7.07(S.D 1.24) in usual care group with mean difference of 0.22 (SD = 0.22) 95% C.I (-0.20, 0.65) with (P-value = 0.15). Around 84% of those on intervention arm used the service, calling at least 3 times and listening to their prescriptions for an average of 8 minutes. No user was excluded due to technologic reasons. CONCLUSION:The use of a phone based medication adherence program was feasible in LMIC settings with high volume clinics and low patient literacy. In this early study, with limited follow up, the program did not achieve any statistically significant differences in adherence behavior as self-reported by the MMAS-8 Scale. TRIAL REGISTRATION:Clinical Trials.gov NCT02354040.