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3. Are Bacteria Infectious Pathogens in Hidradenitis Suppurativa? Debate at the Symposium for Hidradenitis Suppurativa Advances Meeting, November 2017

Author

Naik, Haley B, Nassif, Aude, Ramesh, Mayur S, Schultz, Gregory, Piguet, Vincent, Alavi, Afsaneh, and Lowes, Michelle A

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Infectious Diseases, 2.1 Biological and endogenous factors, Aetiology, Infection, Good Health and Well Being, Bacteria, Congresses as Topic, Hidradenitis Suppurativa, Humans, Microbiota, Retrospective Studies, Oncology and Carcinogenesis, Dermatology & Venereal Diseases, Clinical sciences
Abstract

In November 2017, a formal debate on the role of bacteria in the pathogenesis of hidradenitis suppurativa (HS) was held at the 2nd Symposium on Hidradenitis Suppurativa Advances (SHSA) in Detroit, Michigan. In this report, we present both sides of the argument as debated at the SHSA meeting and then discuss the potential role of bacteria as classic infectious pathogens versus an alternative pathogenic role as activators of dysregulated commensal bacterial-host interactions. Although there was consensus that bacteria play a role in pathogenesis and thus are pathogenic, there was a compelling discussion about whether bacteria in HS incite an infectious disease as we classically understand it or whether bacteria might play a different role in HS pathogenesis.

Published
2019

4. Proceeding report of the Second Symposium on Hidradenitis Suppurativa Advances (SHSA) 2017

Author

Shavit, Eran, Alavi, Afsaneh, Bechara, Falk G, Bennett, Richard G, Bourcier, Marc, Cibotti, Ricardo, Daveluy, Steven, Frew, John W, Garg, Amit, Hamzavi, Iltefat, Hoffman, Lauren K, Hsaio, Jenny, Kirby, Joslyn Sciacca, Lev‐Tov, Hadar, Martinez, Erin, Micheletti, Robert, Naik, Haley B, Nassif, Aude, Nicholson, Cynthia, Parks‐Miller, Angie, Patel, Zarine, Piguet, Vincent, Ramesh, Mayur, Resnik, Barry, Sayed, Christopher, Schultz, Gregory, Siddiqui, Aamir, Tan, Jerry, Wortsman, Ximena, and Lowes, Michelle A

Subjects
Anti-Infective Agents, Anti-Inflammatory Agents, Biomedical Research, Comorbidity, Dermatologic Surgical Procedures, Hidradenitis Suppurativa, Humans, Incidence, Quality of Life, Tumor Necrosis Factor-alpha, Ultrasonography, hidradenitis suppurativa, symposium, Clinical Sciences, Dermatology & Venereal Diseases
Abstract

The 2nd Annual Symposium on Hidradenitis Suppurativa Advances (SHSA) took place on 03-05 November 2017 in Detroit, Michigan, USA. This symposium was a joint meeting of the Hidradenitis Suppurativa Foundation (HSF Inc.) founded in the USA, and the Canadian Hidradenitis Suppurativa Foundation (CHSF). This was the second annual meeting of the SHSA with experts from different disciplines arriving from North America, Europe and Australia, in a joint aim to discuss most recent innovations, practical challenges and potential solutions to issues related in the management and care of Hidradenitis Suppurativa patients. The last session involved clinicians, patients and their families in an effort to educate them more about the disease.

Published
2019

6. Contributors

Author

Alavi, Afsaneh, primary, Aleshin, Maria, additional, Bechara, Falk G., additional, Bennett, Richard G., additional, Birnbaum, Ron, additional, Brownstone, Nicholas, additional, Buechler, Connor R., additional, Shree' Byrd, Angel, additional, Charrow, Alexandra P., additional, Cole, Emily F., additional, Collier, Erin K., additional, Daveluy, Steven D., additional, Fernandez, Jennifer M., additional, Frew, John W., additional, Garg, Amit, additional, George, Ralph, additional, Goldberg, Stephanie R., additional, Goldfarb, Noah, additional, Guilbault, Sandra, additional, Hamzavi, Iltefat H., additional, Hazen, Paul G., additional, Henderson, Marsha, additional, Hendricks, Aleksi J., additional, Hsiao, Jennifer L., additional, Jaleel, Tarannum, additional, Johnson, Lydia J., additional, Join-Lambert, Olivier, additional, Kerns, Michelle L., additional, Kimball, Alexa B., additional, Kirby, Joslyn S., additional, Kohli, Indermeet, additional, Lenczowski, Joi, additional, Lev-Tov, Hadar, additional, Liao, Wilson, additional, Lowes, Michelle A., additional, Lyons, Alexis B., additional, Malviya, Neeta, additional, Micheletti, Robert G., additional, Morss-Walton, Peyton C., additional, Myers, Bridget, additional, Naik, Haley B., additional, Narla, Shanthi, additional, Nassif, Aude, additional, Nguyen, Tien Viet, additional, Nikolakis, Georgios, additional, O'Brien, Elizabeth, additional, Orenstein, Lauren A.V., additional, Parks-Miller, Angie, additional, Patel, Zarine S., additional, Porter, Martina L., additional, Price, Kyla N., additional, Ramesh, Mayur, additional, Resnik, Barry I., additional, Santillan, Monica Rosales, additional, Sachdeva, Muskaan, additional, Sanchez, Daniela P., additional, Savage, Kevin T., additional, Sayed, Chris, additional, Shah, Monica, additional, Shaver, Rob Leland, additional, Shi, Vivian Y., additional, Smogorzewski, Jan M., additional, Succaria, Farah, additional, Svoboda, Ryan M., additional, Thompson, Alyssa M., additional, Vaiopoulos, Aristeidis G., additional, Veerabagu, Surya A., additional, Walsh, Joseph R., additional, Weigelt, Maximillian A., additional, Wortsman, Ximena, additional, and Zouboulis, Christos C., additional

Published
2022
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8. Evaluating patients' unmet needs in hidradenitis suppurativa: Results from the Global Survey Of Impact and Healthcare Needs (VOICE) Project

Author

Garg, Amit, Neuren, Erica, Cha, Denny, Kirby, Joslyn S., Ingram, John R., Jemec, Gregor B.E., Esmann, Solveig, Thorlacius, Linnea, Villumsen, Bente, Marmol, Véronique del, Nassif, Aude, Delage, Maia, Tzellos, Thrasyvoulos, Moseng, Dagfinn, Grimstad, Øystein, Naik, Haley, Micheletti, Robert, Guilbault, Sandra, Miller, Angie Parks, Hamzavi, Iltefat, van der Zee, Hessel, Prens, Errol, Kappe, Naomi, Ardon, Christine, Kirby, Brian, Hughes, Rosalind, Zouboulis, Christos C., Nikolakis, Georgios, Bechara, Falk G., Matusiak, Lukasz, Szepietowski, Jacek, Glowaczewska, Amelia, Smith, Saxon D., Goldfarb, Noah, Daveluy, Steven, Avgoustou, Christina, Giamarellos-Bourboulis, Evangelos, Cohen, Steven, Soliman, Yssra, Brant, Elena Gonzalez, Akilov, Oleg, Sayed, Christopher, Tan, Jerry, Alavi, Afsaneh, Lowes, Michelle A., Pascual, José Carlos, Riad, Hassan, Fisher, Shani, Cohen, Arnon, Paek, So Yeon, Resnik, Barry, Ju, Qiang, Wang, Lanqi, and Strunk, Andrew

Published
2020
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9. Clinical characteristics of pediatric hidradenitis suppurativa: a cross-sectional multicenter study of 140 patients

Author

Riis, Peter Theut, Saunte, Ditte Marie, Sigsgaard, Viktoria, Villani, Axel Patrice, Guillem, Philippe, Pascual, José C., Kappe, Naomi N., Vanlaerhoven, Annika M. J. D., van der Zee, Hessel H., Prens, Errol P., El-Domyati, Moetaz, Abdel-Wahab, Hossam, Moftah, Nayera, Abdelghani, Rania, Agut-Busquet, Eugenia, Romaní, Jorge, Hlela, Carol, van den Worm, Lerinza, Bettoli, Vincenzo, Calamo, Giada, Gürer, Mehmet Ali, Beksaç, Burcu, Matusiak, Lukasz, Glowaczewska, Amelia, Szepietowski, Jacek C., Emtestam, Lennart, Lapins, Jan, Kottb, Hassan Riad, Fatani, Mohammad, Weibel, Lisa, Theiler, Martin, Delage-Toriel, Maïa, Lam, Thi Thanh Hong, Nassif, Aude, Becherel, Pierre-Andre, Dolenc-Voljc, Mateja, Doss, Nejib, Bouazzi, Dorra, Benhadou, Farida, del Marmol, Veronique, and Jemec, Gregor B. E.

Published
2020
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14. Hidradenitis suppurativa (HS): An unrecognized paradoxical effect of biologic agents (BA) used in chronic inflammatory diseases

Author

Faivre, Coline, Villani, Axel Patrice, Aubin, François, Lipsker, Dan, Bottaro, Martine, Cohen, Jean-David, Durupt, François, Jeudy, Géraldine, Sbidian, Emilie, Toussirot, Eric, Badot, Valérie, Barbarot, Sébastien, Debarbieux, Sébastien, Delaporte, Emmanuel, Goegebeur, Guetty, Morel, Jacques, Nassif, Aude, Duru, Gérard, and Jullien, Denis

Published
2016
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15. Isotretinoin‐associated acne fulminans: A multicentre, retrospective study of the European Academy of Dermatology and Venereology Task Force on Acne, Rosacea and Hidradenitis Suppurativa.

Author

Dessinioti, Clio, Dréno, Brigitte, Bettoli, Vincenzo, Vural, Secil, Brzezinski, Piotr, Nassif, Aude, Svensson, Åke, and Zouboulis, Christos C.

Subjects
HIDRADENITIS suppurativa, TASK forces, ORAL drug administration, ROSACEA, ACNE, JOINT pain
Abstract

Background: Acne fulminans (AF) is a rare severe acne entity. Although occasionally reported, it is unclear whether AF development is associated with oral isotretinoin treatment. Objectives: To investigate the occurrence of isotretinoin‐associated AF, clinical characteristics and prognosis at follow‐up. Methods: An international, multicentre, retrospective study was performed in eight hospitals following the call of the EADV Task Force on Acne, Rosacea and Hidradenitis Suppurativa (ARHS). Characteristics of patients treated with isotretinoin before the development of AF (isotretinoin‐associated acne fulminans, IAF) were compared with non‐IAF (NAF). Results: Forty‐nine patients diagnosed with AF from 2008 to 2022 were included (mean age 16.4 years, SD 2.9, 77.6% male). Αrthralgias/arthritis occurred in 11 patients (22.9%). AF occurred without any previous acne treatment in 26.5% of the patients. Overall, 28 patients (57.1%) developed AF after oral isotretinoin intake (IAF group), while the remaining 21 patients (42.9%) developed AF without previous oral isotretinoin administration (NAF group). IAF occurred after a median duration of isotretinoin treatment of 45 days (IQR: 30, 90). Patients with IAF were more frequently male compared to patients with NAF (89.3% vs. 61.9%, respectively, p = 0.023). There were no differences in patients with IAF versus NAF in patient age, the duration of pre‐existing acne, a family history of AF, the distribution of AF lesions or the presence of systemic symptoms or arthralgias. Regarding the management of AF, patients with IAF were treated more frequently with prednisolone (96.2%) compared to those with NAF (70%; p = 0.033) and less frequently with isotretinoin (32.1%) compared to NAF (85.7%; p < 0.001). At a median follow‐up of 2.2 years, 76.4% of patients were free of AF and scarring was present in all patients. Conclusions: No specific clinical or demographic characteristics of IAF compared with NAF could be detected, a fact that does not support IAF as a district clinical entity. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Factors associated with disease-specific life impact in patients with hidradenitis suppurativa: results from the Global VOICE project

Author

Garg, Amit, primary, Rawal, Sahil, additional, Akilov, Oleg, additional, Alavi, Afsaneh, additional, Ardon, Christine, additional, Bechara, Falk G, additional, Cohen, Arnon D, additional, Cohen, Steven R, additional, Daveluy, Steven, additional, del Marmol, Véronique, additional, Delage, Maïa, additional, Esmann, Solveig, additional, Fisher, Shani, additional, Giamarellos-Bourboulis, Evangelos J, additional, Glowaczewska, Amelia, additional, Goldfarb, Noah, additional, Gonzalez Brant, Elena, additional, Grimstad, Øystein, additional, Guilbault, Sandra, additional, Hamzavi, Iltefat, additional, Hughes, Rosalind, additional, Ingram, John R, additional, Jemec, Gregor B E, additional, Ju, Qiang, additional, Kappe, Naomi, additional, Kirby, Brian, additional, Kirby, Joslyn S, additional, Lowes, Michelle A, additional, Matusiak, Lukasz, additional, Micha, Stella, additional, Micheletti, Robert G, additional, Miller, Angela P, additional, Moseng, Dagfinn, additional, Naik, Haley B, additional, Nassif, Aude, additional, Nikolakis, Georgios, additional, Paek, So Yeon, additional, Pascual, Jose Carlos, additional, Prens, Errol, additional, Resnik, Barry, additional, Riad, Hassan, additional, Sayed, Christopher, additional, Smith, Saxon D, additional, Soliman, Yssra, additional, Szepietowski, Jacek C, additional, Tan, Jerry, additional, Thorlacius, Linnea, additional, Tzellos, Thrasyvoulos, additional, van der Zee, Hessel H, additional, Villumsen, Bente, additional, Wang, Lanqi, additional, Zouboulis, Christos C, additional, and Strunk, Andrew, additional

Published
2023
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19. Factors associated with treatment satisfaction in patients with hidradenitis suppurativa: results from the Global VOICE project

Author

Midgette, Bria, primary, Strunk, Andrew, additional, Akilov, Oleg, additional, Alavi, Afsaneh, additional, Ardon, Christine, additional, Bechara, Falk G., additional, Cohen, Arnon D., additional, Cohen, Steven, additional, Daveluy, Steven, additional, del Marmol, Véronique, additional, Delage, Maïa, additional, Esmann, Solveig, additional, Fisher, Shani, additional, Giamarellos-Bourboulis, Evangelos J., additional, Glowaczewska, Amelia, additional, Goldfarb, Noah, additional, Brant, Elena Gonzalez, additional, Grimstad, Øystein, additional, Guilbault, Sandra, additional, Hamzavi, Iltefat, additional, Hughes, Rosalind, additional, Ingram, John R., additional, Jemec, Gregor B.E., additional, Ju, Qiang, additional, Kappe, Naomi, additional, Kirby, Brian, additional, Kirby, Joslyn S., additional, Lowes, Michelle A., additional, Matusiak, Lukasz, additional, Micha, Stella, additional, Micheletti, Robert, additional, Miller, Angela P., additional, Moseng, Dagfinn, additional, Naik, Haley, additional, Nassif, Aude, additional, Nikolakis, Georgios, additional, Paek, So Yeon, additional, Pascual, Jose Carlos, additional, Prens, Errol, additional, Resnik, Barry, additional, Riad, Hassan, additional, Sayed, Christopher, additional, Smith, Saxon D., additional, Soliman, Yssra, additional, Szepietowski, Jacek C., additional, Tan, Jerry, additional, Thorlacius, Linnea, additional, Tzellos, Thrasyvoulos, additional, van der Zee, Hessel H., additional, Villumsen, Bente, additional, Wang, Lanqi, additional, Zouboulis, Christos, additional, and Garg, Amit, additional

Published
2022
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21. Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin

Author

Spaan, András N., primary, Neehus, Anna-Lena, additional, Laplantine, Emmanuel, additional, Staels, Frederik, additional, Ogishi, Masato, additional, Seeleuthner, Yoann, additional, Rapaport, Franck, additional, Lacey, Keenan A., additional, Van Nieuwenhove, Erika, additional, Chrabieh, Maya, additional, Hum, David, additional, Migaud, Mélanie, additional, Izmiryan, Araksya, additional, Lorenzo, Lazaro, additional, Kochetkov, Tatiana, additional, Heesterbeek, Dani A. C., additional, Bardoel, Bart W., additional, DuMont, Ashley L., additional, Dobbs, Kerry, additional, Chardonnet, Solenne, additional, Heissel, Søren, additional, Baslan, Timour, additional, Zhang, Peng, additional, Yang, Rui, additional, Bogunovic, Dusan, additional, Wunderink, Herman F., additional, Haas, Pieter-Jan A., additional, Molina, Henrik, additional, Van Buggenhout, Griet, additional, Lyonnet, Stanislas, additional, Notarangelo, Luigi D., additional, Seppänen, Mikko R. J., additional, Weil, Robert, additional, Seminario, Gisela, additional, Gomez-Tello, Héctor, additional, Wouters, Carine, additional, Mesdaghi, Mehrnaz, additional, Shahrooei, Mohammad, additional, Bossuyt, Xavier, additional, Sag, Erdal, additional, Topaloglu, Rezan, additional, Ozen, Seza, additional, Leavis, Helen L., additional, van Eijk, Maarten M. J., additional, Bezrodnik, Liliana, additional, Blancas Galicia, Lizbeth, additional, Hovnanian, Alain, additional, Nassif, Aude, additional, Bader-Meunier, Brigitte, additional, Neven, Bénédicte, additional, Meyts, Isabelle, additional, Schrijvers, Rik, additional, Puel, Anne, additional, Bustamante, Jacinta, additional, Aksentijevich, Ivona, additional, Kastner, Daniel L., additional, Torres, Victor J., additional, Humblet-Baron, Stéphanie, additional, Liston, Adrian, additional, Abel, Laurent, additional, Boisson, Bertrand, additional, and Casanova, Jean-Laurent, additional

Published
2022
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23. Factors associated with treatment satisfaction in patients with hidradenitis suppurativa:results from the Global VOICE project

Author

Midgette, Bria, Strunk, Andrew, Akilov, Oleg, Alavi, Afsaneh, Ardon, Christine, Bechara, Falk G., Cohen, Arnon D., Cohen, Steven, Daveluy, Steven, del Marmol, Véronique, Delage, Maïa, Esmann, Solveig, Fisher, Shani, Giamarellos-Bourboulis, Evangelos J., Glowaczewska, Amelia, Goldfarb, Noah, Brant, Elena Gonzalez, Grimstad, Øystein, Guilbault, Sandra, Hamzavi, Iltefat, Hughes, Rosalind, Ingram, John R., Jemec, Gregor B.E., Ju, Qiang, Kappe, Naomi, Kirby, Brian, Kirby, Joslyn S., Lowes, Michelle A., Matusiak, Lukasz, Micha, Stella, Micheletti, Robert, Miller, Angela P., Moseng, Dagfinn, Naik, Haley, Nassif, Aude, Nikolakis, Georgios, Paek, So Yeon, Pascual, Jose Carlos, Prens, Errol, Resnik, Barry, Riad, Hassan, Sayed, Christopher, Smith, Saxon D., Soliman, Yssra, Szepietowski, Jacek C., Tan, Jerry, Thorlacius, Linnea, Tzellos, Thrasyvoulos, van der Zee, Hessel H., Villumsen, Bente, Wang, Lanqi, Zouboulis, Christos, Garg, Amit, Midgette, Bria, Strunk, Andrew, Akilov, Oleg, Alavi, Afsaneh, Ardon, Christine, Bechara, Falk G., Cohen, Arnon D., Cohen, Steven, Daveluy, Steven, del Marmol, Véronique, Delage, Maïa, Esmann, Solveig, Fisher, Shani, Giamarellos-Bourboulis, Evangelos J., Glowaczewska, Amelia, Goldfarb, Noah, Brant, Elena Gonzalez, Grimstad, Øystein, Guilbault, Sandra, Hamzavi, Iltefat, Hughes, Rosalind, Ingram, John R., Jemec, Gregor B.E., Ju, Qiang, Kappe, Naomi, Kirby, Brian, Kirby, Joslyn S., Lowes, Michelle A., Matusiak, Lukasz, Micha, Stella, Micheletti, Robert, Miller, Angela P., Moseng, Dagfinn, Naik, Haley, Nassif, Aude, Nikolakis, Georgios, Paek, So Yeon, Pascual, Jose Carlos, Prens, Errol, Resnik, Barry, Riad, Hassan, Sayed, Christopher, Smith, Saxon D., Soliman, Yssra, Szepietowski, Jacek C., Tan, Jerry, Thorlacius, Linnea, Tzellos, Thrasyvoulos, van der Zee, Hessel H., Villumsen, Bente, Wang, Lanqi, Zouboulis, Christos, and Garg, Amit

Abstract

Background: Nearly half of patients with hidradenitis suppurativa (HS) report dissatisfaction with their treatment. However, factors related to treatment satisfaction have not been explored. Objectives: To measure associations between treatment satisfaction and clinical and treatment-related characteristics among patients with HS. Methods: Treatment satisfaction was evaluated utilizing data from a cross-sectional global survey of patients with HS recruited from 27 institutions, mainly HS referral centres, in 14 different countries from October 2017 to July 2018. The primary outcome was patients’ self-reported overall satisfaction with their current treatments for HS, rated on a five-point scale from ‘very dissatisfied’ to ‘very satisfied’. Results: The final analysis cohort comprised 1418 patients with HS, most of whom were European (55%, 780 of 1418) or North American (38%, 542 of 1418), and female (85%, 1210 of 1418). Overall, 45% (640 of 1418) of participants were either dissatisfied or very dissatisfied with their current medical treatment. In adjusted analysis, patients primarily treated by a dermatologist for HS had 1·99 [95% confidence interval (CI) 1·62–2·44, P < 0·001] times the odds of being satisfied with current treatment than participants not primarily treated by a dermatologist. Treatment with biologics was associated with higher satisfaction [odds ratio (OR) 2·36, 95% CI 1·74–3·19, P < 0·001] relative to treatment with nonbiologic systemic medications. Factors associated with lower treatment satisfaction included smoking (OR 0·78, 95% CI 0·62–0·99; active vs. never), depression (OR 0·69, 95% CI 0·54–0·87), increasing number of comorbidities (OR 0·88 per comorbidity, 95% CI 0·81–0·96) and increasing flare frequency. Conclusions: There are several factors that appear to positively influence satisfaction with treatment among patients with HS, including treatment by a dermatologist and treatment with a biologic medication. Factors that appear to

Published
2022

24. How to Define Mild to Severe Hidradenitis Suppurativa? A Simple New Tool Based on Latent Class Analysis of EPIVER Data Study

Author

Perrot,Jean-Luc, Maccari,François, Guillem,Philippe, Fougerousse,Anne-Claire, Nassif,Aude, Beneton,Nathalie, Cinotti,Elisa, Girard,Céline, Binois,Raphaelle, Reguiaï,Ziad, Perrot,Jean-Luc, Maccari,François, Guillem,Philippe, Fougerousse,Anne-Claire, Nassif,Aude, Beneton,Nathalie, Cinotti,Elisa, Girard,Céline, Binois,Raphaelle, and Reguiaï,Ziad

Abstract

Jean-Luc Perrot,1,2 François Maccari,2,3 Philippe Guillem,2,4– 6 Anne-Claire Fougerousse,2,7 Aude Nassif,2,8 Nathalie Beneton,2,9 Elisa Cinotti,2,10 Céline Girard,2,11 Raphaelle Binois,2,12 Ziad Reguiaï2,13 On behalf of the ResoVerneuil group1Department of Dermatology, University Hospital of Saint-Etienne, Saint-Etienne, France; 2ResoVerneuil, Ville, France; 3Private Office, La Varenne St Hilaire, France; 4Service de chirurgie adulte, clinique du Val-d’Ouest, Ecully, 69130, France; 5European Hidradenitis Suppurativa Foundation, Dessau, Germany; 6Groupe de Recherche En proctologie de la Société Nationale Francophone de Colo-Proctologie, Paris, France; 7Military Teaching Hospital Bégin, Saint Mandé, France; 8Centre Médical de l’Institut Pasteur, Paris, 75015, France; 9Dermatology Department, Centre Hospitalier du Mans, Le Mans, France; 10Department of Medical, Dermatology Unit, Surgical and Neuro.Sciences, University of Siena, Siena, Italy; 11Dermatology Department, Centre Hospitalier Universitaire de Montpellier, Montpellier, France; 12Dermatology Department, Centre Hospitalier Régional d’Orléans, Orléans Cedex, 45067, France; 13Service de dermatologie, polyclinique Courlancy, Reims, 51100, FranceCorrespondence: Jean-Luc Perrot, Department of Dermatology, University Hospital of Saint-Etienne, Saint-Etienne, France, Email j.luc.perrot@chu-st-etienne.frPurpose: Hidradenitis suppurativa (HS) is an inflammatory skin disease characterized by recurrent or chronic painful and suppurating lesions in the apocrine gland-bearing regions. The lack of knowledge about HS and its extremely heterogeneous clinical presentation, in terms of both lesion appearance and sites of involvement, frequently delay its diagnosis for several years. Objectives: in this study, using the latent class analysis, it was demonstrated that severit

Published
2022

25. Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal a-toxin

Author

MMB, Infection & Immunity, Immuno/reuma patientenzorg, MMB Research line 1, MMB Medische Staf, MS Reumatologie/Immunologie/Infectie, Medische Staf Intensive Care, Spaan, András N., Neehus, Anna Lena, Laplantine, Emmanuel, Staels, Frederik, Ogishi, Masato, Seeleuthner, Yoann, Rapaport, Franck, Lacey, Keenan A., Van Nieuwenhove, Erika, Chrabieh, Maya, Hum, David, Migaud, Mélanie, Izmiryan, Araksya, Lorenzo, Lazaro, Kochetkov, Tatiana, Heesterbeek, Dani A.C., Bardoel, Bart W., DuMont, Ashley L., Dobbs, Kerry, Chardonnet, Solenne, Heissel, Søren, Baslan, Timour, Zhang, Peng, Yang, Rui, Bogunovic, Dusan, Wunderink, Herman F., Haas, Pieter Jan A., Molina, Henrik, Van Buggenhout, Griet, Lyonnet, Stanislas, Notarangelo, Luigi D., Seppänen, Mikko R.J., Weil, Robert, Seminario, Gisela, Gomez-Tello, Héctor, Wouters, Carine, Mesdaghi, Mehrnaz, Shahrooei, Mohammad, Bossuyt, Xavier, Sag, Erdal, Topaloglu, Rezan, Ozen, Seza, Leavis, Helen L., van Eijk, Maarten M.J., Bezrodnik, Liliana, Galicia, Lizbeth Blancas, Hovnanian, Alain, Nassif, Aude, Bader-Meunier, Brigitte, Neven, Bénédicte, Meyts, Isabelle, Schrijvers, Rik, Puel, Anne, Bustamante, Jacinta, Aksentijevich, Ivona, Kastner, Daniel L., Torres, Victor J., Humblet-Baron, Stéphanie, Liston, Adrian, Abel, Laurent, Boisson, Bertrand, Casanova, Jean Laurent, MMB, Infection & Immunity, Immuno/reuma patientenzorg, MMB Research line 1, MMB Medische Staf, MS Reumatologie/Immunologie/Infectie, Medische Staf Intensive Care, Spaan, András N., Neehus, Anna Lena, Laplantine, Emmanuel, Staels, Frederik, Ogishi, Masato, Seeleuthner, Yoann, Rapaport, Franck, Lacey, Keenan A., Van Nieuwenhove, Erika, Chrabieh, Maya, Hum, David, Migaud, Mélanie, Izmiryan, Araksya, Lorenzo, Lazaro, Kochetkov, Tatiana, Heesterbeek, Dani A.C., Bardoel, Bart W., DuMont, Ashley L., Dobbs, Kerry, Chardonnet, Solenne, Heissel, Søren, Baslan, Timour, Zhang, Peng, Yang, Rui, Bogunovic, Dusan, Wunderink, Herman F., Haas, Pieter Jan A., Molina, Henrik, Van Buggenhout, Griet, Lyonnet, Stanislas, Notarangelo, Luigi D., Seppänen, Mikko R.J., Weil, Robert, Seminario, Gisela, Gomez-Tello, Héctor, Wouters, Carine, Mesdaghi, Mehrnaz, Shahrooei, Mohammad, Bossuyt, Xavier, Sag, Erdal, Topaloglu, Rezan, Ozen, Seza, Leavis, Helen L., van Eijk, Maarten M.J., Bezrodnik, Liliana, Galicia, Lizbeth Blancas, Hovnanian, Alain, Nassif, Aude, Bader-Meunier, Brigitte, Neven, Bénédicte, Meyts, Isabelle, Schrijvers, Rik, Puel, Anne, Bustamante, Jacinta, Aksentijevich, Ivona, Kastner, Daniel L., Torres, Victor J., Humblet-Baron, Stéphanie, Liston, Adrian, Abel, Laurent, Boisson, Bertrand, and Casanova, Jean Laurent

Published
2022

27. Bacterial pathogens associated with Hidradenitis Suppurativa, France

Author

Guet-Revillet, Helene, Coignard-Biehler, Helene, Jais, Jean-Philippe, Quesne, Gilles, Frapy, Eric, Poiree, Sylvain, Guern, Anne-Sophie Le, Fleche-Mateos, Anne Le, Hovnanian, Alain, Consigny, Paul- Henry, Lortholary, Olivier, Nassif, Xavier, Nassif, Aude, and Join-Lambert, Olivier

Subjects
Bacteria, Pathogenic -- Health aspects, Virulence (Microbiology) -- Research, Medical research, Medicine, Experimental, Skin diseases -- Causes of, Health
Abstract

Hidradenitis suppurativa (HS), also known as acne inversa and Verneuil disease, is a chronic disease of the apocrine gland-bearing areas of the skin (1). The prevalence of HS is estimated [...]

Published
2014
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29. Low prevalence of gamma-secretase complex gene mutations in a large cohort of predominantly Caucasian patients with Hidradenitis Suppurativa

Author

Duchatelet, Sabine, Miskinyte, Snaigune, Delage, Maia, Ungeheuer, Marie-Noelle, Lam, Thi, Benhadou, Farida, Vossen, Allard R.J. V., Prens, Errol, Cogrel, Olivier, Beylot-Barry, Marie, Girard, Celine, Vidil, Julien, Join-Lambert, Olivier, Parisot, Mélanie, Nitschke, Patrick, Hanein, Sylvain, Fraitag, Sylvie, van Der Zee, Hessel, Bessis, Didier, Damiani, Giovanni, Altomare, Andrea, Liao, Yi-Hua, Nikolakis, Georgios, Zouboulis, Christos, Nassif, Aude, Hovnanian, Alain, Genetic skin diseases : from disease mechanism to therapies (Equipe Inserm U1163), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Centre Médical de l'Institut Pasteur (CMIP), Institut Pasteur [Paris], Investigation Clinique et d’Accès aux Ressources Biologiques (Plate-forme) - Clinical Investigation and Access to BioResources (ICAReB), Hôpital Erasme [Bruxelles] (ULB), Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Service de dermatologie [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Laboratoire de Microbiologie [AP-HP Necker], Université Paris Descartes - Paris 5 (UPD5)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Microbiologie [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Structure Fédérative de Recherche Necker (SFR Necker - UMS 3633 / US24), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Medizinische Hochschule Brandenburg Theodor Fontane / Brandenburg Medical School Theodor-Fontane (MHB Theodor Fontane), Centre Médical de l'Institut Pasteur, Nassif, Aude, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Institut Pasteur [Paris] (IP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)

Subjects
[SDV] Life Sciences [q-bio], [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, [SDV]Life Sciences [q-bio], [SDV.MHEP.DERM] Life Sciences [q-bio]/Human health and pathology/Dermatology, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology
Abstract

9TH CONFERENCE OF THE EUROPEAN HIDRADENITIS SUPPURATIVA FOUNDATION - ATHENS; International audience

Published
2020
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32. Hidradénite suppurée : évaluation des pratiques des dermatologues à la suite de la publication des recommandations françaises

Author

Fottorino, Antoine, primary, Prouteau, Constance, additional, Balland, Christelle, additional, Villani, Axel, additional, Buche, Sébastien, additional, Hotz, Claire, additional, Delage, Maïa, additional, Cogrel, Olivier, additional, Nassif, Aude, additional, Jouan, Nicole, additional, and Richard, Marie-Aleth, additional

Published
2021
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33. Collaborateurs

Author

Abbès, Leila, Alam, Amine Antonin, Angliviel, Benjamin, Aubert, Manuel, Hamed, Nabil Baba, Barré, Amélie, Benfredj, Paul, Chanal, Johan, Crétolle, Célia, Cristea, Cosmin, de Bonnechose, Grégoire, Draullette, Mélanie, Fathallah, Nadia, Haouari, Mohamed Amine, Kassouri, Liza, Le Baleur, Yann, Lefevre, Jérémie, Lourtet-Hascoët, Julie, Marcin, Kennie, Marone, Dior, Nassif, Aude, de Parades, Vincent, Pastier, Clément, Pigneur, Bénédicte, Pigot, François, Pommaret, Elise, Roland, Déborah, Far, Eric Safa, Spindler, Lucas, Thierry, Marie-Lise, Vitton, Véronique, Uzzan, Mathieu, and Zeitoun, Jean-David

Published
2024
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35. Low Prevalence of GSC Gene Mutations in a Large Cohort of Predominantly Caucasian Patients with Hidradenitis Suppurativa

Author

Duchatelet, Sabine, Miskinyte, Snaigune, Delage, Maia, Ungeheuer, Marie-Noëlle, Lam, Thi, Benhadou, Farida, Del Marmol, Véronique, Vossen, Allard R.J.V., Prens, Errol P., Cogrel, Olivier, Beylot-Barry, Marie, Girard, Céline, Vidil, Julien, Join-Lambert, Olivier, Parisot, Mélanie, Nitschké, Patrick, Hanein, Sylvain, Fraitag, Sylvie, Van der Zee, Hessel H., Bessis, Didier, Damiani, Giovanni, Altomare, Andrea, Liao, Yi-Hua, Nikolakis, Georgios, Zouboulis, Christos C., Nassif, Aude, and Hovnanian, Alain

Published
2020
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37. Remission of chronic acne fulminans and severe hidradenitis suppurativa with targeted antibiotherapy [case report]

Author

Duchatelet, Sabine, Join-Lambert, Olivier, Delage, Maïa, Miskinyte, Snaigune, Guet-Revillet, Hélène, Coignard-Biehler, Hélène, Ungeheuer, Marie-Noëlle, Chatenoud, Lucienne, Lortholary, Olivier, Nassif, Xavier, Hovnanian, Alain, Nassif, Aude Sophie, Genetic skin diseases : from disease mechanism to therapies (Equipe Inserm U1163), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Laboratoire de Microbiologie Clinique [AP-HP Hôpital Necker-Enfants Malades], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Microbiologie [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Groupe de Recherche sur l'Adaptation Microbienne (GRAM 2.0), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), Centre Médical de l'Institut Pasteur (CMIP), Institut Pasteur [Paris], Service des Maladies infectieuses et tropicales [CHU Necker], Investigation Clinique et d’Accès aux Ressources Biologiques (Plate-forme) - Clinical Investigation and Access to BioResources (ICAReB), Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Fondation pour la Recherche Méedicale through Roxane funding, the French Society of Dermatology, and the French Patients’ Association for Research in HS, Centre Médical de l'Institut Pasteur, Nassif, Aude, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Institut Pasteur [Paris] (IP), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)

Subjects
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, treatment, interleukin, host-microbiome disease, tumor necrosis factor, [SDV]Life Sciences [q-bio], hidradenitis suppurativa, TNF, IL, bacterial metagenomics, [SDV.MHEP.DERM] Life Sciences [q-bio]/Human health and pathology/Dermatology, AF, cytokines, [SDV] Life Sciences [q-bio], HS, remission, genetics, antibiotherapy, acne fulminans, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology
Abstract

International audience

Published
2019
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38. The Microbiology of suppurative Pilonidal Sinus Disease: another link with Hidradenitis Suppurativa

Author

Guet-Revillet, H., Delage, Maïa, Riverain-Gillet, É, Jais, J-P, Ungeheueur, M-N, Consigny, P-H, Lemarchand, N., De Parades, V., Nassif, Aude, Join-Lambert, O., Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre Médical de l'Institut Pasteur (CMIP), Institut Pasteur [Paris] (IP), Centre Hospitalier François Quesnay, Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Centre hospitalier Saint-Joseph [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Groupe de Recherche sur l'Adaptation Microbienne (GRAM 2.0), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse], Institut Pasteur [Paris], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Université de Caen Normandie (UNICAEN), Mzembaba, Sandy, and Centre Médical de l'Institut Pasteur

Subjects
[SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

39. Metabolic alterations in Hurley stage 1 Hidradenitis Suppurativa

Author

Delage, Maïa, Guenin-Macé, Laure, Morel, Jean-David, Doisne, Jean-Marc, Schiavo, Angèle, Ungeheuer, Marie-Noëlle, Lam, Thi, Join-Lambert, Olivier, Santo, James, Nassif, Aude, Demangel, Caroline, Centre Médical de l'Institut Pasteur, Institut Pasteur [Paris], Immunobiologie de l'Infection - Immunobiology of Infection, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Immunité Innée - Innate Immunity, Investigation Clinique et d’Accès aux Ressources Biologiques (Plate-forme) - Clinical Investigation and Access to BioResources (ICAReB), Service de Microbiologie [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Groupe de Recherche sur l'Adaptation Microbienne (GRAM 2.0), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), Centre Médical de l'Institut Pasteur (CMIP), Institut Pasteur [Paris] (IP), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Mzembaba, Sandy, and Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur [Paris]

Subjects
[SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

43. Baseline Characteristics of a National French E-Cohort of Hidradenitis Suppurativa in ComPaRe and Comparison with Other Large Hidradenitis Suppurativa Cohorts

Author

Condamina, Morgane, primary, Penso, Laetitia, additional, Tran, Viet-Thi, additional, Hotz, Claire, additional, Guillem, Philippe, additional, Villani, Axel Patrice, additional, Perrot, Pierre, additional, Bru, Marie-France, additional, Jacquet, Eric, additional, Nassif, Aude, additional, Bachelez, Hervé, additional, Wolkenstein, Pierre, additional, Beylot-Barry, Marie, additional, Richard, Marie-Aleth, additional, Ravaud, Philippe, additional, Viguier, Manuelle, additional, and Sbidian, Emilie, additional

Published
2021
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45. What causes hidradenitis suppurativa ?—15 years after

Author

Zouboulis, Christos C., primary, Benhadou, Farida, additional, Byrd, Angel S., additional, Chandran, Nisha S., additional, Giamarellos‐Bourboulis, Evangelos J., additional, Fabbrocini, Gabriella, additional, Frew, John W., additional, Fujita, Hideki, additional, González‐López, Marcos A., additional, Guillem, Philippe, additional, Gulliver, Wayne P. F., additional, Hamzavi, Iltefat, additional, Hayran, Yildiz, additional, Hórvath, Barbara, additional, Hüe, Sophie, additional, Hunger, Robert E., additional, Ingram, John R., additional, Jemec, Gregor B.E., additional, Ju, Qiang, additional, Kimball, Alexa B., additional, Kirby, Joslyn S., additional, Konstantinou, Maria P., additional, Lowes, Michelle A., additional, MacLeod, Amanda S., additional, Martorell, Antonio, additional, Marzano, Angelo V., additional, Matusiak, Łukasz, additional, Nassif, Aude, additional, Nikiphorou, Elena, additional, Nikolakis, Georgios, additional, Nogueira da Costa, André, additional, Okun, Martin M., additional, Orenstein, Lauren A.V., additional, Pascual, José Carlos, additional, Paus, Ralf, additional, Perin, Benjamin, additional, Prens, Errol P., additional, Röhn, Till A., additional, Szegedi, Andrea, additional, Szepietowski, Jacek C., additional, Tzellos, Thrasyvoulos, additional, Wang, Baoxi, additional, and van der Zee, Hessel H., additional

Published
2020
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46. Dysregulation of tryptophan catabolism at the host-skin microbiota interface in hidradenitis suppurativa

Author

Guenin-Macé, Laure, primary, Morel, Jean-David, additional, Doisne, Jean-Marc, additional, Schiavo, Angèle, additional, Boulet, Lysiane, additional, Mayau, Véronique, additional, Goncalves, Pedro, additional, Duchatelet, Sabine, additional, Hovnanian, Alain, additional, Bondet, Vincent, additional, Duffy, Darragh, additional, Ungeheuer, Marie-Noëlle, additional, Delage, Maïa, additional, Nassif, Aude, additional, Di Santo, James P., additional, and Demangel, Caroline, additional

Published
2020
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48. Clinical characteristics of pediatric hidradenitis suppurativa:a cross-sectional multicenter study of 140 patients

Author

Riis, Peter Theut, Saunte, Ditte Marie, Sigsgaard, Viktoria, Villani, Axel Patrice, Guillem, Philippe, Pascual, José C., Kappe, Naomi N., Vanlaerhoven, Annika M.J.D., van der Zee, Hessel H., Prens, Errol P., El-Domyati, Moetaz, Abdel-Wahab, Hossam, Moftah, Nayera, Abdelghani, Rania, Agut-Busquet, Eugenia, Romaní, Jorge, Hlela, Carol, van den Worm, Lerinza, Bettoli, Vincenzo, Calamo, Giada, Gürer, Mehmet Ali, Beksaç, Burcu, Matusiak, Lukasz, Glowaczewska, Amelia, Szepietowski, Jacek C., Emtestam, Lennart, Lapins, Jan, Kottb, Hassan Riad, Fatani, Mohammad, Weibel, Lisa, Theiler, Martin, Delage-Toriel, Maïa, Lam, Thi Thanh Hong, Nassif, Aude, Becherel, Pierre Andre, Dolenc-Voljc, Mateja, Doss, Nejib, Bouazzi, Dorra, Benhadou, Farida, del Marmol, Veronique, Jemec, Gregor B.E., Riis, Peter Theut, Saunte, Ditte Marie, Sigsgaard, Viktoria, Villani, Axel Patrice, Guillem, Philippe, Pascual, José C., Kappe, Naomi N., Vanlaerhoven, Annika M.J.D., van der Zee, Hessel H., Prens, Errol P., El-Domyati, Moetaz, Abdel-Wahab, Hossam, Moftah, Nayera, Abdelghani, Rania, Agut-Busquet, Eugenia, Romaní, Jorge, Hlela, Carol, van den Worm, Lerinza, Bettoli, Vincenzo, Calamo, Giada, Gürer, Mehmet Ali, Beksaç, Burcu, Matusiak, Lukasz, Glowaczewska, Amelia, Szepietowski, Jacek C., Emtestam, Lennart, Lapins, Jan, Kottb, Hassan Riad, Fatani, Mohammad, Weibel, Lisa, Theiler, Martin, Delage-Toriel, Maïa, Lam, Thi Thanh Hong, Nassif, Aude, Becherel, Pierre Andre, Dolenc-Voljc, Mateja, Doss, Nejib, Bouazzi, Dorra, Benhadou, Farida, del Marmol, Veronique, and Jemec, Gregor B.E.

Abstract

Hidradenitis suppurativa (HS) rarely affects pediatric patients. The literature on pediatric HS patients is scarce. This is a cross-sectional study based on case note review or interviews and clinical examination of 140 pediatric patients undergoing secondary or tertiary level care. Patients were predominantly female (75.5%, n = 105) with a median age of 16. 39% reported 1st-degree relative with HS. Median BMI percentile was 88, and 11% were smokers (n = 15). Median modified Sartorius score was 8.5. Notable comorbidities found were acne (32.8%, n = 45), hirsutism (19.3%, n = 27), and pilonidal cysts (16.4%, n = 23). Resorcinol (n = 27) and clindamycin (n = 25) were the most frequently used topical treatments. Patients were treated with tetracycline (n = 32), or oral clindamycin and rifampicin in combination (n = 29). Surgical excision was performed in 18 patients, deroofing in five and incision in seven patients. Obesity seemed to be prominent in the pediatric population and correlated to parent BMI, suggesting a potential for preventive measures for the family. Disease management appeared to be similar to that of adult HS, bearing in mind that the younger the patient, the milder the disease in majority of cases.

Published
2020

49. What causes hidradenitis suppurativa ?-15 years after.

Author

Zouboulis, Christos C.C., Benhadou, Farida, Byrd, Angel AS, Chandran, Nisha NS, Giamarellos-Bourboulis, Evangelos J, Fabbrocini, Gabriella, Frew, John JW, Fujita, Hideki, González-López, Marcos MA, Guillem, Philippe, Gulliver, Wayne WPF, Hamzavi, Iltefat, Hayran, Yildiz, Hórvath, Barbara, Hüe, Sophie, Hunger, Robert RE, Ingram, John Robert, Jemec, Gregor B E, Ju, Qiang, Kimball, Alexa AB, Kirby, Joslyn Sciacca, Konstantinou, Maria MP, Lowes, Michelle MA, MacLeod, Amanda S, Martorell, Antonio, Marzano, Angelo V, Matusiak, Łukasz L., Nassif, Aude, Nikiphorou, Elena, Nikolakis, Georgios, Nogueira da Costa, André, Okun, Martin MM, Orenstein, Lauren LAV, Pascual, José Carlos, Paus, Ralf, Perin, Benjamin, Prens, Errol E.P., Röhn, Till TA, Szegedi, Andrea, Szepietowski, Jacek C, Tzellos, Thrasyvoulos, Wang, Baoxi, van der Zee, Hessel H, Zouboulis, Christos C.C., Benhadou, Farida, Byrd, Angel AS, Chandran, Nisha NS, Giamarellos-Bourboulis, Evangelos J, Fabbrocini, Gabriella, Frew, John JW, Fujita, Hideki, González-López, Marcos MA, Guillem, Philippe, Gulliver, Wayne WPF, Hamzavi, Iltefat, Hayran, Yildiz, Hórvath, Barbara, Hüe, Sophie, Hunger, Robert RE, Ingram, John Robert, Jemec, Gregor B E, Ju, Qiang, Kimball, Alexa AB, Kirby, Joslyn Sciacca, Konstantinou, Maria MP, Lowes, Michelle MA, MacLeod, Amanda S, Martorell, Antonio, Marzano, Angelo V, Matusiak, Łukasz L., Nassif, Aude, Nikiphorou, Elena, Nikolakis, Georgios, Nogueira da Costa, André, Okun, Martin MM, Orenstein, Lauren LAV, Pascual, José Carlos, Paus, Ralf, Perin, Benjamin, Prens, Errol E.P., Röhn, Till TA, Szegedi, Andrea, Szepietowski, Jacek C, Tzellos, Thrasyvoulos, Wang, Baoxi, and van der Zee, Hessel H

Abstract

The 14 authors of the first review article on hidradenitis suppurativa (HS) pathogenesis published 2008 in EXPERIMENTAL DERMATOLOGY cumulating from the 1st International Hidradenitis Suppurativa Research Symposium held March 30-April 2, 2006 in Dessau, Germany with 33 participants were prophetic when they wrote "Hopefully, this heralds a welcome new tradition: to get to the molecular heart of HS pathogenesis, which can only be achieved by a renaissance of solid basic HS research, as the key to developing more effective HS therapy." (Kurzen et al. What causes hidradenitis suppurativa? Exp Dermatol 2008;17:455). Fifteen years later, there is no doubt that the desired renaissance of solid basic HS research is progressing with rapid steps and that HS has developed deep roots among inflammatory diseases in Dermatology and beyond, recognized as "the only inflammatory skin disease than can be healed". This anniversary article of 43 research-performing authors from all around the globe in the official journal of the European Hidradenitis Suppurativa Foundation e.V. (EHSF e.V.) and the Hidradenitis Suppurativa Foundation, Inc (HSF USA) summarizes the evidence of the intense HS clinical and experimental research during the last 15 years in all aspects of the disease and provides information of the developments to come in the near future., SCOPUS: re.j, info:eu-repo/semantics/published

Published
2020

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