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IntroductionThe Covid-19 pandemic is disrupting normal life globally. The COVID-19 pandemic is an emerging concern regarding the potential effects during breastfeeding. The aim of this study was to conduct a systemic review of mother-to -child transmission of COVID-19 during breastfeeding.MethodThis study systematically searched electronic databases; google scholar, PubMed, Medline, up December 2020. The study was included studies relevant to transmission breast milk and respiratory droplets during breastfeeding of mothers with COVID-19 positive. To identify the quality of data, prism standard was used and Strobe checklist scale.ResultA total of 3160 records were identified in this systemic review with eight relevant studies involving 159 mothers (63 mothers with COVID-19 positive, 55 of their breast milk samples tested negative for the-Covid-19. Twenty-one breast milk samples from 8 women tested positive for Covid-19. Of 73 infants were born to mothers with COVID-19 at the time of delivery. Two infants tested positive for Covid-19. The average mother-child separation time was 36•7 ± 21•1 days among mothers confirmed with COVID-19. Out of 22 mothers, ((37.5%) chose to breastfeed their babies after confirm covid-19 positive.ConclusionThis study shown that breastfeeding practices were extremely impacted during the COVID-19 epidemic among both confirmed positive cases and suspected mothers. However, the risk of mother-to-infant transmission of Covid-19 vertically or horizontally, in the perinatal period is very low.