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1. High tumor mutational burden assessed through next-generation sequencing predicts favorable survival in microsatellite stable metastatic colon cancer patients

Author

Di Mauro, Annabella, Santorsola, Mariachiara, Savarese, Giovanni, Sirica, Roberto, Ianniello, Monica, Cossu, Alessia Maria, Ceccarelli, Anna, Sabbatino, Francesco, Bocchetti, Marco, Carratù, Anna Chiara, Pentimalli, Francesca, Ferrara, Gerardo, Nasti, Guglielmo, Caraglia, Michele, and Ottaiano, Alessandro

Published
2024
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2. Predictive significance of FGFR4 p.G388R polymorphism in metastatic colorectal cancer patients receiving trifluridine/tipiracil (TAS-102) treatment

Author

Ottaiano, Alessandro, Santorsola, Mariachiara, Ianniello, Monica, Ceccarelli, Anna, Casillo, Marika, Sabbatino, Francesco, Petrillo, Nadia, Cascella, Marco, Caraglia, Francesco, Picone, Carmine, Perri, Francesco, Sirica, Roberto, Zappavigna, Silvia, Nasti, Guglielmo, Savarese, Giovanni, and Caraglia, Michele

Published
2024
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4. Intermittent or Continuous Panitumumab Plus Fluorouracil, Leucovorin, and Irinotecan for First-Line Treatment of RAS and BRAF Wild-Type Metastatic Colorectal Cancer: The IMPROVE Trial

Author

Avallone, Antonio, Giuliani, Francesco, De Stefano, Alfonso, Santabarbara, Giuseppe, Nasti, Guglielmo, Montesarchio, Vincenzo, Rosati, Gerardo, Cassata, Antonino, Leo, Silvana, Romano, Carmela, Tamburini, Emiliano, Silvestro, Lucrezia, Lotesoriere, Claudio, Nappi, Anna, Santini, Daniele, Petrillo, Antonella, Colombo, Alfredo, Febbraro, Antonio, Leone, Alessandra, Mannavola, Francesco, Laterza, Maria Maddalena, Izzo, Francesco, Sobrero, Alberto, Delrio, Paolo, Giannarelli, Diana, and Budillon, Alfredo

Published
2024
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5. Clinical and genetic drivers of oligo-metastatic disease in colon cancer

Author

Ottaiano, Alessandro, Santorsola, Mariachiara, Sirica, Roberto, Mauro, Annabella Di, Di Carlo, Antonella, Ianniello, Monica, Sabbatino, Francesco, Castiello, Rosa, Peschio, Francesca Del, Cascella, Marco, Perri, Francesco, Capuozzo, Maurizio, Martucci, Nicola, Mercadante, Edoardo, Borzillo, Valentina, Di Franco, Rossella, Izzo, Francesco, Granata, Vincenza, Picone, Carmine, Petrillo, Antonella, Berretta, Massimiliano, Stilo, Salvatore, Tarotto, Luca, Carratù, Anna Chiara, Ferrara, Gerardo, Tathode, Madhura, Cossu, Alessia Maria, Bocchetti, Marco, Caraglia, Michele, Nasti, Guglielmo, and Savarese, Giovanni

Published
2025
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7. Oligo-metastatic neoPlasms from the gastro-intestinal tract: iDentIfiCaTIon of cliNical and molecular drivers: the PREDICTION study

Author

Ottaiano, Alessandro, De Luca, Antonella, Santorsola, Mariachiara, Scognamiglio, Giosuè, Di Mauro, Annabella, Chiodini, Paolo, Lambiase, Matilde, Sacco, Alessandra, Petrillo, Antonella, Granata, Vincenza, Fusco, Roberta, Mercadante, Edoardo, Martucci, Nicola, De Luca, Giuseppe, Rocca, Antonello La, Celentano, Egidio, Crispo, Anna, Di Gennaro, Piergiacomo, Tatangelo, Fabiana, Ferrara, Gerardo, Izzo, Francesco, Belli, Andrea, Patrone, Renato, Delrio, Paolo, Rega, Daniela, De Franciscis, Silvia, Muto, Paolo, Ravo, Vincenzo, Di Franco, Rossella, Borzillo, Valentina, Santagata, Sara, Rea, Giuseppina, Castaldo, Daniela, Pace, Ugo, De Feo, Gianfranco, Scala, Stefania, Nasti, Guglielmo, and Normanno, Nicola

Published
2023
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12. Radiomics and machine learning analysis based on magnetic resonance imaging in the assessment of liver mucinous colorectal metastases

Author

Granata, Vincenza, Fusco, Roberta, De Muzio, Federica, Cutolo, Carmen, Setola, Sergio Venanzio, Dell’Aversana, Federica, Grassi, Francesca, Belli, Andrea, Silvestro, Lucrezia, Ottaiano, Alessandro, Nasti, Guglielmo, Avallone, Antonio, Flammia, Federica, Miele, Vittorio, Tatangelo, Fabiana, Izzo, Francesco, and Petrillo, Antonella

Published
2022
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13. Intermittent or Continuous Panitumumab Plus Fluorouracil, Leucovorin, and Irinotecan for First-Line Treatment of RAS and BRAF Wild-Type Metastatic Colorectal Cancer: The IMPROVE Trial.

Author

Avallone, Antonio, Giuliani, Francesco, De Stefano, Alfonso, Santabarbara, Giuseppe, Nasti, Guglielmo, Montesarchio, Vincenzo, Rosati, Gerardo, Cassata, Antonino, Leo, Silvana, Romano, Carmela, Tamburini, Emiliano, Silvestro, Lucrezia, Lotesoriere, Claudio, Nappi, Anna, Santini, Daniele, Petrillo, Antonella, Colombo, Alfredo, Febbraro, Antonio, Leone, Alessandra, and Mannavola, Francesco

Published
2025
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20. Multicenter Single-Arm, Two-Stage Phase 2 Study of Panitumumab in Patients With Cetuximab-Refractory Metastatic Colorectal Cancer: The PACER Trial

Author

Piccirillo, Maria Carmela, Avallone, Antonio, Carlomagno, Chiara, Maiello, Evaristo, Rosati, Gerardo, Alabiso, Oscar, Nasti, Guglielmo, De Placido, Sabino, Latiano, Tizana Pia, Bilancia, Domenico, Ottaiano, Alessandro, De Stefano, Alfonso, Romano, Carmela, Silvestro, Lucrezia, Nappi, Anna, Cassata, Antonino, Giordano, Pasqualina, Iaffaioli, Rosario Vincenzo, Normanno, Nicola, Perrone, Francesco, and Daniele, Bruno

Published
2020
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21. Treatments, prognostic factors, and genetic heterogeneity in advanced cholangiocarcinoma: A multicenter real‐world study

Author

Ottaiano, Alessandro, primary, Santorsola, Mariachiara, additional, Diana, Anna, additional, Belli, Andrea, additional, Lentini Graziano, Maria Luisa, additional, Orefice, Jessica, additional, Patrone, Renato, additional, Di Mauro, Annabella, additional, Scognamiglio, Giosuè, additional, Tatangelo, Fabiana, additional, De Bellis, Mario, additional, Piccirillo, Mauro, additional, Fiore, Francesco, additional, Stilo, Salvatore, additional, Tarotto, Luca, additional, Correra, Marco, additional, Di Lorenzo, Sara, additional, Capuozzo, Maurizio, additional, Avallone, Antonio, additional, Silvestro, Lucrezia, additional, Bianco, Antonella, additional, Granata, Vincenza, additional, Federico, Piera, additional, Montesarchio, Vincenzo, additional, Daniele, Bruno, additional, Izzo, Francesco, additional, and Nasti, Guglielmo, additional

Published
2024
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22. Exploring the Spectrum of VEGF Inhibitors’ Toxicities from Systemic to Intra-Vitreal Usage in Medical Practice

Author

Santorsola, Mariachiara, primary, Capuozzo, Maurizio, additional, Nasti, Guglielmo, additional, Sabbatino, Francesco, additional, Di Mauro, Annabella, additional, Di Mauro, Giordana, additional, Vanni, Gianluca, additional, Maiolino, Piera, additional, Correra, Marco, additional, Granata, Vincenza, additional, Gualillo, Oreste, additional, Berretta, Massimiliano, additional, and Ottaiano, Alessandro, additional

Published
2024
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24. Oligo-Metastatic Disease in Oncology: Exploring the Limits and the Potential of Genetic Assessment

Author

Santorsola, Mariachiara, primary, Capuozzo, Maurizio, additional, Savarese, Giovanni, additional, Ianniello, Monica, additional, Petrillo, Nadia, additional, Casillo, Marika, additional, Sabbatino, Francesco, additional, Perri, Francesco, additional, Ferrara, Francesco, additional, Zovi, Andrea, additional, Berretta, Massimiliano, additional, Granata, Vincenza, additional, Nasti, Guglielmo, additional, and Ottaiano, Alessandro, additional

Published
2023
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25. BRAF p.V600E mutation as a molecular boundary between genuine oligo-repeated and poly-metastatic disease in colorectal cancer

Author

Ottaiano, Alessandro, primary, Santorsola, Mariachiara, additional, Circelli, Luisa, additional, Ianniello, Monica, additional, Casillo, Marika, additional, Petrillo, Nadia, additional, Sabbatino, Francesco, additional, Cascella, Marco, additional, Perri, Francesco, additional, Capuozzo, Maurizio, additional, Albino, Vittorio, additional, Granata, Vincenza, additional, Izzo, Francesco, additional, Di Mauro, Annabella, additional, Berretta, Massimiliano, additional, Ruggiero, Raffaella, additional, Gualillo, Oreste, additional, Sirica, Roberto, additional, Nasti, Guglielmo, additional, and Savarese, Giovanni, additional

Published
2023
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26. Treatment sequence with either irinotecan/cetuximab followed by FOLFOX-4 or the reverse strategy in metastatic colorectal cancer patients progressing after first-line FOLFIRI/bevacizumab: An Italian Group for the Study of Gastrointestinal Cancer phase III, randomised trial comparing two sequences of therapy in colorectal metastatic patients

Author

Cascinu, Stefano, Rosati, Gerardo, Bilancia, Domenico, Nasti, Guglielmo, Iaffaioli, Rosario Vincenzo, Lonardi, Sara, Zagonel, Vittorina, Zaniboni, Alberto, Marchetti, Paolo, Romiti, Adriana, Leone, Francesco, Aglietta, Massimo, Giordano, Monica, Corsi, Domenico C., Ferraú, Francesco, Labianca, Roberto, Mosconi, Stefania, Ronzoni, Monica, Gianni, Luca, Rulli, Eliana, Poli, Davide, Galli, Francesca, Torri, Valter, De Simone, Irene, Galli, Fabio, Pasini, Felice, Rangoni, Giovanni, Venezia, Raffaele, Sozzi, Pietro, Nuzzo, Antonio, Berardi, Rossana, Frontini, Luciano, Rota, Silvia, Cozzi, Lorena, and Scartozzi, Mario

Published
2017
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31. From Chaos to Opportunity: Decoding Cancer Heterogeneity for Enhanced Treatment Strategies

Author

Ottaiano, Alessandro, primary, Ianniello, Monica, additional, Santorsola, Mariachiara, additional, Ruggiero, Raffaella, additional, Sirica, Roberto, additional, Sabbatino, Francesco, additional, Perri, Francesco, additional, Cascella, Marco, additional, Di Marzo, Massimiliano, additional, Berretta, Massimiliano, additional, Caraglia, Michele, additional, Nasti, Guglielmo, additional, and Savarese, Giovanni, additional

Published
2023
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32. Cetuximab continuation after first progression in metastatic colorectal cancer (CAPRI-GOIM): a randomized phase II trial of FOLFOX plus cetuximab versus FOLFOX

Author

Iaffaioli, Vincenzo, Nasti, Guglielmo, Botti, Gerardo, Tatangelo, F., Chicchinelli, Nicoletta, Montrone, Mirko, Sebastio, Annamaria, Guarino, Tiziana, Simone, Gianni, Graziano, Paolo, Chiarazzo, Cinzia, Di Maggio, Gabriele, Longhitano, Laura, Manusia, Mario, Cartenì, Giacomo, Nappi, Oscar, Micheli, Pietro, Leo, Luigi, Rossi, Sabrina, Cassano, Alessandra, Tommaselli, Eugenio, Giordano, Guido, Sponziello, Francesco, Marino, Antonella, Rinaldi, Antonio, Romito, Sante, Muda, Andrea Onetti, Lorusso, Vito, Leo, Silvana, Barni, Sandro, Grimaldi, Giuseppe, Aieta, Michele, Ciardiello, F., Normanno, N., Martinelli, E., Troiani, T., Pisconti, S., Cardone, C., Nappi, A., Bordonaro, A.R., Rachiglio, M., Lambiase, M., Latiano, T.P., Modoni, G., Cordio, S., Giuliani, F., Biglietto, M., Montesarchio, V., Barone, C., Tonini, G., Cinieri, S., Febbraro, A., Rizzi, D., De Vita, F., Orditura, M., Colucci, G., and Maiello, E.

Published
2016
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33. Hypertension, type 2 diabetes, obesity, and p53 mutations negatively correlate with metastatic colorectal cancer patients’ survival

Author

Ottaiano, Alessandro, Santorsola, Mariachiara, Circelli, Luisa, Perri, Francesco, Cascella, Marco, Sabbatino, Francesco, Capuozzo, Maurizio, Granata, Vincenza, Zappavigna, Silvia, Lombardi, Angela, Scrima, Marianna, Petrillo, Nadia, Ianniello, Monica, Casillo, Marika, Gualillo, Oreste, Nasti, Guglielmo, Caraglia, Michele, Savarese, Giovanni, Ottaiano, Alessandro, Santorsola, Mariachiara, Circelli, Luisa, Perri, Francesco, Cascella, Marco, Sabbatino, Francesco, Capuozzo, Maurizio, Granata, Vincenza, Zappavigna, Silvia, Lombardi, Angela, Scrima, Marianna, Petrillo, Nadia, Ianniello, Monica, Casillo, Marika, Gualillo, Oreste, Nasti, Guglielmo, Caraglia, Michele, and Savarese, Giovanni

Subjects
p53, obesity, hypertension, NGS, metastatic colorectal cancer, prognosis, type 2 diabetes, General Medicine, prognosi
Abstract

IntroductionWe studied the predictive and prognostic influences of hypertension (HT), type 2 diabetes (T2D), weight, and p53 mutations in metastatic colorectal cancer (CRC) patients.Patients and methodsT2D was diagnosed according to the ADA criteria. HT was classified according to the ACC/AHA guidelines. BMI (body-mass index) was calculated and classified according to the WHO criteria. TruSigt™Oncology 500 kit was applied to construct the genomic libraries for Next Generation Sequencing (NGS) analysis. The Illumina NovaSeq 6000 technological platform and the Illumina TruSight Oncology 500 bioinformatics pipeline were applied to analyze results. Overall survival (OS) was calculated through Kaplan-Meier curves. Univariate and multivariate analyses were performed to assess the relationships between clinical and/or molecular covariates. Associations between HT, T2D, BMI, p53, and clinical variables were evaluated by the χ2 test. P < 0.05 were considered statistically significant.ResultsTwo-hundred-forty-four patients were enrolled. One-hundred-twenty (49.2%), 110 (45.1%), and 50 (20.5%) patients were affected by overweight, HT, and T2D, respectively. DC (disease control) was achieved more frequently in patients without T2D (83.1%) compared to the diabetic ones (16.9%) (P = 0.0246). DC, KRAS mutational status, T2D, BMI, and concomitant presence of T2D, BMI, and HT associated with survival (P < 0.05). At multivariate analysis, age (≥65 vs. P = 0.0217) emerged as independent prognostic variables. P53 was mutated in 31/53 analyzed cases (60.4%). The most frequent gene variants were p.Arg175His and p.Cys135Tyr. High BMI (>25 kg/m2) associated with occurrence of p53 mutations (P < 0.0001). P53 mutated patients presented a worse prognosis compared to the wild-type ones (HR: 3.21; 95% CI: 1.43–7.23; P = 0.0047).ConclusionDiabetic, hypertensive and overweight metastatic CRC patients are a negative prognostic subgroup deserving specific therapeutic strategies. P53 mutations associate with prognosis and BMI unrevealing complex and unexplored connections between metabolism and cancer occurrence.

Published
2023
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34. Circulating Vitamin D Level and Its Impact on Mortality and Recurrence in Stage III Colorectal Cancer Patients: A Systematic Review and Meta-Analysis

Author

Ottaiano, Alessandro, Facchini, Sergio, Santorsola, Mariachiara, Nasti, Guglielmo, Facchini, Gaetano, Montella, Liliana, Maurea, Nicola, Cascella, Marco, Iervolino, Domenico, Facchini, Bianca Arianna, Montopoli, Monica, Consolo, Pierluigi, Quagliariello, Vincenzo, Rinaldi, Luca, Berretta, Massimiliano, Ottaiano, Alessandro, Facchini, Sergio, Santorsola, Mariachiara, Nasti, Guglielmo, Facchini, Gaetano, Montella, Liliana, Maurea, Nicola, Cascella, Marco, Iervolino, Domenico, Facchini, Bianca Arianna, Montopoli, Monica, Consolo, Pierluigi, Quagliariello, Vincenzo, Rinaldi, Luca, and Berretta, Massimiliano

Subjects
disease-free survival, colorectal cancer, vitamin D, prognosis, survival, prognosi
Abstract

Background: Vitamin D (VD) has been implicated in several diseases, including colorectal cancer (CRC). This study aimed to determine whether there is an association between VD levels and time-to-outcome in stage III CRC patients through a systematic review and meta-analysis. Methods: The study adhered to the PRISMA 2020 statement. Articles were searched in PubMed/MEDLINE and Scopus/ELSEVIER. Four articles were selected, with the primary objective of providing a pooled estimate of the risk of death specifically in stage III CRC patients based on pre-operative VD levels. Study heterogeneity and publication bias were analyzed using Tau2 statistics and funnel plots. Results: The selected studies showed significant heterogeneity regarding time-to-outcome, technical assessments, and serum VD concentration measures. The pooled analysis of 2628 and 2024 patients revealed a 38% and 13% increase in the risk of death (HR: 1.38, 95% CI: 0.71-2.71) and recurrence (HR: 1.13; 95% CI: 0.84-1.53), respectively, for random-effects models among patients with lower levels of VD. Conclusions: Our findings suggest that a low concentration of VD has a significant negative impact on time-to-outcome in stage III CRC.

Published
2023

35. Clinical activity and tolerability of FOLFIRI and cetuximab in elderly patients with metastatic colorectal cancer in the CAPRI-GOIM first-line trial

Author

Martinelli, E., Cardone, C., Troiani, T., Normanno, N., Pisconti, S., Sforza, V., Bordonaro, A.R., Rachiglio, A.M., Lambiase, M., Latiano, T.P., Modoni, G., Cordio, S., Giuliani, F., Biglietto, M., Montesarchio, V., Barone, C., Tonini, G., Cinieri, S., Febbraro, A., Rizzi, D., De Vita, F., Orditura, M., Colucci, G., Maiello, E., Ciardiello, F., Iaffaioli, Vincenzo, Nasti, Guglielmo, Nappi, Anna, Botti, Gerardo, Tatangelo, F., Chicchinelli, Nicoletta, Montrone, Mirko, Sebastio, Annamaria, Guarino, Tiziana, Simone, Gianni, Graziano, Paolo, Chiarazzo, Cinzia, Maggio, GabrieleDi, Longhitano, Laura, Manusia, Mario, Cartenì, Giacomo, Nappi, Oscar, Micheli, Pietro, Leo, Luigi, Rossi, Sabrina, Cassano, Alessandra, Tommaselli, Eugenio, Giordano, Guido, Sponziello, Francesco, Marino, Antonella, Rinaldi, Antonio, Romito, Sante, Muda, Andrea Onetti, Lorusso, Vito, Leo, Silvana, Barni, Sandro, Grimaldi, Giuseppe, and Aieta, Michele

Published
2016
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37. Impact of endobiliary radiofrequency ablation on survival of patients with unresectable cholangiocarcinoma: a narrative review

Author

Di Girolamo, Elena, primary, Belli, Andrea, additional, Ottaiano, Alessandro, additional, Granata, Vincenza, additional, Borzillo, Valentina, additional, Tarotto, Luca, additional, Tatangelo, Fabiana, additional, Palaia, Raffaele, additional, Civiletti, Corrado, additional, Piccirillo, Mauro, additional, D’Angelo, Valentina, additional, Fiore, Francesco, additional, Marone, Pietro, additional, Nasti, Guglielmo, additional, Izzo, Francesco, additional, and de Bellis, Mario, additional

Published
2023
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38. Supplementary Data from Prospective Evaluation of Cetuximab-Mediated Antibody-Dependent Cell Cytotoxicity in Metastatic Colorectal Cancer Patients Predicts Treatment Efficacy

Author

Trotta, Anna Maria, primary, Ottaiano, Alessandro, primary, Romano, Carmela, primary, Nasti, Guglielmo, primary, Nappi, Anna, primary, De Divitiis, Chiara, primary, Napolitano, Maria, primary, Zanotta, Serena, primary, Casaretti, Rossana, primary, D'Alterio, Crescenzo, primary, Avallone, Antonio, primary, Califano, Daniela, primary, Iaffaioli, Rosario Vincenzo, primary, and Scala, Stefania, primary

Published
2023
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39. Data from Prospective Evaluation of Cetuximab-Mediated Antibody-Dependent Cell Cytotoxicity in Metastatic Colorectal Cancer Patients Predicts Treatment Efficacy

Author

Trotta, Anna Maria, primary, Ottaiano, Alessandro, primary, Romano, Carmela, primary, Nasti, Guglielmo, primary, Nappi, Anna, primary, De Divitiis, Chiara, primary, Napolitano, Maria, primary, Zanotta, Serena, primary, Casaretti, Rossana, primary, D'Alterio, Crescenzo, primary, Avallone, Antonio, primary, Califano, Daniela, primary, Iaffaioli, Rosario Vincenzo, primary, and Scala, Stefania, primary

Published
2023
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40. Supplementary Figure 2 from Prospective Evaluation of Cetuximab-Mediated Antibody-Dependent Cell Cytotoxicity in Metastatic Colorectal Cancer Patients Predicts Treatment Efficacy

Author

Trotta, Anna Maria, primary, Ottaiano, Alessandro, primary, Romano, Carmela, primary, Nasti, Guglielmo, primary, Nappi, Anna, primary, De Divitiis, Chiara, primary, Napolitano, Maria, primary, Zanotta, Serena, primary, Casaretti, Rossana, primary, D'Alterio, Crescenzo, primary, Avallone, Antonio, primary, Califano, Daniela, primary, Iaffaioli, Rosario Vincenzo, primary, and Scala, Stefania, primary

Published
2023
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41. Supplementary Figure 1 from Prospective Evaluation of Cetuximab-Mediated Antibody-Dependent Cell Cytotoxicity in Metastatic Colorectal Cancer Patients Predicts Treatment Efficacy

Author

Trotta, Anna Maria, primary, Ottaiano, Alessandro, primary, Romano, Carmela, primary, Nasti, Guglielmo, primary, Nappi, Anna, primary, De Divitiis, Chiara, primary, Napolitano, Maria, primary, Zanotta, Serena, primary, Casaretti, Rossana, primary, D'Alterio, Crescenzo, primary, Avallone, Antonio, primary, Califano, Daniela, primary, Iaffaioli, Rosario Vincenzo, primary, and Scala, Stefania, primary

Published
2023
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43. Correction To: High tumor mutational burden assessed through next‑generation sequencing predicts favorable survival in microsatellite stable metastatic colon cancer patients.

Author

Di Mauro, Annabella, Santorsola, Mariachiara, Savarese, Giovanni, Sirica, Roberto, Ianniello, Monica, Maria Cossu, Alessia, Ceccarelli, Anna, Sabbatino, Francesco, Bocchetti, Marco, Chiara Carratu, Anna, Pentimalli, Francesca, Ferrara, Gerardo, Nasti, Guglielmo, Caraglia, Michele, and Ottaiano, Alessandro

Subjects
COLON cancer, METASTASIS, NUMBER theory, MICROSATELLITE repeats, CANCER patients
Published
2025
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44. Oligo-Metastatic Cancers: Putative Biomarkers, Emerging Challenges and New Perspectives

Author

Ottaiano, Alessandro, primary, Santorsola, Mariachiara, additional, Circelli, Luisa, additional, Trotta, Anna Maria, additional, Izzo, Francesco, additional, Perri, Francesco, additional, Cascella, Marco, additional, Sabbatino, Francesco, additional, Granata, Vincenza, additional, Correra, Marco, additional, Tarotto, Luca, additional, Stilo, Salvatore, additional, Fiore, Francesco, additional, Martucci, Nicola, additional, Rocca, Antonello La, additional, Picone, Carmine, additional, Muto, Paolo, additional, Borzillo, Valentina, additional, Belli, Andrea, additional, Patrone, Renato, additional, Mercadante, Edoardo, additional, Tatangelo, Fabiana, additional, Ferrara, Gerardo, additional, Di Mauro, Annabella, additional, Scognamiglio, Giosué, additional, Berretta, Massimiliano, additional, Capuozzo, Maurizio, additional, Lombardi, Angela, additional, Galon, Jérôme, additional, Gualillo, Oreste, additional, Pace, Ugo, additional, Delrio, Paolo, additional, Savarese, Giovanni, additional, Scala, Stefania, additional, Nasti, Guglielmo, additional, and Caraglia, Michele, additional

Published
2023
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45. Plasma metabolomics, lipidomics and cytokinomics profiling predict disease recurrence in metastatic colorectal cancer patients undergoing liver resection

Author

Costantini, Susan, primary, Di Gennaro, Elena, additional, Capone, Francesca, additional, De Stefano, Alfonso, additional, Nasti, Guglielmo, additional, Vitagliano, Carlo, additional, Setola, Sergio Venanzio, additional, Tatangelo, Fabiana, additional, Delrio, Paolo, additional, Izzo, Francesco, additional, Avallone, Antonio, additional, and Budillon, Alfredo, additional

Published
2023
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47. Updated survival outcomes with ivosidenib in patients with previously treated IDH1-mutated intrahepatic-cholangiocarcinoma: an Italian real-world experience

Author

Rimini, Margherita, primary, Burgio, Valentina, additional, Antonuzzo, Lorenzo, additional, Rimassa, Lorenza, additional, Oneda, Ester, additional, Soldà, Caterina, additional, Cito, Pasqua, additional, Nasti, Guglielmo, additional, Lavacchi, Daniele, additional, Zanuso, Valentina, additional, Rizzato, Mario Domenico, additional, Zaniboni, Alberto, additional, Ottaiano, Alessandro, additional, Persano, Mara, additional, Cornara, Noemi, additional, Scartozzi, Mario, additional, Cascinu, Stefano, additional, and Casadei-Gardini, Andrea, additional

Published
2023
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48. Influence of K-ras status and anti-tumour treatments on complications due to colorectal self-expandable metallic stents: A retrospective multicentre study

Author

Altimari, Annalisa, Cariani, Giulio, Caruso, Angelo, Conigliaro, Rita, Crosta, Cristiano, Delrio, Paolo, Di Marco, Maria Cristina, Fabbri, Carlo, Fiorentino, Michelangelo, Ghersi, Stefania, Gruppioni, Elisa, Hassan, Cesare, Laterza, Liboria, Nasti, Guglielmo, Pinto, Carmine, Rojas, Fabiola, Scaioli, Eleonora, Fuccio, Lorenzo, Correale, Loredana, Arezzo, Alberto, Repici, Alessandro, Manes, Gianpiero, Trovato, Cristina, Mangiavillano, Benedetto, Manno, Mauro, Cortelezzi, Claudio Camillo, Dinelli, Marco, Cennamo, Vincenzo, and de Bellis, Mario

Published
2014
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49. Characterization of KRAS Mutational Regression in Oligometastatic Patients

Author

Ottaiano, Alessandro, de Vera d'Aragona, Roberta Penta, Trotta, Anna Maria, Santorsola, Mariachiara, Napolitano, Maria, Scognamiglio, Giosuè, Tatangelo, Fabiana, Grieco, Paolo, Zappavigna, Silvia, Granata, Vincenza, Perri, Francesco, Luce, Amalia, Savarese, Giovanni, Ianniello, Monica, Casillo, Marika, Petrillo, Nadia, Belli, Andrea, Izzo, Francesco, Nasti, Guglielmo, Caraglia, Michele, Scala, Stefania, Ottaiano, Alessandro, de Vera d'Aragona, Roberta Penta, Trotta, Anna Maria, Santorsola, Mariachiara, Napolitano, Maria, Scognamiglio, Giosuè, Tatangelo, Fabiana, Grieco, Paolo, Zappavigna, Silvia, Granata, Vincenza, Perri, Francesco, Luce, Amalia, Savarese, Giovanni, Ianniello, Monica, Casillo, Marika, Petrillo, Nadia, Belli, Andrea, Izzo, Francesco, Nasti, Guglielmo, Caraglia, Michele, and Scala, Stefania

Subjects
HLA, Proto-Oncogene Proteins p21(ras), Immunology, Colonic Neoplasms, Mutation, KRAS, cytotoxicity, Immunology and Allergy, Humans, colorectal cancer, oligo-metastatic disease, Colorectal Neoplasms, Prognosis
Abstract

BackgroundWe previously reported rare regressive genetic trajectories of KRAS pathogenic mutations as a specific hallmark of the genuine oligometastatic status in colorectal cancer (CRC).MethodsSurvival and prognostic impact of disease extent in 140 metastatic CRC patients were evaluated through the Kaplan–Meyer curves and the Log-Rank test. KRAS mutations were assessed through the Illumina NovaSeq 6000 platform and TruSight™ Oncology 500 kit. HLA typing was carried out by PCR with sequence-specific oligonucleotides. Lymphocyte densities in tumors were expressed as cells per square millimeter. NKs isolated and CD8+ from NK-depleted PBMCs were characterized through flow cytometry. CD107a externalization was evaluated as NKs/CD8 cytotoxicity toward human colon cancer cells HT29, SW620, HCT116, and LS174T carrying different KRAS mutations.ResultsThe oligometastatic status was a strong and independent variable for survival (HR: 0.08 vs. polymetastatic disease; 95% CI: 0.02–0.26; p KRAS was observed in 3 patients: patient (PAT)2, PAT5, and PAT8. PAT2 and PAT5 presented the highest levels of GrzB+ lymphocytes in the tumor cores of the metastases (120 ± 11.2 and 132 ± 12.2 cells/mm2, respectively). Six out of 9 patients (67%), including PAT2 and PAT5, expressed HLA-C7. Twopatients (PAT2 and PAT5) presented high CD3+/CD8+-dependent cytotoxicity against HLA-C7+ SW620 cells (p.G12V-mutated cells), which was consistent with their observed mutational regression (p.G12V/p.G13D in primary→p.G13D in metastatic tumor).ConclusionsWe provide evidence that CD3+/CD8+ lymphocytes from oligometastatic CRC patients display differential cytotoxicity against human colon cancer cells carrying KRAS mutations. This could provide an interesting basis for monitoring oligometastatic disease and developing future adoptive immunotherapies.

Published
2022

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