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Anxiety and depression are pathologies that affect human beings in many aspects of life, including social life, productivity and health. Cannabidiol (CBD) is a constituent non-psychotomimetic of Cannabis sativa with great psychiatric potential, including uses as an antidepressant-like and anxiolytic-like compound. The aim of this study is to review studies of animal models using CBD as an anxiolytic-like and antidepressant-like compound. Studies involving animal models, performing a variety of experiments on the above-mentioned disorders, such as the forced swimming test (FST), elevated plus maze (EPM) and Vogel conflict test (VCT), suggest that CBD exhibited an anti-anxiety and antidepressant effects in animal models discussed. Experiments with CBD demonstrated non-activation of neuroreceptors CB1 and CB2. Most of the studies demonstrated a good interaction between CBD and the 5-HT1A neuro-receptor.

Behcet's syndrome (BD) is a controversial, chronic, and episodic condition that is autoimmune in origin and causes systemic vasculitis in the arteries and genital veins. BD is consistently associated with depression, with an incidence of 86% upon the first appearance of symptoms and disorders of the disease. However, few studies have looked at depression and other psychiatric disorders, such as anxiety, in the context of comorbidity with BD. The aim of this review is to identify articles that focus on the relation between BD and depression as a comorbidity. The studies found revealed a consistently high incidence of depression in the BD population, even when compared with other chronic pathologies including Rheumatoid Arthritis and Psoriasis, although there was a limitation in the use of scales and other tools for assessment and control of comorbid symptoms, moreover there are no studies linking the drugs used in the BD treatment of each patient and the symptoms present in each case. This review clearly shows the lack of research in which depression scores are analyzed in relation to the medications used by individual patients. Additionally, the use of additional scales is necessary to increase the knowledge about the nature and consequences of depression as comorbidity of BD.

Health professionals have used virtual reality as an aid for several types of treatment. Given that virtual reality systems are expensive and not always available, a more accessible type of virtual reality technology is video games. The Nintendo Wii(TM) (NW) is a video game system that uses virtual reality technology, as defined by Deutsch, Borbely, Filler, Huhn, and Guarrera-Bowlby (2008), which may be used for health promotion. The Nintendo Wii(TM) also provides an opportunity for social interaction; thus, it is a promising tool with great potential for the treatment of specific disorders. The aim of this article is to evaluate the ways in which the Nintendo Wii has been used to treat specific disorders or to promote cognitive or physical improvements through a review of the literature. The results have shown that the NW is a potentially useful tool in some therapeutic treatments that can be used with people of diverse social statuses and tastes. Despite the positive initial results, further studies are required to provide a better evaluation of video game usage in therapeutic programs.

Objective: This paper aims to investigate the prevalence of anxiety, depression and suicidal ideation in patients with rheumatoid arthritis taking different drugs to control the disease. Methods: The study included 105 patients with rheumatoid arthritis who were treated with methotrexate, leflunomide, hydroxychloroquine and biological drugs. All patients were assessed using the Mini International Neuropsychiatric Interview, the Beck Scale for Suicide Ideation and the Hospital Anxiety and Depression Scale. Results: Difference was statistically significant (p

INTRODUÇÃO: Atualmente há um aumento crescente no número de diagnósticos de artrite reumatoide, seja graças à evolução dos métodos diagnósticos ou a intensas pesquisas realizadas na área de reumatologia, porém há uma lacuna quanto a instrumentos de medidas para acompanhamento no campo físico e psíquico da evolução dessa doença, que pode causar limitações físicas graves com o seu avanço, além do comprometimento de diversos aspectos da qualidade de vida. OBJETIVO: Este estudo tem como objetivo desenvolver a versão em português brasileiro do Michigan Hand Outcomes Questionnaire, um instrumento de avaliação e monitoramento do estado de saúde em pacientes com transtornos e doenças que incapacitam as atividades cotidianas realizadas pelas suas mãos. MÉTODOS: Foram realizadas duas traduções e retrotraduções por avaliadores independentes e cegos quanto ao instrumento original, seguidas de composição de uma versão sintética, testada experimentalmente em um grupo de sujeitos da população geral e também pacientes com diagnóstico de artrite. RESULTADOS: São apresentadas todas as fases do processo. A participação de tradutores especialistas em saúde mental, reumatologia e ortopedia favoreceu a adequação dos termos utilizados ao construto mensurado. A aplicação experimental evidenciou a correta compreensão de todos os itens, quanto ao seu significado, por todos os respondentes. CONCLUSÃO: Elaborada a versão em português brasileiro da Michigan Hand Outcomes Questionnaire.

INTRODUÇÃO: Com a crescente procura pelo acompanhamento psicológico de pacientes com doenças crônicas e indicações clínicas para o monitoramento de suas capacidades físicas e psíquicas, existe a necessidade de instrumentos que possibilitem essa avaliação. A artrite reumatoide é uma doença que vem sendo amplamente estudada para que novas drogas e tratamentos sejam desenvolvidos, porém instrumentos psicométricos desenvolvidos para essa população específica ainda são raros. OBJETIVO: Descrever a adaptação transcultural, para o português brasileiro, da Recent-Onset Arthritis Disability (ROAD) index. MÉTODOS: O processo envolveu duas traduções e retrotraduções realizadas por quatro tradutores independentes, a avaliação das versões fornecidas, seguida da elaboração de uma versão sintética por especialistas no assunto. O processo foi finalizado com a aplicação experimental do instrumento. RESULTADOS: Todas as etapas do processo são descritas. Não foram percebidas dificuldades de compreensão na autoaplicação da escala, que foi realizada por grupos de diferentes níveis de instrução, compreendendo desde ensino fundamental até nível universitário completo. CONCLUSÃO: Ao final do estudo, é apresentada a versão final da ROAD em português brasileiro. O instrumento adaptado foi considerado adequado e correspondente ao instrumento original. INTRODUCTION: The increasing search for the psychological treatment of patients with chronic diseases and with clinical indications for the control of physical and psychological capacities has revealed a need for instruments aimed at assessing these patients. Rheumatoid arthritis is a condition that has been widely studied with a focus on the development of new drugs and treatment approaches. However, psychometric instruments developed for this specific population are still rare. OBJECTIVE: To describe the translation and cross-cultural adaptation into Brazilian Portuguese of the Recent-Onset Arthritis Disability (ROAD) index. METHODS: The process involved two translations and back-translations performed by four independent translators, the assessment of all versions obtained, followed by the development of a synthetic version by specialists in the field. The process was completed with an experimental application of the instrument. RESULTS: All stages of the translation/adaptation process are described. No comprehension difficulties were reported by the participants, who had different education levels, ranging from elementary school to university level. CONCLUSION: At the end of the study, the final version of the ROAD index in Brazilian Portuguese is presented. The adapted instrument was considered adequate and equivalent in meaning to the original instrument.

Suicide is considered a deliberate act initiated and concluded by a person with full knowledge or expectation of a fatal result, and one of the main symptoms of depression. An individual's conscious and excessive ingestion of a damaging substance is also considered to be an attempted suicide. Despite limited knowledge of caffeine abuse, deaths from overdose of caffeine have been reported in the literature. Thus, this study aims to review the existing literature on caffeine consumption and suicide attempts and deaths, investigating the relation between caffeine consumption and suicide attempts and deaths. We found 24 studies that discuss the relationship between caffeine and suicide. The findings revealed that, despite being an addictive substance and potentially fatal in higher doses, caffeine was still a rare factor in a number of studies concerning its relation with suicide attempts and death. The majority of the research found in this study was of the case study type. Furthermore, the majority of studies focus on the assistance offered to the victim and the procedures undertaken to control the bodily damage created. The existing studies indicate the substance may act as either a direct or an indirect agent in suicide. Therefore, a better understanding of how caffeine may be linked to suicide is crucial for its prevention.

Despite grief being a universal experience and the increased scientific attention paid to grief and bereavement in recent years, studies that seek to better understand the role of the neurological aspects of grief are still scarce. We found 5 studies that discussed the relationship between the neurological aspects of grief due to the death of a loved one. All studies showed an activation of common areas, i.e., the anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), prefrontal cortex (PFC), insula and amygdala. These findings could indicate that there is a group of areas working together and responding to generate the symptomatology of grief. Because grief is a universal experience, it is essential that the necessary and effective support can be provided to those who experience the loss of someone considered important in their lives, and this requires understanding grief’s manifestation, its differential diagnosis in reference to other clinical conditions, mainly psychiatric ones, and adequate forms of intervention and treatment when necessary. Proper understanding and support can help prevent the emergence of more serious health problems.

The increasing search for the psychological treatment of patients with chronic diseases and with clinical indications for the control of physical and psychological capacities has revealed a need for instruments aimed at assessing these patients. Rheumatoid arthritis is a condition that has been widely studied with a focus on the development of new drugs and treatment approaches. However, psychometric instruments developed for this specific population are still rare.To describe the translation and cross-cultural adaptation into Brazilian Portuguese of the Recent-Onset Arthritis Disability (ROAD) index.The process involved two translations and back-translations performed by four independent translators, the assessment of all versions obtained, followed by the development of a synthetic version by specialists in the field. The process was completed with an experimental application of the instrument.All stages of the translation/adaptation process are described. No comprehension difficulties were reported by the participants, who had different education levels, ranging from elementary school to university level.At the end of the study, the final version of the ROAD index in Brazilian Portuguese is presented. The adapted instrument was considered adequate and equivalent in meaning to the original instrument.