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Your search keyword '"Natalya Belogortseva"' showing total 2 results
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2 results on '"Natalya Belogortseva"'

1. Intestinal tissues induce an SNP mutation in Pseudomonas aeruginosa that enhances its virulence: possible role in anastomotic leak.

Author

Andrea D Olivas, Benjamin D Shogan, Vesta Valuckaite, Alexander Zaborin, Natalya Belogortseva, Mark Musch, Folker Meyer, William L Trimble, Gary An, Jack Gilbert, Olga Zaborina, and John C Alverdy

Subjects
Medicine, Science
Abstract

The most feared complication following intestinal resection is anastomotic leakage. In high risk areas (esophagus/rectum) where neoadjuvant chemoradiation is used, the incidence of anastomotic leaks remains unacceptably high (≈ 10%) even when performed by specialist surgeons in high volume centers. The aims of this study were to test the hypothesis that anastomotic leakage develops when pathogens colonizing anastomotic sites become in vivo transformed to express a tissue destroying phenotype. We developed a novel model of anastomotic leak in which rats were exposed to pre-operative radiation as in cancer surgery, underwent distal colon resection and then were intestinally inoculated with Pseudomonas aeruginosa, a common colonizer of the radiated intestine. Results demonstrated that intestinal tissues exposed to preoperative radiation developed a significant incidence of anastomotic leak (>60%; p

Published
2012
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2. Intestinal tissues induce an SNP mutation in Pseudomonas aeruginosa that enhances its virulence: possible role in anastomotic leak

Author

Folker Meyer, Benjamin D. Shogan, John C. Alverdy, Alexander Zaborin, Gary An, Natalya Belogortseva, Vesta Valuckaite, Andrea D Olivas, Jack A. Gilbert, Mark W. Musch, William L. Trimble, and Olga Zaborina

Subjects
Male, Pathology, lcsh:Medicine, Anastomotic Leak, Apoptosis, medicine.disease_cause, Polyethylene Glycols, Pathogenesis, Cecum, chemistry.chemical_compound, Gastrointestinal Infections, lcsh:Science, Multidisciplinary, Radiation, Anastomosis, Surgical, Microbial Mutation, Animal Models, Phenotype, Bacterial Pathogens, Intestines, Host-Pathogen Interaction, medicine.anatomical_structure, Medical Microbiology, Pseudomonas aeruginosa, Medicine, Radiology, Research Article, medicine.medical_specialty, Colon, Molecular Sequence Data, Gastroenterology and Hepatology, Biology, Protective Agents, Polymorphism, Single Nucleotide, Microbiology, Phosphates, Tight Junctions, Pyocyanin, Model Organisms, In vivo, Gastrointestinal Surgery, medicine, Animals, Rats, Wistar, Caenorhabditis elegans, Wound Healing, Base Sequence, lcsh:R, Rats, Cytolysis, chemistry, Mutation, Microbial Evolution, Zonula Occludens-1 Protein, lcsh:Q, Surgery, Wound healing
Abstract

The most feared complication following intestinal resection is anastomotic leakage. In high risk areas (esophagus/rectum) where neoadjuvant chemoradiation is used, the incidence of anastomotic leaks remains unacceptably high (≈ 10%) even when performed by specialist surgeons in high volume centers. The aims of this study were to test the hypothesis that anastomotic leakage develops when pathogens colonizing anastomotic sites become in vivo transformed to express a tissue destroying phenotype. We developed a novel model of anastomotic leak in which rats were exposed to pre-operative radiation as in cancer surgery, underwent distal colon resection and then were intestinally inoculated with Pseudomonas aeruginosa, a common colonizer of the radiated intestine. Results demonstrated that intestinal tissues exposed to preoperative radiation developed a significant incidence of anastomotic leak (>60%; p

Published
2012

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