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7 results on '"Natarajan, Seanu Meena"'

1. TSG-6+ cancer-associated fibroblasts modulate myeloid cell responses and impair anti-tumor response to immune checkpoint therapy in pancreatic cancer

Author

Anandhan, Swetha, Herbrich, Shelley, Goswami, Sangeeta, Guan, Baoxiang, Chen, Yulong, Macaluso, Marc Daniel, Jindal, Sonali, Natarajan, Seanu Meena, Andrewes, Samuel W., Xiong, Liangwen, Nagarajan, Ashwat, Basu, Sreyashi, Tang, Derek Ng, Liu, Jielin, Min, Jimin, Maitra, Anirban, and Sharma, Padmanee

Published
2024
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2. Myeloid-specific KDM6B inhibition sensitizes glioblastoma to PD1 blockade

Author

Goswami, Sangeeta, primary, Raychaudhuri, Deblina, additional, Singh, Pratishtha, additional, Natarajan, Seanu Meena, additional, Chen, Yulong, additional, Poon, Candice, additional, Hennessey, Mercedes, additional, Tannir, Aminah J., additional, Zhang, Jan, additional, Anandhan, Swetha, additional, Kerrigan, Brittany Parker, additional, Macaluso, Marc D., additional, He, Zhong, additional, Jindal, Sonali, additional, Lang, Frederick F., additional, Basu, Sreyashi, additional, and Sharma, Padmanee, additional

Published
2023
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3. Histone lactylation drives CD8+T cell metabolism and function

Author

Raychaudhuri, Deblina, Singh, Pratishtha, Chakraborty, Bidisha, Hennessey, Mercedes, Tannir, Aminah J., Byregowda, Shrinidhi, Natarajan, Seanu Meena, Trujillo-Ocampo, Abel, Im, Jin Seon, and Goswami, Sangeeta

Abstract

The activation and functional differentiation of CD8+T cells are linked to metabolic pathways that result in the production of lactate. Lactylation is a lactate-derived histone post-translational modification; however, the relevance of histone lactylation in the context of CD8+T cell activation and function is not known. Here, we show the enrichment of H3K18 lactylation (H3K18la) and H3K9 lactylation (H3K9la) in human and mouse CD8+T cells, which act as transcription initiators of key genes regulating CD8+T cell function. Further, we note distinct patterns of H3K18la and H3K9la in CD8+T cell subsets linked to their specific metabolic profiles. Additionally, we find that modulation of H3K18la and H3K9la by targeting metabolic and epigenetic pathways influence CD8+T cell effector function, including antitumor immunity, in preclinical models. Overall, our study uncovers the potential roles of H3K18la and H3K9la in CD8+T cells.

Published
2024
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4. Myeloid-specific KDM6B inhibition sensitizes Glioblastoma to PD1 blockade

Author

Goswami, Sangeeta, primary, Raychaudhuri, Deblina, additional, Singh, Pratishtha, additional, Natarajan, Seanu Meena, additional, Chen, Yulong, additional, Poon, Candice, additional, Hennessey, Mercedes, additional, Zhang, Jan, additional, Anandhan, Swetha, additional, Kerrigan, Brittany Parker, additional, Macaluso, Marc D., additional, He, Zhong, additional, Jindal, Sonali, additional, Lang, Frederick F., additional, Basu, Sreyashi, additional, and Sharma, Padmanee, additional

Published
2022
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5. ARID1A mutation plus CXCL13 expression act as combinatorial biomarkers to predict responses to immune checkpoint therapy in mUCC

Author

Goswami, Sangeeta, primary, Chen, Yulong, additional, Anandhan, Swetha, additional, Szabo, Peter M., additional, Basu, Sreyashi, additional, Blando, Jorge M., additional, Liu, Wenbin, additional, Zhang, Jan, additional, Natarajan, Seanu Meena, additional, Xiong, Liangwen, additional, Guan, Baoxiang, additional, Yadav, Shalini Singh, additional, Saci, Abdel, additional, Allison, James P., additional, Galsky, Matthew D., additional, and Sharma, Padmanee, additional

Published
2020
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6. ARID1Amutation plus CXCL13 expression act as combinatorial biomarkers to predict responses to immune checkpoint therapy in mUCC

Author

Goswami, Sangeeta, Chen, Yulong, Anandhan, Swetha, Szabo, Peter M., Basu, Sreyashi, Blando, Jorge M., Liu, Wenbin, Zhang, Jan, Natarajan, Seanu Meena, Xiong, Liangwen, Guan, Baoxiang, Yadav, Shalini Singh, Saci, Abdel, Allison, James P., Galsky, Matthew D., and Sharma, Padmanee

Abstract

A combination of ARID1Amutation and CXCL13 expression in baseline tumor tissues improves predictive capability for patients with mUCC receiving ICT.

Published
2020
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7. Histone lactylation drives CD8 + T cell metabolism and function.

Author

Raychaudhuri D, Singh P, Chakraborty B, Hennessey M, Tannir AJ, Byregowda S, Natarajan SM, Trujillo-Ocampo A, Im JS, and Goswami S

Subjects
Animals, Humans, Mice, Mice, Inbred C57BL, Epigenesis, Genetic, Cell Differentiation, CD8-Positive T-Lymphocytes immunology, CD8-Positive T-Lymphocytes metabolism, Histones metabolism, Protein Processing, Post-Translational, Lymphocyte Activation immunology
Abstract

The activation and functional differentiation of CD8 + T cells are linked to metabolic pathways that result in the production of lactate. Lactylation is a lactate-derived histone post-translational modification; however, the relevance of histone lactylation in the context of CD8 + T cell activation and function is not known. Here, we show the enrichment of H3K18 lactylation (H3K18la) and H3K9 lactylation (H3K9la) in human and mouse CD8 + T cells, which act as transcription initiators of key genes regulating CD8 + T cell function. Further, we note distinct patterns of H3K18la and H3K9la in CD8 + T cell subsets linked to their specific metabolic profiles. Additionally, we find that modulation of H3K18la and H3K9la by targeting metabolic and epigenetic pathways influence CD8 + T cell effector function, including antitumor immunity, in preclinical models. Overall, our study uncovers the potential roles of H3K18la and H3K9la in CD8 + T cells., (© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.)

Published
2024
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