1. Genome-wide transcriptional profiling in human squamous cell carcinoma of the skin identifies unique tumor-associated signatures
- Author
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Darja Kanduc, Zhaoying Xiang, Animesh A. Sinha, Lucy Lomas, Nathan Skelley, Robert J. Markelewicz, Vinnie P. Kathpalia, Michael Time, Erich N. Mussak, Phillip H. Lam, and Selwyn Chow
- Subjects
Male ,DNA, Complementary ,Skin Neoplasms ,Transcription, Genetic ,Dermatology ,Biology ,Bioinformatics ,Genome ,Pathogenesis ,Humans ,Genetic Predisposition to Disease ,Aged ,Aged, 80 and over ,Genome, Human ,Reverse Transcriptase Polymerase Chain Reaction ,Gene Expression Profiling ,DNA replication ,General Medicine ,Phenotype ,PTPN11 ,Gene expression profiling ,Gene Expression Regulation, Neoplastic ,stomatognathic diseases ,Cell Transformation, Neoplastic ,Case-Control Studies ,Cancer research ,Carcinoma, Squamous Cell ,RNA ,Female ,sense organs ,Signal transduction ,DNA microarray - Abstract
The elucidation of specific genetic changes associated with human cancer pathogenesis has focused efforts to relate such changes to the neoplastic phenotype. To further our understanding of the genetic basis of human squamous cell carcinoma (SCC) of the skin, this study used a genome-wide (12 627 sequences) approach to determine transcriptional signatures in lesional and nonlesional sites from five SCC patients. Several novel genes involving the p53 pathway, anti-apoptotic pathways, signal transduction, structural loss and DNA replication, including BCL2A1, MUC4, PTPN11 (SHP2) and FGF9, are upregulated in SCC and could warrant further study regarding their role in disease pathogenesis. SCC pathology is likely combinatorial in nature involving the compounded changes from several cellular processes.
- Published
- 2006