1. Obesity and the microvasculature: A systematic review and meta-analysis
- Author
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Barbara E.K. Klein, Aljoscha Steffen Neubauer, Paul Mitchell, Sébastien Czernichow, Mohammad Kamran Ikram, Ronald Klein, Sophia Zoungas, Bamini Gopinath, Seang-Mei Saw, Adrien Boillot, Jie Jin Wang, Tien Yin Wong, Serge Hercberg, E. Shyong Tai, Caroline C W Klaver, Laima Brazionis, Université Paris Diderot - Paris 7 (UPD7), Hôpital Ambroise Paré [AP-HP], George Institute for Global Health, The University of Sydney, Westmead Institute for Medical Research, Partenaires INRAE, University of Wisconsin-Madison, Saw Swee Hock School of Public Health, National University of Singapore (NUS), Erasmus University Rotterdam, Singapore Eye Research Institute, Department of Medicine, University of Melbourne-Royal Melbourne Hospital, Ludwig Maximilians University of Munich, Unité de Recherche en Epidémiologie Nutritionnelle (UREN), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), PRES Sorbonne Paris Cité, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), National Health and Medical Research Council [124317, 396414, 209057], National Heart Foundation, Centre for Clinical Research Excellence in Clinical Science in Diabetes, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Sorbonne Paris Cité (USPC)-Université Paris 13 (UP13)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut National de la Recherche Agronomique (INRA), ProdInra, Migration, Ludwig-Maximilians University [Munich] (LMU), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Ophthalmology, and Obstetrics & Gynecology
- Subjects
Pathology ,Epidemiology ,[SDV]Life Sciences [q-bio] ,030204 cardiovascular system & hematology ,Overweight ,Cardiovascular ,Body Mass Index ,0302 clinical medicine ,Risk Factors ,maladie cardiovasculaire ,Child ,Prospective cohort study ,2. Zero hunger ,Multidisciplinary ,indice de masse corporelle ,Diabetic retinopathy ,Middle Aged ,3. Good health ,[SDV] Life Sciences [q-bio] ,obésité ,Meta-analysis ,030220 oncology & carcinogenesis ,Cardiology ,Retinal Disorders ,Medicine ,medicine.symptom ,Research Article ,Adult ,medicine.medical_specialty ,Systematic Reviews ,Adolescent ,Clinical Research Design ,Science ,Childhood obesity ,03 medical and health sciences ,SDG 3 - Good Health and Well-being ,Vascular Biology ,Internal medicine ,medicine ,Humans ,Obesity ,Cardiovascular Disease Epidemiology ,Nutrition ,Aged ,business.industry ,Retinal Vessels ,surpoids ,medicine.disease ,Ophthalmology ,Intima-media thickness ,Microvessels ,030221 ophthalmology & optometry ,Meta-Analyses ,Metabolic syndrome ,business ,Body mass index ,030217 neurology & neurosurgery - Abstract
International audience; Background: Overweight and obesity are thought to significantly influence a person's risk of cardiovascular disease, possibly via its effect on the microvasculature. Retinal vascular caliber is a surrogate marker of microvascular disease and a predictor of cardiovascular events. The aim of this systematic review and meta-analysis was to determine the association between body mass index (BMI) and retinal vascular caliber. Methods and Findings: Relevant studies were identified by searches of the MEDLINE and EMBASE databases from 1966 to August 2011. Standardized forms were used for data extraction. Among over 44,000 individuals, obese subjects had narrower arteriolar and wider venular calibers when compared with normal weight subjects, independent of conventional cardiovascular risk factors. In adults, a 1 kg/m(2) increase in BMI was associated with a difference of 0.07 mm [95% CI: -0.08; -0.06] in arteriolar caliber and 0.22 mu m [95% CI: 0.21; 0.23] in venular caliber. Similar results were found for children. Conclusions: Higher BMI is associated with narrower retinal arteriolar and wider venular calibers. Further prospective studies are needed to examine whether a causative relationship between BMI and retinal microcirculation exists.
- Published
- 2013
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