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19 results on '"Nativi, Jose N"'

3. Locomotor Muscle Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction

Author

Francisco, Michael A., primary, Lee, Joshua F., additional, Barrett-O’Keefe, Zachary, additional, Groot, H. Jonathan, additional, Ratchford, Stephen M., additional, Bunsawat, Kanokwan, additional, Alpenglow, Jeremy K., additional, Ryan, John J., additional, Nativi, Jose N., additional, Richardson, Russell S., additional, and Wray, D. Walter, additional

Published
2021
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10. Morbidity and Mortality in Heart Transplant Candidates Supported With Mechanical Circulatory Support

Author

Wever-Pinzon, Omar, primary, Drakos, Stavros G., additional, Kfoury, Abdallah G., additional, Nativi, Jose N., additional, Gilbert, Edward M., additional, Everitt, Melanie, additional, Alharethi, Rami, additional, Brunisholz, Kim, additional, Bader, Feras M., additional, Li, Dean Y., additional, Selzman, Craig H., additional, and Stehlik, Josef, additional

Published
2013
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14. Changing outcomes in patients bridged to heart transplantation with continuous- versus pulsatile-flow ventricular assist devices: An analysis of the registry of the International Society for Heart and Lung Transplantation

Author

Nativi, Jose N., primary, Drakos, Stavros G., additional, Kucheryavaya, Anna Y., additional, Edwards, Leah B., additional, Selzman, Craig H., additional, Taylor, David O., additional, Hertz, Marshall I., additional, Kfoury, Abdallah G., additional, and Stehlik, Josef, additional

Published
2011
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15. Understanding exercise-induced hyperemia: central and peripheral hemodynamic responses to passive limb movement in heart transplant recipients

Author

Hayman, Melissa A., primary, Nativi, Jose N., additional, Stehlik, Josef, additional, McDaniel, John, additional, Fjeldstad, Anette S., additional, Ives, Stephen J., additional, Walter Wray, D., additional, Bader, Feras, additional, Gilbert, Edward M., additional, and Richardson, Russell S., additional

Published
2010
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17. Effects of the 2006 U.S. thoracic organ allocation change: Analysis of local impact on organ procurement and heart transplantation

Author

Nativi, Jose N., primary, Kfoury, Abdallah G., additional, Myrick, Craig, additional, Peters, Melissa, additional, Renlund, Dale, additional, Gilbert, Edward M., additional, Bader, Feras, additional, Singhal, Arun K., additional, Everitt, Melanie, additional, Fisher, Patrick, additional, Bull, David A., additional, Selzman, Craig, additional, and Stehlik, Josef, additional

Published
2010
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18. A differing role of oxidative stress in the regulation of central and peripheral hemodynamics during exercise in heart failure.

Author

Witman MA, McDaniel J, Fjeldstad AS, Ives SJ, Zhao J, Nativi JN, Stehlik J, Wray DW, and Richardson RS

Subjects
Administration, Oral, Antioxidants administration & dosage, Arterial Pressure, Ascorbic Acid administration & dosage, Ascorbic Acid blood, Biomarkers blood, Blood Flow Velocity, Brachial Artery diagnostic imaging, Brachial Artery physiopathology, Cross-Over Studies, Hand Strength, Heart Failure diagnostic imaging, Heart Failure metabolism, Humans, Male, Malondialdehyde blood, Middle Aged, Muscle Contraction, Regional Blood Flow, Single-Blind Method, Superoxide Dismutase blood, Thioctic Acid administration & dosage, Time Factors, Ultrasonography, Doppler, Utah, Vascular Resistance, Vitamin E administration & dosage, Exercise, Heart Failure physiopathology, Hemodynamics drug effects, Muscle, Skeletal metabolism, Oxidative Stress drug effects
Abstract

This study sought to characterize the role of free radicals in regulating central and peripheral hemodynamics at rest and during exercise in patients with heart failure (HF). We examined cardiovascular responses to dynamic handgrip exercise (4, 8, and 12 kg at 1 Hz) following consumption of either a placebo or acute oral antioxidant cocktail (AOC) consisting of vitamin C, E, and α-lipoic acid in a balanced, crossover design. Central and peripheral hemodynamics, mean arterial pressure, cardiac index, systemic vascular resistance (SVR), brachial artery blood flow, and peripheral (arm) vascular resistance (PVR) were determined in 10 HF patients and 10 age-matched controls. Blood assays evaluated markers of oxidative stress and efficacy of the AOC. When compared with controls, patients with HF exhibited greater oxidative stress, measured by malondialdehyde (+36%), and evidence of endogenous antioxidant compensation, measured by greater superoxide dismutase activity (+83%). The AOC increased plasma ascorbate (+50%) in both the HF patients and controls, but significant systemic hemodynamic effects were only evident in the patients with HF, both at rest and throughout exercise. Specifically, the AOC reduced mean arterial pressure (-5%) and SVR (-12%) and increased cardiac index (+7%) at each workload. In contrast, peripherally, brachial artery blood flow and PVR (arm) were unchanged by the AOC. In conclusion, these data imply that SVR in patients with HF is, at least in part, mediated by oxidative stress. However, this finding does not appear to be the direct result of muscle-specific changes in PVR.

Published
2012
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19. Understanding exercise-induced hyperemia: central and peripheral hemodynamic responses to passive limb movement in heart transplant recipients.

Author

Hayman MA, Nativi JN, Stehlik J, McDaniel J, Fjeldstad AS, Ives SJ, Walter Wray D, Bader F, Gilbert EM, and Richardson RS

Subjects
Blood Volume physiology, Carbon Monoxide metabolism, Cardiac Output physiology, Case-Control Studies, Female, Hemodynamics physiology, Humans, Leg physiology, Male, Middle Aged, Stroke Volume physiology, Exercise physiology, Femoral Artery physiology, Heart Rate physiology, Heart Transplantation physiology, Hyperemia physiopathology, Leg blood supply, Regional Blood Flow physiology
Abstract

To better characterize the contribution of both central and peripheral mechanisms to passive limb movement-induced hyperemia, we studied nine recent (<2 yr) heart transplant (HTx) recipients (56 ± 4 yr) and nine healthy controls (58 ± 5 yr). Measurements of heart rate (HR), stroke volume (SV), cardiac output (CO), and femoral artery blood flow were recorded during passive knee extension. Peripheral vascular function was assessed using brachial artery flow-mediated dilation (FMD). During passive limb movement, the HTx recipients lacked an HR response (0 ± 0 beats/min, Δ0%) but displayed a significant increase in CO (0.4 ± 0.1 l/min, Δ5%) although attenuated compared with controls (1.0 ± 0.2 l/min, Δ18%). Therefore, the rise in CO in the HTx recipients was solely dependent on increased SV (5 ± 1 ml, Δ5%) in contrast with the controls who displayed significant increases in both HR (6 ± 2 beats/min, Δ11%) and SV (5 ± 2 ml, Δ7%). The transient increase in femoral blood volume entering the leg during the first 40 s of passive movement was attenuated in the HTx recipients (24 ± 8 ml) compared with controls (93 ± 7 ml), whereas peripheral vascular function (FMD) appeared similar between HTx recipients (8 ± 2%) and controls (6 ± 1%). These data reveal that the absence of an HR increase in HTx recipients significantly impacts the peripheral vascular response to passive movement in this population and supports the concept that an increase in CO is a major contributor to exercise-induced hyperemia.

Published
2010
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