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1. Urine steroid metabolomics for the differential diagnosis of adrenal incidentalomas in the EURINE-ACT study: a prospective test validation study

Author

Glöckner, Stephan, Sinnott, Richard O., Stell, Anthony, Fragoso, Maria C., Kastelan, Darko, Pupovac, Ivana D., Simunov, Bojana, Cazenave, Sarah, Haissaguerre, Magalie, Tabarin, Antoine, Bertherat, Jérôme, Libé, Rossella, Kienitz, Tina, Quinkler, Marcus, Langton, Katharina, Eisenhofer, Graeme, Beuschlein, Felix, Brugger, Christina, Reincke, Martin, Riester, Anna, Spyroglou, Ariadni, Burger-Stritt, Stephanie, Deutschbein, Timo, Fassnacht, Martin, Hahner, Stefanie, Kroiss, Matthias, Ronchi, Cristina L., Palimeri, Sotiria, Tsagarakis, Stylianos, Tsirou, Ioanna, Vassiliadi, Dimitra A., Basile, Vittoria, Ingargiola, Elisa, Reimondo, Giuseppe, Terzolo, Massimo, Canu, Letizia, Mannelli, Massimo, Ettaieb, Hester, Haak, Harm R., Kerkhofs, Thomas M., Biehl, Michael, Feelders, Richard A., Hofland, Johannes, Hofland, Leo J., Grytaas, Marianne A., Husebye, Eystein S., Ueland, Grethe A., Ambroziak, Urszula, Bednarczuk, Tomasz, Kondracka, Agnieszka, Macech, Magdalena, Zawierucha, Malgorzata, Paiva, Isabel, Dennedy, M. Conall, Sajwani, Ahmed, Sherlock, Mark, Crowley, Rachel K., Ivovic, Miomira, Marina, Ljiljana, Deeks, Jonathan J., Sitch, Alice J., Arlt, Wiebke, Bancos, Irina, Chortis, Vasileios, Giligan, Lorna C., Hughes, Beverly A., Lang, Katharina, Ivison, Hannah E., Jenkinson, Carl, Manolopoulos, Konstantinos, O'Neil, Donna M., O'Reilly, Michael W., Papathomas, Thomas G., Prete, Alessandro, Shackleton, Cedric H.L., Taylor, Angela E., Asia, Miriam, Sutcliffe, Robert P., Guest, Peter, Skordilis, Kassiani, Bancos, Cristian, Chang, Alice, Davidge-Pitts, Caroline J., Delivanis, Danae A., Erickson, Dana, Natt, Neena, Nippoldt, Todd B., Thomas, Melinda, Young Jr., William F., Taylor, Angela E, Sitch, Alice J, Davidge-Pitts, Caroline J, Pupovac, Ivana D, Papathomas, Thomas G, Gilligan, Lorna C, Grytaas, Marianne A, Ivison, Hannah E, Shackleton, Cedric H L, Ronchi, Cristina L, Delivanis, Danae A, Sutcliffe, Robert P, Feelders, Richard A, Haak, Harm R, Dennedy, M Conall, Ueland, Grethe A, Vassiliadi, Dimitra A, O'Reilly, Michael W, Young, William F, Jr, and Deeks, Jonathan J

Published
2020
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3. Clinical and imaging presentations are associated with function in incidental adrenocortical adenomas: a retrospective cohort study.

Author

Hamidi, Oksana, Shah, Muhammad, Zhang, Catherine D, Lazik, Natalia, Li, Dingfeng, Singh, Sumitabh, Iñiguez-Ariza, Nicole M, Raman, Ram, Hurtado, Maria D, Carafone, Lindsay, Khanna, Aakanksha, Yan, Qi, Natt, Neena, Hartman, Robert P, McKenzie, Travis, Young, William F, and Bancos, Irina

Abstract

Objective The aim of this study is to assess whether clinical and imaging characteristics are associated with the hormonal subtype, growth, and adrenalectomy for incidental adrenal cortical adenomas (ACAs). Design This is a single-center cohort study. Methods Consecutive adult patients with incidental ACA were diagnosed between 2000 and 2016. Results Of the 1516 patients with incidental ACA (median age 59 years, 62% women), 699 (46%) had nonfunctioning adenomas (NFAs), 482 (31%) had mild autonomous cortisol secretion (MACS), 62 (4%) had primary aldosteronism (PA), 39 (3%) had Cushing syndrome, 18 (1%) had PA and MACS, and 226 (15%) had incomplete work-up. Age, sex, tumor size, and tumor laterality, but not unenhanced computed tomography Hounsfield units (HU), were associated with hormonal subtypes. In a multivariable analysis, ≥1 cm growth was associated with younger age (odds ratio [OR] = 0.8 per 5-year increase, P =.0047) and longer imaging follow-up (OR = 1.2 per year, P <.0001). Adrenalectomy was performed in 355 (23%) patients, including 38% of MACS and 15% of NFA. Adrenalectomy for NFA and MACS was more common in younger patients (OR = 0.79 per 5-year increase, P =.002), larger initial tumor size (OR = 2.3 per 1 cm increase, P <.0001), ≥1 cm growth (OR = 15.3, P <.0001), and higher postdexamethasone cortisol (OR = 6.6 for >5 vs <1.8 μg/dL, P =.002). Conclusions Age, sex, tumor size, and laterality were associated with ACA hormonal subtype and can guide diagnosis and management. Tumor growth was more common with younger age and longer follow-up. Unenhanced HU did not predict hormonal subtype or growth. Adrenalectomy for MACS and NFA was mainly performed in younger patients with larger tumor size, growth, and elevated postdexamethasone cortisol. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Hypoglycemia

Author

Natt, Neena, Service, F. John, Conn, P. Michael, editor, and Molitch, Mark E., editor

Published
2002
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19. Surgery for Cushing’s Syndrome: An Historical Review and Recent Ten-year Experience

Author

Porterfield, John R., Thompson, Geoffrey B., Young, Jr., William F., Chow, John T., Fryrear, Raymond S., van Heerden, Jon A., Farley, David R., Atkinson, John L. D., Meyer, Fredric B., Abboud, Charles F., Nippoldt, Todd B., Natt, Neena, Erickson, Dana, Vella, Adrian, Carpenter, Paul C., Richards, Melanie, Carney, J. Aidan, Larson, Dirk, Schleck, Cathy, Churchward, Marilyn, and Grant, Clive S.

Published
2008
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24. Urine steroid metabolomics for the differential diagnosis of adrenal incidentalomas in the EURINE-ACT study: a prospective test validation study

Author

Bancos, Irina, primary, Taylor, Angela E, additional, Chortis, Vasileios, additional, Sitch, Alice J, additional, Jenkinson, Carl, additional, Davidge-Pitts, Caroline J, additional, Lang, Katharina, additional, Tsagarakis, Stylianos, additional, Macech, Magdalena, additional, Riester, Anna, additional, Deutschbein, Timo, additional, Pupovac, Ivana D, additional, Kienitz, Tina, additional, Prete, Alessandro, additional, Papathomas, Thomas G, additional, Gilligan, Lorna C, additional, Bancos, Cristian, additional, Reimondo, Giuseppe, additional, Haissaguerre, Magalie, additional, Marina, Ljiljana, additional, Grytaas, Marianne A, additional, Sajwani, Ahmed, additional, Langton, Katharina, additional, Ivison, Hannah E, additional, Shackleton, Cedric H L, additional, Erickson, Dana, additional, Asia, Miriam, additional, Palimeri, Sotiria, additional, Kondracka, Agnieszka, additional, Spyroglou, Ariadni, additional, Ronchi, Cristina L, additional, Simunov, Bojana, additional, Delivanis, Danae A, additional, Sutcliffe, Robert P, additional, Tsirou, Ioanna, additional, Bednarczuk, Tomasz, additional, Reincke, Martin, additional, Burger-Stritt, Stephanie, additional, Feelders, Richard A, additional, Canu, Letizia, additional, Haak, Harm R, additional, Eisenhofer, Graeme, additional, Dennedy, M Conall, additional, Ueland, Grethe A, additional, Ivovic, Miomira, additional, Tabarin, Antoine, additional, Terzolo, Massimo, additional, Quinkler, Marcus, additional, Kastelan, Darko, additional, Fassnacht, Martin, additional, Beuschlein, Felix, additional, Ambroziak, Urszula, additional, Vassiliadi, Dimitra A, additional, O'Reilly, Michael W, additional, Young, William F, additional, Biehl, Michael, additional, Deeks, Jonathan J, additional, Arlt, Wiebke, additional, Glöckner, Stephan, additional, Sinnott, Richard O., additional, Stell, Anthony, additional, Fragoso, Maria C., additional, Pupovac, Ivana D., additional, Cazenave, Sarah, additional, Bertherat, Jérôme, additional, Libé, Rossella, additional, Brugger, Christina, additional, Hahner, Stefanie, additional, Kroiss, Matthias, additional, Ronchi, Cristina L., additional, Vassiliadi, Dimitra A., additional, Basile, Vittoria, additional, Ingargiola, Elisa, additional, Mannelli, Massimo, additional, Ettaieb, Hester, additional, Haak, Harm R., additional, Kerkhofs, Thomas M., additional, Feelders, Richard A., additional, Hofland, Johannes, additional, Hofland, Leo J., additional, Grytaas, Marianne A., additional, Husebye, Eystein S., additional, Ueland, Grethe A., additional, Zawierucha, Malgorzata, additional, Paiva, Isabel, additional, Dennedy, M. Conall, additional, Sherlock, Mark, additional, Crowley, Rachel K., additional, Deeks, Jonathan J., additional, Sitch, Alice J., additional, Bancos, Irina, additional, Giligan, Lorna C., additional, Hughes, Beverly A., additional, Ivison, Hannah E., additional, Manolopoulos, Konstantinos, additional, O'Neil, Donna M., additional, O'Reilly, Michael W., additional, Papathomas, Thomas G., additional, Shackleton, Cedric H.L., additional, Taylor, Angela E., additional, Sutcliffe, Robert P., additional, Guest, Peter, additional, Skordilis, Kassiani, additional, Chang, Alice, additional, Davidge-Pitts, Caroline J., additional, Delivanis, Danae A., additional, Natt, Neena, additional, Nippoldt, Todd B., additional, Thomas, Melinda, additional, and Young Jr., William F., additional

Published
2020
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34. Improvement of cardiovascular risk factors after adrenalectomy in patients with adrenal tumors and subclinical Cushing's syndrome: A systematic review and meta-Analysis

Author

Bancos, Irina, Alahdab, Fares, Crowley, Rachel K., Chortis, Vasileios, Delivanis, Danae A., Erickson, Dana, Natt, Neena, Terzolo, Massimo, Arlt, Wiebke, Young, William F., and Murad, M. Hassan

Subjects
Diabetes and Metabolism, Endocrinology, Cardiovascular Diseases, Risk Factors, Adrenal Gland Neoplasms, Humans, Adrenalectomy, Cushing Syndrome, Follow-Up Studies, Endocrinology, Diabetes and Metabolism
Published
2016

38. THERAPY OF ENDOCRINE DISEASE: Improvement of cardiovascular risk factors after adrenalectomy in patients with adrenal tumors and subclinical Cushing’s syndrome: a systematic review and meta-analysis

Author

Bancos, Irina, primary, Alahdab, Fares, additional, Crowley, Rachel K, additional, Chortis, Vasileios, additional, Delivanis, Danae A, additional, Erickson, Dana, additional, Natt, Neena, additional, Terzolo, Massimo, additional, Arlt, Wiebke, additional, Young, William F, additional, and Murad, M Hassan, additional

Published
2016
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44. Diagnostic performance of unenhanced computed tomography and 18F-fluorodeoxyglucose positron emission tomography in indeterminate adrenal tumours.

Author

Delivanis, Danae A., Bancos, Irina, Atwell, Thomas D., Schmit, Grant D., Eiken, Patrick W., Natt, Neena, Erickson, Dana, Maraka, Spyridoula, Young, William F., and Nathan, Mark A.

Subjects
COMPUTED tomography, FLUORODEOXYGLUCOSE F18, DIAGNOSTIC imaging, ADRENALECTOMY, CANCER patients
Abstract

Objective Evidence on the diagnostic performance of adrenal imaging is limited. We aimed to assess the diagnostic performance of unenhanced computed tomography ( CT) and 18F-fluorodeoxyglucose (18FDG) positron emission tomography ( PET)/ CT imaging in a high-risk population for adrenal malignancy using an optimal reference standard. Design Retrospective cohort study. Methods Imaging studies of patients with adrenal nodules who underwent adrenal biopsy and/or adrenalectomy between 1994 and 2014 were reviewed and compared to the reference standard of histology. Eighty % of patients presented with known or suspected extra-adrenal malignancy. Results Unenhanced abdominal CT was performed in 353 patients with adrenal lesions; median size was 3 (0.7-15) cm and median radiodensity was 33 (−21-78) Hounsfield units ( HU). Radiodensity of >10 HU diagnosed malignancy with a sensitivity of 100%, specificity of 33%, positive predictive value ( PPV) of 72% and negative predictive value ( NPV) of 100%. 18 FDG- PET/ CT was performed in 89 patients; median tumour size was 2.1 (0.7-9.2) cm. Maximum standardized uptake ( SUV max) was higher in malignant lesions when compared to benign lesions (median=10 [2.3-29.4] vs 3.7 [1.4-24.5], respectively, P<.0001). Similarly, median SUV max lesion to SUV max liver ratio ( ALR) in malignant lesions was higher than in benign lesions (median=3 [0.74-13.4] vs 1.2 [0.5-6.6], respectively, P<.0001). 18 FDG- PET/ CT ALR >1.8 diagnosed malignancy with a sensitivity of 87%, specificity of 84%, PPV of 85% and NPV of 86%. Conclusion Noncontract CT radiodensity of ≤10 HU excludes malignancy even in a high-risk population. For indeterminate adrenal lesions, given a superior specificity, 18 FDG- PET/ CT could be considered as a second stage imaging study. [ABSTRACT FROM AUTHOR]

Published
2018
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46. THERAPY IN ENDOCRINE DISEASE: Body composition and quality of life in adults treated with GH therapy: a systematic review and meta-analysis

Author

Hazem, Ahmad, primary, Elamin, Mohamed B, additional, Bancos, Irina, additional, Malaga, German, additional, Prutsky, Gabriela, additional, Domecq, Juan Pablo, additional, Elraiyah, Tarig A, additional, Abu Elnour, Nisrin O, additional, Prevost, Yolanda, additional, Almandoz, Jaime P, additional, Zeballos-Palacios, Claudia, additional, Velasquez, Edgar R, additional, Erwin, Patricia J, additional, Natt, Neena, additional, Montori, Victor M, additional, and Murad, Mohammad Hassan, additional

Published
2012
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48. 3 Tesla magnetic resonance imaging with and without corticotropin releasing hormone stimulation for the detection of microadenomas in Cushing’s syndrome

Author

Erickson, Dana, primary, Erickson, Bradley, additional, Watson, Robert, additional, Patton, Alice, additional, Atkinson, John, additional, Meyer, Fredric, additional, Nippoldt, Todd, additional, Carpenter, Paul, additional, Natt, Neena, additional, Vella, Adrian, additional, and Thapa, Prabin, additional

Published
2009
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