775 results on '"Naud, P"'
Search Results
2. Early fasting does not impact gonadal size nor vasa gene expression in the European seabass Dicentrarchus labrax
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Geffroy, Benjamin, Goikoetxea, Alexander, Villain-Naud, Nadège, and Martinez, Anne-Sophie
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- 2024
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3. Zéro allergie research clinic: a clinical and research initiative in oral immunotherapy for managing IgE-mediated food allergy
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Bénédicte L. Tremblay, Philippe Bégin, Frédérique Gagnon-Brassard, Anne-Marie Boucher-Lafleur, Marie-Ève Lavoie, Anne-Marie Madore, Sarah Lavoie, Cloé Rochefort-Beaudoin, Claudia Nuncio-Naud, Charles Morin, Guy Parizeault, and Catherine Laprise
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Asthma Desensitization ,Epigenetics ,Food allergy ,Genetics ,Gene expression ,Metabolomics ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract Background and methods The Zéro allergie research clinic (Saguenay, Canada) is a clinical and research initiative in oral immunotherapy (OIT) for managing IgE-mediated food allergy (FA). A total of 183 children with FA and 27 non-allergic siblings were recruited to date in the Zéro allergie cohort (ZAC) to better understand biological mechanisms underlying FA and OIT prognosis. The primary aims are to (a) better understand the genetic, epigenetic, transcriptomic, metabolomic, and microbial diversity associated with FA; (b) establish the multi-omics and microbial diversity profiles of children following OIT to identify predictive prognosis biomarkers, (c) make OIT more accessible to the population of the Saguenay–Lac-Saint-Jean region, and (d) build a biobank of data and biological material. Results The ZAC constitutes a unique and rich biobank of biological samples (blood, buccal swabs, microbiota samples [intestinal, buccal, nasal, and cutaneous]) combined with clinical data and more than 75 phenotypic characteristics. Conclusions This represents an innovative interdisciplinary initiative by researchers, allergists, and paediatricians to make FA care accessible to a greater number of children with IgE-mediated FA. Ultimately, it will contribute to provide more accessible treatment options with greater chances of success through a better understanding of the biological nature of FA and OIT.
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- 2024
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4. Expert elicitation of state shifts and divergent sensitivities to climate warming across northern ecosystems
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Émilie Saulnier-Talbot, Éliane Duchesne, Dermot Antoniades, Dominique Arseneault, Christine Barnard, Dominique Berteaux, Najat Bhiry, Frédéric Bouchard, Stéphane Boudreau, Kevin Cazelles, Jérôme Comte, Madeleine-Zoé Corbeil-Robitaille, Steeve D. Côté, Raoul-Marie Couture, Guillaume de Lafontaine, Florent Domine, Dominique Fauteux, Daniel Fortier, Michelle Garneau, Gilles Gauthier, Dominique Gravel, Isabelle Laurion, Martin Lavoie, Nicolas Lecomte, Pierre Legagneux, Esther Lévesque, Marie-José Naud, Michel Paquette, Serge Payette, Reinhard Pienitz, Milla Rautio, Alexandre Roy, Alain Royer, Martin Simard, Warwick F. Vincent, and Joël Bêty
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Geology ,QE1-996.5 ,Environmental sciences ,GE1-350 - Abstract
Abstract Northern regions are warming faster than the rest of the globe. It is difficult to predict ecosystem responses to warming because the thermal sensitivity of their biophysical components varies. Here, we present an analysis of the authors’ expert judgment regarding the sensitivity of six ecosystem components – permafrost, peatlands, lakes, snowpack, vegetation, and endothermic vertebrates – across northern landscapes ranging from boreal to polar biomes. We identified 28 discontinuous component states across a 3700 km latitudinal gradient in northeastern North America and quantified sensitivity as the transition time from an initial to a contrasting state following a theoretical step change increase in mean annual air temperature of 5 °C. We infer that multiple interconnected state shifts are likely to occur within a narrow subarctic latitudinal band at timescales of 10 to more than 100 years, and response times decrease with latitude. Response times differ between components and across latitudes, which is likely to impair the integrity of ecosystems.
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- 2024
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5. Gut microbiota drives colon cancer risk associated with diet: a comparative analysis of meat-based and pesco-vegetarian diets
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Carlotta De Filippo, Sofia Chioccioli, Niccolò Meriggi, Antonio Dario Troise, Francesco Vitali, Mariela Mejia Monroy, Serdar Özsezen, Katia Tortora, Aurélie Balvay, Claire Maudet, Nathalie Naud, Edwin Fouché, Charline Buisson, Jacques Dupuy, Valérie Bézirard, Sylvie Chevolleau, Valérie Tondereau, Vassilia Theodorou, Claire Maslo, Perrine Aubry, Camille Etienne, Lisa Giovannelli, Vincenzo Longo, Andrea Scaloni, Duccio Cavalieri, Jildau Bouwman, Fabrice Pierre, Philippe Gérard, Françoise Guéraud, and Giovanna Caderni
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Microbial ecology ,QR100-130 - Abstract
Abstract Background Colorectal cancer (CRC) risk is strongly affected by dietary habits with red and processed meat increasing risk, and foods rich in dietary fibres considered protective. Dietary habits also shape gut microbiota, but the role of the combination between diet, the gut microbiota, and the metabolite profile on CRC risk is still missing an unequivocal characterisation. Methods To investigate how gut microbiota affects diet-associated CRC risk, we fed Apc-mutated PIRC rats and azoxymethane (AOM)-induced rats the following diets: a high-risk red/processed meat-based diet (MBD), a normalised risk diet (MBD with α-tocopherol, MBDT), a low-risk pesco-vegetarian diet (PVD), and control diet. We then conducted faecal microbiota transplantation (FMT) from PIRC rats to germ-free rats treated with AOM and fed a standard diet for 3 months. We analysed multiple tumour markers and assessed the variations in the faecal microbiota using 16S rRNA gene sequencing together with targeted- and untargeted-metabolomics analyses. Results In both animal models, the PVD group exhibited significantly lower colon tumorigenesis than the MBD ones, consistent with various CRC biomarkers. Faecal microbiota and its metabolites also revealed significant diet-dependent profiles. Intriguingly, when faeces from PIRC rats fed these diets were transplanted into germ-free rats, those transplanted with MBD faeces developed a higher number of preneoplastic lesions together with distinctive diet-related bacterial and metabolic profiles. PVD determines a selection of nine taxonomic markers mainly belonging to Lachnospiraceae and Prevotellaceae families exclusively associated with at least two different animal models, and within these, four taxonomic markers were shared across all the three animal models. An inverse correlation between nonconjugated bile acids and bacterial genera mainly belonging to the Lachnospiraceae and Prevotellaceae families (representative of the PVD group) was present, suggesting a potential mechanism of action for the protective effect of these genera against CRC. Conclusions These results highlight the protective effects of PVD while reaffirming the carcinogenic properties of MBD diets. In germ-free rats, FMT induced changes reminiscent of dietary effects, including heightened preneoplastic lesions in MBD rats and the transmission of specific diet-related bacterial and metabolic profiles. Importantly, to the best of our knowledge, this is the first study showing that diet-associated cancer risk can be transferred with faeces, establishing gut microbiota as a determinant of diet-associated CRC risk. Therefore, this study marks the pioneering demonstration of faecal transfer as a means of conveying diet-related cancer risk, firmly establishing the gut microbiota as a pivotal factor in diet-associated CRC susceptibility. Video Abstract
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- 2024
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6. Zéro allergie research clinic: a clinical and research initiative in oral immunotherapy for managing IgE-mediated food allergy
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Tremblay, Bénédicte L., Bégin, Philippe, Gagnon-Brassard, Frédérique, Boucher-Lafleur, Anne-Marie, Lavoie, Marie-Ève, Madore, Anne-Marie, Lavoie, Sarah, Rochefort-Beaudoin, Cloé, Nuncio-Naud, Claudia, Morin, Charles, Parizeault, Guy, and Laprise, Catherine
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- 2024
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7. Expert elicitation of state shifts and divergent sensitivities to climate warming across northern ecosystems
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Saulnier-Talbot, Émilie, Duchesne, Éliane, Antoniades, Dermot, Arseneault, Dominique, Barnard, Christine, Berteaux, Dominique, Bhiry, Najat, Bouchard, Frédéric, Boudreau, Stéphane, Cazelles, Kevin, Comte, Jérôme, Corbeil-Robitaille, Madeleine-Zoé, Côté, Steeve D., Couture, Raoul-Marie, de Lafontaine, Guillaume, Domine, Florent, Fauteux, Dominique, Fortier, Daniel, Garneau, Michelle, Gauthier, Gilles, Gravel, Dominique, Laurion, Isabelle, Lavoie, Martin, Lecomte, Nicolas, Legagneux, Pierre, Lévesque, Esther, Naud, Marie-José, Paquette, Michel, Payette, Serge, Pienitz, Reinhard, Rautio, Milla, Roy, Alexandre, Royer, Alain, Simard, Martin, Vincent, Warwick F., and Bêty, Joël
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- 2024
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8. Gut microbiota drives colon cancer risk associated with diet: a comparative analysis of meat-based and pesco-vegetarian diets
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De Filippo, Carlotta, Chioccioli, Sofia, Meriggi, Niccolò, Troise, Antonio Dario, Vitali, Francesco, Mejia Monroy, Mariela, Özsezen, Serdar, Tortora, Katia, Balvay, Aurélie, Maudet, Claire, Naud, Nathalie, Fouché, Edwin, Buisson, Charline, Dupuy, Jacques, Bézirard, Valérie, Chevolleau, Sylvie, Tondereau, Valérie, Theodorou, Vassilia, Maslo, Claire, Aubry, Perrine, Etienne, Camille, Giovannelli, Lisa, Longo, Vincenzo, Scaloni, Andrea, Cavalieri, Duccio, Bouwman, Jildau, Pierre, Fabrice, Gérard, Philippe, Guéraud, Françoise, and Caderni, Giovanna
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- 2024
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9. Calcium-rich dairy matrix protects better than mineral calcium against colonic luminal haem-induced alterations in male rats
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Olier, Maïwenn, Naud, Nathalie, Fouché, Edwin, Tondereau, Valérie, Ahn, Ingrid, Leconte, Nadine, Blas-Y-Estrada, Florence, Garric, Gilles, Heliès-Toussaint, Cécile, Harel-Oger, Marielle, Marmonier, Corinne, Théodorou, Vassilia, Guéraud, Françoise, Jan, Gwénaël, and Pierre, Fabrice
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- 2024
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10. Relationship between employment and quality of life and self-perceived health in people with spinal cord injury: an international comparative study based on the InSCI Community Survey
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Escorpizo, Reuben, Naud, Shelly, Post, Marcel W. M., Schwegler, Urban, Engkasan, Julia, Halvorsen, Annette, Geraghty, Timothy, and Sadowsky, Cristina
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- 2024
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11. Connecting levels of analysis in the computational era
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Naud, Richard and Longtin, André
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Quantitative Biology - Neurons and Cognition - Abstract
Neuroscience and artificial intelligence are closely intertwined, but so are the physics of dynamical system, philosophy and psychology. Each of these fields try in their own way to relate observations at the level of molecules, synapses, neurons or behavior, to a function. An influential conceptual approach to this end was popularized by David Marr, which focused on the interaction between three theoretical 'levels of analysis'. With the convergence of simulation-based approaches, algorithm-oriented Neuro-AI and high-throughput data, we currently see much research organized around four levels of analysis: observations, models, algorithms and functions. Bidirectional interaction between these levels influences how we undertake interdisciplinary science., Comment: neuroscience, cognitive neuroscience, computational neuroscience, machine learning, artificial intelligence, philosophy
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- 2023
12. Calcium-rich dairy matrix protects better than mineral calcium against colonic luminal haem-induced alterations in male rats
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Maïwenn Olier, Nathalie Naud, Edwin Fouché, Valérie Tondereau, Ingrid Ahn, Nadine Leconte, Florence Blas-Y-Estrada, Gilles Garric, Cécile Heliès-Toussaint, Marielle Harel-Oger, Corinne Marmonier, Vassilia Théodorou, Françoise Guéraud, Gwénaël Jan, and Fabrice Pierre
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Nutrition. Foods and food supply ,TX341-641 ,Food processing and manufacture ,TP368-456 - Abstract
Abstract The haemoglobin content in meat is consistently associated with an increased risk of colorectal cancer, whereas calcium may play a role as a chemopreventive agent. Using rodent models, calcium salts have been shown to prevent the promotion of haem-induced and red meat-induced colorectal carcinogenesis by limiting the bioavailability of the gut luminal haem iron. Therefore, this study aimed to compare impacts of dietary calcium provided as calcium salts or dairy matrix on gut homoeostasis perturbations by high haeminic or non-haeminic iron intakes. A 3-week intervention study was conducted using Fischer 344 rats. Compared to the ferric citrate-enriched diet, the haemoglobin-enriched diet led to increased faecal, mucosal, and urinary lipoperoxidation-related biomarkers, resulting from higher gut luminal haem iron bioavailability. This redox imbalance was associated to a dysbiosis of faecal microbiota. The addition of calcium to haemoglobin-enriched diets limited haem iron bioavailability and counteracted redox imbalance, with improved preventive efficacy when calcium was provided in dairy matrix. Data integration revealed correlations between haem-induced lipoperoxidation products and bacterial communities belonging to Peptococcaceae, Eubacterium coprostanoligenes group, and Bifidobacteriaceae. This integrated approach provides evidence of the benefits of dairy matrix as a dietary calcium vehicle to counteract the deleterious side-effects of meat consumption.
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- 2024
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13. Silences, Spikes and Bursts: Three-Part Knot of the Neural Code
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Naud, Richard, Friedenberger, Zachary, and Toth, Katalin
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Quantitative Biology - Neurons and Cognition - Abstract
When a neuron breaks silence, it can emit action potentials in a number of patterns. Some responses are so sudden and intense that electrophysiologists felt the need to single them out, labeling action potentials emitted at a particularly high frequency with a metonym -- bursts. Is there more to bursts than a figure of speech? After all, sudden bouts of high-frequency firing are expected to occur whenever inputs surge. The burst coding hypothesis advances that the neural code has three syllables: silences, spikes and bursts. We review evidence supporting this ternary code in terms of devoted mechanisms for burst generation, synaptic transmission and synaptic plasticity. We also review the learning and attention theories for which such a triad is beneficial., Comment: 15 pages, 4 figures
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- 2023
14. Determinants of Laplacians on random hyperbolic surfaces
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Naud, Frédéric
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Mathematics - Spectral Theory ,Mathematics - Differential Geometry - Abstract
We investigate the behaviour of the regularized determinant of the Laplace-Beltrami operator on compact hyperbolic surfaces when the genus goes to infinity. We show that for all popular models of random surfaces, with high probability as the genus goes to infinity, the determinant has an exponential growth with a universal exponent. Limit results for some moments of the logarithm of the determinant are then derived., Comment: 20 pages, revised version
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- 2023
15. Transmon-qubit readout using in-situ bifurcation amplification in the mesoscopic regime
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Dassonneville, R., Ramos, T., Milchakov, V., Mori, C., Planat, L., Foroughi, F., Naud, C., Hasch-Guichard, W., Garcia-Ripoll, J. J., Roch, N., and Buisson, O.
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Quantum Physics ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
We demonstrate a transmon qubit readout based on the nonlinear response to a drive of polaritonic meters in-situ coupled to the qubit. Inside a 3D readout cavity, we place a transmon molecule consisting of a transmon qubit and an ancilla mode interacting via non-perturbative cross-Kerr coupling. The cavity couples strongly only to the ancilla mode, leading to hybridized lower and upper polaritonic meters. Both polaritons are anharmonic and dissipative, as they inherit a self-Kerr nonlinearity $U$ from the ancilla and effective decay $\kappa$ from the open cavity. Via the ancilla, the polariton meters also inherit the non-perturbative cross-Kerr coupling to the qubit. This results in a high qubit-dependent displacement $2\chi > \kappa, ~U$ that can be read out via the cavity without causing Purcell decay. Moreover, the polariton meters, being nonlinear resonators, present bistability, and bifurcation behavior when the probing power increases. In this work, we focus on the bifurcation at low power in the few-photon regime, called the mesoscopic regime, which is accessible when the self-Kerr and decay rates of the polariton meter are similar $U\sim \kappa$. Capitalizing on a latching mechanism by bifurcation, the readout is sensitive to transmon qubit relaxation error only in the first tens of nanoseconds. We thus report a single-shot fidelity of 98.6 $\%$ while having an integration time of a 500 ns and no requirement for an external quantum-limited amplifier.
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- 2022
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16. Random covers of compact surfaces and smooth linear spectral statistics
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Naud, Frédéric
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Mathematics - Spectral Theory ,Mathematics - Probability - Abstract
We consider random n-covers $X_n$ of an arbitrary compact hyperbolic surface $X$. We show that in the large n regime and small window limit, the variance of the smooth spectral statistics of the Laplacian twisted by a unitary abelian character, obey the universal laws of GOE and GUE random matrices, depending on wether the character preserves or breaks the time reversal symmetry. We also prove a generalization for higher dimensional twists valued in compact linear groups. These results confirm a conjecture of Berry and is a discrete analog of a recent work of Rudnick for the Weil-Petersson model of random surfaces., Comment: 22 pages
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- 2022
17. Dendritic excitability controls overdispersion
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Friedenberger, Zachary and Naud, Richard
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- 2024
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18. Revealing the finite-frequency response of a bosonic quantum impurity
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Léger, Sébastien, Sépulcre, Théo, Fraudet, Dorian, Buisson, Olivier, Naud, Cécile, Hasch-Guichard, Wiebke, Florens, Serge, Snyman, Izak, Basko, Denis M., and Roch, Nicolas
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Quantum Physics ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Quantum impurities are ubiquitous in condensed matter physics and constitute the most stripped-down realization of many-body problems. While measuring their finite-frequency response could give access to key characteristics such as excitations spectra or dynamical properties, this goal has remained elusive despite over two decades of studies in nanoelectronic quantum dots. Conflicting experimental constraints of very strong coupling and large measurement bandwidths must be met simultaneously. We get around this problem using cQED tools, and build a precisely characterized quantum simulator of the boundary sine-Gordon model, a non-trivial bosonic impurity problem. We succeeded to fully map out the finite frequency linear response of this system. Its reactive part evidences a strong renormalisation of the nonlinearity at the boundary in agreement with non-perturbative calculations. Its dissipative part reveals a dramatic many-body broadening caused by multi-photon conversion. The experimental results are matched quantitatively to a resummed diagrammatic calculation based on a microscopically calibrated model. Furthermore, we push the device into a regime where diagrammatic calculations break down, which calls for more advanced theoretical tools to model many-body quantum circuits. We also critically examine the technological limitations of cQED platforms to reach universal scaling laws. This work opens exciting perspectives for the future such as quantifying quantum entanglement in the vicinity of a quantum critical point or accessing the dynamical properties of non-trivial many-body problems., Comment: 39 pages, 14 figures. The final version clarifies the position of our study w.r.t previous works
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- 2022
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19. Evidence of dual Shapiro steps in a Josephson junctions array
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Crescini, Nicolò, Cailleaux, Samuel, Guichard, Wiebke, Naud, Cécile, Buisson, Olivier, Murch, Kater, and Roch, Nicolas
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Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Superconductivity ,Quantum Physics - Abstract
The modern primary voltage standard is based on the AC Josephson effect and the ensuing Shapiro steps, where a microwave tone applied to a Josephson junction yields a constant voltage $hf/2e$ ($h$ is Planck's constant and $e$ the electron charge) determined by only the microwave frequency $f$ and fundamental constants. Duality arguments for current and voltage have long suggested the possibility of dual Shapiro steps -- that a Josephson junction device could produce current steps with heights determined only on the applied frequency. In this report, we embed an ultrasmall Josephson junction in a high impedance array of larger junctions to reveal dual Shapiro steps. For multiple frequencies, we detect that the AC response of the circuit is synchronised with the microwave tone at frequency $f$, and the corresponding emergence of flat steps in the DC response with current $2ef$, equal to the tunnelling of a Cooper pair per tone period. This work sheds new light on phase-charge duality, omnipresent in condensed matter physics, and extends it to Josephson circuits. Looking forward, it opens a broad range of possibilities for new experiments in the field of circuit quantum electrodynamics and is an important step towards the long-sought closure of the quantum metrology electrical triangle., Comment: 14 pages, 11 figures
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- 2022
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20. Spray drift in viticulture: A dataset to analyse the influence of spray application techniques, hedges and their combination on the reduction of sedimentary drift, aerial drift and exposure of bystanders
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Adrien Vergès, Sébastien Codis, Elodie Trinquier, Benjamin Perriot, David Pasquier, Yoan Hudebine, Florence Verpont, Jean-Paul Douzals, Carole Bedos, Sonia Grimbuhler, Marianne Sellam, and Olivier Naud
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Grapevine ,Sprayer ,Airborne drift ,Drift mitigation ,Contamination risk ,Computer applications to medicine. Medical informatics ,R858-859.7 ,Science (General) ,Q1-390 - Abstract
In 2021 and 2022, the national and cross-sector project CAPRIV funded by the French Ministry of Agriculture, made it possible to assess the influence of application techniques associated or not with a hedge or an anti-drift net on spray drift and bystander exposure. The acronym CAPRIV stands for ''Concilier l'application des PPP et la protection des riverains'' (Reconciling the use of PPPs and the protection of residents), within the orchard, viticulture, and field crops sectors. This specific data article focuses on viticulture. In viticulture, over the two years, 10 different spray application techniques were tested. For 3 of them the influence of a hedge on drift mitigation was also evaluated. All the trials were conducted on the “EoleDrift” test bench, with an artificial vegetation and an artificial wind. Spray drift has been measured according to a common protocol harmonised between cropping sectors within the project using three different types of passive drift collectors that were set up downwind of the treated field. Petri dishes collected sedimentary drift, PVC wires collected airborne drift and cotton T-shirts placed on manikins were used to assess potential dermal exposure of bystanders. The plant protection mix was simulated by a dilution of a fluorescent dye in water. The collected mass of dye was measured using a classical technique with dilution and concentration evaluation. Two fluorescent dyes were successively used, Brillant Sulfaflavine and Sulforhodamine B. A total amount of 4770 collectors were analysed individually. The data set provides a drift index for each collector expressed as the quantity of dye recovered per unit area of collector on the quantity of dye applied per unit area on the sprayed field multiplied by 100.
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- 2024
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21. Technological innovations in vineyard spraying: assessment of PWM technology and future prospects
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Maude Lewis, Sébastien Codis, Xavier Delpuech, Xavier Ribeyrolles, Olivier Naud, and Adrien Vergès
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Agriculture (General) ,S1-972 ,Plant culture ,SB1-1110 - Abstract
The Institut Français de la Vigne et du Vin and INRAE have worked with the companies OPTIMA Concept and Berthoud to develop a high-precision digitally controlled sprayer that automatically adjusts the volume of spray delivered by each nozzle according to geo-referenced guidance maps. This paper describes the technical characteristics and performance of the solutions studied, and outlines the prospects for deploying these technologies in viticulture.
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- 2024
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22. Spray drift in field crops: A dataset to analyse the influence of air induction nozzles, hedges, and their combination on the reduction of sedimentary drift, aerial drift and exposure of bystanders
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Benjamin Perriot, David Pasquier, Yoan Hudebine, Florence Verpont, Adrien Vergès, Sébastien Codis, Jean-Paul Douzals, Carole Bedos, Sonia Grimbuhler, Marianne Sellam, and Olivier Naud
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Wheat ,Sprayer ,Airborne drift ,Drift mitigation ,Contamination risk ,Computer applications to medicine. Medical informatics ,R858-859.7 ,Science (General) ,Q1-390 - Abstract
In 2021 and 2022, the national and cross-sector project CAPRIV funded by the French Ministry of Agriculture, made it possible to assess the influence of application techniques associated or not with a hedge or an anti-drift net on spray drift and bystander exposure. The acronym CAPRIV stands for “Concilier l'application des PPP et la protection des riverains” (Reconciling the use of PPPs and the protection of residents), within the orchard, viticulture, and field crops sectors. This specific data article focuses on field crops, especially on wheat. Over the two years, one boom sprayer equipped with flat fan and air induction nozzles was used on wheat fields adjacent to a hedgerow (2022) or not (2021). Spray drift has been measured according to a common protocol harmonised between cropping sectors within the project. Three different types of passive drift collectors were set up downwind of the treated field: Petri dishes for sedimentary drift, PVC wires placed between two masts for airborne drift and cotton T-shirts placed on manikins to assess potential dermal exposure of bystanders. The sprayed mix contained a fluorescent dye diluted in water. The mass of dye was measured using a classical technique with dilution and concentration evaluation. Two fluorescent dyes were successively used, Brillant Sulfaflavine and Sulforhodamine B. A total amount of 3792 collectors were analyzed individually. The data set provides a drift index for each collector expressed as the quantity of dye recovered per unit area of collector on the quantity of dye applied per unit area on the sprayed field multiplied by 100.
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- 2024
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23. On the spectrum of twisted Laplacians and the Teichm\'uller representation
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Naud, Frédéric and Spilioti, Polyxeni
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Mathematics - Spectral Theory ,Mathematics - Dynamical Systems - Abstract
We consider Laplacians with non unitary twists acting on sections of flat vector bundles over compact hyperbolic surfaces. These non self-adjoint Laplacians have discrete spectrum inside a parabola in the complex plane. For representations of the fundamental group of the base surface which are of Teichm\"uller type, we investigate the high energy limit and give a precise description of the bulk of the spectrum where Weyl's law is satisfied in terms of critical exponents of the representations which are completely determined by the Manhattan curve associated to the Teichm\"uller deformation. Our main result provides a counting estimate for the eigenvalues outside the bulk with a polynomial improvement over Weyl's law., Comment: 33 pages, 4 figures. Added more relevant references and comments
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- 2022
24. The First High-Contrast Images of X-Ray Binaries: Detection of Candidate Companions in the $\gamma$ Cas Analog RX J1744.7$-$2713
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Prasow-Émond, M., Hlavacek-Larrondo, J., Fogarty, K., Rameau, J., Mawet, D., Guité, L. -S., Gandhi, P., Rao, A., Steiner, J., Artigau, É., Lafrenière, D., Fabian, A., Walton, D., Weiss, L., Doyon, R., Rhea, C. L., Bégin, T., Vigneron, B., and Naud, M. -E.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
X-ray binaries provide exceptional laboratories for understanding the physics of matter under the most extreme conditions. Until recently, there were few, if any, observational constraints on the circumbinary environments of X-ray binaries at $\sim$ 100-5000 AU scales; it remains unclear how the accretion onto the compact objects or the explosions giving rise to the compact objects interact with their immediate surroundings. Here, we present the first high-contrast adaptive optics images of X-ray binaries. These observations target all X-ray binaries within $\sim$ 3 kpc accessible with the Keck/NIRC2 vortex coronagraph. This paper focuses on one of the first key results from this campaign: our images reveal the presence of 21 sources potentially associated with the $\gamma$ Cassiopeiae analog high-mass X-ray binary RX J1744.7$-$2713. By conducting different analyses - a preliminary proper motion analysis, a color-magnitude diagram and a probability of chance alignment calculation - we found that three of these 21 sources have a high probability of being bound to the system. If confirmed, they would be in wide orbits ($\sim$ 450 AU to 2500 AU). While follow-up astrometric observations will be needed in $\sim$ 5-10 years to confirm further the bound nature of these detections, these discoveries emphasize that such observations may provide a major breakthrough in the field. In fact, they would be useful not only for our understanding of stellar multiplicity but also for our understanding of how planets, brown dwarfs and stars can form even in the most extreme environments., Comment: Accepted for publication in AJ
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- 2022
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25. Key Age-Friendly Components of Municipalities that Foster Social Participation of Aging Canadians: Results from the Canadian Longitudinal Study on Aging
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Levasseur, Mélanie, Dubois, Marie-France, Généreux, Mélissa, Naud, Daniel, Trottier, Lise, Menec, Verena, Roy, Mathieu, Gabaude, Catherine, Couturier, Yves, and Raina, Parminder
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- 2023
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26. The dlt motivic zeta function is not well-defined
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Nicaise, Johannes, Potemans, Naud, and Veys, Willem
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Mathematics - Algebraic Geometry - Abstract
In arXiv:1408.4708, Xu defines the dlt motivic zeta function associated to a regular function $f$ on a smooth variety $X$ over a field of characteristic zero. This is an adaptation of the classical motivic zeta function that was introduced by Denef and Loeser. The dlt motivic zeta function is defined on a dlt modification via a Denef-Loeser-type formula, replacing classes of strata in the Grothendieck ring of varieties by stringy motives. We provide explicit examples that show that the dlt motivic zeta function depends on the choice of dlt modification, contrary to what is claimed in arXiv:1408.4708, and that it is therefore not well-defined.
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- 2021
27. Observation of two-mode squeezing in a traveling wave parametric amplifier
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Esposito, Martina, Ranadive, Arpit, Planat, Luca, Leger, Sebastian, Fraudet, Dorian, Jouanny, Vincent, Buisson, Olivier, Guichard, Wiebke, Naud, Cécile, Aumentado, José, Lecocq, Florent, and Roch, Nicolas
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Quantum Physics - Abstract
Traveling wave parametric amplifiers (TWPAs) have recently emerged as essential tools for broadband near quantum-limited amplification. However, their use to generate microwave quantum states still misses an experimental demonstration. In this letter, we report operation of a TWPA as a source of two-mode squeezed microwave radiation. We demonstrate broadband entanglement generation between two modes separated by up to 400 MHz by measuring logarithmic negativity between 0.27 and 0.51 and collective quadrature squeezing below the vacuum limit between 1.5 and 2.1 dB. This work opens interesting perspectives for the exploration of novel microwave photonics experiments with possible applications in quantum sensing and continuous variable quantum computing., Comment: version accepted for publication
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- 2021
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28. Effects of sodium nitrite reduction, removal or replacement on cured and cooked meat for microbiological growth, food safety, colon ecosystem, and colorectal carcinogenesis in Fischer 344 rats
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Guéraud, Françoise, Buisson, Charline, Promeyrat, Aurélie, Naud, Nathalie, Fouché, Edwin, Bézirard, Valérie, Dupuy, Jacques, Plaisancié, Pascale, Héliès-Toussaint, Cécile, Trouilh, Lidwine, Martin, Jean-Luc, Jeuge, Sabine, Keuleyan, Eléna, Petit, Noémie, Aubry, Laurent, Théodorou, Vassilia, Frémaux, Bastien, Olier, Maïwenn, Caderni, Giovanna, Kostka, Tina, Nassy, Gilles, Santé-Lhoutellier, Véronique, and Pierre, Fabrice
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- 2023
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29. Just How River‐Like Are Atmospheric Rivers?
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A. N. LeGrande, J. F. Booth, C. M. Naud, C. Ordaz, and J. A. Crespo
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atmospheric rivers ,CYGNSS ,water tracers ,air sea fluxes ,Geophysics. Cosmic physics ,QC801-809 - Abstract
Abstract Atmospheric Rivers (ARs) are synoptic‐scale conduits for poleward transport of heat and water, often associated with extreme rainfall. Using NASA surface heat flux observations and climate model simulations, we assess whether ARs are “rivers”, transporting heat and moisture over longer distances, or mostly local convergence. The observations indicate that ARs reduce extratropical surface energy fluxes, even during early development. This damping of surface fluxes during ARs is also simulated in the Goddard Institute for Space Studies ModelE, 2.1 (GISS‐E2.1) nudged to (MERRA2) reanalysis winds. Furthermore, water provenance tracers in GISS‐E2.1 identify the moisture source for ∼7,500 ARs globally during 2018–2022 as farther upstream and equatorward compared to climatology. These results quantitatively show that ARs source relatively less moisture from the surface beneath them and more from a greater distance than during non‐AR times.
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- 2024
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30. Extension of Alon's and Friedman's conjectures to Schottky surfaces
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Magee, Michael and Naud, Frédéric
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Mathematics - Spectral Theory ,Mathematics - Analysis of PDEs ,Mathematics - Probability ,58J50, 35B34, 05C80, 05C50 - Abstract
Let $X=\Lambda\backslash\mathbb{H}$ be a Schottky surface, that is, a conformally compact hyperbolic surface of infinite area. Let $\delta$ denote the Hausdorff dimension of the limit set of $\Lambda$. We prove that for any compact subset $\mathcal{K} \subset\{\,s\,:\,\Re(s)>\frac{\delta}{2}\,\}$, if one picks a random degree $n$ cover $X_{n}$ of $X$ uniformly at random, then with probability tending to one as $n\to\infty$, there are no resonances of $X_{n}$ in $\mathcal{K}$ other than those already belonging to $X$ (and with the same multiplicity). This result is conjectured to be the optimal one for bounded frequency resonances and is analogous to both Alon's and Friedman's conjectures for random graphs, which are now theorems due to Friedman and Bordenave-Collins, respectively., Comment: 34 pages, this version: fixed typos and minor change to Introduction
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- 2021
31. Effects of sodium nitrite reduction, removal or replacement on cured and cooked meat for microbiological growth, food safety, colon ecosystem, and colorectal carcinogenesis in Fischer 344 rats
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Françoise Guéraud, Charline Buisson, Aurélie Promeyrat, Nathalie Naud, Edwin Fouché, Valérie Bézirard, Jacques Dupuy, Pascale Plaisancié, Cécile Héliès-Toussaint, Lidwine Trouilh, Jean-Luc Martin, Sabine Jeuge, Eléna Keuleyan, Noémie Petit, Laurent Aubry, Vassilia Théodorou, Bastien Frémaux, Maïwenn Olier, Giovanna Caderni, Tina Kostka, Gilles Nassy, Véronique Santé-Lhoutellier, and Fabrice Pierre
- Subjects
Nutrition. Foods and food supply ,TX341-641 ,Food processing and manufacture ,TP368-456 - Abstract
Abstract Epidemiological and experimental evidence indicated that processed meat consumption is associated with colorectal cancer risks. Several studies suggest the involvement of nitrite or nitrate additives via N-nitroso-compound formation (NOCs). Compared to the reference level (120 mg/kg of ham), sodium nitrite removal and reduction (90 mg/kg) similarly decreased preneoplastic lesions in F344 rats, but only reduction had an inhibitory effect on Listeria monocytogenes growth comparable to that obtained using the reference nitrite level and an effective lipid peroxidation control. Among the three nitrite salt alternatives tested, none of them led to a significant gain when compared to the reference level: vegetable stock, due to nitrate presence, was very similar to this reference nitrite level, yeast extract induced a strong luminal peroxidation and no decrease in preneoplastic lesions in rats despite the absence of NOCs, and polyphenol rich extract induced the clearest downward trend on preneoplastic lesions in rats but the concomitant presence of nitrosyl iron in feces. Except the vegetable stock, other alternatives were less efficient than sodium nitrite in reducing L. monocytogenes growth.
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- 2023
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32. Evidence of dual Shapiro steps in a Josephson junction array
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Crescini, Nicolò, Cailleaux, Samuel, Guichard, Wiebke, Naud, Cécile, Buisson, Olivier, W. Murch, Kater, and Roch, Nicolas
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- 2023
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33. How robust and persistent are intuitive conceptions? Insights from production tasks
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Gvozdic, Katarina, NAUD, Stéphanie, and Sander, Emmanuel
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Education ,Psychology ,Instruction and teaching - Abstract
Intuitive conceptions are prevalent among young learners and can impose constraints to knowledge acquisition. Even though the data suggests that instruction does not eradicate them, this phenomenon has rarely been quantified. In this study we raise the question of how robust intuitive conceptions are. Moreover, we look at their persistence long after instruction of the studied notions. Production tasks concerning the four elementary arithmetic operations were used for measuring the degree to which they prevail and impose constraints among adults, 131 bachelor students as well as 168 high-school teachers and 57 mathematics teachers. The findings revealed that in most cases (88.93%) participants evoked examples that are congruent with an intuitive conception. This was observed for all the arithmetic operations and populations involved in the study. Even when explicitly prompted to find incongruent cases, they failed on two thirds of the cases. The educational entailments of these findings are discussed.
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- 2022
34. Kerr reversal in Josephson meta-material and traveling wave parametric amplification
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Ranadive, Arpit, Esposito, Martina, Planat, Luca, Bonet, Edgar, Naud, Cécile, Buisson, Olivier, Guichard, Wiebke, and Roch, Nicolas
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Quantum Physics ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Josephson meta-materials have recently emerged as very promising platform for superconducting quantum science and technologies. Their distinguishing potential resides in ability to engineer them at sub-wavelength scales, which allows complete control over wave dispersion and nonlinear interaction. In this article we report a versatile Josephson transmission line with strong third order nonlinearity which can be tuned from positive to negative values, and suppressed second order non linearity. As an initial implementation of this multipurpose meta-material, we operate it to demonstrate reversed Kerr phase-matching mechanism in traveling wave parametric amplification. Compared to previous state of the art phase matching approaches, this reversed Kerr phase matching avoids the presence of gaps in transmission, can reduce gain ripples, and allows in situ tunability of the amplification band over an unprecedented wide range. Besides such notable advancements in the amplification performance with direct applications to superconducting quantum computing and generation of broadband squeezing, the in-situ tunability with sign reversal of the nonlinearity in traveling wave structures, with no counterpart in optics to the best of our knowledge, opens exciting experimental possibilities in the general framework of microwave quantum optics, single-photon detection and quantum limited amplification.
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- 2021
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35. Functional subtypes of synaptic dynamics in mouse and human
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John Beninger, Julian Rossbroich, Katalin Tóth, and Richard Naud
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CP: Neuroscience ,CP: Cell biology ,Biology (General) ,QH301-705.5 - Abstract
Summary: Synapses preferentially respond to particular temporal patterns of activity with a large degree of heterogeneity that is informally or tacitly separated into classes. Yet, the precise number and properties of such classes are unclear. Do they exist on a continuum and, if so, when is it appropriate to divide that continuum into functional regions? In a large dataset of glutamatergic cortical connections, we perform model-based characterization to infer the number and characteristics of functionally distinct subtypes of synaptic dynamics. In rodent data, we find five clusters that partially converge with transgenic-associated subtypes. Strikingly, the application of the same clustering method in human data infers a highly similar number of clusters, supportive of stable clustering. This nuanced dictionary of functional subtypes shapes the heterogeneity of cortical synaptic dynamics and provides a lens into the basic motifs of information transmission in the brain.
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- 2024
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36. Effect of Age-Friendly Communities Action Plan on Trajectories of Older Canadians’ Depressive Symptoms Between 2018 and 2020: Multilevel Results From the Canadian Longitudinal Study on Aging
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Mélanie Levasseur PhD, Daniel Naud PhD, Verena Menec PhD, Marie-France Dubois PhD, Christina Wolfson PhD, Lauren E. Griffith PhD, Lise Trottier MSc, Jacqueline McMillan PhD, Mélissa Généreux MD, Mathieu Roy PhD, Yves Couturier PhD, and Parminder Raina PhD
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Public aspects of medicine ,RA1-1270 - Abstract
As the COVID-19 pandemic impacted mental health, this longitudinal study examined the effect of age-friendly communities (AFC) action plan on older adults’ depressive symptoms. Using the CLSA, the CLSA COVID-19 Questionnaire study, survey of Canadian municipalities, and the census, the depressive symptoms trajectories were modeled with multilevel multinomial regressions. Most respondents (66.1%) had non-depressed trajectories, 28.1% experienced a moderate increase in depressive symptoms, and 5.8% had a depressed trajectory. AFC action plans did not have a protective effect on these trajectories. Being a female, greater loneliness, lower income, ≥2 chronic conditions, inferior social participation, weaker sense of belonging, COVID-19 infection, and pandemic stressors predicted a depressed trajectory. Neighborhood’s deprivation had a weak protective effect on the declining trajectory. Although AFC action plans provided no benefits during the pandemic, volunteers facilitating resource access and social interactions could limit any increase in depressive symptoms.
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- 2024
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37. Highly transparent contacts to the 1D hole gas in ultra-scaled Ge/Si core/shell nanowires
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Sistani, Masiar, Delaforce, Jovian, Kramer, Roman, Roch, Nicolas, Luong, Minh Anh, Hertog, M. den, Robin, Eric, Smoliner, Jürgen, Yao, Jun, Lieber, Charles, Naud, Cécile, Lugstein, Alois, and Buisson, Olivier
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Materials Science - Abstract
Semiconductor-superconductor hybrid systems have outstanding potential for emerging high-performance nanoelectronics and quantum devices. However, critical to their successful application is the fabrication of high-quality and reproducible semiconductor-superconductor interfaces. Here, we realize and measure axial Al-Ge-Al nanowire heterostructures with atomically precise interfaces, enwrapped by an ultrathin epitaxial Si layer further denoted as Al-Ge/Si-Al nanowire heterostructures. The heterostructures were synthesized by a thermally induced exchange reaction of single-crystalline Ge/Si core/shell nanowires and lithographically defined Al contact pads. Applying this heterostructure formation scheme enables self-aligned quasi one-dimensional crystalline Al leads contacting ultrascaled Ge/Si segments with contact transparencies greater than 96%. Integration into back-gated field-effect devices and continuous scaling beyond lithographic limitations allows us to exploit the full potential of the highly transparent contacts to the 1D hole gas at the Ge-Si interface. This leads to the observation of ballistic transport as well as quantum confinement effects up to temperatures of 150 K. Low-temperature measurements reveal proximity-induced superconductivity in the Ge/Si core/shell nanowires. The realization of a Josephson field-effect transistor allows us to study the subgap structure caused by multiple Andreev reflections. Most importantly, the absence of a quantum dot regime indicates a hard superconducting gap originating from the highly transparent contacts to the 1D hole gas, which is potentially interesting for the study of Majorana zero modes. Moreover, underlining the importance of the proposed thermally induced Al-Ge/Si-Al heterostructure formation technique, our system could contribute to the development of key components of quantum computing such as gatemon or transmon qubits
- Published
- 2020
38. Composite Pressure Cell for Pulsed Magnets
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Sun, Dan, Naud, Martin F., Nguyen, Doan N, Betts, Jonathan B, Singleton, John, and Balakirev, Fedor F
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Condensed Matter - Strongly Correlated Electrons ,Physics - Applied Physics - Abstract
Extreme pressures and high magnetic fields can affect materials in profound and fascinating ways. However, large pressures and fields are often mutually incompatible; the rapidly changing fields provided by pulsed magnets induce eddy currents in the metallic components used in conventional pressure cells, causing serious heating, forces and vibration. Here we report a diamond-anvil-cell made mainly out of insulating composites that minimizes inductive heating while retaining sufficient strength to apply pressures of up to 9 GPa. Any residual metallic components are made of low-conductivity metals and patterned to reduce eddy currents. The simple design enables rapid sample or pressure changes, desired by pulsed-magnetic-field-facility users. The pressure cell has been used in pulsed magnetic fields of up to 65 T with no noticeable heating at cryogenic temperatures. Several measurement techniques are possible inside the cell at temperatures as low as 500 mK.
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- 2020
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39. Manifolds for Unsupervised Visual Anomaly Detection
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Naud, Louise and Lavin, Alexander
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning ,Statistics - Machine Learning - Abstract
Anomalies are by definition rare, thus labeled examples are very limited or nonexistent, and likely do not cover unforeseen scenarios. Unsupervised learning methods that don't necessarily encounter anomalies in training would be immensely useful. Generative vision models can be useful in this regard but do not sufficiently represent normal and abnormal data distributions. To this end, we propose constant curvature manifolds for embedding data distributions in unsupervised visual anomaly detection. Through theoretical and empirical explorations of manifold shapes, we develop a novel hyperspherical Variational Auto-Encoder (VAE) via stereographic projections with a gyroplane layer - a complete equivalent to the Poincar\'e VAE. This approach with manifold projections is beneficial in terms of model generalization and can yield more interpretable representations. We present state-of-the-art results on visual anomaly benchmarks in precision manufacturing and inspection, demonstrating real-world utility in industrial AI scenarios. We further demonstrate the approach on the challenging problem of histopathology: our unsupervised approach effectively detects cancerous brain tissue from noisy whole-slide images, learning a smooth, latent organization of tissue types that provides an interpretable decisions tool for medical professionals.
- Published
- 2020
40. A random cover of a compact hyperbolic surface has relative spectral gap $\frac{3}{16}-\varepsilon$
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Magee, Michael, Naud, Frédéric, and Puder, Doron
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Mathematics - Spectral Theory ,Mathematics - Analysis of PDEs ,Mathematics - Probability ,58J50, 05C80, 20P05, 11F72, 20C30, 20F65 - Abstract
Let $X$ be a compact connected hyperbolic surface, that is, a closed connected orientable smooth surface with a Riemannian metric of constant curvature -1. For each $n\in\mathbf{N}$, let $X_{n}$ be a random degree-$n$ cover of $X$ sampled uniformly from all degree-$n$ Riemannian covering spaces of $X$. An eigenvalue of $X$ or $X_{n}$ is an eigenvalue of the associated Laplacian operator $\Delta_{X}$ or $\Delta_{X_{n}}$. We say that an eigenvalue of $X_n$ is new if it occurs with greater multiplicity than in $X$. We prove that for any $\varepsilon>0$, with probability tending to 1 as $n\to\infty$, there are no new eigenvalues of $X_n$ below $\frac{3}{16}-\varepsilon$. We conjecture that the same result holds with $\frac{3}{16}$ replaced by $\frac{1}{4}$., Comment: 54 pages, 5 figures. Accepted for publication in GAFA. This version: journal version, incorporated referees' comments and added figures
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- 2020
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41. Dominant Cloud Controlling Factors for Low‐Level Cloud Fraction: Subtropical Versus Extratropical Oceans
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Catherine M. Naud, Gregory S. Elsaesser, and James F. Booth
- Subjects
cloud controlling factor ,low‐level clouds ,extratropics ,satellite observations ,stratocumulus regions ,western boundary currents ,Geophysics. Cosmic physics ,QC801-809 - Abstract
Abstract To improve cloud feedback understanding and simulation, observations have been used to quantify the rate of change of cloud radiative properties as a function of specific environmental metrics (or cloud controlling factors; CCFs). The study focuses on low‐level cloud dominated regions during 2006–2010. For each ocean gridpoint, Spearman's rank correlation coefficients of daily mean observed cloud fraction versus (a) 10‐m wind, (b) sensible heat flux (SHF), (c) sea surface temperature, (d) estimated inversion strength (EIS), (e) 850 hPa vertical velocity, and (f) the M parameter (∆θskin800hPa) are sorted to identify the dominant CCFs in both extratropics (30°–60°N/S) and subtropics (30°S–30°N). A novel map for visualizing dominant CCFs for low‐level cloud fraction reveals that: ∆θskin800hPa dominates in the subtropical stratocumulus regions while 10‐m winds dominate in shallow cumulus regions but in the extratropics, a different inversion structure diagnostic (EIS) dominates, while SHF dominates in western boundary current areas.
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- 2023
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42. Observation of quantum many-body effects due to zero point fluctuations in superconducting circuits
- Author
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Leger, Sebastien, Puertas-Martinez, Javier, Bharadwaj, Karthik, Dassonneville, Remy, Delaforce, Jovian, Foroughi, Farshad, Milchakov, Vladimir, Planat, Luca, Buisson, Olivier, Naud, Cecile, Hasch-Guichard, Wiebke, Florens, Serge, Snyman, Izak, and Roch, Nicolas
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics ,Quantum Physics - Abstract
Electromagnetic fields possess zero point fluctuations (ZPF) which lead to observable effects such as the Lamb shift and the Casimir effect. In the traditional quantum optics domain, these corrections remain perturbative due to the smallness of the fine structure constant. To provide a direct observation of non-perturbative effects driven by ZPF in an open quantum system we wire a highly non-linear Josephson junction to a high impedance transmission line, allowing large phase fluctuations across the junction. Consequently, the resonance of the former acquires a relative frequency shift that is orders of magnitude larger than for natural atoms. Detailed modelling confirms that this renormalization is non-linear and quantum. Remarkably, the junction transfers its non-linearity to about 30 environmental modes, a striking back-action effect that transcends the standard Caldeira-Leggett paradigm. This work opens many exciting prospects for longstanding quests such as the tailoring of many-body Hamiltonians in the strongly non-linear regime, the observation of Bloch oscillations, or the development of high-impedance qubits., Comment: 10 pages, 4 figures and Supplementary Material
- Published
- 2019
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43. Constraints on the occurrence and distribution of 1--20 \mj\ companions to stars at separations of 5--5000\,au from a compilation of direct imaging surveys
- Author
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Baron, Frédérique, Lafrenière, David, Artigau, Étienne, Gagné, Jonathan, Rameau, Julien, Delorme, Philippe, and Naud, Marie-Eve
- Subjects
Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We present the first statistical analysis of exoplanet direct imaging surveys combining adaptive optics imaging at small separations with deep seeing-limited observations at large separations allowing us to study the entire orbital separation domain from 5 to 5000~au simultaneously. Our sample of 344 stars includes only confirmed members of nearby young associations and is based on all AO direct-imaging detection limits readily available online, with addition of our own previous seeing limited surveys. Assuming that the companion distribution in mass and semi-major axis follows a power law distribution and adding a dependence on the mass of the host star, such as $d^2n\propto fM^{\alpha}a^{\beta} (M_\star/M_{\odot})^{\gamma}$d$ M $d$a$, we constrain the parameters to obtained $\alpha=-0.18^{+0.77}_{-0.65}$, $\beta=-1.43^{+0.23}_{-0.24}$, and $\gamma=0.62^{+0.56}_{-0.50}$,at a 68\% confidence level, and we obtain $f=0.11^{+0.11}_{-0.05}$, for the overall planet occurrence rate for companions with masses between 1 to 20~\mj\ in the range 5--5000~au. Thus, we find that occurrence of companions is negatively correlated with semi-major axis and companion mass (marginally) but is positively correlated with the stellar host mass. Our inferred mass distribution is in good agreement with other distributions found previously from direct imaging surveys for planets and brown dwarfs, but is shallower as a function of mass than the distributions inferred by radial velocity surveys of gas giants in the 1--3\,au range. This may suggest that planets at these wide and very-wide separations represent the low-mass tail of the brown dwarfs and stellar companion distribution rather than an extension of the distribution of the inner planets., Comment: 26 pages, 8 figures Accepted to Astronomical Journal Updated Table 4
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- 2019
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44. Fabrication and characterization of aluminum SQUID transmission lines
- Author
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Planat, Luca, Al-Tavil, Ekaterina, Martinez, Javier Puertas, Dassonneville, Remy, Foroughi, Farshad, Leger, Sebastien, Bharadwaj, Karthik, Delaforce, Jovian, Milchakov, Vladimir, Naud, Cecile, Buisson, Olivier, Hasch-Guichard, Wiebke, and Roch, Nicolas
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics ,Quantum Physics - Abstract
We report on the fabrication and characterization of 50 Ohms, flux-tunable, low-loss, SQUID-based transmission lines. The fabrication process relies on the deposition of a thin dielectric layer (few tens of nanometers) via Atomic Layer Deposition (ALD) on top of a SQUID array, the whole structure is then covered by a non-superconducting metallic top ground plane. We present experimental results from five different samples. We systematically characterize their microscopic parameters by measuring the propagating phase in these structures. We also investigate losses and discriminate conductor from dielectric losses. This fabrication method offers several advantages. First, the SQUID array fabrication does not rely on a Niobium tri-layer process but on a simpler double angle evaporation technique. Second, ALD provides high quality dielectric leading to low-loss devices. Further, the SQUID array fabrication is based on a standard, all-aluminum process, allowing direct integration with superconducting qubits. Moreover, our devices are in-situ flux tunable, allowing mitigation of incertitude inherent to any fabrication process. Finally, the unit cell being a single SQUID (no extra ground capacitance is needed), it is straightforward to modulate the size of the unit cell periodically, allowing band-engineering. This fabrication process can be directly applied to traveling wave parametric amplifiers., Comment: 9 pages, 9 figures, Appendixes
- Published
- 2019
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45. A photonic crystal Josephson traveling wave parametric amplifier
- Author
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Planat, Luca, Ranadive, Arpit, Dassonneville, Remy, Martinez, Javier Puertas, Leger, Sebastien, Naud, Cecile, Buisson, Olivier, Hasch-Guichard, Wiebke, Basko, Denis M., and Roch, Nicolas
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics ,Quantum Physics - Abstract
An amplifier combining noise performances as close as possible to the quantum limit with large bandwidth and high saturation power is highly desirable for many solid state quantum technologies such as high fidelity qubit readout or high sensitivity electron spin resonance for example. Here we introduce a new Traveling Wave Parametric Amplifier based on Superconducting QUantum Interference Devices. It displays a 3 GHz bandwidth, a -102 dBm 1-dB compression point and added noise near the quantum limit. Compared to previous state-of-the-art, it is an order of magnitude more compact, its characteristic impedance is in-situ tunable and its fabrication process requires only two lithography steps. The key is the engineering of a gap in the dispersion relation of the transmission line. This is obtained using a periodic modulation of the SQUID size, similarly to what is done with photonic crystals. Moreover, we provide a new theoretical treatment to describe the non-trivial interplay between non-linearity and such periodicity. Our approach provides a path to co-integration with other quantum devices such as qubits given the low footprint and easy fabrication of our amplifier., Comment: 6 pages, 4 figures, Appendixes
- Published
- 2019
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46. Explicit spectral gaps for random covers of Riemann surfaces
- Author
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Magee, Michael and Naud, Frédéric
- Subjects
Mathematics - Spectral Theory ,Mathematics - Analysis of PDEs ,Mathematics - Probability ,58J50, 35B34, 05C80, 05C50 - Abstract
We introduce a permutation model for random degree $n$ covers $X_{n}$ of a non-elementary convex-cocompact hyperbolic surface $X=\Gamma\backslash\mathbb{H}$. Let $\delta$ be the Hausdorff dimension of the limit set of $\Gamma$. We say that a resonance of $X_{n}$ is new if it is not a resonance of $X$, and similarly define new eigenvalues of the Laplacian. We prove that for any $\epsilon>0$ and $H>0$, with probability tending to $1$ as $n\to\infty$, there are no new resonances $s=\sigma+it$ of $X_{n}$ with $\sigma\in[\frac{3}{4}\delta+\epsilon,\delta]$ and $t\in[-H,H]$. This implies in the case of $\delta>\frac{1}{2}$ that there is an explicit interval where there are no new eigenvalues of the Laplacian on $X_{n}$. By combining these results with a deterministic `high frequency' resonance-free strip result, we obtain the corollary that there is an $\eta=\eta(X)$ such that with probability $\to1$ as $n\to\infty$, there are no new resonances of $X_{n}$ in the region $\{\,s\,:\,\mathrm{Re}(s)>\delta-\eta\,\}$., Comment: 38 pages, 2 figures. Final revisions based on referee comments: minor corrections and simplification of Section 5
- Published
- 2019
47. Fast high fidelity quantum non-demolition qubit readout via a non-perturbative cross-Kerr coupling
- Author
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Dassonneville, R., Ramos, T., Milchakov, V., Planat, L., Dumur, É., Foroughi, F., Puertas, J., Leger, S., Bharadwaj, K., Delaforce, J., Naud, C., Hasch-Guichard, W., García-Ripoll, J. J., Roch, N., and Buisson, O.
- Subjects
Quantum Physics - Abstract
Qubit readout is an indispensable element of any quantum information processor. In this work, we experimentally demonstrate a non-perturbative cross-Kerr coupling between a transmon and a polariton mode which enables an improved quantum non-demolition (QND) readout for superconducting qubits. The new mechanism uses the same experimental techniques as the standard QND qubit readout in the dispersive approximation, but due to its non-perturbative nature, it maximizes the speed, the single-shot fidelity and the QND properties of the readout. In addition, it minimizes the effect of unwanted decay channels such as the Purcell effect. We observed a single-shot readout fidelity of 97.4% for short 50 ns pulses, and we quantified a QND-ness of 99% for long measurement pulses with repeated single-shot readouts.
- Published
- 2019
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48. Kleinian Schottky groups, Patterson-Sullivan measures and Fourier decay
- Author
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Li, Jialun, Naud, Frederic, and Pan, Wenyu
- Subjects
Mathematics - Dynamical Systems ,37D40, 42B10, 60B15 - Abstract
Let $\Gamma$ be a Zariski dense Kleinian Schottky subgroup of PSL2(C). Let $\Lambda(\Gamma)$ be its limit set, endowed with a Patterson-Sullivan measure $\mu$ supported on $\Lambda(\Gamma)$. We show that the Fourier transform $\widehat{\mu}(\xi)$ enjoys polynomial decay as $\vert \xi \vert$ goes to infinity. This is a PSL2(C) version of the result of Bourgain-Dyatlov [8], and uses the decay of exponential sums based on Bourgain-Gamburd sum-product estimate on C. These bounds on exponential sums require a delicate non-concentration hypothesis which is proved using some representation theory and regularity estimates for stationary measures of certain random walks on linear groups., Comment: 2 figures
- Published
- 2019
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49. Expert consultation using the on-line Delphi method for the revision of syndromic groups compiled from emergency data (SOS Médecins and OSCOUR®) in France
- Author
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Marie-Michèle Thiam, Leslie Simac, Erica Fougère, Cécile Forgeot, Laure Meurice, Jérôme Naud, Yann Le Strat, and Céline Caserio-Schönemann
- Subjects
Delphi ,Syndromic group ,Expert consensus ,Syndromic surveillance ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Consultation data from emergency general practitioners known as SOS Médecins and emergency departments (ED) from OSCOUR® network to the French syndromic surveillance system SurSaUD® (Surveillance sanitaire des urgences et décès). These data are aggregated and monitored on a daily basis through groupings of one or more medical symptoms or diagnoses (“syndromic groups” (SG)). The objective of this study was to evaluate, revise and enrich the composition of SGs through a consensus of experts who contributed or have experience in syndromic surveillance. Methods Three rounds of a Delphi survey were organised, involving 15 volunteers from SOS Médecins and 64 ED physicians in the OSCOUR® network as well as 8 international epidemiologists. Thirty-four SOS Médecins and 40 OSCOUR® SGs covering major medical specialities were put to the experts, along with their diagnostic codes and their surveillance objectives. In each round, the experts could retain or reject the codes according to the surveillance objective. The panel could also put forward new diagnostic codes in the 1st round, included in subsequent rounds. Consensus was reached for a code if 80% of participants had chosen to keep it, or less than 20% to reject it. Results A total of 12 SOS Médecins doctors (80%), 30 ED doctors (47%) and 4 international experts (50%) participated in the three rounds. All of the SGs presented to the panel included 102 initial diagnostic codes and 73 additional codes for SOS Médecins, 272 initial diagnostic codes and 204 additional codes for OSCOUR®. At the end of the 3 rounds, 14 SOS Médecins (40%) and 11 OSCOUR® (28%) SGs achieved a consensus to maintain all of their diagnostic codes. Among these, indicators of winter seasonal surveillance (bronchiolitis and gastroenteritis) were included. Conclusion This study involved a panel of national experts with international representation and a good level of involvement throughout the survey. In the absence of a standard definition, the Delphi method has been shown to be useful in defining and validating syndromic surveillance indicators.
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- 2022
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50. Impact of targeted pulmonary arterial hypertension therapies in severe pulmonary hypertension in chronic lung diseases
- Author
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Romain Naud, Julien Bermudez, Noémie Resseguier, Ana Nieves, Bérengère Coltey, Nadine Dufeu, Clarisse Gautier, Youssef Trigui, Marc Laine, Benjamin Coiffard, and Martine Reynaud-Gaubert
- Subjects
Medicine - Abstract
Research questions Patients with severe pulmonary hypertension associated with chronic lung disease have a poor prognosis. Targeted pulmonary arterial hypertension therapies might improve exercise capacity and outcome, but there are no guidelines on treatments which are not recommended because of an unproven benefit, with discordant results from few studies in this context. The aim of our study was to evaluate targeted pulmonary arterial hypertension therapies for severe group 3 pulmonary hypertension patients. Study design and methods We conducted an observational retrospective monocentre study on patients with severe group 3 pulmonary hypertension diagnosed on right heart catheterisation treated with targeted therapies. Primary outcome was an improvement of the distance on 6-min walk test of ≥30 m. Secondary end-points included changes in haemodynamics (pulmonary vascular resistance (PVR) and mean pulmonary arterial pressure (mPAP)) and identification of potential predictive factors of therapeutic response. Results 139 patients were enrolled. Most patients had monotherapy with phosphodiesterase 5 inhibitors (n=128; 92%). Mean change in 6-min walk distance was +1.5 m after treatment (p=0.59). Forced expiratory volume in 1 s and forced vital capacity were not predictive factors for response. We found a significant improvement of PVR and mPAP of −1.0 Wood Units (p
- Published
- 2023
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