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10. Hospitalisations and Deaths Averted by COVID-19 Vaccination in Navarre, Spain, 2021–2022

Author

Martínez-Baz, Iván, primary, Trobajo-Sanmartín, Camino, additional, Miqueleiz, Ana, additional, Egüés, Nerea, additional, García Cenoz, Manuel, additional, Casado, Itziar, additional, Navascués, Ana, additional, Fernández-Huerta, Miguel, additional, Echeverría, Aitziber, additional, Guevara, Marcela, additional, Ezpeleta, Carmen, additional, and Castilla, Jesús, additional

Published
2024
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11. Assessing variability in compliance with recommendations given by the International Diabetes Federation (IDF) for patients with type 2 diabetes in primary care using electronic records. The APNA study

Author

Brugos-Larumbe, Antonio, Aldaz-Herce, Pablo, Guillen-Grima, Francisco, Garjón-Parra, Francisco Javier, Bartolomé-Resano, Francisco Javier, Arizaleta-Beloqui, María Teresa, Pérez-Ciordia, Ignacio, Fernández-Navascués, Ana María, Lerena-Rivas, María José, Berjón-Reyero, Jesús, Jusué-Rípodas, Luisa, and Aguinaga-Ontoso, Ines

Published
2018
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12. Effectiveness of Nirsevimab Immunoprophylaxis Administered at Birth to Prevent Infant Hospitalisation for Respiratory Syncytial Virus Infection: A Population-Based Cohort Study.

Author

Ezpeleta, Guillermo, Navascués, Ana, Viguria, Natividad, Herranz-Aguirre, Mercedes, Juan Belloc, Sergio Enrique, Gimeno Ballester, Juan, Muruzábal, Juan Carlos, García-Cenoz, Manuel, Trobajo-Sanmartín, Camino, Echeverria, Aitziber, Martínez-Baz, Iván, Vera-Punzano, Noelia, Casado, Itziar, López-Mendoza, Héctor, Ezpeleta, Carmen, and Castilla, Jesús

Subjects
RESPIRATORY syncytial virus infections, COHORT analysis, IMMUNIZATION of children, HOSPITAL care, RESPIRATORY syncytial virus
Abstract

Respiratory syncytial virus (RSV) infection is a frequent cause of hospitalisation in the first few months of life; however, this risk rapidly decreases with age. Nirsevimab immunoprophylaxis was approved in the European Union for the prevention of RSV-associated lower respiratory tract disease in infants during their first RSV season. We evaluated the effectiveness of nirsevimab in preventing hospitalisations for confirmed RSV infection and the impact of a strategy of immunisation at birth. A population-based cohort study was performed in Navarre, Spain, where nirsevimab was offered at birth to all children born from October to December 2023. Cox regression was used to estimate the hazard ratio of hospitalisation for PCR-confirmed RSV infection between infants who received and did not receive nirsevimab. Of 1177 infants studied, 1083 (92.0%) received nirsevimab. The risk of hospitalisation for RSV was 8.5% (8/94) among non-immunised infants versus 0.7% (8/1083) in those that were immunised. The estimated effectiveness of nirsevimab was 88.7% (95% confidence interval, 69.6–95.8). Immunisation at birth of infants born between October and December 2023 prevented one hospitalisation for every 15.3 immunised infants. Immunisation of children born from September to January might prevent 77.5% of preventable hospitalisations for RSV in infants born in 2023–2024. These results support the recommendation of nirsevimab immunisation at birth to children born during the RSV epidemic or in the months immediately before to prevent severe RSV infections and alleviate the overload of paediatric hospital resources. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Seroprevalence of antibodies against SARS-CoV-2 and risk of COVID-19 in Navarre, Spain, May to July 2022

Author

Castilla, Jesús, primary, Lecea, Óscar, additional, Martín Salas, Carmen, additional, Quílez, Delia, additional, Miqueleiz, Ana, additional, Trobajo-Sanmartín, Camino, additional, Navascués, Ana, additional, Martínez-Baz, Iván, additional, Casado, Itziar, additional, Burgui, Cristina, additional, Egüés, Nerea, additional, Ezpeleta, Guillermo, additional, and Ezpeleta, Carmen, additional

Published
2022
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21. Independent Role of Severe Obesity as a Risk Factor for COVID‐19 Hospitalization: A Spanish Population‐Based Cohort Study

Author

Fresán, Ujué, Guevara, Marcela, Elía, Fernando, Albéniz, Esther, Burgui, Cristina, Castilla, Jesús, Martín, Carmen, Navascués, Ana, Portillo, María Eugenia, Polo, Isabel, Ezpeleta, Carmen, Gorricho, Javier, Ardanaz, Eva, Ascunce, Nieves, Arriazu, Maite, Barricarte, Aurelio, Barriuso, Laura, Casado, Itziar, Díaz, Jorge, Ederra, María, Egüés, Nerea, Garde, Carmen, Gómez‐Ibáñez, Carlos, García Cenoz, Manuel, García, Vega, Iriarte, Nerea, Martínez‐Baz, Iván, Moreno‐Iribas, Conchi, Sayón, Carmen, and Vidán, Juana

Subjects
Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Population, Medicine (miscellaneous), 030209 endocrinology & metabolism, Body Mass Index, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, Endocrinology, Risk Factors, Internal medicine, medicine, Humans, Prospective Studies, 030212 general & internal medicine, Poisson regression, Risk factor, Prospective cohort study, education, Pandemics, Aged, education.field_of_study, Nutrition and Dietetics, SARS-CoV-2, business.industry, Incidence, Incidence (epidemiology), COVID-19, Middle Aged, Obesity, Morbid, 3. Good health, Hospitalization, Intensive Care Units, Spain, Relative risk, Cohort, symbols, Female, business, Cohort study
Abstract

Objectives This study analyzed the association between severe obesity and coronavirus disease 2019 (COVID-19) hospitalization and severe disease. Methods The incidence of hospitalization for laboratory-confirmed COVID-19 was evaluated in a prospective population-based cohort of 433,995 persons aged 25 to 79 years in Spain during March and April of 2020. Persons with and without class 3 obesity were compared using Poisson regression to estimate the adjusted relative risk (aRR) from class 3 obesity of COVID-19 hospitalization and of severe disease (intensive care unit admission or death). Differences in the effect by age, sex, and chronic conditions were evaluated. Results Individuals with class 3 obesity had a higher risk of hospitalization (aRR = 2.20, 95% CI: 1.66-2.93) and developing severe COVID-19 (aRR = 2.30, 95% CI: 1.20-4.40). In people younger than 50 years, these effects were more pronounced (aRR = 5.02, 95% CI: 3.19-7.90 and aRR = 13.80, 95% CI: 3.11-61.17, respectively), whereas no significant effects were observed in those aged 65 to 79 years (aRR = 1.22, 95% CI: 0.70-2.12 and aRR = 1.42, 95% CI: 0.52-3.88, respectively). Sex and chronic conditions did not modify the effect of class 3 obesity in any of the outcomes. Conclusions Severe obesity is a relevant risk factor for COVID-19 hospitalization and severity in young adults, having a magnitude similar to that of aging. Tackling the current obesity pandemic could alleviate the impact of chronic and infectious diseases.

Published
2020
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23. Effectiveness of influenza vaccination in preventing influenza in primary care, Navarre, Spain, 2021/22

Author

Martínez-Baz, Iván, primary, Casado, Itziar, additional, Miqueleiz, Ana, additional, Navascués, Ana, additional, Pozo, Francisco, additional, Trobajo-Sanmartín, Camino, additional, Albéniz, Esther, additional, Elía, Fernando, additional, Burgui, Cristina, additional, Fernández-Huerta, Miguel, additional, Ezpeleta, Carmen, additional, and Castilla, Jesús, additional

Published
2022
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26. Vaccine effectiveness against symptomatic SARS-CoV-2 infection in adults aged 65 years and older in primary care : I-MOVE-COVID-19 project, Europe, December 2020 to May 2021

Author

Kissling, Esther, Hooiveld, Mariette, Sandonis Martín, Virginia, Martínez-Baz, Iván, William, Naoma, Vilcu, Ana-Maria, Mazagatos, Clara, Domegan, Lisa, de Lusignan, Simon, Meijer, Adam, Machado, Ausenda, Brytting, Mia, Casado, Itziar, Murray, Josephine-L K., Belhillil, Sylvie, Larrauri, Amparo, O’Donnell, Joan, Tsang, Ruby, de Lange, Marit, Rodrigues, Ana Paula, Riess, Maximilian, Castilla, Jesús, Hamilton, Mark, Falchi, Alessandra, Pozo, Francisco, Dunford, Linda, Cogdale, Jade, Jansen, Tessa, Guiomar, Raquel, Enkirch, Theresa, Burgui, Cristina, Sigerson, Debbie, Blanchon, Thierry, Martínez Ochoa, Eva María, Connell, Jeff, Ellis, Joanna, van Gageldonk-Lafeber, Rianne, Kislaya, Irina, Rose, Angela MC, Valenciano, Marta, Andrews, Nick, Lopez Bernal, Jamie, Whitaker, Heather, Guerrisi, Caroline, Launay, Titouan, Masse, Shirley, van der Werf, Sylvie, Enouf, Vincent, Cuddihy, John, McKenna, Adele, Joyce, Michael, de Gascun, Cillian, Moran, Joanne, Miqueleiz, Ana, Navascués, Ana, Trobajo-Sanmartín, Camino, Ezpeleta, Carmen, Moreno, Paula López, Gorricho, Javier, Ardanaz, Eva, Baigorria, Fernando, Barricarte, Aurelio, de la Cruz, Enrique, Egüés, Nerea, García Cenoz, Manuel, Guevara, Marcela, Moreno-Iribas, Conchi, Sayón, Carmen, Gomez, Verónica, Nunes, Baltazar, Roquete, Rita, Silva, Adriana, Melo, Aryse, Costa, Inês, Verdasca, Nuno, Conde, Patrícia, Marques, Diogo FP, Molesworth, Anna, Quinn, Leanne, Leyton, Miranda, Campbell, Selin, Thoulass, Janine, McMenamin, Jim, Mateo, Ana Martínez, Basile, Luca, Castrillejo, Daniel, Quiñones Rubio, Carmen, Delgado-Sanz, Concepción, Oliva., Jesús, University of St Andrews. School of Medicine, team, I-MOVE-COVID-19 primary care study, above), I-MOVE-COVID-19 primary care study team (in addition to authors, EpiConcept [Paris], Netherlands Institute for Health Services Research [Utrecht] (NIVEL), Instituto de Salud Carlos III [Madrid] (ISC), Navarra Institute for Health Research / Instituto de Investigación Sanitaria de Navarra (IdiSNA), Universidad Pública de Navarra [Espagne] = Public University of Navarra (UPNA)-Universidad de Navarra [Pamplona] (UNAV)-Clínica Universidad de Navarra [Pamplona], CIBER de Epidemiología y Salud Pública (CIBERESP), Public Health Scotland [Glasgow], Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Health Service Executive [Dublin] (HSE), University of Oxford, National Institute for Public Health and the Environment [Bilthoven] (RIVM), Instituto Nacional de Saùde Dr Ricardo Jorge [Portugal] (INSA), Public Health Agency of Sweden, Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses (GMV-ARN (UMR_3569 / U-Pasteur_2)), Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Centre National de Référence des virus des infections respiratoires (dont la grippe) - National Reference Center Virus Influenzae [Paris] (CNR - laboratoire coordonnateur), Institut Pasteur [Paris] (IP), Università di Corsica Pasquale Paoli [Université de Corse Pascal Paoli], Partenaires INRAE, Institut National de la Santé et de la Recherche Médicale (INSERM), University College Dublin [Dublin] (UCD), Public Health England [London], Dirección General de Salud Pública, This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101003673., European Project: 101003673,H2020-SC1-PHE-CORONAVIRUS-2020,I-MOVE-COVID-19(2020), and Unión Europea. Comisión Europea. H2020

Subjects
Infecções Respiratórias, Adult, Test-negative design, 2019-20 coronavirus outbreak, Pediatrics, medicine.medical_specialty, RM, COVID-19 Vaccines, Coronavirus disease 2019 (COVID-19), Epidemiology, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), [SDV]Life Sciences [q-bio], Primary health care, Primary care, 030204 cardiovascular system & hematology, Multicentre study, 03 medical and health sciences, Elderly, 0302 clinical medicine, SDG 3 - Good Health and Well-being, RA0421, RA0421 Public health. Hygiene. Preventive Medicine, Virology, Medicine, Humans, 030212 general & internal medicine, Aged, Vaccine effectiveness, QR355, vaccine effectiveness, Primary Health Care, business.industry, SARS-CoV-2, Efetividade da vacina contra COVID-19, test-negative design, Public Health, Environmental and Occupational Health, COVID-19, 3rd-DAS, NIS, Estados de Saúde e de Doença, multicentre study, 3. Good health, RM Therapeutics. Pharmacology, Vaccination, Europe, Determinantes da Saúde e da Doença, business, QR355 Virology, Rapid Communication
Abstract

I-MOVE-COVID-19 primary care study team (in addition to authors above): Nick Andrews, Jamie Lopez Bernal, Heather Whitaker, Caroline Guerrisi, Titouan Launay, Shirley Masse, Sylvie van der Werf, Vincent Enouf, John Cuddihy, Adele McKenna, Michael Joyce, Cillian de Gascun, Joanne Moran, Ana Miqueleiz, Ana Navascués, Camino Trobajo-Sanmartín, Carmen Ezpeleta, Paula López Moreno, Javier Gorricho, Eva Ardanaz, Fernando Baigorria, Aurelio Barricarte, Enrique de la Cruz, Nerea Egüés, Manuel García Cenoz, Marcela Guevara, Conchi Moreno-Iribas, Carmen Sayón, Verónica Gomez, Baltazar Nunes, Rita Roquete, Adriana Silva, Aryse Melo, Inês Costa, Nuno Verdasca, Patrícia Conde, Diogo FP Marques, Anna Molesworth, Leanne Quinn, Miranda Leyton, Selin Campbell, Janine Thoulass, Jim McMenamin, Ana Martínez Mateo, Luca Basile, Daniel Castrillejo, Carmen Quiñones Rubio, Concepción Delgado-Sanz, Jesús Oliva. The I-MOVE-COVID-19 network collates epidemiological and clinical information on patients with coronavirus disease (COVID-19), including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virological characterisation in 11 European countries [1]. One component of I-MOVE-COVID-19 is the multicentre vaccine effectiveness (VE) study at primary care/outpatient level in nine European study sites in eight countries. We measured overall and product-specific COVID-19 VE against symptomatic SARS-CoV-2 infection among those aged 65 years and older. We also measured VE by time since vaccination. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101003673. info:eu-repo/semantics/publishedVersion

Published
2021
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27. Risk Factors of Infection, Hospitalization and Death from SARS-CoV-2: A Population-Based Cohort Study

Author

Castilla, Jesús, Guevara, Marcela, Miqueleiz, Ana, Baigorria, Fernando, Ibero-Esparza, Carlos, Navascués, Ana, Trobajo-Sanmartín, Camino, Martínez-Baz, Iván, Casado, Itziar, Burgui, Cristina, Ezpeleta, Carmen, and Navarra, The Working Group for the Study of COVID-19 in Navarra The Working Group for the Study of COVID-19 in

Subjects
medicine.medical_specialty, inequality, Population, Disease, 030204 cardiovascular system & hematology, Article, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Epidemiology, medicine, cohort study, Dementia, 030212 general & internal medicine, Risk factor, education, education.field_of_study, business.industry, SARS-CoV-2 infection, COVID-19, General Medicine, COVID-19 severity, medicine.disease, mortality, 3. Good health, risk factor, Spain, Emergency medicine, Medicine, epidemiology, business, COVID-19 hospitalization, Cohort study, Kidney disease
Abstract

We conducted a prospective population-based cohort study to assess risk factors for infection, hospitalization, and death from SARS-CoV-2. The study comprised the people covered by the Health Service of Navarre, Spain. Sociodemographic variables and chronic conditions were obtained from electronic healthcare databases. Confirmed infections, hospitalizations, and deaths from SARS-CoV-2 were obtained from the enhanced epidemiological surveillance during the second SARS-CoV-2 epidemic surge (July–December 2020), in which diagnostic tests were widely available. Among 643,757 people, 5497 confirmed infections, 323 hospitalizations, 38 intensive care unit admissions, and 72 deaths from SARS-CoV-2 per 100,000 inhabitants were observed. A higher incidence of confirmed infection was associated with people aged 15–29 years, nursing home residents, healthcare workers, people born in Latin America or Africa, as well as in those diagnosed with diabetes, cardiovascular disease, chronic obstructive pulmonary disease (COPD), chronic kidney disease, dementia, severe obesity, hypertension and functional dependence. The risk of hospitalization in the population was associated with males, higher age, nursing home residents, Latin American or African origin, and those diagnosed with immunodeficiency, diabetes, cardiovascular disease, COPD, asthma, kidney disease, cerebrovascular disease, cirrhosis, dementia, severe obesity, hypertension and functional dependence. The risk of death was associated with males, higher age, nursing home residents, Latin American origin, low income level, immunodeficiency, diabetes, cardiovascular disease, COPD, kidney disease, dementia, and functional dependence. This study supports the prioritization of the older population, nursing home residents, and people with chronic conditions and functional dependence for SARS-CoV-2 prevention and vaccination, and highlights the need for additional preventive support for immigrants.

Published
2021

28. Incidence and severity of pertussis hospitalisations in infants aged less than 1 year in 37 hospitals of six EU/EEA countries, results of PERTINENT sentinel pilot surveillance system, December 2015 to December 2018

Author

Merdrignac, Lore, Aït El Belghiti, Fatima, Pandolfi, Elisabetta, Jané, Mireia, Murphy, Jane, Fabiánová, Kateřina, García Cenoz, Manuel, Flem, Elmira, Guillot, Sophie, Tozzi, Alberto E, Carmona, Gloria, Habington, Adele, Zavadilová, Jana, Navasués, Ana, Bøås, Håkon, Lévy-Brühl, Daniel, Ferretti, Beatrice, Lanaspa, Miguel, O’Sullivan, Niam, Křížová, Pavla, Fernandino, Leticia, Bekkevold, Terese, Hanslik, Thomas, Muñoz-Almagro, Carmen, Bacci, Sabrina, Spiteri, Gianfranco, Valenciano, Marta, Moren, Alain, Savulescu, Camelia, Blechová, Zuzana, Bláhová, Květa, Kosina, Pavel, Sýkora, Josef, Holčíková, Alena, Širůček, Petr, Grembombo, Adèle, Brisse, Sylvain, Toubiana, Julie, Cotter, Suzanne, Cunney, Robert, O’Shaughnessy, Norma, O’Sullivan, Niamh, Rizzo, Caterina, Russo, Luisa, Campagna, Ilaria, Gesualdo, Francesco, Ciampini, Sara, Annarosa Ferro, Valentina, Boccuzzi, Elena, Vazquez Fernandez, Liliana, Esteva, Cristina, Lanaspa Perez, Miguel, Acosta, Lesly, Jordan Garcia, Yolanda, Navascués, Ana, Fernandino Zubieta, Leticia, Castilla, Jesús, EpiConcept [Paris], Direction des maladies infectieuses - Infectious Diseases Division [Saint-Maurice], Santé publique France - French National Public Health Agency [Saint-Maurice, France], IRCCS Ospedale Pediatrico Bambino Gesù [Roma], Public Health Agency of Catalonia [Barcelona, Spain] (PHAC), Temple Street Children's University Hospital [Dublin], National Institute of Public Health [Prague], Instituto de Investigación Sanitaria de Navarra [Pamplona, Spain] (IdiSNA), Norwegian Institute of Public Health [Oslo] (NIPH), Biodiversité et Epidémiologie des Bactéries pathogènes - Biodiversity and Epidemiology of Bacterial Pathogens, Institut Pasteur [Paris] (IP), Our Lady's Children's Hospital Crumlin (OLCHC), Complejo Hospitalario de Navarra, Institut de Recerca Pediàtrica Hospital Sant Joan de Déu [Barcelona, Spain], Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Universitat Internacional de Catalunya, CIBER de Epidemiología y Salud Pública (CIBERESP), European Centre for Disease Prevention and Control [Stockholm, Sweden] (ECDC), The European Centre for Disease Prevention and Control (ECDC) funded the PERTINENT study (Framework contract n° ECDC/2015/017)., PERTINENT group : Epiconcept, France: Lore Merdrignac, Epiconcept, Camelia Savulescu, Epiconcept, Marta Valenciano, Epiconcept, Alain Moren, Epiconcept. Czech Republic: Pavla Křížová, National Institute of Public Health, Prague, Kateřina Fabiánová, National Institute of Public Health, Prague, Jana Zavadilová, National Institute of Public Health, Prague, Zuzana Blechová, University Hospital Na Bulovce, Prague, Květa Bláhová, University Hospital Motol, Prague, Pavel Kosina, University Hospital, Hradec Králové, Josef Sýkora, University Hospital, Pilsen, Alena Holčíková, University Hospital, Brno, Petr Širůček, University Hospital, Ostrava. France: Daniel Lévy-Brühl, Santé Publique France, Saint-Maurice, Fatima Aït El Belghiti, Santé Publique France, Saint-Maurice, Adèle Grembombo, Santé Publique France, Saint-Maurice, Sophie Guillot, Institut Pasteur, Paris, Sylvain Brisse, Institut Pasteur, Paris, Julie Toubiana, Institut Pasteur, Paris. Ireland: Suzanne Cotter, HSE-Health Protection Surveillance Centre, Dublin, Jane Murphy, Temple Street Children’s University Hospital, Dublin, Robert Cunney, Temple Street Children’s University Hospital, Dublin, Norma O’Shaughnessy, Temple Street Children’s University Hospital, Dublin, Adele Habington, Our Lady’s Children’s hospital Crumlin, Dublin, Niamh O’Sullivan, Our Lady’s Children’s hospital Crumlin, Dublin. Italy: Elisabetta Pandolfi, Bambino Gesù Children Hospital, Rome, Alberto E Tozzi, Bambino Gesù Children Hospital, Rome, Caterina Rizzo, Bambino Gesù Children Hospital, Rome, Luisa Russo, Bambino Gesù Children Hospital, Rome, Ilaria Campagna, Bambino Gesù Children Hospital, Rome, Francesco Gesualdo, Bambino Gesù Children Hospital, Rome, Sara Ciampini, Bambino Gesù Children Hospital, Rome, Valentina Annarosa Ferro, Bambino Gesù Children Hospital, Rome, Elena Boccuzzi, Bambino Gesù Children Hospital, Rome. Norway: Elmira Flem, Norwegian Institute of Public Health, Oslo, Håkon Bøås, Norwegian Institute of Public Health, Oslo, Terese Bekkevold, Norwegian Institute of Public Health, Oslo, Liliana Vazquez Fernandez, Norwegian Institute of Public Health, Oslo. Catalonia, Spain: Carmen Muñoz-Almagro, Instituto de Recerca Pediatrica Hospital Sant Joan de Deu, Barcelona, Universitat Internacional de Catalunya and CIBER of Epidemiology and Public Health CIBERESP, Cristina Esteva, Instituto de Recerca Pediatrica Hospital Sant Joan de Deu, Barcelona, CIBER of Epidemiology and Public Health CIBERESP, Miguel Lanaspa Perez, Instituto de Recerca Pediatrica Hospital Sant Joan de Deu, Barcelona, Mireia Jané, Public Health Agency of Catalonia, Barcelona, University of Barcelona, Gloria Carmona, Public Health Agency of Catalonia, Barcelona, Lesly Acosta, Universitat Politècnica de Catalunya - BarcelonaTech (UPC), Public Health Agency of Catalonia, Barcelona, Yolanda Jordan Garcia, Instituto de Recerca Pediatrica Hospital Sant Joan de Deu, Barcelona, CIBER of Epidemiology and Public Health CIBERESP. Navarra, Spain: Manuel García Cenoz, Instituto de Salud Pública de Navarra, IdiSNA – Navarre Institute for Health Research, Pamplona, Ana Navascués, Complejo Hospitalario de Navarra, Pamplona, Leticia Fernandino Zubieta, Instituto de Salud Pública de Navarra, IdiSNA – Navarre Institute for Health Research, Pamplona, Jesús Castilla, Instituto de Salud Pública de Navarra, IdiSNA - Navarre Institute for Health Research, Pamplona. Sentinelles, France: Thomas Hanslik, Sorbonne Université, INSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique (IPLESP UMRS 1136), Paris. ECDC: Sabrina Bacci, European Centre for Disease Prevention and Control, Stockholm, Sweden, Gianfranco Spiteri, European Centre for Disease Prevention and Control, Stockholm, Sweden., Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. ADBD - Anàlisi de Dades Complexes per a les Decisions Empresarials, Brisse, Sylvain, European Centre for Disease Prevention and Control (ECDC), and Institut Pasteur [Paris]

Subjects
Male, 0301 basic medicine, Bordetella pertussis, Pediatrics, Whooping Cough, Epidemiology, Infants -- Salut i Higiene, Hospitals - Admission and discharge, Children -- Health and hygiene, Infants (Newborn), 0302 clinical medicine, Interquartile range, pertussis incidence, 030212 general & internal medicine, Vacunació, Czech Republic, media_common, Pertussis Vaccine, Babies, Surveillance, biology, Norway, Incidence, Incidence (epidemiology), pertussis, Vaccination, Gestational age, Hospitals -- Ingressos i altes, Hospitals, 3. Good health, Europe, Hospitalization, Italy, Nodrissons, hospital surveillance, France, Niños -- Salud e higiene, medicine.medical_specialty, 030106 microbiology, Hospitales -- Admisión y alta, 03 medical and health sciences, Virology, Intensive care, medicine, Humans, media_common.cataloged_instance, Tos ferina, European Union, European union, Disease burden, Aged, Whooping cough, business.industry, Infants nadons -- Malalties, active surveillance, Infant, Newborn, Public Health, Environmental and Occupational Health, Vacunación, Infant, biology.organism_classification, Tosferina, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Lactantes, business, Ireland, Ciències de la salut [Àrees temàtiques de la UPC]
Abstract

Introduction PERTINENT is a pilot active surveillance system of infants hospitalised with pertussis in six European Union/European Economic Area countries (37 hospitals, seven sites). Aim This observational study aimed to estimate annual pertussis incidence per site from 2016 to 2018 and respective trends between 2017 and 2018. Pertussis cases were described, including their severity. Methods We developed a generic protocol and laboratory guidelines to harmonise practices across sites. Cases were hospitalised infants testing positive for Bordetella pertussis by PCR or culture. Sites collected demographic, clinical, laboratory data, vaccination status, and risk/protective factors. We estimated sites’ annual incidences by dividing case numbers by the catchment populations. Results From December 2015 to December 2018, we identified 469 cases (247 males; 53%). The median age, birthweight and gestational age were 2.5 months (range: 0–11.6; interquartile range (IQR): 2.5), 3,280 g (range: 700–4,925; IQR: 720) and 39 weeks (range: 25–42; IQR: 2), respectively. Thirty cases (6%) had atypical presentation either with cough or cyanosis only or with absence of pertussis-like symptoms. Of 330 cases with information, 83 (25%) were admitted to intensive care units including five deceased infants too young to be vaccinated. Incidence rate ratios between 2018 and 2017 were 1.43 in Czech Republic (p = 0.468), 0.25 in Catalonia (p = 0.002), 0.71 in France (p = 0.034), 0.14 in Ireland (p = 0.002), 0.63 in Italy (p = 0.053), 0.21 in Navarra (p = 0.148) and zero in Norway. Conclusions Incidence appeared to decrease between 2017 and 2018 in all but one site. Enhanced surveillance of hospitalised pertussis in Europe is essential to monitor pertussis epidemiology and disease burden.

Published
2021
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29. The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant

Author

López, Mariana G., Chiner-Oms, Álvaro, García de Viedma, Darío, Ruiz-Rodriguez, Paula, Bracho, Maria Alma, Cancino-Muñoz, Irving, D’Auria, Giuseppe, de Marco, Griselda, García-González, Neris, Goig, Galo Adrian, Gómez-Navarro, Inmaculada, Jiménez-Serrano, Santiago, Martinez-Priego, Llúcia, Ruiz-Hueso, Paula, Ruiz-Roldán, Lidia, Torres-Puente, Manuela, Alberola, Juan, Albert, Eliseo, Aranzamendi Zaldumbide, Maitane, Bea-Escudero, María Pilar, Boga, Jose Antonio, Bordoy, Antoni E., Canut-Blasco, Andrés, Carvajal, Ana, Cilla Eguiluz, Gustavo, Cordón Rodríguez, Maria Luz, Costa-Alcalde, José J., de Toro, María, de Toro Peinado, Inmaculada, del Pozo, Jose Luis, Duchêne, Sebastián, Fernández-Pinero, Jovita, Fuster Escrivá, Begoña, Gimeno Cardona, Concepción, González Galán, Verónica, Gonzalo Jiménez, Nieves, Hernáez Crespo, Silvia, Herranz, Marta, Lepe, José Antonio, López-Causapé, Carla, López-Hontangas, José Luis, Martín, Vicente, Martró, Elisa, Milagro Beamonte, Ana, Montes Ros, Milagrosa, Moreno-Muñoz, Rosario, Navarro, David, Navarro-Marí, José María, Not, Anna, Oliver, Antonio, Palop-Borrás, Begoña, Parra Grande, Mónica, Pedrosa-Corral, Irene, Pérez González, Maria Carmen, Pérez-Lago, Laura, Pérez-Ruiz, Mercedes, Piñeiro Vázquez, Luis, Rabella, Nuria, Rezusta, Antonio, Robles Fonseca, Lorena, Rodríguez-Villodres, Ángel, Sanbonmatsu-Gámez, Sara, Sicilia, Jon, Soriano, Alex, Tirado Balaguer, María Dolores, Torres, Ignacio, Tristancho, Alexander, Marimón, José María, Pérez-Tur, Jordi, Catalán-Alonso, Pilar, Suárez González, Julia, Muñoz, Patricia, Ruiz-Rodríguez, Paula, Bracho, María Alma, Martínez Priego, Llúcia, Galán-Vendrell, Inmaculada, De Marco, Griselda, Ferrús-Abad, María Loreto, Carbó-Ramírez, Sandra, Nogueira, Jose Miguel, Camarena, Juan José, Martínez Expósito, Óscar, Antona Urieta, Nerea, Castelló-Abietar, Cristian, Rojo-Alba, Susana, Álvarez-Argüelles, Marta Elena, Melón, Santiago, Antuori, Adrián, Fernández-Navarro, Anabel, Lecaroz Agara, Maria Concepción, Gómez-González, Carmen, Aguirre-Quiñonero, Amaia, López-Mirones, José Israel, Fernández-Torres, Marina, Almela-Ferrer, Maria Rosario, Fregeneda-Grandes, Juan Miguel, Argüello, Héctor, Sorarrain, Ane, Trastoy, Rocío, Barbeito Castiñeiras, Gema, Coira, Amparo, Pérez del Molino, María Luisa, Aguilera, Antonio, Mediavilla Gradolph, Maria Concepción, Fernández-Alonso, Mirian, González-Recio, Oscar, Gutiérrez-Rivas, Mónica, Jiménez Clavero, Miguel Ángel, Ocete Mochón, María Dolores, Medina-Gonzalez, Rafael, Reina, Jordi, Gómez-Ruiz, Maria Dolores, Gonzalez-Barbera, Eva M., Molina, Antonio J., Fernandez-Villa, Tania, Martínez-Cameo, Nieves Felisa, Gracia-Grataloup, Yolanda, Tirado Balaguer, Maria Dolores, Gómez Alonso, Bárbara, Arjona Zaragozí, Francisco José, Chamizo López, Francisco Javier, Bordes-Benítez, Ana, Rabella, Núria, Navarro, Ferran, Miró, Elisenda, Simarro Córdoba, Encarnación, Lozano-Serra, Julia, Soriano, Álex, Roig Sena, Francisco Javier, Vanaclocha Luna, Hermelinda, Sanmartín, Isabel, García-Souto, Daniel, Pequeño-Valtierra, Ana, Tubio, Jose M. C., Temes, Javier, Rodríguez-Castro, Jorge, Santamarina García, Martín, Rodríguez-Iglesias, Manuel, Galán-Sanchez, Fátima, Rodríguez-Pallares, Salud, Azcona-Gutiérrez, José Manuel, Blasco-Alberdi, Miriam, Mayor, Alfredo, García-Basteiro, Alberto L., Moncunill, Gemma, Dobaño, Carlota, Cisteró, Pau, Mitjà, Oriol, González-Beiras, Camila, Vall-Mayans, Martí, Corbacho-Monné, Marc, Alemany, Andrea, Muñoz-Cuevas, Cristina, Rodríguez-Rodríguez, Guadalupe, Benito, Rafael, Algarate, Sonia, Bueno, Jessica, Vergara-Gómez, Andrea, Martínez, Miguel J., Vila, Jordi, Rubio, Elisa, Peiró-Mestres, Aida, Navero-Castillejos, Jessica, Posada, David, Valverde, Diana, Estévez, Nuria, Fernández-Silva, Iria, de Chiara, Loretta, Gallego-García, Pilar, Varela, Nair, Gómez-Pinedo, Ulises, Gozalo-Margüello, Mónica, Cano García, Maria Eliecer, Méndez-Legaza, José Manuel, Rodríguez-Lozano, Jesus, Siller, María, Pablo-Marcos, Daniel, Ruiz-García, Maria Montserrat, Galiana, Antonio, Sánchez-Almendro, Judith, Gascón Ros, Maria Isabel, Torregrosa-Hetland, Cristina Juana, Pastor Boix, Eva María, Cascales Ramos, Paloma, Garcinuño Enríquez, Pedro Luis, Raga Borja, Salvador, González Cantó, Julia, Martínez Macias, Olalla, de Salazar, Adolfo, Viñuela González, Laura, Chueca, Natalia, García, Federico, Gómez-Camarasa, Cristina, Farga Martí, Amparo, Falcón, Rocío, Domínguez-Márquez, Victoria, Planas, Anna M., Fernández-Cádenas, Israel, Marcos, Maria Ángeles, Ezpeleta, Carmen, Navascués, Ana, Miqueleiz Zapatero, Ana, Segovia, Manuel, Moreno-Docón, Antonio, Viedma, Esther, Recio Martínez, Raúl, Muñoz-Gallego, Irene, Gonzalez-Bodi, Sara, Folgueira, Maria Dolores, Mingorance, Jesús, Dahdouh, Elias, Lázaro-Perona, Fernando, Rodríguez-Tejedor, María, Romero-Gómez, María Pilar, García-Rodríguez, Julio, Galán, Juan Carlos, Rodríguez-Dominguez, Mario, Martínez-García, Laura, Abreu Di Berardino, Melanie, Ponce-Alonso, Manuel, González-Alba, Jose Maria, Sanz-Muñoz, Ivan, Pérez San José, Diana, Gil Fortuño, Maria, Bellido-Blasco, Juan B., Yagüe Muñoz, Alberto, Hernández Pérez, Noelia, Buj Jordá, Helena, Pérez Olaso, Óscar, González Praetorius, Alejandro, Martínez Ramírez, Nora Mariela, Ramírez Marinero, Aida, Padilla León, Eduardo, Vilas Basil, Alba, Canal Aranda, Mireia, Bernet Sánchez, Albert, Bellés Bellés, Alba, López González, Eric, Prats Sánchez, Iván, García-González, Mercè, Martínez-Lirola, Miguel José, Rodríguez Maresca, Manuel Ángel, Cabezas Fernández, Maria Teresa, Carrillo Gil, María Eugenia, Ventero Martín, Maria Paz, Molina Pardines, Carmen, Orta Mira, Nieves, Navarro Cots, María, Vidal Catalá, Inmaculada, García Nava, Isabel, Illescas Fernández-Bermejo, Soledad, Martínez-Alarcón, José, Torres-Narbona, Marta, Colmenarejo, Cristina, García-Agudo, Lidia, Pérez García, Jorge A., Yago López, Martín, Goberna Bravo, María Ángeles, Simón García, Victoria, Llop Furquet, Gonzalo, Iranzo Tatay, Agustín, Moreno-Marro, Sandra, Lozano Rodríguez, Noelia, Broseta Tamarit, Amparo, Badiola Díez, Juan José, Martínez-Ramírez, Amparo, Dopazo, Ana, Callejas, Sergio, Benguría, Alberto, Aguado, Begoña, Alcamí, Antonio, Bermejo Bermejo, Marta, Ramos-Ruíz, Ricardo, Fernández Soria, Víctor Manuel, Simón Soria, Fernando, Roig Cardells, Mercedes, Coscolla, Mireia, González-Candelas, Fernando, Comas, Iñaki, Instituto de Salud Carlos III, Consejo Superior de Investigaciones Científicas (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Research Council, European Commission, Generalitat Valenciana, Chiner-Oms, Álvaro [0000-0002-0463-0101], Ruiz-Rodríguez, Paula [0000-0003-0727-5974], D'Auria, Giuseppe [0000-0003-0672-2541], Gómez-Navarro, Inmaculada [0000-0002-5235-7365], Jiménez Serrano, Santiago [0000-0003-2917-6053], Aranzamendi Zaldumbide, Maitane [0000-0003-2432-7078], Boga, José Antonio [0000-0002-5500-9972], Bordoy, Antoni E. [0000-0002-1165-542X], Costa-Alcalde, José J. [0000-0002-1916-2216], Toro Peinado, Inmaculada de [0000-0002-8151-3275], López-Causapé, Carla [0000-0003-2228-2005], Martín, Vicente [0000-0003-0552-2804], Moreno-Muñoz, Rosario [0000-0002-0185-5612], Parra Grande, Mónica [0000-0002-8330-7467], Balaguer, María Dolores [0000-0003-3808-7300], Coscolla, Mireia [0000-0003-0752-0538], González-Candelas, Fernando [0000-0002-0879-5798], Comas, Iñaki [0000-0001-5504-9408], Ministerio de Ciencia (España), Generalitat Valenciana (España), Chiner-Oms, Álvaro, Ruiz-Rodríguez, Paula, D'Auria, Giuseppe, Gómez-Navarro, Inmaculada, Jiménez Serrano, Santiago, Aranzamendi Zaldumbide, Maitane, Boga, José Antonio, Bordoy, Antoni E., Costa-Alcalde, José J., Toro Peinado, Inmaculada de, López-Causapé, Carla, Martín, Vicente, Moreno-Muñoz, Rosario, Parra Grande, Mónica, Balaguer, María Dolores, Coscolla, Mireia, González-Candelas, Fernando, Comas, Iñaki, and Marimon, Jose Maria

Subjects
DYNAMICS, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Physical Distancing, Biology, Severity of Illness Index, Article, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, Pandemic, Quarantine, Genetics, Humans, Clade, Phylogeny, 030304 developmental biology, 0303 health sciences, Models, Statistical, SARS-CoV-2, Incidence (epidemiology), Incidence, Genetic variants, COVID-19, Genomics, New variant, Dynamics, Virus, 3. Good health, Spain, Communicable Disease Control, VIRUS, 030217 neurology & neurosurgery, Demography
Abstract

SeqCOVID-Spain consortium: Álvaro Chiner-Oms, Irving Cancino-Muñoz, Mariana G. López, Manuela Torres-Puente, Inmaculada Gómez-Navarro, Santiago Jiménez-Serrano, Jordi Pérez-Tur, Darío García de Viedma, Laura Pérez-Lago, Marta Herranz, Jon Sicilia, Pilar Catalán-Alonso, Julia Suárez González, Patricia Muñoz, Mireia Coscolla, Paula Ruiz-Rodríguez, Fernando González-Candelas, Iñaki Comas, Lidia Ruiz-Roldán, María Alma Bracho, Neris García-González, Llúcia Martínez Priego, Inmaculada Galán-Vendrell, Paula Ruiz-Hueso, Griselda De Marco, María Loreto Ferrús-Abad, Sandra Carbó-Ramírez, Giuseppe D’Auria, Galo Adrian Goig, Juan Alberola, Jose Miguel Nogueira, Juan José Camarena, David Navarro, Eliseo Albert, Ignacio Torres, Maitane Aranzamendi Zaldumbide, Óscar Martínez Expósito, Nerea Antona Urieta, María de Toro, María Pilar Bea-Escudero, Jose Antonio Boga, Cristian Castelló-Abietar, Susana Rojo-Alba, Marta Elena Álvarez-Argüelles, Santiago Melón, Elisa Martró, Antoni E. Bordoy, Anna Not, Adrián Antuori, Anabel Fernández-Navarro, Andrés Canut-Blasco, Silvia Hernáez Crespo, Maria Luz Cordón Rodríguez, Maria Concepción Lecaroz Agara, Carmen Gómez-González, Amaia Aguirre-Quiñonero, José Israel López-Mirones, Marina Fernández-Torres, Maria Rosario Almela-Ferrer, Ana Carvajal, Juan Miguel Fregeneda-Grandes, Héctor Argüello, Gustavo Cilla Eguiluz, Milagrosa Montes Ros, Luis Piñeiro Vázquez, Ane Sorarrain, José María Marimón, José J. Costa-Alcalde, Rocío Trastoy, Gema Barbeito Castiñeiras, Amparo Coira, María Luisa Pérez del Molino, Antonio Aguilera, Begoña Palop-Borrás, Inmaculada de Toro Peinado, Maria Concepción Mediavilla Gradolph, Mercedes Pérez-Ruiz, Mirian Fernández-Alonso, Jose Luis del Pozo, Oscar González-Recio, Mónica Gutiérrez-Rivas, Jovita Fernández-Pinero, Miguel Ángel Jiménez Clavero, Begoña Fuster Escrivá, Concepción Gimeno Cardona, María Dolores Ocete Mochón, Rafael Medina-Gonzalez, José Antonio Lepe, Verónica González Galán, Ángel Rodríguez-Villodres, Nieves Gonzalo Jiménez, Jordi Reina, Carla López-Causapé, Maria Dolores Gómez-Ruiz, Eva M. Gonzalez-Barbera, José Luis López-Hontangas, Vicente Martín, Antonio J. Molina, Tania Fernandez-Villa, Ana Milagro Beamonte, Nieves Felisa Martínez-Cameo, Yolanda Gracia-Grataloup, Rosario Moreno-Muñoz, Maria Dolores Tirado Balaguer, José María Navarro-Marí, Irene Pedrosa-Corral, Sara Sanbonmatsu-Gámez, Antonio Oliver, Mónica Parra Grande, Bárbara Gómez Alonso, Francisco José Arjona Zaragozí, Maria Carmen Pérez González, Francisco Javier Chamizo López, Ana Bordes-Benítez, Núria Rabella, Ferran Navarro, Elisenda Miró, Antonio Rezusta, Alexander Tristancho, Encarnación Simarro Córdoba, Julia Lozano-Serra, Lorena Robles Fonseca, Álex Soriano, Francisco Javier Roig Sena, Hermelinda Vanaclocha Luna, Isabel Sanmartín, Daniel García-Souto, Ana Pequeño-Valtierra, Jose M. C. Tubio, Javier Temes, Jorge Rodríguez-Castro, Martín Santamarina García, Manuel Rodríguez-Iglesias, Fátima Galán-Sanchez, Salud Rodríguez-Pallares, José Manuel Azcona-Gutiérrez, Miriam Blasco-Alberdi, Alfredo Mayor, Alberto L. García-Basteiro, Gemma Moncunill, Carlota Dobaño, Pau Cisteró, Oriol Mitjà, Camila González-Beiras, Martí Vall-Mayans, Marc Corbacho-Monné, Andrea Alemany, Cristina Muñoz-Cuevas, Guadalupe Rodríguez-Rodríguez, Rafael Benito, Sonia Algarate, Jessica Bueno, Andrea Vergara-Gómez, Miguel J. Martínez, Jordi Vila, Elisa Rubio, Aida Peiró-Mestres, Jessica Navero-Castillejos, David Posada, Diana Valverde, Nuria Estévez, Iria Fernández-Silva, Loretta de Chiara, Pilar Gallego-García, Nair Varela, Ulises Gómez-Pinedo, Mónica Gozalo-Margüello, Maria Eliecer Cano García, José Manuel Méndez-Legaza, Jesus Rodríguez-Lozano, María Siller, Daniel Pablo-Marcos, Maria Montserrat Ruiz-García, Antonio Galiana, Judith Sánchez-Almendro, Maria Isabel Gascón Ros, Cristina Juana Torregrosa-Hetland, Eva María Pastor Boix, Paloma Cascales Ramos, Pedro Luis Garcinuño Enríquez, Salvador Raga Borja, Julia González Cantó, Olalla Martínez Macias, Adolfo de Salazar, Laura Viñuela González, Natalia Chueca, Federico García, Cristina Gómez-Camarasa, Amparo Farga Martí, Rocío Falcón, Victoria Domínguez-Márquez, Anna M. Planas, Israel Fernández-Cádenas, Maria Ángeles Marcos, Carmen Ezpeleta, Ana Navascués, Ana Miqueleiz Zapatero, Manuel Segovia, Antonio Moreno-Docón, Esther Viedma, Raúl Recio Martínez, Irene Muñoz-Gallego, Sara Gonzalez-Bodi, Maria Dolores Folgueira, Jesús Mingorance, Elias Dahdouh, Fernando Lázaro-Perona, María Rodríguez-Tejedor, María Pilar Romero-Gómez, Julio García-Rodríguez, Juan Carlos Galán, Mario Rodríguez-Dominguez, Laura Martínez-García, Melanie Abreu Di Berardino, Manuel Ponce-Alonso, Jose Maria González-Alba, Ivan Sanz-Muñoz, Diana Pérez San José, Maria Gil Fortuño, Juan B. Bellido-Blasco, Alberto Yagüe Muñoz, Noelia Hernández Pérez, Helena Buj Jordá, Óscar Pérez Olaso, Alejandro González Praetorius, Nora Mariela Martínez Ramírez, Aida Ramírez Marinero, Eduardo Padilla León, Alba Vilas Basil, Mireia Canal Aranda, Albert Bernet Sánchez, Alba Bellés Bellés, Eric López González, Iván Prats Sánchez, Mercè García-González, Miguel José Martínez-Lirola, Manuel Ángel Rodríguez Maresca, Maria Teresa Cabezas Fernández, María Eugenia Carrillo Gil, Maria Paz Ventero Martín, Carmen Molina Pardines, Nieves Orta Mira, María Navarro Cots, Inmaculada Vidal Catalá, Isabel García Nava, Soledad Illescas Fernández-Bermejo, José Martínez-Alarcón, Marta Torres-Narbona, Cristina Colmenarejo, Lidia García-Agudo, Jorge A. Pérez García, Martín Yago López, María Ángeles Goberna Bravo, Victoria Simón García, Gonzalo Llop Furquet, Agustín Iranzo Tatay, Sandra Moreno-Marro, Noelia Lozano Rodríguez, Amparo Broseta Tamarit, Juan José Badiola Díez, Amparo Martínez-Ramírez, Ana Dopazo, Sergio Callejas, Alberto Benguría, Begoña Aguado, Antonio Alcamí, Marta Bermejo Bermejo, Ricardo Ramos-Ruíz, Víctor Manuel Fernández Soria, Fernando Simón Soria & Mercedes Roig Cardells, The coronavirus disease 2019 (COVID-19) pandemic has affected the world radically since 2020. Spain was one of the European countries with the highest incidence during the first wave. As a part of a consortium to monitor and study the evolution of the epidemic, we sequenced 2,170 samples, diagnosed mostly before lockdown measures. Here, we identified at least 500 introductions from multiple international sources and documented the early rise of two dominant Spanish epidemic clades (SECs), probably amplified by superspreading events. Both SECs were related closely to the initial Asian variants of SARS-CoV-2 and spread widely across Spain. We inferred a substantial reduction in the effective reproductive number of both SECs due to public-health interventions (Re, This work was mainly funded by the Instituto de Salud Carlos III project COV20/00140, with additional funding by Spanish National Research Council project CSIC-COV19-021, Ministerio de Ciencia project PID2019-104477RB-100, ERC StG 638553 and ERC CoG 101001038 to I.C., and BFU2017-89594R to F.G.C. M.C. is supported by Ramón y Cajal program from Ministerio de Ciencia and grants RTI2018-094399-A-I00 and Generalitat Valenciana (Regional Government) project SEJI/2019/011. We gratefully acknowledge Hospital Universitari Vall d’Hebron, Instituto de Salud Carlos III, IrsiCaixa AIDS Research Lab and all the international researchers and institutions that submitted sequenced SARS-CoV-2 genomes to the GISAID’s EpiCov Database (Supplementary Table 1), as an important part of our analyses has been made possible by the sharing of their work. We also thank Unidad de Bioinformática y Estadística, Centro de Investigación Príncipe Felipe, for allowing us to use the Computer Cluster to perform some of the bioinformatic analysis.

Published
2021

30. Emergence of SARS-CoV-2 variant B.1.575.2 containing the E484K mutation in the spike protein in Pamplona (Spain) May-June 2021

Author

Trobajo-Sanmartín, Camino, primary, Miqueleiz, Ana, additional, Portillo, María Eugenia, additional, Fernández-Huerta, Miguel, additional, Navascués, Ana, additional, Sola Sara, Pilar, additional, Moreno, Paula López, additional, Ordoñez, Gonzalo R, additional, Castilla, Jesús, additional, and Ezpeleta, Carmen, additional

Published
2021
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32. Effect of influenza vaccination in patients with asthma

Author

Martínez-Baz, Iván, primary, Navascués, Ana, additional, Casado, Itziar, additional, Portillo, María Eugenia, additional, Guevara, Marcela, additional, Gómez-Ibáñez, Carlos, additional, Burgui, Cristina, additional, Ezpeleta, Carmen, additional, and Castilla, Jesús, additional

Published
2021
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33. Surveillance for Enteroviruses Associated with Hand, Foot, and Mouth Disease, and Other Mucocutaneous Symptoms in Spain, 2006–2020

Author

Martínez-López, Nieves, primary, Muñoz-Almagro, Carmen, additional, Launes, Cristian, additional, Navascués, Ana, additional, Imaz-Pérez, Manuel, additional, Reina, Jordi, additional, Romero, María Pilar, additional, Calvo, Cristina, additional, Ruiz-García, Montserrat, additional, Megias, Gregoria, additional, Valencia-Ramos, Juan, additional, Otero, Almudena, additional, and Cabrerizo, María, additional

Published
2021
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39. Molecular epidemiology of an enterovirus A71 outbreak associated with severe neurological disease, Spain, 2016

Author

González-Sanz, Rubén, Casas-Alba, Didac, Launes, Cristian, Muñoz-Almagro, Carmen, Ruiz-García, María Montserrat, Alonso, Mercedes, González-Abad, María José, Megías, Gregoria, Rabella, Núria, del Cuerpo Casas, Margarita, Gozalo-Margüello, Mónica, González-Praetorius, Alejandro, Martínez-Sapiña, Ana, Goyanes-Galán, María José, Romero, María Pilar, Calvo, Cristina, Antón, Andrés, Imaz, Manuel, Aranzamendi Zaldumbide, Maitane, Hernández Rodríguez, Águeda., Moreno-Docón, Antonio, Rey-Cao, Sonia, Navascués, Ana, Otero, Almudena, Cabrerizo, María, Universitat Autònoma de Barcelona, Institut Català de la Salut, [González-Sanz R] Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain. [Casas-Alba D] Institut de Recerca Sant Joan de Déu, Barcelona, Spain. [Launes C] CIBER de epidemiología y Salud Pública, Madrid, Spain. Institut de Recerca Sant Joan de Déu, Barcelona, Spain. [Muñoz-Almagro C] CIBER de epidemiología y Salud Pública, Madrid, Spain. Universitat Internacional de Catalunya, Barcelona, Spain. Institut de Recerca Sant Joan de Déu, Barcelona, Spain. [Ruiz-García MM] Hospital General de Elche, Alicante, Spain. [Alonso M] Hospital Infantil Universitario Niño Jesús, Madrid, Spain. [Antón A] Hospital Universitari Vall d'Hebron, Barcelona, Spain., and Vall d'Hebron Barcelona Hospital Campus

Subjects
0301 basic medicine, Pediatrics, virus::virus ARN::Picornaviridae::enterovirus [ORGANISMOS], Epidemiology, encephalitis, Other subheadings::Other subheadings::/epidemiology [Other subheadings], medicine.disease_cause, Encefalomielitis, Disease Outbreaks, Viruses::RNA Viruses::Picornaviridae::Enterovirus [ORGANISMS], Environment and Public Health::Public Health::Disease Outbreaks [HEALTH CARE], Encephalomyelitis, Antigens, Viral, Respiratory Tract Infections, Phylogeny, Enterovirus, Molecular Epidemiology, Surveillance, Foot-and-mouth disease, Reverse Transcriptase Polymerase Chain Reaction, enterovirus, Incidence (epidemiology), Otros calificadores::Otros calificadores::/epidemiología [Otros calificadores], Virus, Virus - Epidemiologia - Espanya, 3. Good health, Hospitalization, Phylogeography, Geographic Locations::Europe::Spain [GEOGRAPHICALS], Neurology, Child, Preschool, outbreaks, surveillance, RNA, Viral, Encephalitis, Ubicaciones Geográficas::Europa (Continente)::España [DENOMINACIONES GEOGRÁFICAS], enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::encefalitis [ENFERMEDADES], medicine.medical_specialty, 616.8, Epidemiologia molecular, 030106 microbiology, Disease cluster, Neurologia, 03 medical and health sciences, Virology, Enterovirus Infections, medicine, Epidemiología, Humans, Meningitis, Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Encephalitis [DISEASES], Epidemiologia, Neurología, Retrospective Studies, ambiente y salud pública::salud pública::brotes de enfermedades [ATENCIÓN DE SALUD], Neurologia - Malalties, Molecular epidemiology, Sequence Analysis, RNA, business.industry, Research, Outbreaks, Public Health, Environmental and Occupational Health, Infant, Outbreak, Sequence Analysis, DNA, medicine.disease, Enterovirus A, Human, 030104 developmental biology, Spain, Nervous System Diseases, business
Abstract

Enterovirus 71 (EV-A71) is a small, non-enveloped, single-stranded RNA virus that belongs to the species Enterovirus A along with 24 other serotypes within the Enterovirus genus [1]. According to the VP1 protein sequence, EV-A71 is classified into six genogroups (A–F) and a number of subgenogroups (B0–B5, C1–C5) [2]. Although EV-A71 infection is often asymptomatic, it can cause disorders with a wide range of clinical manifestations from non-specific febrile illness, aseptic meningitis and mild mucocutaneous symptoms to severe neurological diseases such as brainstem encephalitis and acute flaccid paralysis (AFP) [3,4]. EV-A71 is distributed worldwide. However, the largest outbreaks associated with hand, foot and mouth disease (HFMD) with subsequent neurological and cardiopulmonary complications have been described in the Asia-Pacific region, especially in the past 20 years [2,5-7]. These outbreaks have been connected to the circulation of different subgenogroups (B3, B4, C1, C2 and C4) [8-14]. In Europe, although outbreaks of polio-like disease occurred in Hungary and Bulgaria in the 1970s [15,16], only sporadic cases have been reported from several countries in recent years, mainly caused by the C1 and C2 subgenogroups [2,17]. In 2015, a new recombinant EV-A71 variant was identified that affected at least 19 young children in different areas of Germany [18]. This infection was associated with neurological manifestations (cerebral seizures, myoclonia and ataxia) that required hospitalisation. There were no reports of fatal cases or clinical sequelae after hospital discharge. Moreover, a well-documented case, a 2-year-old girl, required hospitalisation and was diagnosed with brainstem encephalitis and cardiopulmonary complications with an outcome of a probable persistent neurological impairment [19]. In addition, 18 cases of severe neurological disease associated with EV-A71 infection, and phylogenetically closely related to the strains described in Germany, were reported in France between May and October 2016. Patients presented with rhombencephalitis, encephalitis or encephalomyelitis, and one fatal case of acute cardiac failure was reported [20]. The same strain was also involved in a sporadic case of encephalitis in Poland during summer 2016 [21]. In Spain, EV-A71 was circulating at a very low rate until 2015 [22,23]. In the spring of 2016, however, a large outbreak associated with severe neurological diseases was reported in the region of Catalonia [24-26] and further disseminated to the rest of the country. In the present study, we investigated the clinical manifestations of EV-A71 infections and the molecular epidemiology and geographical spread of the strains detected in Spain in 2016, comparing them to strains circulating in Spain and other countries in recent years. info:eu-repo/semantics/publishedVersion

Published
2019
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46. Effect of Influenza Vaccination in Preventing Laboratory-Confirmed Influenza Hospitalization in Patients With Diabetes Mellitus.

Author

Martínez-Baz, Iván, Navascués, Ana, Portillo, María Eugenia, Casado, Itziar, Fresán, Ujué, Ezpeleta, Carmen, and Castilla, Jesús

Subjects
*INFLUENZA vaccines, *DRUG efficacy, *IMMUNIZATION, *CONFIDENCE intervals, *CASE-control method, *HOSPITAL care, *INFLUENZA, *DESCRIPTIVE statistics, *ODDS ratio
Abstract

Background People with diabetes are at high risk of severe influenza complications. The influenza vaccination effect among diabetic patients remains inconclusive. We estimated the average effect of influenza vaccination status in the current and prior seasons in preventing laboratory-confirmed influenza hospitalization in diabetic patients. Methods Patients attended in hospitals and primary healthcare centers with influenza-like illness were tested for influenza from the 2013–2014 to 2018–2019 seasons in Navarre, Spain. A test-negative case-control design in diabetic inpatients compared the influenza vaccination status in the current and 5 prior seasons between laboratory-confirmed influenza cases and negative controls. Vaccination status of influenza-confirmed cases was compared between diabetic inpatients and outpatients. Influenza vaccination effect was compared between diabetic patients and older (≥ 60 years) or chronic nondiabetic patients. Results Of 1670 diabetic inpatients tested, 569 (34%) were confirmed for influenza and 1101 were test-negative controls. The average effect in preventing influenza hospitalization was 46% (95% confidence interval [CI], 28%–59%) for current-season vaccination and 44% (95% CI, 20%–61%) for vaccination in prior seasons only in comparison to unvaccinated patients in the current and prior seasons. Among diabetic patients with confirmed influenza, current-season vaccination reduced the probability of hospitalization (adjusted odds ratio, 0.35; 95% CI,.15–.79). In diabetic patients, vaccination effect against influenza hospitalizations was not inferior to that in older or chronic nondiabetic patients. Conclusions On average, influenza vaccination of diabetic population reduced by around half the risk of influenza hospitalization. Vaccination in prior seasons maintained a notable protective effect. These results reinforce the recommendation of influenza vaccination for diabetic patients. [ABSTRACT FROM AUTHOR]

Published
2021
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48. Enterovirus D68-associated respiratory and neurological illness in Spain, 2014–2018

Author

González-Sanz, Rubén, primary, Taravillo, Irene, additional, Reina, Jordi, additional, Navascués, Ana, additional, Moreno-Docón, Antonio, additional, Aranzamendi, Maitane, additional, Romero, María Pilar, additional, del Cuerpo, Margarita, additional, Pérez-González, Carmen, additional, Pérez-Castro, Sonia, additional, Otero, Almudena, additional, and Cabrerizo, María, additional

Published
2019
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49. Independent Role of Severe Obesity as a Risk Factor for COVID‐19 Hospitalization: A Spanish Population‐Based Cohort Study.

Author

Fresán, Ujué, Guevara, Marcela, Elía, Fernando, Albéniz, Esther, Burgui, Cristina, Castilla, Jesús, Martín, Carmen, Navascués, Ana, Portillo, María Eugenia, Polo, Isabel, Ezpeleta, Carmen, Gorricho, Javier, Ardanaz, Eva, Ascunce, Nieves, Arriazu, Maite, Barricarte, Aurelio, Barriuso, Laura, Casado, Itziar, Díaz, Jorge, and Ederra, María

Subjects
COVID-19, COHORT analysis, HOSPITAL care, INTENSIVE care units, POISSON regression
Abstract

Objectives: This study analyzed the association between severe obesity and coronavirus disease 2019 (COVID‐19) hospitalization and severe disease. Methods: The incidence of hospitalization for laboratory‐confirmed COVID‐19 was evaluated in a prospective population‐based cohort of 433,995 persons aged 25 to 79 years in Spain during March and April of 2020. Persons with and without class 3 obesity were compared using Poisson regression to estimate the adjusted relative risk (aRR) from class 3 obesity of COVID‐19 hospitalization and of severe disease (intensive care unit admission or death). Differences in the effect by age, sex, and chronic conditions were evaluated. Results: Individuals with class 3 obesity had a higher risk of hospitalization (aRR = 2.20, 95% CI: 1.66‐2.93) and developing severe COVID‐19 (aRR = 2.30, 95% CI: 1.20‐4.40). In people younger than 50 years, these effects were more pronounced (aRR = 5.02, 95% CI: 3.19‐7.90 and aRR = 13.80, 95% CI: 3.11‐61.17, respectively), whereas no significant effects were observed in those aged 65 to 79 years (aRR = 1.22, 95% CI: 0.70‐2.12 and aRR = 1.42, 95% CI: 0.52‐3.88, respectively). Sex and chronic conditions did not modify the effect of class 3 obesity in any of the outcomes. Conclusions: Severe obesity is a relevant risk factor for COVID‐19 hospitalization and severity in young adults, having a magnitude similar to that of aging. Tackling the current obesity pandemic could alleviate the impact of chronic and infectious diseases. [ABSTRACT FROM AUTHOR]

Published
2021
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