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2. Pharmacological activation of constitutive androstane receptor induces female-specific modulation of hepatic metabolism

Author

Huillet, Marine, Lasserre, Frédéric, Gratacap, Marie-Pierre, Engelmann, Beatrice, Bruse, Justine, Polizzi, Arnaud, Fougeray, Tiffany, Martin, Céline Marie Pauline, Rives, Clémence, Fougerat, Anne, Naylies, Claire, Lippi, Yannick, Garcia, Géraldine, Rousseau-Bacquie, Elodie, Canlet, Cécile, Debrauwer, Laurent, Rolle-Kampczyk, Ulrike, von Bergen, Martin, Payrastre, Bernard, Boutet-Robinet, Elisa, Gamet-Payrastre, Laurence, Guillou, Hervé, Loiseau, Nicolas, and Ellero-Simatos, Sandrine

Published
2024
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3. Obesity promotes fumonisin B1 hepatotoxicity

Author

Dopavogui, Léonie, Régnier, Marion, Polizzi, Arnaud, Ponchon, Quentin, Smati, Sarra, Klement, Wendy, Lasserre, Frédéric, Lukowicz, Céline, Lippi, Yannick, Fougerat, Anne, Bertrand-Michel, Justine, Naylies, Claire, Canlet, Cécile, Debrauwer, Laurent, Rousseau-Bacquié, Elodie, Gamet-Payrastre, Laurence, Dauriat, Charlène, Casas, Josefina, Croubels, Siska, De Baere, Siegrid, Burger, Hester M., Chassaing, Benoit, Ellero-Simatos, Sandrine, Guillou, Hervé, Oswald, Isabelle P., and Loiseau, Nicolas

Published
2023
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7. The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice

Author

Barretto, Sharon Ann, Lasserre, Frederic, Huillet, Marine, Régnier, Marion, Polizzi, Arnaud, Lippi, Yannick, Fougerat, Anne, Person, Elodie, Bruel, Sandrine, Bétoulières, Colette, Naylies, Claire, Lukowicz, Céline, Smati, Sarra, Guzylack, Laurence, Olier, Maïwenn, Théodorou, Vassilia, Mselli-Lakhal, Laila, Zalko, Daniel, Wahli, Walter, Loiseau, Nicolas, Gamet-Payrastre, Laurence, Guillou, Hervé, and Ellero-Simatos, Sandrine

Published
2021
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9. Dietary Amino Acid Source Elicits Sex‐Specific Metabolic Response to Diet‐Induced NAFLD in Mice

Author

Rives, Clémence, primary, Martin, Céline Marie Pauline, additional, Evariste, Lauris, additional, Polizzi, Arnaud, additional, Huillet, Marine, additional, Lasserre, Frédéric, additional, Alquier‐Bacquie, Valérie, additional, Perrier, Prunelle, additional, Gomez, Jelskey, additional, Lippi, Yannick, additional, Naylies, Claire, additional, Levade, Thierry, additional, Sabourdy, Frédérique, additional, Remignon, Hervé, additional, Fafournoux, Pierre, additional, Chassaing, Benoit, additional, Loiseau, Nicolas, additional, Guillou, Hervé, additional, Ellero‐Simatos, Sandrine, additional, Gamet‐Payrastre, Laurence, additional, and Fougerat, Anne, additional

Published
2023
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10. The protective role of liver X receptor (LXR) during fumonisin B1-induced hepatotoxicity

Author

Régnier, Marion, Polizzi, Arnaud, Lukowicz, Céline, Smati, Sarra, Lasserre, Frédéric, Lippi, Yannick, Naylies, Claire, Laffitte, Joelle, Bétoulières, Colette, Montagner, Alexandra, Ducheix, Simon, Gourbeyre, Pascal, Ellero-Simatos, Sandrine, Menard, Sandrine, Bertrand-Michel, Justine, Al Saati, Talal, Lobaccaro, Jean-Marc, Burger, Hester M., Gelderblom, Wentzel C., Guillou, Hervé, Oswald, Isabelle P., and Loiseau, Nicolas

Published
2019
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12. Author Correction: Dimorphic metabolic and endocrine disorders in mice lacking the constitutive androstane receptor

Author

Lukowicz, Céline, Ellero-Simatos, Sandrine, Régnier, Marion, Oliviero, Fabiana, Lasserre, Frédéric, Polizzi, Arnaud, Montagner, Alexandra, Smati, Sarra, Boudou, Frédéric, Lenfant, Françoise, Guzylack-Pirou, Laurence, Menard, Sandrine, Barretto, Sharon, Fougerat, Anne, Lippi, Yannick, Naylies, Claire, Bertrand-Michel, Justine, Belgnaoui, Afifa Ait, Theodorou, Vassilia, Marchi, Nicola, Gourdy, Pierre, Gamet-Payrastre, Laurence, Loiseau, Nicolas, Guillou, Hervé, and Mselli-Lakhal, Laïla

Published
2020
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13. Dimorphic metabolic and endocrine disorders in mice lacking the constitutive androstane receptor

Author

Lukowicz, Céline, Ellero-Simatos, Sandrine, Régnier, Marion, Oliviero, Fabiana, Lasserre, Frédéric, Polizzi, Arnaud, Montagner, Alexandra, Smati, Sarra, Boudou, Frédéric, Lenfant, Françoise, Guzylack-Pirou, Laurence, Menard, Sandrine, Barretto, Sharon, Fougerat, Anne, Lippi, Yannick, Naylies, Claire, Bertrand-Michel, Justine, Belgnaoui, Afifa Ait, Theodorou, Vassilia, Marchi, Nicola, Gourdy, Pierre, Gamet-Payrastre, Laurence, Loiseau, Nicolas, Guillou, Hervé, and Mselli-Lakhal, Laïla

Published
2019
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14. Haem iron reshapes colonic luminal environment: impact on mucosal homeostasis and microbiome through aldehyde formation

Author

Martin, Océane C. B., Olier, Maïwenn, Ellero-Simatos, Sandrine, Naud, Nathalie, Dupuy, Jacques, Huc, Laurence, Taché, Sylviane, Graillot, Vanessa, Levêque, Mathilde, Bézirard, Valérie, Héliès-Toussaint, Cécile, Estrada, Florence Blas Y., Tondereau, Valérie, Lippi, Yannick, Naylies, Claire, Peyriga, Lindsey, Canlet, Cécile, Davila, Anne Marie, Blachier, François, Ferrier, Laurent, Boutet-Robinet, Elisa, Guéraud, Françoise, Théodorou, Vassilia, and Pierre, Fabrice H. F.

Published
2019
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15. Obesity promotes fumonisin B1 hepatotoxicity

Author

European Research Council, Dopavogui, Léonie, Régnier, Marion, Polizzi, Arnaud, Ponchon, Quentin, Smati, Sarra, Klement, Wendy, Lasserre, Frédéric, Lukowicz, Céline, Lippi, Yannick, Fougerat, Anne, Bertrand-Michel, Justine, Naylies, Claire, Canlet, Cécile, Debrauwer, Laurent, Rousseau-Bacquié, Elodie, Gamet-Payrastre, Laurence, Dauriat, Charlène, Casas, Josefina, Croubels, Siska, De Baere, Siegrid, Burger, Hester M., Chassaing, Benoit, Ellero-Simatos, Sandrine, Guillou, Hervé, Oswald, Isabelle P., Loiseau, Nicolas, European Research Council, Dopavogui, Léonie, Régnier, Marion, Polizzi, Arnaud, Ponchon, Quentin, Smati, Sarra, Klement, Wendy, Lasserre, Frédéric, Lukowicz, Céline, Lippi, Yannick, Fougerat, Anne, Bertrand-Michel, Justine, Naylies, Claire, Canlet, Cécile, Debrauwer, Laurent, Rousseau-Bacquié, Elodie, Gamet-Payrastre, Laurence, Dauriat, Charlène, Casas, Josefina, Croubels, Siska, De Baere, Siegrid, Burger, Hester M., Chassaing, Benoit, Ellero-Simatos, Sandrine, Guillou, Hervé, Oswald, Isabelle P., and Loiseau, Nicolas

Abstract

Obesity, which is a worldwide public health issue, is associated with chronic inflammation that contribute to long-term complications, including insulin resistance, type 2 diabetes and non-alcoholic fatty liver disease. We hypothesized that obesity may also influence the sensitivity to food contaminants, such as fumonisin B1 (FB1), a mycotoxin produced mainly by the Fusarium verticillioides. FB1, a common contaminant of corn, is the most abundant and best characterized member of the fumonisins family. We investigated whether diet-induced obesity could modulate the sensitivity to oral FB1 exposure, with emphasis on gut health and hepatotoxicity. Thus, metabolic effects of FB1 were assessed in obese and non-obese male C57BL/6J mice. Mice received a high-fat diet (HFD) or normal chow diet (CHOW) for 15 weeks. Then, during the last three weeks, mice were exposed to these diets in combination or not with FB1 (10 mg/kg body weight/day) through drinking water. As expected, HFD feeding induced significant body weight gain, increased fasting glycemia, and hepatic steatosis. Combined exposure to HFD and FB1 resulted in body weight loss and a decrease in fasting blood glucose level. This co-exposition also induces gut dysbiosis, an increase in plasma FB1 level, a decrease in liver weight and hepatic steatosis. Moreover, plasma transaminase levels were significantly increased and associated with liver inflammation in HFD/FB1-treated mice. Liver gene expression analysis revealed that the combined exposure to HFD and FB1 was associated with reduced expression of genes involved in lipogenesis and increased expression of immune response and cell cycle-associated genes. These results suggest that, in the context of obesity, FB1 exposure promotes gut dysbiosis and severe liver inflammation. To our knowledge, this study provides the first example of obesity-induced hepatitis in response to a food contaminant.

Published
2023

16. Dietary Amino Acid Source Elicits Sex‐Specific Metabolic Response to Diet‐Induced NAFLD in Mice.

Author

Rives, Clémence, Martin, Céline Marie Pauline, Evariste, Lauris, Polizzi, Arnaud, Huillet, Marine, Lasserre, Frédéric, Alquier‐Bacquie, Valérie, Perrier, Prunelle, Gomez, Jelskey, Lippi, Yannick, Naylies, Claire, Levade, Thierry, Sabourdy, Frédérique, Remignon, Hervé, Fafournoux, Pierre, Chassaing, Benoit, Loiseau, Nicolas, Guillou, Hervé, Ellero‐Simatos, Sandrine, and Gamet‐Payrastre, Laurence

Published
2024
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18. Pharmacological activation of constitutive androstane receptor induces female-specific modulation of hepatic metabolism

Author

Huillet Marine, Lasserre Frédéric, Gratacap Marie-Pierre, Engelmann Beatrice, Bruse Justine, Polizzi Arnaud, Fougeray Tiffany, Martin Céline, Rives Clémence, Fougerat Anne, Naylies Claire, Lippi Yannick, Garcia Géraldine, Rousseau- Bacquie Elodie, Canlet Cécile, Debrauwer Laurent, Rolle-Kampczyk Ulrike, von Bergen Martin, Payrastre Bernard, Boutet-Robinet Elisa, Gamet-Payrastre Laurence, Guillou Hervé, Loiseau Nicolas, and Ellero-Simatos Sandrine

Abstract

Background and AimsThe constitutive androstane receptor (CAR) is a nuclear receptor able to recognize a large panel of xenobiotics leading to the modulation of the expression of its target genes involved in xenobiotic detoxication and energy metabolism. While CAR hepatic activity is thought to be higher in women than in men, its response to an acute pharmacological activation has never been investigated in both sexes.MethodsHepatic transcriptome, plasma and hepatic metabolome, have been analyzed inCar+/+andCar-/-male and female mice treated either with the CAR-specific agonist, 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP), or with vehicle.ResultsWhile 90% of TCPOBOP-sensitive genes were modulated in a sex- independent way, the remaining 10% were almost exclusively impacted in female liver specifically. These female-specific CAR-sensitive genes were mainly involved in xenobiotic metabolism, inflammation and extracellular matrix organization. CAR activation also induced higher hepatic oxidative stress and hepatocyte cytolysis in females than in males. Data mining on human data confirmed that CAR activation may be involved in sexually-dimorphic drug-induced liver injury. Hepatic expression of flavin monooxygenase 3(Fmo3)was almost abolished and associated with a decrease of hepatic trimethylamine-N-oxide (TMAO) concentration in TCPOBOP-treated females. In line with a possible role in the control of TMAO homeostasis, CAR activation decreased platelet hyperresponsiveness in female mice supplemented with dietary choline.ConclusionsOur results demonstrate that more than 10% of CAR-sensitive genes are sex-specific and influence hepatic and systemic response such as platelet aggregation. Also, CAR activation may be an important mechanism of sexually- dimorphic drug-induced liver injury.

Published
2023
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19. Obesity promotes Fumonisin B1 toxicity and induces hepatitis

Author

Dopavogui, Léonie, primary, Régnier, Marion, additional, Polizzi, Arnaud, additional, Ponchon, Quentin, additional, Smati, Sarra, additional, Klement, Wendy, additional, Lasserre, Frédéric, additional, Lukowicz, Céline, additional, Lippi, Yannick, additional, Fougerat, Anne, additional, Bertrand-Michel, Justine, additional, Naylies, Claire, additional, Canlet, Cécile, additional, Debrauwer, Laurent, additional, Gamet-Payrastre, Laurence, additional, Dauriat, Charlène, additional, Casas, Josefina, additional, Croubels, Siska, additional, De Baere, Siegrid, additional, Burger, Hester M., additional, Chassaing, Benoit, additional, Ellero-Simatos, Sandrine, additional, Guillou, Hervé, additional, Oswald, Isabelle P., additional, and Loiseau, Nicolas, additional

Published
2022
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20. The hepatocyte insulin receptor is required to program the liver clock and rhythmic gene expression

Author

Fougeray, Tiffany, Polizzi, Arnaud, Régnier, Marion, Fougerat, Anne, Ellero-Simatos, Sandrine, Lippi, Yannick, Smati, Sarra, Lasserre, Frédéric, Tramunt, Blandine, Huillet, Marine, Dopavogui, Léonie, Salvi, Juliette, Nédélec, Emmanuelle, Gigot, Vincent, Smith, Lorraine, Naylies, Claire, Sommer, Caroline, Haas, Joel T., Wahli, Walter, Duez, Hélène, Gourdy, Pierre, Gamet-Payrastre, Laurence, Benani, Alexandre, Burnol, Anne-Françoise, Loiseau, Nicolas, Postic, Catherine, Montagner, Alexandra, and Guillou, Hervé

Published
2022
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21. Tissular Genomic Responses to Oral FB1 Exposure in Pigs

Author

Dopavogui, Léonie, primary, Polizzi, Arnaud, additional, Fougerat, Anne, additional, Gourbeyre, Pascal, additional, Terciolo, Chloé, additional, Klement, Wendy, additional, Pinton, Philippe, additional, Laffite, Joëlle, additional, Cossalter, Anne-Marie, additional, Bailly, Jean-Denis, additional, Puel, Olivier, additional, Lippi, Yannick, additional, Naylies, Claire, additional, Guillou, Hervé, additional, Oswald, Isabelle P., additional, and Loiseau, Nicolas, additional

Published
2022
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23. Additional file 14 of The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice

Author

Barretto, Sharon Ann, Lasserre, Frederic, Huillet, Marine, Régnier, Marion, Polizzi, Arnaud, Lippi, Yannick, Fougerat, Anne, Person, Elodie, Bruel, Sandrine, Bétoulières, Colette, Naylies, Claire, Lukowicz, Céline, Sarra Smati, Guzylack, Laurence, Olier, Maïwenn, Théodorou, Vassilia, Mselli-Lakhal, Laila, Zalko, Daniel, Wahli, Walter, Loiseau, Nicolas, Gamet-Payrastre, Laurence, Guillou, Hervé, and Ellero-Simatos, Sandrine

Abstract

Additional file 13. [14C]-testosterone metabolites structure hypotheses based on their mass and on the similarity of their retention time with authentic standards.

Published
2021
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24. Additional file 3 of The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice

Author

Barretto, Sharon Ann, Lasserre, Frederic, Huillet, Marine, Régnier, Marion, Polizzi, Arnaud, Lippi, Yannick, Fougerat, Anne, Person, Elodie, Bruel, Sandrine, Bétoulières, Colette, Naylies, Claire, Lukowicz, Céline, Sarra Smati, Guzylack, Laurence, Olier, Maïwenn, Théodorou, Vassilia, Mselli-Lakhal, Laila, Zalko, Daniel, Wahli, Walter, Loiseau, Nicolas, Gamet-Payrastre, Laurence, Guillou, Hervé, and Ellero-Simatos, Sandrine

Abstract

Additional file 2. Oligonucleotide sequences for real-time PCR.

Published
2021
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25. Additional file 8 of The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice

Author

Barretto, Sharon Ann, Lasserre, Frederic, Huillet, Marine, Régnier, Marion, Polizzi, Arnaud, Lippi, Yannick, Fougerat, Anne, Person, Elodie, Bruel, Sandrine, Bétoulières, Colette, Naylies, Claire, Lukowicz, Céline, Sarra Smati, Guzylack, Laurence, Olier, Maïwenn, Théodorou, Vassilia, Mselli-Lakhal, Laila, Zalko, Daniel, Wahli, Walter, Loiseau, Nicolas, Gamet-Payrastre, Laurence, Guillou, Hervé, and Ellero-Simatos, Sandrine

Subjects
digestive system, digestive system diseases
Abstract

Additional file 7 Effect of PXR deletion on sexually-dimorphic gene expression. (A) Number of male-biased genes (established in Pxr+/+ mice, see methods) that remain male-biased in Pxr-/- mice. (B) Number of female-biased genes (established in Pxr+/+ mice, see methods) that remain female-biased in Pxr-/- mice. (C) Hierarchical clustering of all genes significantly different for at least one comparison between the 4 experimental groups (Pxr+/+ males, Pxr+/+ females, Pxr-/- males, Pxr-/- females. (D) Average expression Z-scores over gene clusters defined in (C). (E) Pathway enrichment analysis of the 1419 hepatic genes from cluster 1.

Published
2021
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26. Additional file 5 of The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice

Author

Barretto, Sharon Ann, Lasserre, Frederic, Huillet, Marine, Régnier, Marion, Polizzi, Arnaud, Lippi, Yannick, Fougerat, Anne, Person, Elodie, Bruel, Sandrine, Bétoulières, Colette, Naylies, Claire, Lukowicz, Céline, Sarra Smati, Guzylack, Laurence, Olier, Maïwenn, Théodorou, Vassilia, Mselli-Lakhal, Laila, Zalko, Daniel, Wahli, Walter, Loiseau, Nicolas, Gamet-Payrastre, Laurence, Guillou, Hervé, and Ellero-Simatos, Sandrine

Subjects
digestive system, digestive system diseases
Abstract

Additional file 4 Caecal microbiota comparison of Pxr-/- vs. Pxr+/+ male and female mice. (A) α-diversity at the OTU level in Pxr-/- vs. Pxr+/+ males. (B) α-diversity at the OTU levels in Pxr-/- vs. Pxr+/+ females. (C) PLS-DA at the OTU level. Each dot represents one individual sample. (D) Composition of the bacterial phyla in males. (E) Composition of the bacterial phyla in females. (F) Comparison of caecal microbiota was performed with LDA effect size (LEfSe). The red area indicates the over-abundance in Pxr-/- male microbiota where the green area indicated the over-abundance in Pxr+/+ male microbiota. (G) Comparison of caecal microbiota was performed with LDA effect size (LEfSe). The red area indicates the over-abundance in Pxr-/- female microbiota where the green area indicated the over-abundance in Pxr+/+ female microbiota. (H) Relative abundances of some bacterial genera identified as significantly different between groups using LEfSe analysis. * = Significantly different (p

Published
2021
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27. The brlA Gene Deletion Reveals That Patulin Biosynthesis Is Not Related to Conidiation in Penicillium expansum

Author

Zetina-Serrano, Chrystian, Rocher, Ophélie, Naylies, Claire, Lippi, Yannick, Oswald, Isabelle P., Lorber, Sophie, Puel, Olivier, Biosynthèse & Toxicité des Mycotoxines (ToxAlim-BioToMyc), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Transcriptomic impact of Xenobiotics (E23 TRiX), Plateforme Génome & Transcriptome (GET), Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-ToxAlim (ToxAlim), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), ANR-17-CE21-0008,PATRISK,REDUCTION DU RISQUE PATULINE GRACE A UNE GESTION INTEGREE ET DURABLE DE LA PRODUCTION DE POMME ET DE PRODUITS DERIVES(2017), and Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3)

Subjects
animal structures, Genes, Fungal, Article, Indole Alkaloids, Fungal Proteins, lcsh:Chemistry, synnemata, Gene Expression Regulation, Fungal, Penicillium expansum, lcsh:QH301-705.5, patulin, [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, secondary metabolism, brlA, communesins, chaetoglobosins, fungi, Penicillium, food and beverages, conidiogenesis, metabolomics, Biosynthetic Pathways, Up-Regulation, lcsh:Biology (General), lcsh:QD1-999, Fruit, Malus, Multigene Family, Metabolome, Transcriptome, microarray, Gene Deletion
Abstract

Dissemination and survival of ascomycetes is through asexual spores. The brlA gene encodes a C2H2-type zinc-finger transcription factor, which is essential for asexual development. Penicillium expansum causes blue mold disease and is the main source of patulin, a mycotoxin that contaminates apple-based food. A P. expansum Pe&Delta, brlA deficient strain was generated by homologous recombination. In vivo, suppression of brlA completely blocked the development of conidiophores that takes place after the formation of coremia/synnemata, a required step for the perforation of the apple epicarp. Metabolome analysis displayed that patulin production was enhanced by brlA suppression, explaining a higher in vivo aggressiveness compared to the wild type (WT) strain. No patulin was detected in the synnemata, suggesting that patulin biosynthesis stopped when the fungus exited the apple. In vitro transcriptome analysis of Pe&Delta, brlA unveiled an up-regulated biosynthetic gene cluster (PEXP_073960-PEXP_074060) that shares high similarity with the chaetoglobosin gene cluster of Chaetomium globosum. Metabolome analysis of Pe&Delta, brlA confirmed these observations by unveiling a greater diversity of chaetoglobosin derivatives. We observed that chaetoglobosins A and C were found only in the synnemata, located outside of the apple, whereas other chaetoglobosins were detected in apple flesh, suggesting a spatial-temporal organization of the chaetoglobosin biosynthesis pathway.

Published
2020
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28. The GMO90+ Project: Absence of Evidence for Biologically Meaningful Effects of Genetically Modified Maize-based Diets on Wistar Rats After 6-Months Feeding Comparative Trial

Author

Coumoul, Xavier, Servien, Rémi, Juricek, Ludmila, Kaddouch-Amar, Yael, Lippi, Yannick, Berthelot, Laureline, Naylies, Claire, Morvan, Marie-Line, Antignac, Jean-Philippe, Desdoits-Lethimonier, Christèle, Jégou, Bernard, Tremblay-Franco, Marie, Canlet, Cécile, Debrauwer, Laurent, Le Gall, Caroline, Laurent, Julie, Gouraud, Pierre-Antoine, Cravedi, Jean Pierre, Jeunesse, Élisabeth, Savy, Nicolas, Dandere-Abdoulkarim, Kadidiatou, Arnich, Nathalie, Fourès, Franck, Cotton, Jérôme, Broudin, Simon, Corman, Bruno, Moing, Annick, Laporte, Bérengère, RICHARD-FORGET, Florence, Barouki, Robert, Rogowsky, Peter, Salles, Bernard, Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire (T3S - UMR_S 1124), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Laboratoire de Génétique Cellulaire (LGC), Ecole Nationale Vétérinaire de Toulouse (ENVT), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes (GERHM), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-IFR140-Institut National de la Santé et de la Recherche Médicale (INSERM), Xénobiotiques, MethodOmics [Toulouse] (Recherche-Développement en Biotechnologie), Methodomics, Laboratoire de sécurité des aliments de Maisons-Alfort, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Profilomic, Biologie du fruit et pathologie (BFP), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1, MycSA, Institut National de la Recherche Agronomique (INRA), CHU Necker - Enfants Malades [AP-HP], Reproduction et développement des plantes (RDP), École normale supérieure - Lyon (ENS Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Institut de pharmacologie et de biologie structurale (IPBS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Coumoul, Xavier, Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Transcriptomic impact of Xenobiotics (E23 TRiX), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Plateforme Génome & Transcriptome (GET), Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Analyse de Xénobiotiques, Identification, Métabolisme (E20 Metatoul-AXIOM), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-MetaboHUB-MetaToul, Direction de l'Evaluation des Risques (DER), Profilomic [Boulogne-Billancourt], Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1 (UB), Unité de recherche Mycologie et Sécurité des Aliments (MycSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Ecole d'Ingénieurs de Purpan (INP - PURPAN), Université de Toulouse (UT)-Université de Toulouse (UT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Plateforme Génome & Transcriptome (GET), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), MetaToul AXIOM (E20), Université de Toulouse (UT)-Université de Toulouse (UT)-MetaboHUB-MetaToul, MetaboHUB-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-MetaboHUB-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), École normale supérieure de Lyon (ENS de Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5), Université Sorbonne Paris Cité (USPC), Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UPS), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Centre de recherche sur l'Inflammation (CRI), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), École des Hautes Études en Santé Publique [EHESP] (EHESP), Institut de recherche, santé, environnement et travail (Irset), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), Institut de Mathématiques de Toulouse UMR5219 (IMT), Université Toulouse 1 Capitole (UT1)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UPS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-PRES Université de Toulouse-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), ANSES - Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Recherche Agronomique (INRA)-École normale supérieure - Lyon (ENS Lyon), Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-MetaToul-MetaboHUB, Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Plateforme Génome & Transcriptome (GET), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-MetaToul-MetaboHUB, Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), and Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDE] Environmental Sciences, genetically modified maize, OECD TG408, Male, [SDV]Life Sciences [q-bio], Food, Genetically Modified, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], [SDV.TOX.TCA]Life Sciences [q-bio]/Toxicology/Toxicology and food chain, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Zea mays, MON810, transcriptomics, [SDV.CAN] Life Sciences [q-bio]/Cancer, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Toxicity Tests, [SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], [SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health, Animals, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Rats, Wistar, [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], ComputingMilieux_MISCELLANEOUS, 6-month rat feeding trial, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Plants, Genetically Modified, [SDE.ES]Environmental Sciences/Environmental and Society, metabolomics, Animal Feed, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], NK603, Rats, [SDV.TOX] Life Sciences [q-bio]/Toxicology, [SDV.TOX.TCA] Life Sciences [q-bio]/Toxicology/Toxicology and food chain, Consumer Product Safety, [SDV.TOX]Life Sciences [q-bio]/Toxicology, [SDE]Environmental Sciences, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Safety Study of Gmo Maize, Female, [SDE.ES] Environmental Sciences/Environmental and Society, Edible Grain
Abstract

International audience; The GMO90+ project was designed to identify biomarkers of exposure or health effects in Wistar Han RCC rats exposed in their diet to 2 genetically modified plants (GMP) and assess additional information with the use of metabolomic and transcriptomic techniques. Rats were fed for 6-months with 8 maize-based diets at 33% that comprised either MON810 (11% and 33%) or NK603 grains (11% and 33% with or without glyphosate treatment) or their corresponding near-isogenic controls. Extensive chemical and targeted analyses undertaken to assess each diet demonstrated that they could be used for the feeding trial. Rats were necropsied after 3 and 6 months. Based on the Organization for Economic Cooperation and Development test guideline 408, the parameters tested showed a limited number of significant differences in pairwise comparisons, very few concerning GMP versus non-GMP. In such cases, no biological relevance could be established owing to the absence of difference in biologically linked variables, dose-response effects, or clinical disorders. No alteration of the reproduction function and kidney physiology was found. Metabolomics analyses on fluids (blood, urine) were performed after 3, 4.5, and 6 months. Transcriptomics analyses on organs (liver, kidney) were performed after 3 and 6 months. Again, among the significant differences in pairwise comparisons, no GMP effect was observed in contrast to that of maize variety and culture site. Indeed, based on transcriptomic and metabolomic data, we could differentiate MON- to NK-based diets. In conclusion, using this experimental design, no biomarkers of adverse health effect could be attributed to the consumption of GMP diets in comparison with the consumption of their near-isogenic non-GMP controls.

Published
2018
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29. Statistical Integration of ‘Omics Data Increases Biological Knowledge Extracted from Metabolomics Data: Application to Intestinal Exposure to the Mycotoxin Deoxynivalenol

Author

Tremblay-Franco, Marie, primary, Canlet, Cécile, additional, Pinton, Philippe, additional, Lippi, Yannick, additional, Gautier, Roselyne, additional, Naylies, Claire, additional, Neves, Manon, additional, Oswald, Isabelle P., additional, Debrauwer, Laurent, additional, and Alassane-Kpembi, Imourana, additional

Published
2021
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30. Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug target

Author

Smati, Sarra, primary, Polizzi, Arnaud, additional, Fougerat, Anne, additional, Ellero-Simatos, Sandrine, additional, Blum, Yuna, additional, Lippi, Yannick, additional, Régnier, Marion, additional, Laroyenne, Alexia, additional, Huillet, Marine, additional, Arif, Muhammad, additional, Zhang, Cheng, additional, Lasserre, Frederic, additional, Marrot, Alain, additional, Al Saati, Talal, additional, Wan, JingHong, additional, Sommer, Caroline, additional, Naylies, Claire, additional, Batut, Aurelie, additional, Lukowicz, Celine, additional, Fougeray, Tiffany, additional, Tramunt, Blandine, additional, Dubot, Patricia, additional, Smith, Lorraine, additional, Bertrand-Michel, Justine, additional, Hennuyer, Nathalie, additional, Pradere, Jean-Philippe, additional, Staels, Bart, additional, Burcelin, Remy, additional, Lenfant, Françoise, additional, Arnal, Jean-François, additional, Levade, Thierry, additional, Gamet-Payrastre, Laurence, additional, Lagarrigue, Sandrine, additional, Loiseau, Nicolas, additional, Lotersztajn, Sophie, additional, Postic, Catherine, additional, Wahli, Walter, additional, Bureau, Christophe, additional, Guillaume, Maeva, additional, Mardinoglu, Adil, additional, Montagner, Alexandra, additional, Gourdy, Pierre, additional, and Guillou, Hervé, additional

Published
2021
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32. The hepatocyte insulin receptor is required to program rhythmic gene expression and the liver clock

Author

Fougeray, Tiffany, primary, Polizzi, Arnaud, additional, Régnier, Marion, additional, Fougerat, Anne, additional, Ellero-Simatos, Sandrine, additional, Lippi, Yannick, additional, Smati, Sarra, additional, Lasserre, Frédéric, additional, Tramunt, Blandine, additional, Huillet, Marine, additional, Dopavogui, Léonie, additional, Smith, Lorraine, additional, Naylies, Claire, additional, Sommer, Caroline, additional, Benani, Alexandre, additional, Haas, Joel T., additional, Wahli, Walter, additional, Duez, Hélène, additional, Gourdy, Pierre, additional, Gamet-Payrastre, Laurence, additional, Burnol, Anne-Françoise, additional, Loiseau, Nicolas, additional, Postic, Catherine, additional, Montagner, Alexandra, additional, and Guillou, Hervé, additional

Published
2021
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34. Hepatocyte-specific deletion of Pparα promotes NAFLD in the context of obesity

Author

Régnier, Marion, primary, Polizzi, Arnaud, additional, Smati, Sarra, additional, Lukowicz, Céline, additional, Fougerat, Anne, additional, Lippi, Yannick, additional, Fouché, Edwin, additional, Lasserre, Frédéric, additional, Naylies, Claire, additional, Bétoulières, Colette, additional, Barquissau, Valentin, additional, Mouisel, Etienne, additional, Bertrand-Michel, Justine, additional, Batut, Aurélie, additional, Saati, Talal Al, additional, Canlet, Cécile, additional, Tremblay-Franco, Marie, additional, Ellero-Simatos, Sandrine, additional, Langin, Dominique, additional, Postic, Catherine, additional, Wahli, Walter, additional, Loiseau, Nicolas, additional, Guillou, Hervé, additional, and Montagner, Alexandra, additional

Published
2020
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35. Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug target.

Author

Smati, Sarra, Polizzi, Arnaud, Fougerat, Anne, Ellero-Simatos, Sandrine, Blum, Yuna, Lippi, Yannick, Régnier, Marion, Laroyenne, Alexia, Huillet, Marine, Arif, Muhammad, Cheng Zhang, Lasserre, Frederic, Marrot, Alain, Al Saati, Talal, JingHong Wan, Sommer, Caroline, Naylies, Claire, Batut, Aurelie, Lukowicz, Celine, and Fougeray, Tiffany

Subjects
FATTY liver, CHOLESTEROL content of food, NON-alcoholic fatty liver disease, ELLAGIC acid, DRUG target, SEXUAL dimorphism, LABORATORY mice, NF-kappa B
Published
2022
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36. Sex dimorphic role of estrogen receptor a in physiological regulation of hepatic metabolism

Author

Tramunt, Blandine, SMATI, Sarra, Grandgeorge, Naia, Fougerat, Anne, Guillaume, Maxime, Arnal, Jean-François, Naylies, Claire, Lippi, Yannick, Guillou, Hervé, Montagner, Alexandra, Gourdy, Pierre, ProdInra, Migration, CHU Toulouse [Toulouse], Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), ToxAlim (ToxAlim), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Toxicologie Intégrative & Métabolisme (ToxAlim-TIM), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Transcriptomic impact of Xenobiotics (E23 TRiX), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Plateforme Génome & Transcriptome (GET), Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Plateforme Génome & Transcriptome (GET), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
[SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

37. Gene Expression Profiling Reveals that PXR Activation Inhibits Hepatic PPARα Activity and Decreases FGF21 Secretion in Male C57Bl6/J Mice

Author

Barretto, Sharon Ann, primary, Lasserre, Frédéric, additional, Fougerat, Anne, additional, Smith, Lorraine, additional, Fougeray, Tiffany, additional, Lukowicz, Céline, additional, Polizzi, Arnaud, additional, Smati, Sarra, additional, Régnier, Marion, additional, Naylies, Claire, additional, Bétoulières, Colette, additional, Lippi, Yannick, additional, Guillou, Hervé, additional, Loiseau, Nicolas, additional, Gamet-Payrastre, Laurence, additional, Mselli-Lakhal, Laila, additional, and Ellero-Simatos, Sandrine, additional

Published
2019
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39. Impact of veA on the development, aggressiveness, dissemination and secondary metabolism of Penicillium expansum

Author

El Hajj Assaf, Christelle, Snini, Selma, Tadrist, Souria, Bally, Sylviane, Naylies, Claire, Oswald, Isabelle P., Lorber, Sophie, Puel, Olivier, Flanders Research Institute for agriculture, fisheries and food - ILVO (BELGIUM), Institut National Polytechnique de Toulouse - INPT (FRANCE), Institut National de la Recherche Agronomique - INRA (FRANCE), Université Toulouse III - Paul Sabatier - UT3 (FRANCE), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Flanders Research Institute for Agriculture, Fisheries and Food (ILVO), Research Institute for Agricultural, Fisheries and Food (ILVO), Transcriptomic impact of Xenobiotics (E23 TRiX), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Plateforme Génome & Transcriptome (GET), Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Biosynthèse & Toxicité des Mycotoxines (ToxAlim-BioToMyc), CASDAR AAP RT 2015 under Grant 1508 and by French National Research Agency under Grant ANR-17-CE21-0008 PATRISK, Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Plateforme Génome & Transcriptome (GET), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)

Subjects
Patulin, Apples, Penicilium expansum, food and beverages, Pathogenicity, Biologie cellulaire, Original Articles, Secondary metabolism, veA, [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, [SDV.BV.PEP]Life Sciences [q-bio]/Vegetal Biology/Phytopathology and phytopharmacy, Citrinin
Abstract

International audience; Penicillium expansum, the causal agent of blue mould disease, produces the mycotoxins patulin and citrinin amongst other secondary metabolites. Secondary metabolism is associated with fungal development, which responds to numerous biotic and abiotic external triggers. The global transcription factor VeA plays a key role in the coordination of secondary metabolism and differentiation processes in many fungal species. The specific role of VeA in P. expansum remains unknown. A null mutant PeΔveA strain and a complemented PeΔveA:veA strain were generated in P. expansum and their pathogenicity on apples was studied. Like the wild‐type and the complemented strains, the null mutant PeΔveA strain was still able to sporulate and to colonize apples, but at a lower rate. However, it could not form coremia either in vitro or in vivo, thus limiting its dissemination from natural substrates. The impact of veA on the expression of genes encoding proteins involved in the production of patulin, citrinin and other secondary metabolites was evaluated. The disruption of veA drastically reduced the production of patulin and citrinin on synthetic media, associated with a marked down‐regulation of all genes involved in the biosynthesis of the two mycotoxins. Moreover, the null mutant PeΔveA strain was unable to produce patulin on apples. The analysis of gene expression revealed a global impact on secondary metabolism, as 15 of 35 backbone genes showed differential regulation on two different media. These findings support the hypothesis that VeA contributes to the pathogenicity of P. expansum and modulates its secondary metabolism.

Published
2018
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40. Metabolic Effects of a Chronic Dietary Exposure to a Low-Dose Pesticide Cocktail in Mice: Sexual Dimorphism and Role of the Constitutive Androstane Receptor

Author

Lukowicz, Celine, Ellero-Simatos, Sandrine, Regnier, Marion, Polizzi, Arnaud, Lasserre, Frederic, Montagner, Alexandra, Lippi, Yannick, Jamin, Emilien L., Martin, Jean- Francois, Naylies, Claire, Canle, Cecile, Debrauwer, Laurent, Bertrand-Michel, Justine, Saati, Talal Al, Theodorou, Vassilia, Loiseau, Nicolas, Mselli-Lakhal, Laila, Guillou, Herve, and Gamet-Payrastre, Laurence

Subjects
European Union. European Food Safety Authority, Care and treatment, Usage, Research, Genetic aspects, Health aspects, Metabolites -- Research, Metabolic diseases -- Genetic aspects -- Care and treatment -- Research, Liquid chromatography -- Usage, Body weight -- Physiological aspects -- Health aspects, Mass spectrometry -- Usage
Abstract

Introduction The rates of metabolic disorders, including obesity and its complications, such as type 2 diabetes (T2D) and nonalcoholic fatty liver disease (NAFLD), have increased dramatically over the past three [...], BACKGROUND: Epidemiological evidence suggests a link between pesticide exposure and the development of metabolic diseases. However, most experimental studies have evaluated the metabolic effects of pesticides using individual molecules, often at nonrelevant doses or in combination with other risk factors such as high-fat diets. OBJECTIVES: We aimed to evaluate, in mice, the metabolic consequences of chronic dietary exposure to a pesticide mixture at nontoxic doses, relevant to consumers' risk assessment. METHODS: A mixture of six pesticides commonly used in France, i.e., boscalid, captan, chlorpyrifos, thiofanate, thiacloprid, and ziram, was incorporated in a standard chow at doses exposing mice to the tolerable daily intake (TDI) of each pesticide. Wild-type (WT) and constitutive androstane receptor-deficient ([CAR.sup.-/-]) male and female mice were exposed for 52 wk. We assessed metabolic parameters [body weight (BW), food and water consumption, glucose tolerance, urinary metabolome] throughout the experiment. At the end of the experiment, we evaluated liver metabolism (histology, transcriptomics, metabolomics, lipidomics) and pesticide detoxification using liquid chromatography-mass spectrometry (LC-MS). RESULTS: Compared to those fed control chow, WT male mice fed pesticide chow had greater BW gain and more adiposity. Moreover, these WT males fed pesticide chow exhibited characteristics of hepatic steatosis and glucose intolerance, which were not observed in those fed control chow. WT exposed female mice exhibited fasting hyperglycemia, higher reduced glutathione (GSH):oxidized glutathione (GSSG) liver ratio and perturbations of gut microbiota-related urinary metabolites compared to WT mice fed control chow. When we performed these experiments on [CAR.sup.-/-] mice, pesticide-exposed [CAR.sup.-/-] males did not exhibit BW gain or changes in glucose metabolism compared to the [CAR.sup.-/-] males fed control chow. Moreover, [CAR.sup.-/-] females fed pesticide chow exhibited pesticide toxicity with higher BWs and mortality rate compared to the [CAR.sup.-/-] females fed control chow. CONCLUSIONS: To our knowledge, we are the first to demonstrate a sexually dimorphic obesogenic and diabetogenic effect of chronic dietary exposure to a common mixture of pesticides at TDI levels, and to provide evidence for a partial role for CAR in an in vivo mouse model. This raises questions about the relevance of TDI for individual pesticides when present in a mixture. https://doi.org/10.1289/EHP2877

Published
2018
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41. Hepatocyte-specific deletion of Pparα promotes NASH in the context of obesity

Author

Régnier, Marion, primary, Polizzi, Arnaud, additional, Smati, Sarra, additional, Lukowicz, Céline, additional, Fougerat, Anne, additional, Lippi, Yannick, additional, Fouché, Edwin, additional, Lasserre, Frédéric, additional, Naylies, Claire, additional, Bétoulières, Colette, additional, Barquissau, Valentin, additional, Mouisel, Etienne, additional, Bertrand-Michel, Justine, additional, Batut, Aurélie, additional, Saati, Talal Al, additional, Canlet, Cécile, additional, Tremblay-Franco, Marie, additional, Ellero-Simatos, Sandrine, additional, Langin, Dominique, additional, Postic, Catherine, additional, Wahli, Walter, additional, Loiseau, Nicolas, additional, Guillou, Hervé, additional, and Montagner, Alexandra, additional

Published
2018
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42. The protective role of liver X receptor (LXR) during fumonisin B1-induced hepatotoxicity

Author

Régnier, Marion, primary, Polizzi, Arnaud, additional, Lukowicz, Céline, additional, Smati, Sarra, additional, Lasserre, Frédéric, additional, Lippi, Yannick, additional, Naylies, Claire, additional, Laffitte, Joelle, additional, Bétoulières, Colette, additional, Montagner, Alexandra, additional, Ducheix, Simon, additional, Gourbeyre, Pascal, additional, Ellero-Simatos, Sandrine, additional, Menard, Sandrine, additional, Bertrand-Michel, Justine, additional, Al Saati, Talal, additional, Lobaccaro, Jean-Marc, additional, Burger, Hester M., additional, Gelderblom, Wentzel C., additional, Guillou, Hervé, additional, Oswald, Isabelle P., additional, and Loiseau, Nicolas, additional

Published
2018
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44. Time course study of the response to LPS targeting the pig immune gene networks

Author

Terenina, Elena, primary, Sautron, Valérie, additional, Ydier, Caroline, additional, Bazovkina, Darya, additional, Sevin-Pujol, Amélie, additional, Gress, Laure, additional, Lippi, Yannick, additional, Naylies, Claire, additional, Billon, Yvon, additional, Liaubet, Laurence, additional, Mormede, Pierre, additional, and Villa-Vialaneix, Nathalie, additional

Published
2017
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45. Intestinal toxicity of the type B trichothecene mycotoxin fusarenon-X: whole transcriptome profiling reveals new signaling pathways

Author

Alassane-Kpembi, Imourana, primary, Gerez, Juliana Rubira, additional, Cossalter, Anne-Marie, additional, Neves, Manon, additional, Laffitte, Joëlle, additional, Naylies, Claire, additional, Lippi, Yannick, additional, Kolf-Clauw, Martine, additional, Bracarense, Ana Paula L., additional, Pinton, Philippe, additional, and Oswald, Isabelle P., additional

Published
2017
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46. The GMO90+ Project: Absence of Evidence for Biologically Meaningful Effects of Genetically Modified Maize-based Diets on Wistar Rats After 6-Months Feeding Comparative Trial.

Author

Coumoul, Xavier, Servien, Rémi, Juricek, Ludmila, Kaddouch-Amar, Yael, Lippi, Yannick, Berthelot, Laureline, Naylies, Claire, Morvan, Marie-Line, Antignac, Jean-Philippe, Desdoits-Lethimonier, Christèle, Jegou, Bernard, Tremblay-Franco, Marie, Canlet, Cécile, Debrauwer, Laurent, Gall, Caroline Le, Laurent, Julie, Gouraud, Pierre-Antoine, Cravedi, Jean-Pierre, Jeunesse, Elisabeth, and Savy, Nicolas

Subjects
TRANSGENIC plants, ANIMAL feeding, KIDNEY physiology, RATS, INTERNATIONAL economic relations
Abstract

The GMO90+ project was designed to identify biomarkers of exposure or health effects in Wistar Han RCC rats exposed in their diet to 2 genetically modified plants (GMP) and assess additional information with the use of metabolomic and transcriptomic techniques. Rats were fed for 6-months with 8 maize-based diets at 33% that comprised either MON810 (11% and 33%) or NK603 grains (11% and 33% with or without glyphosate treatment) or their corresponding near-isogenic controls. Extensive chemical and targeted analyses undertaken to assess each diet demonstrated that they could be used for the feeding trial. Rats were necropsied after 3 and 6 months. Based on the Organization for Economic Cooperation and Development test guideline 408, the parameters tested showed a limited number of significant differences in pairwise comparisons, very few concerning GMP versus non-GMP. In such cases, no biological relevance could be established owing to the absence of difference in biologically linked variables, dose-response effects, or clinical disorders. No alteration of the reproduction function and kidney physiology was found. Metabolomics analyses on fluids (blood, urine) were performed after 3, 4.5, and 6 months. Transcriptomics analyses on organs (liver, kidney) were performed after 3 and 6 months. Again, among the significant differences in pairwise comparisons, no GMP effect was observed in contrast to that of maize variety and culture site. Indeed, based on transcriptomic and metabolomic data, we could differentiate MON- to NK-based diets. In conclusion, using this experimental design, no biomarkers of adverse health effect could be attributed to the consumption of GMP diets in comparison with the consumption of their near-isogenic non-GMP controls. [ABSTRACT FROM AUTHOR]

Published
2019
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47. Identification des fonctions physiologiques de PPARbeta hépatocytaire : rôle possible dans le diabète de type 2

Author

Montagner, Alexandra, primary, Michel, Géraldine, additional, Fouché, Edwin, additional, Régnier, Marion, additional, Polizzi, Arnaud, additional, Lukowicz, Céline, additional, Amiel, Aurélien, additional, Lasserre, Frédéric, additional, Naylies, Claire, additional, Canlet, Cécile, additional, Tremblay-Franco, Marie, additional, Debrauwer, Laurent, additional, Wahli, Walter, additional, and Guillou, Hervé, additional

Published
2017
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49. The GeT-TRiX facility: automated processing of expression microarrays - from samples to data analysis reports

Author

Lippi, Yannick, Naylies, Claire, Martin, Pascal G.P., Transcriptomic impact of Xenobiotics (E23 TRiX), ToxAlim (ToxAlim), Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Plateforme Génome & Transcriptome (GET), Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2014

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