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2. Sphingolipid

Author

Nosheen, Shaista, primary, Naz, Tahira, additional, Nazir, Yusuf, additional, and Song, Yuanda, additional

Published
2023
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10. Microalgae single cell oil

Author

Nazir, Yusuf, primary, Halim, Hafiy, additional, Prabhakaran, Pranesha, additional, Hamid, Aidil Abdul, additional, and Song, Yuanda, additional

Published
2020
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11. Contributors

Author

Abdelkafi, Slim, primary, Acquah, Caleb, additional, Almeida, Cíntia Jesus, additional, de Almeida Cezare-Gomes, Eleane, additional, Amaro, Helena Melo, additional, Baby, André Rolim, additional, Bassi, Amarjeet, additional, Bi, Zheting, additional, Bridiau, Nicolas, additional, Cañizares-Villanueva, Rosa Olivia, additional, de Carvalho, João Carlos Monteiro, additional, Chisti, Yusuf, additional, Danquah, Michael Kobina, additional, Das, Debabrata, additional, Delattre, Cédric, additional, Deprá, Mariany Costa, additional, Dias, Rosangela Rodrigues, additional, Dubessay, Pascal, additional, El Alaoui, Hicham, additional, Esteves, Ana Filipa, additional, Estrada, Adrián, additional, Fagundes, Mariane Bittencourt, additional, Fendri, Imen, additional, Fernández, Francisco Gabriel Acién, additional, Fernández-Sevilla, José María, additional, Ferreira, Alice, additional, Gallo-García, Luis Alberto, additional, Gomez-Ochoa, Manuel, additional, Gonçalves, Ana Luísa, additional, Gonzalez-Diaz, Jose, additional, Gouveia, Luisa, additional, Grima, Emilio Molina, additional, Guedes, Ana Catarina, additional, Halim, Hafiy, additional, Hamid, Aidil Abdul, additional, He, Brian, additional, Hu, Yulin, additional, İnan, Benan, additional, Jacob-Lopes, Eduardo, additional, Jeevanandam, Jaison, additional, Joshi, Saurabh Milind, additional, Kafarov, Vyacheslav, additional, Kausley, Shankar Balajirao, additional, Koçer, Anıl Tevfik, additional, Koller, Martin, additional, Kumar, Arun, additional, Lourenço, Sergio de Oliveira, additional, Maroneze, Mariana Manzoni, additional, Martínez-Roldán, Alfredo de Jesús, additional, Maugard, Thierry, additional, Merchuk, Jose C., additional, Michaud, Philippe, additional, Morales, Marcia, additional, Morocho-Jácome, Ana Lucía, additional, Moya, Bernardo Llamas, additional, Nazir, Yusuf, additional, Norsker, Niels-Henrik, additional, Ojeda, Karina A., additional, Özçimen, Didem, additional, Özer, Tugba, additional, Pabbi, Sunil, additional, Pagels, Fernando, additional, Paludo, Luana Cristina, additional, Pan, Sharadwata, additional, Pandit, Aniruddha Bhalchandra, additional, Patil, Rajshree Amrut, additional, Peron-Schlosser, Bianca, additional, Pierre, Guillaume, additional, Pinheiro, Pricila Nass, additional, Pires, José Carlos, additional, Prabhakaran, Pranesha, additional, Prakash, Anil, additional, Prybylski, Nastasia, additional, Queiroz, Maria Isabel, additional, Reijnders, Lucas, additional, Rincón, Bárbara, additional, Rosado, Catarina, additional, Ruiz-Ruiz, Patricia, additional, Saini, Dinesh Kumar, additional, Salvaterra, Daniel, additional, Sánchez-Tuirán, Eduardo, additional, Sauce, Rafael, additional, Severo, Ihana Aguiar, additional, Shukla, Pratyoosh, additional, Singh, Harshita, additional, Singh, Jay Shankar, additional, Song, Yuanda, additional, Spier, Michele Rigon, additional, Tibbetts, Sean M., additional, Toucheteau, Claire, additional, Udenigwe, Chibuike, additional, Velasco, Maria Valéria Robles, additional, Vendruscolo, Raquel Guidetti, additional, Vieira, Juliana Guerra, additional, Vieira, Karem Rodrigues, additional, Vigani, Mauro, additional, Wagner, Roger, additional, Zanette, Cristina Maria, additional, and Zepka, Leila Queiroz, additional

Published
2020
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18. The Big Data Technology: Assessing the Impact in the Banking Industry

Author

Musa Ahmed Zayyad, Saadana Shehu, Alhassan Adamu, Shamsu Abdullahi, Nazir Yusuf, Abubakar Zakari, Lawal Idris Bagiwa, and Amina Nura

Subjects
Business information, Government, Process (engineering), business.industry, Big data, Business and Finance, General Medicine, Business, Commit, Private sector, Database transaction, Industrial organization
Abstract

Big data is a form of data with increased volume, difficult to analyze, process, and store using traditional database technologies. It has long been adopted in business and finance where a large number of bank transaction are executed daily. The emergence of big data in banking industry results to large proportion of technical improvements in the industry. However, its processing causes disruption in the banking industry. Big data analytics is the process that involves using algorithms and software tools to extract useful business information from the dataset. This study adopts big data analytics process to investigates the disruption due to big data processing in the banking industry. The study identifies, acquired, and extracted dataset of the banking industry which was analyzed using MapReduce based fraud committed due to processing of large amount of data. findings show that government employee commit more crime in comparison with the private sector employees. Finally, based on customers gender, the male employees commit most of the fraud in both government and private sector.

Published
2020
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23. Genetic Modification of Mucor circinelloides for Canthaxanthin Production by Heterologous Expression of β-carotene Ketolase Gene

Author

Naz, Tahira, primary, Yang, Junhuan, additional, Nosheen, Shaista, additional, Sun, Caili, additional, Nazir, Yusuf, additional, Mohamed, Hassan, additional, Fazili, Abu Bakr Ahmad, additional, Ullah, Samee, additional, Li, Shaoqi, additional, Yang, Wu, additional, Garre, Victoriano, additional, and Song, Yuanda, additional

Published
2021
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25. Additional file 1 of Role of Snf-β in lipid accumulation in the high lipid‐producing fungus Mucor circinelloides WJ11

Author

Nosheen, Shaista, Naz, Tahira, Junhuan Yang, Hussain, Syed Ammar, Fazili, Abu Bakr Ahmad, Nazir, Yusuf, Shaoqi Li, Mohamed, Hassan, Yang, Wu, Kiren Mustafa, and Song, Yuanda

Abstract

Additional file 1: Fig. S1. Cell growth and lipid content analysis of transformants and control strains at 96 h: a) cell dry weight (CDW) of wild type control (MU2075) and knockout transformant (MU1576 and MU1577), b) lipid content of MU2075, MU1576 and MU1577, c) cell dry weight (CDW) of wild type control (MU2075), strain with empty pMAT2075 plasmid (Mc2075) and overexpressing transformant (Mc3075, Mc3076, Mc3077) d) lipid content of MU2075, Mc2075 Mc3075, Mc3076, Mc3077. Error bars represent standard deviations (n = 3). Table S1. Primer sequences used in this study.

Published
2021
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26. Deletion of plasma membrane malate transporters increased lipid accumulation in the oleaginous fungus mucor circinelloides WJ11

Author

National Natural Science Foundation of China, Shandong University, Ministerio de Educación, Cultura y Deporte (España), Yang, Junhuan, Cánovas-Márquez, José T., Li, Pengcheng, Li, Shaoqi, Niu, Junchao, Wang, Xiuwen, Nazir, Yusuf, López-García, Sergio, Garre, Victoriano, Song, Yuanda, National Natural Science Foundation of China, Shandong University, Ministerio de Educación, Cultura y Deporte (España), Yang, Junhuan, Cánovas-Márquez, José T., Li, Pengcheng, Li, Shaoqi, Niu, Junchao, Wang, Xiuwen, Nazir, Yusuf, López-García, Sergio, Garre, Victoriano, and Song, Yuanda

Abstract

Malate as an important intermediate metabolite, its subcellular location, and concentration have a significant impact on fungal lipid metabolism. Previous studies showed that the mitochondrial malate transporter plays an important role in lipid accumulation in Mucor circinelloides by manipulating intracellular malate concentration. However, the role of plasma membrane malate transporters in oleaginous fungi remains unexplored. Therefore, in this work, two plasma membrane malate transporters "2-oxoglutarate:malate antiporters" (named SoDIT-a and SoDIT-b) of M. circinelloides WJ11 were deleted, and the consequences in growth capacity, lipid accumulation, and metabolism were analyzed. The results showed that deletion of sodit-a or/and sodit-b reduced the extracellular malate, confirming that the products of both genes participate in malate transportation. In parallel, the lipid contents in mutants increased approximately 10-40% higher than that in the control strain, suggesting that the defect in plasma membrane malate transport results in an increase of malate available for lipid biosynthesis. Furthermore, transcriptional analysis showed that the expression levels of multiple key genes involved in the lipid biosynthesis were also increased in the knockout mutants. To the best of our knowledge, this is the first report that demonstrated the association between plasma membrane malate transporters and lipid accumulation in M. circinelloides.

Published
2021

29. Screening, characterization, and in vitro-ROS dependent cytotoxic potential of extract from Ficus carica against hepatocellular (HepG2) carcinoma cells

Author

Mustafa, Kiren, primary, Yu, Shaoxuan, additional, Zhang, Wen, additional, Mohamed, Hassan, additional, Naz, Tahira, additional, Xiao, Haifang, additional, Liu, Yingxin, additional, Nazir, Yusuf, additional, Fazili, Abu Bakr Ahmad, additional, Nosheen, Shaista, additional, Bai, Xueyuan, additional, and Song, Yuanda, additional

Published
2021
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33. Different Classes of Phytohormones Act Synergistically to Enhance the Growth, Lipid and DHA Biosynthetic Capacity of Aurantiochytrium sp. SW1

Author

Nazir, Yusuf, primary, Halim, Hafiy, additional, Prabhakaran, Pranesha, additional, Ren, Xiaojie, additional, Naz, Tahira, additional, Mohamed, Hassan, additional, Nosheen, Shaista, additional, Mustafa, Kiren, additional, Yang, Wu, additional, Abdul Hamid, Aidil, additional, and Song, Yuanda, additional

Published
2020
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38. Probiotics and Their Potential Preventive and Therapeutic Role for Cancer, High Serum Cholesterol, and Allergic and HIV Diseases

Author

Nazir, Yusuf, Hussain, Syed Ammar, Abdul Hamid, Aidil, and Song, Yuanda

Subjects
Article Subject
Abstract

The potential health benefits of probiotics have long been elucidated since Metchnikoff and his coworkers postulated the association of probiotic consumption on human’s health and longevity. Since then, many scientific findings and research have further established the correlation of probiotic and gut-associated diseases such as irritable bowel disease and chronic and antibiotic-associated diarrhea. However, the beneficial impact of probiotic is not limited to the gut-associated diseases alone, but also in different acute and chronic infectious diseases. This is due to the fact that probiotics are able to modify the intestinal microbial ecosystem, enhance the gut barrier function, provide competitive adherence to the mucosa and epithelium, produce antimicrobial substances, and modulate the immune activity by enhancing the innate and adaptive immune response. Nevertheless, the current literature with respect to the association of probiotic and cancer, high serum cholesterol, and allergic and HIV diseases are still scarce and controversial. Therefore, in the present work, we reviewed the potential preventive and therapeutic role of probiotics for cancer, high serum cholesterol, and allergic and HIV diseases as well as providing its possible mechanism of actions.

Published
2018
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42. Optimization of Diverse Carbon Sources and Cultivation Conditions for Enhanced Growth and Lipid and Medium-Chain Fatty Acid (MCFA) Production by Mucor circinelloides.

Author

Hussain, Syed Ammar, Nazir, Yusuf, Hameed, Ahsan, Wu Yang, Mustafa, Kiren, and Yuanda Song

Subjects
FATTY acids, MUCOR, LIPIDS, MICROBIAL lipids, CARBON, COCONUT oil
Abstract

The effects of various carbon sources and cultivation conditions on the growth kinetics, lipid accumulation, and medium-chain fatty acid (MCFA) production of Mucor circinelloides (MC) was investigated for 72 h in shake flask cultivation. Our previous investigation reported increments of 28 to 46% MCFAs among total cell lipids when the MC genome was genetically modified, in comparison to the wild-type. However, the growth of the engineered strain M65-TE-04 was adversely affected. Therefore, the current study was designed to enhance the growth, lipid production, and MCFA productivity of engineered M. circinelloides by optimizing the pH, agitation speed, temperature, and carbon sources. The findings for individual variables disclosed that the highest biomass (17.0 g/L) was obtained when coconut oil mixed with glucose was used as a carbon source under normal culture conditions. Additionally, the maximum lipid contents (67.5% cell dry weight (CDW)), MCFA contents (53% total fatty acid (TFA)), and overall lipid productivity (3.53 g/L•d) were attained at 26 °C, pH 6.0, and 150 rpm, respectively. The maximum biomass (19.4 g/L), TFA (14.3g/L), and MCFA (4.71 g/L) contents were achieved with integration of a temperature of 26 °C, pH 6.0, agitation speed 300 rpm, and coconut oil mixed medium as the carbon source. This work illustrates that biomass, TFA, and MCFA contents were increased 1.70-2.0-fold by optimizing the initial pH, agitation speed, temperature, and carbon sources in the M. circinelloides engineered strain (M65-TE-04) in comparison to initial cultivation conditions. [ABSTRACT FROM AUTHOR]

Published
2019
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