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5 results on '"Nazukin, A. S."'

2. Toxicity of monazite particulates and its attenuation with a complex of bio-protectors.

Author

Katsnelson BA, Yeremenko OS, Privalova LI, Makeyev OH, Degtyareva TD, Beresneva OY, Valamina IE, Minihaliyeva IA, Sutunkova MP, Kireyeva EP, Bukhantsev VA, Dovzenko EI, Minin VV, Kulikov ES, Kostykova SV, and Nazukin AS

Subjects
Animals, Antioxidants therapeutic use, Bronchoalveolar Lavage Fluid cytology, Drug Administration Routes, Drug Evaluation, Preclinical, Female, Fish Oils therapeutic use, Glutamic Acid therapeutic use, Iodine therapeutic use, Methionine therapeutic use, Minerals therapeutic use, Mutagenicity Tests, Particle Size, Pneumoconiosis prevention & control, Premedication, Rats, Thorium adverse effects, Trachea, Uranium adverse effects, Vitamins therapeutic use, Metals, Rare Earth toxicity, Particulate Matter toxicity, Pneumoconiosis etiology
Abstract

Background: Workers employed on mining, processing and storage of monazite are at risk of exposure to dust with expected adverse health effects., Objectives: To study the adverse health effects of monazite particles in experiments on rats and to test the possibility of attenuating these effects., Methods: Outbred white rats were injected intratracheally with a suspension of ground monazite concentrate (MC) in order to investigate the cellular response of the lower airways 24 hours later and the organism's status 6 months after the injection. The bio-protective complex (BPC) tested in these experiments consisted of glutamate, an iodine preparation, methionine, a polyvitamin-polymineral composition, and/or "Eicosavitol" (fish oil preparation rich in PUFA, predominantly of the omega 3-group). Bio-protectors were administered together with the rat food and drink daily for one month before the MC injection in the short-term experiment, or over 6 months after such injection in the long-term experiment., Results: MC induced manifestations of its cytotoxicity, fibrogenicity and systemic toxicity as well as genotoxicity. The tested BPC attenuated virtually all these effects. Although a similar protective potential of "Eicosavitol" against almost all of them was lower compared with that of BPC, combining BPC with "Eicosavitol" provided, as a rule, the greatest protective effect., Conclusion: It may be assumed that the many-sided adverse effects of MC on the organism is due, at least partially, to the presence in its composition of not only rare earth elements but also of natural radioisotopes of the thorium and uranium families. The combination of the bio-protectors tested was highly effective and may be recommended for administering in periodic preventive programmes to exposed workers.

Published
2009

4. [Effects of trivalent chromium on several processes of bioenergetics and adenyl nucleotide metabolism].

Author

Nazukin AS

Subjects
Alcohol Oxidoreductases metabolism, Alkaline Phosphatase metabolism, Amino Acid Oxidoreductases metabolism, Animals, Glutamate Dehydrogenase metabolism, L-Lactate Dehydrogenase metabolism, Malate Dehydrogenase metabolism, Rats, Succinate Dehydrogenase metabolism, Time Factors, Chromium pharmacology, Energy Metabolism drug effects, Enzymes metabolism
Published
1996

5. [Effect of small doses of molybdenum on bioenergetics and adenine nucleotide metabolism].

Author

Nazukin AS, Pestova LV, and Zaĭtseva EV

Subjects
Animals, Dose-Response Relationship, Drug, Models, Biological, Molybdenum administration & dosage, Rats, Time Factors, Adenine Nucleotides metabolism, Energy Metabolism drug effects, Molybdenum toxicity
Abstract

A mechanism of chronic molybdenum (Mo) intoxication development at doses 0.25 and 2.5 mg/kg is studied. Mo in these doses can change bioenergetic processes and adenine nucleotide metabolism. Criteria for early diagnosis of Mo effect on organism are suggested.

Published
1994

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