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We plan to measure several 2S-2P transition frequencies in μ[sup.4][He.sup.+] and μ³[He.sup.+] by means of laser spectroscopy with an accuracy of 50 ppm. This will lead to a determination of the corresponding nuclear rms charge radii with a relative accuracy of 3 x [10.sup.-4], limited by the uncertainty of the nuclear polarization contribution. First, these measurements will help to solve the proton radius puzzle. Second, these very precise nuclear radii are benchmarks for ab initio few- nucleon theories and potentials. Finally when combined with an ongoing measurement of the 1S-2S transition in [He.sup.+], these measurements will lead to an enhanced bound-state QED test of the 1S Lamb shift in [He.sup.+]. PACS Nos: 36.10.Ee, 31.30.J, 31.15.ag, 21.10.Ft, 21.45.V, 21.60.De, 14.20.Dh Nous prevoyons mesurer les frequences de plusieurs transitions 2S-2P dans μ[sup.4][He.sup.+] et μ³[He.sup.+] par spectroscopie laser visant une precision de 50 ppm. Ceci aidera a determiner le rayon rms correspondant des charges nucleeaires avec une precision relative de 3 x [10.sup.-4], limitee par l'incertitude sur la contribution de la polarisation nucleeaire. Dans un premier temps, ces mesures aideront a solutionner le casse-tete du rayon du proton. Ensuite, ces valeurs tres precises des rayons nucleaires sont des criteres pour tester les potentiels et les theories ab initio de probleme a quelques nucleeons. Finalement, lorsque combineees avec les mesures courantes de la transition 1S-2S dans [He.sup.+], ces mesures meneront a des tests ameliores de calculs QED en etats lieis pour le decalage de Lamb dans [He.sup.+]. [Traduit par la Redaction], 1. Hydrogen and muonic hydrogen Historically, the simple spectral structure of hydrogen (H) and 'hydrogen-like' atoms has inspired path-breaking discoveries like quantum mechanics, discovery of the electron spin, and quantum [...]

The measurement of the magnetic field in the tracking volume inside the superconducting coil of the Compact Muon Solenoid (CMS) detector under construction at CERN is done with a fieldmapper designed and produced at Fermilab. The results of the measurements made at 4 T are compared with a three-dimensional model of the CMS magnet system calculated with TOSCA.

Abstract: The Lamb-shift experiment in muonic hydrogen ([μ.sup.-]p) aims to measure the energy difference between the [2S.sup.F=1.sub.1/2] [-2P.sup.F=2.sub.3/2] atomic levels to a precision of 30 ppm. This would allow the [...]

We plan to measure several 2S-2P transition frequencies in μ4He+ and μ3He+ by means of laser spectroscopy with an accuracy of 50 ppm. This will lead to a determination of the corresponding nuclear rms charge radii with a relative accuracy of 3 × 10-4, limited by the uncertainty of the nuclear polarization contribution. First, these measurements will help to solve the proton radius puzzle. Second, these very precise nuclear radii are benchmarks for ab initio few-nucleon theories and potentials. Finally when combined with an ongoing measurement of the 1S-2S transition in He+, these measurements will lead to an enhanced bound-state QED test of the 1S Lamb shift in He+. Nous prévoyons mesurer les fréquences de plusieurs transitions 2S-2P dans μ4He+ et μ3He+ par spectroscopie laser visant une précision de 50 ppm. Ceci aidera à déterminer le rayon rms correspondant des charges nucléaires avec une précision relative de 3 × 10-4, limitée par l'incertitude sur la contribution de la polarisation nucléaire. Dans un premier temps, ces mesures aideront à solutionner le casse-tête du rayon du proton. Ensuite, ces valeurs très précises des rayons nucléaires sont des critères pour tester les potentiels et les théories ab initio de problème à quelques nucléons. Finalement, lorsque combinées avec les mesures courantes de la transition 1S-2S dans He+, ces mesures mèneront à des tests améliorés de calculs QED en états liés pour le décalage de Lamb dans He+. [ABSTRACT FROM AUTHOR]

One of the most challenging aspects of developing advanced cell therapy products (CTPs) is defining the mechanism of action (MOA), potency and efficacy of the product. This perspective examines these concepts and presents helpful ways to think about them through the lens of metrology. A logical framework for thinking about MOA, potency and efficacy is presented that is consistent with the existing regulatory guidelines, but also accommodates what has been learned from the 27 US FDA-approved CTPs. Available information regarding MOA, potency and efficacy for the 27 FDA-approved CTPs is reviewed to provide background and perspective. Potency process and efficacy process charts are introduced to clarify and illustrate the relationships between six key concepts: MOA, potency, potency test, efficacy, efficacy endpoint and efficacy endpoint test. Careful consideration of the meaning of these terms makes it easier to discuss the challenges of correlating potency test results with clinical outcomes and to understand how the relationships between the concepts can be misunderstood during development and clinical trials. Examples of how a product can be "potent but not efficacious" or "not potent but efficacious" are presented. Two example applications of the framework compare how MOA is assessed in cell cultures, animal models and human clinical trials and reveals the challenge of establishing MOA in humans. Lastly, important considerations for the development of potency tests for a CTP are discussed. These perspectives can help product developers set appropriate expectations for understanding a product's MOA and potency, avoid unrealistic assumptions and improve communication among team members during the development of CTPs., (© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)

The energy levels of hydrogen-like atomic systems can be calculated with great precision. Starting from their quantum mechanical solution, they have been refined over the years to include the electron spin, the relativistic and quantum field effects, and tiny energy shifts related to the complex structure of the nucleus. These energy shifts caused by the nuclear structure are vastly magnified in hydrogen-like systems formed by a negative muon and a nucleus, so spectroscopy of these muonic ions can be used to investigate the nuclear structure with high precision. Here we present the measurement of two 2S-2P transitions in the muonic helium-4 ion that yields a precise determination of the root-mean-square charge radius of the α particle of 1.67824(83) femtometres. This determination from atomic spectroscopy is in excellent agreement with the value from electron scattering 1 , but a factor of 4.8 more precise, providing a benchmark for few-nucleon theories, lattice quantum chromodynamics and electron scattering. This agreement also constrains several beyond-standard-model theories proposed to explain the proton-radius puzzle 2-5 , in line with recent determinations of the proton charge radius 6-9 , and establishes spectroscopy of light muonic atoms and ions as a precise tool for studies of nuclear properties.

The deuteron is the simplest compound nucleus, composed of one proton and one neutron. Deuteron properties such as the root-mean-square charge radius rd and the polarizability serve as important benchmarks for understanding the nuclear forces and structure. Muonic deuterium μd is the exotic atom formed by a deuteron and a negative muon μ(-). We measured three 2S-2P transitions in μd and obtain r(d) = 2.12562(78) fm, which is 2.7 times more accurate but 7.5σ smaller than the CODATA-2010 value r(d) = 2.1424(21) fm. The μd value is also 3.5σ smaller than the r(d) value from electronic deuterium spectroscopy. The smaller r(d), when combined with the electronic isotope shift, yields a "small" proton radius r(p), similar to the one from muonic hydrogen, amplifying the proton radius puzzle., (Copyright © 2016, American Association for the Advancement of Science.)

Avalanche photodiodes are commonly used as detectors for low energy x-rays. In this work, we report on a fitting technique used to account for different detector responses resulting from photoabsorption in the various avalanche photodiode layers. The use of this technique results in an improvement of the energy resolution at 8.2 keV by up to a factor of 2 and corrects the timing information by up to 25 ns to account for space dependent electron drift time. In addition, this waveform analysis is used for particle identification, e.g., to distinguish between x-rays and MeV electrons in our experiment.

A multipass laser cavity is presented which can be used to illuminate an elongated volume from a transverse direction. The illuminated volume can also have a very large transverse cross section. Convenient access to the illuminated volume is granted. The multipass cavity is very robust against misalignment, and no active stabilization is needed. The scheme is suitable for example in beam experiments, where the beam path must not be blocked by a laser mirror, or if the illuminated volume must be very large. This cavity was used for the muonic-hydrogen experiment in which 6 μm laser light illuminated a volume of 7 × 25 × 176 mm3, using mirrors that are only 12 mm in height. We present our measurement of the intensity distribution inside the multipass cavity and show that this is in good agreement with our simulation.

Accurate knowledge of the charge and Zemach radii of the proton is essential, not only for understanding its structure but also as input for tests of bound-state quantum electrodynamics and its predictions for the energy levels of hydrogen. These radii may be extracted from the laser spectroscopy of muonic hydrogen (μp, that is, a proton orbited by a muon). We measured the 2S(1/2)(F=0)-2P(3/2)(F=1) transition frequency in μp to be 54611.16(1.05) gigahertz (numbers in parentheses indicate one standard deviation of uncertainty) and reevaluated the 2S(1/2)(F=1)-2P(3/2)(F=2) transition frequency, yielding 49881.35(65) gigahertz. From the measurements, we determined the Zemach radius, r(Z) = 1.082(37) femtometers, and the magnetic radius, r(M) = 0.87(6) femtometer, of the proton. We also extracted the charge radius, r(E) = 0.84087(39) femtometer, with an order of magnitude more precision than the 2010-CODATA value and at 7σ variance with respect to it, thus reinforcing the proton radius puzzle.

It is now recognized that the International System of Units (SI units) will be redefined in terms of fundamental constants, even if the date when this will occur is still under debate. Actually, the best estimate of fundamental constant values is given by a least-squares adjustment, carried out under the auspices of the Committee on Data for Science and Technology (CODATA) Task Group on Fundamental Constants. This adjustment provides a significant measure of the correctness and overall consistency of the basic theories and experimental methods of physics using the values of the constants obtained from widely differing experiments. The physical theories that underlie this adjustment are assumed to be valid, such as quantum electrodynamics (QED). Testing QED, one of the most precise theories is the aim of many accurate experiments. The calculations and the corresponding experiments can be carried out either on a boundless system, such as the electron magnetic moment anomaly, or on a bound system, such as atomic hydrogen. The value of fundamental constants can be deduced from the comparison of theory and experiment. For example, using QED calculations, the value of the fine structure constant given by the CODATA is mainly inferred from the measurement of the electron magnetic moment anomaly carried out by Gabrielse's group. (Hanneke et al. 2008 Phys. Rev. Lett. 100, 120801) The value of the Rydberg constant is known from two-photon spectroscopy of hydrogen combined with accurate theoretical quantities. The Rydberg constant, determined by the comparison of theory and experiment using atomic hydrogen, is known with a relative uncertainty of 6.6×10(-12). It is one of the most accurate fundamental constants to date. A careful analysis shows that knowledge of the electrical size of the proton is nowadays a limitation in this comparison. The aim of muonic hydrogen spectroscopy was to obtain an accurate value of the proton charge radius. However, the value deduced from this experiment contradicts other less accurate determinations. This problem is known as the proton radius puzzle. This new determination of the proton radius may affect the value of the Rydberg constant . This constant is related to many fundamental constants; in particular, links the two possible ways proposed for the redefinition of the kilogram, the Avogadro constant N(A) and the Planck constant h. However, the current relative uncertainty on the experimental determinations of N(A) or h is three orders of magnitude larger than the 'possible' shift of the Rydberg constant, which may be shown by the new value of the size of the proton radius determined from muonic hydrogen. The proton radius puzzle will not interfere in the redefinition of the kilogram. After a short introduction to the properties of the proton, we will describe the muonic hydrogen experiment. There is intense theoretical activity as a result of our observation. A brief summary of possible theoretical explanations at the date of writing of the paper will be given. The contribution of the proton radius puzzle to the redefinition of SI-based units will then be examined.

The proton is the primary building block of the visible Universe, but many of its properties-such as its charge radius and its anomalous magnetic moment-are not well understood. The root-mean-square charge radius, r(p), has been determined with an accuracy of 2 per cent (at best) by electron-proton scattering experiments. The present most accurate value of r(p) (with an uncertainty of 1 per cent) is given by the CODATA compilation of physical constants. This value is based mainly on precision spectroscopy of atomic hydrogen and calculations of bound-state quantum electrodynamics (QED; refs 8, 9). The accuracy of r(p) as deduced from electron-proton scattering limits the testing of bound-state QED in atomic hydrogen as well as the determination of the Rydberg constant (currently the most accurately measured fundamental physical constant). An attractive means to improve the accuracy in the measurement of r(p) is provided by muonic hydrogen (a proton orbited by a negative muon); its much smaller Bohr radius compared to ordinary atomic hydrogen causes enhancement of effects related to the finite size of the proton. In particular, the Lamb shift (the energy difference between the 2S(1/2) and 2P(1/2) states) is affected by as much as 2 per cent. Here we use pulsed laser spectroscopy to measure a muonic Lamb shift of 49,881.88(76) GHz. On the basis of present calculations of fine and hyperfine splittings and QED terms, we find r(p) = 0.84184(67) fm, which differs by 5.0 standard deviations from the CODATA value of 0.8768(69) fm. Our result implies that either the Rydberg constant has to be shifted by -110 kHz/c (4.9 standard deviations), or the calculations of the QED effects in atomic hydrogen or muonic hydrogen atoms are insufficient.