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547 results on '"Nef, Holger M."'

4. First randomised controlled trial comparing the sirolimus-eluting bioadaptor with the zotarolimus-eluting drug-eluting stent in patients with de novo coronary artery lesions: 12-month clinical and imaging data from the multi-centre, international, BIODAPTOR-RCT

Author

Saito, Shigeru, Bennett, Johan, Nef, Holger M., Webster, Mark, Namiki, Atsuo, Takahashi, Akihiko, Kakuta, Tsunekazu, Yamazaki, Seiji, Shibata, Yoshisato, Scott, Douglas, Vrolix, Mathias, Menon, Madhav, Möllmann, Helge, Werner, Nikos, Neylon, Antoinette, Mehmedbegovic, Zlatko, Smits, Pieter C., Morice, Marie-Claude, and Verheye, Stefan

Published
2023
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6. Early Outcomes of 2 Mitral Valve Transcatheter Leaflet Approximation Devices: A Propensity Score–Matched Multicenter Comparison

Author

Mauri, Victor, Sugiura, Atsushi, Spieker, Max, Iliadis, Christos, Horn, Patrick, Öztürk, Can, Besler, Christian, Riebisch, Matthias, Al-Hammadi, Osamah, Ruf, Tobias, Gerçek, Muhammed, Grothusen, Christina, Mehr, Michael, Becher, Marc Ulrich, Mues, Christoph, Boeder, Niklas, Kreidel, Felix, Friedrichs, Kai, Westenfeld, Ralf, Braun, Daniel, Baldus, Stephan, Rassaf, Tienush, Thiele, Holger, Nickenig, Georg, Hausleiter, Jörg, Möllmann, Helge, Kelm, Malte, Rudolph, Volker, von Bardeleben, Ralph Stephan, Nef, Holger M., Luedike, Peter, Lurz, Philipp, and Pfister, Roman

Published
2022
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8. Manual der Arbeitsgruppe Interventionelle Kardiologie (AGIK) der Deutschen Gesellschaft für Kardiologie – Herz- und Kreislaufforschung e.V. (DGK): Teil 2: „Durchführung der perkutanen Koronarintervention“

Author

Nef, Holger M., Achenbach, Stephan, Birkemeyer, Ralf, Bufe, Alexander, Dörr, Oliver, Elsässer, Albrecht, Gaede, Luise, Gori, Tommaso, Hoffmeister, Hans M., Hofmann, Felix J., Katus, Hugo A., Liebetrau, Christoph, Massberg, Steffen, Pauschinger, Matthias, Schmitz, Thomas, Süselbeck, Tim, Voelker, Wolfram, Wiebe, Jens, Zahn, Ralf, Hamm, Christian, Zeiher, Andreas M., and Möllmann, Helge

Published
2021
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9. Coronary plaque and clinical characteristics of South Asian (Indian) patients with acute coronary syndromes: An optical coherence tomography study

Author

Nakajima, Akihiro, Subban, Vijaykumar, Russo, Michele, Bryniarski, Krzysztof L., Kurihara, Osamu, Araki, Makoto, Minami, Yoshiyasu, Soeda, Tsunenari, Yonetsu, Taishi, Crea, Filippo, Takano, Masamichi, Higuma, Takumi, Kakuta, Tsunekazu, Adriaenssens, Tom, Boeder, Niklas F., Nef, Holger M., Raffel, Owen C., McNulty, Iris, Lee, Hang, Nakamura, Sunao, Abdullakutty, Jabir, Mathew, Rony, Sankardas, Mullasari Ajit, and Jang, Ik-Kyung

Published
2021
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10. Manual der Arbeitsgruppe Interventionelle Kardiologie (AGIK) der Deutschen Gesellschaft für Kardiologie – Herz- und Kreislaufforschung e. V. (DGK): Teil 1: „Durchführung der diagnostischen Herzkatheteruntersuchung“

Author

Nef, Holger M., Achenbach, Stephan, Birkemeyer, Ralf, Bufe, Alexander, Dörr, Oliver, Elsässer, Albrecht, Gaede, Luise, Gori, Tommaso, Hoffmeister, Hans M., Hofmann, Felix J., Katus, Hugo A., Liebetrau, Christoph, Massberg, Steffen, Pauschinger, Matthias, Schmitz, Thomas, Süselbeck, Tim, Voelker, Wolfram, Wiebe, Jens, Zahn, Ralf, Hamm, Christian, Zeiher, Andreas M., and Möllmann, Helge

Published
2021
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11. Epicardial adipose tissue and muscle distribution affect outcomes in very old patients after transcatheter aortic valve replacement.

Author

Rohrbach, Susanne, Uluocak, Oezge, Junge, Marieke, Knapp, Fabienne, Schulz, Rainer, Böning, Andreas, Nef, Holger M, Krombach, Gabriele A, and Niemann, Bernd

Subjects
EPICARDIAL adipose tissue, HEART valve prosthesis implantation, GROWTH differentiation factors, BODY mass index, RECEIVER operating characteristic curves
Abstract

Aims To analyse the relevance of body composition and blood markers for long-term outcomes in very old patients after transcatheter aortic valve replacement (TAVR). Methods and results A total of 403 very old patients were characterized with regard to subcutaneous, visceral, and epicardial fat, psoas muscle area, plasma growth differentiation factor 15 (GDF-15), and leptin. Cohorts grouped by body mass index (BMI) were analysed for long-term outcomes. Patients underwent transapical and transfemoral TAVR (similar 30-day/1-year survival). Body mass index >35 kg/m2 showed increased 2- and 3-year mortality compared with BMI 25–34.9 kg/m2 but not compared with BMI <25 kg/m2. Fat areas correlated positively to BMI (epicardial: R 2 = 0.05, P < 0.01; visceral: R 2 = 0.20, P < 0.001; subcutaneous: R 2 = 0.13, P < 0.001). Increased epicardial or visceral but not subcutaneous fat area resulted in higher long-term mortality. Patients with high BMI (1781.3 mm2 ± 75.8, P < 0.05) and lean patients (1729.4 ± 52.8, P < 0.01) showed lower psoas muscle area compared with those with mildly elevated BMI (2055.2 ± 91.7). Reduced psoas muscle area and increased visceral fat and epicardial fat areas were independent predictors of long-term mortality. The levels of serum GDF-15 were the highest in BMI >40 kg/m2 (2793.5 pg/mL ± 123.2) vs. BMI <25 kg/m2 (2017.6 pg/mL ±130.8), BMI 25–30 kg/m2 (1881.8 pg/mL ±127.4), or BMI 30–35 kg/m2 (2054.2 pg/mL ±124.1, all P < 0.05). Increased GDF-15 level predicted mortality (2587 pg/mL, area under the receiver operating characteristic curve 0.94). Serum leptin level increased with BMI without predictive value for long-term mortality. Conclusion Morbidly visceral and epicardial fat accumulation, reduction in muscle area, and GDF-15 increase are strong predictors of adverse outcomes in very old patients post-TAVR. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Early Clinical Experience With the TRICENTO Bicaval Valved Stent for Treatment of Symptomatic Severe Tricuspid Regurgitation: A Multicenter Registry

Author

Wild, Mirjam G., Lubos, Edith, Cruz-Gonzalez, Ignacio, Amat-Santos, Ignacio, Ancona, Marco, Andreas, Martin, Boeder, Niklas F., Butter, Christian, Carrasco-Chinchilla, Fernando, Estevez-Loureiro, Rodrigo, Kempfert, Jörg, Köll, Benedikt, Montorfano, Matteo, Nef, Holger M., Toggweiler, Stefan, Unbehaun, Axel, Werner, Paul, Windecker, Stephan, and Praz, Fabien

Published
2022
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13. German Multicenter Experience With a New Leaflet-Based Transcatheter Mitral Valve Repair System for Mitral Regurgitation

Author

Mauri, Victor, Besler, Christian, Riebisch, Matthias, Al-Hammadi, Osamah, Ruf, Tobias, Gerçek, Muhammed, Horn, Patrick, Grothusen, Christina, Mehr, Michael, Becher, Marc Ulrich, Mues, Christoph, Boeder, Niklas, Kreidel, Felix, Friedrichs, Kai, Westenfeld, Ralf, Braun, Daniel, Öztürk, Can, Baldus, Stephan, Rassaf, Tienush, Thiele, Holger, Nickenig, Georg, Hausleiter, Jörg, Möllmann, Helge, Kelm, Malte, Rudolph, Volker, von Bardeleben, Ralph-Stephan, Nef, Holger M., Luedike, Peter, Lurz, Philipp, and Pfister, Roman

Published
2020
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19. Calcified Plaques in Patients With Acute Coronary Syndromes

Author

Sugiyama, Tomoyo, Yamamoto, Erika, Fracassi, Francesco, Lee, Hang, Yonetsu, Taishi, Kakuta, Tsunekazu, Soeda, Tsunenari, Saito, Yoshihiko, Yan, Bryan P., Kurihara, Osamu, Takano, Masamichi, Niccoli, Giampaolo, Crea, Filippo, Higuma, Takumi, Kimura, Shigeki, Minami, Yoshiyasu, Ako, Junya, Adriaenssens, Tom, Boeder, Niklas F., Nef, Holger M., Fujimoto, James G., Fuster, Valentin, Finn, Aloke V., Falk, Erling, and Jang, Ik-Kyung

Published
2019
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20. The role of Matrix Metalloproteinase-2 and Galectin-3 as predictive biomarkers for all-cause mortality in patients undergoing transfemoral transcatheter aortic valve implantation.

Author

Piayda, Kerstin, Heilemann, Julian Tim, Keranov, Stanislav, Schulz, Luisa, Arsalan, Mani, Liebetrau, Christoph, Kim, Won-Keun, Hofmann, Felix J., Bauer, Pascal, Voss, Sandra, Troidl, Christian, Sossalla, Samuel T., Hamm, Christian W., Nef, Holger M., and Dörr, Oliver

Subjects
HEART valve prosthesis implantation, GALECTINS, MORTALITY, DISEASE risk factors, AORTIC stenosis, ARTIFICIAL knees
Abstract

Currently available risk scores fail to accurately predict morbidity and mortality in patients with severe symptomatic aortic stenosis who undergo transcatheter aortic valve implantation (TAVI). In this context, biomarkers like matrix metalloproteinase-2 (MMP-2) and Galectin-3 (Gal-3) may provide additional prognostic information. Patients with severe aortic stenosis undergoing consecutive, elective, transfemoral TAVI were included. Baseline demographic data, functional status, echocardiographic findings, clinical outcomes and biomarker levels were collected and analysed. The study cohort consisted of 89 patients (age 80.4 ± 5.1 years, EuroScore II 7.1 ± 5.8%). During a median follow-up period of 526 d, 28 patients (31.4%) died. Among those who died, median baseline MMP-2 (alive: 221.6 [170.4; 263] pg/mL vs. deceased: 272.1 [225; 308.8] pg/mL, p < 0.001) and Gal-3 levels (alive: 19.1 [13.5; 24.6] pg/mL vs. deceased: 25 [17.6; 29.5] pg/mL, p = 0.006) were higher than in survivors. In ROC analysis, MMP-2 reached an acceptable level of discrimination to predict mortality (AUC 0.733, 95% CI [0.62; 0.83], p < 0.001), but the predictive value of Gal-3 was poor (AUC 0.677, 95% CI [0.56; 0.79], p = 0.002). Kaplan–Meier and Cox regression analyses showed that patients with MMP-2 and Gal-3 concentrations above the median at baseline had significantly impaired long-term survival (p = 0.004 and p = 0.02, respectively). In patients with severe aortic stenosis undergoing transfemoral TAVI, MMP-2 and to a lesser extent Gal-3, seem to have additive value in optimizing risk prediction and streamlining decision-making. [ABSTRACT FROM AUTHOR]

Published
2024
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21. One‐Year Outcomes According to Mitral Regurgitation Etiology Following Transcatheter Edge‐to‐Edge Repair With the PASCAL System: Results From a Multicenter Registry

Author

von Stein, Philipp, primary, Besler, Christian, additional, Riebisch, Matthias, additional, Al‐Hammadi, Osamah, additional, Ruf, Tobias, additional, Gerçek, Muhammed, additional, Grothusen, Christina, additional, Mehr, Michael, additional, Becher, Marc Ulrich, additional, Friedrichs, Kai, additional, Öztürk, Can, additional, Baldus, Stephan, additional, Guthoff, Henning, additional, Rassaf, Tienush, additional, Thiele, Holger, additional, Nickenig, Georg, additional, Hausleiter, Jörg, additional, Möllmann, Helge, additional, Horn, Patrick, additional, Kelm, Malte, additional, Rudolph, Volker, additional, von Bardeleben, Ralph‐Stephan, additional, Nef, Holger M., additional, Luedike, Peter, additional, Lurz, Philipp, additional, Pfister, Roman, additional, and Mauri, Victor, additional

Published
2023
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24. Cardiovascular Emergency Surgery After Acute Renal Failure: A Case Report

Author

Boeder Niklas F., Dörr Oliver, Rutsatz Wiebke, Bauer Timm, and Nef Holger M.

Subjects
aortic dissection, emergency room, trauma room, communication, syncope, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

We describe the case of a 68-year-old patient who was admitted to the trauma unit with anisocoria after pre-hospital resuscitation upon loss of consciousness. An intracranial bleeding was ruled out. The patient was admitted to the cardiology ward with the initial diagnosis of a syncope due to myocarditis, as myocardial necrosis markers were slightly elevated. The suspicion of an acute aortic dissection (AAD) was raised when the patient developed kidney failure and a progressive aortic regurgitation. He underwent emergency surgery for an acute type A AAD. Renal function recovered completely and, fortunately, the patient was discharged 10 days later.

Published
2018
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