Search

The ‘relational turn’ has been widely embraced in Human Geography and related fields over the last couple of decades as an alternative to the hubris of modern and colonial reasoning. Yet, increasingly, concerns over the extent that contemporary conceptualisations are overly ‘generative’, ‘productivist’ and ‘affirmational’ has come to the fore. There is significant interest in the possibilities for more negative understandings, highlighting failure, attrition, voiding, exhaustion, impotentiality, incompleteness and attributes of ‘non‐relation’. We draw out how, to date, most of these approaches have developed a hermeneutic approach, seeking to bring the negative and the non‐relational into the world as forces of disruption and refusal, holding open other possibilities of knowing and being in the world and enabling alternative political imaginaries. This paper seeks to outline an alternative mode of critique, one that places both relational and negative approaches under the scrutiny of an ‘abyssal’ approach. Here, after Fanon, the world violently forged into the global colour line is bifurcated via the construction of the modern subject, capable of reading itself as a subject in the world and through Human Geography as a field of study. In this always already antiblack world, the goal of ‘Abyssal Geography’ is not to continue worlding the modern subject in new ways, but to analyse and critique the mechanisms and shifts in critical thought through which Human Geography continues to salvage and to redeem the purchase of the modern subject and the world. [ABSTRACT FROM AUTHOR]

Background: Serpiginous-like choroiditis (SLC) denotes ocular tuberculosis (TB), in the presence of positive tuberculin skin test (TST) or interferon gamma release assay (IGRA). Methods: Retrospective review of SLC patients from a TB-endemic country, with negative TST and IGRA tests, but responsive to anti-TB therapy. Results: Fifteen patients (13 bilateral) with active SLC were included. Eleven (73.3%) patients had received corticosteroids ± immunosuppressive therapy prior to presentation. Chest radiographic abnormalities were found in four (26.7%) patients. We treated all patients with a combination of anti-TB therapy (ATT) and corticosteroids. Paradoxical worsening was noted in nine (60%) patients, complete resolution of lesions in 12 (80%), persistent inflammation (post-ATT) in one, while two were yet to complete ATT. None had recurrence after complete resolution of lesions (median follow-up of 71 weeks [range 15–676 weeks]). Conclusions: TB-SLC may present with negative TST and IGRA tests but may still have clinical appearance, and treatment response, like test-positive disease. [ABSTRACT FROM AUTHOR]

Septic arthritis of the hip is a serious infection in children. However, blood and joint fluid cultures are often negative, which makes the diagnosis and treatment challenging. We analyzed the clinical features of children with septic arthritis of the hip with negative bacterial cultures and identified the risk factors for poor outcomes. The clinical data of children with septic arthritis of the hip with negative bacterial cultures who were treated at our hospital from January 2010 to December 2020 were retrospectively analyzed. The clinical characteristics and outcomes of the culture-negative cohort were compared with those of children with positive bacterial cultures treated during the same period. Culture-negative patients were divided into a group with good outcomes and a group with poor outcomes. The differences between the two groups were compared. Thirty-nine children with culture-negative septic arthritis of the hip were compared with 37 children with culture-positive sepsis. Compared with the culture-positive group, the culture-negative group had a significantly younger mean age and a significantly lower mean serum C-reactive protein concentration. Logistic regression analysis of culture-negative patients with good versus poor outcomes revealed that the independent risk factors for poor outcomes were an increased serum C-reactive protein concentration and prolonged time from onset to surgery. The cut-off values for predicting a poor outcome in the culture-negative group were a time from onset to surgery of greater than 21 days and a C-reactive protein concentration of greater than 23 mg/L. Culture-negative septic arthritis of the hip has similar clinical features to culture-positive septic arthritis of the hip and can result in sequelae of varying severity. Therefore, active anti-infective and hip drainage therapy should be performed when children present with clinical symptoms, inflammatory marker concentrations, and imaging findings that are clinically diagnostic for septic arthritis of the hip. Level II, retrospective study. [ABSTRACT FROM AUTHOR]

To determine how vulnerable various pea genotypes are to leafminer infestation, a field experiment was conducted. On the basis of the presence of mines on five randomly selected leaflets from the upper, middle and lower parts of the plant, observations of larvae were made throughout the growing season. The total phenols were determined using the method described by Bray and Thorpe (1954, Analysis of phenolic compounds of interest in metabolism. Methods Biochem Anal. 52:1–27) and absorbance at 650 nm was measured using a spectrophotometer. There was a negative correlation between leafminer infestation and total phenol content. The UHF Pea-12 genotype, characterised by the lowest total phenol concentration (20.87 mg/100 g), exhibited the highest level of leaflet infestation (17.33%). Although UHF Pea-1 genotype had the lowest mean leaflet infestation (6.58%), it also had the highest phenol concentration (41.91 mg per 100 g). In context with this, the present study highlights the significance of host-plant resistance (HPR) in pest management. [ABSTRACT FROM AUTHOR]

This study investigates biological interactions and social structures within psychological frameworks in different manifestations of dominance and suppression classifying into conscious, subconscious, and unconscious mind states by looking at empirical research and theoretical models. This paper then details their mechanisms and impacts on individual and group behavior by looking into intentional, semi-intentional, and non-intentional mechanisms, respectively. This study explores the role that dominance and suppression play in forming social and biological hierarchies as well as individual psychologies, in addition to outlining the traits and outcomes of each type. The results are intended to advance knowledge of power relations in various contexts and offer new perspectives on the advantages and disadvantages of dominance and suppression. [ABSTRACT FROM AUTHOR]

Background: Fear of negative evaluation, defined as a sense of dread associated with being unfavorably evaluated in a social situation, is the primary factor underlying student anxiety in college science courses and is disproportionately experienced by students who are underserved in science. Yet, it is unknown why fear of negative evaluation disproportionately affects these students and what can be done to reduce student fear of negative evaluation. Academic social comparison describes how students perceive themselves compared to their peers with regard to desirability as a groupmate, the extent they fit in among others in their major, and academic talent. We hypothesize that academic social comparison mediates the relationship between student identities and fear of negative evaluation, where individuals with underserved identities in science may perceive themselves as "less than" their peers, contributing to their fear of negative evaluation. We surveyed 909 undergraduate science majors across 15 research-intensive institutions in the United States (U.S.) to assess: (1) To what extent do student identities predict fear of negative evaluation among science undergraduates? and (2) For identities that significantly predict fear of negative evaluation, to what extent does academic social comparison mediate the relationship? We used regression, single-mediator models, and multi-mediator models to address our research questions. Results: Women/non-binary and LGBTQ + science majors reported disproportionately high fear of negative evaluation compared to men and non-LGBTQ + science majors. Women/non-binary and LGBTQ + students also expressed lower academic social comparison relative to their respective counterparts, meaning they perceive themselves as less than their peers with regard to their desirability as a groupmate, the extent to which they fit in among others in their major, and their academic talent. Academic social comparison partially mediated the relationship between fear of negative evaluation and both gender and LGBTQ + status. Major fit, defined as the extent to which students perceive they fit in among others in their major, was found to be the primary mediating subconstruct of academic social comparison for both gender and LGBTQ + identities. Conclusions: Women/non-binary and LGBTQ + science majors perceive themselves as less than their peers to a greater extent than men and non-LGBTQ + science majors, contributing to their higher fear of negative evaluation in college science course. Major fit, defined as the extent to which students feel they fit in with others in their major, is the subconstruct of academic social comparison that had the strongest influence on fear of negative evaluation in our sample. Academic social comparison is a promising target for future efforts aimed at decreasing fear of negative evaluation in active learning college science courses. [ABSTRACT FROM AUTHOR]

Objective: The study aimed to evaluate negative and positive emotional responses to acute psychological stress in individuals with early life stress (ELS). Methods: One hundred sixty-one participants from the Birmingham community in Alabama completed the study and were stratified into 2 groups based on measurements of ELS using the Childhood Trauma Questionnaire and a confirmatory clinical interview. Acute psychological stress, that is, the Trier Social Stress Test (TSST), was administered, and emotional responses were measured using the Visual Analogue Scale. Comparisons utilized chi-square for categorical variables and t-test for continuous variables. Analysis of covariance (ANCOVA) was applied to compare the 2 groups after controlling for confounding variables. Stepwise multiple linear regression analysis was used to investigate predictive power of variables for emotional responses to the TSST. Results: Participants with ELS experienced less pleasantness at the baseline (P = .02), and 1 minute (P = .04), but not 90 minutes time points compared to the non-ELS group. Participants in the ELS group also reported higher anxiety at baseline (P = .003), and 90 minutes (P = .04) post-TSST. Data analysis showed the effect of time on emotional responses during the TSST. Different emotional responses, including pleasantness, anxiety, fatigue, and vigor, were able to be predicted by ELS severity. Conclusion: Our data demonstrates that individuals with ELS presented different positive and negative emotional responses when exposed to acute psychological stress. Our findings may be useful for clinicians who work with individuals with ELS. Our findings also highlight the importance of recognizing emotional responses and of building up resilience in response to acute stress. [ABSTRACT FROM AUTHOR]

We reported a large-scale Internet-based experiment to investigate the impact of emotion information on Chinese word segmentation, in which participants completed an overlapping ambiguous string (OAS) segmentation task and the Chinese version of Beck Depression Inventory-II in a counterbalanced order. OAS is a three-character string (ABC) in which the middle character can form a distinct word with both the character on its left side (word AB) and the character on its right side (word BC). Participants were presented with isolated OASs and were asked to report the word they identified first. Emotional OAS was constructed by a combination of a neutral word and an emotional word, with the neutral and emotional words sharing character B. We orthogonally manipulated the valence of the emotional words (positive vs. negative) and their position in the OAS (left-side vs. right-side). The results showed that compared with neutral words, both positive and negative words were more likely to be segmented, and this segmentation outcome was not affected by readers with different depression tendencies. These findings suggest that emotion information can influence word segmentation, and that both positive and negative words take precedence over neutral words in the word segmentation process. This study provides a new perspective and evidence to understand the impact of emotion information on word processing. [ABSTRACT FROM AUTHOR]

In this article the communicative-pragmatic types of verbalizers related to the concept of "mood" in English and Uzbek are revealed and how cultural and linguistic differences influence the expression of mood in both languages, utilizing examples from literature, everyday communication, and idiomatic expressions are given. The study aims to enhance understanding of mood as a linguistic phenomenon and its pragmatic implications in crosscultural communication. [ABSTRACT FROM AUTHOR]

AbstractObjective: We generated items to assess COVID-19 changes among Hispanic college students and examined the concurrent and predictive effects of these changes vis-à-vis mental health. Participants: The sample consisted of 559 Hispanic first-year (69% women; age range 18–22; 88.1% U.S.-born; 84% Mexican/Mexican American) attending a public university in Texas. Methods: Students participated in a three-wave longitudinal online survey assessing stressors, COVID-19 changes, anxious and depressive symptoms, hope, and self-esteem. Results: Students experienced negative changes across six life domains as a result of the pandemic-related lockdowns: education; health; relationships; finances; social issues; death/loss. They also reported positive changes during the lockdowns. Negative changes were positively correlated with higher, and positive changes with lower, acculturative and perceived stress. Negative COVID-19 changes predicted lower mental health. Conclusions: Hispanic students experienced both negative and positive COVID-19 changes, which were related to their mental health. Results can guide research and decision-making during future pandemics. [ABSTRACT FROM AUTHOR]

This research raises the case of the impact of Mobile Legends on communication science students of the class of 2017. Such games can reduce their academic productivity, leading to a reduction in time that would otherwise be spent on studies and other academic activities. Mobile Legends can also cause addiction, disrupt sleep, reduce physical activity, and trigger social isolation. This study uses a qualitative method by utilizing the theory of interpersonal relationship needs, which highlights individual relationships in achieving certain satisfaction under existing conditions. Students who experience an increase in the level of addiction to the game tend to experience disturbances in maintaining a balance between real life and virtual life. The impact includes decreased productivity in daily activities and difficulties in communicating directly with others. Based on the results of the research that has been conducted, it can be concluded that the Mobile Legends online game has a significant impact on intrapersonal communication of Communication Science students of Mulawarman University class of 2017. These impacts include increased multitasking skills, improved strategic thinking skills, and improved emotional management skills. [ABSTRACT FROM AUTHOR]

The Quantum Noise Stream Cipher (QNSC) is offering very high security in physical layer of optical fiber communication network to meet the today's main requirement of secure networks. However, the problem of timing and carrier frequency offset synchronization was higher for Coherent optical orthogonal Frequency Division Multiplexing (CO-OFDM) systems using QNSC for network security. For higher-order modulation systems, the algorithms used to overcome this problem are offering very low accuracy. In addition to this, the chances of attack by an illegal receiver are more due to no encryption used for the preamble creation. Existing algorithms used to create a new preamble is: CNI ((conjugate, negative, and image) with Pseudo-Noise sequence) and CNC ((conjugate and negative) with Chu sequence). In this paper, ConvNN (Convolutional Neural Network) and CapNN (Capsule Neural Network) based joint synchronization of timing and frequency for CO-OFDM system is proposed. From the experiments, performed at 10Gbps, it has been illustrated that the proposed networks are giving more robust results. In addition to these proposed networks are offering better and secure performance for both timing and frequency offset synchronization by using less training data. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Anbar University for Law & Political Sciences is the property of Republic of Iraq Ministry of Higher Education & Scientific Research (MOHESR) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Lockdown, isolation, quarantine, and social distancing are proven to be the only effective measures to prevent and tackle COVID-19 to date. Unfortunately, these measures have caused physical, economical, and mental health problems. Despite a growing interest in the field, scarce narrative studies have delved into adolescents' psychological experiences related to global emergencies caused by infectious diseases. Considering the lack of knowledge in literature and the need to investigate an unexplored topic, a qualitative study was performed to explore adolescents' feelings and thoughts using their narratives. The study was carried out with 150 adolescent students who are continuing their studies in Marawi City. Findings show that adolescents were more forthcoming about their negative experiences than about positive ones. Looking at word occurrence in the two texts (positive and negative experience), many commonalities emerged. Overall, 9 words out of 20 are shared in the vocabulary of the two collected narratives. Looking at the modeling emergent themes analysis, the T-Lab software revealed four themes for each text. [ABSTRACT FROM AUTHOR]

In this paper it will be analyzed grammatical and dialectal aspect of structural sentences of Albanian language used in six Kosovo Police Communication Centers. This paper includes: types of sentences used in Communication Centers separately; enhancing sentences, declarative sentences, declarative-exclamatory sentences and declarative-imperative; imperative sentences; - affirmative and negative sentences. All sections of this paper are illustrated with tables and charts, including number of used sentences and percentage of usage, to present the current situation of use of structural types of sentences in the Kosovo Police Communication Centers. Based on the results from six Communication Centers, which we have analyzed and treated separately, we have come to conclusions of the analysis of the grammatical and dialectal aspects. In Kosovo Police Communication Centers, within the category of declarative sentences, we find positive and negative sentences, which are formed by positive and negative particles, as: Poziiv (Positive), Negativ (Negative), Negativ niher (Negative for now), Po (Yes), Jo (No), veç çka po vrehet n’pamje t’jashtme (only what can be seen from outside), etc. In six Kosovo Police Communication Centers, the affirmative sentences are mainly formed through affirmative particles, as: pozitiv (positive), pranim (copy), po, po – po (yes, yeas – yes), u ba (done), ani faleminderit (OK thank you), n’rregull (alright), e kjart osht n’rregull (it’s clear alright), u kry (done), etc.

Breast cancer is the most common malignant tumor in women, posing a serious threat to women's health. HER2 has been identified as a key oncogene and prognostic factor in breast cancer. Recent studies have reported inconsistencies in ER, PR, and/or HER2 expression between primary breast tumors and metastatic lesions. Rarely is it reported that all three biomarkers experience conversion. In this report, we present the case of a female patient with relapsed and metastatic breast cancer, whose histology transformed from initially triplenegative to Luminal-B type (HER2 positive) (i.e., ER, PR, and HER2 positive). She underwent systematic chemotherapy, targeted therapy, and cranial radiotherapy, which was followed by maintenance treatment with targeted and endocrine therapy. Currently, she has been in nearly complete remission (nCR) for more than 12 months. For recurrent and metastatic breast cancer, it is necessary to perform the second biopsy for metastases, which would contribute to precision treatment and prognosis improvement. [ABSTRACT FROM AUTHOR]

We systematically reviewed extant studies evaluating the efficacy and tolerability of xanomeline and xanomeline-trospium (KarXT) for treatment of adults with schizophrenia. In accordance with PRISMA guidelines, articles were systematically searched for in databases and clinical trial registries. A total of 4 preclinical trials and 3 randomized controlled trials (RCTs) were included in this review. A 4-week RCT observed a difference of 24.0 points (SD 21.0) in the Positive and Negative Syndrome Scale (PANSS) total score between xanomeline and placebo groups (p = 0.039). A 5-week RCT observed PANSS total score changes from baseline to week 5, including −17.4 and −5.9 points in KarXT and placebo groups, respectively (LSMD −11.6 points; 95% CI −16.1 to −7.1; p < 0.001; d = 0.75). Another 5-week RCT observed PANSS total score changes from baseline to week 5, including −21.2 (SE 1.7) and −11.6 (SE 1.6) points in KarXT and placebo groups, respectively (LSMD −9.6; 95% CI −13.9 to −5.2; p < 0.0001; d = 0.61). Side effects include constipation, nausea, vomiting, dyspepsia, and dry mouth. KarXT offers an innovative non-D2 blocking approach, representing a promising treatment avenue for schizophrenia. [ABSTRACT FROM AUTHOR]

The tower structure and geometrical arrangement of transmission line conductors in the power system depend on various technical, economic, and geographical factors and the age of construction of the lines. Thus, the arrangement of lines may not be transposed or follow the standards of the electricity industry. The untransposed conductors cause asymmetric couplings in the transmission lines, directly leading to destructive effect on the function of distance protection and accurate determination of the fault location. Fault location in untransposed transmission lines is presented as a novel research piece by investigating the circuit equations of positive-negative-zero sequences and using synchronous voltage measurements taken from the near and far terminals of the transmission line together with measuring the current of one terminal. In this algorithm, the effect of mutual interphase impedance and admittance due to the untransposed structure of the line is fully taken into account. Fault location equations are designed based on the complete equivalent circuit of the untransposed transmission line using the modeling of all effective parameters. As the presented design adopts the current measurements of one terminal, the destructive effect of the current measurement systems is dropped. The Simulink model of the suggested design has been implemented in Digsilent Power Factory software and the algorithm has been programmed in MATLAB software. The performance of the proposed algorithm has been tested and evaluated for a two-terminal network in normal and critical fault conditions, as well as for a 39-bus untransposed New England network. According to the obtained results, the average estimation error of all scenarios is approximately equal to 0.07%. The results presented in the simulation and sensitivity analysis section confirm the accurate and correct performance of the algorithm.

Recently published qualitative meta-analysis on negative experiences from clients’ perspective (Vybíral et al., 2024) was extended for purpose of the theoretical review. Further studies published in the last two years were included as well as studies based on complaints collected by ethical bodies. Relevant dissertations and diploma theses were not excluded as well. This review offers a large overview focused on kinds of negative experiences, on possible classifications, on frequencies of mentioned negative events and effects in several studies, asking also for causes. The clients’ negative experiences include boundary crossing, including boundaries of intimacy, or sexuality, experiences with inappropriate therapists’ behavior and failed termination of treatment. The frequency of negative experiences might be higher compared with traditional estimations between 5 and 13 percent. Today, the problem has been accepted and described in wide range of studies. Causes of negative effects are identified on both the therapist’s and client’s side. [ABSTRACT FROM AUTHOR]

Simple Summary: Histone deacetylase inhibitors (HDACIs) represent a relatively new drug class with potent regulatory effects on the epigenetics in cancer, ranging from apoptosis induction and cancer cell death to cell cycle arrest. In spite of the fact that HDACIs have, so far, received approval for the treatment of mainly hematologic malignancies, there are numerous preclinical, as well as, clinical trials in the setting of (triple negative) breast cancer with very promising results. In this study, we aimed at assessing the clinical importance of HDAC-2 in triple negative breast cancer. A total of 138 breast cancer specimens were examined immunohistochemically. This current study demonstrated that increased HDAC-2 expression correlates with significant clinicopathological parameters of triple negative breast cancer patients, such as survival, recurrence, and disease stage. Background/Aim: Triple negative breast cancer belongs to the most aggressive breast cancer forms. Histone deacetylases (HDACs) constitute a class of enzymes that exhibit a significant role in breast cancer genesis and progression. In this study, we aimed at assessing the clinical importance of HDAC-2 in triple negative breast cancer. Materials and Methods: A total of 138 breast cancer specimens were examined on an immunohistochemical basis. A statistical analysis was performed in order to examine the association between HDAC-2 and the survival and clinicopathological features of the patients. Results: Increased HDAC-2 expression was observed in every fourth case of triple negative breast cancer with positive HDAC-2 staining, whereas only 12 out of 98 non-triple negative breast cancer samples showed high HDAC-2 expression. HDAC-2 overexpression correlated with prolonged overall survival (OS) and disease-free survival (DFS) in triple negative breast cancer. Conclusions: High HDAC-2 levels in triple negative breast cancer seem to positively influence patient survival, disease stage and recurrence. [ABSTRACT FROM AUTHOR]

Copyright of International Journal on Humanities & Social Sciences is the property of International Journal on Humanities & Social Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Information Library Magazine 'INFOLIB' is the property of National Library of Uzbekistan named after Alisher Navoi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Test-negative-design COVID-19 vaccine effectiveness (VE) studies use symptomatic SARS-CoV-2-positive individuals as cases and symptomatic SARS-CoV-2-negative individuals as controls to evaluate COVID-19 VE. To evaluate the potential bias introduced by the correlation of COVID-19 and influenza vaccination behaviors, we assessed changes in estimates of VE of bivalent vaccines against COVID-19-associated hospitalizations and emergency department/urgent care (ED/UC) encounters when considering influenza vaccination status or including or excluding influenza-positive controls using data from the multi-state VISION vaccine effectiveness network. Analyses included encounters during October 2022 – February 2023, a period of SARS-CoV-2 and influenza cocirculation. When considering influenza vaccination status or including or excluding influenza-positive controls, COVID-19 VE estimates were robust, with most VE estimates against COVID-19-associated hospitalization and ED/UC encounters changing less than 5 percentage points. Higher proportions of influenza-positive patients among controls, influenza vaccination coverage, or VE could impact these findings; the potential bias should continue to be assessed. [ABSTRACT FROM AUTHOR]

As a continuity to the study by M. Kafini [24], we consider a logarithmic nonlinear wave condition with delay term. We obtain a blow-up result of solutions under suitable conditions. [ABSTRACT FROM AUTHOR]

This study focused on issues relating to communication patterns and parent-child relationships among households resident in University of Nigeria Nsukka (UNN) senior staff quarters. Specifically, the study determined ways family communication patterns influence parent/adolescent-child relationship among residents of UNN senior staff quarters (SSQs), digital communication channels used by families to enhance parent/adolescent-child relationship among residents of UNN SSQs, challenges that militate against parent/adolescent-child relationship and communication among residents of UNN SSQs and solutions to challenges militating against parent/adolescent-child relationship and communication among residents of UNN SSQs. The study adopted a survey design. Population for study comprised of residents of senior staff quarters in University of Nigeria Nsukka. Data were collected using questionnaire. Data were analyzed using mean and standard deviation. Findings include 11 possible ways communication patterns (open, close, aggressive and passive) influence parent/adolescent-child relationship. For instance, open communication pattern can engender “trust” (X̄ = 2.97), “enjoyment” (X̄ = 3.37), instruction/teaching/learning (X̄ = 2.92), and so on. Other findings include seven groups of digital channels used in parent/adolescent-child communication. These include mobile application (APPs) (X̄ = 3.31), video calls (X̄ = 3.12), social media (X̄ = 3.03), online learning (X̄ = 2.72), and others. Further findings are eight challenges militating against parent/adolescent-child relationship and communication, such as, busy schedules of parents (X̄ = 3.22), differences in communication styles among family members (X̄ = 3.11). More findings are seven measures for ameliorating the challenges, including, establishing regular family communication time (X̄ = 3.03), respect for other opinions (X̄ = 3.11), use open communication patterns and be honest (X̄ = 2.92). and others. Based on the findings four recommendations were made. [ABSTRACT FROM AUTHOR]

The paper investigates various definitions of the concept of opinion as opposed to factual or evidence-based statements and proposes a taxonomy of opinions expressed in English as identified in selected social media. A discussion situates opinions in the realm of pragmatics and reaches to philosophy of language and cognitive science. The research methodology combines a thorough linguistic analysis of opinions, proposing their multifaceted taxonomy with the automatically generated lexical embeddings of positive and negative lexicon acquired from the analysed opinionated texts. As proposed, the definition of the concept of opinion is best apprehended when looked upon in terms of an opinion event, with a number of necessary conditions on the one hand, and those that are characteristic of an explicit opinion prototype on the other. Lists of opinion discourse markers show their preferential uses either in positive or negative opinionated texts; however, no sets of necessary and/or sufficient opinion markers properties have been acquired from the analysed texts. The conclusions indicate a polysemous understanding of naturally occurring social media opinionated texts and a definitional flexibility of the boundaries around lexical positive and negative types of opinion markers. [ABSTRACT FROM AUTHOR]

Sarcasm can be defined as the use of words that mean the opposite of what the speaker actually says, especially to insult the recipient, to show irritation or to amuse the others. Sarcastic remarks are funny and constructive when they are mutually understood within a genuine relationship. Sarcasm has the potential to catalyze creativity for those who produce and receive it. A positive message delivered in a friendly tone - „You did a great job” and a negative message delivered in a patronizing or deprecating tone - “Your answers are far beyond all expectations” - are congruent.

The contact of lasers with biomaterials like tissues, blood, and skin is a central field of research. Invitro irradiation of human blood with laser beams has been studied for decades, to understand the biostimulatory effects on the different blood cells. Laser tissue associations are determined by employing spectroscopic and cutting-edge microscopic technicality. In this study, blood was extracted under standard laboratory settings from healthy human subjects. The samples were exposed to He - Ne laser (wavelength ʎ= 650nm, power p= 100mW) and green laser (wavelength ʎ= 530nm, power p= 500mW).Complete blood count (CBC) and FTIR spectra for non-irradiated samples were compared to CBC and FTIR spectra of irradiated samples.During exposure to green laser light MCH and PCT were not affected while under He-Ne laser exposure all CBC parameters were affected. FTIR spectrum of normal blood laser irradiation indicated that O-H, C=O, C-O, NH, N=O and C-H.As the duration of exposure to He-Ne laser irradiation on whole blood is decreased for 10, 20, and 30 minutes, the absorption for all groups, except NH and CO absent peaks for 10 and 20 minutes, yet it is present in 30 minutes.When blood is exposed to green laser, all of the functional groups OH,C=O,CH and N=O are present, however for control 2 only peaks of CO after irradiation for 30 minutes are absent. The findings prove that green laser light therapy has a lesser effect on the blood component than He-Ne lasers.

Politeness strategy is a strategy in the use of language related to the use of good and polite verbal communication, which can make communication work cooperatively. In terms of communicating, politeness strategies are very important to avoid conflicts in communication which means avoiding face-threatening acts (FTA) of the hearer. In researching politeness strategy, the film is a work of art that can be analyzed because it has characters and utterances that can be analyzed and are closely related to real life. Thus, a film entitled "Gifted" was chosen because this film is related to the education of gifted children, the parenting of gifted children, and is built on mental health issues in the world of learning. This study aims to analyze the politeness strategy of the main character in this film. This research used a qualitative descriptive approach and audio-visual data collection approach. The result of the analysis shows there are 60 politeness strategies data found from 512 utterances from the main characters. 37 data of positive politeness strategy categorized into three subtypes: Claim common ground (12 data), Convey that speaker and hearer are cooperators (24 data), and fulfill hearer’s want (1 data). 23 data of negative politeness strategy that categorized into: be direct (9 data), do not presume or assume (3 data), do not coerce hearer (3 data), and communicate speaker’s want to not impinge (23 data).

Rationale: Long-acting antipsychotics such as haloperidol decanoate are becoming more commonly used. Long-acting depot formulations have several advantages, but secondary negative effects of prolonged delivery, including motivational dysfunctions, could have debilitating effects. Assessing the behavioral changes that emerge during chronic antipsychotic administration in rats could provide insight regarding the development of motivational dysfunctions and drug tolerance. Objectives: Acute administration of dopamine D2 antagonists such as haloperidol induce motivational deficits in rats, as marked by a shift towards a low-effort bias during effort-based choice tasks. In the present studies, programmable subcutaneous infusion pumps provided continuous and controlled drug delivery of haloperidol. Animals were assessed using a fixed ratio (FR) 5 lever pressing schedule and the FR5/chow feeding test of effort-based choice. The adenosine A2A antagonist istradefylline was studied for its ability to reverse the effects of chronic haloperidol. Results: Continuous chronic infusions of haloperidol produced significant reductions in FR5 performance and a shift from lever pressing to chow intake in rats tested on FR5/chow feeding choice, with no evidence of tolerance over the 4-week infusion period. Behavior returned to baseline during the vehicle-infusion washout period. Istradefylline significantly reversed the effects of haloperidol, increasing lever pressing and decreasing chow intake in haloperidol-treated rats. Conclusions: These studies provide an important behavioral characterization of the effects of chronically infused haloperidol, and demonstrate that A2A antagonism reverses the effects of chronic haloperidol. This research could contribute to the understanding and treatment of motivational dysfunctions seen in schizophrenia, Parkinson's disease, and other disorders involving dopamine. [ABSTRACT FROM AUTHOR]

Compared to our understanding of positive prediction error signals occurring due to unexpected reward outcomes, less is known about the neural circuitry in humans that drives negative prediction errors during omission of expected rewards. While classical learning theories such as Rescorla-Wagner or temporal difference learning suggest that both types of prediction errors result from a simple subtraction, there has been recent evidence suggesting that different brain regions provide input to dopamine neurons which contributes to specific components of this prediction error computation. Here, we focus on the brain regions responding to negative prediction error signals, which has been well-established in animal studies to involve a distinct pathway through the lateral habenula. We examine the activity of this pathway in humans, using a conditioned inhibition paradigm with high-resolution functional MRI. First, participants learned to associate a sensory stimulus with reward delivery. Then, reward delivery was omitted whenever this stimulus was presented simultaneously with a different sensory stimulus, the conditioned inhibitor (CI). Both reward presentation and the reward-predictive cue activated midbrain dopamine regions, insula and orbitofrontal cortex. While we found significant activity at an uncorrected threshold for the CI in the habenula, consistent with our predictions, it did not survive correction for multiple comparisons and awaits further replication. Additionally, the pallidum and putamen regions of the basal ganglia showed modulations of activity for the inhibitor that did not survive the corrected threshold.

Abstract Trust has been shown to be a key component of a successful business-to-business (B2B) relationship. However, recent studies have pointed to the potential adverse effects on different aspects of the relationship, with a lack of knowledge on how calculative trust and relational trust interact and their ramifications for long-term relationships, particularly in the agri-food context. Fifteen semi-structured interviews were conducted among different members of the rainbow trout and lamb supply chains in Canada. The data indicated that both types of trust can coexist in a long-term relationship, and while calculative trust can give rise to adverse effects such as complacency and payment delays, relational trust can help alleviate some of those impacts. [ABSTRACT FROM AUTHOR]

We present a textual analysis that explains how Elon Musk's sentiments in his Twitter content correlates with price and volatility in the Bitcoin market using the dynamic conditional correlation-generalized autoregressive conditional heteroscedasticity model, allowing less sensitive to window size than traditional models. After examining 10,850 tweets containing 157,378 words posted from December 2017 to May 2021 and rigorously controlling other determinants, we found that the tone of the world's wealthiest person can drive the Bitcoin market, having a Granger causal relation with returns. In addition, Musk is likely to use positive words in his tweets, and reversal effects exist in the relationship between Bitcoin prices and the optimism presented by Tesla's CEO. However, we did not find evidence to support linkage between Musk's sentiments and Bitcoin volatility. Our results are also robust when using a different cryptocurrency, i.e., Ether this paper extends the existing literature about the mechanisms of social media content generated by influential accounts on the Bitcoin market. [ABSTRACT FROM AUTHOR]

Under study are the closure properties for various classes of separable congruences (in particular, of equivalences) of numbered algebras on the natural numbers under the upper and lower bounds in the lattice of congruences. We show that the class of all positive congruences forms a sublattice whereas the classes of negative, computably separable, and separable congruences form a lower but not always an upper subsemilattice. It is shown that uniformly computably separable congruences can fail to form lower and upper semilattices. We give a characterization of semienumerable sets in terms of uniformly computably separable equivalences. [ABSTRACT FROM AUTHOR]

Problem statement and purpose: Cardiorespiratory fitness (CRF) is recognized as a modifiable risk factor that can help reduce the risk of non-communicable diseases, and as such, it serves as a crucial reference for vital signs. Moreover, it has been found to have a negative association with clinical symptoms. Nevertheless, the specific impact of each variable on the clinical symptoms of schizophrenia (SP) remains unclear. Therefore, the objective of this study was to examine the predictive significance of CRF and body composition concerning clinical symptom factors in the population with SP. Approach: Body composition, specifically body mass index (BMI), and CRF, measured as peak oxygen uptake from the cardiopulmonary exercise test, were evaluated in all participants (n = 122, 41.6 ± 10.3 years old, 16.7% women). The psychopathology of the participants was assessed using the Brief Negative Symptom Scale and the Positive and Negative Syndrome Scale. Correlations, including Spearman's Rho and Pearson's r, were conducted to examine the relationships between sociodemographic factors, symptoms, and BMI. Stepwise Multiple Regression analyses were then employed to identify the variables that can predict CRF. Results: The correlations revealed a negative association between negative symptoms and peak oxygen uptake (mL·kg−1·min−1) (B = −0.252; P < 0.001). The regression analysis showed that lower peak oxygen uptake (L·min−1) (P < 0.001) and higher BMI (P = 0.019) were predictors of negative symptoms, explaining 22.8% of the variance (R² = 22.8%; F = 8.067; P < 0.001). Additionally, lower peak oxygen uptake (mL·kg−1·min−1) (P = 0.016) predicted general symptoms (R² = 12.3%; F = 5.135; P = 0.002), and lower peak oxygen uptake (mL·kg−1·min−1) (P = 0.001) predicted total symptoms (R² = 17.8%; F = 7.928; P < 0.001). Conclusions: Given the significant associations observed between CRF and BMI with negative symptoms, and CRF with general and total symptoms, it becomes evident that enhancing physical health through exercise and adopting a healthy diet may serve as crucial adjunctive treatments for managing SP disorder. [ABSTRACT FROM AUTHOR]

Triple-negative breast cancer (TNBC) has been known as havoc among females globally. It is a heterogeneous group of cancer encompassing many breast cancers basically distinct by the lack of estrogen receptor, progesterone receptor, and overextension of the human epidermal growth factor receptor-2 gene. It can be caused by various factors, namely unbalanced diet, beverage consumption, smoking, hormonal imbalance, medication, genetic factor, and decreased levels of physical activity. It represents one of the most aggressive types of breast cancer, and researchers revealed that the chemical components of cardamom, namely limonene, cymene, pinene, linalool, borneol, cardamonin, indole-3-carbinol, and diindolylmethane, primarily target the programmed cell death lignin-1 gene of cancer which is more abundant in cancer cells than in healthy cells. There is no standard chemotherapy session for eradicating TNBC because targeted receptor absents in cancer cells as present in common breast cancer. Cardamonin has been identified as an effective component that targets most of the signaling pathways against TNBC. Metallic chelates of cardamonin with copper ion help to improve lipophilicity and bioavailability in cancer cells. The literature included in this review was assessed from the international databases, namely PubMed, Elsevier, Scopus, Google Scholar, Bentham, and Research Gate journals published between 2010 and 2023. Utilizing keywords for literature searching are breast cancer, triple negative breast cancer, cardamom, bioavailability, and cardamonin. A safe and efficient targeted therapy for this cancer has been difficult to develop due to its rapid proliferation and indefinite signaling pathway. Literature investigation enlightened that phytoconstituent reported in the cardamom reporting anticancer potential action against TNBC. Data concluded from this review can prove beneficial to the communal population in the treatment of TNBC and improve the health indicator in the future.

Background: Serum interleukin 6 (IL-6) levels have been studied in the diagnostic evaluation of patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) disease (COVID-19). Methods: We studied the utility of treatment with tocilizumab in COVID-19 patients (n=19) with a negative nasopharyngeal swab real time reverse transcriptase polymerase chain reaction (RT-PCR) test for SARS-CoV-2 who had suggestive computed tomography (CT) findings, namely, COVID-19 Reporting and Data System (CO-RADS) 4,5. Results: Receiver operator characteristic (ROC) curve analysis showed that serum IL 6 at a cut-off of >56.9 pg/L was a predictor of mortality in nasopharyngeal swab RT-PCR negative patients with suggestive CT findings. Tocilizumab had no significant effect on the mortality. Conclusions: In nasopharyngeal swab RT-PCR negative patients with suggestive chest CT findings, elevated serum IL-6 levels > 56.9 pg/L predicted mortality. However, treatment with tocilizumab had no effect on mortality.

The Prostate Imaging Reporting and Data System (PI-RADS) has good ability to identify the nature of lesions on prostate magnetic resonance imaging (MRI). However, some lesions are still reported as PI-RADS 4 and 5 but are biopsy-proven benign. Herein, we aimed to summarize the reasons for the negative prostate biopsy of patients who were assessed as PI-RADS 4 and 5 by biparameter MRI. We retrospectively sorted out the prostate MRI, treatment, and follow-up results of patients who underwent a biparameter MRI examination of the prostate in The First Affiliated Hospital of Nanjing Medical University (Nanjing, China) from August 2019 to June 2021 with PI-RADS 4 and 5 but a negative biopsy. We focused on reviewing the MRI characteristics. A total of 467 patients underwent transperineal prostate biopsy. Among them, biopsy pathology of 93 cases were negative. After follow-up, 90 patients were ruled out of prostate cancer. Among the 90 cases, 40 were considered to be overestimated PI-RADS after review. A total of 22 cases were transition zone (TZ) lesions with regular appearance and clear boundaries, and 3 cases were symmetrical lesions. Among 15 cases, the TZ nodules penetrated the peripheral zone (PZ) and were mistaken for the origin of PZ. A total of 17 cases of lesions were difficult to distinguish from prostate cancer. Among them, 5 cases were granulomatous inflammation (1 case of prostate tuberculosis). A total of 33 cases were ambiguous lesions, whose performance was between PI-RADS 3 and 4. In summary, the reasons for “false-positive MRI diagnosis” included PI-RADS overestimation, ambiguous images giving higher PI-RADS, diseases that were really difficult to distinguish, and missed lesion in the initial biopsy; and the first two accounted for the most.

Abstract Background Fractional Flow Reserve (FFR) is a widely applied invasive physiological assessment, endorsed by major guidelines to aid in the decision to perform or defer revascularisation. While a threshold of > 0.8 has been applied universally, clinical outcomes may be affected by numerous factors, including the presence of diabetes. This meta-analysis aims to investigate the outcomes of diabetic versus non-diabetic patients in whom revascularisation was deferred based on negative FFR. Methods We performed a meta-analysis investigating the outcomes of diabetic and non-diabetic patients in whom revascularisation was deferred based on negative FFR. A search was performed on MEDLINE, PubMed and EMBASE, and peer-reviewed studies that reported MACE for diabetic and non-diabetic patients with deferred revascularisation based on FFR > 0.8 were included. The primary end point was MACE. Results The meta-analysis included 7 studies in which 4275 patients had revascularisation deferred based on FFR > 0.8 (1250 diabetic). Follow up occurred over a mean of 3.2 years. Diabetes was associated with a higher odds of MACE (OR = 1.66, 95% CI 1.35–2.04, p = 0.8, the presence of diabetes portends an increased long-term risk of MACE compared to non-diabetic patients. Trail registration URL: https://www.crd.york.ac.uk/PROSPERO/ ; Unique identifier: CRD42022367312.

Abstract Background According to the ActivityStat hypothesis more physical activity (PA) in one timespan is compensated by increased sedentary time (ST) in the following timespan and vice versa to maintain an overall stable PA level. Until now, existing literature revealed inconsistent results regarding compensatory behaviour across children and adolescents. Thus, the aim of the present study is (1) to investigate whether ST in the morning is compensated by active behaviour in the afternoon and (2) whether ST during the week is compensated by active behaviour during the weekend in (pre)adolescent girls. Additionally, we aimed to differentiate between positive and negative compensatory behaviour and examine whether it is moderated by socioeconomic status (SES), age or weight status. Methods The participants were 370 sixth grade school girls (mean age 11.6 years) from Munich that participated in the CReActivity study, a school based intervention study aiming to identify the mechanisms of behavioural changes in PA among girls. ST and PA were measured over seven consecutive days using accelerometery. Descriptive determination of compensatory behaviour, as well as Bayesian multivariate multilevel analysis were conducted with data clustered on the individual (ID), class and school level. Results Descriptive analysis revealed rather constant compensatory behaviour of about 60% for after-school days and weekends over all observation points. However, regarding all girls, compensation was predominantly negative. Differentiated analysis indicated that all girls with low ST levels in the morning or on weekdays, compensated for this behaviour with lower PA levels in the afternoon or on weekends. Multilevel covariate analysis indicated great variability between the participants. Furthermore, differences in compensatory behaviour can also be seen on class and school levels. Interestingly, PA compensatory behaviour is not associated with age, weight status or SES. Conclusion Our findings could neither confirm nor reject the ActivityStat Hypothesis. Overall, due to the great variability across the girls, it seems that compensation depends on individual factors. In the future, to prevent negative compensation, school-based interventions that have the potential to provide opportunities to be physically active, should not neglect (pre)adolescents’ leisure time behaviour. Trial Registration DRKS00015723 (date of registration: 2018/10/22 retrospectively registered).