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Patients with diabetes are particularly susceptible to COVID-19 infection, which can result in severe respiratory illness. This study conducted a comparative assessment of the impact of antiviral therapy using molnupiravir and favipiravir in COVID-19 patients with underlying diabetes. A cohort of one hundred individuals infected with SARS-CoV-2, diagnosed with diabetes, and consecutively admitted, was included in the present study. These patients were treated with antivirals according to local guidelines: Group F (51 cases) was treated with favipiravir - 10 days and Group M (49 cases) was treated with molnupiravir - 5 days. In Group F, the average hospitalization was higher than in Group M (11.29±2.27 vs. 7.14±3.16, p<0.001). The risk score for severe evolution was less statistically significant at the end point of treatment in group M (156.29±61.32; 160.59±59.41, p<0.001). Administration of molnupiravir led to a decrease in the number of deaths among patients with COVID-19 compared to those treated with favipiravir [2 (4.08%) vs. 9 (17.65%), p=0.034]. Molnupiravir demonstrated superiority over favipiravir in treating SARS-CoV-2 infection in diabetic patients, and controlling or diagnosing diabetes is crucial to prevent the critical progression of COVID-19 patients. Further research is needed to confirm its potential in the management of infected individuals with SARS-CoV-2. [ABSTRACT FROM AUTHOR]

Significant environmental and social issues confront the textile and apparel industries, including resource depletion and excessive textile waste. Implementing circular economy principles is essential for the sustainability of this industry. The present paper is a bibliometric analysis study type designed to identify collaborative networks, prolific countries, journals, and influential articles pertaining to the implementation of the circular economy in the textile and apparel industries that may serve as a starting point for an in-depth understanding of the subject, facilitating the knowledge of essential bibliometric parameters for pre-publication phases. The data were extracted from the Web of Science and analyzed using both the Web of Science web interface and the VOSviewer software version 1.6.19. The bibliometric data were divided into two distinct periods to analyze the evolution of this subject over time: from 1975 to 2010 and from 2011 to 2023. In the first period, the most productive country was the United States, with 527 publications, accounting for 10.81% of the scientific output during that time. In the second period, China emerged as the most productive country, with 2478 published documents, constituting 18.44% of the total production in this period. During the first period, Istanbul Technical University was the most active institution, with 91 publications (1.87% of the total production), while in the second period the Indian Institute of Technology System was the most productive, with 265 documents (1.95%). These key findings demonstrate the textile industry's commitment to sustainable and environmentally friendly practices. They also highlight the industry's adoption of advanced technologies and its exploration of new research areas; but there is still room for improvement, which is why continuous research implemented through future research areas is essential. [ABSTRACT FROM AUTHOR]

The primary purpose of this paper was to find new possible acetylcholinesterase inhibitors by utilizing molecular docking to assess the binding affinity of 30 distinct ligands to the AChE protein with the PDB ID: 6f25. The ligands were identified using SwissSimilarty and starting from the chemical structure of donepezil. The Discovery Studio package was used to evaluate ligand-protein interactions, while AutoDock Vina was employed for molecular docking. The reference ligand had an affinity of -7.8 Kcal/mol for the protein. Out of the 30 ligands, ZINC000032101422 had the highest affinity towards the protein (-10.4 Kcal/mol), followed by ZINC000049037726 with an affinity of -10.1 Kcal/mol and ZINC000034964947 with an affinity of -9.9. These findings suggest that these chemicals have the potential to be effective acetylcholinesterase inhibitors. In-silico studies provide a foundation for identifying potential compounds, but it is essential to validate these findings through further studies. [ABSTRACT FROM AUTHOR]

Alzheimer's disease (AD), once considered a rare disease, is now the most common form of dementia in the elderly population. Current drugs (cholinesterase inhibitors and glutamate antagonists) are safe but of limited benefit to most patients, offering symptomatic relief without successful cure of the disease. Since the last several decades, there has been a great need for the development of a treatment that might cure the underlying causes of AD and thereby slow its progression in vulnerable individuals. That is why phase I, II, and III studies that act on several fronts, such as cognitive improvement, symptom reduction, and enhancing the basic biology of AD, are imperative to stop the disease. This review discusses current treatment strategies, summarizing the clinical features and pharmacological properties, along with molecular docking analyses of the existing medications. [ABSTRACT FROM AUTHOR]