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27 results on '"Neis, Vivian B."'

21. Single administration of agmatine reverses the depressive-like behavior induced by corticosterone in mice: Comparison with ketamine and fluoxetine

Author

Neis, Vivian B., primary, Bettio, Luis B., additional, Moretti, Morgana, additional, Rosa, Priscila B., additional, Olescowicz, Gislaine, additional, Fraga, Daiane B., additional, Gonçalves, Filipe M., additional, Freitas, Andiara E., additional, Heinrich, Isabella A., additional, Lopes, Mark W., additional, Leal, Rodrigo B., additional, and Rodrigues, Ana Lúcia S., additional

Published
2018
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23. Evidence for the involvement of opioid system in the antidepressant-like effect of ascorbic acid.

Author

Moretti, Morgana, Ribeiro, Camille M., Neis, Vivian B., Bettio, Luis Eduardo B., Rosa, Priscila B., and Rodrigues, Ana Lúcia S.

Abstract

Considering the involvement of the opioid system in major depressive disorder (MDD), mainly concerning refractory MDD, and the evidence that ascorbic acid may exert a beneficial effect for the treatment of this disorder, this study investigated the involvement of the opioid system in the antidepressant-like effect of ascorbic acid in the tail suspension test (TST). Treatment of Swiss mice with the non-selective opioid receptor antagonist naloxone (1 mg/kg, i.p.) prevented the reduced immobility time caused by ascorbic acid (1 mg/kg, p.o.) in the TST. Additionally, administration of the selective μ1-opioid receptor antagonist, naloxonazine (10 mg/kg, i.p.), also abolished the antidepressant-like action of the same dose of ascorbic acid in the TST. We also investigated the possible relationship between the opioid system and NMDA receptors in the mechanism of action of ascorbic acid or ketamine (0.1 mg/kg, i.p.) in the TST. Treatment of mice with naloxone (1 mg/kg, i.p.) blocked the synergistic antidepressant-like effect of ascorbic acid (0.1 mg/kg. p.o.) and MK-801 (0.001 mg/kg, p.o., a non-competitive NMDA receptor antagonist) in the TST. Combined administration of ketamine and MK-801 induced a synergistic antidepressant-like action, and naloxone partially abolished this effect. Our results indicate that the antidepressant-like effect of ascorbic acid in the TST appears to be dependent on the activation of the opioid system, especially μ1-opioid receptors, which might be an indirect consequence of NMDA receptor inhibition elicited by ascorbic acid administration. [ABSTRACT FROM AUTHOR]

Published
2018
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24. Antidepressant-like action of the bark ethanolic extract from Tabebuia avellanedae in the olfactory bulbectomized mice

Author

Freitas, Andiara E., primary, Machado, Daniele G., additional, Budni, Josiane, additional, Neis, Vivian B., additional, Balen, Grasiela O., additional, Lopes, Mark W., additional, de Souza, Luiz F., additional, Veronezi, Patricia O., additional, Heller, Melina, additional, Micke, Gustavo A., additional, Pizzolatti, Moacir G., additional, Dafre, Alcir L., additional, Leal, Rodrigo B., additional, and Rodrigues, Ana Lúcia S., additional

Published
2013
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25. Rosmarinus officinalis L. hydroalcoholic extract, similar to fluoxetine, reverses depressive-like behavior without altering learning deficit in olfactory bulbectomized mice

Author

Machado, Daniele G., primary, Cunha, Mauricio P., additional, Neis, Vivian B., additional, Balen, Grasiela O., additional, Colla, André R., additional, Grando, Jaine, additional, Brocardo, Patricia S., additional, Bettio, Luis E.B., additional, Dalmarco, Juliana B., additional, Rial, Daniel, additional, Prediger, Rui D., additional, Pizzolatti, Moacir G., additional, and Rodrigues, Ana Lúcia S., additional

Published
2012
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26. Antidepressant-like effects of ascorbic acid and ketamine involve modulation of GABAAand GABABreceptors

Author

Rosa, Priscila B., Neis, Vivian B., Ribeiro, Camille M., Moretti, Morgana, and Rodrigues, Ana Lúcia S.

Abstract

•Ascorbic acid and ketamine have antidepressant effects in the tail suspension test.•Ascorbic acid and muscimol co-administration has antidepressant effect in mice.•Ketamine and muscimol co-administration elicits an anti-immobility effect in mice.•Baclofen prevents antidepressant-like effect of ascorbic acid and ketamine in mice.

Published
2016
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27. Role of agmatine in neurodegenerative diseases and epilepsy.

Author

Moretti M, Matheus FC, de Oliveira PA, Neis VB, Ben J, Walz R, Rodrigues AL, and Prediger RD

Subjects
Agmatine administration & dosage, Agmatine therapeutic use, Antidepressive Agents administration & dosage, Antidepressive Agents therapeutic use, Humans, Learning drug effects, Memory drug effects, Neuroprotective Agents administration & dosage, Neuroprotective Agents therapeutic use, Agmatine pharmacology, Antidepressive Agents pharmacology, Brain Injuries drug therapy, Central Nervous System metabolism, Epilepsy drug therapy, Neurodegenerative Diseases drug therapy, Neuroprotective Agents pharmacology
Abstract

Agmatine, a cationic polyamine synthesized after decarboxylation of L-arginine by the enzyme arginine decarboxylase, is an endogenous neuromodulator that emerges as a potential agent to manage diverse central nervous system (CNS) disorders. Consistent with its neuromodulatory and neuroprotective properties, there is increasing number of preclinical studies demonstrating the beneficial effects of exogenous agmatine administration on depression, anxiety, hypoxic ischemia, nociception, morphine tolerance, memory, Parkinson`s disease, Alzheimer`s disease, traumatic brain injury related alterations/disorders and epilepsy. The aim of this review is to summarize the knowledge about the effects of agmatine in CNS and point out its potential as new pharmacological treatment for diverse neurological and neurodegenerative diseases. Moreover, some molecular mechanisms underlying the neuroprotective effects of agmatine will be discussed.

Published
2014
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