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The Golden (British Columbia, Canada) meteorite fall occurred on October 4, 2021 at 0534 UT with the first recovered fragment (1.3 kg) landing on an occupied bed. The associated fireball was recorded by numerous cameras permitting reconstruction of its trajectory and orbit. The fireball entered the atmosphere at a 54° angle from the horizontal at a speed of 18 km s−1. The fireball reached a peak brightness of −14, having first become luminous at a height of >84 km and ending at 18 km altitude. Analysis of the infrasonic record of the bolide produced an estimated mass of (Formula presented.) kg while modeling of the fireball light curve suggests an initial mass near 70 kg. The fireball experienced a major flare near 31 km altitude where more than half its mass was lost in the form of dust and gram-sized fragments under a dynamic pressure of 3.3 MPa. The strength and fragmentation behavior of the fireball were similar to those reported for other meteorite-producing fireballs (Borovička et al., 2020). Seven days after the fireball occurred, an additional 0.9 kg fragment was recovered during the second day of dedicated searching guided by initial trajectory and dark flight calculations. Additional searching in the fall and spring of 2021–2022 located no additional fragments. The meteorite is an unbrecciated, low-shock (S2) ordinary chondrite of intermediate composition, typed as an L/LL5 with a grain density of ~3530 k gm−3, an average bulk density of 3150 kg m−3 and calculated porosity of ~10%. From noble gas measurements, the cosmic ray exposure age is 25 ± 4 Ma while gas retention ages are all >2 Ga. Short-lived radionuclides and noble gas measurements of the pre-atmospheric size overlap with estimates from infrasound and light curve modeling producing a preferred pre-atmospheric mass of 70–200 kg. The orbit of Golden has a high inclination (23.5°) and is consistent with delivery from the inner main belt. The highest probability (60%) of an origin is from the Hungari

Objective: The aim was to assess the use of telehealthcare in rheumatology before coronavirus disease 2019 (COVID-19), to which future comparisons of newer interventions adapted during the crisis can be made. Methods: We performed a registered systematic literature search using MEDLINE, EMBASE, CENTRAL and PubMed databases. All full-length articles comparing telehealthcare delivery models with standard care (face-to-face consultation) in the management of patients with rheumatic conditions were assessed for inclusion. Results: A total of 4809 studies were identified; 108 studies were suitable for review by full text, and 13 studies were appropriate to be included in this review. Five studies (38%) included patients with RA, four studies (31%) included patients with mixed disease cohorts, two studies (15%) included patients with OA, one study (8%) included patients with JIA, and one study (8%) included patients with FM. Six studies (46%) used telephone consultation, three studies (23%) used mixed method communication, three studies (23%) used videoconferencing, and one study (8%) used website-delivered telecommunication as their method of telehealthcare delivery. Overall, seven studies (54%) identified the telehealthcare intervention to be an effective method of consultation, and six studies (46%) identified the telehealthcare intervention as non-inferior when compared with standard care. Conclusion: Current evidence for telehealthcare in rheumatology is lacking, and the evidence for effectiveness is limited by methodological bias and clinical heterogeneity of telehealthcare interventions, preventing definitive inferences. Scrutinous assessment of the current telehealthcare interventions used during COVID-19 is required to accommodate recommendations and guideline reviews directed from international working groups.

Background Cardiovascular disease is the leading cause of death in patients with chronic kidney disease. Studies investigating the disproportionate burden of cardiovascular disease have occurred predominantly in the peripheral vasculature, often used noninvasive imaging modalities, and infrequently recruited patients receiving dialysis. This study sought to evaluate invasive coronary dynamic vascular function in patients with end-stage renal failure (ESRF). Patients and methods Patients referred for invasive coronary angiography prior to renal transplantation were invited to participate. Control patients were recruited in parallel. Baseline characteristics were obtained. Coronary diameter (via quantitative coronary angiography) and coronary blood flow (via Doppler Flowire) were measured; macrovascular endothelial-dependent and independent effects were evaluated in response to intracoronary acetylcholine infusion (10-7 and 10-6 mol/l) and intracoronary glyceryl trinitrate, respectively. Microvascular function was evaluated by response to adenosine and expressed as coronary flow velocity reserve. Mean values were compared. Results Thirty patients were evaluated: 15 patients with ESRF (mean age 52.1 +/- 9, male 73%) and 15 control patients (mean age 53.3 +/- 13, male 60%). Comorbidity profile, aside from ESRF, was well matched. Baseline coronary blood flow was similar between groups (101.6 +/- 10.3 vs. 103.4 +/- 9.1 ml/min, P = 0.71), as was endothelial-dependent response to acetylcholine (159.1 +/- 16.9 vs. 171.1 +/- 16.8 ml/min, P = 0.41). Endothelial-independent response to glyceryl trinitrate was no different between groups (14.3 +/- 3.1 vs. 13.1 +/- 2.3%, P = 0.73. A significantly reduced coronary flow velocity reserve was observed in the ESRF cohort compared to controls (2.34 +/- 0.4 vs. 3.05 +/- 0.3, P = 0.003). Conclusion Patients with ESRF had preserved endothelial-dependent function however compared to controls, demonstrated significantly attenuated microvasc

Background and aims: Echocardiographic studies have shown improvements in cardiac indices associated with renal sympathetic denervation (RDN), however, the benefits on myocardial perfusion have never been assessed. This trial was designed to study the effects of RDN on myocardial perfusion using cardiac magnetic resonance (CMR) imaging. Method(s): A total of 14 patients with resistant hypertension were recruited for RDN and myocardial perfusion, alongside other CMR indices, was assessed at baseline and at 6 months. Result(s): RDN showed significant reduction of mean office blood pressures from 181/100 +/- 19/16 mmHg to 147/85 +/- 19/17 mmHg, 6 months after the procedure (p < 0.0001). This was combined with significant improvement in regional aortic distensibility (p < 0.02) and associated with trends of improved myocardial perfusion reserve index (baseline = 2.2 +/- 1; 6 months = 2.9 +/- 1 units) (p = 0.08). Left ventricular end systolic volume index decreased from baseline to 6 months post procedure, 27 +/- 13 ml/m2 vs. 22 +/- 10 ml/m2 (p = 0.03), but there was no significant change in left ventricular end diastolic volume index (p = 0.09). There was significant improvement in mean left ventricular ejection fraction from 68 +/- 10% to 72 + 9%, 6 months post procedure (p = 0.04). T1 mapping failed to detect fibrosis in these patients at baseline and therefore no change was noted, however, extracellular volume percent improved from 46 +/- 4% at baseline to 41 +/- 8% at 6 months (p = 0.002). Conclusion(s): This study demonstrates that renal sympathetic denervation increased myocardial perfusion by 32% as assessed by CMR, and, this was associated with improvements in cardiac volumes and function. Larger well controlled and randomized studies are required to assess the clinical significance of these findings.Copyright © 2018